SIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of osteoblast proliferation (GO:0033689)9.33817778
2axonal fasciculation (GO:0007413)9.07613960
3substrate-independent telencephalic tangential interneuron migration (GO:0021843)9.04114589
4substrate-independent telencephalic tangential migration (GO:0021826)9.04114589
5forebrain neuron differentiation (GO:0021879)8.45730911
6presynaptic membrane organization (GO:0097090)8.28351343
7axon ensheathment in central nervous system (GO:0032291)8.27972047
8central nervous system myelination (GO:0022010)8.27972047
9neuronal ion channel clustering (GO:0045161)7.84981679
10neuron recognition (GO:0008038)6.43961888
11positive regulation of action potential (GO:0045760)5.65387459
12response to inactivity (GO:0014854)5.56289976
13negative regulation of catenin import into nucleus (GO:0035414)5.00198629
14protein localization to microtubule (GO:0035372)4.96882401
15regulation of glucokinase activity (GO:0033131)4.81621844
16regulation of hexokinase activity (GO:1903299)4.81621844
17protein polyglutamylation (GO:0018095)4.70014352
18regulation of type B pancreatic cell apoptotic process (GO:2000674)4.67535157
19positive regulation of synapse assembly (GO:0051965)4.49765951
20regulation of male gonad development (GO:2000018)4.46873436
21semaphorin-plexin signaling pathway (GO:0071526)4.45863592
22cerebellar Purkinje cell differentiation (GO:0021702)4.43866706
23response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.43840205
24positive regulation of male gonad development (GO:2000020)4.38761794
25positive regulation of amino acid transport (GO:0051957)4.38402922
26pyrimidine nucleobase catabolic process (GO:0006208)4.14935629
27positive regulation of gastrulation (GO:2000543)4.07788062
28axoneme assembly (GO:0035082)4.02211270
29sodium ion export (GO:0071436)4.00754236
30prenylation (GO:0097354)3.88809625
31protein prenylation (GO:0018342)3.88809625
32positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.87949608
33magnesium ion transport (GO:0015693)3.83483908
34response to acidic pH (GO:0010447)3.83288978
35negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.77557084
36neuron cell-cell adhesion (GO:0007158)3.70846553
37positive regulation of glycolytic process (GO:0045821)3.66666368
38regulation of synapse assembly (GO:0051963)3.66596854
39macroautophagy (GO:0016236)3.60558958
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.59826278
41regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.48401976
42regulation of mesenchymal cell apoptotic process (GO:2001053)3.47444717
43actin-myosin filament sliding (GO:0033275)3.38085915
44muscle filament sliding (GO:0030049)3.38085915
45cilium movement (GO:0003341)3.37060604
46spinal cord association neuron differentiation (GO:0021527)3.36510947
47regulation of skeletal muscle contraction (GO:0014819)3.34197946
48layer formation in cerebral cortex (GO:0021819)3.30570437
49actin-mediated cell contraction (GO:0070252)3.27664546
50metanephric tubule development (GO:0072170)3.27608866
51metanephric nephron tubule development (GO:0072234)3.27608866
52cell volume homeostasis (GO:0006884)3.24286012
53neuron fate specification (GO:0048665)3.22351916
54positive regulation of meiosis (GO:0045836)3.18940949
55metanephric mesenchyme development (GO:0072075)3.18684665
56regulation of osteoblast proliferation (GO:0033688)3.18029770
57positive regulation of cell cycle checkpoint (GO:1901978)3.17730161
58protein K11-linked deubiquitination (GO:0035871)3.17316661
59cellular ketone body metabolic process (GO:0046950)3.16918505
60regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.16691146
61nuclear pore complex assembly (GO:0051292)3.14180939
62plasma membrane repair (GO:0001778)3.13991518
63cell proliferation in forebrain (GO:0021846)3.12781267
64epithelial cilium movement (GO:0003351)3.12726565
65regulation of astrocyte differentiation (GO:0048710)3.12439501
66endocrine pancreas development (GO:0031018)3.12286502
67myofibril assembly (GO:0030239)3.09952784
68regulation of neuronal synaptic plasticity (GO:0048168)3.08388314
69nucleobase catabolic process (GO:0046113)3.03851465
70nitric oxide mediated signal transduction (GO:0007263)3.00479268
71regulation of energy homeostasis (GO:2000505)2.99136933
72male sex determination (GO:0030238)2.98887187
73cellular response to pH (GO:0071467)2.98492578
74telencephalon cell migration (GO:0022029)2.98401221
75regulation of action potential (GO:0098900)2.96068336
76insulin secretion (GO:0030073)2.95314259
77glycerophospholipid catabolic process (GO:0046475)2.95013427
78kidney mesenchyme development (GO:0072074)2.94800312
79positive regulation of meiotic cell cycle (GO:0051446)2.92524088
80protein localization to microtubule cytoskeleton (GO:0072698)2.86958081
81positive regulation of embryonic development (GO:0040019)2.86568058
82positive regulation of synapse maturation (GO:0090129)2.85392506
83lymphangiogenesis (GO:0001946)2.84664612
84dendritic spine morphogenesis (GO:0060997)2.84149088
85nodal signaling pathway (GO:0038092)2.83554720
86positive regulation of insulin secretion (GO:0032024)2.81838909
87ketone body metabolic process (GO:1902224)2.81445697
88positive regulation of amine transport (GO:0051954)2.80755283
89regulation of transmission of nerve impulse (GO:0051969)2.80670860
90forebrain cell migration (GO:0021885)2.79646235
91regulation of synapse organization (GO:0050807)2.78122682
92primitive streak formation (GO:0090009)2.78103112
93regulation of synapse maturation (GO:0090128)2.76334095
94neuron migration (GO:0001764)2.76324270
95metanephric nephron epithelium development (GO:0072243)2.76309775
96glandular epithelial cell development (GO:0002068)2.75816435
97regulation of organ formation (GO:0003156)2.75353686
98somite rostral/caudal axis specification (GO:0032525)2.74793196
