

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore complex assembly (GO:0051292) | 5.78437481 |
| 2 | nuclear pore organization (GO:0006999) | 5.68973113 |
| 3 | regulation of DNA methylation (GO:0044030) | 5.08033467 |
| 4 | positive regulation of histone H3-K4 methylation (GO:0051571) | 4.78831909 |
| 5 | mitotic chromosome condensation (GO:0007076) | 4.77750938 |
| 6 | mitotic sister chromatid cohesion (GO:0007064) | 4.69785738 |
| 7 | protein localization to kinetochore (GO:0034501) | 4.57262045 |
| 8 | mitotic nuclear envelope disassembly (GO:0007077) | 4.44695597 |
| 9 | pre-miRNA processing (GO:0031054) | 4.30661319 |
| 10 | regulation of histone H3-K4 methylation (GO:0051569) | 4.28206227 |
| 11 | histone H3-K36 demethylation (GO:0070544) | 4.27792337 |
| 12 | pore complex assembly (GO:0046931) | 4.27767447 |
| 13 | regulation of acrosome reaction (GO:0060046) | 4.27325927 |
| 14 | DNA unwinding involved in DNA replication (GO:0006268) | 4.16582763 |
| 15 | membrane disassembly (GO:0030397) | 4.16080720 |
| 16 | nuclear envelope disassembly (GO:0051081) | 4.16080720 |
| 17 | protein localization to chromosome, centromeric region (GO:0071459) | 4.10837109 |
| 18 | mitotic metaphase plate congression (GO:0007080) | 4.06602175 |
| 19 | regulation of histone methylation (GO:0031060) | 4.04250592 |
| 20 | negative regulation of histone methylation (GO:0031061) | 4.02222450 |
| 21 | regulation of female gonad development (GO:2000194) | 3.98761265 |
| 22 | histone H3-K4 trimethylation (GO:0080182) | 3.97773056 |
| 23 | sister chromatid segregation (GO:0000819) | 3.92777148 |
| 24 | N-terminal protein amino acid acetylation (GO:0006474) | 3.91404544 |
| 25 | regulation of sister chromatid cohesion (GO:0007063) | 3.90499658 |
| 26 | mitotic sister chromatid segregation (GO:0000070) | 3.89679021 |
| 27 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.88786865 |
| 28 | regulation of spindle organization (GO:0090224) | 3.82222805 |
| 29 | regulation of centriole replication (GO:0046599) | 3.80227706 |
| 30 | metaphase plate congression (GO:0051310) | 3.75486633 |
| 31 | regulation of histone H3-K9 methylation (GO:0051570) | 3.73661537 |
| 32 | kinetochore organization (GO:0051383) | 3.73465479 |
| 33 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.68432089 |
| 34 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.68432089 |
| 35 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.68432089 |
| 36 | histone H3-K4 methylation (GO:0051568) | 3.66979384 |
| 37 | oocyte development (GO:0048599) | 3.66704554 |
| 38 | regulation of RNA export from nucleus (GO:0046831) | 3.63601795 |
| 39 | positive regulation of chromosome segregation (GO:0051984) | 3.62939524 |
| 40 | meiotic cell cycle (GO:0051321) | 3.62078821 |
| 41 | cytoplasmic mRNA processing body assembly (GO:0033962) | 3.61129679 |
| 42 | histone H2A monoubiquitination (GO:0035518) | 3.56089062 |
| 43 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.54944627 |
| 44 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.54944627 |
| 45 | positive regulation of histone methylation (GO:0031062) | 3.53669999 |
| 46 | heterochromatin organization (GO:0070828) | 3.53544437 |
| 47 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.51301026 |
| 48 | regulation of mitotic spindle organization (GO:0060236) | 3.50607708 |
| 49 | meiotic chromosome segregation (GO:0045132) | 3.49804815 |
| 50 | protein localization to chromosome (GO:0034502) | 3.48174627 |
| 51 | DNA duplex unwinding (GO:0032508) | 3.46180774 |
| 52 | DNA geometric change (GO:0032392) | 3.45834891 |
| 53 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.45331924 |
| 54 | histone lysine demethylation (GO:0070076) | 3.44083839 |
| 55 | DNA replication checkpoint (GO:0000076) | 3.40998320 |
| 56 | centriole replication (GO:0007099) | 3.40005995 |
| 57 | establishment of chromosome localization (GO:0051303) | 3.37581042 |
| 58 | DNA replication initiation (GO:0006270) | 3.36319194 |
| 59 | peptidyl-lysine trimethylation (GO:0018023) | 3.34861767 |
| 60 | chromatin assembly or disassembly (GO:0006333) | 3.34253319 |
| 61 | chromatin assembly (GO:0031497) | 3.31259417 |
| 62 | histone H3-K9 demethylation (GO:0033169) | 3.30057649 |
| 63 | sister chromatid cohesion (GO:0007062) | 3.26578885 |
| 64 | kinetochore assembly (GO:0051382) | 3.26490568 |
| 65 | histone demethylation (GO:0016577) | 3.24567156 |
| 66 | regulation of chromosome segregation (GO:0051983) | 3.23633853 |
| 67 | nuclear envelope organization (GO:0006998) | 3.23199663 |
| 68 | stress granule assembly (GO:0034063) | 3.22670801 |
| 69 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.22208890 |
| 70 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.21358424 |
| 71 | DNA replication-independent nucleosome organization (GO:0034724) | 3.21358424 |
| 72 | positive regulation of gene expression, epigenetic (GO:0045815) | 3.19461329 |
| 73 | dosage compensation (GO:0007549) | 3.18287110 |
| 74 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 3.17913849 |
| 75 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 3.17913849 |
| 76 | regulation of translation, ncRNA-mediated (GO:0045974) | 3.17913849 |
| 77 | paraxial mesoderm development (GO:0048339) | 3.17070865 |
| 78 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla | 3.16352409 |
| 79 | gene silencing by RNA (GO:0031047) | 3.15960142 |
| 80 | chromosome segregation (GO:0007059) | 3.15191574 |
| 81 | DNA topological change (GO:0006265) | 3.14023080 |
| 82 | * negative regulation of histone modification (GO:0031057) | 3.10131027 |
| 83 | histone H3-K9 modification (GO:0061647) | 3.09676073 |
| 84 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.09365078 |
| 85 | negative regulation of DNA repair (GO:0045738) | 3.08671205 |
