SIL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.38146740
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.38146740
3L-phenylalanine metabolic process (GO:0006558)6.05635903
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.05635903
5sulfur amino acid catabolic process (GO:0000098)5.08074825
6aromatic amino acid family catabolic process (GO:0009074)5.03635349
7COPI coating of Golgi vesicle (GO:0048205)4.92596673
8Golgi transport vesicle coating (GO:0048200)4.92596673
9cysteine metabolic process (GO:0006534)4.65561975
10alpha-linolenic acid metabolic process (GO:0036109)4.43261333
11glyoxylate metabolic process (GO:0046487)4.39150840
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.19632327
13high-density lipoprotein particle remodeling (GO:0034375)4.16604526
14peptidyl-glutamic acid carboxylation (GO:0017187)4.13725529
15protein carboxylation (GO:0018214)4.13725529
16bile acid biosynthetic process (GO:0006699)4.13299864
17valine metabolic process (GO:0006573)4.09301557
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.05693546
19protein maturation by protein folding (GO:0022417)4.01551531
20cellular modified amino acid catabolic process (GO:0042219)3.97572406
21indole-containing compound catabolic process (GO:0042436)3.94282539
22indolalkylamine catabolic process (GO:0046218)3.94282539
23tryptophan catabolic process (GO:0006569)3.94282539
24coenzyme catabolic process (GO:0009109)3.91541952
25complement activation, alternative pathway (GO:0006957)3.90346670
26oligosaccharide catabolic process (GO:0009313)3.88956246
27tryptophan metabolic process (GO:0006568)3.86146797
28kynurenine metabolic process (GO:0070189)3.85244450
29lysine catabolic process (GO:0006554)3.84609114
30lysine metabolic process (GO:0006553)3.84609114
31urea metabolic process (GO:0019627)3.83901725
32urea cycle (GO:0000050)3.83901725
33negative regulation of fibrinolysis (GO:0051918)3.81442771
34reverse cholesterol transport (GO:0043691)3.80609522
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.80349294
36regulation of protein activation cascade (GO:2000257)3.77069312
37protein-lipid complex remodeling (GO:0034368)3.73530398
38macromolecular complex remodeling (GO:0034367)3.73530398
39plasma lipoprotein particle remodeling (GO:0034369)3.73530398
40aromatic amino acid family metabolic process (GO:0009072)3.73125849
41intestinal cholesterol absorption (GO:0030299)3.72983839
42bile acid metabolic process (GO:0008206)3.71189382
43regulation of cholesterol esterification (GO:0010872)3.67684406
44barbed-end actin filament capping (GO:0051016)3.64275164
45COPII vesicle coating (GO:0048208)3.63313406
46regulation of fibrinolysis (GO:0051917)3.60667760
47tyrosine metabolic process (GO:0006570)3.59737965
48glycosphingolipid catabolic process (GO:0046479)3.59327415
49regulation of complement activation (GO:0030449)3.59122070
50nitrogen cycle metabolic process (GO:0071941)3.59086711
51maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.57797274
52low-density lipoprotein particle remodeling (GO:0034374)3.56000911
53signal peptide processing (GO:0006465)3.54910367
54regulation of triglyceride catabolic process (GO:0010896)3.54770398
55cellular amino acid catabolic process (GO:0009063)3.54767001
56homocysteine metabolic process (GO:0050667)3.54393164
57alpha-amino acid catabolic process (GO:1901606)3.53407261
58branched-chain amino acid catabolic process (GO:0009083)3.51855851
59ethanol oxidation (GO:0006069)3.47427202
60regulation of cholesterol biosynthetic process (GO:0045540)3.44044655
61short-chain fatty acid metabolic process (GO:0046459)3.42723222
62cellular ketone body metabolic process (GO:0046950)3.41377675
63aldehyde catabolic process (GO:0046185)3.41140086
64keratan sulfate catabolic process (GO:0042340)3.40936238
65aspartate family amino acid catabolic process (GO:0009068)3.39314494
66branched-chain amino acid metabolic process (GO:0009081)3.39025237
67cofactor catabolic process (GO:0051187)3.38274532
68amino-acid betaine metabolic process (GO:0006577)3.38229383
69glycolipid catabolic process (GO:0019377)3.36297058
70plasma lipoprotein particle clearance (GO:0034381)3.35526976
71serine family amino acid catabolic process (GO:0009071)3.34932293
724-hydroxyproline metabolic process (GO:0019471)3.34921978
73triglyceride homeostasis (GO:0070328)3.33072570
74acylglycerol homeostasis (GO:0055090)3.33072570
75regulation of cholesterol metabolic process (GO:0090181)3.33028041
76bile acid and bile salt transport (GO:0015721)3.33017877
77drug transmembrane transport (GO:0006855)3.31493383
78cellular glucuronidation (GO:0052695)3.30393198
79serine family amino acid biosynthetic process (GO:0009070)3.30219890
80GDP-mannose metabolic process (GO:0019673)3.28901023
81organic acid catabolic process (GO:0016054)3.25290736
82carboxylic acid catabolic process (GO:0046395)3.25290736
832-oxoglutarate metabolic process (GO:0006103)3.24240707
84fatty acid beta-oxidation (GO:0006635)3.23173670
85regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.22255336
86protein retention in ER lumen (GO:0006621)3.21727950
87serine family amino acid metabolic process (GO:0009069)3.20624127
88glucuronate metabolic process (GO:0019585)3.19987706
89uronic acid metabolic process (GO:0006063)3.19987706
90fatty acid catabolic process (GO:0009062)3.19915867
91fatty acid oxidation (GO:0019395)3.17094337
92monocarboxylic acid catabolic process (GO:0072329)3.16310797
93lipid oxidation (GO:0034440)3.12433502
94hormone catabolic process (GO:0042447)3.11440178
95negative regulation of cholesterol transport (GO:0032375)3.10967715
