SIGMAR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.78479595
2L-phenylalanine catabolic process (GO:0006559)6.78479595
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.69676041
4L-phenylalanine metabolic process (GO:0006558)6.69676041
5aromatic amino acid family catabolic process (GO:0009074)6.05199759
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.00241949
7alpha-linolenic acid metabolic process (GO:0036109)5.65881321
8sulfur amino acid catabolic process (GO:0000098)5.55255848
9glyoxylate metabolic process (GO:0046487)5.54396095
10kynurenine metabolic process (GO:0070189)5.48000515
11negative regulation of fibrinolysis (GO:0051918)5.47970598
12indole-containing compound catabolic process (GO:0042436)5.43119743
13indolalkylamine catabolic process (GO:0046218)5.43119743
14tryptophan catabolic process (GO:0006569)5.43119743
15bile acid biosynthetic process (GO:0006699)5.40492503
16cysteine metabolic process (GO:0006534)5.19946721
17tryptophan metabolic process (GO:0006568)5.13493567
18urea cycle (GO:0000050)5.12769468
19urea metabolic process (GO:0019627)5.12769468
20protein carboxylation (GO:0018214)5.12610146
21peptidyl-glutamic acid carboxylation (GO:0017187)5.12610146
22high-density lipoprotein particle remodeling (GO:0034375)5.10540446
23regulation of fibrinolysis (GO:0051917)5.02469659
24complement activation, alternative pathway (GO:0006957)4.99537676
25glycine metabolic process (GO:0006544)4.98028425
26serine family amino acid catabolic process (GO:0009071)4.97374947
27regulation of protein activation cascade (GO:2000257)4.95819049
28DNA unwinding involved in DNA replication (GO:0006268)4.92563053
29nitrogen cycle metabolic process (GO:0071941)4.70790471
30regulation of complement activation (GO:0030449)4.65404671
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.62743213
32bile acid metabolic process (GO:0008206)4.56266645
33proline biosynthetic process (GO:0006561)4.55728657
34lysine catabolic process (GO:0006554)4.53725786
35lysine metabolic process (GO:0006553)4.53725786
36serine family amino acid biosynthetic process (GO:0009070)4.52563717
37DNA strand elongation involved in DNA replication (GO:0006271)4.50825442
38homocysteine metabolic process (GO:0050667)4.47949143
39regulation of cholesterol esterification (GO:0010872)4.44009484
40aromatic amino acid family metabolic process (GO:0009072)4.43012360
41serine family amino acid metabolic process (GO:0009069)4.42078483
42reverse cholesterol transport (GO:0043691)4.40658043
43plasma lipoprotein particle remodeling (GO:0034369)4.38989503
44protein-lipid complex remodeling (GO:0034368)4.38989503
45macromolecular complex remodeling (GO:0034367)4.38989503
46regulation of triglyceride catabolic process (GO:0010896)4.37186820
47DNA strand elongation (GO:0022616)4.36381853
48amino-acid betaine metabolic process (GO:0006577)4.36257421
49alpha-amino acid catabolic process (GO:1901606)4.33464973
50triglyceride homeostasis (GO:0070328)4.32159223
51acylglycerol homeostasis (GO:0055090)4.32159223
52plasma lipoprotein particle clearance (GO:0034381)4.31503456
53negative regulation of sterol transport (GO:0032372)4.28758052
54negative regulation of cholesterol transport (GO:0032375)4.28758052
55imidazole-containing compound metabolic process (GO:0052803)4.26982862
56protein maturation by protein folding (GO:0022417)4.26219138
57tyrosine metabolic process (GO:0006570)4.25626842
58coenzyme catabolic process (GO:0009109)4.22349857
59protein retention in ER lumen (GO:0006621)4.16372118
60establishment of integrated proviral latency (GO:0075713)4.16299948
61maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.14075211
62telomere maintenance via semi-conservative replication (GO:0032201)4.08465222
63phospholipid efflux (GO:0033700)4.07979109
64ethanol oxidation (GO:0006069)4.05283119
65aldehyde catabolic process (GO:0046185)4.03475370
66cellular amino acid catabolic process (GO:0009063)4.03202924
67cellular modified amino acid catabolic process (GO:0042219)4.01964238
68COPI coating of Golgi vesicle (GO:0048205)3.95893080
69Golgi transport vesicle coating (GO:0048200)3.95893080
70bile acid and bile salt transport (GO:0015721)3.95114447
71regulation of mitochondrial translation (GO:0070129)3.91886003
72nucleobase-containing small molecule interconversion (GO:0015949)3.85053887
73L-serine metabolic process (GO:0006563)3.79463741
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77431327
75cellular ketone body metabolic process (GO:0046950)3.76918617
76folic acid metabolic process (GO:0046655)3.75766897
77benzene-containing compound metabolic process (GO:0042537)3.71997487
78indolalkylamine metabolic process (GO:0006586)3.71844886
79glutamate metabolic process (GO:0006536)3.71533983
80amine catabolic process (GO:0009310)3.71506924
81cellular biogenic amine catabolic process (GO:0042402)3.71506924
82plasma lipoprotein particle assembly (GO:0034377)3.71045378
83cellular glucuronidation (GO:0052695)3.70001246
84fibrinolysis (GO:0042730)3.69907251
85proline metabolic process (GO:0006560)3.68418280
86cholesterol efflux (GO:0033344)3.67514058
87cofactor catabolic process (GO:0051187)3.67270498
88regulation of translational fidelity (GO:0006450)3.66430701
89dicarboxylic acid biosynthetic process (GO:0043650)3.60997185
90regulation of cholesterol homeostasis (GO:2000188)3.60733276
91positive regulation of triglyceride lipase activity (GO:0061365)3.58738421
92positive regulation of lipoprotein lipase activity (GO:0051006)3.58738421
93low-density lipoprotein particle remodeling (GO:0034374)3.57569369
94acetyl-CoA metabolic process (GO:0006084)3.57477831
95one-carbon metabolic process (GO:0006730)3.55505958
96arginine metabolic process (GO:0006525)3.54458357
97DNA replication initiation (GO:0006270)3.53369729
