SIMC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.20061619
2DNA unwinding involved in DNA replication (GO:0006268)5.19530701
3nuclear pore complex assembly (GO:0051292)4.85507388
4nuclear pore organization (GO:0006999)4.80690471
5mitotic nuclear envelope disassembly (GO:0007077)4.08554409
6nucleobase biosynthetic process (GO:0046112)4.00365331
7purine nucleobase biosynthetic process (GO:0009113)3.99181808
8folic acid-containing compound biosynthetic process (GO:0009396)3.98893918
9resolution of meiotic recombination intermediates (GO:0000712)3.91551700
10nuclear envelope disassembly (GO:0051081)3.88036698
11membrane disassembly (GO:0030397)3.88036698
12mitotic chromosome condensation (GO:0007076)3.82805980
13protein localization to kinetochore (GO:0034501)3.77396857
14DNA replication initiation (GO:0006270)3.76663866
15head development (GO:0060322)3.75942446
16DNA replication-dependent nucleosome assembly (GO:0006335)3.71376962
17DNA replication-dependent nucleosome organization (GO:0034723)3.71376962
18protein K6-linked ubiquitination (GO:0085020)3.64120635
19protein polyglutamylation (GO:0018095)3.64104236
20regulation of RNA export from nucleus (GO:0046831)3.61072963
21pore complex assembly (GO:0046931)3.59460020
22replication fork processing (GO:0031297)3.53937576
23DNA duplex unwinding (GO:0032508)3.53712158
24DNA replication checkpoint (GO:0000076)3.51693281
25DNA geometric change (GO:0032392)3.49863978
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.48428647
27male meiosis I (GO:0007141)3.38516988
28histone H4-K5 acetylation (GO:0043981)3.35362282
29histone H4-K8 acetylation (GO:0043982)3.35362282
30translesion synthesis (GO:0019985)3.34942347
31regulation of nuclear cell cycle DNA replication (GO:0033262)3.32775865
32epithelial cilium movement (GO:0003351)3.31949843
33intra-S DNA damage checkpoint (GO:0031573)3.28849474
34histone H2A acetylation (GO:0043968)3.27830148
35protein localization to chromosome, centromeric region (GO:0071459)3.27047362
36regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.25591656
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.23529377
38behavioral response to nicotine (GO:0035095)3.23199144
39positive regulation of mitochondrial fission (GO:0090141)3.22753725
40mitotic metaphase plate congression (GO:0007080)3.19974201
41somatic hypermutation of immunoglobulin genes (GO:0016446)3.17702276
42somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17702276
43mismatch repair (GO:0006298)3.14460786
44nonmotile primary cilium assembly (GO:0035058)3.14224451
45regulation of DNA damage checkpoint (GO:2000001)3.12586929
46spermatid nucleus differentiation (GO:0007289)3.12562197
47regulation of chromatin binding (GO:0035561)3.12309632
48establishment of protein localization to Golgi (GO:0072600)3.10414293
49sister chromatid segregation (GO:0000819)3.09766066
50L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08238595
51recombinational repair (GO:0000725)3.07590759
52mitotic recombination (GO:0006312)3.06945687
53centriole replication (GO:0007099)3.05527229
54glucocorticoid receptor signaling pathway (GO:0042921)3.05255045
55double-strand break repair via homologous recombination (GO:0000724)3.04946034
56respiratory tube development (GO:0030323)3.04554852
57DNA double-strand break processing (GO:0000729)3.02554541
58DNA conformation change (GO:0071103)3.02315730
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.01153070
60snRNA metabolic process (GO:0016073)3.00998756
61positive regulation of gastrulation (GO:2000543)3.00697929
62IMP biosynthetic process (GO:0006188)3.00534518
63intraciliary transport (GO:0042073)3.00005797
64microtubule depolymerization (GO:0007019)2.98991159
65negative regulation of histone methylation (GO:0031061)2.98668726
66regulation of spindle organization (GO:0090224)2.98287952
67meiosis I (GO:0007127)2.96704999
68gene silencing by RNA (GO:0031047)2.96263960
69regulation of cilium movement (GO:0003352)2.96013709
70protein-DNA complex disassembly (GO:0032986)2.95779525
71nucleosome disassembly (GO:0006337)2.95779525
72nuclear envelope organization (GO:0006998)2.94934960
73meiotic chromosome segregation (GO:0045132)2.94102409
74negative regulation of mRNA metabolic process (GO:1903312)2.94079291
75histone H4-K12 acetylation (GO:0043983)2.93582682
76DNA integration (GO:0015074)2.93580464
77negative regulation of mitotic sister chromatid separation (GO:2000816)2.91777390
78negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91777390
79negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91777390
80negative regulation of sister chromatid segregation (GO:0033046)2.91777390
81DNA strand elongation involved in DNA replication (GO:0006271)2.91084134
82regulation of centriole replication (GO:0046599)2.90998576
83metaphase plate congression (GO:0051310)2.90398350
84cellular ketone body metabolic process (GO:0046950)2.90351484
85mitotic spindle assembly checkpoint (GO:0007094)2.89963115
86spindle assembly checkpoint (GO:0071173)2.89834126
87sperm motility (GO:0030317)2.89789862
88negative regulation of chromosome segregation (GO:0051985)2.89556551
89postreplication repair (GO:0006301)2.89250102
90mRNA transport (GO:0051028)2.89033887
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88080127
92synapsis (GO:0007129)2.87824836
93DNA packaging (GO:0006323)2.87491234
94regulation of centrosome cycle (GO:0046605)2.86839447
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85374094
96negative regulation of mRNA processing (GO:0050686)2.85008799
97DNA strand elongation (GO:0022616)2.83827401
98regulation of chromosome segregation (GO:0051983)2.83384034
99spermatid development (GO:0007286)2.81461771
100negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.81159168
101regulation of mitotic metaphase/anaphase transition (GO:0030071)2.80977608
102spindle checkpoint (GO:0031577)2.80604473
103chromosome condensation (GO:0030261)2.79269222
104acrosome reaction (GO:0007340)2.78697645
105sister chromatid cohesion (GO:0007062)2.77541670
106response to pheromone (GO:0019236)2.76669447
107regulation of histone H3-K9 methylation (GO:0051570)2.76653099
108cilium movement (GO:0003341)2.76241519