96negative regulation of sterol transport (GO:0032372)3.10967715
97indolalkylamine metabolic process (GO:0006586)3.09445470
98benzene-containing compound metabolic process (GO:0042537)3.07498435
99amino sugar catabolic process (GO:0046348)3.07468092
100phospholipid efflux (GO:0033700)3.07461649
101complement activation, classical pathway (GO:0006958)3.06994351
102pinocytosis (GO:0006907)3.06517492
103response to nitrosative stress (GO:0051409)3.06407315
104cholesterol efflux (GO:0033344)3.04136759
105glutamate metabolic process (GO:0006536)3.01325042
106positive regulation of triglyceride lipase activity (GO:0061365)3.01277113
107positive regulation of lipoprotein lipase activity (GO:0051006)3.01277113
108endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.01142921
109adhesion of symbiont to host (GO:0044406)3.00466739
110regulation of cholesterol homeostasis (GO:2000188)2.99761072
111acetyl-CoA metabolic process (GO:0006084)2.96234374
112ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.96094843
113retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96028280
114virion attachment to host cell (GO:0019062)2.94658609
115adhesion of symbiont to host cell (GO:0044650)2.94658609
116ceramide catabolic process (GO:0046514)2.94161176
117regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.93558705
118response to thyroid hormone (GO:0097066)2.93256051
119hyaluronan catabolic process (GO:0030214)2.85706236
120negative regulation of nitric oxide biosynthetic process (GO:0045019)2.85317064
121xenobiotic catabolic process (GO:0042178)2.82775160
122sphingolipid catabolic process (GO:0030149)2.79507749
123protein localization to endosome (GO:0036010)2.79345957
124amyloid precursor protein catabolic process (GO:0042987)2.78666475
125membrane lipid catabolic process (GO:0046466)2.78666006
126type B pancreatic cell proliferation (GO:0044342)2.77199946
127skin morphogenesis (GO:0043589)2.70031556
128low-density lipoprotein particle clearance (GO:0034383)2.66024217
129mannose metabolic process (GO:0006013)2.64215512
130polyketide metabolic process (GO:0030638)2.61679692
131doxorubicin metabolic process (GO:0044598)2.61679692
132daunorubicin metabolic process (GO:0044597)2.61679692
133regulation of metalloenzyme activity (GO:0048552)2.61464531
134glucose catabolic process (GO:0006007)2.59430660
135extracellular fibril organization (GO:0043206)2.58812382
136pentose-phosphate shunt (GO:0006098)2.53709960
137regulation of cholesterol storage (GO:0010885)2.52475718
138fibril organization (GO:0097435)2.52043292
139apoptotic cell clearance (GO:0043277)2.49981256
140fibrinolysis (GO:0042730)2.46869443
141galactose catabolic process (GO:0019388)2.44900070
142positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.44461998
143glycoside metabolic process (GO:0016137)2.42487180
144negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.41665014
145cell adhesion mediated by integrin (GO:0033627)2.40972702
146cellular copper ion homeostasis (GO:0006878)2.35382686
147cellular response to thyroid hormone stimulus (GO:0097067)2.35326844
148UV protection (GO:0009650)2.32339683
149glucosamine-containing compound catabolic process (GO:1901072)2.30921232
150regulation of extracellular matrix disassembly (GO:0010715)2.30346974
151endosome to pigment granule transport (GO:0043485)2.28939261
152endosome to melanosome transport (GO:0035646)2.28939261
153cellular response to zinc ion (GO:0071294)2.28041687
154regulation of membrane protein ectodomain proteolysis (GO:0051043)2.27522692
155positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.23647032
156cellular response to arsenic-containing substance (GO:0071243)2.23595636
157aminoglycoside antibiotic metabolic process (GO:0030647)2.21684610
158cellular response to cadmium ion (GO:0071276)2.20487468
159regulation of plasminogen activation (GO:0010755)2.20165629
160positive regulation of fatty acid biosynthetic process (GO:0045723)2.19891515
161L-ascorbic acid metabolic process (GO:0019852)2.17589394
162acute-phase response (GO:0006953)2.17490743
163positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.16536747
164negative regulation of protein activation cascade (GO:2000258)2.16498959
165regulation of apoptotic process involved in morphogenesis (GO:1902337)2.15866551
166deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.13208855
167NADPH regeneration (GO:0006740)2.13089626
168NADH metabolic process (GO:0006734)2.13015205
169activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.12457984
170negative regulation of complement activation (GO:0045916)2.12217286
171fat-soluble vitamin biosynthetic process (GO:0042362)2.10653593
172regulation of superoxide anion generation (GO:0032928)2.10187945
173lipopolysaccharide biosynthetic process (GO:0009103)2.09065601
174hemidesmosome assembly (GO:0031581)2.08510693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.11114921
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.33829487
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.55344986
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.97185559
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.77506017
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.47155791
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.39476070
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.33689273
9* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.59004625
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.36441249
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72591599
