SIK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)4.53787714
2superoxide anion generation (GO:0042554)4.36643391
3negative regulation of granulocyte differentiation (GO:0030853)4.10748732
4G-protein coupled receptor internalization (GO:0002031)3.71609452
5brown fat cell differentiation (GO:0050873)3.41466147
6white fat cell differentiation (GO:0050872)3.40994790
7acylglycerol catabolic process (GO:0046464)3.34064499
8neutral lipid catabolic process (GO:0046461)3.34064499
9negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.27716926
10import into cell (GO:0098657)3.11326396
11positive regulation of smooth muscle cell migration (GO:0014911)3.02749465
12positive regulation of heat generation (GO:0031652)2.96534318
13embryonic retina morphogenesis in camera-type eye (GO:0060059)2.94086828
14fatty acid homeostasis (GO:0055089)2.92359602
15cellular response to epinephrine stimulus (GO:0071872)2.89308561
16synaptic vesicle docking involved in exocytosis (GO:0016081)2.85458666
17low-density lipoprotein particle clearance (GO:0034383)2.84076798
18regulation of non-canonical Wnt signaling pathway (GO:2000050)2.84004526
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80567004
20negative regulation of protein autophosphorylation (GO:0031953)2.80123840
21positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.78539245
22ethanol oxidation (GO:0006069)2.77428904
23lipid storage (GO:0019915)2.76621970
24negative regulation of fatty acid transport (GO:2000192)2.72235564
25positive regulation of cellular amide metabolic process (GO:0034250)2.72171212
26protein carboxylation (GO:0018214)2.71486549
27peptidyl-glutamic acid carboxylation (GO:0017187)2.71486549
28insulin-like growth factor receptor signaling pathway (GO:0048009)2.70733249
29response to epinephrine (GO:0071871)2.70329045
30cAMP catabolic process (GO:0006198)2.67210360
31retina vasculature morphogenesis in camera-type eye (GO:0061299)2.65580355
32regulation of glycogen (starch) synthase activity (GO:2000465)2.64119033
33biotin metabolic process (GO:0006768)2.63988326
34glycerolipid catabolic process (GO:0046503)2.63045147
35plasma lipoprotein particle clearance (GO:0034381)2.59373836
36cyclic nucleotide catabolic process (GO:0009214)2.59097314
37histone H3-K36 demethylation (GO:0070544)2.57231408
38positive regulation of glucose import (GO:0046326)2.56079551
39negative regulation of lipid storage (GO:0010888)2.55665824
40superoxide metabolic process (GO:0006801)2.54616984
41complement activation, alternative pathway (GO:0006957)2.53352018
42polyol transport (GO:0015791)2.52417028
43regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.50770184
44regulation of cAMP-dependent protein kinase activity (GO:2000479)2.50656347
45regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.50467463
46mesenchymal-epithelial cell signaling (GO:0060638)2.49477844
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.48124996
48response to host immune response (GO:0052572)2.48124996
49positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.47557709
50cytoskeletal anchoring at plasma membrane (GO:0007016)2.46409336
51diacylglycerol metabolic process (GO:0046339)2.46405850
52adrenergic receptor signaling pathway (GO:0071875)2.45576782
53positive regulation of fatty acid beta-oxidation (GO:0032000)2.45253046
54regulation of cholesterol homeostasis (GO:2000188)2.45126870
55positive regulation of fatty acid oxidation (GO:0046321)2.44850458
56daunorubicin metabolic process (GO:0044597)2.43904344
57polyketide metabolic process (GO:0030638)2.43904344
58doxorubicin metabolic process (GO:0044598)2.43904344
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.43151812
60macroautophagy (GO:0016236)2.40952662
61limb bud formation (GO:0060174)2.40584054
62negative regulation of systemic arterial blood pressure (GO:0003085)2.40332321
63triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.38901147
64myelination in peripheral nervous system (GO:0022011)2.38816694
65peripheral nervous system axon ensheathment (GO:0032292)2.38816694
66histone H3-K4 trimethylation (GO:0080182)2.38474273
67positive regulation of glucose transport (GO:0010828)2.38181066
68tyrosine phosphorylation of STAT protein (GO:0007260)2.37447542
69negative regulation of gluconeogenesis (GO:0045721)2.36408489
70regulation of heat generation (GO:0031650)2.36262862
71regulation of protein activation cascade (GO:2000257)2.35516015
72regulation of complement activation (GO:0030449)2.35296932
73positive regulation of cholesterol efflux (GO:0010875)2.34267014
74activation of protein kinase A activity (GO:0034199)2.33797189
75cGMP-mediated signaling (GO:0019934)2.32939704
76glycine transport (GO:0015816)2.32816926
77regulation of pigment cell differentiation (GO:0050932)2.32458972
78protein heterotrimerization (GO:0070208)2.30154126
79positive regulation of glycolytic process (GO:0045821)2.29427603
80startle response (GO:0001964)2.28933070
81response to dietary excess (GO:0002021)2.27627050
82regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.27508727
83negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.26763010
84mesenchymal cell differentiation involved in kidney development (GO:0072161)2.26082238
85mesenchymal cell differentiation involved in renal system development (GO:2001012)2.26082238
86triglyceride homeostasis (GO:0070328)2.25959523
87acylglycerol homeostasis (GO:0055090)2.25959523
88regulation of cholesterol storage (GO:0010885)2.25908992
89mesenchymal cell differentiation (GO:0048762)2.25586051
90presynaptic membrane assembly (GO:0097105)2.25524051
91response to catecholamine (GO:0071869)2.25503709
92response to monoamine (GO:0071867)2.25503709
93response to folic acid (GO:0051593)2.24278264
94regulation of germinal center formation (GO:0002634)2.24094351
95carnitine shuttle (GO:0006853)2.24027262
96regulation of fatty acid oxidation (GO:0046320)2.23703062
97positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.23258546
98fatty acid transmembrane transport (GO:1902001)2.22841028
99ovulation from ovarian follicle (GO:0001542)2.22414233
100positive regulation of lipid storage (GO:0010884)2.22163708
101detection of molecule of bacterial origin (GO:0032490)2.21822266
102mitochondrion distribution (GO:0048311)2.21075565