98organic acid catabolic process (GO:0016054)3.51084817
99carboxylic acid catabolic process (GO:0046395)3.51084817
100establishment of viral latency (GO:0019043)3.48601246
101complement activation, classical pathway (GO:0006958)3.48486448
102mitotic chromosome condensation (GO:0007076)3.47784330
103response to nitrosative stress (GO:0051409)3.47575745
104complement activation (GO:0006956)3.47475001
1052-oxoglutarate metabolic process (GO:0006103)3.47152820
106blood coagulation, intrinsic pathway (GO:0007597)3.43772812
107cholesterol homeostasis (GO:0042632)3.42801645
108positive regulation of lipid catabolic process (GO:0050996)3.39442875
109protein activation cascade (GO:0072376)3.38327963
110very-low-density lipoprotein particle assembly (GO:0034379)3.38082267
111sterol homeostasis (GO:0055092)3.37040741
112heterochromatin organization (GO:0070828)3.36580681
113protein-lipid complex assembly (GO:0065005)3.35998672
114cytolysis (GO:0019835)3.35740887
115plasma lipoprotein particle organization (GO:0071827)3.33774309
116lipoprotein metabolic process (GO:0042157)3.33284287
117pyridine nucleotide biosynthetic process (GO:0019363)3.32950138
118nicotinamide nucleotide biosynthetic process (GO:0019359)3.32950138
119heme transport (GO:0015886)3.32429860
120epoxygenase P450 pathway (GO:0019373)3.32190364
121aspartate family amino acid catabolic process (GO:0009068)3.31918444
122nuclear envelope reassembly (GO:0031468)3.30737129
123mitotic nuclear envelope reassembly (GO:0007084)3.30737129
124pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.28111150
125peptidyl-arginine omega-N-methylation (GO:0035247)3.25162880
126pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.22298381
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.20783537
128formation of translation preinitiation complex (GO:0001731)3.19969027
129mitotic sister chromatid segregation (GO:0000070)3.18529337
130ribosomal small subunit biogenesis (GO:0042274)3.18401978
131telomere maintenance via recombination (GO:0000722)3.14849561
132pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.06546330
133regulation of mammary gland epithelial cell proliferation (GO:0033599)3.03688965
134ribosome biogenesis (GO:0042254)2.99287049
135mitotic recombination (GO:0006312)2.97262425
136ribonucleoprotein complex biogenesis (GO:0022613)2.94974360
137folic acid-containing compound biosynthetic process (GO:0009396)2.92527284
138guanosine-containing compound biosynthetic process (GO:1901070)2.91170165
139UTP biosynthetic process (GO:0006228)2.89708287
140ribosomal large subunit biogenesis (GO:0042273)2.89339173
141pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.86660510
142regulation of translational termination (GO:0006449)2.84557211
143nucleobase biosynthetic process (GO:0046112)2.81896294
144tRNA aminoacylation for protein translation (GO:0006418)2.81888875
145folic acid-containing compound metabolic process (GO:0006760)2.81724033
146purine nucleobase biosynthetic process (GO:0009113)2.81493014
147ribosome assembly (GO:0042255)2.80642723
148protein complex localization (GO:0031503)2.80142868
149proteasome assembly (GO:0043248)2.79147098
150CTP metabolic process (GO:0046036)2.79009883
151CTP biosynthetic process (GO:0006241)2.79009883
152rRNA transcription (GO:0009303)2.78336555
153sister chromatid segregation (GO:0000819)2.76598963
154nuclear pore complex assembly (GO:0051292)2.76218543
155mitotic metaphase plate congression (GO:0007080)2.75439914
156histone arginine methylation (GO:0034969)2.74799647
157pentose-phosphate shunt (GO:0006098)2.74182674
158nucleotide-excision repair, DNA gap filling (GO:0006297)2.73690595
159amino acid activation (GO:0043038)2.73370497
160tRNA aminoacylation (GO:0043039)2.73370497
161maturation of SSU-rRNA (GO:0030490)2.70403542
162tetrahydrofolate metabolic process (GO:0046653)2.70385277
163base-excision repair (GO:0006284)2.68551440
164glutamine family amino acid biosynthetic process (GO:0009084)2.67632175
165negative regulation of mRNA processing (GO:0050686)2.67600766
166protein localization to chromosome, centromeric region (GO:0071459)2.65304338
167regulation of mitotic spindle organization (GO:0060236)2.65041902
168IMP biosynthetic process (GO:0006188)2.64738949
169UTP metabolic process (GO:0046051)2.63923106
170anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62229462
171negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.62125413
172cellular protein complex localization (GO:0034629)2.61929518
173DNA replication checkpoint (GO:0000076)2.60817621
174mitotic nuclear envelope disassembly (GO:0007077)2.60458336
175regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.60319833
176GDP-mannose metabolic process (GO:0019673)2.58801191
177glucose catabolic process (GO:0006007)2.58423731
178telomere maintenance via telomere lengthening (GO:0010833)2.57699798
179deoxyribonucleotide biosynthetic process (GO:0009263)2.57395510
180NADPH regeneration (GO:0006740)2.56377108
181pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.54048500
182pentose metabolic process (GO:0019321)2.52878423
183negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.52607712
184negative regulation of ligase activity (GO:0051352)2.52607712
185alpha-amino acid biosynthetic process (GO:1901607)2.50678185
186pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.50315298
187peptidyl-arginine N-methylation (GO:0035246)2.49739155
188peptidyl-arginine methylation (GO:0018216)2.49739155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.62642400
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.61760235
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.89134222
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.14954906
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.10233884