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44862200
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.34796165
14GATA1_22025678_ChIP-Seq_K562_Human2.29084999
15ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.23452763
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.01673113
17CLOCK_20551151_ChIP-Seq_293T_Human1.92946172
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.90424913
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.85010722
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.79929196
21RACK7_27058665_Chip-Seq_MCF-7_Human1.75214901
22VDR_21846776_ChIP-Seq_THP-1_Human1.73531649
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71734763
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67410969
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.65747588
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64329982
27TFEB_21752829_ChIP-Seq_HELA_Human1.63768367
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56118583
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54364581
30ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.46586437
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44385844
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40097383
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37898867
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.36302574
35VDR_24763502_ChIP-Seq_THP-1_Human1.35556592
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32004602
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29935060
38ATF3_27146783_Chip-Seq_COLON_Human1.29761961
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29145337
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.28057886
41GATA4_25053715_ChIP-Seq_YYC3_Human1.25079682
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.23799104
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22180783
44HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21357911
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21096754
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20737183
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19469773
48FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.18325064
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17800454
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16710007
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.14726411
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13883664
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13390623
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.12051194
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11224331
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.11037676
57CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09253534
58AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09106483
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08963794
60BCL6_27268052_Chip-Seq_Bcells_Human1.08190856
61SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08164116
62MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08149932
63ERG_20517297_ChIP-Seq_VCAP_Human1.08070643
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07841034
65HTT_18923047_ChIP-ChIP_STHdh_Human1.07192974
66IRF8_27001747_Chip-Seq_BMDM_Mouse1.06867451
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.06207373
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04789865
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04789865
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04627590
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04466606
72MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04424847
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04331772
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03596597
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.03168120
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03098567
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02650196
78SPI1_23127762_ChIP-Seq_K562_Human1.01904272
79* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01613114
80TP53_22127205_ChIP-Seq_IMR90_Human1.01078424
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00871217
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00365571
83ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99264046
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98884962
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98842612
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98536433
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98413031
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98357880
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98250546
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97949914
91ZNF263_19887448_ChIP-Seq_K562_Human0.97402337
92STAT1_20625510_ChIP-Seq_HELA_Human0.96224116
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95878195
94P68_20966046_ChIP-Seq_HELA_Human0.95451729
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95187911
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95174794
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93891947
98TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91699118
99TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91368686
100RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91175691
101AR_20517297_ChIP-Seq_VCAP_Human0.90482419
102SOX2_20726797_ChIP-Seq_SW620_Human0.90451084
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86228089
104LXR_22292898_ChIP-Seq_THP-1_Human0.84483951
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83763133