103righting reflex (GO:0060013)2.20584974
104positive regulation of interleukin-1 beta secretion (GO:0050718)2.19889338
105regulation of activation of Janus kinase activity (GO:0010533)2.19261663
106retina layer formation (GO:0010842)2.19144086
107positive regulation of lipid catabolic process (GO:0050996)2.18103502
108detection of other organism (GO:0098543)2.17598611
109negative regulation of vascular permeability (GO:0043116)2.17555719
110positive regulation of CREB transcription factor activity (GO:0032793)2.17537540
111regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.16766253
112modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.16363504
113positive regulation by organism of defense response of other organism involved in symbiotic interact2.16363504
114modulation by symbiont of host immune response (GO:0052553)2.16363504
115positive regulation by symbiont of host defense response (GO:0052509)2.16363504
116modulation by symbiont of host defense response (GO:0052031)2.16363504
117modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.16363504
118detection of calcium ion (GO:0005513)2.15817977
119energy homeostasis (GO:0097009)2.15496157
120endocrine hormone secretion (GO:0060986)2.14893022
121phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.14717544
122camera-type eye morphogenesis (GO:0048593)2.14626894
123reflex (GO:0060004)2.14326084
124prostate gland growth (GO:0060736)2.13951895
125neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.13802893
126positive regulation of fatty acid metabolic process (GO:0045923)2.12909527
127negative regulation of phagocytosis (GO:0050765)2.12822348
128response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.12666286
129response to host (GO:0075136)2.12666286
130response to host defenses (GO:0052200)2.12666286
131negative regulation of protein activation cascade (GO:2000258)2.12568677
132extracellular regulation of signal transduction (GO:1900115)2.11721799
133extracellular negative regulation of signal transduction (GO:1900116)2.11721799
134carnitine transmembrane transport (GO:1902603)2.10919775
135positive regulation of glycogen biosynthetic process (GO:0045725)2.10887251
136regulation of fatty acid beta-oxidation (GO:0031998)2.10765249
137regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.10582314
138cerebral cortex radially oriented cell migration (GO:0021799)2.10517974
139peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.10158168
140cilium or flagellum-dependent cell motility (GO:0001539)2.10157317
141positive regulation of sterol transport (GO:0032373)2.09812420
142positive regulation of cholesterol transport (GO:0032376)2.09812420
143termination of G-protein coupled receptor signaling pathway (GO:0038032)2.09442280
144negative regulation of synaptic transmission, GABAergic (GO:0032229)2.09163224
145regulation of NIK/NF-kappaB signaling (GO:1901222)2.08859780
146response to lipoprotein particle (GO:0055094)2.08755194
147negative regulation of G-protein coupled receptor protein signaling pathway (GO:0045744)2.07706900
148regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.07603702
149membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.07220580
150ethanol metabolic process (GO:0006067)2.07173372
151cell communication by electrical coupling (GO:0010644)2.06385373
152negative regulation of complement activation (GO:0045916)2.06012914
153positive regulation of protein kinase C signaling (GO:0090037)2.05884012
154urea metabolic process (GO:0019627)2.05772247
155regulation of granulocyte differentiation (GO:0030852)2.05418347
156regulation of lipid catabolic process (GO:0050994)2.05026057
157cellular response to monoamine stimulus (GO:0071868)2.04951742
158cellular response to catecholamine stimulus (GO:0071870)2.04951742
159L-amino acid import (GO:0043092)2.04792838
160triglyceride catabolic process (GO:0019433)2.03933528
161cardiac myofibril assembly (GO:0055003)2.03841755
162regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.03014687
163glomerular basement membrane development (GO:0032836)2.02678791
164neuronal ion channel clustering (GO:0045161)2.02180377
165urea cycle (GO:0000050)2.01171332
166carnitine transport (GO:0015879)2.00545991
167amino-acid betaine transport (GO:0015838)2.00545991
168regulation of triglyceride biosynthetic process (GO:0010866)1.99838724
169negative regulation of lipase activity (GO:0060192)1.99301664
170fibroblast migration (GO:0010761)1.96842289
171cellular sodium ion homeostasis (GO:0006883)1.96799448
172growth hormone receptor signaling pathway (GO:0060396)1.96377371
173sodium ion export (GO:0071436)1.95510187
174cellular potassium ion homeostasis (GO:0030007)1.95011730
175negative regulation of lipid transport (GO:0032369)1.93992024
176myofibril assembly (GO:0030239)1.93691095
177glomerular filtration (GO:0003094)1.92405144
178negative regulation of Rho protein signal transduction (GO:0035024)1.91249717
179metanephric tubule development (GO:0072170)1.90865456
180metanephric nephron tubule development (GO:0072234)1.90865456
181cellular response to growth hormone stimulus (GO:0071378)1.90189812
182cell migration involved in heart development (GO:0060973)1.89367396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.02418578
2EZH2_22144423_ChIP-Seq_EOC_Human2.54669792
3* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41185543
4PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35655296
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.34503863
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.18047256
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.14954858
8SUZ12_27294783_Chip-Seq_NPCs_Mouse2.10568184
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07292967
10PCGF2_27294783_Chip-Seq_NPCs_Mouse2.05850726
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.02977776
12TRIM28_21343339_ChIP-Seq_HEK293_Human1.97663651
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95677956
14NFE2_27457419_Chip-Seq_LIVER_Mouse1.95385001
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94591504
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93666532
17* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92641877
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.83633741