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.82589387
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.38764352
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.86661663
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.57401876
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.23962178
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.86588604
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56871233
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.51268053
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47899885
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42009590
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.32091078
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18607521
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09281486
19E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95320055
20CLOCK_20551151_ChIP-Seq_293T_Human1.91025653
21MYC_18555785_ChIP-Seq_MESCs_Mouse1.86351821
22TTF2_22483619_ChIP-Seq_HELA_Human1.70830778
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.66800443
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.63206448
25ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62033677
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60777600
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54032324
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53838152
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53758469
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.51785256
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.49676122
32E2F7_22180533_ChIP-Seq_HELA_Human1.48300634
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47582605
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46573510
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44305235
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43077207
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.36688075
38CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36054753
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29107504
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28054530
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.26433565
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25431251
43VDR_21846776_ChIP-Seq_THP-1_Human1.25108235
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23638112
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23271073
46CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23249103
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23012460
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22901908
49* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20852338
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20380165
51KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17631158
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17015597
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16035610
54E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14921651
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13371682
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12920181
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12259297
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12049050
59* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11744195
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11097333
61AR_21909140_ChIP-Seq_LNCAP_Human1.08262048
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07825312
63* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05888523
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04952773
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04676049
66HNF4A_19822575_ChIP-Seq_HepG2_Human1.03801115
67TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03349646
68SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01421336
69ZNF263_19887448_ChIP-Seq_K562_Human1.01234624
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00968192
71TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99741577
72* FOXP1_21924763_ChIP-Seq_HESCs_Human0.98507862
73* XRN2_22483619_ChIP-Seq_HELA_Human0.98447155
74ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97401954
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97148741
76SRF_21415370_ChIP-Seq_HL-1_Mouse0.95684631
77MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94829990
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.94746649
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94634575
80TFEB_21752829_ChIP-Seq_HELA_Human0.94560641
81* P68_20966046_ChIP-Seq_HELA_Human0.94162169
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.93893419
83ETS1_20019798_ChIP-Seq_JURKAT_Human0.93326241
84DCP1A_22483619_ChIP-Seq_HELA_Human0.92536376
85ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91814644
86* LXR_22292898_ChIP-Seq_THP-1_Human0.91729847
87PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91001174
88RARA_24833708_ChIP-Seq_LIVER_Mouse0.90922849
89EST1_17652178_ChIP-ChIP_JURKAT_Human0.89510375
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88660639
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84355720
92OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84284846
93GABP_17652178_ChIP-ChIP_JURKAT_Human0.83693759
94GABP_19822575_ChIP-Seq_HepG2_Human0.83432032
95* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83334463
96FOXA2_19822575_ChIP-Seq_HepG2_Human0.81792605
97GATA1_22025678_ChIP-Seq_K562_Human0.80130452
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79969475
99MYC_22102868_ChIP-Seq_BL_Human0.79916250
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79063631
101RARB_24833708_ChIP-Seq_LIVER_Mouse0.78064714
102TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77527828