109dosage compensation (GO:0007549)2.76014248
110negative regulation of DNA recombination (GO:0045910)2.75583459
111reciprocal meiotic recombination (GO:0007131)2.75379263
112reciprocal DNA recombination (GO:0035825)2.75379263
113regulation of sister chromatid segregation (GO:0033045)2.74925621
114regulation of mitotic sister chromatid separation (GO:0010965)2.74925621
115regulation of mitotic sister chromatid segregation (GO:0033047)2.74925621
116peptidyl-lysine dimethylation (GO:0018027)2.74789875
117RNA export from nucleus (GO:0006405)2.74684086
118monoubiquitinated protein deubiquitination (GO:0035520)2.74262949
119snRNA processing (GO:0016180)2.74074054
120synaptonemal complex assembly (GO:0007130)2.73661087
121positive regulation of male gonad development (GO:2000020)2.73369563
122behavioral response to ethanol (GO:0048149)2.73305241
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.73018068
124histone H4-K16 acetylation (GO:0043984)2.72800410
125DNA topological change (GO:0006265)2.72665635
126protein localization to chromosome (GO:0034502)2.72616357
127pyrimidine nucleobase catabolic process (GO:0006208)2.71942692
128negative regulation of RNA splicing (GO:0033119)2.71827736
129protein targeting to Golgi (GO:0000042)2.71526942
130mitotic spindle checkpoint (GO:0071174)2.71488049
131mRNA export from nucleus (GO:0006406)2.70719914
132establishment of RNA localization (GO:0051236)2.70644684
133nucleic acid transport (GO:0050657)2.70644684
134microtubule polymerization or depolymerization (GO:0031109)2.70089455
135seminiferous tubule development (GO:0072520)2.66843195
136meiotic cell cycle process (GO:1903046)2.65377040
137ketone body metabolic process (GO:1902224)2.60739297
138cilium organization (GO:0044782)2.59861091
139cilium assembly (GO:0042384)2.59573258
140photoreceptor cell maintenance (GO:0045494)2.59350503
141amino acid salvage (GO:0043102)2.58871251
142L-methionine salvage (GO:0071267)2.58871251
143L-methionine biosynthetic process (GO:0071265)2.58871251
144neural tube formation (GO:0001841)2.57428267
145male meiosis (GO:0007140)2.53794858
146piRNA metabolic process (GO:0034587)2.52487586
147chromatin remodeling at centromere (GO:0031055)2.50418176
148cullin deneddylation (GO:0010388)2.50382458
149regulation of DNA endoreduplication (GO:0032875)2.50178390
150protein localization to Golgi apparatus (GO:0034067)2.49929353
151nucleotide-excision repair, DNA gap filling (GO:0006297)2.49818565
152microtubule anchoring (GO:0034453)2.47998985
153DNA methylation involved in gamete generation (GO:0043046)2.47169228
154respiratory chain complex IV assembly (GO:0008535)2.45466873
155retrograde transport, vesicle recycling within Golgi (GO:0000301)2.45414405
156chromosome organization involved in meiosis (GO:0070192)2.44055697
157histone H3-K9 methylation (GO:0051567)2.43101494
158cilium or flagellum-dependent cell motility (GO:0001539)2.43014674
159detection of light stimulus involved in sensory perception (GO:0050962)2.39554529
160detection of light stimulus involved in visual perception (GO:0050908)2.39554529
161methionine biosynthetic process (GO:0009086)2.39149546
162kynurenine metabolic process (GO:0070189)2.37661913
163negative regulation of telomere maintenance (GO:0032205)2.37261178
164negative regulation of transcription regulatory region DNA binding (GO:2000678)2.37097030
165meiotic nuclear division (GO:0007126)2.35114139
166transmission of nerve impulse (GO:0019226)2.33906916
167cilium morphogenesis (GO:0060271)2.33261884
168axoneme assembly (GO:0035082)2.33080919
169histone exchange (GO:0043486)2.32174620
170auditory receptor cell stereocilium organization (GO:0060088)2.31156878
171positive regulation of mRNA catabolic process (GO:0061014)2.28845575
172somite development (GO:0061053)2.28059445
173rRNA catabolic process (GO:0016075)2.27810850
174protein localization to cilium (GO:0061512)2.27358809
175double-strand break repair via nonhomologous end joining (GO:0006303)2.27324665
176non-recombinational repair (GO:0000726)2.27324665
177CENP-A containing nucleosome assembly (GO:0034080)2.26347937
178mitochondrial respiratory chain complex I assembly (GO:0032981)2.25249847
179NADH dehydrogenase complex assembly (GO:0010257)2.25249847
180mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.25249847
181determination of left/right symmetry (GO:0007368)2.24256666
182regulation of telomere maintenance (GO:0032204)2.23725181
183histone lysine methylation (GO:0034968)2.22977243
184regulation of helicase activity (GO:0051095)2.22757713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.64899788
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01083820
3EZH2_22144423_ChIP-Seq_EOC_Human4.00140366
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.73989282
5ZNF274_21170338_ChIP-Seq_K562_Hela3.55008670
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.47931947
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.45017415
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.35644326
9IGF1R_20145208_ChIP-Seq_DFB_Human3.23163276
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.01720056
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.95793977
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.87636277
13AR_21909140_ChIP-Seq_LNCAP_Human2.83330034
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74948413
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.72391200
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.51165895
17MYC_22102868_ChIP-Seq_BL_Human2.49464185
18GBX2_23144817_ChIP-Seq_PC3_Human2.47226690
19VDR_22108803_ChIP-Seq_LS180_Human2.35956226
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35545980
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27383396
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.24926017
23MYCN_18555785_ChIP-Seq_MESCs_Mouse2.18747448
24YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16867173
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12515441
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11453757
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09579988
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09226989
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09135677
30CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.04114326
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03869849
32E2F7_22180533_ChIP-Seq_HELA_Human11.1577448
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99319313
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98847141
35IRF1_19129219_ChIP-ChIP_H3396_Human1.97265866
36CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.96943528
37MYC_18940864_ChIP-ChIP_HL60_Human1.94995441
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89052965
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88767504
40CIITA_25753668_ChIP-Seq_RAJI_Human1.87221401
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.83698475
42TAF15_26573619_Chip-Seq_HEK293_Human1.82958336
43XRN2_22483619_ChIP-Seq_HELA_Human1.73701939
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73014585
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68911078
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68555827
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68401190
48CBP_20019798_ChIP-Seq_JUKART_Human1.68401190
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.65086269
50CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.63631537
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62974414
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61057955
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60215524
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60103093
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60013850
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59922129
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59819940
58ER_23166858_ChIP-Seq_MCF-7_Human1.57281056
59FOXP3_21729870_ChIP-Seq_TREG_Human1.55334309
60RNF2_27304074_Chip-Seq_NSC_Mouse1.54634818
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54473313
62P300_19829295_ChIP-Seq_ESCs_Human1.53622353
63TP53_22573176_ChIP-Seq_HFKS_Human1.50898397
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.50162587
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50050018
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49257732
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48754996
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.47534589
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47387062
70PKCTHETA_26484144_Chip-Seq_BREAST_Human1.46851035
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44980946
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43134570
73STAT3_23295773_ChIP-Seq_U87_Human1.42980295
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41960849
75KDM5A_27292631_Chip-Seq_BREAST_Human1.40971206
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40078732
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38679514
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38219026
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38193325
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38193325
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37920927
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37880291
83THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37544760
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36387573
85VDR_23849224_ChIP-Seq_CD4+_Human1.35394361
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34619574
87TTF2_22483619_ChIP-Seq_HELA_Human1.34164472
88ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34134975
89TCF4_23295773_ChIP-Seq_U87_Human1.34129987
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31523633
91TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30732890
92SMAD4_21799915_ChIP-Seq_A2780_Human1.30540779
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.27521034
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27063729
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25005919
96GABP_19822575_ChIP-Seq_HepG2_Human1.23121851
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22260743
98AR_25329375_ChIP-Seq_VCAP_Human1.22148719
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20903274
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20546335
101SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19400296
102MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16576772
103NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15032910
104REST_21632747_ChIP-Seq_MESCs_Mouse1.14932829
105ETS1_20019798_ChIP-Seq_JURKAT_Human1.14928669
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.13568135
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11723765
108REST_18959480_ChIP-ChIP_MESCs_Mouse1.11288385
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10749268
110TCF4_22108803_ChIP-Seq_LS180_Human1.09903109
111SMAD4_21741376_ChIP-Seq_EPCs_Human1.09629036
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09227561
113FLI1_27457419_Chip-Seq_LIVER_Mouse1.08803119
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08740611
115NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08428624
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07877869
117BCAT_22108803_ChIP-Seq_LS180_Human1.07223399
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06084966
119RUNX2_22187159_ChIP-Seq_PCA_Human1.05836543
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04817063
121FUS_26573619_Chip-Seq_HEK293_Human1.03309611
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03261161
123DCP1A_22483619_ChIP-Seq_HELA_Human1.02892134
124NCOR_22424771_ChIP-Seq_293T_Human1.02826148
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02325723
126E2F1_17053090_ChIP-ChIP_MCF-7_Human1.02163463
127JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01211639
128DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00078928
129PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98539631
130EZH2_27304074_Chip-Seq_ESCs_Mouse0.98428301
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97967441
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96993726
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96456728
134GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95268125
135PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94702909
136ERA_21632823_ChIP-Seq_H3396_Human0.94328275