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.83112913
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.81947762
21TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.80188914
22LXR_22158963_ChIP-Seq_LIVER_Mouse1.79001444
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76158531
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76016599
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74936871
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.74906769
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74804636
28EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.74754791
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.72316909
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.71905166
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70989995
32IGF1R_20145208_ChIP-Seq_DFB_Human1.70623679
33JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69171131
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69168249
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.68965633
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.68393867
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.68297560
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67646543
39P300_19829295_ChIP-Seq_ESCs_Human1.66935257
40P53_22387025_ChIP-Seq_ESCs_Mouse1.66658867
41SUZ12_18555785_Chip-Seq_ESCs_Mouse1.65793964
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.65263618
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.60610284
44SMAD4_21799915_ChIP-Seq_A2780_Human1.59056655
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.59021924
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58242270
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56465088
48STAT3_18555785_Chip-Seq_ESCs_Mouse1.55708197
49CMYC_18555785_Chip-Seq_ESCs_Mouse1.54999013
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54099747
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53907782
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53824706
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52258627
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.50811381
55TAF15_26573619_Chip-Seq_HEK293_Human1.50395624
56EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.49851531
57DROSHA_22980978_ChIP-Seq_HELA_Human1.49415915
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47946428
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47946428
60EZH2_27304074_Chip-Seq_ESCs_Mouse1.47661875
61NMYC_18555785_Chip-Seq_ESCs_Mouse1.47356853
62P300_18555785_Chip-Seq_ESCs_Mouse1.47042396
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46514414
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46212728
65STAT3_23295773_ChIP-Seq_U87_Human1.44836492
66GATA1_22025678_ChIP-Seq_K562_Human1.44679072
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.44189310
68OCT4_18555785_Chip-Seq_ESCs_Mouse1.42799515
69ER_23166858_ChIP-Seq_MCF-7_Human1.41902255
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41604639
71* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40832639
72PU1_27457419_Chip-Seq_LIVER_Mouse1.40653576
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39809719
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39686162
75FOXA2_19822575_ChIP-Seq_HepG2_Human1.38852095
76CLOCK_20551151_ChIP-Seq_293T_Human1.37735689
77RUNX1_27457419_Chip-Seq_LIVER_Mouse1.36211892
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33979059
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.32940941
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32379592
81TCF4_23295773_ChIP-Seq_U87_Human1.32139767
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31981786
83TP53_18474530_ChIP-ChIP_U2OS_Human1.31868574
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31720659
85ESRRB_18555785_Chip-Seq_ESCs_Mouse1.31603243
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31295416
87ZFX_18555785_Chip-Seq_ESCs_Mouse1.30977713
88AR_21572438_ChIP-Seq_LNCaP_Human1.30964739
89IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30356734
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.30052641
91KLF4_18555785_Chip-Seq_ESCs_Mouse1.29901408
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29294862
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.29169551
94* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28998833
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.28324487
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.28002223
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27811123
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26935844
99* KDM2B_26808549_Chip-Seq_K562_Human1.25954526
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.25657293
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.25657293
102MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25344628
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25291642
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24210542
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24169883
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.23883397
107SMAD1_18555785_Chip-Seq_ESCs_Mouse1.23346434
108AR_25329375_ChIP-Seq_VCAP_Human1.23035653
109KDM2B_26808549_Chip-Seq_REH_Human1.22748381
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21453388
111TAL1_26923725_Chip-Seq_HPCs_Mouse1.21438279
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20418019
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19662210
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19522721
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.19504680
116* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19478571
117* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19478571
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.19377233
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18989204
120SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18970802
121TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18355735
122AHR_22903824_ChIP-Seq_MCF-7_Human1.18228497
123NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18212691
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17910952
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.17711925
126RUNX2_22187159_ChIP-Seq_PCA_Human1.17442378