103ATF3_27146783_Chip-Seq_COLON_Human0.77376939
104FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.76980746
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76573184
106HIF1A_21447827_ChIP-Seq_MCF-7_Human0.75185410
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74595534
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73835463
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73618995
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73313179
111NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73155662
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.72559403
113KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72522222
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.71270609
115NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.71109013
116RACK7_27058665_Chip-Seq_MCF-7_Human0.70784633
117HTT_18923047_ChIP-ChIP_STHdh_Human0.70206358
118POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.69709479
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.69467963
120MYCN_18555785_ChIP-Seq_MESCs_Mouse0.68744477
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.68419926
122FOXP3_21729870_ChIP-Seq_TREG_Human0.67165055
123* TET1_21451524_ChIP-Seq_MESCs_Mouse0.65488515
124PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.65367205
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.65065195
126GATA4_25053715_ChIP-Seq_YYC3_Human0.64348730
127SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.64122475
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.64040626
129KDM5A_27292631_Chip-Seq_BREAST_Human0.63409143
130NANOG_18555785_ChIP-Seq_MESCs_Mouse0.62761509
131SOX2_27498859_Chip-Seq_STOMACH_Mouse0.62074752
132RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61052738
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.60632370
134* BCL6_27268052_Chip-Seq_Bcells_Human0.60437194
135BRD4_27068464_Chip-Seq_AML-cells_Mouse0.59392517
136DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.59165172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.64516502
2MP0005360_urolithiasis6.88613621
3MP0005365_abnormal_bile_salt5.75721381
4MP0005085_abnormal_gallbladder_physiolo5.73395651
5MP0003806_abnormal_nucleotide_metabolis4.88502457
6MP0008875_abnormal_xenobiotic_pharmacok4.49300672
7MP0003693_abnormal_embryo_hatching3.77011937
8MP0010329_abnormal_lipoprotein_level3.46284201
9MP0009840_abnormal_foam_cell3.44252444
10MP0003252_abnormal_bile_duct3.43103930
11MP0003111_abnormal_nucleus_morphology3.42078613
12MP0010094_abnormal_chromosome_stability3.28208220
13MP0005083_abnormal_biliary_tract3.03115502
14MP0004957_abnormal_blastocyst_morpholog2.92082508
15MP0008932_abnormal_embryonic_tissue2.86081417
16MP0003077_abnormal_cell_cycle2.64671222
17MP0005332_abnormal_amino_acid2.58491923
18MP0005623_abnormal_meninges_morphology2.46899749
19MP0003705_abnormal_hypodermis_morpholog2.44045624
20MP0003191_abnormal_cellular_cholesterol2.33899516
21MP0001666_abnormal_nutrient_absorption2.31513655
22MP0002877_abnormal_melanocyte_morpholog2.29800998
23MP0008007_abnormal_cellular_replicative2.27830887
24MP0003195_calcinosis2.24758929
25MP0008058_abnormal_DNA_repair2.23360170
26MP0000609_abnormal_liver_physiology2.18056088
27MP0004233_abnormal_muscle_weight1.98558019
28MP0002118_abnormal_lipid_homeostasis1.92406592
29MP0005319_abnormal_enzyme/_coenzyme1.91337970
30MP0000537_abnormal_urethra_morphology1.90571640
31MP0004858_abnormal_nervous_system1.83448574
32MP0004272_abnormal_basement_membrane1.77847399
33MP0004019_abnormal_vitamin_homeostasis1.73358339
34MP0003186_abnormal_redox_activity1.70399576
35MP0000350_abnormal_cell_proliferation1.67631828
36MP0003315_abnormal_perineum_morphology1.67045359
37MP0001764_abnormal_homeostasis1.64529734
38MP0000566_synostosis1.59451443
39MP0005501_abnormal_skin_physiology1.57851049
40MP0005257_abnormal_intraocular_pressure1.53051531
41MP0009697_abnormal_copulation1.51386338
42MP0003786_premature_aging1.47840350
43MP0005584_abnormal_enzyme/coenzyme_acti1.47111051
44MP0003868_abnormal_feces_composition1.45487786
45MP0001849_ear_inflammation1.42154229
46MP0002080_prenatal_lethality1.39069186
47MP0004185_abnormal_adipocyte_glucose1.37901128
48MP0000598_abnormal_liver_morphology1.37614938
49MP0002138_abnormal_hepatobiliary_system1.36867747
50MP0003011_delayed_dark_adaptation1.35628941
51MP0000003_abnormal_adipose_tissue1.29146717
52MP0005380_embryogenesis_phenotype1.27456984
53MP0001672_abnormal_embryogenesis/_devel1.27456984
54MP0002249_abnormal_larynx_morphology1.27327080
55MP0000678_abnormal_parathyroid_gland1.26364643
56MP0000762_abnormal_tongue_morphology1.25219782
57MP0002234_abnormal_pharynx_morphology1.21842101
58MP0005670_abnormal_white_adipose1.21530142
59MP0008438_abnormal_cutaneous_collagen1.21152365
60MP0003656_abnormal_erythrocyte_physiolo1.19440791
61MP0001697_abnormal_embryo_size1.18596904
62MP0009643_abnormal_urine_homeostasis1.18470191
63MP0003984_embryonic_growth_retardation1.16322204
64MP0002697_abnormal_eye_size1.12724980
65MP0008789_abnormal_olfactory_epithelium1.11514907
66MP0008260_abnormal_autophagy1.10488079
67MP0001346_abnormal_lacrimal_gland1.10037780
68MP0003123_paternal_imprinting1.08112104
69MP0000490_abnormal_crypts_of1.07003368
70MP0002088_abnormal_embryonic_growth/wei1.06471125
71MP0002085_abnormal_embryonic_tissue1.06006941
72MP0009053_abnormal_anal_canal1.04660347
73MP0010368_abnormal_lymphatic_system1.04382744
74MP0010234_abnormal_vibrissa_follicle1.03765561
75MP0000313_abnormal_cell_death1.03494299
76MP0000467_abnormal_esophagus_morphology1.02643090
77MP0006036_abnormal_mitochondrial_physio1.01990751
78MP0000049_abnormal_middle_ear1.00705874
79MP0005076_abnormal_cell_differentiation0.99586493
80MP0009763_increased_sensitivity_to0.99177263
