SIN3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)4.67726726
2gonadal mesoderm development (GO:0007506)4.18390086
3synaptic vesicle docking involved in exocytosis (GO:0016081)4.08324032
4synaptonemal complex assembly (GO:0007130)4.06515853
5positive regulation of male gonad development (GO:2000020)3.94098120
6cytoskeletal anchoring at plasma membrane (GO:0007016)3.88010751
7regulation of meiosis I (GO:0060631)3.80009110
8histone H2A monoubiquitination (GO:0035518)3.78707495
9regulation of ARF protein signal transduction (GO:0032012)3.70934305
10dosage compensation (GO:0007549)3.70373480
11synaptonemal complex organization (GO:0070193)3.67264693
12mannose metabolic process (GO:0006013)3.65854519
13adherens junction assembly (GO:0034333)3.65423552
14semaphorin-plexin signaling pathway (GO:0071526)3.65287506
15formation of translation preinitiation complex (GO:0001731)3.63611301
16histone H4-K12 acetylation (GO:0043983)3.63337433
17DNA replication-dependent nucleosome organization (GO:0034723)3.54725046
18DNA replication-dependent nucleosome assembly (GO:0006335)3.54725046
19focal adhesion assembly (GO:0048041)3.49803477
20cell-substrate adherens junction assembly (GO:0007045)3.49803477
21heterochromatin organization (GO:0070828)3.32969479
22mitotic G1 DNA damage checkpoint (GO:0031571)3.28489830
23mitotic nuclear envelope disassembly (GO:0007077)3.28484638
24negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.27563774
25histone H4-K8 acetylation (GO:0043982)3.25660222
26histone H4-K5 acetylation (GO:0043981)3.25660222
27regulation of ARF GTPase activity (GO:0032312)3.25660196
28DNA methylation involved in gamete generation (GO:0043046)3.24650915
29ribosomal small subunit assembly (GO:0000028)3.22785541
30regulation of male gonad development (GO:2000018)3.21900987
31DNA unwinding involved in DNA replication (GO:0006268)3.21110894
32viral transcription (GO:0019083)3.17005347
33sex determination (GO:0007530)3.16825169
34gene silencing by RNA (GO:0031047)3.16615383
35cell-substrate junction assembly (GO:0007044)3.15810013
36nuclear pore organization (GO:0006999)3.14442151
37membrane disassembly (GO:0030397)3.12412535
38nuclear envelope disassembly (GO:0051081)3.12412535
39mitotic chromosome condensation (GO:0007076)3.12181630
40nodal signaling pathway (GO:0038092)3.11861288
41DNA strand elongation involved in DNA replication (GO:0006271)3.10991711
42maturation of SSU-rRNA (GO:0030490)3.10744822
43fusion of sperm to egg plasma membrane (GO:0007342)3.08456043
44peptidyl-lysine dimethylation (GO:0018027)3.08302441
45trophectodermal cell differentiation (GO:0001829)3.07684505
46endothelial tube morphogenesis (GO:0061154)3.07273119
47morphogenesis of an endothelium (GO:0003159)3.07273119
48cell-cell junction maintenance (GO:0045217)3.06905598
49translational termination (GO:0006415)3.06662089
50nuclear pore complex assembly (GO:0051292)3.06584846
51pre-miRNA processing (GO:0031054)3.06514849
52planar cell polarity pathway involved in neural tube closure (GO:0090179)3.06360256
53male meiosis (GO:0007140)3.06121493
54cerebellar granule cell differentiation (GO:0021707)3.05567947
55Golgi transport vesicle coating (GO:0048200)3.04983869
56COPI coating of Golgi vesicle (GO:0048205)3.04983869
57protein localization to endosome (GO:0036010)3.03552761
58regulation of gene silencing by RNA (GO:0060966)2.99514302
59regulation of posttranscriptional gene silencing (GO:0060147)2.99514302
60regulation of gene silencing by miRNA (GO:0060964)2.99514302
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.96512667
62positive regulation of synapse maturation (GO:0090129)2.95332205
63translational elongation (GO:0006414)2.93451971
64translesion synthesis (GO:0019985)2.91803435
65sodium ion export (GO:0071436)2.91695862
66mitotic G1/S transition checkpoint (GO:0044819)2.91280460
67anatomical structure regression (GO:0060033)2.89578385
68DNA strand elongation (GO:0022616)2.89394839
69regulation of NFAT protein import into nucleus (GO:0051532)2.88558529
70positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.86007855
71peptidyl-arginine omega-N-methylation (GO:0035247)2.84177514
72translational initiation (GO:0006413)2.83872284
73protein localization to kinetochore (GO:0034501)2.83652121
74sequestering of actin monomers (GO:0042989)2.82543484
75apoptotic process involved in morphogenesis (GO:0060561)2.82432196
76positive regulation of Rap GTPase activity (GO:0032854)2.81644572
77regulation of translational termination (GO:0006449)2.81627921
78regulation of chromatin binding (GO:0035561)2.80394661
79DNA replication initiation (GO:0006270)2.78294157
80positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76955710
81histone H2A acetylation (GO:0043968)2.76457558
82histone H2A ubiquitination (GO:0033522)2.73583653
83regulation of early endosome to late endosome transport (GO:2000641)2.73571361
84postreplication repair (GO:0006301)2.72556878
85insulin-like growth factor receptor signaling pathway (GO:0048009)2.72525649
86chromatin assembly (GO:0031497)2.72327409
87activation of Rac GTPase activity (GO:0032863)2.72249196
88folic acid-containing compound biosynthetic process (GO:0009396)2.72141457
89G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.71829049
90regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.71608296
91negative regulation of meiosis (GO:0045835)2.71336798
92meiotic nuclear division (GO:0007126)2.70231472
93antigen processing and presentation via MHC class Ib (GO:0002475)2.69332320
94Arp2/3 complex-mediated actin nucleation (GO:0034314)2.69282457
95protein targeting to plasma membrane (GO:0072661)2.69190899
96regulation of translational fidelity (GO:0006450)2.68412086
97glutamate secretion (GO:0014047)2.68406259
98cell migration in hindbrain (GO:0021535)2.67792699
99positive regulation of blood vessel endothelial cell migration (GO:0043536)2.66864933
100hepatocyte apoptotic process (GO:0097284)2.66485595
101gene silencing (GO:0016458)2.65609521
102stress fiber assembly (GO:0043149)2.64773948
103telomere maintenance via semi-conservative replication (GO:0032201)2.64089951
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.63725318
105signal complex assembly (GO:0007172)2.63413100
106peptidyl-tyrosine autophosphorylation (GO:0038083)2.62629674
107protein insertion into membrane (GO:0051205)2.62540507
108oocyte development (GO:0048599)2.62193493
