SIK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.77350642
2synaptic vesicle maturation (GO:0016188)4.74018548
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.47249793
4negative regulation of cell killing (GO:0031342)4.47249793
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.30189913
6positive regulation of gamma-delta T cell activation (GO:0046645)4.13627782
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08316159
8sodium ion export (GO:0071436)4.00884477
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.93845950
10negative regulation of erythrocyte differentiation (GO:0045647)3.69886300
11cellular potassium ion homeostasis (GO:0030007)3.61456600
12vocalization behavior (GO:0071625)3.52395671
13regulation of synaptic vesicle exocytosis (GO:2000300)3.45057616
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.43671317
15glutamate secretion (GO:0014047)3.43644556
16gamma-aminobutyric acid transport (GO:0015812)3.43340635
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38111065
18regulation of synapse structural plasticity (GO:0051823)3.36330324
19regulation of B cell receptor signaling pathway (GO:0050855)3.34742567
20synaptic vesicle exocytosis (GO:0016079)3.34369665
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.34034312
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31640992
23regulation of gamma-delta T cell activation (GO:0046643)3.30549414
24regulation of glutamate receptor signaling pathway (GO:1900449)3.29552049
25regulation of ARF protein signal transduction (GO:0032012)3.29410012
26activation of protein kinase A activity (GO:0034199)3.27651884
27potassium ion import (GO:0010107)3.27390453
28macrophage activation involved in immune response (GO:0002281)3.27158727
29positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.23181851
30neurotransmitter secretion (GO:0007269)3.22920183
31layer formation in cerebral cortex (GO:0021819)3.22891967
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.16549298
33regulation of neuronal synaptic plasticity (GO:0048168)3.15551240
34glycine transport (GO:0015816)3.14798358
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.14216711
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.14184092
37neuromuscular process controlling posture (GO:0050884)3.06167817
38exploration behavior (GO:0035640)3.06096559
39germinal center formation (GO:0002467)3.04800962
40regulation of gamma-delta T cell differentiation (GO:0045586)3.02805906
41regulation of synaptic vesicle transport (GO:1902803)3.01797314
42cell communication by electrical coupling (GO:0010644)3.01549177
43neuromuscular process controlling balance (GO:0050885)3.01224181
44regulation of T-helper 2 cell differentiation (GO:0045628)2.98477068
45L-amino acid import (GO:0043092)2.98133227
46cytoskeletal anchoring at plasma membrane (GO:0007016)2.98007465
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.96779131
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96328790
49dendritic spine morphogenesis (GO:0060997)2.93177860
50leukocyte aggregation (GO:0070486)2.91805998
51long-term memory (GO:0007616)2.89653574
52negative regulation of lymphocyte mediated immunity (GO:0002707)2.86320980
53modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.84210977
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.84210977
55positive regulation by organism of defense response of other organism involved in symbiotic interact2.84210977
56modulation by symbiont of host immune response (GO:0052553)2.84210977
57positive regulation by symbiont of host defense response (GO:0052509)2.84210977
58modulation by symbiont of host defense response (GO:0052031)2.84210977
59neuronal action potential propagation (GO:0019227)2.81830566
60prepulse inhibition (GO:0060134)2.81657203
61response to muramyl dipeptide (GO:0032495)2.81531894
62cerebellar Purkinje cell differentiation (GO:0021702)2.80922068
63response to peptidoglycan (GO:0032494)2.80162956
64positive regulation of cellular amide metabolic process (GO:0034250)2.78279804
65antigen processing and presentation of endogenous antigen (GO:0019883)2.78157058
66negative regulation of T cell mediated immunity (GO:0002710)2.75624111
67negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.75436000
68dendrite morphogenesis (GO:0048813)2.75028907
69regulation of clathrin-mediated endocytosis (GO:2000369)2.72234331
70nerve growth factor signaling pathway (GO:0038180)2.72010053
71detection of molecule of bacterial origin (GO:0032490)2.71355494
72negative regulation of interleukin-12 production (GO:0032695)2.70827205
73regulation of ARF GTPase activity (GO:0032312)2.70145139
74detection of other organism (GO:0098543)2.69445559
75potassium ion homeostasis (GO:0055075)2.69289858
76B cell receptor signaling pathway (GO:0050853)2.69220390
77antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69011707
78response to interleukin-15 (GO:0070672)2.67371457
79neuronal ion channel clustering (GO:0045161)2.67224771
80cellular extravasation (GO:0045123)2.66742869
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.65873729
82synaptic transmission, glutamatergic (GO:0035249)2.64833538
83neurotransmitter-gated ion channel clustering (GO:0072578)2.62979429
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62374897
85cellular sodium ion homeostasis (GO:0006883)2.61945318
86negative regulation of leukocyte mediated immunity (GO:0002704)2.61924349
87neurotransmitter transport (GO:0006836)2.61666601
88peptidyl-tyrosine autophosphorylation (GO:0038083)2.61207951
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61176962
90protein localization to synapse (GO:0035418)2.59759603
91glutamate receptor signaling pathway (GO:0007215)2.59407487