127* ISL1_27105846_Chip-Seq_CPCs_Mouse1.16913069
128FUS_26573619_Chip-Seq_HEK293_Human1.16294896
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15504138
130EZH2_27294783_Chip-Seq_ESCs_Mouse1.15329965
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14696955
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14428170
133STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14110324
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.13557091
135NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13395095
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12316534
137KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12144390
138NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10721043
139TP53_16413492_ChIP-PET_HCT116_Human1.10698886
140VDR_24787735_ChIP-Seq_THP-1_Human1.09204589
141GATA2_21666600_ChIP-Seq_HMVEC_Human1.08551571
142DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07997506
143RING1B_27294783_Chip-Seq_NPCs_Mouse1.06536170
144ESR1_20079471_ChIP-ChIP_T-47D_Human1.05810041
145PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05487162
146CJUN_26792858_Chip-Seq_BT549_Human1.04893908
147RING1B_27294783_Chip-Seq_ESCs_Mouse1.03880027
148RARB_27405468_Chip-Seq_BRAIN_Mouse1.02623122
149YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00062595
150NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96367506
151NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96367506
152* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96260387
153PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95638138
154TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94282721
155ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94072101
156AR_19668381_ChIP-Seq_PC3_Human0.93528824
157TP53_23651856_ChIP-Seq_MEFs_Mouse0.90082659
158TCF4_18268006_ChIP-ChIP_LS174T_Human0.89770853
159STAT6_21828071_ChIP-Seq_BEAS2B_Human0.88692873
160CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88180973
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87743058
162TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87710453
163PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87538440
164SMAD3_21741376_ChIP-Seq_HESCs_Human0.85629112
165TP53_20018659_ChIP-ChIP_R1E_Mouse0.85297584

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.78902393
2MP0000569_abnormal_digit_pigmentation3.80269992
3MP0002876_abnormal_thyroid_physiology3.43518980
4MP0005666_abnormal_adipose_tissue3.29247697
5MP0001188_hyperpigmentation3.23081902
6MP0005645_abnormal_hypothalamus_physiol2.86769084
7MP0002102_abnormal_ear_morphology2.60828681
8MP0000751_myopathy2.43901852
9MP0003705_abnormal_hypodermis_morpholog2.42856871
10MP0004130_abnormal_muscle_cell2.30011015
11MP0004185_abnormal_adipocyte_glucose2.28049343
12MP0003045_fibrosis2.16694175
13MP0005375_adipose_tissue_phenotype2.14440812
14MP0008438_abnormal_cutaneous_collagen2.13262201
15MP0010368_abnormal_lymphatic_system2.12647908
16MP0004272_abnormal_basement_membrane2.06306217
17MP0010329_abnormal_lipoprotein_level2.01753237
18MP0005409_darkened_coat_color1.97177290
19MP0006138_congestive_heart_failure1.93635365
20MP0002971_abnormal_brown_adipose1.88667324
21MP0003724_increased_susceptibility_to1.87041413
22MP0003787_abnormal_imprinting1.81071181
23MP0000566_synostosis1.80923358
24MP0005171_absent_coat_pigmentation1.76941198
25MP0001501_abnormal_sleep_pattern1.73559118
26MP0009115_abnormal_fat_cell1.70747527
27MP0005334_abnormal_fat_pad1.69547225
28MP0005646_abnormal_pituitary_gland1.68659634
29MP0001958_emphysema1.68516460
30MP0006292_abnormal_olfactory_placode1.67925713
31MP0003136_yellow_coat_color1.66112998
32MP0003868_abnormal_feces_composition1.64994047
33MP0000015_abnormal_ear_pigmentation1.59693389
34MP0002909_abnormal_adrenal_gland1.57099705
35MP0001486_abnormal_startle_reflex1.56399846
36MP0000383_abnormal_hair_follicle1.53502009
37MP0005365_abnormal_bile_salt1.52882898
38MP0003283_abnormal_digestive_organ1.52125027
39MP0002277_abnormal_respiratory_mucosa1.51967724
40MP0004742_abnormal_vestibular_system1.47214707
41MP0001986_abnormal_taste_sensitivity1.45868482
42MP0004381_abnormal_hair_follicle1.43525759
43MP0002139_abnormal_hepatobiliary_system1.42480519
44MP0003950_abnormal_plasma_membrane1.42244112
45MP0004087_abnormal_muscle_fiber1.34435148
46MP0002638_abnormal_pupillary_reflex1.32489487
47MP0002118_abnormal_lipid_homeostasis1.32440694
48MP0005535_abnormal_body_temperature1.32017992
49MP0003195_calcinosis1.31838595
50MP0005174_abnormal_tail_pigmentation1.29887657
51MP0002009_preneoplasia1.29312039
52MP0004215_abnormal_myocardial_fiber1.28698318
53MP0001661_extended_life_span1.28015134
54MP0003279_aneurysm1.27653295
55MP0003091_abnormal_cell_migration1.26189933
56MP0004484_altered_response_of1.26083496
57MP0005379_endocrine/exocrine_gland_phen1.24883252
58MP0004084_abnormal_cardiac_muscle1.24270004
59MP0004036_abnormal_muscle_relaxation1.22853008
60MP0003879_abnormal_hair_cell1.22624319
61MP0000427_abnormal_hair_cycle1.20972450
62MP0004859_abnormal_synaptic_plasticity1.20962306
63MP0005423_abnormal_somatic_nervous1.17004378
64MP0005595_abnormal_vascular_smooth1.16434615
65MP0003828_pulmonary_edema1.14475824
66MP0002998_abnormal_bone_remodeling1.13312745
67MP0002295_abnormal_pulmonary_circulatio1.09069456
68MP0000003_abnormal_adipose_tissue1.07645947
69MP0001835_abnormal_antigen_presentation1.05911374
70MP0005167_abnormal_blood-brain_barrier1.05097473
71MP0002735_abnormal_chemical_nociception1.04949731
72MP0003329_amyloid_beta_deposits1.04684025
73MP0005620_abnormal_muscle_contractility1.04292546
74MP0002168_other_aberrant_phenotype1.03162774
75MP0009046_muscle_twitch1.02478793
76MP0005551_abnormal_eye_electrophysiolog1.02347946
77MP0004270_analgesia1.02079366
78MP0009764_decreased_sensitivity_to1.01655422
79MP0000759_abnormal_skeletal_muscle1.01302270
80MP0001790_abnormal_immune_system1.00977660
81MP0005387_immune_system_phenotype1.00977660
82MP0000747_muscle_weakness0.99217512
83MP0000026_abnormal_inner_ear0.98685533
84MP0002254_reproductive_system_inflammat0.96931419
85MP0003690_abnormal_glial_cell0.95713748
86MP0000579_abnormal_nail_morphology0.95600328
87MP0002896_abnormal_bone_mineralization0.95589681
88MP0002006_tumorigenesis0.95094471