109activation of JUN kinase activity (GO:0007257)2.61660433
110positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.61358804
111SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60122797
112positive regulation of histone deacetylation (GO:0031065)2.59849257
113positive regulation of receptor recycling (GO:0001921)2.59575030
114synaptic vesicle exocytosis (GO:0016079)2.59471121
115positive regulation of CREB transcription factor activity (GO:0032793)2.59422459
116negative regulation of cell size (GO:0045792)2.59396601
117endothelial cell chemotaxis (GO:0035767)2.59078852
118protein localization to chromosome, centromeric region (GO:0071459)2.59046693
119chromosome organization involved in meiosis (GO:0070192)2.58267829
120positive regulation of protein dephosphorylation (GO:0035307)2.56153115
121basement membrane organization (GO:0071711)2.56140738
122negative regulation of histone methylation (GO:0031061)2.54833044
123negative regulation of fatty acid transport (GO:2000192)2.53220534
124negative regulation of RNA splicing (GO:0033119)2.51325770
125viral life cycle (GO:0019058)2.50205411
126protein targeting to ER (GO:0045047)2.49934217
127regulation of synapse maturation (GO:0090128)2.49523170
128regulation of hippo signaling (GO:0035330)2.49207553
129nuclear envelope organization (GO:0006998)2.48497999
130protein complex disassembly (GO:0043241)2.47704804
131snRNA metabolic process (GO:0016073)2.47215765
132G1 DNA damage checkpoint (GO:0044783)2.46905254
133cotranslational protein targeting to membrane (GO:0006613)2.46682272
134vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.46475334
135negative regulation of myotube differentiation (GO:0010832)2.46097133
136regulation of DNA damage checkpoint (GO:2000001)2.45667383
137histone arginine methylation (GO:0034969)2.45602185
138locomotory exploration behavior (GO:0035641)2.44682033
139snRNA processing (GO:0016180)2.44622752
140regulation of G0 to G1 transition (GO:0070316)2.42959870
1413-UTR-mediated mRNA stabilization (GO:0070935)2.41913140
142synaptic vesicle maturation (GO:0016188)2.41698051
143interferon-gamma secretion (GO:0072643)2.41264121
144hemidesmosome assembly (GO:0031581)2.41127315
145negative regulation of erythrocyte differentiation (GO:0045647)2.40048957
146DNA methylation (GO:0006306)2.39699987
147DNA alkylation (GO:0006305)2.39699987
148amino acid import (GO:0043090)2.38728849
149activation of protein kinase A activity (GO:0034199)2.38385741
150telomere maintenance via recombination (GO:0000722)2.37971913
151cell junction maintenance (GO:0034331)2.37676852
152cellular protein complex disassembly (GO:0043624)2.37609961
153regulation of histone H3-K9 methylation (GO:0051570)2.36921188
154response to laminar fluid shear stress (GO:0034616)2.36587591
155mitotic recombination (GO:0006312)2.36573176
156histone H4 deacetylation (GO:0070933)2.35672539
157regulation of Rap GTPase activity (GO:0032317)2.35609774
158regulation of synaptic vesicle exocytosis (GO:2000300)2.35067206
159intracellular estrogen receptor signaling pathway (GO:0030520)2.33909717
160atrioventricular valve morphogenesis (GO:0003181)2.33523186
161negative regulation of Ras protein signal transduction (GO:0046580)2.32685579
162neuromuscular process controlling balance (GO:0050885)2.30262589
163regulation of short-term neuronal synaptic plasticity (GO:0048172)2.29933980
164cell communication by electrical coupling (GO:0010644)2.28942527
165thymic T cell selection (GO:0045061)2.28298993
166response to muramyl dipeptide (GO:0032495)2.26967967
167activation of MAPKKK activity (GO:0000185)2.26887534
168cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.25806231
169L-amino acid import (GO:0043092)2.23472058
170regulation of extracellular matrix disassembly (GO:0010715)2.23289366
171cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.22583642
172embryonic process involved in female pregnancy (GO:0060136)2.22221738
173negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.21967878
174barbed-end actin filament capping (GO:0051016)2.21804112
175layer formation in cerebral cortex (GO:0021819)2.21508322
176negative regulation of small GTPase mediated signal transduction (GO:0051058)2.21372549
177cortical actin cytoskeleton organization (GO:0030866)2.19173219
178negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.18679583
179negative regulation of cell killing (GO:0031342)2.18679583
180cellular response to monoamine stimulus (GO:0071868)2.17468896
181cellular response to catecholamine stimulus (GO:0071870)2.17468896
182protein retention in ER lumen (GO:0006621)2.16274867
183dopamine receptor signaling pathway (GO:0007212)2.15971574
184vascular endothelial growth factor signaling pathway (GO:0038084)2.15152167
185neuronal ion channel clustering (GO:0045161)2.13439197
186retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.12098020
187positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.11146350
188positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.09582523
189mating behavior (GO:0007617)2.09184682
190positive regulation of Cdc42 GTPase activity (GO:0043089)2.07643243
191epithelial cell differentiation involved in prostate gland development (GO:0060742)2.06640822
192regulation of glucose import in response to insulin stimulus (GO:2001273)2.06018118
193cell volume homeostasis (GO:0006884)2.05581012
194actin filament bundle organization (GO:0061572)2.05343061
195actin filament bundle assembly (GO:0051017)2.05343061
196cellular potassium ion homeostasis (GO:0030007)2.05279845
197neural tube development (GO:0021915)2.04969893
198regulation of Ras protein signal transduction (GO:0046578)2.04787735
199Rho protein signal transduction (GO:0007266)2.04515160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.12714838
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.58772861
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.32098266
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27812476
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.12896047
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.84658947
7MYC_22102868_ChIP-Seq_BL_Human2.66760548
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.66142206
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.65187825
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.61052986
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51716061