92regulation of excitatory postsynaptic membrane potential (GO:0060079)2.58912063
93histone H3-K36 demethylation (GO:0070544)2.58679937
94transmission of nerve impulse (GO:0019226)2.57259674
95vesicle transport along microtubule (GO:0047496)2.56312126
96negative regulation of type 2 immune response (GO:0002829)2.55968881
97regulation of dendritic spine morphogenesis (GO:0061001)2.55491187
98positive thymic T cell selection (GO:0045059)2.55041198
99cerebellar Purkinje cell layer development (GO:0021680)2.54958083
100regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.54248842
101establishment of nucleus localization (GO:0040023)2.54248126
102negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54088400
103neuron-neuron synaptic transmission (GO:0007270)2.53322006
104negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.51224329
105regulation of synaptic plasticity (GO:0048167)2.50917412
106auditory behavior (GO:0031223)2.50766128
107macrophage activation (GO:0042116)2.50401112
108regulation of neurotransmitter levels (GO:0001505)2.49950001
109positive regulation of membrane potential (GO:0045838)2.49681589
110cell communication involved in cardiac conduction (GO:0086065)2.48919854
111mating behavior (GO:0007617)2.48797756
112cerebellar granule cell differentiation (GO:0021707)2.47780282
113detection of bacterium (GO:0016045)2.47325515
114negative regulation of T-helper cell differentiation (GO:0045623)2.45341188
115negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.45341188
116central nervous system myelination (GO:0022010)2.44867165
117axon ensheathment in central nervous system (GO:0032291)2.44867165
118protein localization to endosome (GO:0036010)2.44342285
119proline transport (GO:0015824)2.43139338
120detection of external biotic stimulus (GO:0098581)2.41952743
121regulation of postsynaptic membrane potential (GO:0060078)2.41682164
122cellular response to ethanol (GO:0071361)2.41271553
123positive regulation of Rap GTPase activity (GO:0032854)2.40600018
124negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.40567433
125negative regulation of toll-like receptor signaling pathway (GO:0034122)2.40328939
126membrane repolarization (GO:0086009)2.39365793
127regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.39301909
128dicarboxylic acid biosynthetic process (GO:0043650)2.39203386
129membrane depolarization during action potential (GO:0086010)2.37540245
130long-term synaptic potentiation (GO:0060291)2.37523410
131regulation of beta-amyloid formation (GO:1902003)2.37385074
132suckling behavior (GO:0001967)2.36959767
133adult walking behavior (GO:0007628)2.36703811
134regulation of voltage-gated calcium channel activity (GO:1901385)2.36480951
135cellular response to interleukin-15 (GO:0071350)2.35819093
136regulation of Rap GTPase activity (GO:0032317)2.35455127
137chemosensory behavior (GO:0007635)2.35013366
138positive T cell selection (GO:0043368)2.34358283
139response to auditory stimulus (GO:0010996)2.34229139
140regulation of interleukin-12 biosynthetic process (GO:0045075)2.33371426
141regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33332055
142positive regulation of potassium ion transmembrane transport (GO:1901381)2.32959656
143regulation of calcium ion transmembrane transport (GO:1903169)2.32491088
144regulation of calcium ion transmembrane transporter activity (GO:1901019)2.32491088
145membrane tubulation (GO:0097320)2.32163175
146positive regulation of potassium ion transport (GO:0043268)2.31670530
147organelle transport along microtubule (GO:0072384)2.30495011
148negative thymic T cell selection (GO:0045060)2.30240262
149cellular response to epinephrine stimulus (GO:0071872)2.29941908
150microglial cell activation (GO:0001774)2.29693196
151neuron cell-cell adhesion (GO:0007158)2.29616958
152amino acid import (GO:0043090)2.29232736
153neuromuscular process (GO:0050905)2.28997459
154negative regulation of potassium ion transmembrane transport (GO:1901380)2.28657740
155regulation of regulated secretory pathway (GO:1903305)2.28553261
156regulation of leukocyte degranulation (GO:0043300)2.27431845
157signal complex assembly (GO:0007172)2.24938622
158lipopolysaccharide-mediated signaling pathway (GO:0031663)2.22632862
159regulation of myeloid leukocyte mediated immunity (GO:0002886)2.22566624
160mannose metabolic process (GO:0006013)2.22254584
161neutrophil activation involved in immune response (GO:0002283)2.20391786
162negative T cell selection (GO:0043383)2.19993627
163regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.19758011
164myeloid cell activation involved in immune response (GO:0002275)2.18968144
165neutrophil mediated immunity (GO:0002446)2.17374083
166detection of biotic stimulus (GO:0009595)2.16157294
167regulation of mast cell degranulation (GO:0043304)2.15329343
168defense response to protozoan (GO:0042832)2.14243415
169regulation of interferon-beta biosynthetic process (GO:0045357)2.13433248
170regulation of macrophage cytokine production (GO:0010935)2.12981915
171regulation of type 2 immune response (GO:0002828)2.11085396
172activated T cell proliferation (GO:0050798)2.09372518
173negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.09232180
174negative regulation of inclusion body assembly (GO:0090084)2.08778608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.65329253
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.96537624
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.81632498
4DROSHA_22980978_ChIP-Seq_HELA_Human2.61057418
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.57457811
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.29257385
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27199586