89MP0005451_abnormal_body_composition0.95036341
90MP0003566_abnormal_cell_adhesion0.94506803
91MP0005647_abnormal_sex_gland0.93397690
92MP0002078_abnormal_glucose_homeostasis0.93243400
93MP0001177_atelectasis0.92632451
94MP0000767_abnormal_smooth_muscle0.90918478
95MP0002166_altered_tumor_susceptibility0.89777718
96MP0010630_abnormal_cardiac_muscle0.89639957
97MP0002419_abnormal_innate_immunity0.88735075
98MP0003959_abnormal_lean_body0.88730787
99MP0003941_abnormal_skin_development0.87471395
100MP0001299_abnormal_eye_distance/0.87031476
101MP0005253_abnormal_eye_physiology0.86865038
102MP0005448_abnormal_energy_balance0.86471215
103MP0010386_abnormal_urinary_bladder0.85833012
104MP0009697_abnormal_copulation0.85739218
105MP0002837_dystrophic_cardiac_calcinosis0.85540090
106MP0001502_abnormal_circadian_rhythm0.85515834
107MP0005385_cardiovascular_system_phenoty0.84676413
108MP0001544_abnormal_cardiovascular_syste0.84676413
109MP0001346_abnormal_lacrimal_gland0.84308690
110MP0002249_abnormal_larynx_morphology0.84280664
111MP0004858_abnormal_nervous_system0.84267472
112MP0002148_abnormal_hypersensitivity_rea0.84108897
113MP0002108_abnormal_muscle_morphology0.83024448
114MP0005076_abnormal_cell_differentiation0.82877578
115MP0000733_abnormal_muscle_development0.82413764
116MP0005275_abnormal_skin_tensile0.82304268
117MP0001963_abnormal_hearing_physiology0.81430883
118MP0002060_abnormal_skin_morphology0.80608904
119MP0009840_abnormal_foam_cell0.80300397
120MP0004510_myositis0.79684251
121MP0009384_cardiac_valve_regurgitation0.78890036
122MP0002972_abnormal_cardiac_muscle0.77456636
123MP0000681_abnormal_thyroid_gland0.77370625
124MP0002063_abnormal_learning/memory/cond0.77293950
125MP0003011_delayed_dark_adaptation0.77260029
126MP0005452_abnormal_adipose_tissue0.76682165
127MP0003948_abnormal_gas_homeostasis0.76400297
128MP0004085_abnormal_heartbeat0.75494889
129MP0005369_muscle_phenotype0.74892264
130MP0003635_abnormal_synaptic_transmissio0.74716223
131MP0004782_abnormal_surfactant_physiolog0.73852584
132MP0005257_abnormal_intraocular_pressure0.72569832
133MP0009785_altered_susceptibility_to0.72415544
134MP0005503_abnormal_tendon_morphology0.71842665
135MP0005085_abnormal_gallbladder_physiolo0.71726741
136MP0000013_abnormal_adipose_tissue0.71523027
137MP0005623_abnormal_meninges_morphology0.71173177
138MP0005330_cardiomyopathy0.70924723
139MP0008260_abnormal_autophagy0.70763533
140MP0002067_abnormal_sensory_capabilities0.70155081
141MP0005671_abnormal_response_to0.69808562
142MP0002064_seizures0.69800539
143MP0002928_abnormal_bile_duct0.69387402
144MP0002970_abnormal_white_adipose0.69026876
145MP0002128_abnormal_blood_circulation0.68501579
146MP0000749_muscle_degeneration0.68063971
147MP0000778_abnormal_nervous_system0.67816159
148MP0003953_abnormal_hormone_level0.67355297
149MP0003942_abnormal_urinary_system0.66854445
150MP0008875_abnormal_xenobiotic_pharmacok0.66674734
151MP0009780_abnormal_chondrocyte_physiolo0.64676127
152MP0010678_abnormal_skin_adnexa0.63651773
153MP0008775_abnormal_heart_ventricle0.62179675
154MP0009745_abnormal_behavioral_response0.61457481
155MP0001879_abnormal_lymphatic_vessel0.56861256
156MP0008004_abnormal_stomach_pH0.56460232
157MP0006276_abnormal_autonomic_nervous0.54979124
158MP0004134_abnormal_chest_morphology0.54675130
159MP0000371_diluted_coat_color0.54429676
160MP0004147_increased_porphyrin_level0.53768285

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.10811100
2Chromsome breakage (HP:0040012)4.47285151
3Prostate neoplasm (HP:0100787)3.95997524
4Duplicated collecting system (HP:0000081)3.83194058
5Febrile seizures (HP:0002373)3.77549251
6Abnormality of the renal collecting system (HP:0004742)3.54826057
7Protrusio acetabuli (HP:0003179)3.51201363
8Complement deficiency (HP:0004431)3.49835764
9Upper limb muscle weakness (HP:0003484)3.18511986
10Oligomenorrhea (HP:0000876)3.01622977
11Thyroid-stimulating hormone excess (HP:0002925)3.00910897
12Abnormality of incisor morphology (HP:0011063)2.95436271
13Renal cortical cysts (HP:0000803)2.94638416
14Mesomelia (HP:0003027)2.92456882
15Aplasia cutis congenita (HP:0001057)2.91354410
16Broad metatarsal (HP:0001783)2.91097593
17Abnormality of the nasal septum (HP:0000419)2.86249725
18Abnormality of complement system (HP:0005339)2.79670703
19Aortic aneurysm (HP:0004942)2.78933673
20Septo-optic dysplasia (HP:0100842)2.77319430
21Turricephaly (HP:0000262)2.75774751
22Mitral stenosis (HP:0001718)2.73205892
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.73090906
24Absent/shortened dynein arms (HP:0200106)2.73090906
25Shallow orbits (HP:0000586)2.72300220
26Alveolar cell carcinoma (HP:0006519)2.70831529
27Increased variability in muscle fiber diameter (HP:0003557)2.70543727
28Chronic hepatic failure (HP:0100626)2.68828720
29Congenital sensorineural hearing impairment (HP:0008527)2.68409886
30Bronchomalacia (HP:0002780)2.66905701
31Overgrowth (HP:0001548)2.64809728
32Congenital stationary night blindness (HP:0007642)2.63048098
33Abnormal ciliary motility (HP:0012262)2.58848512
34Vascular tortuosity (HP:0004948)2.54438657
35Insulin-resistant diabetes mellitus (HP:0000831)2.53914523
36Tubulointerstitial nephritis (HP:0001970)2.53842169
37Coronal craniosynostosis (HP:0004440)2.53061360
38Oligodactyly (hands) (HP:0001180)2.52159331
39Difficulty running (HP:0009046)2.49101610
40Pigmentary retinal degeneration (HP:0001146)2.47969145
41Hemorrhage of the eye (HP:0011885)2.46647381
42Cerebral aneurysm (HP:0004944)2.43735291
43Neoplasm of the tracheobronchial system (HP:0100552)2.43155523
44Ulnar bowing (HP:0003031)2.41554963
45Dysmetric saccades (HP:0000641)2.38431308
46Arterial tortuosity (HP:0005116)2.37616467
47Hyperlipoproteinemia (HP:0010980)2.37027805
48Obstructive sleep apnea (HP:0002870)2.36507865
49Decreased central vision (HP:0007663)2.36415689
50Acanthosis nigricans (HP:0000956)2.29028844
51Hyporeflexia of lower limbs (HP:0002600)2.28232755
52Abnormality of monocarboxylic acid metabolism (HP:0010996)2.24758117
53Abnormality of the renal cortex (HP:0011035)2.24486934
54Fair hair (HP:0002286)2.24159524
55Aplasia of the phalanges of the hand (HP:0009802)2.23750553
56Aplasia involving bones of the extremities (HP:0009825)2.23750553
57Aplasia involving bones of the upper limbs (HP:0009823)2.23750553