12KDM2B_26808549_Chip-Seq_K562_Human2.40596600
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22024459
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.05993990
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.95259917
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93450894
17* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.93312097
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91853227
19MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91136290
20XRN2_22483619_ChIP-Seq_HELA_Human1.90830075
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89910603
22VDR_21846776_ChIP-Seq_THP-1_Human1.89892809
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88799949
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87110229
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.86182815
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.83713196
27KDM2B_26808549_Chip-Seq_JURKAT_Human1.83650126
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76183287
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75122225
30* DROSHA_22980978_ChIP-Seq_HELA_Human1.73267703
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68050276
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.67233748
33* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66420033
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.66047186
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63009856
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.62558239
37SMC4_20622854_ChIP-Seq_HELA_Human1.62377658
38P68_20966046_ChIP-Seq_HELA_Human1.61521669
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59926538
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58926647
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58400447
42CIITA_25753668_ChIP-Seq_RAJI_Human1.58186877
43TCF7_22412390_ChIP-Seq_EML_Mouse1.57267206
44DCP1A_22483619_ChIP-Seq_HELA_Human1.54973067
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54392258
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.53557666
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53301185
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.51971189
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51488925
50* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49919200
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49827638
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47443305
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.47411362
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45988063
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45935809
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.45509001
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.45184615
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45129115
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44513428
60* GABP_19822575_ChIP-Seq_HepG2_Human1.44394431
61CREB1_26743006_Chip-Seq_LNCaP_Human1.43912046
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42296073
63* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41692949
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40831303
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40188513
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39204689
67KDM2B_26808549_Chip-Seq_DND41_Human1.39070296
68CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38803529
69* TET1_21451524_ChIP-Seq_MESCs_Mouse1.38792898
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38161390
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37635819
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.37476444
73RARB_27405468_Chip-Seq_BRAIN_Mouse1.37171605
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37043851
75KDM5A_27292631_Chip-Seq_BREAST_Human1.35899474
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34175940
77CTCF_27219007_Chip-Seq_Bcells_Human1.33788139
78DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33035202
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.32402902
80MAF_26560356_Chip-Seq_TH1_Human1.32394616
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32270977
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.31654859
83UTX_26944678_Chip-Seq_JUKART_Human1.31474945
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30000109
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29439748
86VDR_23849224_ChIP-Seq_CD4+_Human1.27917178
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27268778
88TFEB_21752829_ChIP-Seq_HELA_Human1.26378189
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26122970
90* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25749029
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25296047
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24644497
93TET1_21490601_ChIP-Seq_MESCs_Mouse1.22599764
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.21744423
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21587736
96TTF2_22483619_ChIP-Seq_HELA_Human1.20223944
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19717531
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19427892
99ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17714489
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17431060
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16916922
102ATF3_27146783_Chip-Seq_COLON_Human1.16391633
103* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16234788
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16150362
105RUNX1_27514584_Chip-Seq_MCF-7_Human1.16111048
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15604810
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13722951
108KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13323166
109FOXP3_21729870_ChIP-Seq_TREG_Human1.12734252
110ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12285501
111MAF_26560356_Chip-Seq_TH2_Human1.12252099
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.11118768
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10586148
114RACK7_27058665_Chip-Seq_MCF-7_Human1.10283313
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10141948
116RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10133306
117EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10133306
118AR_21909140_ChIP-Seq_LNCAP_Human1.10021358
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09518905
