SIK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of odontogenesis (GO:0042482)5.78711393
2negative regulation of complement activation (GO:0045916)5.70470055
3homocysteine metabolic process (GO:0050667)5.37072762
4negative regulation of protein activation cascade (GO:2000258)5.04038185
5midgut development (GO:0007494)4.96858343
6negative regulation of humoral immune response (GO:0002921)4.65847152
7response to dexamethasone (GO:0071548)4.56169369
8cAMP catabolic process (GO:0006198)4.42010584
9urea cycle (GO:0000050)4.38854405
10negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.23607429
11establishment of skin barrier (GO:0061436)4.23095746
12keratinocyte development (GO:0003334)4.10746855
13polarized epithelial cell differentiation (GO:0030859)4.06126967
14hepatocyte differentiation (GO:0070365)3.98833549
15peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.89508383
16positive regulation of vascular permeability (GO:0043117)3.89301997
17cyclic nucleotide catabolic process (GO:0009214)3.83510500
18urea metabolic process (GO:0019627)3.83118940
19embryonic process involved in female pregnancy (GO:0060136)3.80295073
20citrulline biosynthetic process (GO:0019240)3.78788470
21surfactant homeostasis (GO:0043129)3.71881640
22regulation of water loss via skin (GO:0033561)3.68637489
23hemidesmosome assembly (GO:0031581)3.65898978
24positive regulation of astrocyte differentiation (GO:0048711)3.60954121
25response to growth hormone (GO:0060416)3.58384135
26cellular response to fluid shear stress (GO:0071498)3.55888076
27citrulline metabolic process (GO:0000052)3.50774154
28regulation of gamma-delta T cell differentiation (GO:0045586)3.50399120
29keratinization (GO:0031424)3.43128715
30positive thymic T cell selection (GO:0045059)3.42629672
31pathway-restricted SMAD protein phosphorylation (GO:0060389)3.42122444
32pericardium development (GO:0060039)3.40718960
33regulation of p38MAPK cascade (GO:1900744)3.38881138
34regulation of gamma-delta T cell activation (GO:0046643)3.36885361
35cellular response to antibiotic (GO:0071236)3.36226792
36response to muramyl dipeptide (GO:0032495)3.35831364
37nitrogen cycle metabolic process (GO:0071941)3.26328281
38establishment of apical/basal cell polarity (GO:0035089)3.25988059
39definitive hemopoiesis (GO:0060216)3.23299254
40lymph vessel development (GO:0001945)3.19972137
41basement membrane organization (GO:0071711)3.18721861
42regulation of glucocorticoid metabolic process (GO:0031943)3.18291221
43positive regulation of gamma-delta T cell activation (GO:0046645)3.16928745
44radial glial cell differentiation (GO:0060019)3.15406644
45antigen processing and presentation of endogenous antigen (GO:0019883)3.14284885
46positive regulation of osteoblast proliferation (GO:0033690)3.13006595
47regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.11631039
48endothelial cell chemotaxis (GO:0035767)3.04923224
49regulation of steroid hormone biosynthetic process (GO:0090030)3.04454394
50response to food (GO:0032094)3.01180426
51negative regulation of erythrocyte differentiation (GO:0045647)2.99493393
52interferon-gamma production (GO:0032609)2.99092655
53regulation of histone H3-K27 methylation (GO:0061085)2.97094053
54negative regulation of glycoprotein biosynthetic process (GO:0010561)2.97008750
55cornea development in camera-type eye (GO:0061303)2.95348172
56negative regulation of stress fiber assembly (GO:0051497)2.94259528
57receptor catabolic process (GO:0032801)2.93839072
58cellular response to epinephrine stimulus (GO:0071872)2.92981849
59positive regulation of p38MAPK cascade (GO:1900745)2.92497206
60interferon-gamma secretion (GO:0072643)2.91133763
61thymic T cell selection (GO:0045061)2.90109869
62bundle of His cell to Purkinje myocyte communication (GO:0086069)2.88734535
63desmosome organization (GO:0002934)2.83809239
64peptide cross-linking (GO:0018149)2.81144582
65germ cell migration (GO:0008354)2.80719681
66viral transcription (GO:0019083)2.80651563
67renal absorption (GO:0070293)2.80551168
68branching involved in salivary gland morphogenesis (GO:0060445)2.79238611
69histone H3-K36 demethylation (GO:0070544)2.79090816
70regulation of interleukin-12 biosynthetic process (GO:0045075)2.77360341
71negative regulation of granulocyte differentiation (GO:0030853)2.77108009
72lung vasculature development (GO:0060426)2.76924439
73negative regulation of smooth muscle cell proliferation (GO:0048662)2.75592288
74positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.75471207
75keratinocyte proliferation (GO:0043616)2.75028852
76retina vasculature morphogenesis in camera-type eye (GO:0061299)2.73300959
77chemical homeostasis within a tissue (GO:0048875)2.71788334
78cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.70942628
79heart valve morphogenesis (GO:0003179)2.69547841
80NIK/NF-kappaB signaling (GO:0038061)2.68389868
81tolerance induction (GO:0002507)2.65011386
82cellular response to arsenic-containing substance (GO:0071243)2.64608740
83response to fluid shear stress (GO:0034405)2.64349423
84positive T cell selection (GO:0043368)2.63808337
85T-helper cell differentiation (GO:0042093)2.63563539
86CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.63563539
87cell migration involved in sprouting angiogenesis (GO:0002042)2.63382580
88iron ion import (GO:0097286)2.62357557
89keratinocyte differentiation (GO:0030216)2.61395313
90negative regulation of hormone biosynthetic process (GO:0032353)2.61245093
91regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.61182825
92regulation of cholesterol homeostasis (GO:2000188)2.60747081