| 86 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.08247435 |
| 87 | chromatin remodeling at centromere (GO:0031055) | 3.07687299 |
| 88 | spindle checkpoint (GO:0031577) | 3.06666581 |
| 89 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.06478508 |
| 90 | DNA conformation change (GO:0071103) | 3.05766290 |
| 91 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.04676271 |
| 92 | protein K6-linked ubiquitination (GO:0085020) | 3.03989459 |
| 93 | regulation of DNA endoreduplication (GO:0032875) | 3.03870589 |
| 94 | regulation of meiosis I (GO:0060631) | 3.03166062 |
| 95 | nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289) | 3.03016743 |
| 96 | negative regulation of chromosome segregation (GO:0051985) | 3.01869072 |
| 97 | chromosome condensation (GO:0030261) | 2.97906765 |
| 98 | spindle assembly checkpoint (GO:0071173) | 2.97778179 |
| 99 | regulation of gene silencing by RNA (GO:0060966) | 2.97698126 |
| 100 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.97698126 |
| 101 | regulation of gene silencing by miRNA (GO:0060964) | 2.97698126 |
| 102 | DNA strand elongation (GO:0022616) | 2.96829388 |
| 103 | CENP-A containing nucleosome assembly (GO:0034080) | 2.96711820 |
| 104 | regulation of telomere maintenance via telomerase (GO:0032210) | 2.96558103 |
| 105 | DNA damage response, signal transduction resulting in transcription (GO:0042772) | 2.96377178 |
| 106 | positive regulation of DNA-dependent DNA replication (GO:2000105) | 2.96141254 |
| 107 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.96059120 |
| 108 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.95228199 |
| 109 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.95228199 |
| 110 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.95228199 |
| 111 | negative regulation of sister chromatid segregation (GO:0033046) | 2.95228199 |
| 112 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.94946075 |
| 113 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.94946075 |
| 114 | regulation of sister chromatid segregation (GO:0033045) | 2.94946075 |
| 115 | negative regulation of retinoic acid receptor signaling pathway (GO:0048387) | 2.94539630 |
| 116 | regulation of centrosome cycle (GO:0046605) | 2.94142533 |
| 117 | RNA stabilization (GO:0043489) | 2.94039738 |
| 118 | mRNA stabilization (GO:0048255) | 2.94039738 |
| 119 | nucleus organization (GO:0006997) | 2.93580729 |
| 120 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.93321918 |
| 121 | histone lysine methylation (GO:0034968) | 2.92753689 |
| 122 | glucocorticoid receptor signaling pathway (GO:0042921) | 2.92105410 |
| 123 | mitotic spindle assembly checkpoint (GO:0007094) | 2.91968265 |
| 124 | ATP-dependent chromatin remodeling (GO:0043044) | 2.91717244 |
| 125 | mitotic spindle checkpoint (GO:0071174) | 2.91484594 |
| 126 | spliceosomal tri-snRNP complex assembly (GO:0000244) | 2.89913891 |
| 127 | DNA packaging (GO:0006323) | 2.89295903 |
| 128 | protein dealkylation (GO:0008214) | 2.88391292 |
| 129 | protein demethylation (GO:0006482) | 2.88391292 |
| 130 | histone H3-K9 methylation (GO:0051567) | 2.87805918 |
| 131 | * negative regulation of chromatin modification (GO:1903309) | 2.87700845 |
| 132 | mRNA transport (GO:0051028) | 2.87221972 |
| 133 | histone H4-K12 acetylation (GO:0043983) | 2.86593042 |
| 134 | peptidyl-lysine methylation (GO:0018022) | 2.85638613 |
| 135 | regulation of histone H3-K27 methylation (GO:0061085) | 2.84163043 |
| 136 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.82967664 |
| 137 | regulation of nucleobase-containing compound transport (GO:0032239) | 2.82452074 |
| 138 | positive regulation of humoral immune response (GO:0002922) | 2.82108360 |
| 139 | gene silencing (GO:0016458) | 2.82047642 |
| 140 | histone exchange (GO:0043486) | 2.81733919 |
| 141 | DNA alkylation (GO:0006305) | 2.79534015 |
| 142 | DNA methylation (GO:0006306) | 2.79534015 |
| 143 | multicellular organism reproduction (GO:0032504) | 2.77552452 |
| 144 | V(D)J recombination (GO:0033151) | 2.74972799 |
| 145 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.72772235 |
| 146 | histone H4-K16 acetylation (GO:0043984) | 2.72695911 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 6.12928610 |
| 2 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.16386277 |
| 3 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.70529288 |
| 4 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.37928206 |
| 5 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 3.03506472 |
| 6 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.92440972 |
| 7 | * MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.85377465 |
| 8 | EZH2_22144423_ChIP-Seq_EOC_Human | 2.82001376 |
| 9 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.81499114 |
| 10 | MYC_22102868_ChIP-Seq_BL_Human | 2.61968720 |
| 11 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.50215978 |
| 12 | * E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.50104228 |
| 13 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.34925052 |
| 14 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 2.31025291 |
| 15 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.21342019 |
| 16 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.01856622 |
| 17 | * NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 2.01556561 |
| 18 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.9024185 |
| 19 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.99465665 |
| 20 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.97791016 |
| 21 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.96783089 |
| 22 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.95741307 |
| 23 | * MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.85563468 |