120ZNF263_19887448_ChIP-Seq_K562_Human1.08937777
121SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08874705
122FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08615690
123SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07985763
124TP63_22573176_ChIP-Seq_HFKS_Human1.07958734
125CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07870885
126HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06984981
127TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06722592
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06461256
129RNF2_27304074_Chip-Seq_ESCs_Mouse1.06020992
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06016170
131NCOR1_26117541_ChIP-Seq_K562_Human1.06006166
132THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05453852
133MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05157449
134LXR_22292898_ChIP-Seq_THP-1_Human1.04796939
135CLOCK_20551151_ChIP-Seq_293T_Human1.04206127
136TP53_23651856_ChIP-Seq_MEFs_Mouse1.03999612
137JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03104408
138NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03034980
139KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02986913
140RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02138761
141KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02119919
142SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02034854
143NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01981165
144TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01797200
145SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01528077
146ELF1_20517297_ChIP-Seq_JURKAT_Human1.00730022
147BCOR_27268052_Chip-Seq_Bcells_Human0.99572563
148OCT4_19829295_ChIP-Seq_ESCs_Human0.99538509
149RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98563142
150SPI1_23547873_ChIP-Seq_NB4_Human0.98440152
151EZH2_27294783_Chip-Seq_ESCs_Mouse0.98286128
152* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97515530
153SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96165717
154ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95839432
155BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95753244
156E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95655566
157VDR_24763502_ChIP-Seq_THP-1_Human0.95039434
158EZH2_22144423_ChIP-Seq_EOC_Human0.95002540
159SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94941831
160NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94921611
161CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94852029
162MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94674085
163OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94200988
164TP53_22127205_ChIP-Seq_IMR90_Human0.93948066
165YY1_21170310_ChIP-Seq_MESCs_Mouse0.93825518
166MYB_26560356_Chip-Seq_TH1_Human0.93753161
167KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92769170
168SPI1_23127762_ChIP-Seq_K562_Human0.92424897
169SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92279114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.60152755
2MP0008877_abnormal_DNA_methylation3.59842323
3MP0004858_abnormal_nervous_system2.91840738
4MP0003693_abnormal_embryo_hatching2.81788560
5MP0005409_darkened_coat_color2.68752116
6MP0003123_paternal_imprinting2.68651270
7MP0008260_abnormal_autophagy2.67775414
8MP0004957_abnormal_blastocyst_morpholog2.61495635
9MP0010352_gastrointestinal_tract_polyps2.58432155
10MP0008995_early_reproductive_senescence2.54877335
11MP0003705_abnormal_hypodermis_morpholog2.40694522
12MP0003329_amyloid_beta_deposits2.36726605
13MP0001348_abnormal_lacrimal_gland2.34706407
14MP0008007_abnormal_cellular_replicative2.28446763
15MP0006054_spinal_hemorrhage2.27260740
16MP0003111_abnormal_nucleus_morphology2.27069468
17MP0005377_hearing/vestibular/ear_phenot2.21608666
18MP0003878_abnormal_ear_physiology2.21608666
19* MP0003077_abnormal_cell_cycle2.20476765
20MP0003172_abnormal_lysosome_physiology2.17845025
21MP0010094_abnormal_chromosome_stability2.13156145
22MP0005076_abnormal_cell_differentiation2.07986368
23MP0005058_abnormal_lysosome_morphology2.06120649
24MP0009278_abnormal_bone_marrow1.99289757
25MP0000751_myopathy1.98143639
26MP0001730_embryonic_growth_arrest1.96550007
27MP0003786_premature_aging1.94938683
28MP0002653_abnormal_ependyma_morphology1.91749049
29MP0002249_abnormal_larynx_morphology1.83428259
30MP0003121_genomic_imprinting1.76901244
31MP0003566_abnormal_cell_adhesion1.74667312
32MP0000678_abnormal_parathyroid_gland1.72216471
33MP0002210_abnormal_sex_determination1.69159318
34MP0000003_abnormal_adipose_tissue1.67725761
35MP0004808_abnormal_hematopoietic_stem1.62293195
36MP0002086_abnormal_extraembryonic_tissu1.61259273
37MP0003436_decreased_susceptibility_to1.58923480
38MP0002877_abnormal_melanocyte_morpholog1.57165985
39MP0000350_abnormal_cell_proliferation1.56887067
40MP0004264_abnormal_extraembryonic_tissu1.56662115
41MP0010307_abnormal_tumor_latency1.53171740
42MP0005375_adipose_tissue_phenotype1.53110107
43MP0001929_abnormal_gametogenesis1.52691147
44MP0001145_abnormal_male_reproductive1.50266654
45MP0009333_abnormal_splenocyte_physiolog1.49098957
46MP0000767_abnormal_smooth_muscle1.48964130
47MP0003567_abnormal_fetal_cardiomyocyte1.47892235
48MP0001672_abnormal_embryogenesis/_devel1.46909576
49MP0005380_embryogenesis_phenotype1.46909576
50MP0005451_abnormal_body_composition1.45688061
51MP0001697_abnormal_embryo_size1.45665484
52MP0003984_embryonic_growth_retardation1.44974973
53MP0005666_abnormal_adipose_tissue1.44715200
54MP0003635_abnormal_synaptic_transmissio1.43760801
55MP0004185_abnormal_adipocyte_glucose1.43693294
56* MP0004197_abnormal_fetal_growth/weight/1.43150785
57MP0000858_altered_metastatic_potential1.43008902
58MP0002088_abnormal_embryonic_growth/wei1.42033478
59MP0003690_abnormal_glial_cell1.40596953
60MP0003879_abnormal_hair_cell1.39941638
61MP0002084_abnormal_developmental_patter1.38655167
62MP0006138_congestive_heart_failure1.38569364
63MP0002080_prenatal_lethality1.36202490
64MP0001545_abnormal_hematopoietic_system1.33744981
65MP0005397_hematopoietic_system_phenotyp1.33744981
66MP0004130_abnormal_muscle_cell1.32594757
67MP0005023_abnormal_wound_healing1.31752534
68MP0008569_lethality_at_weaning1.31564295
69MP0003122_maternal_imprinting1.29964831
70MP0002089_abnormal_postnatal_growth/wei1.29088410
71MP0003283_abnormal_digestive_organ1.26099543
72MP0003763_abnormal_thymus_physiology1.25819577