99cell migration in hindbrain (GO:0021535)2.74113053
100retinal cone cell development (GO:0046549)2.73809362
101cardiac myofibril assembly (GO:0055003)2.72959196
102adult feeding behavior (GO:0008343)2.72117251
103metanephric epithelium development (GO:0072207)2.71472349
104peristalsis (GO:0030432)2.70951932
105histone H3-K36 demethylation (GO:0070544)2.70542348
106negative regulation of JUN kinase activity (GO:0043508)2.69251227
107aggressive behavior (GO:0002118)2.67815323
108organic cation transport (GO:0015695)2.65380391
109diaphragm development (GO:0060539)2.64986627
110glandular epithelial cell differentiation (GO:0002067)2.64977107
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.64670186
112signal transduction involved in regulation of gene expression (GO:0023019)2.63453276
113suckling behavior (GO:0001967)2.63217964
114cerebellum development (GO:0021549)2.62790305
115positive regulation of organic acid transport (GO:0032892)2.58549466
116negative regulation of multicellular organism growth (GO:0040015)2.57027625
117inositol phosphate catabolic process (GO:0071545)2.55757908
118renal tubule development (GO:0061326)2.55306083
119cell differentiation in hindbrain (GO:0021533)2.55145486
120dopaminergic neuron differentiation (GO:0071542)2.54871373
121peptide hormone processing (GO:0016486)2.53230332
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.51838491
123protein-cofactor linkage (GO:0018065)2.51408030
124skeletal muscle organ development (GO:0060538)2.50590527
125smooth muscle tissue development (GO:0048745)2.49021238
126regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.47995355
127mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.47227969
128righting reflex (GO:0060013)2.46974052
129embryonic forelimb morphogenesis (GO:0035115)2.46596711
130opioid receptor signaling pathway (GO:0038003)2.46409032
131negative regulation of transcription by competitive promoter binding (GO:0010944)2.46357628
132COPI coating of Golgi vesicle (GO:0048205)2.45688173
133Golgi transport vesicle coating (GO:0048200)2.45688173
134drinking behavior (GO:0042756)2.45364374
135midbrain development (GO:0030901)2.44917404
136dorsal/ventral neural tube patterning (GO:0021904)2.44438995
137synaptic vesicle endocytosis (GO:0048488)2.43792720
138type B pancreatic cell development (GO:0003323)2.43300434
139negative regulation of axon extension involved in axon guidance (GO:0048843)2.42317563
140chemosensory behavior (GO:0007635)2.42204767
141regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.42017961
142regulation of uterine smooth muscle contraction (GO:0070472)2.40970833
143paraxial mesoderm development (GO:0048339)2.40915401
144regulation of p38MAPK cascade (GO:1900744)2.40914564
145central nervous system neuron development (GO:0021954)2.40470978
146protein K6-linked ubiquitination (GO:0085020)2.40027410
147polyol catabolic process (GO:0046174)2.39481085
148establishment of protein localization to Golgi (GO:0072600)2.39472156
149negative regulation of axon guidance (GO:1902668)2.39311424
150adult walking behavior (GO:0007628)2.39161264
151astrocyte differentiation (GO:0048708)2.39064856
152protein localization to cytoskeleton (GO:0044380)2.38698863
153phosphorylated carbohydrate dephosphorylation (GO:0046838)2.38591599
154inositol phosphate dephosphorylation (GO:0046855)2.38591599
155positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.38586013
156regulation of neurotransmitter uptake (GO:0051580)2.38302655
157retinal ganglion cell axon guidance (GO:0031290)2.38267918
158behavioral response to nicotine (GO:0035095)2.38224179
159positive regulation of mitochondrial membrane permeability (GO:0035794)2.38027909
160hippocampus development (GO:0021766)2.38027650
161positive regulation of uterine smooth muscle contraction (GO:0070474)2.37653593
162positive regulation of catecholamine secretion (GO:0033605)2.37607278
163tonic smooth muscle contraction (GO:0014820)2.37365417
164regulation of axonogenesis (GO:0050770)2.35689114
165nephron tubule development (GO:0072080)2.35502893
166endocardial cushion development (GO:0003197)2.34940450
167calcium ion import (GO:0070509)2.34802181
168positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.34214793
169positive regulation of protein autophosphorylation (GO:0031954)2.33110193
170excretion (GO:0007588)2.32934811
171forelimb morphogenesis (GO:0035136)2.31299013
172actin filament depolymerization (GO:0030042)2.31074301
173renal tubule morphogenesis (GO:0061333)2.30605232
174acrosome reaction (GO:0007340)2.30308015
175regulation of cardioblast proliferation (GO:0003264)2.29823493
176regulation of secondary heart field cardioblast proliferation (GO:0003266)2.29823493
177Golgi to endosome transport (GO:0006895)2.28922626
178actomyosin structure organization (GO:0031032)2.28300035
179anterior/posterior axis specification, embryo (GO:0008595)2.27953906
180artery development (GO:0060840)2.27716034
181sarcomere organization (GO:0045214)2.27167262
182hematopoietic stem cell proliferation (GO:0071425)2.24715005
183protein targeting to Golgi (GO:0000042)2.21517724
184nephron tubule morphogenesis (GO:0072078)2.21409740
185nephron epithelium morphogenesis (GO:0072088)2.21409740
186regulation of sarcomere organization (GO:0060297)2.21314635
187regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.21211628
188regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.21211628
189activin receptor signaling pathway (GO:0032924)2.21183944
190hindbrain development (GO:0030902)2.21127781
191inner ear receptor cell development (GO:0060119)2.20977910
192positive regulation of peptide hormone secretion (GO:0090277)2.20183479
193response to pheromone (GO:0019236)10.1640597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human3.45173426
2CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.40554848
3EZH2_22144423_ChIP-Seq_EOC_Human3.28122669
4* BMI1_23680149_ChIP-Seq_NPCS_Mouse3.26131752
5* EZH2_27304074_Chip-Seq_ESCs_Mouse3.14231024
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81256845
7* EED_16625203_ChIP-ChIP_MESCs_Mouse2.79202451
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70035259
9GBX2_23144817_ChIP-Seq_PC3_Human2.66016621
10* RNF2_27304074_Chip-Seq_ESCs_Mouse2.63744753
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.58444687
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51136040
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49850612
14* CBX2_27304074_Chip-Seq_ESCs_Mouse2.48915018
15* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43942415
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.36667737
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34904716
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29879176
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.28884079
20* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21167438
21* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21167438
22* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.16437385
23REST_21632747_ChIP-Seq_MESCs_Mouse2.15140898
24* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15117098
25TAF15_26573619_Chip-Seq_HEK293_Human2.13560337
26* RNF2_27304074_Chip-Seq_NSC_Mouse2.05967244
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01528765
28ZNF274_21170338_ChIP-Seq_K562_Hela1.99230889
29FUS_26573619_Chip-Seq_HEK293_Human1.98362723
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97227839
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.95482507
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93541635
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92235456
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89579051
35AR_21572438_ChIP-Seq_LNCaP_Human1.76673292
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76619122
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76520206
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.74468191
39OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.72186312
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72132850
41* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67047263
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65357758
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64691067
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.63664477
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58238255
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56522391
47AR_25329375_ChIP-Seq_VCAP_Human1.55982748
48BCAT_22108803_ChIP-Seq_LS180_Human1.55023704
49EWS_26573619_Chip-Seq_HEK293_Human1.53936524
50* RING1B_27294783_Chip-Seq_ESCs_Mouse1.51230492
51SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51212283
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50818485
53* P300_19829295_ChIP-Seq_ESCs_Human1.50255671
54CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49435171
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47695204
56NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46166221
57* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43316125
58STAT3_23295773_ChIP-Seq_U87_Human1.40905267
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.39913347
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39662153
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.39108998
62DROSHA_22980978_ChIP-Seq_HELA_Human1.37482372
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37033748
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.35826483
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35718698
66RXR_22108803_ChIP-Seq_LS180_Human1.35171654
67CJUN_26792858_Chip-Seq_BT549_Human1.34764053
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34673288
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34238733
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.32506564
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31115735
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30461665
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29275320
74* TCF4_23295773_ChIP-Seq_U87_Human1.28145172
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.28092589
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27860430
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27100194
78* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.25921352
79* SMAD4_21799915_ChIP-Seq_A2780_Human1.25501788
80* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23659266
81* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23659266
82* RING1B_27294783_Chip-Seq_NPCs_Mouse1.23630690
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.23525337
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22854435
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22443819
86CBP_20019798_ChIP-Seq_JUKART_Human1.22443819
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21622216
88RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20751446
89* TP53_20018659_ChIP-ChIP_R1E_Mouse1.19140354
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19073452
91HTT_18923047_ChIP-ChIP_STHdh_Human1.18529327
92TBL1_22424771_ChIP-Seq_293T_Human1.17376827
93TP53_18474530_ChIP-ChIP_U2OS_Human1.17366947
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17089503
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15906658
96* CRX_20693478_ChIP-Seq_RETINA_Mouse1.15590253
97CDX2_22108803_ChIP-Seq_LS180_Human1.14690888
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14434121
99TCF4_22108803_ChIP-Seq_LS180_Human1.14111725
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.13169933
101* BRD4_25478319_ChIP-Seq_HGPS_Human1.12956828
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12479454