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21269620
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16606555
10RUNX_20019798_ChIP-Seq_JUKART_Human2.15545358
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14075075
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.06522370
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04636443
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04636443
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03591129
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98351419
17* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.89578618
18TCF7_22412390_ChIP-Seq_EML_Mouse1.87167701
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85003381
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.84955177
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82189635
22* IRF8_27001747_Chip-Seq_BMDM_Mouse1.80658043
23REST_21632747_ChIP-Seq_MESCs_Mouse1.79549692
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79228182
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.78803428
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78794727
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75693236
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71971381
29KDM2B_26808549_Chip-Seq_K562_Human1.71842935
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70136682
31GBX2_23144817_ChIP-Seq_PC3_Human1.69766255
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.69450528
33SPI1_23127762_ChIP-Seq_K562_Human1.69256385
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69091135
35SCL_19346495_ChIP-Seq_HPC-7_Human1.66828110
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.65186102
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64760682
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.63740163
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.58848693
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57374200
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56652187
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.56382083
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56124523
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.55362552
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.55359626
46VDR_24763502_ChIP-Seq_THP-1_Human1.53894707
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53421091
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.51436037
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51223481
50GATA1_22025678_ChIP-Seq_K562_Human1.51010853
51EZH2_27304074_Chip-Seq_ESCs_Mouse1.49751127
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47023923
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44848238
54AR_21572438_ChIP-Seq_LNCaP_Human1.44815783
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44711811
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.44542119
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43994470
58* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.42839916
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42555477
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39351472
61VDR_24787735_ChIP-Seq_THP-1_Human1.38276138
62KDM2B_26808549_Chip-Seq_DND41_Human1.38049964
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36630906
64VDR_21846776_ChIP-Seq_THP-1_Human1.36473717
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36213297
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36003814
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.33604741
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31205602
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31106336
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30391896
71MYC_22102868_ChIP-Seq_BL_Human1.30291341
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.30155959
73MAF_26560356_Chip-Seq_TH1_Human1.29757207
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27847648
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24257712
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23601539
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.22298646
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21231805
79ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20702105
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19759094
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.18883550
82FOXA2_19822575_ChIP-Seq_HepG2_Human1.18013394
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17750504
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17374048
85AR_19668381_ChIP-Seq_PC3_Human1.16398094
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.15465542
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13861350
88AHR_22903824_ChIP-Seq_MCF-7_Human1.13451494
89LXR_22292898_ChIP-Seq_THP-1_Human1.13390318
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.13192229
91GATA2_19941826_ChIP-Seq_K562_Human1.11732133
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11426044
93EP300_21415370_ChIP-Seq_HL-1_Mouse1.11243192
94UTX_26944678_Chip-Seq_JUKART_Human1.10543419
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10395182
96MYB_26560356_Chip-Seq_TH2_Human1.10136819
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09088514
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.08150917
99SOX2_21211035_ChIP-Seq_LN229_Gbm1.07000623
100CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06775529
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04863999
102* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04792700
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04536416
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03077504
105RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02470567