137PIAS1_25552417_ChIP-Seq_VCAP_Human0.94094366
138NANOG_21062744_ChIP-ChIP_HESCs_Human0.93971865
139E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93686172
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92138408
141CHD1_26751641_Chip-Seq_LNCaP_Human0.91703005
142FLI1_21867929_ChIP-Seq_TH2_Mouse0.91621865
143HOXB7_26014856_ChIP-Seq_BT474_Human0.91447858
144KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90243430
145NANOG_19829295_ChIP-Seq_ESCs_Human0.88757635
146SOX2_19829295_ChIP-Seq_ESCs_Human0.88757635
147ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88533430
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87725055
149KLF4_18555785_ChIP-Seq_MESCs_Mouse0.86363294
150POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86241987
151CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.84477999
152CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83639900
153CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.82982908
154AR_20517297_ChIP-Seq_VCAP_Human0.82654458
155CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81736159
156TCF7_22412390_ChIP-Seq_EML_Mouse0.81409604
157TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80777750
158TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.77914289
159SOX2_16153702_ChIP-ChIP_HESCs_Human0.76885689
160ELK1_19687146_ChIP-ChIP_HELA_Human0.75003083
161HOXB4_20404135_ChIP-ChIP_EML_Mouse0.74832393
162NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.73757788
163TBX3_20139965_ChIP-Seq_ESCs_Mouse0.72627837
164ZFP281_27345836_Chip-Seq_ESCs_Mouse0.72365390
165POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.71928577
166EWS_26573619_Chip-Seq_HEK293_Human0.71564978
167NANOG_16153702_ChIP-ChIP_HESCs_Human0.71497076
168FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.71408383
169TBX3_20139965_ChIP-Seq_MESCs_Mouse0.70751063

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.76690116
2MP0008877_abnormal_DNA_methylation3.68642774
3MP0008057_abnormal_DNA_replication3.37558928
4MP0003693_abnormal_embryo_hatching3.29041374
5MP0003111_abnormal_nucleus_morphology3.03915557
6MP0003123_paternal_imprinting2.86249124
7MP0008007_abnormal_cellular_replicative2.77668804
8MP0003077_abnormal_cell_cycle2.67739962
9MP0009053_abnormal_anal_canal2.67165850
10MP0004957_abnormal_blastocyst_morpholog2.66945425
11MP0003890_abnormal_embryonic-extraembry2.57198313
12MP0003121_genomic_imprinting2.51182484
13MP0000566_synostosis2.49774583
14MP0002102_abnormal_ear_morphology2.40303322
15MP0008058_abnormal_DNA_repair2.32746962
16MP0005645_abnormal_hypothalamus_physiol2.23712789
17MP0003646_muscle_fatigue2.23334129
18MP0000569_abnormal_digit_pigmentation2.23274003
19MP0005076_abnormal_cell_differentiation2.15539643
20MP0003119_abnormal_digestive_system2.15448073
21MP0008995_early_reproductive_senescence2.09181138
22MP0003787_abnormal_imprinting2.09017163
23MP0003283_abnormal_digestive_organ2.08353358
24MP0002822_catalepsy2.08318938
25MP0003115_abnormal_respiratory_system2.07699125
26MP0001529_abnormal_vocalization1.94280014
27MP0000537_abnormal_urethra_morphology1.89560179
28MP0010307_abnormal_tumor_latency1.87086957
29MP0006276_abnormal_autonomic_nervous1.85410931
30MP0000372_irregular_coat_pigmentation1.84759967
31MP0010030_abnormal_orbit_morphology1.82789455
32MP0002396_abnormal_hematopoietic_system1.82036967
33MP0005499_abnormal_olfactory_system1.80357050
34MP0005394_taste/olfaction_phenotype1.80357050
35MP0001730_embryonic_growth_arrest1.77564724
36MP0004133_heterotaxia1.76789394
37MP0000350_abnormal_cell_proliferation1.76145390
38MP0004197_abnormal_fetal_growth/weight/1.74878832
39MP0008789_abnormal_olfactory_epithelium1.67821501
40MP0002210_abnormal_sex_determination1.66375891
41MP0009046_muscle_twitch1.64087592
42MP0010352_gastrointestinal_tract_polyps1.63794160
43MP0002084_abnormal_developmental_patter1.63230141
44MP0003122_maternal_imprinting1.60734398
45MP0003943_abnormal_hepatobiliary_system1.60082645
46MP0009672_abnormal_birth_weight1.58539236
47MP0005380_embryogenesis_phenotype1.57260573
48MP0001672_abnormal_embryogenesis/_devel1.57260573
49MP0003786_premature_aging1.56815355
50MP0001929_abnormal_gametogenesis1.56039387
51MP0002085_abnormal_embryonic_tissue1.53600448
52MP0003942_abnormal_urinary_system1.52911273
53MP0004808_abnormal_hematopoietic_stem1.52451326
54MP0001697_abnormal_embryo_size1.48218646
55MP0003984_embryonic_growth_retardation1.47287328
56MP0003718_maternal_effect1.46851451
57MP0002088_abnormal_embryonic_growth/wei1.46623619
58MP0009697_abnormal_copulation1.43436621
59MP0005646_abnormal_pituitary_gland1.42518152
60MP0005551_abnormal_eye_electrophysiolog1.39954269
61MP0004142_abnormal_muscle_tone1.37923631
62MP0004043_abnormal_pH_regulation1.36124856
63MP0003880_abnormal_central_pattern1.35687423
64MP0001145_abnormal_male_reproductive1.34820869
65MP0001984_abnormal_olfaction1.33781104
66MP0008932_abnormal_embryonic_tissue1.32884425
67MP0001293_anophthalmia1.32487938
68MP0002233_abnormal_nose_morphology1.31456266
69MP0001968_abnormal_touch/_nociception1.30689557
70MP0000534_abnormal_ureter_morphology1.30271615
71MP0001485_abnormal_pinna_reflex1.29484165
72MP0000428_abnormal_craniofacial_morphol1.29449315
73MP0009745_abnormal_behavioral_response1.29441648
74MP0000653_abnormal_sex_gland1.25716901
75MP0003698_abnormal_male_reproductive1.25092830
76MP0002249_abnormal_larynx_morphology1.24406672
77MP0002080_prenatal_lethality1.23979492
78MP0002653_abnormal_ependyma_morphology1.23865376
79MP0002938_white_spotting1.21668900
80MP0005253_abnormal_eye_physiology1.19070835
81MP0003937_abnormal_limbs/digits/tail_de1.17349240
82MP0002557_abnormal_social/conspecific_i1.16562621
83MP0001764_abnormal_homeostasis1.15532907
84MP0002736_abnormal_nociception_after1.15068016
85MP0003195_calcinosis1.14565942
86MP0000778_abnormal_nervous_system1.14106869
87MP0000049_abnormal_middle_ear1.13401178
88MP0003755_abnormal_palate_morphology1.13355838
89MP0003935_abnormal_craniofacial_develop1.13207338
90MP0004145_abnormal_muscle_electrophysio1.11081834
91MP0004134_abnormal_chest_morphology1.11033162
92MP0006292_abnormal_olfactory_placode1.10901589
93MP0000631_abnormal_neuroendocrine_gland1.09620601