73MP0008058_abnormal_DNA_repair1.25233883
74MP0008932_abnormal_embryonic_tissue1.24319087
75MP0001915_intracranial_hemorrhage1.24241961
76MP0004272_abnormal_basement_membrane1.23309287
77MP0002019_abnormal_tumor_incidence1.22525616
78MP0003091_abnormal_cell_migration1.22380927
79MP0000579_abnormal_nail_morphology1.21110041
80MP0010368_abnormal_lymphatic_system1.20837040
81MP0002063_abnormal_learning/memory/cond1.20651220
82MP0003119_abnormal_digestive_system1.19134846
83MP0000490_abnormal_crypts_of1.18688690
84MP0000653_abnormal_sex_gland1.18606593
85MP0005623_abnormal_meninges_morphology1.16927763
86MP0005257_abnormal_intraocular_pressure1.16908462
87MP0003634_abnormal_glial_cell1.16151318
88MP0003453_abnormal_keratinocyte_physiol1.16094604
89MP0002085_abnormal_embryonic_tissue1.15926833
90MP0002396_abnormal_hematopoietic_system1.14747441
91MP0004270_analgesia1.14123288
92MP0005410_abnormal_fertilization1.13480483
93MP0001849_ear_inflammation1.13379691
94MP0000358_abnormal_cell_content/1.12250991
95MP0003303_peritoneal_inflammation1.12043774
96MP0000685_abnormal_immune_system1.12005927
97MP0003828_pulmonary_edema1.09861732
98MP0001502_abnormal_circadian_rhythm1.09465748
99* MP0002398_abnormal_bone_marrow1.08720387
100MP0000313_abnormal_cell_death1.08571326
101MP0005503_abnormal_tendon_morphology1.07959335
102MP0002160_abnormal_reproductive_system1.04278679
103MP0000537_abnormal_urethra_morphology1.04031200
104MP0002998_abnormal_bone_remodeling1.03308980
105MP0003448_altered_tumor_morphology1.03210636
106MP0000703_abnormal_thymus_morphology1.03196236
107MP0008438_abnormal_cutaneous_collagen1.02944008
108MP0001958_emphysema1.01742090
109MP0003315_abnormal_perineum_morphology1.01079487
110MP0004233_abnormal_muscle_weight1.00192979
111MP0001727_abnormal_embryo_implantation1.00005986
112MP0010630_abnormal_cardiac_muscle0.99129196
113MP0003300_gastrointestinal_ulcer0.98513515
114MP0003045_fibrosis0.98424979
115MP0009384_cardiac_valve_regurgitation0.97373062
116MP0003698_abnormal_male_reproductive0.95387852
117MP0000013_abnormal_adipose_tissue0.95029090
118MP0003183_abnormal_peptide_metabolism0.94985661
119MP0000604_amyloidosis0.94232386
120MP0000747_muscle_weakness0.93011397
121MP0005423_abnormal_somatic_nervous0.92053204
122MP0004087_abnormal_muscle_fiber0.91565737
123MP0005670_abnormal_white_adipose0.91437857
124MP0000566_synostosis0.90692233
125MP0004947_skin_inflammation0.89790325
126MP0002933_joint_inflammation0.88907021
127MP0002722_abnormal_immune_system0.88581422
128MP0000534_abnormal_ureter_morphology0.88048446
129MP0000428_abnormal_craniofacial_morphol0.87044480
130MP0003115_abnormal_respiratory_system0.86201598
131MP0002932_abnormal_joint_morphology0.86059970
132MP0000759_abnormal_skeletal_muscle0.85787213
133MP0008874_decreased_physiological_sensi0.85616659
134MP0000689_abnormal_spleen_morphology0.85428313
135MP0004381_abnormal_hair_follicle0.84275801
136MP0008057_abnormal_DNA_replication0.84202332
137MP0005384_cellular_phenotype0.83061546
138MP0002060_abnormal_skin_morphology0.83006896
139MP0004133_heterotaxia0.82455737
140MP0003279_aneurysm0.82352323
141MP0009780_abnormal_chondrocyte_physiolo0.82330973
142MP0002064_seizures0.82199025
143MP0009672_abnormal_birth_weight0.82112133
144MP0003866_abnormal_defecation0.81243218
145MP0002405_respiratory_system_inflammati0.80861729
146* MP0002429_abnormal_blood_cell0.80814137
147MP0005508_abnormal_skeleton_morphology0.79531412
148MP0001819_abnormal_immune_cell0.79056348
149MP0005621_abnormal_cell_physiology0.78989982
150MP0000920_abnormal_myelination0.78841014
151MP0003191_abnormal_cellular_cholesterol0.78599867
152MP0005389_reproductive_system_phenotype0.77962149
153MP0002420_abnormal_adaptive_immunity0.77588889
154MP0005275_abnormal_skin_tensile0.77314743
155MP0004510_myositis0.76704236
156MP0000733_abnormal_muscle_development0.76337424
157MP0002133_abnormal_respiratory_system0.76025761
158MP0005388_respiratory_system_phenotype0.76025761
159MP0001299_abnormal_eye_distance/0.75619716
160MP0001533_abnormal_skeleton_physiology0.74457233
161MP0005390_skeleton_phenotype0.74164244
162MP0002452_abnormal_antigen_presenting0.73947865
163MP0000467_abnormal_esophagus_morphology0.73339931
164MP0002925_abnormal_cardiovascular_devel0.72495877
165* MP0000716_abnormal_immune_system0.71898509
166MP0001614_abnormal_blood_vessel0.71556113
167MP0010030_abnormal_orbit_morphology0.70761273
168MP0002166_altered_tumor_susceptibility0.70737099
169MP0001851_eye_inflammation0.69672643
170MP0003942_abnormal_urinary_system0.67535573
171MP0003075_altered_response_to0.66466019
172MP0002796_impaired_skin_barrier0.65795688
173MP0002116_abnormal_craniofacial_bone0.65521585
174MP0009840_abnormal_foam_cell0.65440546

Predicted human phenotypes

RankGene SetZ-score
111 pairs of ribs (HP:0000878)4.75712285
2Obstructive sleep apnea (HP:0002870)4.52509045
3Selective tooth agenesis (HP:0001592)4.25633768
4Male infertility (HP:0003251)4.01623519
5Hand muscle atrophy (HP:0009130)3.86578015
6Hyperacusis (HP:0010780)3.76075261
7Missing ribs (HP:0000921)3.62156560
8Gonadal dysgenesis (HP:0000133)3.42844758
9Degeneration of anterior horn cells (HP:0002398)3.24376385
10Abnormality of the anterior horn cell (HP:0006802)3.24376385
11Upper limb amyotrophy (HP:0009129)3.21038199
12Distal upper limb amyotrophy (HP:0007149)3.21038199
13Metaphyseal cupping (HP:0003021)3.15431013
14Gonadotropin excess (HP:0000837)2.88294021
15Micronodular cirrhosis (HP:0001413)2.77552696
16Supranuclear gaze palsy (HP:0000605)2.76748155
17Muscle fibrillation (HP:0010546)2.75623938
18Sex reversal (HP:0012245)2.74014534
19Abnormal sex determination (HP:0012244)2.74014534
20Elevated erythrocyte sedimentation rate (HP:0003565)2.71765286
21Reticulocytopenia (HP:0001896)2.69898493
22Cerebral aneurysm (HP:0004944)2.67034240
23Premature rupture of membranes (HP:0001788)2.65890222
24Protrusio acetabuli (HP:0003179)2.65579651
25Mesangial abnormality (HP:0001966)2.64801988
26Ankle contracture (HP:0006466)2.63951534
27Bronchomalacia (HP:0002780)2.57771939
28Abnormality of the lower motor neuron (HP:0002366)2.53785519
29Bladder diverticulum (HP:0000015)2.53418413
30Abnormality of the calcaneus (HP:0008364)2.53118269
31Facial diplegia (HP:0001349)2.48760374
32Tongue fasciculations (HP:0001308)2.48571259
33Ependymoma (HP:0002888)2.47411323
34Neurofibrillary tangles (HP:0002185)2.46923835