93trophectodermal cell differentiation (GO:0001829)2.59215439
94response to laminar fluid shear stress (GO:0034616)2.59088304
95platelet-derived growth factor receptor signaling pathway (GO:0048008)2.58820730
96JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.58746406
97positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.57285995
98establishment of epithelial cell polarity (GO:0090162)2.56982007
99T cell selection (GO:0045058)2.55859058
100translational termination (GO:0006415)2.55801447
101negative regulation of protein autophosphorylation (GO:0031953)2.55000704
102neural crest cell development (GO:0014032)2.54189878
103regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.53155368
104nuclear pore complex assembly (GO:0051292)2.52829539
105antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50935755
106antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.50935755
107negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.50856475
108negative regulation of activin receptor signaling pathway (GO:0032926)2.50403202
109response to epinephrine (GO:0071871)2.49795644
110low-density lipoprotein particle clearance (GO:0034383)2.49425988
111negative regulation of TOR signaling (GO:0032007)2.49340240
112mature B cell differentiation (GO:0002335)2.49187867
113cardiac epithelial to mesenchymal transition (GO:0060317)2.49165224
114endothelial cell development (GO:0001885)2.49090445
115negative regulation of fatty acid transport (GO:2000192)2.49001906
116negative regulation of interleukin-8 production (GO:0032717)2.48525152
117positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.47462835
118regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.47462835
119skeletal muscle cell differentiation (GO:0035914)2.47449483
120embryonic placenta development (GO:0001892)2.47242628
121snRNA transcription (GO:0009301)2.47153840
122eyelid development in camera-type eye (GO:0061029)2.47063695
123vascular endothelial growth factor signaling pathway (GO:0038084)2.46956173
124pattern specification involved in kidney development (GO:0061004)2.46336959
125cellular response to toxic substance (GO:0097237)2.45682168
126negative regulation of hormone metabolic process (GO:0032351)2.45492711
127Rap protein signal transduction (GO:0032486)2.45335815
128positive regulation of cartilage development (GO:0061036)2.44630607
129facial nerve structural organization (GO:0021612)2.44101428
130ribosomal small subunit biogenesis (GO:0042274)2.43770808
131positive regulation of CREB transcription factor activity (GO:0032793)2.43260130
132negative regulation of vascular permeability (GO:0043116)2.43133311
133cell-substrate junction assembly (GO:0007044)2.42495980
134mRNA transcription (GO:0009299)2.41810476
135morphogenesis of an epithelial sheet (GO:0002011)2.40345428
136mesodermal cell differentiation (GO:0048333)2.37892551
137alpha-beta T cell differentiation involved in immune response (GO:0002293)2.37228011
138alpha-beta T cell activation involved in immune response (GO:0002287)2.37228011
139T cell differentiation involved in immune response (GO:0002292)2.37228011
140cellular response to dexamethasone stimulus (GO:0071549)2.36864004
141mRNA transcription from RNA polymerase II promoter (GO:0042789)2.36837892
142regulation of cell proliferation involved in kidney development (GO:1901722)2.36790918
143protein destabilization (GO:0031648)2.36361656
144response to progesterone (GO:0032570)2.36156208
145establishment of endothelial barrier (GO:0061028)2.35727271
146ovulation from ovarian follicle (GO:0001542)2.35118895
147hepatocyte apoptotic process (GO:0097284)2.33118500
148negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.31937589
149positive regulation of histone deacetylation (GO:0031065)2.28782127
150gland morphogenesis (GO:0022612)2.27775517
151blood vessel endothelial cell migration (GO:0043534)2.26807375
152positive regulation of mRNA catabolic process (GO:0061014)2.26261049
153antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.23101357
154Notch signaling involved in heart development (GO:0061314)2.22844279
155alpha-beta T cell differentiation (GO:0046632)2.22774739
156endoderm formation (GO:0001706)2.22402460
157branching involved in labyrinthine layer morphogenesis (GO:0060670)2.21670065
158T cell differentiation (GO:0030217)2.18494331
159growth hormone receptor signaling pathway (GO:0060396)2.17513625
160response to interleukin-15 (GO:0070672)2.17359952
161regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.17355479
162apoptotic process involved in morphogenesis (GO:0060561)2.16861374
163atrioventricular valve morphogenesis (GO:0003181)2.11847276
164regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.09731666
165alpha-beta T cell activation (GO:0046631)2.09540722
166mature B cell differentiation involved in immune response (GO:0002313)2.08255758
167positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.08060637
168negative regulation of actin filament bundle assembly (GO:0032232)2.07988158
169trabecula morphogenesis (GO:0061383)2.07907565
170T cell differentiation in thymus (GO:0033077)2.07831763
171angiogenesis involved in wound healing (GO:0060055)2.07347982
172fibroblast migration (GO:0010761)2.06852484
173muscle organ morphogenesis (GO:0048644)2.06709484
174cell surface receptor signaling pathway involved in heart development (GO:0061311)2.06693556
175face development (GO:0060324)2.06575891
176negative regulation of bone resorption (GO:0045779)2.06008220
177endothelial tube morphogenesis (GO:0061154)2.05698400
178morphogenesis of an endothelium (GO:0003159)2.05698400
179lymphoid progenitor cell differentiation (GO:0002320)2.05587578