106FOXA1_25552417_ChIP-Seq_VCAP_Human0.83319072
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82447711
108RARA_24833708_ChIP-Seq_LIVER_Mouse0.81886342
109TRIM28_21343339_ChIP-Seq_HEK293_Human0.80420164
110FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78022024
111P53_21459846_ChIP-Seq_SAOS-2_Human0.76697255
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76057307
113* GATA3_24758297_ChIP-Seq_MCF-7_Human0.75144410
114* RARB_24833708_ChIP-Seq_LIVER_Mouse0.74882406
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74831067
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.74652603
117TET1_21451524_ChIP-Seq_MESCs_Mouse0.74305893
118SRF_21415370_ChIP-Seq_HL-1_Mouse0.73426804
119SOX2_22085726_ChIP-Seq_NPCs_Mouse0.73375569
120TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72808494
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.72550764
122LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71930284
123FOXO3_23340844_ChIP-Seq_DLD1_Human0.71300967
124MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.70712872
125* ESET_19884257_ChIP-Seq_ESCs_Mouse0.70210573
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.68820929
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.68494726
128CTCF_20526341_ChIP-Seq_ESCs_Human0.68293012
129* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.67852941
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67744745
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.67724800
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67365341
133* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.67255195
134BCOR_27268052_Chip-Seq_Bcells_Human0.66802762
135GATA2_21666600_ChIP-Seq_HMVEC_Human0.66320543
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66214226
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.65312834
138GATA6_25053715_ChIP-Seq_YYC3_Human0.64968882
139FOXH1_21741376_ChIP-Seq_ESCs_Human0.64438660
140ELF1_20517297_ChIP-Seq_JURKAT_Human0.64109297
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63816527
142NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63623698
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63623698
144* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.63212484
145EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.63044354
146OCT4_20526341_ChIP-Seq_ESCs_Human0.62955870
147P63_26484246_Chip-Seq_KERATINOCYTES_Human0.61216366
148* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59284502
149PU.1_20513432_ChIP-Seq_Bcells_Mouse0.58547357
150CEBPB_22108803_ChIP-Seq_LS180_Human0.58421554
151BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.57598432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.54392403
2MP0005365_abnormal_bile_salt5.45706097
3MP0005360_urolithiasis5.22988418
4MP0005085_abnormal_gallbladder_physiolo4.76147528
5MP0003806_abnormal_nucleotide_metabolis3.96619255
6MP0008875_abnormal_xenobiotic_pharmacok3.78946918
7MP0005083_abnormal_biliary_tract3.38687621
8MP0001666_abnormal_nutrient_absorption3.11846221
9MP0003195_calcinosis2.89423734
10MP0010329_abnormal_lipoprotein_level2.88710453
11MP0009840_abnormal_foam_cell2.88531932
12MP0003252_abnormal_bile_duct2.85915697
13MP0005332_abnormal_amino_acid2.66100746
14MP0003868_abnormal_feces_composition2.47068433
15MP0005058_abnormal_lysosome_morphology2.22351370
16MP0002118_abnormal_lipid_homeostasis2.08849643
17MP0003191_abnormal_cellular_cholesterol2.08000802
18MP0005220_abnormal_exocrine_pancreas1.98222803
19MP0001764_abnormal_homeostasis1.91070798
20MP0009643_abnormal_urine_homeostasis1.87699137
21MP0003279_aneurysm1.84878288
22MP0004272_abnormal_basement_membrane1.82507468
23MP0000609_abnormal_liver_physiology1.81483784
24MP0010234_abnormal_vibrissa_follicle1.80384747
25MP0003075_altered_response_to1.78994355
26MP0004019_abnormal_vitamin_homeostasis1.75454367
27MP0005257_abnormal_intraocular_pressure1.73229424
28MP0003186_abnormal_redox_activity1.68936720
29MP0005165_increased_susceptibility_to1.68686651
30MP0004043_abnormal_pH_regulation1.67639545
31MP0000343_altered_response_to1.66640561
32MP0005319_abnormal_enzyme/_coenzyme1.66595296
33MP0005275_abnormal_skin_tensile1.63306386
34MP0005023_abnormal_wound_healing1.53736310
35MP0003183_abnormal_peptide_metabolism1.53184849
36MP0005410_abnormal_fertilization1.53057871
37MP0002148_abnormal_hypersensitivity_rea1.50050029
38MP0001542_abnormal_bone_strength1.48340490
39MP0005636_abnormal_mineral_homeostasis1.46451428
40MP0005584_abnormal_enzyme/coenzyme_acti1.39937809
41MP0005670_abnormal_white_adipose1.37713783
42MP0002909_abnormal_adrenal_gland1.36711580
43MP0003566_abnormal_cell_adhesion1.36561534
44MP0002138_abnormal_hepatobiliary_system1.36448249
45MP0001958_emphysema1.35885826
46MP0003436_decreased_susceptibility_to1.35375489
47MP0003656_abnormal_erythrocyte_physiolo1.30666864
48MP0001533_abnormal_skeleton_physiology1.26605591
49MP0000858_altered_metastatic_potential1.22079134
50MP0003172_abnormal_lysosome_physiology1.20661490
51MP0005647_abnormal_sex_gland1.20377090
52MP0008260_abnormal_autophagy1.18959959
53MP0004510_myositis1.18296662
54MP0002419_abnormal_innate_immunity1.17583942
55MP0001944_abnormal_pancreas_morphology1.17508055
56MP0003453_abnormal_keratinocyte_physiol1.16629250
57MP0002254_reproductive_system_inflammat1.15606043
58MP0001853_heart_inflammation1.15462538
59MP0009785_altered_susceptibility_to1.15208748
60MP0002078_abnormal_glucose_homeostasis1.15044215
61MP0008438_abnormal_cutaneous_collagen1.14802892
62MP0003300_gastrointestinal_ulcer1.12453091
63MP0001765_abnormal_ion_homeostasis1.11113331