81MP0004197_abnormal_fetal_growth/weight/0.95271405
82MP0005451_abnormal_body_composition0.95142297
83MP0003385_abnormal_body_wall0.93688004
84MP0005647_abnormal_sex_gland0.92826048
85MP0000604_amyloidosis0.92086498
86MP0005376_homeostasis/metabolism_phenot0.91025994
87MP0000579_abnormal_nail_morphology0.90539869
88MP0002084_abnormal_developmental_patter0.88264527
89MP0005266_abnormal_metabolism0.87301661
90MP0002254_reproductive_system_inflammat0.86993065
91MP0008469_abnormal_protein_level0.86729587
92MP0005197_abnormal_uvea_morphology0.85195936
93MP0005384_cellular_phenotype0.85097291
94MP0000751_myopathy0.84467355
95MP0002111_abnormal_tail_morphology0.83759826
96MP0003942_abnormal_urinary_system0.83310302
97MP0005621_abnormal_cell_physiology0.83200786
98MP0002086_abnormal_extraembryonic_tissu0.81725006
99MP0005220_abnormal_exocrine_pancreas0.81289688
100MP0009642_abnormal_blood_homeostasis0.80327366
101MP0006035_abnormal_mitochondrial_morpho0.78169288
102MP0002092_abnormal_eye_morphology0.76825725
103MP0003115_abnormal_respiratory_system0.76448294
104MP0009764_decreased_sensitivity_to0.76117729
105MP0005636_abnormal_mineral_homeostasis0.75643653
106MP0001216_abnormal_epidermal_layer0.75090735
107MP0008057_abnormal_DNA_replication0.74424012
108MP0009672_abnormal_birth_weight0.72006861
109MP0005330_cardiomyopathy0.71912440
110MP0005394_taste/olfaction_phenotype0.71885344
111MP0005499_abnormal_olfactory_system0.71885344
112MP0005408_hypopigmentation0.71820826
113MP0005023_abnormal_wound_healing0.70805156
114MP0003937_abnormal_limbs/digits/tail_de0.70691322
115MP0010352_gastrointestinal_tract_polyps0.70592203
116MP0005084_abnormal_gallbladder_morpholo0.70084358
117MP0002019_abnormal_tumor_incidence0.69588399
118MP0005334_abnormal_fat_pad0.68710495
119MP0009384_cardiac_valve_regurgitation0.67511573
120MP0002078_abnormal_glucose_homeostasis0.66515586
121MP0002971_abnormal_brown_adipose0.65265187
122MP0001243_abnormal_dermal_layer0.64956697
123MP0001661_extended_life_span0.62725491
124MP0003279_aneurysm0.60519893
125MP0003436_decreased_susceptibility_to0.60066648
126MP0009765_abnormal_xenobiotic_induced0.59125454
127MP0003718_maternal_effect0.59110380
128MP0002970_abnormal_white_adipose0.58269542
129MP0000639_abnormal_adrenal_gland0.57892260
130MP0004130_abnormal_muscle_cell0.57277196
131MP0001756_abnormal_urination0.56724771
132MP0005464_abnormal_platelet_physiology0.55180535
133MP0005666_abnormal_adipose_tissue0.53988115
134MP0001853_heart_inflammation0.53952338
135MP0008873_increased_physiological_sensi0.53114253
136MP0002060_abnormal_skin_morphology0.53103084
137MP0005275_abnormal_skin_tensile0.52902118
138MP0001915_intracranial_hemorrhage0.51449845
139MP0009115_abnormal_fat_cell0.51242015
140MP0005448_abnormal_energy_balance0.49381600
141MP0005395_other_phenotype0.48803109
142MP0002269_muscular_atrophy0.46475007
143MP0004264_abnormal_extraembryonic_tissu0.46472096
144MP0002132_abnormal_respiratory_system0.44473144
145MP0000249_abnormal_blood_vessel0.42618932
146MP0005058_abnormal_lysosome_morphology0.42357533
147MP0002136_abnormal_kidney_physiology0.42081819
148MP0002796_impaired_skin_barrier0.41769300
149MP0002876_abnormal_thyroid_physiology0.40557210
150MP0003638_abnormal_response/metabolism_0.40516072
151MP0010030_abnormal_orbit_morphology0.40503001
152MP0000358_abnormal_cell_content/0.39392833
153MP0002135_abnormal_kidney_morphology0.39268156
154MP0003566_abnormal_cell_adhesion0.39051236
155MP0001881_abnormal_mammary_gland0.38346569
156MP0003329_amyloid_beta_deposits0.38044881
157MP0004883_abnormal_blood_vessel0.35664745
158MP0003724_increased_susceptibility_to0.33805223
159MP0003221_abnormal_cardiomyocyte_apopto0.33412012
160MP0005164_abnormal_response_to0.31983739
161MP0006082_CNS_inflammation0.31971797
162MP0001542_abnormal_bone_strength0.31801656
163MP0001845_abnormal_inflammatory_respons0.30971525
164MP0003953_abnormal_hormone_level0.29411832
165MP0001730_embryonic_growth_arrest0.29235948

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.85659369
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.78652850
3Intrahepatic cholestasis (HP:0001406)6.76686982
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.44896647
5Hypobetalipoproteinemia (HP:0003563)6.23258133
6Xanthomatosis (HP:0000991)5.91715606
7Prolonged partial thromboplastin time (HP:0003645)5.69090542
8Complement deficiency (HP:0004431)5.03944600
9Hyperlipoproteinemia (HP:0010980)4.98459904
10Hypolipoproteinemia (HP:0010981)4.65438239
11Hyperammonemia (HP:0001987)4.56121380
12Hyperglycinemia (HP:0002154)4.25621891
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.16080936
14Abnormality of the common coagulation pathway (HP:0010990)4.10885914
15Joint hemorrhage (HP:0005261)4.08079136
16Abnormality of sulfur amino acid metabolism (HP:0004339)4.06097150
17Epidermoid cyst (HP:0200040)4.03983753
18Hypoalphalipoproteinemia (HP:0003233)3.99149120
19Hyperglycinuria (HP:0003108)3.97873441
20Abnormality of pyrimidine metabolism (HP:0004353)3.97032839
21Ketosis (HP:0001946)3.95502948
22Abnormality of complement system (HP:0005339)3.92399963
23Abnormality of methionine metabolism (HP:0010901)3.88280198
24Abnormality of glycine metabolism (HP:0010895)3.86190050
25Abnormality of serine family amino acid metabolism (HP:0010894)3.86190050
26Abnormality of the intrinsic pathway (HP:0010989)3.83510608
27Fat malabsorption (HP:0002630)3.80796496
28Hypoglycemic coma (HP:0001325)3.76250785
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.65401186
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.64090852
31Premature rupture of membranes (HP:0001788)3.60261315
32Vertebral compression fractures (HP:0002953)3.51704835
33Trismus (HP:0000211)3.41110629
34Hypercholesterolemia (HP:0003124)3.38119563