180bone remodeling (GO:0046849)2.05121438
181germinal center formation (GO:0002467)2.04469902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.70411526
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.24721112
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.08873037
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67053901
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.25059325
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.24173283
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.24173283
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.24173283
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15322977
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.13877673
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.01548933
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.71975916
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.62005580
14SCL_19346495_ChIP-Seq_HPC-7_Human2.53262850
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.38481504
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38253191
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.37697018
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.29610129
19TCF7_22412390_ChIP-Seq_EML_Mouse2.24606457
20* MYC_22102868_ChIP-Seq_BL_Human2.23843404
21* ESR1_21235772_ChIP-Seq_MCF-7_Human2.14021173
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.12593850
23RUNX_20019798_ChIP-Seq_JUKART_Human2.11647166
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.11262829
25STAT6_21828071_ChIP-Seq_BEAS2B_Human2.05053366
26TRIM28_21343339_ChIP-Seq_HEK293_Human2.03725845
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02525798
28* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.00114235
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.97163571
30MAF_26560356_Chip-Seq_TH1_Human1.91062283
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89229993
32VDR_21846776_ChIP-Seq_THP-1_Human1.88072283
33CLOCK_20551151_ChIP-Seq_293T_Human1.80193353
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.77777688
35* ESR2_21235772_ChIP-Seq_MCF-7_Human1.73554354
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.64734038
37AHR_22903824_ChIP-Seq_MCF-7_Human1.62926993
38SOX9_24532713_ChIP-Seq_HFSC_Mouse1.61744739
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60580442
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57902450
41MYB_26560356_Chip-Seq_TH2_Human1.57617141
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55312937
43SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55312937
44* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53697359
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50418360
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50192360
47* KDM2B_26808549_Chip-Seq_DND41_Human1.49604317
48MYB_26560356_Chip-Seq_TH1_Human1.48497313
49VDR_24763502_ChIP-Seq_THP-1_Human1.46846575
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.46793061
51* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44633115
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44282970
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43034486
54HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.42874290
55ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.39886441
56UTX_26944678_Chip-Seq_JUKART_Human1.39445930
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38279739
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36823067
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36422477
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.36372049
61* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36282494
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35394238
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32687245
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32227826
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30339039
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30079673
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.29498096
68LXR_22292898_ChIP-Seq_THP-1_Human1.27894516
69* RUNX1_27514584_Chip-Seq_MCF-7_Human1.27768083
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27014704
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25979367
72TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25744669
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25659964
74CREB1_26743006_Chip-Seq_LNCaP_Human1.25202766
75* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24008966
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21615784
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21152448
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.21048299
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.19873701
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.19078022
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.18847952
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18771920
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18759204
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18739294
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.17744619
86* RACK7_27058665_Chip-Seq_MCF-7_Human1.17277835
87FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15810882
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14725182
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14059446
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.13088079
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12761495
92* SMC4_20622854_ChIP-Seq_HELA_Human1.12631430
93P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10655864