58Increased connective tissue (HP:0009025)2.22876285
59Joint hemorrhage (HP:0005261)2.21475875
60White forelock (HP:0002211)2.21352821
61Skin nodule (HP:0200036)2.20899662
62Xanthomatosis (HP:0000991)2.19362140
63Long foot (HP:0001833)2.18942188
64Deep venous thrombosis (HP:0002625)2.17237977
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16464161
66Abnormality of DNA repair (HP:0003254)2.16012552
67Abnormality of the ischium (HP:0003174)2.15075112
68Optic neuritis (HP:0100653)2.13597264
69Retrobulbar optic neuritis (HP:0100654)2.13597264
70Type 1 muscle fiber predominance (HP:0003803)2.13453491
71Hypoplasia of the iris (HP:0007676)2.12270379
72Spinal rigidity (HP:0003306)2.09563123
73Submucous cleft hard palate (HP:0000176)2.08364076
74Clubbing of toes (HP:0100760)2.07570546
75Abnormality of skeletal muscle fiber size (HP:0012084)2.06047955
76Hypertriglyceridemia (HP:0002155)2.06044216
77Wormian bones (HP:0002645)2.05922695
78Atrioventricular block (HP:0001678)2.03489902
79Abnormality of the fingertips (HP:0001211)2.02063394
80Recurrent cutaneous fungal infections (HP:0011370)2.01252735
81Chronic mucocutaneous candidiasis (HP:0002728)2.01252735
82Premature rupture of membranes (HP:0001788)1.99414653
83Pulmonary artery stenosis (HP:0004415)1.99264068
84Mitral valve prolapse (HP:0001634)1.99041934
85Renovascular hypertension (HP:0100817)1.98650445
86Focal motor seizures (HP:0011153)1.98511339
87Generalized hypopigmentation of hair (HP:0011358)1.98440045
88Duplication of thumb phalanx (HP:0009942)1.98425996
89Abnormality of the renal medulla (HP:0100957)1.97854555
90Bladder diverticulum (HP:0000015)1.97791958
91Glomerulonephritis (HP:0000099)1.97716183
92Patchy hypopigmentation of hair (HP:0011365)1.96908764
93Abnormal respiratory motile cilium physiology (HP:0012261)1.96410139
94Optic nerve hypoplasia (HP:0000609)1.96311457
95Conical tooth (HP:0000698)1.96086347
96Aortic dissection (HP:0002647)1.95908413
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.94764485
98Vertebral arch anomaly (HP:0008438)1.92857036
99Attenuation of retinal blood vessels (HP:0007843)1.92713825
100Bundle branch block (HP:0011710)1.92144199
101Asymmetric septal hypertrophy (HP:0001670)1.91130731
102Nephronophthisis (HP:0000090)1.91025010
103Protruding tongue (HP:0010808)1.90453286
104Muscle fiber splitting (HP:0003555)1.89652027
105Abnormality of the common coagulation pathway (HP:0010990)1.89144230
106Action tremor (HP:0002345)1.88614146
107Neonatal hypoglycemia (HP:0001998)1.88186184
108Congenital hepatic fibrosis (HP:0002612)1.88101695
109Hypothermia (HP:0002045)1.86795423
110Wide anterior fontanel (HP:0000260)1.86364135
111Increased corneal curvature (HP:0100692)1.85642543
112Keratoconus (HP:0000563)1.85642543
113Blue irides (HP:0000635)1.84822243
114Bell-shaped thorax (HP:0001591)1.84696946
115Hypercholesterolemia (HP:0003124)1.84477628
116Hypoalphalipoproteinemia (HP:0003233)1.84380223
117Distal lower limb amyotrophy (HP:0008944)1.84282511
118Abnormal atrioventricular conduction (HP:0005150)1.84021308
119Insulin resistance (HP:0000855)1.83960855
120Lip pit (HP:0100267)1.83596568
121Chronic diarrhea (HP:0002028)1.82908911
122Ectropion (HP:0000656)1.82489526
123Frequent falls (HP:0002359)1.82232424
124Absent speech (HP:0001344)1.82129224
125Absent frontal sinuses (HP:0002688)1.81642106
126Striae distensae (HP:0001065)1.81475996
127Cerebral inclusion bodies (HP:0100314)1.81259162
128Bradycardia (HP:0001662)1.80901205
129Atrial fibrillation (HP:0005110)1.80877258
130Mildly elevated creatine phosphokinase (HP:0008180)1.79814461
131Limited hip movement (HP:0008800)1.79798249
132Aneurysm (HP:0002617)1.79169024
133Nephritis (HP:0000123)1.79063759
134Exercise-induced myalgia (HP:0003738)1.77427538
135Prolonged partial thromboplastin time (HP:0003645)1.76491033
136Postaxial foot polydactyly (HP:0001830)1.76191992
137Abnormality of the carotid arteries (HP:0005344)1.75902147
138Back pain (HP:0003418)1.75818409
139Heart block (HP:0012722)1.74805724
140Gingivitis (HP:0000230)1.73904612
141Macroorchidism (HP:0000053)1.73025639
142Myotonia (HP:0002486)1.71856151
143Hypercortisolism (HP:0001578)1.71577813
144Craniofacial hyperostosis (HP:0004493)1.70904687
145Tracheomalacia (HP:0002779)1.70056968
146Anal stenosis (HP:0002025)1.69619998
147Neurofibrillary tangles (HP:0002185)1.69455423
148Epidermoid cyst (HP:0200040)1.68385541
149Distal lower limb muscle weakness (HP:0009053)1.67327997
150Exotropia (HP:0000577)1.67158003
151Hyperacusis (HP:0010780)1.66840551
152Abnormality of the prostate (HP:0008775)1.66711945
153Nasolacrimal duct obstruction (HP:0000579)1.66189015
154Abnormality of the intrinsic pathway (HP:0010989)1.66098199
155Neonatal short-limb short stature (HP:0008921)1.65914730
156Fibular hypoplasia (HP:0003038)1.65869927
157Median cleft lip (HP:0000161)1.65738924
158Corneal dystrophy (HP:0001131)1.65507629
159Lower limb amyotrophy (HP:0007210)1.65275105
160Ectopic kidney (HP:0000086)1.64433505
161Thin bony cortex (HP:0002753)1.63532724
162Cervical subluxation (HP:0003308)1.62133203
163Cranial hyperostosis (HP:0004437)1.61804834
164Accelerated skeletal maturation (HP:0005616)1.61602998
165Xerostomia (HP:0000217)1.61387454
166Hypoplastic ischia (HP:0003175)1.60539084
167Prominent supraorbital ridges (HP:0000336)1.60131851
168Hyperkalemia (HP:0002153)1.59716905
169Long nose (HP:0003189)1.59537825
170Infantile muscular hypotonia (HP:0008947)1.59260571
171Abnormal respiratory epithelium morphology (HP:0012253)1.58701722
172Abnormal respiratory motile cilium morphology (HP:0005938)1.58701722
173Hyperextensible skin (HP:0000974)1.58458652
174Abnormality of primary teeth (HP:0006481)1.57938207
175Advanced eruption of teeth (HP:0006288)1.57905866
176Follicular hyperkeratosis (HP:0007502)1.57597014
177Scapular winging (HP:0003691)1.57592063
178Dyschromatopsia (HP:0007641)1.57422280
179Primary atrial arrhythmia (HP:0001692)1.56737236
180Persistence of primary teeth (HP:0006335)1.56258414
181Abnormality of salivation (HP:0100755)1.55965122
182Abnormal delayed hypersensitivity skin test (HP:0002963)1.55692235
183Abnormality of chromosome stability (HP:0003220)1.55599958
184Prolonged bleeding time (HP:0003010)1.55139391
185Truncal ataxia (HP:0002078)1.53626570