64MP0005164_abnormal_response_to1.10833007
65MP0002693_abnormal_pancreas_physiology1.09766125
66MP0000598_abnormal_liver_morphology1.08676467
67MP0001756_abnormal_urination1.07737834
68MP0005379_endocrine/exocrine_gland_phen1.07404322
69MP0000013_abnormal_adipose_tissue1.07340137
70MP0002876_abnormal_thyroid_physiology1.07144892
71MP0002998_abnormal_bone_remodeling1.04215964
72MP0001243_abnormal_dermal_layer1.03463720
73MP0003303_peritoneal_inflammation1.02534864
74MP0009780_abnormal_chondrocyte_physiolo1.01565546
75MP0004264_abnormal_extraembryonic_tissu1.01201743
76MP0006036_abnormal_mitochondrial_physio1.01015717
77MP0005666_abnormal_adipose_tissue1.00873262
78MP0000681_abnormal_thyroid_gland1.00160433
79MP0000604_amyloidosis0.99217723
80MP0005084_abnormal_gallbladder_morpholo0.97188399
81MP0005408_hypopigmentation0.96618763
82MP0005451_abnormal_body_composition0.95442952
83MP0009642_abnormal_blood_homeostasis0.94796478
84MP0003011_delayed_dark_adaptation0.94277693
85MP0001881_abnormal_mammary_gland0.94271937
86MP0008469_abnormal_protein_level0.93248529
87MP0002877_abnormal_melanocyte_morpholog0.93043228
88MP0001545_abnormal_hematopoietic_system0.91324153
89MP0005397_hematopoietic_system_phenotyp0.91324153
90MP0002295_abnormal_pulmonary_circulatio0.89811142
91MP0008004_abnormal_stomach_pH0.89694748
92MP0005025_abnormal_response_to0.88355695
93MP0005166_decreased_susceptibility_to0.87988146
94MP0003950_abnormal_plasma_membrane0.87701578
95MP0006054_spinal_hemorrhage0.86917516
96MP0005535_abnormal_body_temperature0.85965783
97MP0003091_abnormal_cell_migration0.85938584
98MP0000685_abnormal_immune_system0.84929137
99MP0009763_increased_sensitivity_to0.84325084
100MP0005390_skeleton_phenotype0.84092209
101MP0006082_CNS_inflammation0.83684085
102MP0001835_abnormal_antigen_presentation0.83277291
103MP0003724_increased_susceptibility_to0.80950662
104MP0002837_dystrophic_cardiac_calcinosis0.80635236
105MP0005330_cardiomyopathy0.80546460
106MP0003795_abnormal_bone_structure0.80264629
107MP0005503_abnormal_tendon_morphology0.79605438
108MP0009764_decreased_sensitivity_to0.78897412
109MP0005334_abnormal_fat_pad0.78625258
110MP0000538_abnormal_urinary_bladder0.78337732
111MP0001216_abnormal_epidermal_layer0.78302639
112MP0003329_amyloid_beta_deposits0.77812395
113MP0001661_extended_life_span0.76474460
114MP0001849_ear_inflammation0.75744381
115MP0004858_abnormal_nervous_system0.75036083
116MP0005376_homeostasis/metabolism_phenot0.74582922
117MP0000613_abnormal_salivary_gland0.74468348
118MP0005375_adipose_tissue_phenotype0.74289708
119MP0004947_skin_inflammation0.74250813
120MP0002796_impaired_skin_barrier0.74054754
121MP0003953_abnormal_hormone_level0.73339010
122MP0009765_abnormal_xenobiotic_induced0.73216935
123MP0005448_abnormal_energy_balance0.72533019
124MP0003705_abnormal_hypodermis_morpholog0.72299351
125MP0002136_abnormal_kidney_physiology0.72029471
126MP0003959_abnormal_lean_body0.72022226
127MP0000639_abnormal_adrenal_gland0.71904649
128MP0004130_abnormal_muscle_cell0.69796726
129MP0009697_abnormal_copulation0.68312454
130MP0001664_abnormal_digestion0.67286882
131MP0005464_abnormal_platelet_physiology0.66036807
132MP0000230_abnormal_systemic_arterial0.66006547
133MP0009384_cardiac_valve_regurgitation0.65977493
134MP0003638_abnormal_response/metabolism_0.65429619
135MP0004782_abnormal_surfactant_physiolog0.64509101
136MP0003690_abnormal_glial_cell0.63993867
137MP0002971_abnormal_brown_adipose0.62187401
138MP0010386_abnormal_urinary_bladder0.61483193
139MP0003283_abnormal_digestive_organ0.59185630
140MP0010368_abnormal_lymphatic_system0.55137928
141MP0002168_other_aberrant_phenotype0.53089076
142MP0000462_abnormal_digestive_system0.52668279
143MP0001845_abnormal_inflammatory_respons0.52267573
144MP0002896_abnormal_bone_mineralization0.51853810
145MP0002060_abnormal_skin_morphology0.51667014
146MP0000003_abnormal_adipose_tissue0.50862393

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.34614527
2Abnormality of glycolipid metabolism (HP:0010969)6.02285565
3Abnormality of liposaccharide metabolism (HP:0010968)6.02285565
4Abnormality of glycosphingolipid metabolism (HP:0004343)6.02285565
5Intrahepatic cholestasis (HP:0001406)5.26104505
6Xanthomatosis (HP:0000991)4.83187576
7Deep venous thrombosis (HP:0002625)4.82216240
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.53838636
9Prolonged partial thromboplastin time (HP:0003645)4.47745879
10Ketosis (HP:0001946)4.36009862
11Abnormality of the intrinsic pathway (HP:0010989)4.30879740
12Hypoglycemic coma (HP:0001325)4.26845911
13Vertebral compression fractures (HP:0002953)4.18107590
14Premature rupture of membranes (HP:0001788)4.02977103
15Hyperlipoproteinemia (HP:0010980)3.92513730
16Hypobetalipoproteinemia (HP:0003563)3.83864566
17Ketoacidosis (HP:0001993)3.81679280
18Complement deficiency (HP:0004431)3.75248645
19Fat malabsorption (HP:0002630)3.74316088
20Abnormality of the common coagulation pathway (HP:0010990)3.69414556
21Hyperammonemia (HP:0001987)3.49020498
22Loss of speech (HP:0002371)3.38333462
23Abnormality of glycine metabolism (HP:0010895)3.26648004
24Abnormality of serine family amino acid metabolism (HP:0010894)3.26648004
25Hyperglycinuria (HP:0003108)3.25032865
26Abnormality of fatty-acid metabolism (HP:0004359)3.24626949
27Conjugated hyperbilirubinemia (HP:0002908)3.20855339
28Protrusio acetabuli (HP:0003179)3.20779121
29Gout (HP:0001997)3.20618126
30Generalized aminoaciduria (HP:0002909)3.18759484
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17435976