94KLF5_25053715_ChIP-Seq_YYC3_Human1.10506467
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.10380248
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10224401
97GATA6_25053715_ChIP-Seq_YYC3_Human1.09701983
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08881832
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.08730203
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08650305
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08406177
102SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08093214
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07961166
104SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07298294
105* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07169576
106SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06851809
107EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06412306
108* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04730078
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04494520
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.03737468
111PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02984856
112CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02745353
113MAF_26560356_Chip-Seq_TH2_Human1.02301931
114VDR_24787735_ChIP-Seq_THP-1_Human1.01552133
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01234644
116* NCOR1_26117541_ChIP-Seq_K562_Human1.00361386
117CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00281006
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99605957
119SMAD_19615063_ChIP-ChIP_OVARY_Human0.97464043
120ZNF263_19887448_ChIP-Seq_K562_Human0.96483560
121ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96177035
122TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95770236
123SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94967306
124* KDM2B_26808549_Chip-Seq_K562_Human0.94756908
125CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94174706
126FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92779153
127CJUN_26792858_Chip-Seq_BT549_Human0.92376445
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91486914
129* LXR_22158963_ChIP-Seq_LIVER_Mouse0.91353350
130FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89933108
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88327430
132ATF3_27146783_Chip-Seq_COLON_Human0.87625806
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85217753
134* TBX20_22080862_ChIP-Seq_HEART_Mouse0.85067827
135* TBX20_22328084_ChIP-Seq_HEART_Mouse0.85067827
136* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.84843169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.46803466
2MP0005083_abnormal_biliary_tract3.39953159
3MP0003724_increased_susceptibility_to3.11688844
4MP0000579_abnormal_nail_morphology3.04096519
5MP0000013_abnormal_adipose_tissue2.51444010
6MP0003828_pulmonary_edema2.37026729
7MP0000685_abnormal_immune_system2.31185877
8MP0000003_abnormal_adipose_tissue2.26619674
9MP0002009_preneoplasia2.23242656
10MP0003303_peritoneal_inflammation2.20164903
11MP0003763_abnormal_thymus_physiology2.01940156
12MP0004381_abnormal_hair_follicle2.01059170
13MP0009278_abnormal_bone_marrow2.00348951
14MP0003705_abnormal_hypodermis_morpholog1.95013627
15MP0002166_altered_tumor_susceptibility1.92947759
16MP0002796_impaired_skin_barrier1.92194228
17MP0004510_myositis1.90917302
18MP0003941_abnormal_skin_development1.86366374
19MP0003453_abnormal_keratinocyte_physiol1.83279568
20MP0005387_immune_system_phenotype1.81557175
21MP0001790_abnormal_immune_system1.81557175
22MP0003950_abnormal_plasma_membrane1.78548155
23MP0010368_abnormal_lymphatic_system1.78250669
24MP0001800_abnormal_humoral_immune1.67989567
25MP0002138_abnormal_hepatobiliary_system1.66285254
26MP0004233_abnormal_muscle_weight1.65296686
27MP0006138_congestive_heart_failure1.64788276
28MP0001873_stomach_inflammation1.62778979
29MP0001879_abnormal_lymphatic_vessel1.61994368
30MP0008995_early_reproductive_senescence1.61528191
31MP0001835_abnormal_antigen_presentation1.60941311
32MP0002060_abnormal_skin_morphology1.57874565
33MP0010771_integument_phenotype1.54182468
34MP0003566_abnormal_cell_adhesion1.52794098
35MP0008057_abnormal_DNA_replication1.50669781
36MP0003136_yellow_coat_color1.50250448
37MP0002405_respiratory_system_inflammati1.48601872
38MP0001851_eye_inflammation1.48108653
39MP0010155_abnormal_intestine_physiology1.47967297
40MP0009840_abnormal_foam_cell1.46816010
41MP0005375_adipose_tissue_phenotype1.44105293
42MP0005076_abnormal_cell_differentiation1.43138123
43MP0003436_decreased_susceptibility_to1.42724395
44MP0003300_gastrointestinal_ulcer1.42501749
45MP0004782_abnormal_surfactant_physiolog1.42361889
46MP0009379_abnormal_foot_pigmentation1.42215247
47MP0001853_heart_inflammation1.40179961
48MP0004947_skin_inflammation1.38737782
49MP0010352_gastrointestinal_tract_polyps1.38417513
50MP0002006_tumorigenesis1.38253358
51MP0005000_abnormal_immune_tolerance1.33435054
52MP0001216_abnormal_epidermal_layer1.32212653
53MP0004808_abnormal_hematopoietic_stem1.31519773
54MP0002877_abnormal_melanocyte_morpholog1.31230495
55MP0000383_abnormal_hair_follicle1.30739204
56MP0002396_abnormal_hematopoietic_system1.29980299
57MP0002452_abnormal_antigen_presenting1.29166119
58MP0002277_abnormal_respiratory_mucosa1.25386706
59MP0000733_abnormal_muscle_development1.25022297
60MP0002723_abnormal_immune_serum1.24873628
61MP0000465_gastrointestinal_hemorrhage1.21869472
62MP0005501_abnormal_skin_physiology1.21173986
63MP0002098_abnormal_vibrissa_morphology1.19958218
64MP0000467_abnormal_esophagus_morphology1.18334379
65MP0005397_hematopoietic_system_phenotyp1.16560924