186Drooling (HP:0002307)1.53253956
187Excessive salivation (HP:0003781)1.53253956
188Cardiovascular calcification (HP:0011915)1.53207208
189Lymphangioma (HP:0100764)1.52758429
190Prolonged QT interval (HP:0001657)1.52006575
191Soft skin (HP:0000977)1.51736568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D3.73659333
2CASK3.53988349
3INSRR3.37433556
4CAMK1G2.99325293
5RIPK12.77986705
6TRIB32.70523856
7EIF2AK22.62470504
8IRAK32.48011344
9EEF2K2.34079996
10TNIK2.32872229
11MAP3K142.27504693
12PDGFRA2.15503362
13LATS22.14509657
14TXK1.99118017
15ICK1.97307402
16ZAK1.91479614
17PRPF4B1.83405176
18MARK11.76264107
19GRK11.68388411
20SIK11.67710835
21NUAK11.67027330
22IRAK41.65325932
23DDR21.59969188
24ERN11.56718835
25SIK31.53709696
26PRKAA21.52079645
27PDGFRB1.46392354
28NTRK11.45777509
29YES11.43349693
30JAK11.41989369
31FRK1.41690136
32NEK91.41080873
33TTN1.36674587
34PKN11.32081066
35NTRK31.29267558
36TNK21.27579756
37SGK21.25748666
38MAPK151.18958435
39MTOR1.18042673
40IRAK21.17492405
41IRAK11.17107376
42MAP2K71.16538413
43MAP3K91.14184554
44PINK11.14160113
45CDK31.13309250
46RET1.12989610
47PIK3CA1.12090699
48CDK91.10952357
49BRD41.09778153
50MYLK1.09570820
51ADRBK21.09216875
52FGFR41.08870612
53RIPK41.08304192
54MET1.06231158
55MKNK21.06150693
56IKBKE1.04152183
57PTK21.01597164
58TEC1.01151332
59PHKG11.00343913
60PHKG21.00343913
61LATS10.98573416
62NEK60.98217005
63TGFBR20.97841064
64MAPK70.97663572
65IKBKB0.95628226
66PDPK10.95256100
67SIK20.93400097
68MAPK130.92817484
69STK380.92638522
70PRKD30.92038969
71CDC42BPA0.90600692
72DMPK0.89309886
73PNCK0.87930131
74SGK10.87043526
75BMPR20.86522694
76JAK30.85521884
77MAP2K40.84608804
78CDK120.83303371
79MAP3K130.82013417
80PAK20.81396492
81TYRO30.81234564
82FGFR30.80158722
83PRKCE0.79782030
84MAP3K20.79374833
85BCR0.78923092
86PIK3CG0.78652183
87MAP3K60.78067313
88CHUK0.76437703
89TRPM70.76430170
90CAMK10.76391170
91MST1R0.76267078
92MUSK0.75465312
93PKN20.75437219
94STK390.75300434
95GRK70.74847721
96SGK2230.74811676
97SGK4940.74811676
98FGFR20.74801207
99SGK30.74756294
100RPS6KA20.74365411
101MAP2K10.71938454
102HIPK20.71682405
103EPHB20.71492434
104TIE10.70609903
105MAPK40.67449489
106BMPR1B0.67253701
107CDK50.67027593
108KSR20.66248010
109TAOK30.65236996
110UHMK10.64867395
111PRKAA10.64299460
112NTRK20.64134477
113CAMKK10.63533238
114STK30.62118056
115PAK60.61845331
116LMTK20.60114923
117CLK10.59143972
118MAPK110.58744802
119WNK40.58515240
120DAPK20.57084502
121MAPKAPK30.56920074
122OBSCN0.56452795
123MAPK100.56153279
124STK160.56003728
125WNK10.55549559
126KIT0.55455840
127PRKD10.54867752
128AKT30.54627453
129PDK10.54535971
130CSF1R0.54280527
131RPS6KA30.53645787
132NLK0.53001871
133STK38L0.51285239
134FER0.50883058
135PRKD20.50727546
136HCK0.50567133
137EPHA30.49556174
138EPHB10.49462139
139MARK20.49059389
140PRKG10.49051117
141EPHA40.48106067
142PDK20.47383593
143PRKCQ0.47058530
144ROCK10.47027581
145PRKACG0.46169849
146MAP3K70.44673889
147MAPK120.44656880
148CAMK40.43538284
149IGF1R0.43328909
150LYN0.41313069
151INSR0.41092940
152ABL10.38913121
153PRKCH0.37969353
154MAP3K40.37344730
155LCK0.36320352
156CSK0.35875318

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.10157873
2Fatty acid biosynthesis_Homo sapiens_hsa000612.83471536
3Autoimmune thyroid disease_Homo sapiens_hsa053201.85303382
4Propanoate metabolism_Homo sapiens_hsa006401.82371500
5Nicotine addiction_Homo sapiens_hsa050331.78625635
6Phenylalanine metabolism_Homo sapiens_hsa003601.74832611
7Complement and coagulation cascades_Homo sapiens_hsa046101.69480227
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.67048305
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65692748
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.64791623
11Fatty acid degradation_Homo sapiens_hsa000711.64375546
12Histidine metabolism_Homo sapiens_hsa003401.62487127
13PPAR signaling pathway_Homo sapiens_hsa033201.62237051
14Morphine addiction_Homo sapiens_hsa050321.61762736
15Phototransduction_Homo sapiens_hsa047441.60107943
16Bile secretion_Homo sapiens_hsa049761.54368894
17Glycerolipid metabolism_Homo sapiens_hsa005611.43727125
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.40438178
19Arginine biosynthesis_Homo sapiens_hsa002201.37802356
20Graft-versus-host disease_Homo sapiens_hsa053321.34381232
21ABC transporters_Homo sapiens_hsa020101.28225842
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28007711
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24935965
24Allograft rejection_Homo sapiens_hsa053301.24001444
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22892805
26Hematopoietic cell lineage_Homo sapiens_hsa046401.21772889
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.19571372
28Type II diabetes mellitus_Homo sapiens_hsa049301.19564030
29Fatty acid metabolism_Homo sapiens_hsa012121.18657066
30Focal adhesion_Homo sapiens_hsa045101.18581729
31Renin secretion_Homo sapiens_hsa049241.17205128
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17033784
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16650584
34Taste transduction_Homo sapiens_hsa047421.16297516
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15947611
36Tyrosine metabolism_Homo sapiens_hsa003501.14831449
37ECM-receptor interaction_Homo sapiens_hsa045121.14693947
38Fanconi anemia pathway_Homo sapiens_hsa034601.13267714
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13120471
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09714224
41Calcium signaling pathway_Homo sapiens_hsa040201.08600347
42TNF signaling pathway_Homo sapiens_hsa046681.08518350
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07913415
44Insulin secretion_Homo sapiens_hsa049111.06612240
45Osteoclast differentiation_Homo sapiens_hsa043801.05920015
46beta-Alanine metabolism_Homo sapiens_hsa004101.04888496
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03795098
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.02438353
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01484795
50Malaria_Homo sapiens_hsa051441.00409462
51Glutamatergic synapse_Homo sapiens_hsa047241.00229017
52cAMP signaling pathway_Homo sapiens_hsa040240.99737805
53Butanoate metabolism_Homo sapiens_hsa006500.99197377
54Measles_Homo sapiens_hsa051620.99185978