106* SMAD4_21799915_ChIP-Seq_A2780_Human1.02136160
107* LXR_22158963_ChIP-Seq_LIVER_Mouse1.01969284
108* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01938022
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01631871
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01488631
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01164823
112GATA1_19941826_ChIP-Seq_K562_Human1.00782547
113SMAD4_21741376_ChIP-Seq_HESCs_Human1.00116484
114* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00018353
115STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99927738
116ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99218395
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.99024552
118TP53_16413492_ChIP-PET_HCT116_Human0.98336906
119RXR_22108803_ChIP-Seq_LS180_Human0.97084169
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96526766
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.96331663
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.96119908
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.94797799
124* GATA3_27048872_Chip-Seq_THYMUS_Human0.94672885
125GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93680753
126CREB1_26743006_Chip-Seq_LNCaP_Human0.93639809
127* KLF4_19829295_ChIP-Seq_ESCs_Human0.92941009
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92571463
129STAT3_23295773_ChIP-Seq_U87_Human0.92395230
130CTCF_27219007_Chip-Seq_Bcells_Human0.92193684
131* TET1_21490601_ChIP-Seq_MESCs_Mouse0.92036013
132ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91052386
133STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90748972
134TBX20_22328084_ChIP-Seq_HEART_Mouse0.89839136
135TBX20_22080862_ChIP-Seq_HEART_Mouse0.89839136
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89480713
137SMC4_20622854_ChIP-Seq_HELA_Human0.88859088
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88614596
139MYB_26560356_Chip-Seq_TH1_Human0.87983643
140MAF_26560356_Chip-Seq_TH2_Human0.87693956
141NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87459187
142STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87015287
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.86768299
144RXR_22158963_ChIP-Seq_LIVER_Mouse0.86181885
145* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86044445
146* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84944580
147PU_27001747_Chip-Seq_BMDM_Mouse0.83961332
148STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83599564
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83461451
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82158564
151MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80287422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.67786075
2MP0002822_catalepsy3.49107656
3MP0003635_abnormal_synaptic_transmissio3.38109707
4MP0003436_decreased_susceptibility_to3.01399155
5MP0004270_analgesia2.91840524
6MP0003724_increased_susceptibility_to2.87998821
7MP0003880_abnormal_central_pattern2.83329437
8MP0002064_seizures2.70796899
9MP0009745_abnormal_behavioral_response2.69285050
10MP0009046_muscle_twitch2.59057699
11MP0002063_abnormal_learning/memory/cond2.53015811
12MP0003329_amyloid_beta_deposits2.41813290
13MP0001835_abnormal_antigen_presentation2.34616763
14MP0009780_abnormal_chondrocyte_physiolo2.29308317
15MP0002272_abnormal_nervous_system2.13400495
16MP0008961_abnormal_basal_metabolism2.13084772
17MP0002909_abnormal_adrenal_gland2.12015529
18MP0004885_abnormal_endolymph2.09900721
19MP0001486_abnormal_startle_reflex2.07316991
20MP0003763_abnormal_thymus_physiology2.06126608
21MP0005000_abnormal_immune_tolerance2.06040020
22MP0005423_abnormal_somatic_nervous2.05353256
23MP0002572_abnormal_emotion/affect_behav2.00845863
24MP0000751_myopathy1.99470005
25MP0001501_abnormal_sleep_pattern1.99215486
26MP0008569_lethality_at_weaning1.98701873
27MP0001800_abnormal_humoral_immune1.97823542
28MP0003690_abnormal_glial_cell1.97775350
29MP0002419_abnormal_innate_immunity1.97509126
30MP0001790_abnormal_immune_system1.92294494
31MP0005387_immune_system_phenotype1.92294494
32MP0000920_abnormal_myelination1.86623336
33MP0005025_abnormal_response_to1.83120224
34MP0003283_abnormal_digestive_organ1.77849641
35MP0009278_abnormal_bone_marrow1.76039740
36MP0002723_abnormal_immune_serum1.72013634
37MP0000685_abnormal_immune_system1.71059896
38MP0004947_skin_inflammation1.69878029
39MP0005671_abnormal_response_to1.67517075
40MP0002420_abnormal_adaptive_immunity1.62366344
41MP0009785_altered_susceptibility_to1.61772360
42MP0002837_dystrophic_cardiac_calcinosis1.58571778
43MP0001819_abnormal_immune_cell1.58532099
44MP0001440_abnormal_grooming_behavior1.57525820
45MP0003183_abnormal_peptide_metabolism1.57176047
46MP0004510_myositis1.54917687
47MP0006082_CNS_inflammation1.54854367
48MP0003633_abnormal_nervous_system1.54769662
49MP0002452_abnormal_antigen_presenting1.54447457
50MP0004858_abnormal_nervous_system1.52715063
51MP0002734_abnormal_mechanical_nocicepti1.50025568
52MP0003656_abnormal_erythrocyte_physiolo1.49302303
53MP0005167_abnormal_blood-brain_barrier1.49150313
54MP0003191_abnormal_cellular_cholesterol1.48852460
55MP0004130_abnormal_muscle_cell1.46898216
56MP0001533_abnormal_skeleton_physiology1.46260080
57MP0000604_amyloidosis1.43622899
58MP0005623_abnormal_meninges_morphology1.42656557
59MP0002405_respiratory_system_inflammati1.40310564
60MP0004924_abnormal_behavior1.39274670
61MP0005386_behavior/neurological_phenoty1.39274670
62MP0008260_abnormal_autophagy1.38906996
63MP0004036_abnormal_muscle_relaxation1.35325683
64MP0003828_pulmonary_edema1.34474301
65MP0002148_abnormal_hypersensitivity_rea1.33301637
66MP0004811_abnormal_neuron_physiology1.33237442
67MP0003300_gastrointestinal_ulcer1.32372227