66MP0001545_abnormal_hematopoietic_system1.16560924
67MP0004272_abnormal_basement_membrane1.15308528
68MP0002420_abnormal_adaptive_immunity1.13701983
69MP0000767_abnormal_smooth_muscle1.13068503
70MP0001346_abnormal_lacrimal_gland1.12983425
71MP0003448_altered_tumor_morphology1.11946485
72MP0001819_abnormal_immune_cell1.11418356
73MP0005623_abnormal_meninges_morphology1.09840982
74MP0005023_abnormal_wound_healing1.06813187
75MP0005025_abnormal_response_to1.06138827
76MP0002933_joint_inflammation1.06039050
77MP0000490_abnormal_crypts_of1.05420219
78MP0000703_abnormal_thymus_morphology1.05323521
79MP0005671_abnormal_response_to1.05230613
80MP0000367_abnormal_coat/_hair1.04587516
81MP0002398_abnormal_bone_marrow1.03958446
82MP0002148_abnormal_hypersensitivity_rea1.01971246
83MP0005647_abnormal_sex_gland1.01397902
84MP0008961_abnormal_basal_metabolism1.01103307
85MP0002249_abnormal_larynx_morphology1.00632923
86MP0005367_renal/urinary_system_phenotyp1.00137903
87MP0000516_abnormal_urinary_system1.00137903
88MP0009333_abnormal_splenocyte_physiolog0.99387013
89MP0009785_altered_susceptibility_to0.98577396
90MP0001661_extended_life_span0.98113834
91MP0000716_abnormal_immune_system0.97482350
92MP0008004_abnormal_stomach_pH0.97075785
93MP0000750_abnormal_muscle_regeneration0.96692670
94MP0000566_synostosis0.95613386
95MP0003866_abnormal_defecation0.94761550
96MP0000858_altered_metastatic_potential0.93332574
97MP0005334_abnormal_fat_pad0.92763447
98MP0010678_abnormal_skin_adnexa0.92655300
99MP0005451_abnormal_body_composition0.92575588
100MP0003011_delayed_dark_adaptation0.91747979
101MP0000377_abnormal_hair_follicle0.91515355
102MP0002722_abnormal_immune_system0.91350866
103MP0005275_abnormal_skin_tensile0.90088491
104MP0001348_abnormal_lacrimal_gland0.89339017
105MP0005164_abnormal_response_to0.89022104
106MP0000689_abnormal_spleen_morphology0.88384787
107MP0001958_emphysema0.87355659
108MP0004084_abnormal_cardiac_muscle0.86753935
109MP0005409_darkened_coat_color0.86546138
110MP0009931_abnormal_skin_appearance0.85339807
111MP0001845_abnormal_inflammatory_respons0.84764121
112MP0010307_abnormal_tumor_latency0.84466057
113MP0001243_abnormal_dermal_layer0.84191570
114MP0003279_aneurysm0.83854977
115MP0002998_abnormal_bone_remodeling0.83726919
116MP0000762_abnormal_tongue_morphology0.83353945
117MP0000249_abnormal_blood_vessel0.83214921
118MP0003786_premature_aging0.83171921
119MP0005174_abnormal_tail_pigmentation0.82815805
120MP0008438_abnormal_cutaneous_collagen0.81469290
121MP0005621_abnormal_cell_physiology0.80728901
122MP0002089_abnormal_postnatal_growth/wei0.80531699
123MP0001191_abnormal_skin_condition0.80469972
124MP0010630_abnormal_cardiac_muscle0.79931998
125MP0010234_abnormal_vibrissa_follicle0.79731489
126MP0002419_abnormal_innate_immunity0.78647196
127MP0005220_abnormal_exocrine_pancreas0.78625913
128MP0002429_abnormal_blood_cell0.78230954
129MP0003091_abnormal_cell_migration0.77976743
130MP0002925_abnormal_cardiovascular_devel0.77247446
131MP0002896_abnormal_bone_mineralization0.76169039
132MP0000613_abnormal_salivary_gland0.75266620
133MP0000627_abnormal_mammary_gland0.75248562
134MP0002970_abnormal_white_adipose0.74898762
135MP0001784_abnormal_fluid_regulation0.74709014
136MP0003045_fibrosis0.74277236
137MP0010030_abnormal_orbit_morphology0.73427237
138MP0005595_abnormal_vascular_smooth0.72776624
139MP0008260_abnormal_autophagy0.71158967
140MP0001502_abnormal_circadian_rhythm0.69697462
141MP0009115_abnormal_fat_cell0.67076867
142MP0004087_abnormal_muscle_fiber0.65207437
143MP0002086_abnormal_extraembryonic_tissu0.65187617
144MP0005666_abnormal_adipose_tissue0.61921822
145MP0005423_abnormal_somatic_nervous0.61713698
146MP0000427_abnormal_hair_cycle0.59445608
147MP0002332_abnormal_exercise_endurance0.59421630
148MP0002136_abnormal_kidney_physiology0.58593102

Predicted human phenotypes

RankGene SetZ-score
1Sparse lateral eyebrow (HP:0005338)3.53388473
2Cerebellar dysplasia (HP:0007033)3.50842263
3Natal tooth (HP:0000695)3.41176199
4Lip pit (HP:0100267)3.31077990
5Asymmetry of the thorax (HP:0001555)3.17748069
6Milia (HP:0001056)3.13499702
7Palmoplantar hyperkeratosis (HP:0000972)3.08324777
8Interstitial pulmonary disease (HP:0006530)3.04754025
9Alkalosis (HP:0001948)3.01535902
10Muscle fiber atrophy (HP:0100295)2.98089002
11Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.83959958
12Abnormality of the neuromuscular junction (HP:0003398)2.83523332
13Fatigable weakness (HP:0003473)2.83523332
14Nasolacrimal duct obstruction (HP:0000579)2.81303682
15Elbow flexion contracture (HP:0002987)2.80476086
16Right ventricular cardiomyopathy (HP:0011663)2.80140592
17Distal lower limb muscle weakness (HP:0009053)2.78441290
18Broad face (HP:0000283)2.77801415
19Palmar hyperkeratosis (HP:0010765)2.77780779
20Myositis (HP:0100614)2.77058028
21Abnormality of nail color (HP:0100643)2.75444401
22Onycholysis (HP:0001806)2.72147575
23Orchitis (HP:0100796)2.67636290
24Type 2 muscle fiber atrophy (HP:0003554)2.66200778
25Increased connective tissue (HP:0009025)2.64224777
26Persistence of primary teeth (HP:0006335)2.63748836
27Weak cry (HP:0001612)2.57533217
28Advanced eruption of teeth (HP:0006288)2.57147060
29Partial agenesis of the corpus callosum (HP:0001338)2.56170635
30Increased density of long bones (HP:0006392)2.54312693
31Wide intermamillary distance (HP:0006610)2.54248192
32Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51040477
33Agammaglobulinemia (HP:0004432)2.50160228
34Abnormality of the nasal mucosa (HP:0000433)2.49885505
35Increased IgE level (HP:0003212)2.48768107
36Spontaneous hematomas (HP:0007420)2.46919784