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11545627
104POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11370233
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11370233
106* RUNX2_22187159_ChIP-Seq_PCA_Human1.10887680
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10816055
108* EZH2_27294783_Chip-Seq_NPCs_Mouse1.10550657
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.08789974
110* FLI1_21867929_ChIP-Seq_TH2_Mouse1.08460090
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08436870
112* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08176539
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07614370
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06033545
115* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05310762
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04741856
117* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04363026
118POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03890231
119VDR_22108803_ChIP-Seq_LS180_Human1.03723017
120P53_22387025_ChIP-Seq_ESCs_Mouse1.03155225
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.01955986
122NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01251699
123* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99776823
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99331949
125RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99307958
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99285433
127RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98943820
128SOX2_21211035_ChIP-Seq_LN229_Gbm0.98325782
129CMYC_18555785_Chip-Seq_ESCs_Mouse0.97702872
130TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.96897254
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.96881892
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.95664689
133ESRRB_18555785_Chip-Seq_ESCs_Mouse0.93608173
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93590566
135ER_23166858_ChIP-Seq_MCF-7_Human0.92137463
136CTCF_18555785_Chip-Seq_ESCs_Mouse0.91369977
137OCT4_18555785_Chip-Seq_ESCs_Mouse0.91193525
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.90496970
139E2F1_18555785_Chip-Seq_ESCs_Mouse0.89440039
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89078989
141* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88739272
142KLF4_18555785_Chip-Seq_ESCs_Mouse0.88416489
143* AR_19668381_ChIP-Seq_PC3_Human0.87299177
144* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86894688
145MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85683212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous7.58719896
2MP0005645_abnormal_hypothalamus_physiol5.99406101
3MP0008995_early_reproductive_senescence5.07815879
4MP0003122_maternal_imprinting4.88996231
5MP0003183_abnormal_peptide_metabolism4.60106316
6MP0005503_abnormal_tendon_morphology3.23857991
7MP0006276_abnormal_autonomic_nervous2.89910965
8MP0002653_abnormal_ependyma_morphology2.81712249
9MP0005646_abnormal_pituitary_gland2.67074959
10MP0003646_muscle_fatigue2.55055189
11MP0003121_genomic_imprinting2.40655456
12MP0003172_abnormal_lysosome_physiology2.37265374
13MP0008438_abnormal_cutaneous_collagen2.37066959
14MP0010030_abnormal_orbit_morphology2.20400332
15MP0002928_abnormal_bile_duct2.17649753
16MP0002108_abnormal_muscle_morphology2.15201422
17* MP0000778_abnormal_nervous_system2.07252807
18MP0000538_abnormal_urinary_bladder2.06167692
19MP0002234_abnormal_pharynx_morphology2.04723890
20MP0001502_abnormal_circadian_rhythm1.93806972
21MP0000749_muscle_degeneration1.93045244
22MP0000751_myopathy1.90772591
23MP0008961_abnormal_basal_metabolism1.89883802
24MP0003880_abnormal_central_pattern1.89777192
25MP0002733_abnormal_thermal_nociception1.88271512
26MP0002909_abnormal_adrenal_gland1.78770525
27MP0008877_abnormal_DNA_methylation1.78753923
28MP0009384_cardiac_valve_regurgitation1.76604434
29MP0003283_abnormal_digestive_organ1.75927637
30MP0001958_emphysema1.74255085
31MP0004859_abnormal_synaptic_plasticity1.66844319
32MP0002751_abnormal_autonomic_nervous1.59872275
33MP0001346_abnormal_lacrimal_gland1.56420457
34MP0001486_abnormal_startle_reflex1.55347511
35MP0002184_abnormal_innervation1.54854365
36MP0004036_abnormal_muscle_relaxation1.50273069
37MP0001984_abnormal_olfaction1.49768430
38MP0010386_abnormal_urinary_bladder1.48316572
39MP0004043_abnormal_pH_regulation1.47826052
40* MP0000631_abnormal_neuroendocrine_gland1.47048435
41MP0002160_abnormal_reproductive_system1.45376380
42MP0003195_calcinosis1.45307404
43MP0004215_abnormal_myocardial_fiber1.43332506
44MP0005369_muscle_phenotype1.42937998
45MP0002063_abnormal_learning/memory/cond1.41110535
46MP0001440_abnormal_grooming_behavior1.40666245
47MP0002282_abnormal_trachea_morphology1.39265919
48MP0001529_abnormal_vocalization1.38519264
49MP0001970_abnormal_pain_threshold1.36156651
50MP0002254_reproductive_system_inflammat1.35569320
51MP0003950_abnormal_plasma_membrane1.35371477
52MP0003252_abnormal_bile_duct1.33325956
53MP0003786_premature_aging1.31444426
54MP0003045_fibrosis1.28539702
55MP0004270_analgesia1.27190552
56MP0005275_abnormal_skin_tensile1.26857615
57MP0002572_abnormal_emotion/affect_behav1.24623331
58MP0004134_abnormal_chest_morphology1.23565873
59MP0002139_abnormal_hepatobiliary_system1.23298810
60MP0002106_abnormal_muscle_physiology1.23118915
61MP0005620_abnormal_muscle_contractility1.22706887
62MP0002638_abnormal_pupillary_reflex1.22089217
63MP0001944_abnormal_pancreas_morphology1.21507776
64MP0002064_seizures1.21442019
65MP0000955_abnormal_spinal_cord1.20384483
66MP0004272_abnormal_basement_membrane1.19570925
67MP0005379_endocrine/exocrine_gland_phen1.16927567
68MP0003942_abnormal_urinary_system1.16917588
69MP0006054_spinal_hemorrhage1.16454455
70MP0001299_abnormal_eye_distance/1.15606398
71* MP0003635_abnormal_synaptic_transmissio1.15439900