68MP0002398_abnormal_bone_marrow1.31188904
69MP0002998_abnormal_bone_remodeling1.30279912
70MP0003075_altered_response_to1.28917006
71MP0003631_nervous_system_phenotype1.28406628
72MP0002067_abnormal_sensory_capabilities1.27980330
73MP0000747_muscle_weakness1.27538392
74MP0004084_abnormal_cardiac_muscle1.27094064
75MP0005451_abnormal_body_composition1.26989403
76MP0000013_abnormal_adipose_tissue1.26511137
77MP0000716_abnormal_immune_system1.25784170
78MP0005409_darkened_coat_color1.25685306
79MP0001968_abnormal_touch/_nociception1.25317858
80MP0000955_abnormal_spinal_cord1.24059228
81MP0004145_abnormal_muscle_electrophysio1.21751175
82MP0003045_fibrosis1.20469470
83MP0005464_abnormal_platelet_physiology1.19567877
84MP0001851_eye_inflammation1.19541518
85MP0001545_abnormal_hematopoietic_system1.18994682
86MP0005397_hematopoietic_system_phenotyp1.18994682
87MP0002066_abnormal_motor_capabilities/c1.18529134
88MP0003634_abnormal_glial_cell1.18508993
89MP0008004_abnormal_stomach_pH1.18194547
90MP0008874_decreased_physiological_sensi1.17114461
91MP0004085_abnormal_heartbeat1.16553232
92MP0000003_abnormal_adipose_tissue1.15728687
93MP0005058_abnormal_lysosome_morphology1.15553171
94MP0001970_abnormal_pain_threshold1.14543457
95MP0002733_abnormal_thermal_nociception1.13708213
96MP0004215_abnormal_myocardial_fiber1.12717920
97MP0004233_abnormal_muscle_weight1.12654687
98MP0003091_abnormal_cell_migration1.09665462
99MP0002332_abnormal_exercise_endurance1.08741347
100MP0003632_abnormal_nervous_system1.08516672
101MP0010155_abnormal_intestine_physiology1.08313348
102MP0002557_abnormal_social/conspecific_i1.07498477
103MP0005310_abnormal_salivary_gland1.07416870
104MP0005166_decreased_susceptibility_to1.07154698
105MP0002882_abnormal_neuron_morphology1.06863419
106MP0004087_abnormal_muscle_fiber1.06670237
107MP0005646_abnormal_pituitary_gland1.04464012
108MP0003137_abnormal_impulse_conducting1.02903379
109MP0000778_abnormal_nervous_system1.01603153
110MP0005535_abnormal_body_temperature1.01589858
111MP0004043_abnormal_pH_regulation1.01579869
112MP0001502_abnormal_circadian_rhythm1.00512581
113MP0009840_abnormal_foam_cell1.00429151
114MP0002229_neurodegeneration1.00197990
115MP0001299_abnormal_eye_distance/1.00032431
116MP0001845_abnormal_inflammatory_respons0.99594621
117MP0003866_abnormal_defecation0.98795507
118MP0003646_muscle_fatigue0.95897899
119MP0004142_abnormal_muscle_tone0.94842544
120MP0000703_abnormal_thymus_morphology0.94167081
121MP0002090_abnormal_vision0.93940219
122MP0005076_abnormal_cell_differentiation0.92864263
123MP0002722_abnormal_immune_system0.91443679
124MP0005375_adipose_tissue_phenotype0.91049466
125MP0010234_abnormal_vibrissa_follicle0.90699281
126MP0003303_peritoneal_inflammation0.90459766
127MP0003705_abnormal_hypodermis_morpholog0.89705746
128MP0003172_abnormal_lysosome_physiology0.89305123
129MP0000689_abnormal_spleen_morphology0.88838142
130MP0008775_abnormal_heart_ventricle0.88673148
131MP0009764_decreased_sensitivity_to0.88601086
132MP0004381_abnormal_hair_follicle0.88380414
133MP0002184_abnormal_innervation0.87470229
134MP0005330_cardiomyopathy0.86881759
135MP0002269_muscular_atrophy0.85483275
136MP0003122_maternal_imprinting0.85372888
137MP0002429_abnormal_blood_cell0.84717155
138MP0002152_abnormal_brain_morphology0.83003338
139MP0004808_abnormal_hematopoietic_stem0.82943288
140MP0004484_altered_response_of0.82595946
141MP0000569_abnormal_digit_pigmentation0.81519125
142MP0004185_abnormal_adipocyte_glucose0.78092584
143MP0005620_abnormal_muscle_contractility0.77362989
144MP0002069_abnormal_eating/drinking_beha0.77055859
145MP0001177_atelectasis0.76380275
146MP0003252_abnormal_bile_duct0.75778917
147MP0003879_abnormal_hair_cell0.75561621
148MP0002139_abnormal_hepatobiliary_system0.73686635
149MP0005551_abnormal_eye_electrophysiolog0.72782858
150MP0008469_abnormal_protein_level0.72505364
151MP0002234_abnormal_pharynx_morphology0.70075018
152MP0005187_abnormal_penis_morphology0.70028094
153MP0003787_abnormal_imprinting0.68916298
154MP0001348_abnormal_lacrimal_gland0.68319605
155MP0002118_abnormal_lipid_homeostasis0.67816894
156MP0003453_abnormal_keratinocyte_physiol0.67815942
157MP0008872_abnormal_physiological_respon0.67068444
158MP0005365_abnormal_bile_salt0.66783600

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.72487272
2Focal motor seizures (HP:0011153)4.13145165
3Focal seizures (HP:0007359)3.78254342
4Eczematoid dermatitis (HP:0000976)3.74539888
5Obstructive sleep apnea (HP:0002870)3.70376665
6Action tremor (HP:0002345)3.65968705
7Optic neuritis (HP:0100653)3.61501160
8Retrobulbar optic neuritis (HP:0100654)3.61501160
9Orchitis (HP:0100796)3.56037523
10Myositis (HP:0100614)3.55447364
11Visual hallucinations (HP:0002367)3.51898673
12Supranuclear gaze palsy (HP:0000605)3.45980855
13Recurrent bacterial skin infections (HP:0005406)3.23510549
14Neurofibrillary tangles (HP:0002185)3.21269356
15Cerebral inclusion bodies (HP:0100314)3.14303446
16Dysmetric saccades (HP:0000641)3.09735969
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.04883953
18Dysmetria (HP:0001310)3.01319527
19Recurrent abscess formation (HP:0002722)2.98888497
20Dysdiadochokinesis (HP:0002075)2.93343786
21Postural instability (HP:0002172)2.92762874
22Slow saccadic eye movements (HP:0000514)2.89878397
23Impaired social interactions (HP:0000735)2.89614788
24Abnormal social behavior (HP:0012433)2.89614788
25Ankle clonus (HP:0011448)2.87582253
26Intention tremor (HP:0002080)2.79756763
27Abnormality of macrophages (HP:0004311)2.78963586
28Depression (HP:0000716)2.76788572
29Macroorchidism (HP:0000053)2.76261243
30Progressive cerebellar ataxia (HP:0002073)2.73837404
31Genetic anticipation (HP:0003743)2.70847528