37Nail dystrophy (HP:0008404)2.45772624
38Round ear (HP:0100830)2.44485133
39Submucous cleft hard palate (HP:0000176)2.44099298
40Colitis (HP:0002583)2.43800694
41Ureteral duplication (HP:0000073)2.42621150
42Distal lower limb amyotrophy (HP:0008944)2.40440842
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.39858627
44Osteolytic defects of the hand bones (HP:0009699)2.39858627
45Cellulitis (HP:0100658)2.39189120
46Ventricular tachycardia (HP:0004756)2.38254376
47Popliteal pterygium (HP:0009756)2.37271303
48Hyporeflexia of lower limbs (HP:0002600)2.37189252
49Eczematoid dermatitis (HP:0000976)2.36415705
50Fair hair (HP:0002286)2.34748560
51Abnormality of the fingertips (HP:0001211)2.33435533
52IgM deficiency (HP:0002850)2.32397310
53Progressive muscle weakness (HP:0003323)2.29319541
54Malnutrition (HP:0004395)2.29141911
55Optic neuritis (HP:0100653)2.28103913
56Retrobulbar optic neuritis (HP:0100654)2.28103913
57Inflammation of the large intestine (HP:0002037)2.27852254
58Ulnar bowing (HP:0003031)2.26522170
59Atrophic scars (HP:0001075)2.26323666
60Malignant hyperthermia (HP:0002047)2.25348649
61Keratoconjunctivitis (HP:0001096)2.24910069
62Recurrent fungal infections (HP:0002841)2.24609697
63Recurrent cutaneous fungal infections (HP:0011370)2.23272407
64Chronic mucocutaneous candidiasis (HP:0002728)2.23272407
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.22979275
66Easy fatigability (HP:0003388)2.22018959
67Stroke (HP:0001297)2.19625553
68Hematochezia (HP:0002573)2.19179108
69Muscle fiber splitting (HP:0003555)2.17956544
70Pustule (HP:0200039)2.17251036
71Plantar hyperkeratosis (HP:0007556)2.16601403
72Duplicated collecting system (HP:0000081)2.15920944
73Hypoplasia of dental enamel (HP:0006297)2.15222499
74Abnormality of the distal phalanges of the toes (HP:0010182)2.15199921
75Meningitis (HP:0001287)2.14562380
76Dislocated radial head (HP:0003083)2.14246879
77Nonprogressive disorder (HP:0003680)2.13732001
78Hypotrichosis (HP:0001006)2.13038565
79Abnormality of the labia majora (HP:0012881)2.11418837
80Short nail (HP:0001799)2.10749647
81Subacute progressive viral hepatitis (HP:0006572)2.10385824
82Vertebral arch anomaly (HP:0008438)2.09972232
83Short chin (HP:0000331)2.09897541
84Corneal erosion (HP:0200020)2.09820844
85Depressed nasal tip (HP:0000437)2.06403421
86Pterygium (HP:0001059)2.03520219
87Elevated erythrocyte sedimentation rate (HP:0003565)2.02806669
88Fibular hypoplasia (HP:0003038)2.02777420
89Selective tooth agenesis (HP:0001592)2.02531719
90Ankyloglossia (HP:0010296)2.02030119
91Dysmetric saccades (HP:0000641)2.01874228
92Gastrointestinal inflammation (HP:0004386)2.01336620
93Aplasia cutis congenita (HP:0001057)2.01129814
94Prolonged bleeding time (HP:0003010)1.99946843
95Abnormal hair laboratory examination (HP:0003328)1.98591261
96Abnormality of the salivary glands (HP:0010286)1.97344888
97Abnormal hemoglobin (HP:0011902)1.97307599
98Ridged nail (HP:0001807)1.97236169
99Fragile nails (HP:0001808)1.96766562
100Deep philtrum (HP:0002002)1.96290414
101Nasal polyposis (HP:0100582)1.95697965
102Panhypogammaglobulinemia (HP:0003139)1.95533410
103Stomatitis (HP:0010280)1.94783355
104Myocardial infarction (HP:0001658)1.94095224
105Abnormality of the radial head (HP:0003995)1.93266991
106Woolly hair (HP:0002224)1.92753621
107Alopecia of scalp (HP:0002293)1.92443200
108Type 1 muscle fiber predominance (HP:0003803)1.92248544
109Wormian bones (HP:0002645)1.92024374
110Reticulocytopenia (HP:0001896)1.91740642
111Abnormality of the nasal septum (HP:0000419)1.90885434
112Supernumerary ribs (HP:0005815)1.89609873
113Squamous cell carcinoma (HP:0002860)1.89504175
114Esophageal varix (HP:0002040)1.88833312
115Congenital, generalized hypertrichosis (HP:0004540)1.87790557
116Blue irides (HP:0000635)1.84883039
117Hypoplastic labia majora (HP:0000059)1.84398217
118Anal stenosis (HP:0002025)1.83524723
119Pulmonary artery stenosis (HP:0004415)1.83233489
120Keratoconjunctivitis sicca (HP:0001097)1.82532208
121Prominent nose (HP:0000448)1.82279762
122Abnormality of the columella (HP:0009929)1.81490936
123Abnormal blistering of the skin (HP:0008066)1.80919085
124Anhidrosis (HP:0000970)1.80283333
125Supernumerary nipples (HP:0002558)1.80099293
126Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.79517252
127Arterial thrombosis (HP:0004420)1.78762549
128Craniofacial hyperostosis (HP:0004493)1.78483642
129Cheilitis (HP:0100825)1.78451669
130Flared metaphyses (HP:0003015)1.78080753
131Abnormality of the gastric mucosa (HP:0004295)1.78016767
132Asplenia (HP:0001746)1.77838028
133Recurrent bronchitis (HP:0002837)1.77600831
134Erythema (HP:0010783)1.77586935
135Mildly elevated creatine phosphokinase (HP:0008180)1.75978416
136Mediastinal lymphadenopathy (HP:0100721)1.75879182
137Emphysema (HP:0002097)1.75810012
138Sparse scalp hair (HP:0002209)1.75098335
139Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.74524704
140Generalized hypopigmentation of hair (HP:0011358)1.74068385
141Abnormality of the lacrimal duct (HP:0011481)1.72663467
142Spinal cord lesions (HP:0100561)1.72115931
143Syringomyelia (HP:0003396)1.72115931
144Supernumerary bones of the axial skeleton (HP:0009144)1.71315320
145Unilateral renal agenesis (HP:0000122)1.70983383
146Alveolar cell carcinoma (HP:0006519)1.70918352
147Thin ribs (HP:0000883)1.70827761
148White forelock (HP:0002211)1.69430651
149Nasal speech (HP:0001611)1.69429045
150Breast hypoplasia (HP:0003187)1.69364899
151Abnormality of secondary sexual hair (HP:0009888)1.69318766
152Abnormality of the axillary hair (HP:0100134)1.69318766
153Broad ribs (HP:0000885)1.69251811