| 24 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.81177519 |
| 25 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.74468722 |
| 26 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.66256119 |
| 27 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.55568744 |
| 28 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.54421291 |
| 29 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.54244299 |
| 30 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.52626097 |
| 31 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.50915472 |
| 32 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.48295569 |
| 33 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.45117716 |
| 34 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.42763028 |
| 35 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.42359439 |
| 36 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.38566242 |
| 37 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.37259369 |
| 38 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.36169118 |
| 39 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.35743284 |
| 40 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.33553834 |
| 41 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.31093565 |
| 42 | * TCF7_22412390_ChIP-Seq_EML_Mouse | 1.31058515 |
| 43 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.28009833 |
| 44 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.26994698 |
| 45 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.26187456 |
| 46 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.26187456 |
| 47 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.26187456 |
| 48 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 1.26009573 |
| 49 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.25922829 |
| 50 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.25469179 |
| 51 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.24567110 |
| 52 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.21995352 |
| 53 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.21807500 |
| 54 | * VDR_21846776_ChIP-Seq_THP-1_Human | 1.21740168 |
| 55 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.21571166 |
| 56 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.20603471 |
| 57 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.20007300 |
| 58 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.14459556 |
| 59 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.14383641 |
| 60 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.13912421 |
| 61 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.12952401 |
| 62 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.12295023 |
| 63 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.10735649 |
| 64 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.09880859 |
| 65 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.09294490 |
| 66 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08815736 |
| 67 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.08260048 |
| 68 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.08045089 |
| 69 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.07723900 |
| 70 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.07039908 |
| 71 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.06459551 |
| 72 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.06006600 |
| 73 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.05384724 |
| 74 | * UTX_26944678_Chip-Seq_JUKART_Human | 1.04984313 |
| 75 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.04217305 |
| 76 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.03965247 |
| 77 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.03899726 |
| 78 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.02540046 |
| 79 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.01918953 |
| 80 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.01810532 |
| 81 | * MYB_26560356_Chip-Seq_TH1_Human | 1.01683653 |
| 82 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 1.01516391 |
| 83 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.01333849 |
| 84 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.00842063 |
| 85 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.00350047 |
| 86 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.00139612 |
| 87 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 0.99222246 |
| 88 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.98588788 |
| 89 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 0.98489695 |
| 90 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.96768939 |
| 91 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.96643051 |
| 92 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.96067721 |
| 93 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 0.95693279 |
| 94 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.95609159 |
| 95 | * TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.95556328 |
| 96 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.94954315 |
| 97 | FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human | 0.90190488 |
| 98 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.89898104 |
| 99 | SCL_19346495_ChIP-Seq_HPC-7_Human | 0.89760547 |
| 100 | EWS_26573619_Chip-Seq_HEK293_Human | 0.89272780 |
| 101 | * MAF_26560356_Chip-Seq_TH1_Human | 0.88909426 |
| 102 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.88835076 |
| 103 | MYB_26560356_Chip-Seq_TH2_Human | 0.88522348 |
| 104 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 0.88394831 |
| 105 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.88057614 |
| 106 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.87615160 |
| 107 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.87580233 |