94MP0002086_abnormal_extraembryonic_tissu1.08787938
95MP0003385_abnormal_body_wall1.08071364
96MP0002928_abnormal_bile_duct1.06814719
97MP0003861_abnormal_nervous_system1.06294439
98MP0002837_dystrophic_cardiac_calcinosis1.05926427
99MP0009703_decreased_birth_body1.04943094
100MP0002735_abnormal_chemical_nociception1.03334670
101MP0005410_abnormal_fertilization1.00665639
102MP0002234_abnormal_pharynx_morphology1.00096381
103MP0002272_abnormal_nervous_system0.99173957
104MP0005248_abnormal_Harderian_gland0.96805682
105MP0002114_abnormal_axial_skeleton0.95954169
106MP0002116_abnormal_craniofacial_bone0.95607026
107MP0002160_abnormal_reproductive_system0.95162636
108MP0001119_abnormal_female_reproductive0.94865811
109MP0001286_abnormal_eye_development0.94395307
110MP0006072_abnormal_retinal_apoptosis0.94178733
111MP0002092_abnormal_eye_morphology0.93605545
112MP0000678_abnormal_parathyroid_gland0.93072664
113MP0002161_abnormal_fertility/fecundity0.92956948
114MP0002111_abnormal_tail_morphology0.92843878
115MP0008961_abnormal_basal_metabolism0.92523143
116MP0000432_abnormal_head_morphology0.92005737
117MP0002751_abnormal_autonomic_nervous0.91755247
118MP0001919_abnormal_reproductive_system0.90544908
119MP0005409_darkened_coat_color0.90395694
120MP0001849_ear_inflammation0.90120714
121MP0006035_abnormal_mitochondrial_morpho0.90112455
122MP0003567_abnormal_fetal_cardiomyocyte0.89842959
123MP0002572_abnormal_emotion/affect_behav0.89541511
124MP0000313_abnormal_cell_death0.89439163
125MP0009780_abnormal_chondrocyte_physiolo0.89378890
126MP0001944_abnormal_pancreas_morphology0.88929834
127MP0005379_endocrine/exocrine_gland_phen0.88694384
128MP0002163_abnormal_gland_morphology0.87986265
129MP0002184_abnormal_innervation0.87590456
130MP0005187_abnormal_penis_morphology0.87037706
131MP0000639_abnormal_adrenal_gland0.86676902
132MP0008872_abnormal_physiological_respon0.86114115
133MP0003938_abnormal_ear_development0.85574742
134MP0005386_behavior/neurological_phenoty0.85357561
135MP0004924_abnormal_behavior0.85357561
136MP0002932_abnormal_joint_morphology0.85136017
137MP0002064_seizures0.84232763
138MP0004742_abnormal_vestibular_system0.83212375
139MP0001501_abnormal_sleep_pattern0.83198345
140MP0005389_reproductive_system_phenotype0.82548517
141MP0001270_distended_abdomen0.82418941
142MP0005220_abnormal_exocrine_pancreas0.82415692
143MP0002752_abnormal_somatic_nervous0.82018090
144MP0005670_abnormal_white_adipose0.81262087
145MP0002081_perinatal_lethality0.80148408
146MP0000427_abnormal_hair_cycle0.79895265
147MP0002067_abnormal_sensory_capabilities0.79888754
148MP0000703_abnormal_thymus_morphology0.79655015
149MP0002109_abnormal_limb_morphology0.79427033
150MP0003806_abnormal_nucleotide_metabolis0.78412853
151MP0005075_abnormal_melanosome_morpholog0.78291379
152MP0000026_abnormal_inner_ear0.77178326
153MP0001486_abnormal_startle_reflex0.76807587
154MP0005384_cellular_phenotype0.76473010
155MP0001324_abnormal_eye_pigmentation0.75744673
156MP0005367_renal/urinary_system_phenotyp0.74846110
157MP0000516_abnormal_urinary_system0.74846110
158MP0002177_abnormal_outer_ear0.74460249
159MP0003763_abnormal_thymus_physiology0.73129145
160MP0009250_abnormal_appendicular_skeleto0.72378948
161MP0003699_abnormal_female_reproductive0.71693139
162MP0001299_abnormal_eye_distance/0.71490440
163MP0002019_abnormal_tumor_incidence0.71489065

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.98288398
2Ependymoma (HP:0002888)3.92575414
3Hyperventilation (HP:0002883)3.74855343
4Birth length less than 3rd percentile (HP:0003561)3.67107482
5Abnormality of the astrocytes (HP:0100707)3.45266728
6Astrocytoma (HP:0009592)3.45266728
7Colon cancer (HP:0003003)3.43956533
8Abnormality of midbrain morphology (HP:0002418)3.07395347
9Molar tooth sign on MRI (HP:0002419)3.07395347
10Degeneration of anterior horn cells (HP:0002398)3.00150986
11Abnormality of the anterior horn cell (HP:0006802)3.00150986
12Glioma (HP:0009733)2.98392935
13Ectopic kidney (HP:0000086)2.95393646
14Aplasia/Hypoplasia of the sternum (HP:0006714)2.94554421
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.94145319
16Nephronophthisis (HP:0000090)2.93415470
17Medial flaring of the eyebrow (HP:0010747)2.93232396
18Gait imbalance (HP:0002141)2.93092292
19Congenital primary aphakia (HP:0007707)2.91262121
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.88554953
21Short 4th metacarpal (HP:0010044)2.88554953
22Papillary thyroid carcinoma (HP:0002895)2.85738909
23Chromsome breakage (HP:0040012)2.82216936
24Abnormality of the fingertips (HP:0001211)2.75850087
25Nephrogenic diabetes insipidus (HP:0009806)2.75158447
26Chronic hepatic failure (HP:0100626)2.69282041
27Volvulus (HP:0002580)2.67635437
28Abnormality of the renal cortex (HP:0011035)2.65351412
29Poor coordination (HP:0002370)2.58668953
30Abnormality of the labia minora (HP:0012880)2.58182376
31Medulloblastoma (HP:0002885)2.54356387
32Genetic anticipation (HP:0003743)2.52683752
33Abnormality of the renal medulla (HP:0100957)2.52324011
34Patellar aplasia (HP:0006443)2.51260070
35Oligodactyly (hands) (HP:0001180)2.48798544
36Abnormal pancreas size (HP:0012094)2.45232932
37Cystic liver disease (HP:0006706)2.42864488
38Attenuation of retinal blood vessels (HP:0007843)2.37896156
39Long eyelashes (HP:0000527)2.37502625
40Abnormality of chromosome stability (HP:0003220)2.35570751
41Vaginal atresia (HP:0000148)2.34964880
42Abnormality of the intervertebral disk (HP:0005108)2.34797361
43Genital tract atresia (HP:0001827)2.33899168
44Deviation of the thumb (HP:0009603)2.31984818
45Selective tooth agenesis (HP:0001592)2.31100191
46Sclerocornea (HP:0000647)2.29498990
47Proximal placement of thumb (HP:0009623)2.29277790
4811 pairs of ribs (HP:0000878)2.27831680
49Atrophy/Degeneration involving motor neurons (HP:0007373)2.27347431
50Gastrointestinal carcinoma (HP:0002672)2.22984932
51Malignant gastrointestinal tract tumors (HP:0006749)2.22984932
52Postaxial foot polydactyly (HP:0001830)2.22275815
53Aplasia/Hypoplasia of the patella (HP:0006498)2.21420979
54Nephroblastoma (Wilms tumor) (HP:0002667)2.20494075
55Abnormality of the parathyroid morphology (HP:0011766)2.18171778
56Preaxial hand polydactyly (HP:0001177)2.17981389