72MP0005084_abnormal_gallbladder_morpholo1.15242262
73MP0000013_abnormal_adipose_tissue1.12133720
74MP0002557_abnormal_social/conspecific_i1.12023757
75MP0004133_heterotaxia1.11672831
76MP0002168_other_aberrant_phenotype1.11354197
77MP0001270_distended_abdomen1.10456561
78MP0009745_abnormal_behavioral_response1.09939921
79MP0000462_abnormal_digestive_system1.09720489
80MP0005257_abnormal_intraocular_pressure1.09455361
81MP0002163_abnormal_gland_morphology1.08932064
82MP0002295_abnormal_pulmonary_circulatio1.08672680
83MP0003137_abnormal_impulse_conducting1.07957479
84MP0005248_abnormal_Harderian_gland1.06013431
85MP0005389_reproductive_system_phenotype1.05450879
86MP0005332_abnormal_amino_acid1.05133191
87MP0002876_abnormal_thyroid_physiology1.04927739
88MP0009046_muscle_twitch1.04123801
89MP0000230_abnormal_systemic_arterial1.03847100
90MP0004885_abnormal_endolymph1.03613064
91MP0003279_aneurysm1.03530868
92MP0000003_abnormal_adipose_tissue1.03138044
93MP0005551_abnormal_eye_electrophysiolog1.02318715
94MP0001542_abnormal_bone_strength1.02314135
95MP0004145_abnormal_muscle_electrophysio1.01846961
96MP0000759_abnormal_skeletal_muscle1.01422393
97MP0002269_muscular_atrophy1.01283420
98MP0004019_abnormal_vitamin_homeostasis1.01030333
99MP0004084_abnormal_cardiac_muscle1.00595518
100MP0001727_abnormal_embryo_implantation0.99946266
101MP0004142_abnormal_muscle_tone0.99206425
102MP0001501_abnormal_sleep_pattern0.98763511
103MP0002734_abnormal_mechanical_nocicepti0.98096703
104MP0002693_abnormal_pancreas_physiology0.97546492
105MP0003787_abnormal_imprinting0.97322516
106MP0005187_abnormal_penis_morphology0.97184406
107MP0005253_abnormal_eye_physiology0.96541808
108MP0002837_dystrophic_cardiac_calcinosis0.94154747
109MP0000026_abnormal_inner_ear0.92861051
110* MP0002971_abnormal_brown_adipose0.91037275
111* MP0002882_abnormal_neuron_morphology0.88728891
112MP0004130_abnormal_muscle_cell0.87819761
113MP0001756_abnormal_urination0.85368176
114MP0001765_abnormal_ion_homeostasis0.84678255
115MP0002938_white_spotting0.84019859
116MP0002735_abnormal_chemical_nociception0.83058335
117MP0003315_abnormal_perineum_morphology0.82950946
118MP0005310_abnormal_salivary_gland0.82849656
119MP0001661_extended_life_span0.82439785
120MP0006072_abnormal_retinal_apoptosis0.81984053
121MP0004087_abnormal_muscle_fiber0.81647508
122MP0000427_abnormal_hair_cycle0.81421648
123* MP0002069_abnormal_eating/drinking_beha0.81213184
124MP0005220_abnormal_exocrine_pancreas0.81164219
125MP0000569_abnormal_digit_pigmentation0.80091405
126MP0004085_abnormal_heartbeat0.76926852
127* MP0004811_abnormal_neuron_physiology0.76673330
128MP0009250_abnormal_appendicular_skeleto0.76494393
129MP0002272_abnormal_nervous_system0.76123552
130MP0002277_abnormal_respiratory_mucosa0.76090163
131MP0004510_myositis0.74134213
132MP0001348_abnormal_lacrimal_gland0.74019302
133MP0002102_abnormal_ear_morphology0.73955603
134MP0000750_abnormal_muscle_regeneration0.73784194
135MP0003959_abnormal_lean_body0.73233955
136* MP0009643_abnormal_urine_homeostasis0.72969096
137MP0003119_abnormal_digestive_system0.72550794
138MP0000747_muscle_weakness0.72203433
139* MP0002066_abnormal_motor_capabilities/c0.71518267
140MP0002138_abnormal_hepatobiliary_system0.71161924
141MP0001986_abnormal_taste_sensitivity0.69899564
142MP0004742_abnormal_vestibular_system0.67955371
143MP0002752_abnormal_somatic_nervous0.66723399
144MP0002067_abnormal_sensory_capabilities0.65871675
145* MP0002078_abnormal_glucose_homeostasis0.65621622
146MP0001968_abnormal_touch/_nociception0.65223424
147MP0000678_abnormal_parathyroid_gland0.64763609
148MP0000534_abnormal_ureter_morphology0.64638463
149MP0005535_abnormal_body_temperature0.64464147
150* MP0003953_abnormal_hormone_level0.63029351
151* MP0002152_abnormal_brain_morphology0.62241801
152MP0009780_abnormal_chondrocyte_physiolo0.61853853
153MP0006292_abnormal_olfactory_placode0.61670824
154MP0001188_hyperpigmentation0.58747346
155MP0005386_behavior/neurological_phenoty0.58183847
156MP0004924_abnormal_behavior0.58183847
157MP0001963_abnormal_hearing_physiology0.56761878
158MP0003861_abnormal_nervous_system0.52763718
159MP0005636_abnormal_mineral_homeostasis0.51641387

Predicted human phenotypes

RankGene SetZ-score
1Failure to thrive in infancy (HP:0001531)5.38814673
2High anterior hairline (HP:0009890)5.33820295
3Sex reversal (HP:0012245)5.24957315
4Abnormal sex determination (HP:0012244)5.24957315
5Osteomalacia (HP:0002749)4.93938198
6Polyphagia (HP:0002591)4.85329850
7Nemaline bodies (HP:0003798)4.85155200
8Muscle fiber inclusion bodies (HP:0100299)4.77347079
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.71800123
10Hyperaldosteronism (HP:0000859)4.59431348
11Abnormality of calcium-phosphate metabolism (HP:0100530)4.46758466
12Type 1 muscle fiber predominance (HP:0003803)4.35094822
13Amaurosis fugax (HP:0100576)4.16306799
14Calf muscle hypertrophy (HP:0008981)3.87055813
15Hypokalemia (HP:0002900)3.85723852
16Metabolic alkalosis (HP:0200114)3.85299964
17Proximal tubulopathy (HP:0000114)3.78585177
18Increased circulating renin level (HP:0000848)3.74802962
19Muscle hypertrophy of the lower extremities (HP:0008968)3.73939768
20Atelectasis (HP:0100750)3.72518302
21Sleep apnea (HP:0010535)3.70837908
22Hyperactive renin-angiotensin system (HP:0000841)3.43020378
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.38013649
24Hypokalemic alkalosis (HP:0001949)3.28187239
25Esotropia (HP:0000565)3.27407636
26Hypomagnesemia (HP:0002917)3.25486072
27Renal Fanconi syndrome (HP:0001994)3.23758509
28Polyuria (HP:0000103)3.22136827
29Abnormality of proline metabolism (HP:0010907)3.19975206
30Hydroxyprolinuria (HP:0003080)3.19975206
31Hypercalciuria (HP:0002150)3.19951378
32Abnormality of renin-angiotensin system (HP:0000847)3.16442335
33True hermaphroditism (HP:0010459)3.12366778