35Mitral regurgitation (HP:0001653)2.46721702
36Renovascular hypertension (HP:0100817)2.44260446
37Renal duplication (HP:0000075)2.44017528
38Cutaneous melanoma (HP:0012056)2.43275599
39Disproportionate tall stature (HP:0001519)2.40295112
40Colon cancer (HP:0003003)2.39352752
41Broad metatarsal (HP:0001783)2.32946143
42Atrophy/Degeneration involving motor neurons (HP:0007373)2.32783669
43Cervical subluxation (HP:0003308)2.31331916
44Nasal polyposis (HP:0100582)2.31205319
45Ulnar bowing (HP:0003031)2.30770383
46Long palpebral fissure (HP:0000637)2.30694343
47Cerebral inclusion bodies (HP:0100314)2.30453613
48Distal lower limb amyotrophy (HP:0008944)2.29912467
49Basal cell carcinoma (HP:0002671)2.27905767
50Annular pancreas (HP:0001734)2.27485755
51Fragile skin (HP:0001030)2.24043407
52Poikiloderma (HP:0001029)2.23926484
53Atrophic scars (HP:0001075)2.23839608
54Abnormality of cells of the erythroid lineage (HP:0012130)2.23052358
55Lower limb amyotrophy (HP:0007210)2.23028596
56Testicular neoplasm (HP:0010788)2.22024756
57Elfin facies (HP:0004428)2.21432165
58Difficulty climbing stairs (HP:0003551)2.20330131
59Increased variability in muscle fiber diameter (HP:0003557)2.19985618
60Spinal muscular atrophy (HP:0007269)2.18316507
61Fatigue (HP:0012378)2.18146608
62Abnormality of the fingertips (HP:0001211)2.17713741
63Myopathic facies (HP:0002058)2.16952795
64Thrombocytosis (HP:0001894)2.16025642
65Abnormality of the nasal mucosa (HP:0000433)2.15965816
66Rectal prolapse (HP:0002035)2.15709098
67Secondary amenorrhea (HP:0000869)2.15692966
68Insomnia (HP:0100785)2.14253888
69Overriding aorta (HP:0002623)2.13608170
70Trismus (HP:0000211)2.12129971
71Turricephaly (HP:0000262)2.11872830
72Amyotrophic lateral sclerosis (HP:0007354)2.11384422
73Peritonitis (HP:0002586)2.09793708
74Biconcave vertebral bodies (HP:0004586)2.09198194
75Aneurysm (HP:0002617)2.09043554
76Thin bony cortex (HP:0002753)2.08537791
77Pelvic girdle muscle weakness (HP:0003749)2.05714898
78Broad face (HP:0000283)2.04754532
79Bowel diverticulosis (HP:0005222)2.04046804
80Aortic aneurysm (HP:0004942)2.03810707
81Bicuspid aortic valve (HP:0001647)2.03713759
82Abnormal number of erythroid precursors (HP:0012131)2.02459779
83Slender long bone (HP:0003100)2.02229892
84Germ cell neoplasia (HP:0100728)2.01808743
85Multiple enchondromatosis (HP:0005701)2.01443265
86Abnormality of the peritoneum (HP:0002585)2.01013477
87Megalocornea (HP:0000485)1.98809897
88Amaurosis fugax (HP:0100576)1.97476607
89Male pseudohermaphroditism (HP:0000037)1.97346090
90Pointed chin (HP:0000307)1.95841922
91Medulloblastoma (HP:0002885)1.95602818
92Aplastic anemia (HP:0001915)1.94693183
93Lymphangioma (HP:0100764)1.94579843
94Stridor (HP:0010307)1.93948646
95Genu recurvatum (HP:0002816)1.93262178
96Dislocated radial head (HP:0003083)1.92720194
97Ankle clonus (HP:0011448)1.92312917
98Onion bulb formation (HP:0003383)1.92234624
99Abnormal neuron morphology (HP:0012757)1.91844480
100Abnormality of the motor neurons (HP:0002450)1.91844480
101Neoplasm of the pancreas (HP:0002894)1.91699981
102Diminished motivation (HP:0000745)1.91620160
103Flat cornea (HP:0007720)1.91265716
104Mitral valve prolapse (HP:0001634)1.91048390
105Premature ovarian failure (HP:0008209)1.89263950
106Neuronal loss in central nervous system (HP:0002529)1.88662105
107Dysmetric saccades (HP:0000641)1.87580112
108Segmental peripheral demyelination/remyelination (HP:0003481)1.86431267
109Abnormality of the radial head (HP:0003995)1.86184409
110Azoospermia (HP:0000027)1.84849938
111Large eyes (HP:0001090)1.84828239
112Astrocytoma (HP:0009592)1.83006040
113Abnormality of the astrocytes (HP:0100707)1.83006040
114Achilles tendon contracture (HP:0001771)1.81937634
115Abnormality of male internal genitalia (HP:0000022)1.81606270
116Vascular tortuosity (HP:0004948)1.81358216
117Arterial tortuosity (HP:0005116)1.81207341
118Blue sclerae (HP:0000592)1.81003102
119Abnormal spermatogenesis (HP:0008669)1.80672444
120Thin ribs (HP:0000883)1.80492100
121Abnormality of skeletal muscle fiber size (HP:0012084)1.79661826
122Oral leukoplakia (HP:0002745)1.79198930
123Squamous cell carcinoma (HP:0002860)1.79122338
124Spinal rigidity (HP:0003306)1.77618764
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.77539195
126Dilatation of the ascending aorta (HP:0005111)1.76566876
127Diplopia (HP:0000651)1.75507406
128Abnormality of binocular vision (HP:0011514)1.75507406
129Flat acetabular roof (HP:0003180)1.75445972
130Fasciculations (HP:0002380)1.74878482
131Entropion (HP:0000621)1.74338019
132Abnormality of the musculature of the hand (HP:0001421)1.74207398
133Emphysema (HP:0002097)1.74141014
134Distal lower limb muscle weakness (HP:0009053)1.73979662
135Vertebral arch anomaly (HP:0008438)1.73841744
136Agnosia (HP:0010524)1.73096504
137Cellulitis (HP:0100658)1.71251861
138J-shaped sella turcica (HP:0002680)1.71052481
139Abnormality of the diencephalon (HP:0010662)1.70370253
140Wormian bones (HP:0002645)1.69441893
141Eczematoid dermatitis (HP:0000976)1.68971491
142Apathy (HP:0000741)1.68921030
143Polygenic inheritance (HP:0010982)1.68706433
144Increased nuchal translucency (HP:0010880)1.67924738
145Increased connective tissue (HP:0009025)1.67404854
146Centrally nucleated skeletal muscle fibers (HP:0003687)1.66337108
147Aortic dissection (HP:0002647)1.65983685
148Optic nerve coloboma (HP:0000588)1.65779815
149Shallow orbits (HP:0000586)1.65488189
150Shoulder girdle muscle weakness (HP:0003547)1.64563353
151Long eyelashes (HP:0000527)1.64551150
152Abnormality of the thoracic spine (HP:0100711)1.64494070
153Precocious puberty (HP:0000826)1.62987352
154Spinal canal stenosis (HP:0003416)1.62945746
155Abnormality of the musculature of the pelvis (HP:0001469)1.62773333
156Abnormality of the hip-girdle musculature (HP:0001445)1.62773333
157Mildly elevated creatine phosphokinase (HP:0008180)1.61821632
158Abnormality of the aortic arch (HP:0012303)1.61556466
159Joint laxity (HP:0001388)1.61538048
160Vertebral compression fractures (HP:0002953)1.61424824
161High pitched voice (HP:0001620)1.60789131
162Supernumerary nipples (HP:0002558)1.60729714
163Hemorrhage of the eye (HP:0011885)1.60654283
164Adenoma sebaceum (HP:0009720)1.59897540
165Angiofibromas (HP:0010615)1.59897540
166Hypercortisolism (HP:0001578)1.59783097
167Persistence of primary teeth (HP:0006335)1.59180437