| 108 | RUNX_20019798_ChIP-Seq_JUKART_Human | 0.87169748 |
| 109 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.86752287 |
| 110 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.86681667 |
| 111 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.86075896 |
| 112 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 0.84404654 |
| 113 | * FOXA1_26743006_Chip-Seq_LNCaP-abl_Human | 0.81526929 |
| 114 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 0.80687809 |
| 115 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.80373071 |
| 116 | * NCOR1_26117541_ChIP-Seq_K562_Human | 0.80277906 |
| 117 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.79836831 |
| 118 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.79546940 |
| 119 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 0.79051452 |
| 120 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 0.78916161 |
| 121 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.78857223 |
| 122 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.78357710 |
| 123 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.78122591 |
| 124 | GATA3_27048872_Chip-Seq_THYMUS_Human | 0.75083687 |
| 125 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.74555622 |
| 126 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.72881174 |
| 127 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.71664730 |
| 128 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.71664730 |
| 129 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.70969408 |
| 130 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.69748276 |
| 131 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.69037967 |
| 132 | * FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.66596370 |
| 133 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.64817361 |
| 134 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.64291533 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010094_abnormal_chromosome_stability | 4.05210519 |
| 2 | MP0003693_abnormal_embryo_hatching | 3.98848647 |
| 3 | MP0008057_abnormal_DNA_replication | 3.67317685 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.52619431 |
| 5 | MP0003077_abnormal_cell_cycle | 3.47422672 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 3.16665977 |
| 7 | MP0008877_abnormal_DNA_methylation | 3.03824465 |
| 8 | MP0010352_gastrointestinal_tract_polyps | 2.54607881 |
| 9 | MP0008007_abnormal_cellular_replicative | 2.52218621 |
| 10 | MP0008058_abnormal_DNA_repair | 2.51098919 |
| 11 | MP0000350_abnormal_cell_proliferation | 2.26182498 |
| 12 | MP0001730_embryonic_growth_arrest | 2.25844641 |
| 13 | MP0005076_abnormal_cell_differentiation | 2.19859814 |
| 14 | MP0010307_abnormal_tumor_latency | 2.19757599 |
| 15 | MP0003123_paternal_imprinting | 2.19248606 |
| 16 | MP0002396_abnormal_hematopoietic_system | 2.17379504 |
| 17 | MP0003121_genomic_imprinting | 1.91298942 |
| 18 | MP0001672_abnormal_embryogenesis/_devel | 1.85042021 |
| 19 | MP0005380_embryogenesis_phenotype | 1.85042021 |
| 20 | MP0002084_abnormal_developmental_patter | 1.79790752 |
| 21 | MP0004808_abnormal_hematopoietic_stem | 1.79663388 |
| 22 | MP0003890_abnormal_embryonic-extraembry | 1.78840256 |
| 23 | MP0001697_abnormal_embryo_size | 1.74087831 |
| 24 | MP0002085_abnormal_embryonic_tissue | 1.73623065 |
| 25 | MP0003984_embryonic_growth_retardation | 1.71345492 |
| 26 | MP0002088_abnormal_embryonic_growth/wei | 1.68354996 |
| 27 | MP0002877_abnormal_melanocyte_morpholog | 1.64547767 |
| 28 | MP0008932_abnormal_embryonic_tissue | 1.64333329 |
| 29 | MP0002086_abnormal_extraembryonic_tissu | 1.62115962 |
| 30 | MP0004197_abnormal_fetal_growth/weight/ | 1.56204738 |
| 31 | MP0000569_abnormal_digit_pigmentation | 1.55905995 |
| 32 | MP0003705_abnormal_hypodermis_morpholog | 1.55503870 |
| 33 | MP0003787_abnormal_imprinting | 1.52961986 |
| 34 | MP0005395_other_phenotype | 1.51361262 |
| 35 | MP0004264_abnormal_extraembryonic_tissu | 1.45881905 |
| 36 | * MP0002080_prenatal_lethality | 1.41786068 |
| 37 | MP0002138_abnormal_hepatobiliary_system | 1.40585395 |
| 38 | MP0009278_abnormal_bone_marrow | 1.37227778 |
| 39 | MP0003567_abnormal_fetal_cardiomyocyte | 1.37200978 |
| 40 | MP0005075_abnormal_melanosome_morpholog | 1.35963350 |
| 41 | MP0005397_hematopoietic_system_phenotyp | 1.35860414 |
| 42 | MP0001545_abnormal_hematopoietic_system | 1.35860414 |
| 43 | MP0000490_abnormal_crypts_of | 1.33853375 |
| 44 | MP0002210_abnormal_sex_determination | 1.31966103 |
| 45 | MP0004381_abnormal_hair_follicle | 1.31559097 |
| 46 | MP0010030_abnormal_orbit_morphology | 1.26691143 |
| 47 | MP0003786_premature_aging | 1.26005824 |
| 48 | MP0002019_abnormal_tumor_incidence | 1.25695528 |
| 49 | MP0002653_abnormal_ependyma_morphology | 1.21512428 |
| 50 | MP0003937_abnormal_limbs/digits/tail_de | 1.20063157 |
| 51 | MP0009672_abnormal_birth_weight | 1.19979519 |
| 52 | MP0001293_anophthalmia | 1.19567229 |
| 53 | MP0000313_abnormal_cell_death | 1.19546176 |
| 54 | MP0001849_ear_inflammation | 1.16550877 |
| 55 | MP0003763_abnormal_thymus_physiology | 1.16345259 |
| 56 | MP0006292_abnormal_olfactory_placode | 1.14991226 |
| 57 | MP0001915_intracranial_hemorrhage | 1.14653322 |
| 58 | MP0009703_decreased_birth_body | 1.10877357 |
| 59 | MP0000703_abnormal_thymus_morphology | 1.10802222 |
| 60 | MP0009053_abnormal_anal_canal | 1.10529205 |
| 61 | MP0001929_abnormal_gametogenesis | 1.09777373 |
| 62 | MP0001145_abnormal_male_reproductive | 1.09049473 |
| 63 | MP0002398_abnormal_bone_marrow | 1.04164422 |
| 64 | MP0000653_abnormal_sex_gland | 1.03207328 |
| 65 | MP0003718_maternal_effect | 1.00254526 |
| 66 | MP0010678_abnormal_skin_adnexa | 1.00107106 |
| 67 | MP0001119_abnormal_female_reproductive | 0.99744271 |