34Abnormality of potassium homeostasis (HP:0011042)3.00781632
35Abnormal ciliary motility (HP:0012262)3.00435773
36Abnormal urine output (HP:0012590)2.98058189
37Cardiovascular calcification (HP:0011915)2.94940266
38Thyroid-stimulating hormone excess (HP:0002925)2.90707306
39Abnormality of the calf musculature (HP:0001430)2.88813260
40Vitreoretinal degeneration (HP:0000655)2.86303046
41Abnormality of sodium homeostasis (HP:0010931)2.85902397
42Hyponatremia (HP:0002902)2.83713237
43Abnormality of renal resorption (HP:0011038)2.81494613
44Vascular calcification (HP:0004934)2.81268604
45Abnormality of chloride homeostasis (HP:0011422)2.79436096
46Hyperinsulinemic hypoglycemia (HP:0000825)2.77011359
47Decreased circulating renin level (HP:0003351)2.75337475
48Abnormal drinking behavior (HP:0030082)2.73021786
49Polydipsia (HP:0001959)2.73021786
50Abnormality of renal excretion (HP:0011036)2.70405413
51Large for gestational age (HP:0001520)2.70161189
52Hyperglycemia (HP:0003074)2.69670772
53Hyperphosphaturia (HP:0003109)2.69644032
54Gout (HP:0001997)2.65783934
55* Abnormal eating behavior (HP:0100738)2.65592778
56Nephrocalcinosis (HP:0000121)2.63880661
57Exercise-induced muscle cramps (HP:0003710)2.61099352
58Fetal akinesia sequence (HP:0001989)2.58268017
59Tetany (HP:0001281)2.57583250
60Abnormality of magnesium homeostasis (HP:0004921)2.54853402
61Tubular atrophy (HP:0000092)2.54824521
62Exotropia (HP:0000577)2.52180419
63Exercise-induced myalgia (HP:0003738)2.45594331
64Renal tubular acidosis (HP:0001947)2.45220295
65Round ear (HP:0100830)2.43823671
66Distal arthrogryposis (HP:0005684)2.41687090
67Skin nodule (HP:0200036)2.41644301
68Renal salt wasting (HP:0000127)2.40958499
69Type II lissencephaly (HP:0007260)2.40674768
70Abnormal pancreas size (HP:0012094)2.40417209
71Wrist flexion contracture (HP:0001239)2.38424273
72Insulin-resistant diabetes mellitus (HP:0000831)2.36341800
73Abnormal urine phosphate concentration (HP:0012599)2.35340630
74Hypoglycemic seizures (HP:0002173)2.33483044
75Testicular neoplasm (HP:0010788)2.31598594
76Absent phalangeal crease (HP:0006109)2.28637642
77Adrenal overactivity (HP:0002717)2.27215747
78Aplasia of the musculature (HP:0100854)2.26658115
79Hypophosphatemia (HP:0002148)2.21958941
80Mesomelia (HP:0003027)2.21127653
81Poor suck (HP:0002033)2.20554126
82Abnormal hair whorl (HP:0010721)2.19839713
83Hyperparathyroidism (HP:0000843)2.19796876
84Patellar dislocation (HP:0002999)2.17687631
85Late onset (HP:0003584)2.16313379
86Hyperthyroidism (HP:0000836)2.16204297
87Popliteal pterygium (HP:0009756)2.15377722
88Hypoplastic ischia (HP:0003175)2.14859681
89Symptomatic seizures (HP:0011145)2.13500836
90Abnormality of dentin (HP:0010299)2.12656444
91Widely patent fontanelles and sutures (HP:0004492)2.12459610
92Pancreatic cysts (HP:0001737)2.12118766
93Alkalosis (HP:0001948)2.11664885
94Enlarged penis (HP:0000040)2.08979481
95Abnormality of urine glucose concentration (HP:0011016)2.08640615
96Glycosuria (HP:0003076)2.08640615
97Buphthalmos (HP:0000557)2.08095936
98Abnormality of the renal cortex (HP:0011035)2.06926993
99Hip contracture (HP:0003273)2.06742222
100Broad-based gait (HP:0002136)2.06249535
101Frequent falls (HP:0002359)2.05157481
102Rimmed vacuoles (HP:0003805)2.04730995
103Agitation (HP:0000713)2.04660105
104Abnormal respiratory motile cilium physiology (HP:0012261)2.03993372
105Hypothermia (HP:0002045)2.03540038
106Abnormality of the renal medulla (HP:0100957)2.03066882
107Delayed gross motor development (HP:0002194)2.02360850
108Abnormal finger flexion creases (HP:0006143)2.02194603
109Hyperuricemia (HP:0002149)2.00812342
110Increased purine levels (HP:0004368)2.00812342
111Abnormality of the pancreatic islet cells (HP:0006476)2.00300153
112Abnormality of endocrine pancreas physiology (HP:0012093)2.00300153
113Cheilitis (HP:0100825)1.99933524
114Ulnar deviation of the wrist (HP:0003049)1.99896922
115Ketoacidosis (HP:0001993)1.99836243
116Ketosis (HP:0001946)1.98213842
117Hip dysplasia (HP:0001385)1.97290308
118Deformed tarsal bones (HP:0008119)1.96590011
119Nephronophthisis (HP:0000090)1.93735265
120Renal duplication (HP:0000075)1.93213405
121Open mouth (HP:0000194)1.93075659
122Exocrine pancreatic insufficiency (HP:0001738)1.93005629
123Intestinal atresia (HP:0011100)1.92050303
124EMG: myopathic abnormalities (HP:0003458)1.91256141
125Congenital sensorineural hearing impairment (HP:0008527)1.90569393
126Elfin facies (HP:0004428)1.89896329
127Pendular nystagmus (HP:0012043)1.88950938
128Prominent supraorbital ridges (HP:0000336)1.88033236
129Abnormality of glutamine family amino acid metabolism (HP:0010902)1.87758034
130Hypoglycemic coma (HP:0001325)1.86713321
131Oligomenorrhea (HP:0000876)1.86060315
132Myopathic facies (HP:0002058)1.85556021
133Unilateral renal agenesis (HP:0000122)1.83689051
134Anteriorly placed anus (HP:0001545)1.83159506
135Congenital stationary night blindness (HP:0007642)1.82402781
136Tetraparesis (HP:0002273)1.82236315
137Downturned corners of mouth (HP:0002714)1.81193104
138Conjugated hyperbilirubinemia (HP:0002908)1.80947272
139Soft skin (HP:0000977)1.80714493
140Gingivitis (HP:0000230)1.80535047
141Pancreatic islet-cell hyperplasia (HP:0004510)1.79969409
142Generalized muscle weakness (HP:0003324)1.79601183
143Limited hip movement (HP:0008800)1.78846379
144Congenital glaucoma (HP:0001087)1.78805893
145Pancreatic fibrosis (HP:0100732)1.78524568
146Blue irides (HP:0000635)1.77899828
147Wide cranial sutures (HP:0010537)1.77807509
148Hyperphosphatemia (HP:0002905)1.76735807
149Protruding tongue (HP:0010808)1.76168171
150Febrile seizures (HP:0002373)1.75902296
151Abnormality of the dental pulp (HP:0006479)1.74740712
152Rickets (HP:0002748)1.74654976
153Hypoalbuminemia (HP:0003073)1.74055427
154Abnormal albumin level (HP:0012116)1.74055427