57Abnormality of the lower motor neuron (HP:0002366)2.16324864
58Intestinal atresia (HP:0011100)2.15306188
59Leiomyosarcoma (HP:0100243)2.15221589
60Uterine leiomyosarcoma (HP:0002891)2.15221589
61Hypoplastic iliac wings (HP:0002866)2.12195425
62Abnormal lung lobation (HP:0002101)2.09763112
63Congenital stationary night blindness (HP:0007642)2.07956922
64Abnormality of the aortic arch (HP:0012303)2.07012961
65Meckel diverticulum (HP:0002245)2.06841651
66Male pseudohermaphroditism (HP:0000037)2.06517587
67Bony spicule pigmentary retinopathy (HP:0007737)2.06214932
68Methylmalonic aciduria (HP:0012120)2.05723965
69Prominent nose (HP:0000448)2.04297214
70Transitional cell carcinoma of the bladder (HP:0006740)2.03153504
71Renal cortical cysts (HP:0000803)2.00175719
72Supernumerary spleens (HP:0009799)1.99482816
73Aplasia/Hypoplasia of the uvula (HP:0010293)1.98837923
74Impulsivity (HP:0100710)1.98641196
75Embryonal renal neoplasm (HP:0011794)1.98125170
76Anencephaly (HP:0002323)1.97621284
77Shawl scrotum (HP:0000049)1.97245568
78Neoplasm of the pancreas (HP:0002894)1.97016383
79Facial hemangioma (HP:0000329)1.96830641
80Optic nerve coloboma (HP:0000588)1.96416192
81Pendular nystagmus (HP:0012043)1.96280184
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.96135708
83Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.95182765
84Amyotrophic lateral sclerosis (HP:0007354)1.94981662
85Hepatoblastoma (HP:0002884)1.94880289
86Sloping forehead (HP:0000340)1.94763294
87Astigmatism (HP:0000483)1.94382216
88Postaxial hand polydactyly (HP:0001162)1.94278396
89Broad thumb (HP:0011304)1.94201499
90Short 5th finger (HP:0009237)1.93931026
91Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.93420403
92Abnormality of the ileum (HP:0001549)1.93418010
93Broad palm (HP:0001169)1.92961023
94Truncal obesity (HP:0001956)1.92092135
95Aplasia/Hypoplasia of the tongue (HP:0010295)1.91762952
96Abnormality of the 4th metacarpal (HP:0010012)1.91536489
97Retinal dysplasia (HP:0007973)1.90075152
98Congenital hepatic fibrosis (HP:0002612)1.89510609
99Abdominal situs inversus (HP:0003363)1.89372533
100Abnormality of abdominal situs (HP:0011620)1.89372533
101Abnormality of the metopic suture (HP:0005556)1.89223000
102Duodenal stenosis (HP:0100867)1.87842499
103Small intestinal stenosis (HP:0012848)1.87842499
104Breast hypoplasia (HP:0003187)1.87639035
105Biliary tract neoplasm (HP:0100574)1.87552511
106Gaze-evoked nystagmus (HP:0000640)1.87142334
107Febrile seizures (HP:0002373)1.87039846
108Progressive cerebellar ataxia (HP:0002073)1.86936648
109Shoulder girdle muscle weakness (HP:0003547)1.85424610
110Long palpebral fissure (HP:0000637)1.84956223
111Abnormal biliary tract morphology (HP:0012440)1.84555300
112Renovascular hypertension (HP:0100817)1.84336148
113Breast aplasia (HP:0100783)1.84089686
114True hermaphroditism (HP:0010459)1.83022119
115Abnormality of the renal collecting system (HP:0004742)1.82407107
116Duplicated collecting system (HP:0000081)1.81389866
117Oligodactyly (HP:0012165)1.80550413
118Microglossia (HP:0000171)1.80353519
119Increased nuchal translucency (HP:0010880)1.80216979
120Neoplasm of the oral cavity (HP:0100649)1.79218398
121Cafe-au-lait spot (HP:0000957)1.78715740
122Polydipsia (HP:0001959)1.78504417
123Abnormal drinking behavior (HP:0030082)1.78504417
124Congenital malformation of the right heart (HP:0011723)1.78311220
125Double outlet right ventricle (HP:0001719)1.78311220
126Broad phalanges of the hand (HP:0009768)1.77249404
127Aqueductal stenosis (HP:0002410)1.77231906
128High anterior hairline (HP:0009890)1.77067173
129Abnormality of the duodenum (HP:0002246)1.77052223
130Aganglionic megacolon (HP:0002251)1.76231974
131Trigonocephaly (HP:0000243)1.76105882
132Dandy-Walker malformation (HP:0001305)1.75869774
133Prominent metopic ridge (HP:0005487)1.74973273
134Occipital encephalocele (HP:0002085)1.74907576
135Bile duct proliferation (HP:0001408)1.74831297
136Abnormal biliary tract physiology (HP:0012439)1.74831297
137Bladder neoplasm (HP:0009725)1.74787717
138Bladder carcinoma (HP:0002862)1.74787717
139Clubbing of toes (HP:0100760)1.74770947
140Dislocated radial head (HP:0003083)1.74375736
141Abnormality of DNA repair (HP:0003254)1.73944185
142Multicystic kidney dysplasia (HP:0000003)1.73759750
143Urethral obstruction (HP:0000796)1.73526574
144Abnormality of the calcaneus (HP:0008364)1.73264475
145Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.72913993
146Lissencephaly (HP:0001339)1.72304239
147Uterine neoplasm (HP:0010784)1.72040898
148Anal stenosis (HP:0002025)1.71594042
149Limb hypertonia (HP:0002509)1.71556390
150Small epiphyses (HP:0010585)1.70945863
151Abnormal number of incisors (HP:0011064)1.70749242
152Short ribs (HP:0000773)1.69999900
153Abnormality of the carotid arteries (HP:0005344)1.69254992
154Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68712581
155Abnormality of alanine metabolism (HP:0010916)1.68712581
156Hyperalaninemia (HP:0003348)1.68712581
157Absent forearm bone (HP:0003953)1.67993710
158Aplasia involving forearm bones (HP:0009822)1.67993710
159Abnormality of the radial head (HP:0003995)1.67948851
160Highly arched eyebrow (HP:0002553)1.67403444
161Absent radius (HP:0003974)1.67123331
162Abnormal rod and cone electroretinograms (HP:0008323)1.67078430
163Posterior subcapsular cataract (HP:0007787)1.66962852
164Tubular atrophy (HP:0000092)1.66942219
165Atresia of the external auditory canal (HP:0000413)1.66827008
166Deep philtrum (HP:0002002)1.65112597
167Pancreatic fibrosis (HP:0100732)1.64950680
168Atonic seizures (HP:0010819)1.64775256
169Triphalangeal thumb (HP:0001199)1.64664170
170Overlapping toe (HP:0001845)1.64515852
171Limited elbow extension (HP:0001377)1.64476344
172Spinal muscular atrophy (HP:0007269)1.64272058
173Progressive sensorineural hearing impairment (HP:0000408)1.63961463
174Bicornuate uterus (HP:0000813)1.63886829
175Congenital sensorineural hearing impairment (HP:0008527)1.63334174
176Absent speech (HP:0001344)1.62593398
177Broad foot (HP:0001769)1.61745631
178Bifid tongue (HP:0010297)1.61587652
179Mesangial abnormality (HP:0001966)1.60732295
180Obsessive-compulsive behavior (HP:0000722)1.60212403