35Microvesicular hepatic steatosis (HP:0001414)3.36202601
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34386297
37Abnormality of fatty-acid metabolism (HP:0004359)3.23152130
38Hyperbilirubinemia (HP:0002904)3.20019652
39Abnormality of serum amino acid levels (HP:0003112)2.97785946
40Steatorrhea (HP:0002570)2.96975198
41Abnormality of nucleobase metabolism (HP:0010932)2.95238015
42Conjugated hyperbilirubinemia (HP:0002908)2.94375532
43Skin nodule (HP:0200036)2.92977464
44Delayed CNS myelination (HP:0002188)2.90758847
45Ketoacidosis (HP:0001993)2.88317332
46Myocardial infarction (HP:0001658)2.86174748
47Abnormal gallbladder physiology (HP:0012438)2.86072470
48Cholecystitis (HP:0001082)2.86072470
49Progressive muscle weakness (HP:0003323)2.81096311
50Achilles tendon contracture (HP:0001771)2.79341100
51Systemic lupus erythematosus (HP:0002725)2.76100904
52Spastic diplegia (HP:0001264)2.75726400
53Hepatocellular carcinoma (HP:0001402)2.74651434
54Selective tooth agenesis (HP:0001592)2.72873196
55Dicarboxylic aciduria (HP:0003215)2.66144742
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66144742
57Proximal placement of thumb (HP:0009623)2.60151246
58Lethargy (HP:0001254)2.58680993
59Metabolic acidosis (HP:0001942)2.57761409
60Reduced antithrombin III activity (HP:0001976)2.57191149
61Abnormal gallbladder morphology (HP:0012437)2.55582894
62Cholelithiasis (HP:0001081)2.54036898
63Malnutrition (HP:0004395)2.51670963
64Deviation of the thumb (HP:0009603)2.51621010
65Opisthotonus (HP:0002179)2.48862725
66Hypochromic microcytic anemia (HP:0004840)2.48267435
67Hyperacusis (HP:0010780)2.45091688
68Abnormality of purine metabolism (HP:0004352)2.44340604
69Spontaneous abortion (HP:0005268)2.43497326
70Neonatal onset (HP:0003623)2.42144735
71Abnormal cartilage morphology (HP:0002763)2.40179886
72Rough bone trabeculation (HP:0100670)2.37944553
73Late onset (HP:0003584)2.36033885
74Abnormality of the umbilical cord (HP:0010881)2.35960969
75Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35511330
76Testicular atrophy (HP:0000029)2.30522099
77Mitral stenosis (HP:0001718)2.25871497
78Abnormality of the distal phalanges of the toes (HP:0010182)2.25765829
79Abnormal number of incisors (HP:0011064)2.24265963
80Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23543430
81Elbow flexion contracture (HP:0002987)2.22387098
82Broad distal phalanx of finger (HP:0009836)2.21709711
83Gout (HP:0001997)2.20566638
84Vascular calcification (HP:0004934)2.19808056
85Short nail (HP:0001799)2.19399500
86Cerebral edema (HP:0002181)2.19139630
87Irritability (HP:0000737)2.18218314
88Glomerulonephritis (HP:0000099)2.15911627
89Esophageal varix (HP:0002040)2.14400406
90Reticulocytopenia (HP:0001896)2.14012754
91Abnormality of the gallbladder (HP:0005264)2.13349096
92Hypoglycemic seizures (HP:0002173)2.13120627
93Type I transferrin isoform profile (HP:0003642)2.12501295
94Ulnar bowing (HP:0003031)2.12223047
95Abnormality of iron homeostasis (HP:0011031)2.10770239
96Brushfield spots (HP:0001088)2.08560636
97Cardiovascular calcification (HP:0011915)2.07511923
98Insomnia (HP:0100785)2.06514714
99Secondary amenorrhea (HP:0000869)2.06412831
100Back pain (HP:0003418)2.05703844
101Ragged-red muscle fibers (HP:0003200)2.03979392
102Abnormality of transition element cation homeostasis (HP:0011030)2.02776829
103Vomiting (HP:0002013)2.02385679
104Abnormality of cells of the erythroid lineage (HP:0012130)1.99393930
105Hypokinesia (HP:0002375)1.97176035
106Sensorimotor neuropathy (HP:0007141)1.97166142
107Acanthocytosis (HP:0001927)1.96334075
108Generalized aminoaciduria (HP:0002909)1.96305642
109Biconcave vertebral bodies (HP:0004586)1.96045702
110Pancreatitis (HP:0001733)1.95783727
111Breech presentation (HP:0001623)1.95240347
112Breast hypoplasia (HP:0003187)1.94665185
113Entropion (HP:0000621)1.93078078
114Generalized amyotrophy (HP:0003700)1.93065469
115Increased serum pyruvate (HP:0003542)1.92953766
116Abnormality of glycolysis (HP:0004366)1.92953766
117Microretrognathia (HP:0000308)1.92402824
118Absent epiphyses (HP:0010577)1.91393213
119Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91393213
120Spastic paraparesis (HP:0002313)1.91364463
121Abnormality of the Achilles tendon (HP:0005109)1.91157208
122Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90438442
123Amyloidosis (HP:0011034)1.89588619
124Abnormal mitochondria in muscle tissue (HP:0008316)1.88904965
125Reticulocytosis (HP:0001923)1.88288230
126Premature skin wrinkling (HP:0100678)1.87572286
127Increased serum ferritin (HP:0003281)1.87443755
128Hypertriglyceridemia (HP:0002155)1.87111010
129Sparse eyelashes (HP:0000653)1.86853031
130Thrombophlebitis (HP:0004418)1.86545951
131Protrusio acetabuli (HP:0003179)1.85983350
132Unilateral renal agenesis (HP:0000122)1.85935343
133Abnormal number of erythroid precursors (HP:0012131)1.85422367
134Abnormalities of placenta or umbilical cord (HP:0001194)1.84936199
135Nausea (HP:0002018)1.83699496
136Recurrent gram-negative bacterial infections (HP:0005420)1.83530067
137Abnormality of carpal bone ossification (HP:0006257)1.83460115
138Menorrhagia (HP:0000132)1.83092625
139Nonimmune hydrops fetalis (HP:0001790)1.82265623
140Hyperinsulinemic hypoglycemia (HP:0000825)1.81968747
141Peritonitis (HP:0002586)1.81270885
142Long palpebral fissure (HP:0000637)1.81019909
143Abnormal umbilical cord blood vessels (HP:0011403)1.80459467
144Single umbilical artery (HP:0001195)1.80459467
145Abnormality of the fetal cardiovascular system (HP:0010948)1.80459467
146Facial cleft (HP:0002006)1.79124466
147Gingival bleeding (HP:0000225)1.78670366
148Glossoptosis (HP:0000162)1.78229375
149Microglossia (HP:0000171)1.76945781
150Abnormality of dentin (HP:0010299)1.76922164
151Enlarged kidneys (HP:0000105)1.76914325