| 68 | MP0002166_altered_tumor_susceptibility | 0.97881584 |
| 69 | MP0002796_impaired_skin_barrier | 0.96950283 |
| 70 | MP0003183_abnormal_peptide_metabolism | 0.96828228 |
| 71 | MP0003566_abnormal_cell_adhesion | 0.96070292 |
| 72 | MP0002006_tumorigenesis | 0.95805552 |
| 73 | MP0004185_abnormal_adipocyte_glucose | 0.95271488 |
| 74 | MP0003935_abnormal_craniofacial_develop | 0.94530367 |
| 75 | MP0005394_taste/olfaction_phenotype | 0.93479828 |
| 76 | MP0005499_abnormal_olfactory_system | 0.93479828 |
| 77 | MP0002925_abnormal_cardiovascular_devel | 0.93475694 |
| 78 | MP0002009_preneoplasia | 0.92505062 |
| 79 | MP0000383_abnormal_hair_follicle | 0.91824063 |
| 80 | MP0002092_abnormal_eye_morphology | 0.91385645 |
| 81 | MP0005409_darkened_coat_color | 0.90313645 |
| 82 | MP0001873_stomach_inflammation | 0.90056362 |
| 83 | MP0000733_abnormal_muscle_development | 0.89571573 |
| 84 | MP0002161_abnormal_fertility/fecundity | 0.87220186 |
| 85 | MP0008789_abnormal_olfactory_epithelium | 0.86874873 |
| 86 | MP0002722_abnormal_immune_system | 0.84552474 |
| 87 | MP0003950_abnormal_plasma_membrane | 0.84018215 |
| 88 | MP0000432_abnormal_head_morphology | 0.83956345 |
| 89 | MP0000428_abnormal_craniofacial_morphol | 0.83674441 |
| 90 | MP0000537_abnormal_urethra_morphology | 0.83466878 |
| 91 | MP0003119_abnormal_digestive_system | 0.83456985 |
| 92 | MP0003300_gastrointestinal_ulcer | 0.83359281 |
| 93 | MP0000427_abnormal_hair_cycle | 0.83191200 |
| 94 | MP0005023_abnormal_wound_healing | 0.82068386 |
| 95 | MP0000689_abnormal_spleen_morphology | 0.81201859 |
| 96 | MP0003315_abnormal_perineum_morphology | 0.79817562 |
| 97 | MP0005621_abnormal_cell_physiology | 0.79769944 |
| 98 | MP0002089_abnormal_postnatal_growth/wei | 0.79084907 |
| 99 | MP0002254_reproductive_system_inflammat | 0.78156293 |
| 100 | MP0003943_abnormal_hepatobiliary_system | 0.77577477 |
| 101 | MP0002697_abnormal_eye_size | 0.77206935 |
| 102 | MP0001286_abnormal_eye_development | 0.76766916 |
| 103 | MP0003115_abnormal_respiratory_system | 0.76327656 |
| 104 | MP0009333_abnormal_splenocyte_physiolog | 0.75323433 |
| 105 | MP0003699_abnormal_female_reproductive | 0.74240593 |
| 106 | MP0000377_abnormal_hair_follicle | 0.74062015 |
| 107 | MP0008995_early_reproductive_senescence | 0.72324448 |
| 108 | MP0002233_abnormal_nose_morphology | 0.72155656 |
| 109 | MP0008961_abnormal_basal_metabolism | 0.71541615 |
| 110 | MP0005384_cellular_phenotype | 0.71471944 |
| 111 | MP0009697_abnormal_copulation | 0.70895756 |
| 112 | MP0000566_synostosis | 0.70571545 |
| 113 | MP0002111_abnormal_tail_morphology | 0.69814171 |
| 114 | MP0002429_abnormal_blood_cell | 0.69782911 |
| 115 | MP0004233_abnormal_muscle_weight | 0.69734798 |
| 116 | MP0010234_abnormal_vibrissa_follicle | 0.66455523 |
| 117 | MP0003698_abnormal_male_reproductive | 0.66223115 |
| 118 | MP0000266_abnormal_heart_morphology | 0.64855259 |
| 119 | MP0000477_abnormal_intestine_morphology | 0.63376266 |
| 120 | MP0000716_abnormal_immune_system | 0.63190309 |
| 121 | MP0001188_hyperpigmentation | 0.63186867 |
| 122 | MP0001800_abnormal_humoral_immune | 0.61996028 |
| 123 | MP0002075_abnormal_coat/hair_pigmentati | 0.61451478 |
| 124 | MP0000631_abnormal_neuroendocrine_gland | 0.59171904 |
| 125 | MP0003755_abnormal_palate_morphology | 0.58229317 |
| 126 | MP0003861_abnormal_nervous_system | 0.56991570 |
| 127 | MP0001784_abnormal_fluid_regulation | 0.56105043 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Chromsome breakage (HP:0040012) | 4.30977908 |
| 2 | Abnormality of the fingertips (HP:0001211) | 3.94271807 |
| 3 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.85091551 |
| 4 | Ependymoma (HP:0002888) | 3.52814915 |
| 5 | Volvulus (HP:0002580) | 3.47308441 |
| 6 | Medulloblastoma (HP:0002885) | 3.22177293 |
| 7 | Abnormality of chromosome stability (HP:0003220) | 3.05916078 |
| 8 | Ectopic kidney (HP:0000086) | 3.01793757 |
| 9 | Long eyelashes (HP:0000527) | 2.92762010 |
| 10 | Birth length less than 3rd percentile (HP:0003561) | 2.89203800 |
| 11 | Patellar aplasia (HP:0006443) | 2.85618255 |
| 12 | Short 4th metacarpal (HP:0010044) | 2.79806629 |
| 13 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.79806629 |
| 14 | Colon cancer (HP:0003003) | 2.78197024 |
| 15 | Papillary thyroid carcinoma (HP:0002895) | 2.76021532 |
| 16 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.70539917 |
| 17 | Abnormality of the labia minora (HP:0012880) | 2.70438689 |
| 18 | Astrocytoma (HP:0009592) | 2.69594768 |
| 19 | Abnormality of the astrocytes (HP:0100707) | 2.69594768 |
| 20 | Increased nuchal translucency (HP:0010880) | 2.69028972 |
| 21 | Selective tooth agenesis (HP:0001592) | 2.67742646 |
| 22 | Neoplasm of the oral cavity (HP:0100649) | 2.67376295 |
| 23 | Meckel diverticulum (HP:0002245) | 2.67102201 |
| 24 | Facial hemangioma (HP:0000329) | 2.64769997 |
| 25 | Prominent nose (HP:0000448) | 2.63762117 |
| 26 | Rhabdomyosarcoma (HP:0002859) | 2.63005537 |
| 27 | Abdominal situs inversus (HP:0003363) | 2.61035001 |
| 28 | Abnormality of abdominal situs (HP:0011620) | 2.61035001 |
| 29 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.58440890 |
| 30 | Myelodysplasia (HP:0002863) | 2.56216054 |
| 31 | Acute myeloid leukemia (HP:0004808) | 2.55499287 |
| 32 | Shawl scrotum (HP:0000049) | 2.53045665 |
| 33 | Abnormality of the ileum (HP:0001549) | 2.50901983 |
| 34 | Acute lymphatic leukemia (HP:0006721) | 2.45870225 |
| 35 | Capillary hemangiomas (HP:0005306) | 2.43984042 |
| 36 | Oligodactyly (hands) (HP:0001180) | 2.42553664 |
| 37 | Abnormality of the preputium (HP:0100587) | 2.41998123 |
| 38 | Trigonocephaly (HP:0000243) | 2.38038008 |
| 39 | Deviation of the thumb (HP:0009603) | 2.37914036 |
| 40 | Proximal placement of thumb (HP:0009623) | 2.34413544 |