154Aplasia/Hypoplasia of the spleen (HP:0010451)1.69179724
155Retinal atrophy (HP:0001105)1.69040452
156Abnormality of the renal collecting system (HP:0004742)1.68649866
157Premature loss of primary teeth (HP:0006323)1.68201604
158Coarse hair (HP:0002208)1.68182998
159Hemoptysis (HP:0002105)1.68000309
160Hypoplasia of the iris (HP:0007676)1.67578738
161Sensory axonal neuropathy (HP:0003390)1.67538485
162Gastrointestinal stroma tumor (HP:0100723)1.67191134
163Muscle fiber inclusion bodies (HP:0100299)1.66925188
164Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.66635012
165Acanthosis nigricans (HP:0000956)1.65629870
166Laryngomalacia (HP:0001601)1.63070595
167Skin ulcer (HP:0200042)1.61297587
168Thick nail (HP:0001805)1.60418533
169Ectropion (HP:0000656)1.59835674
170Rectal prolapse (HP:0002035)1.59353117
171Aplasia of the musculature (HP:0100854)1.59163138
172Vasculitis (HP:0002633)1.59125029
173Portal hypertension (HP:0001409)1.57658538

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK27.74726122
2MST1R4.00175768
3ICK3.03327416
4MAPK152.72276636
5MAP4K12.58382604
6TIE12.56504737
7TGFBR22.53554352
8MUSK2.45896289
9EPHA22.40579854
10MAP3K142.40562400
11BMPR22.39934998
12PRPF4B2.29342652
13EPHB12.23509840
14WNK42.18685682
15IRAK32.18280546
16PIM22.04744147
17STK391.88276782
18CDK121.87884348
19MAP3K101.85746608
20FGFR41.84784703
21NLK1.84496071
22EPHA31.83916808
23NEK61.79037528
24TXK1.75543492
25MKNK21.75497455
26IKBKB1.75054466
27SMG11.73357384
28STK101.67904152
29MET1.67442475
30PIM11.66147807
31BRSK21.64918371
32CHUK1.59529172
33AKT31.52644770
34CSK1.47288320
35ERN11.46834823
36MST41.46675595
37MAP3K31.44931171
38KDR1.33681317
39FGFR31.32279316
40TEC1.31228662
41GRK61.27123695
42PRKD21.26767118
43IKBKE1.25476700
44BTK1.24212600
45RPS6KB21.24165006
46TGFBR11.17443737
47CLK11.15666030
48MAPKAPK51.14905827
49LATS21.13959393
50ZAK1.12835826
51ITK1.12543271
52JAK31.10033899
53MAP2K31.09739353
54RIPK11.09169056
55HIPK21.06515645
56MAP2K21.05491734
57CDK91.04918883
58MAPK111.03623018
59TBK11.00830965
60ZAP700.99950733
61MKNK10.99009487
62TLK10.97589241
63GSK3A0.97138489
64OXSR10.96257576
65HCK0.91275343
66JAK10.90570814
67TSSK60.90126609
68MELK0.90025017
69EPHB20.88480819
70LRRK20.86548677
71MAPKAPK30.85647311
72TYK20.85230541
73TAOK30.85157116
74EEF2K0.85018137
75CDK60.84269455
76TRPM70.83104924
77MATK0.82419881
78DMPK0.81969845
79WEE10.80832178
80PTK60.80755204
81GRK10.80132719
82SIK20.80115924
83MAPK70.78677797
84BLK0.78526116
85PBK0.78145229
86DYRK1B0.77995071
87FLT30.76566343
88BRD40.76043236
89TRIB30.74901688
90MAP3K70.74392603
91BMX0.74386130
92RPS6KA50.73662226
93STK240.73338704
94SIK10.72547234
95NME20.72270148
96IRAK40.72262984
97FER0.70503586
98TTN0.69328878
99MAPK40.69087056
100MAP3K130.67100109
101RPS6KA60.66052882
102PIK3CG0.65270588
103MAP3K20.64647984
104PDPK10.64344271
105LCK0.62962313
106KIT0.62612938
107NME10.62030209
108PRKG20.61323391
109RPS6KC10.61268861
110RPS6KL10.61268861
111IRAK10.57866527
112FGFR20.57282750
113DYRK30.56634938
114MAP2K10.56340551
115JAK20.56031294
116CDK70.55905596
117CASK0.55829273
118RPS6KA40.55501069
119RPS6KA10.55405258
120PAK20.55111966
121CSF1R0.54829046
122WNK10.54570558
123YES10.54468254
124ABL10.54461371
125MAPK10.53742332
126PDGFRB0.53317437
127PRKAA20.51728272
128MAPKAPK20.51057738
129PRKD10.50681975
130MAP3K90.49019562
131RPS6KA20.48483746
132LATS10.47850792
133MTOR0.47157286
134FGFR10.46517129
135MARK20.45922449
136MAPK120.45651684
137CDK40.45327486
138EIF2AK20.44960790
139SIK30.44556830
140PTK20.44443205
141PRKAA10.43219663
142MAPK30.41974953
143STK380.39918253
144RAF10.39496140
145TAOK20.39339275
146PDK10.38078772
147MAP3K10.36365868
148MAPK80.36118561
149IRAK20.33570071

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.67254639
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.53627483
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.52331764
4Osteoclast differentiation_Homo sapiens_hsa043802.16981716
5Ovarian steroidogenesis_Homo sapiens_hsa049132.08987759
6Asthma_Homo sapiens_hsa053102.02373271
7B cell receptor signaling pathway_Homo sapiens_hsa046621.99322680
8Nitrogen metabolism_Homo sapiens_hsa009101.98420547
9Transcriptional misregulation in cancer_Homo sapiens_hsa052021.95465564
10Notch signaling pathway_Homo sapiens_hsa043301.95284839
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.83290952
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.81755732
13Acute myeloid leukemia_Homo sapiens_hsa052211.75095016
14Leishmaniasis_Homo sapiens_hsa051401.73471878
15Ribosome_Homo sapiens_hsa030101.72705045
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.72090020
17Autoimmune thyroid disease_Homo sapiens_hsa053201.71190997
18Small cell lung cancer_Homo sapiens_hsa052221.71079010
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.70440300
20Arginine biosynthesis_Homo sapiens_hsa002201.69476880
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.67470267
22Toxoplasmosis_Homo sapiens_hsa051451.66028714
23Antigen processing and presentation_Homo sapiens_hsa046121.65302365
24Measles_Homo sapiens_hsa051621.62789900
25TNF signaling pathway_Homo sapiens_hsa046681.57559410
26Allograft rejection_Homo sapiens_hsa053301.57269138
27Hematopoietic cell lineage_Homo sapiens_hsa046401.50394921
28T cell receptor signaling pathway_Homo sapiens_hsa046601.49850058
29Basal cell carcinoma_Homo sapiens_hsa052171.49706026
30ECM-receptor interaction_Homo sapiens_hsa045121.48625916
31Malaria_Homo sapiens_hsa051441.47813384
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42893643
33Adherens junction_Homo sapiens_hsa045201.42332043
34MicroRNAs in cancer_Homo sapiens_hsa052061.41762929