152Abnormality of reticulocytes (HP:0004312)1.75929296
153Epiphyseal stippling (HP:0010655)1.74894803
154Multiple enchondromatosis (HP:0005701)1.74122923
155Abnormal enzyme/coenzyme activity (HP:0012379)1.74009082
156Squamous cell carcinoma (HP:0002860)1.72759832
157Increased nuchal translucency (HP:0010880)1.72632751
158Abnormal trabecular bone morphology (HP:0100671)1.72535340
159Abnormality of the calcaneus (HP:0008364)1.71229095
160Self-mutilation (HP:0000742)1.70981132
161Chromsome breakage (HP:0040012)1.70774600
162Ankle contracture (HP:0006466)1.70548828
163Acute encephalopathy (HP:0006846)1.70379069
164Fragile skin (HP:0001030)1.69890574
165Birth length less than 3rd percentile (HP:0003561)1.69864711
166Abnormal delivery (HP:0001787)1.69742196
167High anterior hairline (HP:0009890)1.68357556
168Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.67920308
169Abnormal protein N-linked glycosylation (HP:0012347)1.67920308
170Abnormal protein glycosylation (HP:0012346)1.67920308
171Abnormal glycosylation (HP:0012345)1.67920308
172Renal duplication (HP:0000075)1.67803177
173Premature ovarian failure (HP:0008209)1.67289553
174Abnormality of the acetabulum (HP:0003170)1.65835911
175Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65803583
176Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65803583
177Abnormal ossification of hand bones (HP:0005921)1.64759328
178Pterygium (HP:0001059)1.63519060
179Hepatocellular necrosis (HP:0001404)1.62949671

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.12917402
2ERN15.36761490
3VRK23.61955262
4SIK13.55327885
5PKN23.29080154
6TRIB33.08376125
7SMG12.73413253
8FGFR42.68619113
9FLT32.52809921
10KDR2.42485636
11IRAK32.29768476
12TESK22.11753903
13MAP3K112.05918450
14SRPK11.96288900
15MAP2K31.84894255
16PBK1.81974949
17CDK81.76767986
18NEK11.74353531
19ERBB41.69156849
20BRSK11.63521995
21EIF2AK11.62187261
22LATS21.54404717
23ARAF1.50283612
24TAOK21.46272434
25ABL21.42117845
26BUB11.39588927
27NEK91.39275289
28LIMK11.37489222
29TYK21.34640152
30MAPK111.27803741
31NME21.25321757
32LATS11.22860033
33CHEK21.22839634
34MST1R1.20530431
35PTK61.17549551
36TAOK31.16266092
37EPHA21.16004012
38MAP2K41.12602040
39PIK3CG1.11728326
40MAP3K31.10129028
41GRK61.10123370
42ATR1.07296232
43MAP3K101.07156919
44CDK121.05070922
45AURKB1.05070212
46PRKD31.03487181
47RIPK10.96959377
48STK38L0.96008118
49PIM20.92281122
50BRAF0.92066789
51LMTK20.90913508
52CSNK1G30.90009585
53MAP3K80.89365819
54NME10.88189139
55RPS6KA40.88027521
56PAK40.87149634
57PDK20.86599015
58CDK60.85692214
59MET0.84088019
60CHEK10.84015995
61CDK40.83981539
62NEK20.83916594
63TESK10.82964641
64CDK70.79026989
65SCYL20.78120219
66TSSK60.77573510
67MAPKAPK30.77362098
68WEE10.76948492
69PRPF4B0.76704308
70PLK30.76398487
71TGFBR10.76176288
72STK100.76162550
73PTK20.74918072
74TBK10.74642492
75TGFBR20.74441688
76ILK0.73504766
77CSNK1A1L0.72452488
78LRRK20.72309478
79FGFR10.71377783
80BMX0.70275095
81NTRK10.69194206
82EEF2K0.68931031
83ZAP700.67040300
84VRK10.65204245
85MTOR0.64909825
86PLK40.64405774
87CAMK1D0.64067890
88CDK90.63867542
89JAK20.63613773
90RAF10.60581237
91CSF1R0.60029057
92EPHB20.58852062
93AKT20.56849783
94MAPK40.56542095
95BRSK20.56073854
96INSRR0.55957673
97TAF10.55403442
98CDK11A0.55377991
99MAP2K10.54453994
100PAK20.54213503
101PAK10.52535045
102PDGFRA0.52463162
103CDC70.52403897
104CSNK1G10.52188077
105TAOK10.51674713
106TTK0.51468213
107CDK150.51391810
108CDK140.50844306
109MATK0.49349692
110ERBB20.49300019
111CDK180.48866569
112MAP2K60.48617672
113CDK20.48306115
114MAP3K50.48042714
115CSNK2A20.47173085
116CDK10.46973777
117DAPK10.46812244
118FRK0.46658558
119PDK40.46602635
120PDK30.46602635
121RPS6KB20.45661826
122MAPKAPK50.45521399
123BLK0.42898671
124ACVR1B0.42259958
125ATM0.41581021
126DAPK30.41423876
127EIF2AK30.41382022
128AURKA0.41283775
129MAP4K10.40886287
130CSNK1G20.38825167
131GSK3A0.38796514
132STK40.38341286
133DAPK20.37445034
134PLK10.37348469
135KIT0.36965935
136MAP3K60.36524924
137IRAK20.35813253
138TTN0.35598938
139MAPK120.35477652
140STK160.34304666
141PRKCI0.34235769
142PRKACG0.33764915
143IGF1R0.33382166
144ICK0.33248843
145MAP2K70.32141250
146CSNK2A10.30333249
147STK30.30328926
148CSK0.30100094

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.15114696
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23427050
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22156748
4Nitrogen metabolism_Homo sapiens_hsa009103.04504099
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81219941
6Arginine biosynthesis_Homo sapiens_hsa002202.78096356
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.58802520
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56643509
9Complement and coagulation cascades_Homo sapiens_hsa046102.55723552
10Tryptophan metabolism_Homo sapiens_hsa003802.47785932
11Fatty acid degradation_Homo sapiens_hsa000712.44547936
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35247043
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17276185
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03119585
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.98970584
16Ribosome_Homo sapiens_hsa030101.96275313
17Peroxisome_Homo sapiens_hsa041461.96109388
18Propanoate metabolism_Homo sapiens_hsa006401.95230718
19Butanoate metabolism_Homo sapiens_hsa006501.86925273
20Caffeine metabolism_Homo sapiens_hsa002321.85053520
21Fatty acid metabolism_Homo sapiens_hsa012121.84212874
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84049566
23Chemical carcinogenesis_Homo sapiens_hsa052041.81321632
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79146532
25PPAR signaling pathway_Homo sapiens_hsa033201.79019003
26Selenocompound metabolism_Homo sapiens_hsa004501.75965383
27Nucleotide excision repair_Homo sapiens_hsa034201.71323231