| 41 | Sandal gap (HP:0001852) | 2.33947840 |
| 42 | Impulsivity (HP:0100710) | 2.31370025 |
| 43 | Abnormality of the carotid arteries (HP:0005344) | 2.28900236 |
| 44 | Neoplasm of striated muscle (HP:0009728) | 2.28513238 |
| 45 | Small intestinal stenosis (HP:0012848) | 2.28110144 |
| 46 | Duodenal stenosis (HP:0100867) | 2.28110144 |
| 47 | Gonadotropin excess (HP:0000837) | 2.27943990 |
| 48 | Cafe-au-lait spot (HP:0000957) | 2.24492276 |
| 49 | Agnosia (HP:0010524) | 2.24059404 |
| 50 | Glioma (HP:0009733) | 2.21328512 |
| 51 | Deep palmar crease (HP:0006191) | 2.19248148 |
| 52 | Gastrointestinal carcinoma (HP:0002672) | 2.19089167 |
| 53 | Malignant gastrointestinal tract tumors (HP:0006749) | 2.19089167 |
| 54 | Carpal bone hypoplasia (HP:0001498) | 2.19079226 |
| 55 | High anterior hairline (HP:0009890) | 2.19043171 |
| 56 | Biliary tract neoplasm (HP:0100574) | 2.12150591 |
| 57 | Heterotopia (HP:0002282) | 2.10286814 |
| 58 | Vertebral arch anomaly (HP:0008438) | 2.08669900 |
| 59 | Obsessive-compulsive behavior (HP:0000722) | 2.07054421 |
| 60 | Uterine leiomyosarcoma (HP:0002891) | 2.06711605 |
| 61 | Leiomyosarcoma (HP:0100243) | 2.06711605 |
| 62 | Urethral obstruction (HP:0000796) | 2.04549036 |
| 63 | Embryonal neoplasm (HP:0002898) | 2.04511773 |
| 64 | Amaurosis fugax (HP:0100576) | 2.03581064 |
| 65 | Abnormality of the duodenum (HP:0002246) | 2.02444377 |
| 66 | High pitched voice (HP:0001620) | 2.00856292 |
| 67 | Dysmetric saccades (HP:0000641) | 1.97819318 |
| 68 | Truncal obesity (HP:0001956) | 1.96806599 |
| 69 | Basal cell carcinoma (HP:0002671) | 1.96306424 |
| 70 | Overlapping toe (HP:0001845) | 1.95569476 |
| 71 | Lip pit (HP:0100267) | 1.95494516 |
| 72 | Abnormality of the 4th metacarpal (HP:0010012) | 1.95468497 |
| 73 | Clubbing of toes (HP:0100760) | 1.94289026 |
| 74 | Bladder neoplasm (HP:0009725) | 1.94239784 |
| 75 | Bladder carcinoma (HP:0002862) | 1.94239784 |
| 76 | Anal stenosis (HP:0002025) | 1.94015799 |
| 77 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 1.93889849 |
| 78 | Deep philtrum (HP:0002002) | 1.92680648 |
| 79 | Cutis marmorata (HP:0000965) | 1.90961123 |
| 80 | Hereditary nonpolyposis colorectal carcinoma (HP:0006716) | 1.90412535 |
| 81 | Broad thumb (HP:0011304) | 1.90319947 |
| 82 | Blepharitis (HP:0000498) | 1.89578585 |
| 83 | Sloping forehead (HP:0000340) | 1.89107081 |
| 84 | Hyperacusis (HP:0010780) | 1.87371753 |
| 85 | Narrow palate (HP:0000189) | 1.87161136 |
| 86 | Neoplasm of the adrenal cortex (HP:0100641) | 1.85851685 |
| 87 | Abnormal number of incisors (HP:0011064) | 1.85551373 |
| 88 | Sparse lateral eyebrow (HP:0005338) | 1.84539107 |
| 89 | Thyroid carcinoma (HP:0002890) | 1.84349549 |
| 90 | Broad palm (HP:0001169) | 1.84138764 |
| 91 | Absent radius (HP:0003974) | 1.83768403 |
| 92 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.83620951 |
| 93 | Tracheoesophageal fistula (HP:0002575) | 1.83385526 |
| 94 | Combined immunodeficiency (HP:0005387) | 1.83223639 |
| 95 | Missing ribs (HP:0000921) | 1.83208541 |
| 96 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.82965602 |
| 97 | Choanal atresia (HP:0000453) | 1.82609889 |
| 98 | Oligodactyly (HP:0012165) | 1.82124774 |
| 99 | Cystic hygroma (HP:0000476) | 1.81904800 |
| 100 | Premature ovarian failure (HP:0008209) | 1.81657368 |
| 101 | Abnormality of the phalanges of the hallux (HP:0010057) | 1.80240859 |
| 102 | Depressed nasal tip (HP:0000437) | 1.79332346 |
| 103 | Abnormality of chromosome segregation (HP:0002916) | 1.79168105 |
| 104 | Atresia of the external auditory canal (HP:0000413) | 1.79108735 |
| 105 | Rib fusion (HP:0000902) | 1.78147839 |
| 106 | IgA deficiency (HP:0002720) | 1.76148953 |
| 107 | Breast hypoplasia (HP:0003187) | 1.75932132 |
| 108 | Neoplasm of the pancreas (HP:0002894) | 1.74595626 |
| 109 | Skull defect (HP:0001362) | 1.74285114 |
| 110 | Aqueductal stenosis (HP:0002410) | 1.73040809 |
| 111 | Hypoplastic labia majora (HP:0000059) | 1.72604864 |
| 112 | Absent thumb (HP:0009777) | 1.72448926 |
| 113 | 11 pairs of ribs (HP:0000878) | 1.72314017 |
| 114 | Degeneration of anterior horn cells (HP:0002398) | 1.71920041 |
| 115 | Abnormality of the anterior horn cell (HP:0006802) | 1.71920041 |
| 116 | Diastasis recti (HP:0001540) | 1.71206863 |
| 117 | Short thumb (HP:0009778) | 1.70934506 |
| 118 | Reticulocytopenia (HP:0001896) | 1.68790865 |
| 119 | Cone-shaped epiphyses of the phalanges of the hand (HP:0010230) | 1.68455044 |
| 120 | Skin tags (HP:0010609) | 1.67961829 |
| 121 | Aplasia involving forearm bones (HP:0009822) | 1.67105149 |
| 122 | Absent forearm bone (HP:0003953) | 1.67105149 |
| 123 | Dislocated radial head (HP:0003083) | 1.66518709 |
| 124 | Abnormality of DNA repair (HP:0003254) | 1.66459418 |
| 125 | Supernumerary ribs (HP:0005815) | 1.65986259 |
| 126 | Bone marrow hypocellularity (HP:0005528) | 1.65958150 |
| 127 | Low anterior hairline (HP:0000294) | 1.64620120 |
| 128 | Renal cell carcinoma (HP:0005584) | 1.64511047 |
| 129 | Renal duplication (HP:0000075) | 1.63938257 |
| 130 | Embryonal renal neoplasm (HP:0011794) | 1.63872773 |
| 131 | IgM deficiency (HP:0002850) | 1.63834600 |
| 132 | Cortical dysplasia (HP:0002539) | 1.63007660 |
| 133 | Abnormal lung lobation (HP:0002101) | 1.62166015 |
| 134 | Subacute progressive viral hepatitis (HP:0006572) | 1.62133480 |
| 135 | Transitional cell carcinoma of the bladder (HP:0006740) | 1.61986880 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDK12 | 5.03354315 |
| 2 | CDC7 | 4.50267753 |
| 3 | LATS1 | 4.06973145 |
| 4 | EEF2K | 3.06174723 |
| 5 | NEK2 | 2.83086141 |
| 6 | MAP3K9 | 2.73981925 |
| 7 | TTK | 2.40468983 |
| 8 | MAP3K13 | 2.33512982 |
| 9 | WEE1 | 2.31544244 |
| 10 | SRPK1 | 2.08187611 |
| 11 | BRD4 | 2.06388479 |