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98330469
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97934198
57Salivary secretion_Homo sapiens_hsa049700.97796941
58Ovarian steroidogenesis_Homo sapiens_hsa049130.97611445
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97361006
60Staphylococcus aureus infection_Homo sapiens_hsa051500.96556020
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96093829
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.95624869
63Vitamin B6 metabolism_Homo sapiens_hsa007500.94952621
64Gastric acid secretion_Homo sapiens_hsa049710.94893513
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94590586
66Tryptophan metabolism_Homo sapiens_hsa003800.94211517
67Lysine degradation_Homo sapiens_hsa003100.93917397
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93914383
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.93803143
70Retinol metabolism_Homo sapiens_hsa008300.92807537
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92475816
72Dorso-ventral axis formation_Homo sapiens_hsa043200.92469652
73Rheumatoid arthritis_Homo sapiens_hsa053230.91340585
74Insulin signaling pathway_Homo sapiens_hsa049100.90733197
75Inositol phosphate metabolism_Homo sapiens_hsa005620.89031695
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87802006
77Circadian entrainment_Homo sapiens_hsa047130.87595943
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87253141
79Long-term potentiation_Homo sapiens_hsa047200.86541975
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85197222
81Chemokine signaling pathway_Homo sapiens_hsa040620.84907364
82Vitamin digestion and absorption_Homo sapiens_hsa049770.84297960
83Cocaine addiction_Homo sapiens_hsa050300.83898945
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82189611
85AMPK signaling pathway_Homo sapiens_hsa041520.82075154
86African trypanosomiasis_Homo sapiens_hsa051430.81683951
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81682861
88Olfactory transduction_Homo sapiens_hsa047400.81400129
89Prion diseases_Homo sapiens_hsa050200.81397140
90Asthma_Homo sapiens_hsa053100.80607183
91GnRH signaling pathway_Homo sapiens_hsa049120.79003457
92Estrogen signaling pathway_Homo sapiens_hsa049150.78808514
93Sphingolipid metabolism_Homo sapiens_hsa006000.78347504
94Thyroid hormone synthesis_Homo sapiens_hsa049180.77687676
95Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77475085
96* Glucagon signaling pathway_Homo sapiens_hsa049220.75911875
97Serotonergic synapse_Homo sapiens_hsa047260.75619386
98Arachidonic acid metabolism_Homo sapiens_hsa005900.75572446
99Protein digestion and absorption_Homo sapiens_hsa049740.74977457
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74812832
101Amphetamine addiction_Homo sapiens_hsa050310.74266117
102Oxytocin signaling pathway_Homo sapiens_hsa049210.73999334
103Adherens junction_Homo sapiens_hsa045200.73734296
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73693459
105Fat digestion and absorption_Homo sapiens_hsa049750.73416064
106Leishmaniasis_Homo sapiens_hsa051400.73102553
107Axon guidance_Homo sapiens_hsa043600.72337467
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71466069
109Melanogenesis_Homo sapiens_hsa049160.70936221
110Small cell lung cancer_Homo sapiens_hsa052220.70306010
111Ether lipid metabolism_Homo sapiens_hsa005650.70105023
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69879132
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68028578
114Fatty acid elongation_Homo sapiens_hsa000620.67597272
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67547945
116Primary immunodeficiency_Homo sapiens_hsa053400.65946872
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.64563760
118Pyruvate metabolism_Homo sapiens_hsa006200.64511834
119Caffeine metabolism_Homo sapiens_hsa002320.64420215
120Melanoma_Homo sapiens_hsa052180.64242600
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.64224220
122Dilated cardiomyopathy_Homo sapiens_hsa054140.62338340
123Gap junction_Homo sapiens_hsa045400.62171682
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61886696
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61731938
126Chemical carcinogenesis_Homo sapiens_hsa052040.61388934
127Circadian rhythm_Homo sapiens_hsa047100.61362755
128Amoebiasis_Homo sapiens_hsa051460.61108757
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60808892
130Cholinergic synapse_Homo sapiens_hsa047250.59969160
131Ras signaling pathway_Homo sapiens_hsa040140.59800992
132Glioma_Homo sapiens_hsa052140.59411224
133Pancreatic secretion_Homo sapiens_hsa049720.57877975
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57419363
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57303691
136Dopaminergic synapse_Homo sapiens_hsa047280.56288433
137Non-homologous end-joining_Homo sapiens_hsa034500.56104374
138Choline metabolism in cancer_Homo sapiens_hsa052310.55979154
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.55776162
140mTOR signaling pathway_Homo sapiens_hsa041500.55496256
141Tight junction_Homo sapiens_hsa045300.55307227
142Basal cell carcinoma_Homo sapiens_hsa052170.55298462
143Long-term depression_Homo sapiens_hsa047300.55025030
144Notch signaling pathway_Homo sapiens_hsa043300.54528711
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.54467648
146Proteoglycans in cancer_Homo sapiens_hsa052050.54358660
147Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53902603
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52924021
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52823500
150Hepatitis C_Homo sapiens_hsa051600.52611965
151Influenza A_Homo sapiens_hsa051640.52573614
152Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52545256
153Insulin resistance_Homo sapiens_hsa049310.52423364
154AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51980700
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.51718010
156ErbB signaling pathway_Homo sapiens_hsa040120.51149390
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.50732740
158Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50074338
159Toxoplasmosis_Homo sapiens_hsa051450.49710898
160GABAergic synapse_Homo sapiens_hsa047270.49676095

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