32Steatorrhea (HP:0002570)3.15313319
33Hypoglycemic seizures (HP:0002173)3.15138357
34Hyperglycinemia (HP:0002154)3.14373178
35Dysostosis multiplex (HP:0000943)3.13419120
36Hypolipoproteinemia (HP:0010981)3.10636667
37Abnormality of sulfur amino acid metabolism (HP:0004339)3.09451034
38Urinary glycosaminoglycan excretion (HP:0003541)2.97667800
39Mucopolysacchariduria (HP:0008155)2.97667800
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.95807549
41Increased cerebral lipofuscin (HP:0011813)2.94339983
42Abnormality of methionine metabolism (HP:0010901)2.93583984
43Prolonged neonatal jaundice (HP:0006579)2.93559396
44Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.92810618
45Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91178064
46Epidermoid cyst (HP:0200040)2.90269113
47Hypoalphalipoproteinemia (HP:0003233)2.89354191
48Abnormality of dicarboxylic acid metabolism (HP:0010995)2.88475424
49Dicarboxylic aciduria (HP:0003215)2.88475424
50Joint hemorrhage (HP:0005261)2.86778673
51Hyperinsulinemic hypoglycemia (HP:0000825)2.85302793
52Abnormality of complement system (HP:0005339)2.80204121
53Abnormality of purine metabolism (HP:0004352)2.74731050
54Abnormality of polysaccharide metabolism (HP:0011012)2.73609134
55Abnormality of glycosaminoglycan metabolism (HP:0004371)2.73609134
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.73609134
57Protuberant abdomen (HP:0001538)2.73057076
58Axonal loss (HP:0003447)2.69968072
59Nuclear cataract (HP:0100018)2.69623375
60Glomerulonephritis (HP:0000099)2.67541076
61Hyperbilirubinemia (HP:0002904)2.66632462
62Vacuolated lymphocytes (HP:0001922)2.63707897
63Late onset (HP:0003584)2.63315200
64Cervical subluxation (HP:0003308)2.56674457
65Joint stiffness (HP:0001387)2.54696611
66Vascular calcification (HP:0004934)2.53156006
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.48319607
68Pancreatitis (HP:0001733)2.43615032
69Lethargy (HP:0001254)2.39245096
70Metabolic acidosis (HP:0001942)2.38666420
71Abnormality of nucleobase metabolism (HP:0010932)2.38504151
72Atrophic scars (HP:0001075)2.36377662
73Cardiomegaly (HP:0001640)2.33071728
74Cardiovascular calcification (HP:0011915)2.31546575
75Symptomatic seizures (HP:0011145)2.30191710
76Cerebral edema (HP:0002181)2.27479248
77Opisthotonus (HP:0002179)2.26612303
78J-shaped sella turcica (HP:0002680)2.26339407
79Hypercholesterolemia (HP:0003124)2.26197823
80Progressive neurologic deterioration (HP:0002344)2.21556316
81Abnormality of macrophages (HP:0004311)2.21078910
82Systemic lupus erythematosus (HP:0002725)2.20257546
83Interstitial pulmonary disease (HP:0006530)2.17897980
84Short nail (HP:0001799)2.16144713
85Methylmalonic aciduria (HP:0012120)2.15439792
86Skin nodule (HP:0200036)2.14153210
87Purpura (HP:0000979)2.14130412
88Myocardial infarction (HP:0001658)2.12972322
89Irritability (HP:0000737)2.12831694
90Abnormality of serum amino acid levels (HP:0003112)2.10347844
91Mitral stenosis (HP:0001718)2.07677556
92Vomiting (HP:0002013)2.07616502
93Hepatocellular carcinoma (HP:0001402)2.07191983
94Hypokinesia (HP:0002375)2.05939749
95Proximal tubulopathy (HP:0000114)2.05888672
96Delayed CNS myelination (HP:0002188)2.04755861
97Abnormality of endocrine pancreas physiology (HP:0012093)2.03822483
98Abnormality of the pancreatic islet cells (HP:0006476)2.03822483
99Hepatosplenomegaly (HP:0001433)2.02224004
100Abdominal distention (HP:0003270)2.02167458
101Nonimmune hydrops fetalis (HP:0001790)2.01440100
102Brushfield spots (HP:0001088)2.01179842
103Distal lower limb muscle weakness (HP:0009053)2.00654764
104Abnormality of the Achilles tendon (HP:0005109)2.00159045
105Abnormal enzyme/coenzyme activity (HP:0012379)1.98241343
106Petechiae (HP:0000967)1.98126545
107Achilles tendon contracture (HP:0001771)1.98048461
108Fragile skin (HP:0001030)1.96102504
109Abnormal tarsal ossification (HP:0008369)1.95145625
110Abnormal gallbladder morphology (HP:0012437)1.93594983
111Ovoid vertebral bodies (HP:0003300)1.93459204
112Beaking of vertebral bodies (HP:0004568)1.92308737
113Amyloidosis (HP:0011034)1.92206449
114Type I transferrin isoform profile (HP:0003642)1.92098221
115Osteolytic defects of the hand bones (HP:0009699)1.91636381
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.91636381
117Retinal atrophy (HP:0001105)1.90572681
118Increased serum ferritin (HP:0003281)1.89305727
119Hepatic necrosis (HP:0002605)1.88430096
120Hyperglycemia (HP:0003074)1.88423012
121Elevated alkaline phosphatase (HP:0003155)1.88223610
122Hyperuricemia (HP:0002149)1.88023423
123Increased purine levels (HP:0004368)1.88023423
124Abnormality of urine glucose concentration (HP:0011016)1.85748449
125Glycosuria (HP:0003076)1.85748449
126Rhabdomyolysis (HP:0003201)1.83940627
127Nephritis (HP:0000123)1.83581421
128Hydroxyprolinuria (HP:0003080)1.83411514
129Abnormality of proline metabolism (HP:0010907)1.83411514
130Abnormality of alkaline phosphatase activity (HP:0004379)1.83256647
131Sensorimotor neuropathy (HP:0007141)1.82945987
132Generalized amyotrophy (HP:0003700)1.82762370
133Distal upper limb amyotrophy (HP:0007149)1.81542267
134Upper limb amyotrophy (HP:0009129)1.81542267
135Abnormal foot bone ossification (HP:0010675)1.79992844
136Wormian bones (HP:0002645)1.79979587
137Reduced antithrombin III activity (HP:0001976)1.79645764
138Asymmetric septal hypertrophy (HP:0001670)1.77408845
139Cholecystitis (HP:0001082)1.75555753
140Abnormal gallbladder physiology (HP:0012438)1.75555753
141Spondylolisthesis (HP:0003302)1.74086273
142Ragged-red muscle fibers (HP:0003200)1.70915512
143Abnormality of dentin (HP:0010299)1.70166427