155Papilledema (HP:0001085)1.73524516
156Slender build (HP:0001533)1.72459497
157Abnormality of the ischium (HP:0003174)1.71419123
158Abnormality of midbrain morphology (HP:0002418)1.70181267
159Molar tooth sign on MRI (HP:0002419)1.70181267
160Abnormality of purine metabolism (HP:0004352)1.69937305
161Hypoplasia of the fovea (HP:0007750)1.69577530
162Aplasia/Hypoplasia of the fovea (HP:0008060)1.69577530
163Calcaneovalgus deformity (HP:0001848)1.65670015
164Myoglobinuria (HP:0002913)1.65650914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA39.72058380
2WNK34.49828432
3IRAK23.23139979
4IRAK42.90401928
5BRD42.90353364
6PHKG12.82499058
7PHKG22.82499058
8MAPK152.63626694
9IRAK12.42089914
10ERBB22.32844969
11SIK32.30222816
12AKT32.26988057
13NTRK32.26058825
14PINK12.25767826
15RIPK12.05242579
16ACVR1B1.98540677
17GRK11.93708077
18WNK41.84519814
19UHMK11.80342598
20MYLK1.79009879
21INSRR1.71949182
22LIMK11.69776991
23NLK1.67365104
24STK38L1.62819414
25MARK11.62289410
26MAP3K131.61183423
27TRPM71.59162590
28KSR11.56562757
29PAK31.52413095
30PAK61.47751981
31BMPR1B1.42507068
32RPS6KA21.39077560
33MAPKAPK31.38051582
34CASK1.37218694
35MAP3K121.30936559
36OXSR11.30139114
37TTN1.29850783
38BRSK21.26169245
39FER1.23246803
40MAPK131.22915036
41PNCK1.20465067
42NTRK21.20423413
43EPHB21.20056360
44FRK1.18195799
45DAPK21.14902163
46FGFR21.14421107
47PTK2B1.10336345
48STK391.09822870
49DDR21.06857523
50MAP2K71.06398136
51LATS11.04266485
52PIK3CG1.03616680
53MAP3K71.01444370
54TNIK1.00813971
55SRPK10.99722243
56STK30.98536674
57PASK0.98521344
58MUSK0.91226191
59PRPF4B0.90964773
60MAP3K140.84864893
61TBK10.81114231
62PRKAA10.81046641
63FGFR30.80663767
64NEK90.80636924
65MAP3K40.79709752
66EEF2K0.79331998
67RPS6KL10.78858078
68RPS6KC10.78858078
69STK380.78844469
70MAP4K20.76119096
71SIK20.75909651
72STK110.71703588
73MST40.70914346
74SGK2230.70724594
75SGK4940.70724594
76PRKD20.68339415
77DYRK20.67850352
78KSR20.66425591
79CAMK2D0.65283299
80MAP3K20.64456144
81MAP3K90.64252907
82SGK20.61924467
83BCR0.61100781
84IKBKE0.60815533
85MAP2K40.60317481
86RPS6KA60.58341976
87HIPK20.57877743
88MAP2K60.57373938
89ERN10.54176145
90CAMK10.53553640
91PLK20.51759054
92STK160.50746370
93MAPK90.49281520
94CSNK1G10.48785638
95ROCK20.48228701
96MAP2K10.47529909
97SGK10.46529875
98CAMK2G0.45554756
99ROCK10.43993055
100CDK50.43802396
101ADRBK20.43404843
102MINK10.42424342
103NUAK10.42390027
104PRKCZ0.41567221
105BRSK10.41378514
106PRKG10.40719207
107MELK0.40211875
108PIK3CA0.38410110
109PRKCE0.37779582
110CAMK1D0.37640541
111EIF2AK30.37625491
112CAMK2B0.37361513
113CDK30.36867610
114ERBB30.36405331
115ADRBK10.35530434
116RPS6KA10.34932636
117TAOK30.34234302
118MAPK100.34213238
119DYRK1A0.33091794
120CSNK1A10.32220004
121MAPKAPK50.30877420
122MAPK70.30763985
123MKNK20.30401460
124CDC42BPA0.30187646
125PAK20.29995815
126OBSCN0.28864032
127GRK70.28632499
128PKN10.28572027
129PRKCH0.28336139
130GSK3A0.28225421
131SIK10.28195773
132TGFBR10.28067177
133PRKAA20.28052245
134PRKCG0.27538395
135EPHA20.27304341
136CDK80.26989130
137PRKACB0.25415683
138PRKACA0.25240080
139CAMK1G0.25009683
140VRK10.24990876
141PRKCD0.24667530
142CAMK2A0.24597274
143PRKACG0.23790766
144PTK20.23560112
145YES10.23472787
146CHUK0.23343981
147CAMKK20.23004250
148EIF2AK20.20841102
149PRKD30.20804585
150MARK20.19506340
151NME10.18749555
152CAMK40.18070085
153AKT10.17623180
154DYRK30.17535911
155SGK30.17494451
156PRKCA0.17271106

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.97039547
2Axon guidance_Homo sapiens_hsa043603.38816022
3Nicotine addiction_Homo sapiens_hsa050332.97681031
4Insulin secretion_Homo sapiens_hsa049112.61305038
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12197945
6Cardiac muscle contraction_Homo sapiens_hsa042602.03451486
7Protein export_Homo sapiens_hsa030601.98802117
8Type I diabetes mellitus_Homo sapiens_hsa049401.95391388
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.91007958
10GABAergic synapse_Homo sapiens_hsa047271.84801868
11Taste transduction_Homo sapiens_hsa047421.74479882
12Cocaine addiction_Homo sapiens_hsa050301.72985316
13Tryptophan metabolism_Homo sapiens_hsa003801.71932848
14Propanoate metabolism_Homo sapiens_hsa006401.69981213
15Circadian rhythm_Homo sapiens_hsa047101.66400535
16Oxidative phosphorylation_Homo sapiens_hsa001901.63822944
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63206534
18Circadian entrainment_Homo sapiens_hsa047131.62993243
19Regulation of autophagy_Homo sapiens_hsa041401.59248857
20Collecting duct acid secretion_Homo sapiens_hsa049661.58564608
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55392044
22Type II diabetes mellitus_Homo sapiens_hsa049301.54905874
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47078884
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46746596
25Selenocompound metabolism_Homo sapiens_hsa004501.46635321
26Vibrio cholerae infection_Homo sapiens_hsa051101.44841638
27Morphine addiction_Homo sapiens_hsa050321.41383032
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40628573
29Serotonergic synapse_Homo sapiens_hsa047261.39721187
30Synaptic vesicle cycle_Homo sapiens_hsa047211.39424549
31Amphetamine addiction_Homo sapiens_hsa050311.30405669
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25743985
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21534394
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.20677914
35N-Glycan biosynthesis_Homo sapiens_hsa005101.17807494
36Phototransduction_Homo sapiens_hsa047441.17071210
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15672267
38Alzheimers disease_Homo sapiens_hsa050101.12626302
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.12624625
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12054904
41Folate biosynthesis_Homo sapiens_hsa007901.11415940