168Hypoventilation (HP:0002791)1.58556653
169Arnold-Chiari malformation (HP:0002308)1.58053511
170Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57178159
171Increased IgE level (HP:0003212)1.54502049
172Rapidly progressive (HP:0003678)1.53962071
173Premature skin wrinkling (HP:0100678)1.53278494
174Abnormality of the Achilles tendon (HP:0005109)1.53160361
175Bowed forearm bones (HP:0003956)1.52311588
176Bowing of the arm (HP:0006488)1.52311588
177Neoplasm of the heart (HP:0100544)1.51945416
178Aortic regurgitation (HP:0001659)1.51925099
179Abnormality of the humeroradial joint (HP:0100744)1.51712814
180Ankyloglossia (HP:0010296)1.51351863
181Neonatal short-limb short stature (HP:0008921)1.51345312
182Aplasia of the phalanges of the hand (HP:0009802)1.50580051
183Aplasia involving bones of the extremities (HP:0009825)1.50580051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.02297032
2EEF2K3.18811895
3PRPF4B3.03021951
4CDK122.89736939
5PKN22.85228801
6SIK12.62610008
7TESK22.52646342
8SMG12.51634466
9TESK12.47769476
10RPS6KB22.41662363
11WEE12.25850778
12NEK22.24416026
13MAP3K102.19928912
14NME22.18935371
15SCYL22.12107740
16CDC72.07865344
17PLK42.07108511
18PAK41.98069423
19MARK21.95722739
20MAP3K111.87122371
21FGFR41.79723998
22ACVR1B1.78562081
23TYRO31.75198104
24SIK21.68770250
25MAP3K131.61212715
26NTRK11.59942800
27MAPKAPK31.56170092
28RPS6KA41.55448624
29BUB11.55181169
30PTK61.51394003
31CDC42BPA1.49149727
32RIPK41.44603918
33CDK71.42900411
34PASK1.41285802
35EPHA21.40576567
36LRRK21.39267079
37CDK41.36393681
38MAP3K31.36095093
39ICK1.33868387
40RIPK11.32247657
41MAP4K11.29796594
42TNK21.23688664
43MAP2K21.23541413
44CAMKK11.20697812
45MAP3K71.18639423
46PRKD31.17262662
47STK101.16560098
48LIMK11.16048891
49MAP3K81.15841190
50PDGFRA1.14325497
51MAP3K61.12660034
52TGFBR11.11854972
53ERN11.11597791
54MTOR1.09261482
55ZAP701.09068417
56ILK1.08330584
57MAP2K31.08113898
58STK381.05982796
59CDK91.04099462
60PAK60.99992634
61MAP3K90.98510271
62FLT30.97598151
63PDPK10.94646673
64KDR0.93125395
65ATR0.91650829
66PLK10.91584276
67MAPK120.90709516
68CAMK1D0.89569035
69KIT0.88607402
70NTRK30.86801392
71PDK30.85998281
72PDK40.85998281
73DAPK20.85470187
74ARAF0.84774770
75TBK10.84758390
76MAP3K10.84725336
77JAK30.83898169
78DYRK30.82750511
79RPS6KC10.82562409
80RPS6KL10.82562409
81NTRK20.81002081
82ALK0.79898558
83BLK0.79893610
84SGK30.79679479
85PRKCH0.78623132
86RET0.78063312
87LATS20.73573099
88TAOK10.73432691
89UHMK10.71913479
90HIPK20.71500268
91TTN0.71248034
92PAK20.71235841
93BMX0.70902873
94PDK10.69482966
95NEK10.69460312
96BTK0.68735471
97CDK60.67740402
98FES0.67628834
99PAK10.66663421
100CHEK10.66556940
101MATK0.66538974
102TTK0.66400496
103RPS6KA60.66330822
104WNK30.65878444
105AURKB0.65175459
106SIK30.64385837
107MAPK70.62705797
108PTK20.62557242
109BRD40.62117369
110NEK90.62091143
111EPHB10.61801176
112CAMK1G0.60195759
113FGFR30.60079831
114TLK10.59908590
115TAOK20.58543499
116MARK10.57150993
117WNK10.55783491
118EPHA40.55390462
119CAMK10.55319624
120CHEK20.54856884
121JAK10.53618610
122MAPK100.52863745
123CSF1R0.51758470
124PRKD10.51208513
125IRAK30.51094856
126SGK2230.50342386
127SGK4940.50342386
128SRPK10.50115399
129CDK20.48353513
130PTK2B0.48188897
131CSK0.47922983
132MAPK110.47847126
133DAPK30.47772228
134DDR20.47549250
135STK110.46964580
136PIM10.46951487
137DYRK1B0.46403986
138PRKCI0.46225964
139AURKA0.45659933
140CAMK40.44281911
141HCK0.43581510
142IRAK40.43276339
143GRK60.42799866
144IRAK20.41650827
145MOS0.41244563
146CDK50.39756932
147MAPK80.39685594
148BRAF0.39255761
149TYK20.38889773
150KSR20.37324493
151PRKD20.35869254
152CHUK0.35359960
153RPS6KA10.35107615
154STK40.34218576
155MAPKAPK20.33806307
156MAP2K10.33659357
157PDGFRB0.32901603
158BRSK10.31810409
159PRKG20.31417628
160RPS6KA20.30855243
161MARK30.29454199

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.28372590
2Mismatch repair_Homo sapiens_hsa034302.71336745
3Spliceosome_Homo sapiens_hsa030402.49499563
4RNA transport_Homo sapiens_hsa030132.45271979
5Ribosome_Homo sapiens_hsa030102.31497971
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22440969
7Base excision repair_Homo sapiens_hsa034102.10926867
8Proteasome_Homo sapiens_hsa030502.02344635
9Nucleotide excision repair_Homo sapiens_hsa034202.02219281
10Antigen processing and presentation_Homo sapiens_hsa046121.99126263
11Cell cycle_Homo sapiens_hsa041101.95098454
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.91200548
13mRNA surveillance pathway_Homo sapiens_hsa030151.72313865
14RNA polymerase_Homo sapiens_hsa030201.69436508
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.67720816
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63894515
17Long-term potentiation_Homo sapiens_hsa047201.50286858
18GnRH signaling pathway_Homo sapiens_hsa049121.49314892
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49005314
20Small cell lung cancer_Homo sapiens_hsa052221.48628930
21Phospholipase D signaling pathway_Homo sapiens_hsa040721.48456032
22Other glycan degradation_Homo sapiens_hsa005111.47768799
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46590193
24Thyroid cancer_Homo sapiens_hsa052161.36081107
25ErbB signaling pathway_Homo sapiens_hsa040121.35607688
26Homologous recombination_Homo sapiens_hsa034401.35167544
27p53 signaling pathway_Homo sapiens_hsa041151.34507378
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31791077
29Estrogen signaling pathway_Homo sapiens_hsa049151.30317704
30HTLV-I infection_Homo sapiens_hsa051661.29523203
31Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28512675
32Chronic myeloid leukemia_Homo sapiens_hsa052201.27435787
33Pyrimidine metabolism_Homo sapiens_hsa002401.27386153
34Epstein-Barr virus infection_Homo sapiens_hsa051691.27217980
35Shigellosis_Homo sapiens_hsa051311.26380338
36Viral carcinogenesis_Homo sapiens_hsa052031.25991514
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25274538
38Herpes simplex infection_Homo sapiens_hsa051681.25080853
39Choline metabolism in cancer_Homo sapiens_hsa052311.24722481
40Colorectal cancer_Homo sapiens_hsa052101.24273257
41Basal transcription factors_Homo sapiens_hsa030221.22326350
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22000580
43Acute myeloid leukemia_Homo sapiens_hsa052211.18309296
44One carbon pool by folate_Homo sapiens_hsa006701.17210943
45Synaptic vesicle cycle_Homo sapiens_hsa047211.14386789