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70068109
145Abnormal protein N-linked glycosylation (HP:0012347)1.70068109
146Abnormal protein glycosylation (HP:0012346)1.70068109
147Abnormal glycosylation (HP:0012345)1.70068109
148Blue sclerae (HP:0000592)1.69842887
149Cerebral aneurysm (HP:0004944)1.68673000
150Malnutrition (HP:0004395)1.67565752
151Elbow flexion contracture (HP:0002987)1.64709896
152Neurofibrillary tangles (HP:0002185)1.64085339
153Tetraparesis (HP:0002273)1.64038886
154Hand muscle atrophy (HP:0009130)1.60189341
155Stroke (HP:0001297)1.60180702
156Decreased activity of mitochondrial respiratory chain (HP:0008972)1.59548311
157Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.59548311
158Glucose intolerance (HP:0000833)1.58524851
159Follicular hyperkeratosis (HP:0007502)1.58289231
160Abnormality of the distal phalanges of the toes (HP:0010182)1.57218900
161Esophageal neoplasm (HP:0100751)1.56013568
162Neoplasm of head and neck (HP:0012288)1.56013568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.93551046
2BCKDK5.84292110
3ERN14.40188360
4TAOK33.09403113
5SIK12.80759393
6INSRR2.73434261
7TRIB32.39980635
8WNK42.13986824
9ARAF2.06773293
10FGFR42.05528559
11PDK32.03732877
12PDK42.03732877
13STK391.99623828
14FRK1.92833361
15EPHB11.92833215
16PASK1.92153054
17PIK3CG1.88293731
18TESK11.79246953
19MAP3K21.76603766
20SCYL21.73450880
21IRAK11.72260416
22PDK21.66859296
23FLT31.61670021
24NME21.55534454
25STK161.45859663
26MAP2K21.38421189
27DDR21.36971166
28PKN21.31759861
29PAK41.31645246
30MAP3K31.25224800
31EPHA31.24375591
32MAP3K141.22819215
33TRPM71.19528019
34PTK61.18005302
35MST1R1.16494182
36TLK11.16456925
37DAPK31.14605858
38TAOK21.11439771
39MAPKAPK31.09492116
40MOS1.07106765
41MAPKAPK51.05789886
42PRKD21.04074985
43VRK21.02997753
44IKBKB1.02799265
45TTN1.02430231
46MST40.97462194
47TYK20.97343673
48GRK70.95437529
49EEF2K0.93436274
50CDC42BPA0.92610133
51EPHB20.91414283
52PHKG10.90683869
53PHKG20.90683869
54TBK10.86456210
55HIPK20.83424040
56ILK0.82881718
57MET0.82873241
58EIF2AK30.81968896
59MYLK0.81593198
60MUSK0.81590319
61SMG10.80448669
62LRRK20.78099713
63BTK0.76077969
64JAK20.75563666
65OXSR10.74728175
66IRAK30.74587721
67MAP4K10.72888437
68ERBB40.72095048
69BLK0.70483810
70TGFBR20.67171726
71KDR0.66589156
72LMTK20.66045382
73MAP3K10.65825549
74ABL20.65679320
75WNK30.64679612
76JAK10.63463219
77PDPK10.62437097
78CSK0.61467543
79MAP2K30.60786568
80TAOK10.60443912
81ZAP700.60082806
82EPHA20.59413553
83PRKD30.59342629
84KIT0.56806762
85TESK20.56679487
86DYRK1B0.56623468
87RPS6KB20.54022892
88NLK0.52915925
89MAPK110.52004589
90PINK10.51627354
91CSF1R0.51579360
92PDK10.49539665
93MAP3K120.49399691
94LIMK10.45540560
95RPS6KA20.45124023
96NEK90.45117747
97JAK30.44955749
98MAP3K130.44683427
99CHUK0.44369515
100TEC0.43898172
101PTK20.42505501
102MAP3K110.42461174
103PRKAA20.42312688
104GSK3A0.42263492
105CAMK2G0.41825110
106PAK20.39914427
107STK380.37995698
108ITK0.37507944
109MAP3K50.37031583
110MAP2K10.36199082
111RET0.35443756
112AKT30.35369752
113PRKCI0.35080103
114CAMKK20.34645687
115ICK0.33985864
116MAPKAPK20.33621629
117PAK10.32762675
118MAP3K60.32744139
119AKT20.32183352
120IGF1R0.32135462
121PRKG20.30022036
122PIM20.28153521
123FER0.26458545
124PDGFRB0.26326454
125TIE10.26143664
126RIPK10.25243108
127IKBKE0.25043979
128PRKCQ0.24882073
129PRKACG0.24687495
130PDGFRA0.21730506
131RPS6KB10.21651335
132PRKAA10.20479882
133MTOR0.19977634
134TGFBR10.17943455
135MAP2K60.17913399
136PRKD10.17569205

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.22453676
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.89870992
3Sulfur metabolism_Homo sapiens_hsa009202.72504799
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.71440054
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.46352941
6Nitrogen metabolism_Homo sapiens_hsa009102.44546682
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.44133330
8Fatty acid degradation_Homo sapiens_hsa000712.41621181
9Propanoate metabolism_Homo sapiens_hsa006402.38894006
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30043105
11Tryptophan metabolism_Homo sapiens_hsa003802.27593813
12Protein export_Homo sapiens_hsa030602.26683575
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.19604105
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19092516
15Butanoate metabolism_Homo sapiens_hsa006502.17664292
16Arginine biosynthesis_Homo sapiens_hsa002201.97980805
17Peroxisome_Homo sapiens_hsa041461.97758612
18Complement and coagulation cascades_Homo sapiens_hsa046101.97663237
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92881100
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.90163078
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.88080954
22Histidine metabolism_Homo sapiens_hsa003401.83919474
23Fatty acid metabolism_Homo sapiens_hsa012121.81877970
24Folate biosynthesis_Homo sapiens_hsa007901.75757508
25Pyruvate metabolism_Homo sapiens_hsa006201.75702914
26Fatty acid elongation_Homo sapiens_hsa000621.75235831
27Selenocompound metabolism_Homo sapiens_hsa004501.67194306
28Chemical carcinogenesis_Homo sapiens_hsa052041.66911840
29PPAR signaling pathway_Homo sapiens_hsa033201.66508489
30Caffeine metabolism_Homo sapiens_hsa002321.65958498
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65703803
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.64038723
33Fat digestion and absorption_Homo sapiens_hsa049751.52093341
34beta-Alanine metabolism_Homo sapiens_hsa004101.47124476
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.46341238