32Poor eye contact (HP:0000817)2.65208183
33Mediastinal lymphadenopathy (HP:0100721)2.64828950
34Exercise-induced myalgia (HP:0003738)2.64368959
35Stomatitis (HP:0010280)2.62842100
36Impaired vibration sensation in the lower limbs (HP:0002166)2.61257589
37Hemiplegia (HP:0002301)2.61187564
38Spastic gait (HP:0002064)2.60390168
39Recurrent gram-negative bacterial infections (HP:0005420)2.58979389
40Urinary bladder sphincter dysfunction (HP:0002839)2.58272893
41Abnormality of the fingertips (HP:0001211)2.57805226
42Bundle branch block (HP:0011710)2.57273432
43Keratoconjunctivitis sicca (HP:0001097)2.56276695
44Ventricular fibrillation (HP:0001663)2.54346786
45Gastrointestinal infarctions (HP:0005244)2.52727474
46Epileptic encephalopathy (HP:0200134)2.52000709
47Abnormality of the lower motor neuron (HP:0002366)2.50108607
48Generalized tonic-clonic seizures (HP:0002069)2.44849622
49T lymphocytopenia (HP:0005403)2.44493287
50Torticollis (HP:0000473)2.44104807
51Urinary urgency (HP:0000012)2.42592133
52Distal upper limb amyotrophy (HP:0007149)2.42125288
53Upper limb amyotrophy (HP:0009129)2.42125288
54Anxiety (HP:0000739)2.41505695
55Absence seizures (HP:0002121)2.39885435
56Hyporeflexia of lower limbs (HP:0002600)2.38603376
57Megalencephaly (HP:0001355)2.36646319
58Spontaneous hematomas (HP:0007420)2.33970104
59Atonic seizures (HP:0010819)2.33862955
60Scanning speech (HP:0002168)2.32520416
61Meningitis (HP:0001287)2.32087738
62Dialeptic seizures (HP:0011146)2.30982563
63Truncal ataxia (HP:0002078)2.30630677
64Termporal pattern (HP:0011008)2.30477948
65Insidious onset (HP:0003587)2.30477948
66Recurrent skin infections (HP:0001581)2.29380486
67Difficulty running (HP:0009046)2.29373940
68Turricephaly (HP:0000262)2.29073762
69Recurrent fungal infections (HP:0002841)2.28518789
70Vasculitis (HP:0002633)2.27845341
71Sudden death (HP:0001699)2.25978145
72Amyloidosis (HP:0011034)2.25904391
73Keratoconjunctivitis (HP:0001096)2.24728847
74Gingivitis (HP:0000230)2.24664725
75Gaze-evoked nystagmus (HP:0000640)2.24364829
76Increased IgE level (HP:0003212)2.22683804
77Broad-based gait (HP:0002136)2.21602887
78Cellulitis (HP:0100658)2.20838944
79Elevated erythrocyte sedimentation rate (HP:0003565)2.20759167
80Pulmonary infiltrates (HP:0002113)2.20225370
81Resting tremor (HP:0002322)2.18234213
82Insomnia (HP:0100785)2.17968498
83Lower limb amyotrophy (HP:0007210)2.16525757
84Prolonged QT interval (HP:0001657)2.16074417
85Abnormality of T cell number (HP:0011839)2.15108873
86Neoplasm of the heart (HP:0100544)2.14885806
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.13745744
88Abnormal eating behavior (HP:0100738)2.13199750
89Abnormality of the corticospinal tract (HP:0002492)2.12745583
90Neuronal loss in central nervous system (HP:0002529)2.12121478
91Onion bulb formation (HP:0003383)2.07854368
92Colitis (HP:0002583)2.07326200
93Broad metatarsal (HP:0001783)2.07222196
94Focal dystonia (HP:0004373)2.06623054
95Rapidly progressive (HP:0003678)2.03429072
96Lower limb muscle weakness (HP:0007340)2.02714164
97Pulmonary embolism (HP:0002204)2.01684853
98Chronic mucocutaneous candidiasis (HP:0002728)2.01297776
99Recurrent cutaneous fungal infections (HP:0011370)2.01297776
100Abnormality of saccadic eye movements (HP:0000570)2.00730408
101Prolonged bleeding time (HP:0003010)2.00522281
102Status epilepticus (HP:0002133)1.99551549
103Episodic fever (HP:0001954)1.99504748
104Inflammation of the large intestine (HP:0002037)1.98301650
105Increased variability in muscle fiber diameter (HP:0003557)1.97043737
106Papilledema (HP:0001085)1.96870244
107Impaired smooth pursuit (HP:0007772)1.96410707
108Bronchomalacia (HP:0002780)1.95989203
109Gastrointestinal inflammation (HP:0004386)1.95639372
110Craniofacial dystonia (HP:0012179)1.95604252
111Gingival bleeding (HP:0000225)1.95539953
112Dysostosis multiplex (HP:0000943)1.94547657
113Postural tremor (HP:0002174)1.94335310
114Abnormality of binocular vision (HP:0011514)1.92430819
115Diplopia (HP:0000651)1.92430819
116Abnormality of the Achilles tendon (HP:0005109)1.92154726
117Vertigo (HP:0002321)1.91799500
118Achilles tendon contracture (HP:0001771)1.91251295
119Bradykinesia (HP:0002067)1.90518284
120Arterial thrombosis (HP:0004420)1.89586183
121Recurrent viral infections (HP:0004429)1.88632290
122Hemoptysis (HP:0002105)1.88599553
123Encephalitis (HP:0002383)1.87978885
124Hyperventilation (HP:0002883)1.87164477
125Spastic tetraparesis (HP:0001285)1.87059984
126Chronic obstructive pulmonary disease (HP:0006510)1.86968278
127Obstructive lung disease (HP:0006536)1.86968278
128Atrioventricular block (HP:0001678)1.86884286
129Clonus (HP:0002169)1.85031045
130Acne (HP:0001061)1.85025210
131Hemiparesis (HP:0001269)1.83829917
132Syncope (HP:0001279)1.83013756
133Abnormality of ocular smooth pursuit (HP:0000617)1.81592587
134Annular pancreas (HP:0001734)1.81486729
135Heart block (HP:0012722)1.80215985
136Chest pain (HP:0100749)1.79873760
137Deep venous thrombosis (HP:0002625)1.79826383
138Drooling (HP:0002307)1.78876743
139Excessive salivation (HP:0003781)1.78876743
140Pointed chin (HP:0000307)1.77525383
141Muscle fiber splitting (HP:0003555)1.77121692
142Decreased motor nerve conduction velocity (HP:0003431)1.76079870
143Hammertoe (HP:0001765)1.76022880
144Cerebral aneurysm (HP:0004944)1.75596272
145Abnormal EKG (HP:0003115)1.75301362
146Rigidity (HP:0002063)1.75186131
147Stereotypic behavior (HP:0000733)1.75007579
148Increased circulating renin level (HP:0000848)1.74754598
149Epistaxis (HP:0000421)1.74410090
150Impaired vibratory sensation (HP:0002495)1.73644807
151Febrile seizures (HP:0002373)1.73034661
152Abnormality of the periventricular white matter (HP:0002518)1.71958429