35Herpes simplex infection_Homo sapiens_hsa051681.39912586
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.39240109
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35049149
38mTOR signaling pathway_Homo sapiens_hsa041501.32508492
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29523669
40Systemic lupus erythematosus_Homo sapiens_hsa053221.25422801
41Focal adhesion_Homo sapiens_hsa045101.23681323
42HTLV-I infection_Homo sapiens_hsa051661.23052830
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22838739
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20306462
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17559618
46Type I diabetes mellitus_Homo sapiens_hsa049401.17506074
47Chronic myeloid leukemia_Homo sapiens_hsa052201.15111032
48Apoptosis_Homo sapiens_hsa042101.14428309
49Circadian rhythm_Homo sapiens_hsa047101.09316414
50Viral myocarditis_Homo sapiens_hsa054161.09182294
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08484840
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07717745
53Pathways in cancer_Homo sapiens_hsa052001.07590187
54Proteoglycans in cancer_Homo sapiens_hsa052051.06267919
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04040542
56Dorso-ventral axis formation_Homo sapiens_hsa043200.99421927
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99288127
58Hepatitis B_Homo sapiens_hsa051610.99139877
59Prostate cancer_Homo sapiens_hsa052150.97788976
60Influenza A_Homo sapiens_hsa051640.97386213
61Prolactin signaling pathway_Homo sapiens_hsa049170.96660385
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95592854
63Platelet activation_Homo sapiens_hsa046110.95425169
64p53 signaling pathway_Homo sapiens_hsa041150.95357845
65GnRH signaling pathway_Homo sapiens_hsa049120.91335740
66Amoebiasis_Homo sapiens_hsa051460.86921462
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.86821128
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85168120
69Hepatitis C_Homo sapiens_hsa051600.84500570
70Lysine degradation_Homo sapiens_hsa003100.81951237
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80887425
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80570986
73Insulin resistance_Homo sapiens_hsa049310.80353029
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78675027
75Wnt signaling pathway_Homo sapiens_hsa043100.78340973
76Viral carcinogenesis_Homo sapiens_hsa052030.77900715
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.77817352
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.77794537
79Hippo signaling pathway_Homo sapiens_hsa043900.77224608
80FoxO signaling pathway_Homo sapiens_hsa040680.76937610
81Choline metabolism in cancer_Homo sapiens_hsa052310.76886204
82Other glycan degradation_Homo sapiens_hsa005110.75906830
83Bladder cancer_Homo sapiens_hsa052190.75457131
84Legionellosis_Homo sapiens_hsa051340.75243096
85Non-small cell lung cancer_Homo sapiens_hsa052230.75075945
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75058571
87TGF-beta signaling pathway_Homo sapiens_hsa043500.74123962
88Inositol phosphate metabolism_Homo sapiens_hsa005620.73928048
89Renin secretion_Homo sapiens_hsa049240.72862894
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72640749
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71464562
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71135045
93Chemokine signaling pathway_Homo sapiens_hsa040620.70988390
94MAPK signaling pathway_Homo sapiens_hsa040100.69960047
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.69843036
96ErbB signaling pathway_Homo sapiens_hsa040120.69802102
97Staphylococcus aureus infection_Homo sapiens_hsa051500.67824159
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67461964
99Thyroid cancer_Homo sapiens_hsa052160.66329501
100Rheumatoid arthritis_Homo sapiens_hsa053230.65513103
101Salmonella infection_Homo sapiens_hsa051320.65199207
102Pertussis_Homo sapiens_hsa051330.65042548
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62476436
104Shigellosis_Homo sapiens_hsa051310.62465302
105Hedgehog signaling pathway_Homo sapiens_hsa043400.62348629
106Insulin signaling pathway_Homo sapiens_hsa049100.60871132
107Sphingolipid metabolism_Homo sapiens_hsa006000.60777963
108Colorectal cancer_Homo sapiens_hsa052100.60348064
109Dilated cardiomyopathy_Homo sapiens_hsa054140.60097515
110Graft-versus-host disease_Homo sapiens_hsa053320.59811145
111Caffeine metabolism_Homo sapiens_hsa002320.59452123
112Pancreatic cancer_Homo sapiens_hsa052120.58952950
113VEGF signaling pathway_Homo sapiens_hsa043700.58713068
114Epstein-Barr virus infection_Homo sapiens_hsa051690.58204667
115ABC transporters_Homo sapiens_hsa020100.57910832
116African trypanosomiasis_Homo sapiens_hsa051430.55595012
117Selenocompound metabolism_Homo sapiens_hsa004500.54613243
118Rap1 signaling pathway_Homo sapiens_hsa040150.54337399
119HIF-1 signaling pathway_Homo sapiens_hsa040660.53720365
120Complement and coagulation cascades_Homo sapiens_hsa046100.53471777
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53086051
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52792455
123Arachidonic acid metabolism_Homo sapiens_hsa005900.52287161
124Renal cell carcinoma_Homo sapiens_hsa052110.50514841
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47961220
126Tight junction_Homo sapiens_hsa045300.47340316
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46731730
128Tuberculosis_Homo sapiens_hsa051520.44495891
129Endometrial cancer_Homo sapiens_hsa052130.42288744
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42118613

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