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.46227261
37* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43703827
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43569238
39Steroid biosynthesis_Homo sapiens_hsa001001.39117066
40Rheumatoid arthritis_Homo sapiens_hsa053231.36558563
41Starch and sucrose metabolism_Homo sapiens_hsa005001.34035621
42Other glycan degradation_Homo sapiens_hsa005111.31788352
43Sulfur relay system_Homo sapiens_hsa041221.31370963
44Sphingolipid metabolism_Homo sapiens_hsa006001.27893804
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22607071
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20088937
47Retinol metabolism_Homo sapiens_hsa008301.20045903
48Phenylalanine metabolism_Homo sapiens_hsa003601.16672392
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.15778506
50Arginine and proline metabolism_Homo sapiens_hsa003301.13807522
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13214055
52ABC transporters_Homo sapiens_hsa020101.13120712
53Pertussis_Homo sapiens_hsa051331.12462775
54Tyrosine metabolism_Homo sapiens_hsa003501.11361225
55Carbon metabolism_Homo sapiens_hsa012001.10680783
56Staphylococcus aureus infection_Homo sapiens_hsa051501.05332153
57Biosynthesis of amino acids_Homo sapiens_hsa012301.05058477
58Phagosome_Homo sapiens_hsa041451.02781559
59Bile secretion_Homo sapiens_hsa049761.02269788
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01143308
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00299106
62Vitamin B6 metabolism_Homo sapiens_hsa007500.98034085
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97493115
64Glycerolipid metabolism_Homo sapiens_hsa005610.95593101
65Collecting duct acid secretion_Homo sapiens_hsa049660.95520669
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93646301
67Glutathione metabolism_Homo sapiens_hsa004800.92463100
68Vitamin digestion and absorption_Homo sapiens_hsa049770.87945129
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87571775
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86036760
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.84500803
72Pentose phosphate pathway_Homo sapiens_hsa000300.82561933
73Linoleic acid metabolism_Homo sapiens_hsa005910.82266503
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.82022843
75Mineral absorption_Homo sapiens_hsa049780.81459798
76N-Glycan biosynthesis_Homo sapiens_hsa005100.81264260
77Lysosome_Homo sapiens_hsa041420.75517129
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75029922
79Amoebiasis_Homo sapiens_hsa051460.74665164
80Metabolic pathways_Homo sapiens_hsa011000.68724536
81Fatty acid biosynthesis_Homo sapiens_hsa000610.64270365
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63430239
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62331243
84Asthma_Homo sapiens_hsa053100.61825319
85Galactose metabolism_Homo sapiens_hsa000520.61555003
86ECM-receptor interaction_Homo sapiens_hsa045120.59145670
87Tuberculosis_Homo sapiens_hsa051520.59117234
88Osteoclast differentiation_Homo sapiens_hsa043800.55816829
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.54812515
90Leishmaniasis_Homo sapiens_hsa051400.54463104
91Proteasome_Homo sapiens_hsa030500.53905029
92Toxoplasmosis_Homo sapiens_hsa051450.53767331
93Fructose and mannose metabolism_Homo sapiens_hsa000510.53578040
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52407275
95Type I diabetes mellitus_Homo sapiens_hsa049400.51863036
96Protein digestion and absorption_Homo sapiens_hsa049740.50290886
97Systemic lupus erythematosus_Homo sapiens_hsa053220.49570969
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48453139
99Malaria_Homo sapiens_hsa051440.48438892
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47050288
101Salmonella infection_Homo sapiens_hsa051320.46625272
102Renin-angiotensin system_Homo sapiens_hsa046140.46048372
103Legionellosis_Homo sapiens_hsa051340.43734059
104Bladder cancer_Homo sapiens_hsa052190.43579290
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.42442040
106Prion diseases_Homo sapiens_hsa050200.42333664
107Arachidonic acid metabolism_Homo sapiens_hsa005900.41830744
108Pancreatic secretion_Homo sapiens_hsa049720.39953347
109TNF signaling pathway_Homo sapiens_hsa046680.39547912
110Hepatitis C_Homo sapiens_hsa051600.38674603
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37821952
112Autoimmune thyroid disease_Homo sapiens_hsa053200.36610160
113Pyrimidine metabolism_Homo sapiens_hsa002400.35202886
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.34110173
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33369997
116Oxidative phosphorylation_Homo sapiens_hsa001900.32304458
117Vibrio cholerae infection_Homo sapiens_hsa051100.31519441
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.30307141
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.30283971
120Lysine degradation_Homo sapiens_hsa003100.30069518
121Insulin resistance_Homo sapiens_hsa049310.28362115
122Ether lipid metabolism_Homo sapiens_hsa005650.24311264
123Glucagon signaling pathway_Homo sapiens_hsa049220.18748813
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18315483
125Thyroid hormone synthesis_Homo sapiens_hsa049180.18075649
126One carbon pool by folate_Homo sapiens_hsa006700.17820675
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17814042
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.16266835
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09656282
130Regulation of autophagy_Homo sapiens_hsa041400.08168311

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