181Abnormality of the preputium (HP:0100587)1.60167106
182Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60138019
183Neoplasm of striated muscle (HP:0009728)1.59714383
184Rhabdomyosarcoma (HP:0002859)1.58713284
185Slender long bone (HP:0003100)1.58625083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.05480587
2FRK4.27454095
3CDK124.14449021
4MAP4K23.47533177
5WEE13.38797375
6INSRR2.86499622
7PASK2.81821264
8BRD42.78539643
9BMPR1B2.62414015
10PINK12.53104300
11TRIM282.50559346
12NUAK12.49582009
13TSSK62.36241779
14NEK22.11077533
15BCKDK2.07354597
16BRSK22.05388331
17PLK32.05244741
18WNK41.99826173
19EIF2AK11.97551892
20ZAK1.91009742
21MAPK131.81128619
22ACVR1B1.80984978
23CSNK1A1L1.79160417
24BCR1.78929242
25ATR1.78672525
26MKNK11.75590713
27ERBB31.73125994
28CSNK1G31.73050992
29CASK1.70002890
30SRPK11.68372411
31TTK1.63459475
32STK391.61148051
33CSNK1G11.60587003
34NEK11.59345058
35CCNB11.56551318
36BUB11.54695520
37CHEK11.53522479
38VRK11.51662440
39CDK71.51124647
40STK38L1.47101022
41CAMK1G1.43902927
42EEF2K1.43590952
43EIF2AK31.43448293
44CSNK1G21.40452969
45KSR11.40327909
46MAP2K71.37947420
47MKNK21.35066260
48BRSK11.34124700
49STK161.33207040
50CDK191.31272932
51CHEK21.26761188
52PLK11.25682460
53CAMK41.25246475
54ADRBK21.20025878
55MARK11.18920899
56VRK21.13360601
57MTOR1.13230426
58RPS6KA41.12938768
59ATM1.12130826
60CDK21.11378748
61MAP3K101.09872436
62FGFR11.07118101
63MAP3K81.03865221
64PLK41.01834006
65CAMK1D1.01434710
66CDK81.01158403
67MELK0.99705004
68AURKB0.99392523
69CDK10.98034278
70MAPKAPK50.95154426
71TGFBR10.94900819
72DYRK1A0.93341805
73CDK40.93012000
74PNCK0.92331935
75LATS20.92044898
76YES10.91012315
77NTRK30.87877283
78BRAF0.87011970
79GRK10.85717561
80PAK60.85324727
81TLK10.81294936
82DYRK30.79422389
83MAPK100.78529935
84LATS10.78273873
85RPS6KB10.78224560
86MAPK90.75686875
87AKT30.74134118
88STK30.73769634
89PDK30.72883756
90PDK40.72883756
91TNIK0.71964585
92MAP3K40.71286162
93PRKCG0.69313810
94PLK20.68370980
95MAP3K90.67101098
96CAMK10.66681345
97EIF2AK20.66395266
98DYRK20.65709865
99SIK20.65197626
100RAF10.63653327
101OXSR10.63369511
102PRKDC0.63298613
103PDGFRA0.62176326
104CAMKK20.61957857
105RPS6KA50.61047415
106PAK20.60542827
107DYRK1B0.59298224
108MAP2K40.59215554
109SGK30.58815538
110STK100.58689423
111WNK30.57590126
112MAP3K50.57072260
113DAPK20.56845930
114STK240.56689851
115MAPK140.55189892
116TAOK10.54437672
117PRKD30.54424846
118MAPK80.53460207
119GSK3B0.53389090
120ALK0.52600749
121PAK30.51984623
122EPHA40.51474947
123SCYL20.48742666
124FLT30.48150621
125NTRK20.47838162
126PRKCE0.47648979
127MAP3K60.47624003
128CSNK1A10.46821176
129RPS6KA20.46752107
130TAF10.46384428
131CHUK0.43056263
132CDK60.42213428
133HIPK20.41959639
134MAPK10.41018759
135MINK10.40674002
136PRKCZ0.40582569
137AKT10.39557609
138CSNK1E0.37879465
139MARK30.37347806
140PRKAA10.36643490
141CDK180.36507962
142ADRBK10.36170423
143NME10.35485893
144AURKA0.35254935
145DAPK10.35181253
146SGK20.34860987
147RPS6KA60.34675256
148CSNK1D0.33924821
149CAMK2A0.32869267
150FGFR20.31658995

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.59093643
2Cell cycle_Homo sapiens_hsa041103.21085139
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.18203174
4Mismatch repair_Homo sapiens_hsa034303.10101268
5RNA transport_Homo sapiens_hsa030132.96510661
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93096201
7Spliceosome_Homo sapiens_hsa030402.74382793
8One carbon pool by folate_Homo sapiens_hsa006702.66338513
9Homologous recombination_Homo sapiens_hsa034402.51542742
10Butanoate metabolism_Homo sapiens_hsa006502.48345452
11Base excision repair_Homo sapiens_hsa034102.39583788
12Fanconi anemia pathway_Homo sapiens_hsa034602.36381454
13mRNA surveillance pathway_Homo sapiens_hsa030152.29405759
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26934827
15Propanoate metabolism_Homo sapiens_hsa006402.18593170
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11894946
17RNA polymerase_Homo sapiens_hsa030201.97906440
18Selenocompound metabolism_Homo sapiens_hsa004501.88795937
19Non-homologous end-joining_Homo sapiens_hsa034501.83872791
20Phototransduction_Homo sapiens_hsa047441.82725001
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77406479
22Nucleotide excision repair_Homo sapiens_hsa034201.76505127
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73980000
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65723866
25Pyrimidine metabolism_Homo sapiens_hsa002401.64682242
26Basal transcription factors_Homo sapiens_hsa030221.64347140
27RNA degradation_Homo sapiens_hsa030181.62194780
28Oocyte meiosis_Homo sapiens_hsa041141.58654499
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.56050812
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.54064332
31Steroid biosynthesis_Homo sapiens_hsa001001.52400578
32Thyroid cancer_Homo sapiens_hsa052161.40710058
33p53 signaling pathway_Homo sapiens_hsa041151.40479510
34Viral carcinogenesis_Homo sapiens_hsa052031.39329843
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.30612377
36Lysine degradation_Homo sapiens_hsa003101.28086745
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27581579
38Regulation of autophagy_Homo sapiens_hsa041401.24233749
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22337450
40Colorectal cancer_Homo sapiens_hsa052101.21895049
41Taste transduction_Homo sapiens_hsa047421.21693707
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.21390630
43MicroRNAs in cancer_Homo sapiens_hsa052061.20190669
44HTLV-I infection_Homo sapiens_hsa051661.19479384
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18678575
46Peroxisome_Homo sapiens_hsa041461.18491137
47Olfactory transduction_Homo sapiens_hsa047401.16991068
48Huntingtons disease_Homo sapiens_hsa050161.16487411
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.16348104
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15499368
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13012544
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10526202
53Insulin secretion_Homo sapiens_hsa049111.09036218
54Endometrial cancer_Homo sapiens_hsa052131.06594555
55Epstein-Barr virus infection_Homo sapiens_hsa051691.05778322