46Legionellosis_Homo sapiens_hsa051341.11364184
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11034187
48Prion diseases_Homo sapiens_hsa050201.09147897
49Inositol phosphate metabolism_Homo sapiens_hsa005621.08684525
50Apoptosis_Homo sapiens_hsa042101.08528281
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06639882
52Insulin signaling pathway_Homo sapiens_hsa049101.06549096
53RNA degradation_Homo sapiens_hsa030181.05545037
54Viral myocarditis_Homo sapiens_hsa054161.05338779
55N-Glycan biosynthesis_Homo sapiens_hsa005101.04934536
56VEGF signaling pathway_Homo sapiens_hsa043701.01780014
57Gastric acid secretion_Homo sapiens_hsa049711.01492554
58Hippo signaling pathway_Homo sapiens_hsa043901.01207432
59Rap1 signaling pathway_Homo sapiens_hsa040151.01190773
60Notch signaling pathway_Homo sapiens_hsa043301.00275814
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99386446
62Toxoplasmosis_Homo sapiens_hsa051450.98939798
63Endometrial cancer_Homo sapiens_hsa052130.98588016
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.98347720
65Melanogenesis_Homo sapiens_hsa049160.98195506
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98104472
67Oocyte meiosis_Homo sapiens_hsa041140.95693318
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95552622
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.95174370
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94908414
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.94651136
72Cholinergic synapse_Homo sapiens_hsa047250.93386371
73Axon guidance_Homo sapiens_hsa043600.93321196
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91904445
75Primary immunodeficiency_Homo sapiens_hsa053400.91026381
76MAPK signaling pathway_Homo sapiens_hsa040100.90866500
77Fanconi anemia pathway_Homo sapiens_hsa034600.90167118
78Influenza A_Homo sapiens_hsa051640.89054271
79Focal adhesion_Homo sapiens_hsa045100.88524052
80TGF-beta signaling pathway_Homo sapiens_hsa043500.87846035
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.87183587
82Leishmaniasis_Homo sapiens_hsa051400.86956539
83Bladder cancer_Homo sapiens_hsa052190.85756914
84Hepatitis B_Homo sapiens_hsa051610.85616948
85Pancreatic cancer_Homo sapiens_hsa052120.85334225
86B cell receptor signaling pathway_Homo sapiens_hsa046620.85045973
87Adherens junction_Homo sapiens_hsa045200.84656172
88AMPK signaling pathway_Homo sapiens_hsa041520.84337925
89Oxytocin signaling pathway_Homo sapiens_hsa049210.83747842
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83516068
91MicroRNAs in cancer_Homo sapiens_hsa052060.83016222
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82995312
93Circadian entrainment_Homo sapiens_hsa047130.82753754
94Proteoglycans in cancer_Homo sapiens_hsa052050.82164408
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.82034945
96T cell receptor signaling pathway_Homo sapiens_hsa046600.81919331
97Dilated cardiomyopathy_Homo sapiens_hsa054140.80843101
98Gap junction_Homo sapiens_hsa045400.80270238
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80255214
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79855528
101mTOR signaling pathway_Homo sapiens_hsa041500.78678075
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77683700
103Non-small cell lung cancer_Homo sapiens_hsa052230.76518229
104Endocytosis_Homo sapiens_hsa041440.74815295
105Salmonella infection_Homo sapiens_hsa051320.74656066
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74536703
107Glutamatergic synapse_Homo sapiens_hsa047240.74490706
108Ras signaling pathway_Homo sapiens_hsa040140.73716572
109Cocaine addiction_Homo sapiens_hsa050300.72208028
110cAMP signaling pathway_Homo sapiens_hsa040240.71232119
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70999124
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.70976896
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70166182
114Type II diabetes mellitus_Homo sapiens_hsa049300.69862582
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.69800755
116Amphetamine addiction_Homo sapiens_hsa050310.69597522
117Hepatitis C_Homo sapiens_hsa051600.69151089
118Insulin secretion_Homo sapiens_hsa049110.67846333
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67800370
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67762962
121Long-term depression_Homo sapiens_hsa047300.67708711
122Osteoclast differentiation_Homo sapiens_hsa043800.67311346
123Measles_Homo sapiens_hsa051620.67014290
124Chemokine signaling pathway_Homo sapiens_hsa040620.66892771
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66014853
126Insulin resistance_Homo sapiens_hsa049310.65317793
127Pathways in cancer_Homo sapiens_hsa052000.65232171
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65041006
129Tight junction_Homo sapiens_hsa045300.64778624
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64660444
131Dopaminergic synapse_Homo sapiens_hsa047280.63327960
132Sulfur relay system_Homo sapiens_hsa041220.62584012
133HIF-1 signaling pathway_Homo sapiens_hsa040660.61805635
134Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60438869
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60349814
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59791938
137Systemic lupus erythematosus_Homo sapiens_hsa053220.58900818
138ECM-receptor interaction_Homo sapiens_hsa045120.58836135
139Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57171103
140Amoebiasis_Homo sapiens_hsa051460.56590434
141Non-homologous end-joining_Homo sapiens_hsa034500.54198032
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53016202
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52900981
144Platelet activation_Homo sapiens_hsa046110.52692139
145Prolactin signaling pathway_Homo sapiens_hsa049170.50091732
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.49699752
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.49375525
148Renal cell carcinoma_Homo sapiens_hsa052110.48992369
149Alcoholism_Homo sapiens_hsa050340.48989522
150TNF signaling pathway_Homo sapiens_hsa046680.48812055
151Dorso-ventral axis formation_Homo sapiens_hsa043200.48573717
152Prostate cancer_Homo sapiens_hsa052150.48032503
153Glioma_Homo sapiens_hsa052140.42209891
154Basal cell carcinoma_Homo sapiens_hsa052170.41950374
155Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40708099

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