28Spliceosome_Homo sapiens_hsa030401.70319099
29Biosynthesis of amino acids_Homo sapiens_hsa012301.66166588
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64791387
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.63880253
32Pyruvate metabolism_Homo sapiens_hsa006201.63228746
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.62143117
34Staphylococcus aureus infection_Homo sapiens_hsa051501.60979546
35Cell cycle_Homo sapiens_hsa041101.60545424
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59816570
37Histidine metabolism_Homo sapiens_hsa003401.59108509
38One carbon pool by folate_Homo sapiens_hsa006701.58627791
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57217652
40beta-Alanine metabolism_Homo sapiens_hsa004101.55225581
41Carbon metabolism_Homo sapiens_hsa012001.54187286
42Retinol metabolism_Homo sapiens_hsa008301.49446267
43Folate biosynthesis_Homo sapiens_hsa007901.48264493
44Phenylalanine metabolism_Homo sapiens_hsa003601.47851496
45RNA polymerase_Homo sapiens_hsa030201.39822737
46Sulfur relay system_Homo sapiens_hsa041221.39740295
47Non-homologous end-joining_Homo sapiens_hsa034501.36825910
48Tyrosine metabolism_Homo sapiens_hsa003501.34956797
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.32145482
50Homologous recombination_Homo sapiens_hsa034401.29949113
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29703308
52Bile secretion_Homo sapiens_hsa049761.26317167
53Fatty acid elongation_Homo sapiens_hsa000621.20403151
54Steroid biosynthesis_Homo sapiens_hsa001001.19849908
55Fat digestion and absorption_Homo sapiens_hsa049751.17840651
56Starch and sucrose metabolism_Homo sapiens_hsa005001.17820459
57Sulfur metabolism_Homo sapiens_hsa009201.16283490
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09356061
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07582388
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03377151
61Fanconi anemia pathway_Homo sapiens_hsa034601.01833931
62Vitamin B6 metabolism_Homo sapiens_hsa007501.00626911
63Arginine and proline metabolism_Homo sapiens_hsa003300.98694881
64Pentose phosphate pathway_Homo sapiens_hsa000300.94352525
65ABC transporters_Homo sapiens_hsa020100.84971656
66Glutathione metabolism_Homo sapiens_hsa004800.84483541
67Purine metabolism_Homo sapiens_hsa002300.83994342
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83167109
69Lysine degradation_Homo sapiens_hsa003100.76540715
70Vitamin digestion and absorption_Homo sapiens_hsa049770.75086281
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.72551447
72Parkinsons disease_Homo sapiens_hsa050120.68825559
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64169364
74Glycerolipid metabolism_Homo sapiens_hsa005610.63503314
75mRNA surveillance pathway_Homo sapiens_hsa030150.62982077
76Fatty acid biosynthesis_Homo sapiens_hsa000610.61446220
77Oxidative phosphorylation_Homo sapiens_hsa001900.61420861
78Fructose and mannose metabolism_Homo sapiens_hsa000510.59995448
79Huntingtons disease_Homo sapiens_hsa050160.59603721
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59530458
81Galactose metabolism_Homo sapiens_hsa000520.58316031
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58234804
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53566862
84Metabolic pathways_Homo sapiens_hsa011000.52865793
85Other glycan degradation_Homo sapiens_hsa005110.52711535
86p53 signaling pathway_Homo sapiens_hsa041150.52583577
87Vibrio cholerae infection_Homo sapiens_hsa051100.52104721
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47433052
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45736104
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37284902
91Small cell lung cancer_Homo sapiens_hsa052220.35539747
92Prion diseases_Homo sapiens_hsa050200.34726279
93Alzheimers disease_Homo sapiens_hsa050100.34439233
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34005925
95Proteasome_Homo sapiens_hsa030500.31199184
96Protein export_Homo sapiens_hsa030600.30697407
97RNA degradation_Homo sapiens_hsa030180.27489800
98Pyrimidine metabolism_Homo sapiens_hsa002400.26217573
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25601557
100Chronic myeloid leukemia_Homo sapiens_hsa052200.23809090
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19632574
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.18480759
103DNA replication_Homo sapiens_hsa030300.15199480
104Insulin resistance_Homo sapiens_hsa049310.14454846
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.13794023
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11836349
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.10428379
108Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.09659460
109Linoleic acid metabolism_Homo sapiens_hsa005910.08499121
110Bladder cancer_Homo sapiens_hsa052190.05158306
111Glucagon signaling pathway_Homo sapiens_hsa049220.03623031
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.03202891
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.02119335
114AMPK signaling pathway_Homo sapiens_hsa041520.01591431
115Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1407459
116RNA transport_Homo sapiens_hsa03013-0.1052510
117Insulin signaling pathway_Homo sapiens_hsa04910-0.0930525
118N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0873171
119Legionellosis_Homo sapiens_hsa05134-0.0705787
120Renin-angiotensin system_Homo sapiens_hsa04614-0.0667712
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0541767
122Thyroid cancer_Homo sapiens_hsa05216-0.0461228
123Base excision repair_Homo sapiens_hsa03410-0.0448446
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0347132
125Mismatch repair_Homo sapiens_hsa03430-0.0277750

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