56Purine metabolism_Homo sapiens_hsa002301.04992960
57Oxidative phosphorylation_Homo sapiens_hsa001901.04537941
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04468041
59Parkinsons disease_Homo sapiens_hsa050121.03616433
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02789167
61Proteasome_Homo sapiens_hsa030501.00869885
62Fatty acid metabolism_Homo sapiens_hsa012120.98657325
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97555550
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.95149377
65Systemic lupus erythematosus_Homo sapiens_hsa053220.94848722
66Fatty acid elongation_Homo sapiens_hsa000620.93503308
67Prostate cancer_Homo sapiens_hsa052150.92372735
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92314852
69Vitamin B6 metabolism_Homo sapiens_hsa007500.92192013
70mTOR signaling pathway_Homo sapiens_hsa041500.91697815
71ABC transporters_Homo sapiens_hsa020100.89163726
72Estrogen signaling pathway_Homo sapiens_hsa049150.88481363
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88216143
74Alcoholism_Homo sapiens_hsa050340.87836071
75Dorso-ventral axis formation_Homo sapiens_hsa043200.87107666
76Linoleic acid metabolism_Homo sapiens_hsa005910.87076057
77Type II diabetes mellitus_Homo sapiens_hsa049300.86480624
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86405082
79Sulfur relay system_Homo sapiens_hsa041220.84668579
80Herpes simplex infection_Homo sapiens_hsa051680.83793683
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83278723
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.83115067
83Chronic myeloid leukemia_Homo sapiens_hsa052200.83013252
84Non-small cell lung cancer_Homo sapiens_hsa052230.82896149
85GABAergic synapse_Homo sapiens_hsa047270.82105539
86Morphine addiction_Homo sapiens_hsa050320.80211012
87Tryptophan metabolism_Homo sapiens_hsa003800.79333565
88Cocaine addiction_Homo sapiens_hsa050300.78251529
89Basal cell carcinoma_Homo sapiens_hsa052170.77991981
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.77404033
91Folate biosynthesis_Homo sapiens_hsa007900.76860169
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76002821
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.75063380
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69718938
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69538647
96Metabolic pathways_Homo sapiens_hsa011000.69508595
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68492419
98Small cell lung cancer_Homo sapiens_hsa052220.67862151
99N-Glycan biosynthesis_Homo sapiens_hsa005100.67507216
100Circadian entrainment_Homo sapiens_hsa047130.67275004
101TGF-beta signaling pathway_Homo sapiens_hsa043500.67012596
102Nicotine addiction_Homo sapiens_hsa050330.65815090
103Hippo signaling pathway_Homo sapiens_hsa043900.65393523
104Pancreatic cancer_Homo sapiens_hsa052120.62472389
105Ovarian steroidogenesis_Homo sapiens_hsa049130.61499749
106Chemical carcinogenesis_Homo sapiens_hsa052040.61246649
107Amphetamine addiction_Homo sapiens_hsa050310.61217904
108Fat digestion and absorption_Homo sapiens_hsa049750.60516689
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58727208
110Acute myeloid leukemia_Homo sapiens_hsa052210.57630393
111Wnt signaling pathway_Homo sapiens_hsa043100.56196215
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56183094
113Bladder cancer_Homo sapiens_hsa052190.56128294
114Hepatitis B_Homo sapiens_hsa051610.54537256
115Glioma_Homo sapiens_hsa052140.53784625
116Notch signaling pathway_Homo sapiens_hsa043300.53708387
117Prolactin signaling pathway_Homo sapiens_hsa049170.52599538
118T cell receptor signaling pathway_Homo sapiens_hsa046600.52138988
119Glucagon signaling pathway_Homo sapiens_hsa049220.51747765
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51514637
121Antigen processing and presentation_Homo sapiens_hsa046120.50789068
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50677720
123Arginine biosynthesis_Homo sapiens_hsa002200.50622776
124Ether lipid metabolism_Homo sapiens_hsa005650.50424733
125Glutamatergic synapse_Homo sapiens_hsa047240.50003614
126FoxO signaling pathway_Homo sapiens_hsa040680.49549430
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48653964
128Alzheimers disease_Homo sapiens_hsa050100.48179617
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48126466
130Long-term potentiation_Homo sapiens_hsa047200.46779443
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.45539654
132Fatty acid degradation_Homo sapiens_hsa000710.44949570
133Biosynthesis of amino acids_Homo sapiens_hsa012300.44577454
134Retinol metabolism_Homo sapiens_hsa008300.44426646
135Arginine and proline metabolism_Homo sapiens_hsa003300.44294092
136Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43940366
137Vitamin digestion and absorption_Homo sapiens_hsa049770.43698881
138ErbB signaling pathway_Homo sapiens_hsa040120.43360187
139Circadian rhythm_Homo sapiens_hsa047100.42789785
140Calcium signaling pathway_Homo sapiens_hsa040200.42776595
141Hedgehog signaling pathway_Homo sapiens_hsa043400.41840644
142Protein export_Homo sapiens_hsa030600.41207006
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40858992
144Type I diabetes mellitus_Homo sapiens_hsa049400.39657781
145Long-term depression_Homo sapiens_hsa047300.39481695
146Serotonergic synapse_Homo sapiens_hsa047260.38447186
147Nitrogen metabolism_Homo sapiens_hsa009100.38386012
148beta-Alanine metabolism_Homo sapiens_hsa004100.38210510
149Pathways in cancer_Homo sapiens_hsa052000.36595971
150Thyroid hormone synthesis_Homo sapiens_hsa049180.35104567
151Gap junction_Homo sapiens_hsa045400.35034385
152Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33946086
153Pentose phosphate pathway_Homo sapiens_hsa000300.33379367
154cAMP signaling pathway_Homo sapiens_hsa040240.32981649
155Dopaminergic synapse_Homo sapiens_hsa047280.31325823
156Renal cell carcinoma_Homo sapiens_hsa052110.30756672
157B cell receptor signaling pathway_Homo sapiens_hsa046620.30413005
158Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30012746
159AMPK signaling pathway_Homo sapiens_hsa041520.29788570
160Proteoglycans in cancer_Homo sapiens_hsa052050.27489610

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