| 12 | SMG1 | 2.01981944 |
| 13 | STK3 | 1.95920935 |
| 14 | RPS6KB2 | 1.83259254 |
| 15 | STK10 | 1.82542341 |
| 16 | MAP3K10 | 1.82224185 |
| 17 | LATS2 | 1.80382782 |
| 18 | PLK4 | 1.78885885 |
| 19 | CDK7 | 1.72156771 |
| 20 | ATR | 1.68644330 |
| 21 | CHEK2 | 1.62640572 |
| 22 | STK38L | 1.62612337 |
| 23 | CDK4 | 1.60163769 |
| 24 | PKN2 | 1.58546000 |
| 25 | NEK6 | 1.54305097 |
| 26 | PLK1 | 1.53324299 |
| 27 | AKT3 | 1.52030480 |
| 28 | CDK9 | 1.51497790 |
| 29 | BUB1 | 1.47670906 |
| 30 | AURKB | 1.45898218 |
| 31 | * CHEK1 | 1.44037759 |
| 32 | BRSK2 | 1.38054374 |
| 33 | TNIK | 1.36435424 |
| 34 | ACVR1B | 1.34422156 |
| 35 | EIF2AK3 | 1.33698511 |
| 36 | FGFR4 | 1.32637932 |
| 37 | ATM | 1.28502683 |
| 38 | PASK | 1.28477185 |
| 39 | MAP3K6 | 1.27358374 |
| 40 | MKNK2 | 1.25384843 |
| 41 | CAMK1D | 1.24519344 |
| 42 | TSSK6 | 1.24515545 |
| 43 | CDK6 | 1.23704158 |
| 44 | TRIM28 | 1.23129983 |
| 45 | NEK1 | 1.22027072 |
| 46 | MKNK1 | 1.21908214 |
| 47 | MELK | 1.21393806 |
| 48 | STK4 | 1.19885504 |
| 49 | TGFBR1 | 1.15952722 |
| 50 | MAP4K1 | 1.14338539 |
| 51 | MTOR | 1.14298108 |
| 52 | BRAF | 1.10664958 |
| 53 | STK24 | 1.07798188 |
| 54 | ICK | 1.07504255 |
| 55 | MAP3K8 | 1.07059840 |
| 56 | WNK1 | 1.06574701 |
| 57 | TAF1 | 1.06540190 |
| 58 | RPS6KA4 | 1.05480285 |
| 59 | FLT3 | 1.01443070 |
| 60 | * CDK2 | 1.00092923 |
| 61 | SIK3 | 0.99275451 |
| 62 | PLK3 | 0.99163726 |
| 63 | PRPF4B | 0.98503967 |
| 64 | SGK2 | 0.95561859 |
| 65 | TRIB3 | 0.94204057 |
| 66 | ALK | 0.87591476 |
| 67 | PIM1 | 0.86511412 |
| 68 | NUAK1 | 0.84801558 |
| 69 | TAOK3 | 0.83680654 |
| 70 | SGK3 | 0.82103026 |
| 71 | DYRK3 | 0.78699748 |
| 72 | CDK1 | 0.78553927 |
| 73 | EPHA2 | 0.75877057 |
| 74 | CDK8 | 0.74336609 |
| 75 | MAP3K14 | 0.73957804 |
| 76 | CAMK1G | 0.73089211 |
| 77 | CHUK | 0.72912080 |
| 78 | BRSK1 | 0.72685901 |
| 79 | TAOK1 | 0.68487288 |
| 80 | JAK3 | 0.65918242 |
| 81 | YES1 | 0.65061777 |
| 82 | PAK4 | 0.64643138 |
| 83 | PNCK | 0.63266368 |
| 84 | ZAK | 0.63092015 |
| 85 | SCYL2 | 0.61859641 |
| 86 | CSNK1D | 0.61195933 |
| 87 | FGFR3 | 0.58668610 |
| 88 | MAPKAPK3 | 0.57926206 |
| 89 | FGFR2 | 0.57123987 |
| 90 | MST4 | 0.56333529 |
| 91 | * MAPK14 | 0.55953906 |
| 92 | MAP2K3 | 0.54549392 |
| 93 | IRAK1 | 0.54363373 |
| 94 | PDGFRB | 0.54198447 |
| 95 | EIF2AK1 | 0.51427559 |
| 96 | LRRK2 | 0.51336716 |
| 97 | EIF2AK2 | 0.51300332 |
| 98 | BMPR1B | 0.50646997 |
| 99 | VRK1 | 0.50617671 |
| 100 | DMPK | 0.50358940 |
| 101 | PRKDC | 0.50097513 |
| 102 | RIPK1 | 0.49933808 |
| 103 | PRKCI | 0.47973611 |
| 104 | AKT1 | 0.47554962 |
| 105 | KSR2 | 0.45858719 |
| 106 | PDGFRA | 0.45461349 |
| 107 | AURKA | 0.45381351 |
| 108 | RAF1 | 0.45337349 |
| 109 | MAPK1 | 0.43506181 |
| 110 | ERBB4 | 0.42058569 |
| 111 | CAMK4 | 0.41158629 |
| 112 | BTK | 0.40917003 |
| 113 | * GSK3B | 0.40845641 |
| 114 | IKBKE | 0.40105370 |
| 115 | FGFR1 | 0.39615026 |
| 116 | MAP3K7 | 0.39250433 |
| 117 | PAK2 | 0.37851902 |
| 118 | PTK6 | 0.37460065 |
| 119 | TTN | 0.37275929 |
| 120 | NLK | 0.36947678 |
| 121 | CDK3 | 0.36519202 |
| 122 | CSNK1E | 0.36484668 |
| 123 | TRPM7 | 0.36177043 |
| 124 | KSR1 | 0.34634319 |
| 125 | KIT | 0.33910106 |
| 126 | MAPK11 | 0.30332601 |
| 127 | MARK3 | 0.29322110 |
| 128 | AKT2 | 0.29025170 |
| 129 | * CSNK2A2 | 0.28137100 |
| 130 | CLK1 | 0.27624937 |
| 131 | MAPK10 | 0.26442117 |
| 132 | RPS6KA1 | 0.26310217 |
| 133 | TESK2 | 0.26072946 |
| 134 | CSF1R | 0.25513828 |
| 135 | TYRO3 | 0.24756571 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 3.58948558 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.37805453 |
| 3 | Cell cycle_Homo sapiens_hsa04110 | 3.19323533 |
| 4 | RNA transport_Homo sapiens_hsa03013 | 2.88857695 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.77166327 |
| 6 | Homologous recombination_Homo sapiens_hsa03440 | 2.62196672 |
| 7 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.55915387 |
| 8 | Spliceosome_Homo sapiens_hsa03040 | 2.51048570 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 2.50820220 |
| 10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.28464828 |
| 11 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.18064342 |
| 12 | RNA degradation_Homo sapiens_hsa03018 | 2.17613441 |
| 13 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.13035800 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.93205921 |
| 15 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.90824727 |
| 16 | Basal transcription factors_Homo sapiens_hsa03022 | 1.80630403 |
| 17 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.60256721 |
| 18 | Lysine degradation_Homo sapiens_hsa00310 | 1.58197340 |
| 19 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.51417278 |
| 20 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.50338426 |
| 21 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.49806916 |
| 22 | RNA polymerase_Homo sapiens_hsa03020 | 1.44877998 |
| 23 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.38219989 |
| 24 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.30814744 |
| 25 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.26499027 |
| 26 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.26054348 |
| 27 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.25215478 |
| 28 | Adherens junction_Homo sapiens_hsa04520 | 1.23230485 |
| 29 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.22019104 |
| 30 | HTLV-I infection_Homo sapiens_hsa05166 | 1.20497955 |
| 31 | * Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.20161736 |
| 32 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.15775602 |
| 33 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.15072192 |
| 34 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.14070810 |
| 35 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.12851883 |