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08945532
43Parkinsons disease_Homo sapiens_hsa050121.08572391
44Gastric acid secretion_Homo sapiens_hsa049711.04485881
45Fatty acid elongation_Homo sapiens_hsa000621.02422522
46Glutamatergic synapse_Homo sapiens_hsa047240.99860566
47Salivary secretion_Homo sapiens_hsa049700.99374883
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99094263
49Fatty acid degradation_Homo sapiens_hsa000710.98886164
50Dopaminergic synapse_Homo sapiens_hsa047280.98550014
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.98460444
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98025329
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96982501
54Prion diseases_Homo sapiens_hsa050200.96873432
55TGF-beta signaling pathway_Homo sapiens_hsa043500.96137196
56Olfactory transduction_Homo sapiens_hsa047400.95673329
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95368349
58Pancreatic secretion_Homo sapiens_hsa049720.94522092
59beta-Alanine metabolism_Homo sapiens_hsa004100.94284184
60Butanoate metabolism_Homo sapiens_hsa006500.93867864
61Huntingtons disease_Homo sapiens_hsa050160.91625856
62Basal cell carcinoma_Homo sapiens_hsa052170.88919893
63Dilated cardiomyopathy_Homo sapiens_hsa054140.87520524
64Renin secretion_Homo sapiens_hsa049240.86848732
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85656963
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84839403
67Starch and sucrose metabolism_Homo sapiens_hsa005000.83674085
68Long-term potentiation_Homo sapiens_hsa047200.81992014
69Inositol phosphate metabolism_Homo sapiens_hsa005620.80261623
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79976732
71Fatty acid metabolism_Homo sapiens_hsa012120.78607604
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78495149
73Phagosome_Homo sapiens_hsa041450.77505345
74Ovarian steroidogenesis_Homo sapiens_hsa049130.77466669
75Dorso-ventral axis formation_Homo sapiens_hsa043200.76075927
76Nitrogen metabolism_Homo sapiens_hsa009100.75705117
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74715947
78AMPK signaling pathway_Homo sapiens_hsa041520.74584343
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74128739
80Peroxisome_Homo sapiens_hsa041460.73839118
81ABC transporters_Homo sapiens_hsa020100.73612865
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71767074
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71046471
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69882325
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69020719
86Histidine metabolism_Homo sapiens_hsa003400.68213191
87cAMP signaling pathway_Homo sapiens_hsa040240.67924339
88Cholinergic synapse_Homo sapiens_hsa047250.67773766
89Arginine and proline metabolism_Homo sapiens_hsa003300.67615551
90Protein digestion and absorption_Homo sapiens_hsa049740.67453489
91Vitamin B6 metabolism_Homo sapiens_hsa007500.67284066
92Rheumatoid arthritis_Homo sapiens_hsa053230.66168830
93Oxytocin signaling pathway_Homo sapiens_hsa049210.63492694
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63163259
95Hedgehog signaling pathway_Homo sapiens_hsa043400.62760596
96Ether lipid metabolism_Homo sapiens_hsa005650.62237087
97Insulin resistance_Homo sapiens_hsa049310.61789857
98Bile secretion_Homo sapiens_hsa049760.60561485
99Sulfur metabolism_Homo sapiens_hsa009200.59367426
100Thyroid hormone synthesis_Homo sapiens_hsa049180.59113280
101Endometrial cancer_Homo sapiens_hsa052130.58920949
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58298971
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58047113
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57473613
105Gap junction_Homo sapiens_hsa045400.56875904
106Calcium signaling pathway_Homo sapiens_hsa040200.56792054
107Glucagon signaling pathway_Homo sapiens_hsa049220.55703454
108Wnt signaling pathway_Homo sapiens_hsa043100.55612196
109Glutathione metabolism_Homo sapiens_hsa004800.55549945
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.54977509
111Notch signaling pathway_Homo sapiens_hsa043300.54871035
112Sphingolipid metabolism_Homo sapiens_hsa006000.54489204
113Retinol metabolism_Homo sapiens_hsa008300.53187714
114Tight junction_Homo sapiens_hsa045300.52846062
115Melanogenesis_Homo sapiens_hsa049160.52271024
116Metabolic pathways_Homo sapiens_hsa011000.52163786
117Long-term depression_Homo sapiens_hsa047300.52023367
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51203497
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50813995
120ECM-receptor interaction_Homo sapiens_hsa045120.49560854
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49390490
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.49368238
123Vitamin digestion and absorption_Homo sapiens_hsa049770.48944797
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48613534
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48058938
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47098228
127Estrogen signaling pathway_Homo sapiens_hsa049150.42996326
128Linoleic acid metabolism_Homo sapiens_hsa005910.41776021
129Prolactin signaling pathway_Homo sapiens_hsa049170.40439251
130Lysosome_Homo sapiens_hsa041420.39806556
131ErbB signaling pathway_Homo sapiens_hsa040120.39743490
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39313313
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39295349
134Lysine degradation_Homo sapiens_hsa003100.35656663
135Alcoholism_Homo sapiens_hsa050340.35078449
136Arachidonic acid metabolism_Homo sapiens_hsa005900.34182043
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33571454
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33535556
139Graft-versus-host disease_Homo sapiens_hsa053320.33363657
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32883890

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