153Hypsarrhythmia (HP:0002521)1.71819481
154Peripheral hypomyelination (HP:0007182)1.71444500
155EEG with generalized epileptiform discharges (HP:0011198)1.71436590
156Increased CSF protein (HP:0002922)1.70752552
157Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70377019
158Abnormality of polysaccharide metabolism (HP:0011012)1.70377019
159Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70377019
160Mucopolysacchariduria (HP:0008155)1.68597752
161Urinary glycosaminoglycan excretion (HP:0003541)1.68597752
162Fatigue (HP:0012378)1.68362073
163Memory impairment (HP:0002354)1.68271770
164Osteomyelitis (HP:0002754)1.66561427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.00615624
2MAP3K92.79200742
3NTRK32.73135853
4PRKD32.58773975
5PAK62.17859331
6KSR22.08003228
7RIPK12.00040824
8MAP4K11.95562174
9TRIB31.92717713
10NTRK11.90821586
11ICK1.87397713
12MAP3K41.86353228
13NTRK21.75800663
14CAMK1G1.72317749
15TYRO31.67934559
16MAP2K31.67709422
17DAPK21.67403773
18TYK21.65571640
19TAOK11.62835507
20CAMKK11.57648250
21WNK11.55187671
22MAP3K131.51789385
23PRKCH1.48978821
24BLK1.46034894
25CSK1.37277840
26DMPK1.37120494
27PHKG21.34714859
28PHKG11.34714859
29EPHB11.33664768
30MINK11.32348718
31SIK21.31439425
32STK381.30204668
33MAP3K71.27290990
34ZAP701.26307017
35MAP2K41.25183347
36BMX1.24714415
37MAP3K141.23943551
38ALK1.22047734
39TXK1.21953948
40CDK51.21272778
41UHMK11.20318447
42PNCK1.20206717
43SIK11.19463668
44FGFR31.15508743
45TAOK31.15301416
46STK391.15177623
47IRAK41.14937053
48MAP3K31.10952348
49MARK21.09990997
50IKBKE1.09390399
51MAP3K111.09233946
52SYK1.08170820
53SGK2231.07021550
54SGK4941.07021550
55MAPK121.06595533
56FES1.06277720
57MAP3K21.06260570
58LMTK21.06258306
59CAMK1D1.03879819
60MAP3K11.03740244
61RET1.03050720
62WNK41.01685533
63FGFR21.00372437
64SGK31.00320783
65PDGFRA1.00001936
66PAK30.99263858
67PDPK10.99068607
68MARK10.97562127
69HCK0.95852157
70OXSR10.95334678
71KSR10.91788148
72BRD40.91239018
73PDK10.89892990
74FGFR40.89729356
75PKN20.89655604
76TAOK20.88657747
77BMPR20.86492544
78JAK30.85962844
79PRPF4B0.85910938
80GRK60.85141246
81BTK0.85099622
82PTK2B0.84942149
83CDK120.81876389
84* STK110.80487741
85RIPK40.79571199
86FGR0.79150676
87TBK10.78675552
88MAPK70.78523391
89CAMK10.77832054
90PRKD10.76086663
91CDC42BPA0.75681819
92NLK0.75064880
93SGK10.72397965
94MARK30.72029460
95CAMK40.69818726
96CDK190.69507022
97PTK60.69310140
98PRKD20.68819172
99TTN0.68593307
100IRAK20.68529869
101PDGFRB0.68362399
102JAK10.67318410
103CAMK2A0.65995319
104INSRR0.65724530
105ITK0.65514517
106PINK10.65228949
107TNIK0.64812537
108CAMK2D0.63938826
109CAMK2B0.62955771
110CSF1R0.62839857
111DYRK1A0.62324406
112ROCK20.61780886
113PKN10.60784304
114LCK0.60017839
115PRKCG0.59779248
116RPS6KA30.58818159
117MAPK100.56982273
118PTK20.54382677
119CDK150.54366595
120DDR20.54066868
121IRAK10.53633237
122TNK20.53523521
123FYN0.53345480
124SGK20.53230181
125CAMKK20.52138517
126CAMK2G0.52083922
127HIPK20.52056191
128LYN0.50784053
129PIK3CG0.50590845
130CDK140.50545058
131YES10.50337171
132CDK180.49202823
133NEK60.49099449
134MTOR0.48467623
135MAP2K60.47655974
136PRKCZ0.45695892
137CDK11A0.44751733
138IKBKB0.44236026
139ERN10.44098563
140PRKCQ0.43293648
141JAK20.43047743
142MOS0.42367955
143IRAK30.42301434

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.43346564
2GABAergic synapse_Homo sapiens_hsa047272.05003977
3Osteoclast differentiation_Homo sapiens_hsa043801.96400692
4Circadian entrainment_Homo sapiens_hsa047131.91605326
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89275477
6Olfactory transduction_Homo sapiens_hsa047401.85034342
7Synaptic vesicle cycle_Homo sapiens_hsa047211.84739488
8Glutamatergic synapse_Homo sapiens_hsa047241.82397155
9Long-term potentiation_Homo sapiens_hsa047201.81592624
10Nicotine addiction_Homo sapiens_hsa050331.81412026
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79964349
12B cell receptor signaling pathway_Homo sapiens_hsa046621.79170681
13Morphine addiction_Homo sapiens_hsa050321.73576008
14Amphetamine addiction_Homo sapiens_hsa050311.67659532
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.67070567
16Insulin secretion_Homo sapiens_hsa049111.64280613
17Salivary secretion_Homo sapiens_hsa049701.62667206
18Gastric acid secretion_Homo sapiens_hsa049711.57382447
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57311946
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57004625
21Cocaine addiction_Homo sapiens_hsa050301.56428114
22Leishmaniasis_Homo sapiens_hsa051401.55199901
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52384769
24Type II diabetes mellitus_Homo sapiens_hsa049301.46543069
25Dopaminergic synapse_Homo sapiens_hsa047281.43508885
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42984648
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41408593
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40992585
29Cholinergic synapse_Homo sapiens_hsa047251.39988377
30T cell receptor signaling pathway_Homo sapiens_hsa046601.38278591
31Arginine biosynthesis_Homo sapiens_hsa002201.37165952
32Dorso-ventral axis formation_Homo sapiens_hsa043201.36084629
33Acute myeloid leukemia_Homo sapiens_hsa052211.33248205
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31772511
35Bile secretion_Homo sapiens_hsa049761.27700419
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25997075
37Tuberculosis_Homo sapiens_hsa051521.25746052
38Renin secretion_Homo sapiens_hsa049241.25137191
39Oxytocin signaling pathway_Homo sapiens_hsa049211.22356450
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.18778472
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17418084
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17012555