| 36 | Thyroid cancer_Homo sapiens_hsa05216 | 1.12504456 |
| 37 | Colorectal cancer_Homo sapiens_hsa05210 | 1.11517876 |
| 38 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.11354680 |
| 39 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.11019059 |
| 40 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.09392747 |
| 41 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.06956266 |
| 42 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.03619605 |
| 43 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.01321723 |
| 44 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.95130553 |
| 45 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.94725615 |
| 46 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.93464492 |
| 47 | Circadian rhythm_Homo sapiens_hsa04710 | 0.90766995 |
| 48 | Hepatitis B_Homo sapiens_hsa05161 | 0.86521598 |
| 49 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.85119019 |
| 50 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.84290499 |
| 51 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.83719502 |
| 52 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.82257712 |
| 53 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.81572535 |
| 54 | Endometrial cancer_Homo sapiens_hsa05213 | 0.81257995 |
| 55 | Viral myocarditis_Homo sapiens_hsa05416 | 0.79647906 |
| 56 | Measles_Homo sapiens_hsa05162 | 0.79469875 |
| 57 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.79412005 |
| 58 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.78959055 |
| 59 | Prostate cancer_Homo sapiens_hsa05215 | 0.77841014 |
| 60 | Influenza A_Homo sapiens_hsa05164 | 0.77392151 |
| 61 | * Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.77355788 |
| 62 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.75472231 |
| 63 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.74909405 |
| 64 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.74801752 |
| 65 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.72289677 |
| 66 | Pathways in cancer_Homo sapiens_hsa05200 | 0.70131214 |
| 67 | Glioma_Homo sapiens_hsa05214 | 0.69313092 |
| 68 | Apoptosis_Homo sapiens_hsa04210 | 0.67457668 |
| 69 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.66871132 |
| 70 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.64631406 |
| 71 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.61348748 |
| 72 | Hepatitis C_Homo sapiens_hsa05160 | 0.61295250 |
| 73 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.61114668 |
| 74 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.60408705 |
| 75 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.60314944 |
| 76 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.60065423 |
| 77 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.60034053 |
| 78 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.58426759 |
| 79 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.56781116 |
| 80 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.56319474 |
| 81 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.56168474 |
| 82 | Leishmaniasis_Homo sapiens_hsa05140 | 0.55980727 |
| 83 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.55201463 |
| 84 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.54877265 |
| 85 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.53457825 |
| 86 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.51709645 |
| 87 | Ribosome_Homo sapiens_hsa03010 | 0.48646336 |
| 88 | Shigellosis_Homo sapiens_hsa05131 | 0.47922772 |
| 89 | Purine metabolism_Homo sapiens_hsa00230 | 0.47831589 |
| 90 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.47348369 |
| 91 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.47173058 |
| 92 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.46936757 |
| 93 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.46215601 |
| 94 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.46206269 |
| 95 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.45943460 |
| 96 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.44926831 |
| 97 | Bladder cancer_Homo sapiens_hsa05219 | 0.44512820 |
| 98 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.43817315 |
| 99 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.42777978 |
| 100 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.42733701 |
| 101 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.42391269 |
| 102 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.42077026 |
| 103 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.41169341 |
| 104 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.40566140 |
| 105 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.40429772 |
| 106 | Legionellosis_Homo sapiens_hsa05134 | 0.40184403 |
| 107 | Insulin resistance_Homo sapiens_hsa04931 | 0.39610111 |
| 108 | Focal adhesion_Homo sapiens_hsa04510 | 0.38495270 |
| 109 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.37995061 |
| 110 | Melanoma_Homo sapiens_hsa05218 | 0.36798548 |
| 111 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.34676450 |
| 112 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.34606911 |
| 113 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.34479293 |
| 114 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.34454633 |
| 115 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.34219973 |
| 116 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.34161606 |
| 117 | Platelet activation_Homo sapiens_hsa04611 | 0.33868175 |
| 118 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.33716590 |
| 119 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.33714384 |
| 120 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.32117432 |
| 121 | Long-term potentiation_Homo sapiens_hsa04720 | 0.29229862 |