43cAMP signaling pathway_Homo sapiens_hsa040241.16883918
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14979119
45Dilated cardiomyopathy_Homo sapiens_hsa054141.14707501
46GnRH signaling pathway_Homo sapiens_hsa049121.13074199
47Long-term depression_Homo sapiens_hsa047301.12280174
48TNF signaling pathway_Homo sapiens_hsa046681.11044770
49Calcium signaling pathway_Homo sapiens_hsa040201.06455930
50Staphylococcus aureus infection_Homo sapiens_hsa051501.05729454
51Estrogen signaling pathway_Homo sapiens_hsa049151.04893476
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01402733
53Prolactin signaling pathway_Homo sapiens_hsa049171.00295217
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.00241586
55Gap junction_Homo sapiens_hsa045401.00009701
56Malaria_Homo sapiens_hsa051440.99747011
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98939181
58Toxoplasmosis_Homo sapiens_hsa051450.98532114
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98130120
60Glioma_Homo sapiens_hsa052140.97254414
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96279201
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95250906
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.94275369
64Endometrial cancer_Homo sapiens_hsa052130.93071114
65Taste transduction_Homo sapiens_hsa047420.89446924
66Butanoate metabolism_Homo sapiens_hsa006500.88705470
67ErbB signaling pathway_Homo sapiens_hsa040120.88124091
68African trypanosomiasis_Homo sapiens_hsa051430.88017247
69Measles_Homo sapiens_hsa051620.87862687
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.87790930
71Hepatitis C_Homo sapiens_hsa051600.86831827
72Influenza A_Homo sapiens_hsa051640.85820902
73Pancreatic cancer_Homo sapiens_hsa052120.85380342
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84893689
75FoxO signaling pathway_Homo sapiens_hsa040680.84845870
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84807980
77Serotonergic synapse_Homo sapiens_hsa047260.82647081
78Pancreatic secretion_Homo sapiens_hsa049720.82283362
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.80890101
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.80880987
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80401029
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.79780906
83Graft-versus-host disease_Homo sapiens_hsa053320.79665248
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79043683
85Hepatitis B_Homo sapiens_hsa051610.78764796
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76610613
87mTOR signaling pathway_Homo sapiens_hsa041500.75217627
88Notch signaling pathway_Homo sapiens_hsa043300.74738950
89Thyroid hormone synthesis_Homo sapiens_hsa049180.74494495
90Renal cell carcinoma_Homo sapiens_hsa052110.73345334
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73038486
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72982641
93Melanogenesis_Homo sapiens_hsa049160.72970628
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72922941
95Glucagon signaling pathway_Homo sapiens_hsa049220.72334271
96Axon guidance_Homo sapiens_hsa043600.71692641
97MAPK signaling pathway_Homo sapiens_hsa040100.69528948
98Other glycan degradation_Homo sapiens_hsa005110.68761741
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68636843
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68636091
101Choline metabolism in cancer_Homo sapiens_hsa052310.68486949
102Allograft rejection_Homo sapiens_hsa053300.68306126
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68248381
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67789642
105Insulin resistance_Homo sapiens_hsa049310.66976075
106Fatty acid biosynthesis_Homo sapiens_hsa000610.66868802
107Hematopoietic cell lineage_Homo sapiens_hsa046400.66344614
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66111010
109Primary immunodeficiency_Homo sapiens_hsa053400.66006929
110Pertussis_Homo sapiens_hsa051330.65934335
111Cardiac muscle contraction_Homo sapiens_hsa042600.65477671
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.65285955
113VEGF signaling pathway_Homo sapiens_hsa043700.63057451
114Endocytosis_Homo sapiens_hsa041440.62374243
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.61623388
116Insulin signaling pathway_Homo sapiens_hsa049100.60165069
117Lysine degradation_Homo sapiens_hsa003100.60154457
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56415957
119Rap1 signaling pathway_Homo sapiens_hsa040150.55836997
120Prion diseases_Homo sapiens_hsa050200.54899100
121Non-small cell lung cancer_Homo sapiens_hsa052230.54357890
122Inositol phosphate metabolism_Homo sapiens_hsa005620.52079725
123PPAR signaling pathway_Homo sapiens_hsa033200.51612774
124Ovarian steroidogenesis_Homo sapiens_hsa049130.50935021
125Fatty acid metabolism_Homo sapiens_hsa012120.50079439
126AMPK signaling pathway_Homo sapiens_hsa041520.47746584
127Ras signaling pathway_Homo sapiens_hsa040140.47240027
128Proteoglycans in cancer_Homo sapiens_hsa052050.42927438
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.42678434
130Type I diabetes mellitus_Homo sapiens_hsa049400.42508938
131Chemokine signaling pathway_Homo sapiens_hsa040620.41248245
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40215127
133Circadian rhythm_Homo sapiens_hsa047100.40148016
134Platelet activation_Homo sapiens_hsa046110.39117965
135Focal adhesion_Homo sapiens_hsa045100.38523908
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38461011
137Propanoate metabolism_Homo sapiens_hsa006400.37947721
138Amoebiasis_Homo sapiens_hsa051460.36747264
139Chronic myeloid leukemia_Homo sapiens_hsa052200.36030939
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35153523

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