SIPA1L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)5.10015578
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.46664394
3plasma membrane repair (GO:0001778)4.35072627
4negative regulation of potassium ion transmembrane transport (GO:1901380)4.14199694
5myofibril assembly (GO:0030239)4.10302965
6sarcomere organization (GO:0045214)4.05004192
7cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.87538290
8cell communication by electrical coupling (GO:0010644)3.70338610
9neuron recognition (GO:0008038)3.68411521
10cardiac ventricle formation (GO:0003211)3.53389722
11regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.51752888
12neuronal stem cell maintenance (GO:0097150)3.40392067
13mating behavior (GO:0007617)3.39377256
14establishment of nucleus localization (GO:0040023)3.37023319
15presynaptic membrane organization (GO:0097090)3.35128469
16cardiac muscle contraction (GO:0060048)3.32277232
17striatum development (GO:0021756)3.32170142
18substrate-independent telencephalic tangential migration (GO:0021826)3.28964094
19substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.28964094
20negative regulation of hormone biosynthetic process (GO:0032353)3.28742751
21cytoskeletal anchoring at plasma membrane (GO:0007016)3.27821287
22cardiac muscle cell development (GO:0055013)3.25609490
23adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.22423319
24cell communication involved in cardiac conduction (GO:0086065)3.21866474
25outflow tract septum morphogenesis (GO:0003148)3.14939074
26regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.14376054
27asymmetric protein localization (GO:0008105)3.13443131
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.12885629
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.12072565
30actomyosin structure organization (GO:0031032)3.11071997
31cardiac cell development (GO:0055006)3.10161465
32layer formation in cerebral cortex (GO:0021819)3.06136275
33ventricular cardiac muscle cell action potential (GO:0086005)3.05389723
34atrial septum morphogenesis (GO:0060413)3.04853976
35astrocyte development (GO:0014002)3.04634770
36cardiac muscle hypertrophy (GO:0003300)3.04154329
37heart trabecula formation (GO:0060347)3.03573700
38protein localization to endosome (GO:0036010)3.03321295
39regulation of membrane repolarization (GO:0060306)3.03060920
40heart valve formation (GO:0003188)3.00872537
41cell junction maintenance (GO:0034331)3.00083720
42regulation of sarcomere organization (GO:0060297)2.97988039
43adult heart development (GO:0007512)2.97399745
44axonal fasciculation (GO:0007413)2.96912133
45cellular response to catecholamine stimulus (GO:0071870)2.95326107
46cellular response to monoamine stimulus (GO:0071868)2.95326107
47locomotory exploration behavior (GO:0035641)2.95310997
48embryonic foregut morphogenesis (GO:0048617)2.94080977
49paraxial mesoderm development (GO:0048339)2.94038659
50cell migration in hindbrain (GO:0021535)2.90680288
51regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.89917582
52sodium ion export (GO:0071436)2.89797984
53regulation of the force of heart contraction (GO:0002026)2.89664319
54apical protein localization (GO:0045176)2.89586568
55negative regulation of striated muscle cell apoptotic process (GO:0010664)2.89259100
56striated muscle hypertrophy (GO:0014897)2.87983422
57limb bud formation (GO:0060174)2.87166330
58cardiac right ventricle morphogenesis (GO:0003215)2.82157134
59lateral sprouting from an epithelium (GO:0060601)2.82028907
60regulation of cardiac muscle cell contraction (GO:0086004)2.80605993
61negative regulation of potassium ion transport (GO:0043267)2.80543932
62regulation of cardioblast differentiation (GO:0051890)2.77230059
63stress fiber assembly (GO:0043149)2.76826449
64cerebellar granule cell differentiation (GO:0021707)2.76754059
65endocardial cushion morphogenesis (GO:0003203)2.75118171
66membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.74285116
67mesenchyme morphogenesis (GO:0072132)2.73695056
68cell-cell junction maintenance (GO:0045217)2.73414500
69phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.71012599
70lens fiber cell development (GO:0070307)2.70988132
71ventricular trabecula myocardium morphogenesis (GO:0003222)2.70011960
72ephrin receptor signaling pathway (GO:0048013)2.67796968
73positive regulation of cardiac muscle cell differentiation (GO:2000727)2.67094666
74vascular endothelial growth factor signaling pathway (GO:0038084)2.66265738
75Notch signaling involved in heart development (GO:0061314)2.65912699
76transmission of nerve impulse (GO:0019226)2.65609481
77synaptic vesicle maturation (GO:0016188)2.65363481
78negative regulation of hormone metabolic process (GO:0032351)2.65180064
79ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.64327196
80retinal ganglion cell axon guidance (GO:0031290)2.63958733
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63384993
82negative regulation of oligodendrocyte differentiation (GO:0048715)2.63381961
83adherens junction assembly (GO:0034333)2.62972023
84regulation of cardioblast proliferation (GO:0003264)2.62963957
85regulation of secondary heart field cardioblast proliferation (GO:0003266)2.62963957
86regulation of p38MAPK cascade (GO:1900744)2.62227163
87potassium ion import (GO:0010107)2.61935145
88peristalsis (GO:0030432)2.61049249
89relaxation of cardiac muscle (GO:0055119)2.60679886
90regulation of actin filament-based movement (GO:1903115)2.60381777
91presynaptic membrane assembly (GO:0097105)2.60139276
92response to monoamine (GO:0071867)2.60036127
93response to catecholamine (GO:0071869)2.60036127
94heart morphogenesis (GO:0003007)2.59470517
95artery development (GO:0060840)2.59079750
96cardiac conduction (GO:0061337)2.57116516
97cerebral cortex radially oriented cell migration (GO:0021799)2.56547784
98regulation of axon extension involved in axon guidance (GO:0048841)2.56050325
99nucleus localization (GO:0051647)2.55444189
100cardiac muscle tissue morphogenesis (GO:0055008)2.55327164
101dendritic spine morphogenesis (GO:0060997)2.55248681
102adult walking behavior (GO:0007628)2.55047215
103insulin-like growth factor receptor signaling pathway (GO:0048009)2.54936108
104neuron projection extension involved in neuron projection guidance (GO:1902284)2.54780816
105axon extension involved in axon guidance (GO:0048846)2.54780816
106positive regulation of cardiac muscle tissue development (GO:0055025)2.54242608
107positive regulation of potassium ion transport (GO:0043268)2.51327377
108cardiac muscle hypertrophy in response to stress (GO:0014898)2.50807465
109muscle hypertrophy in response to stress (GO:0003299)2.50807465
110cardiac muscle adaptation (GO:0014887)2.50807465
111cardiac muscle cell action potential involved in contraction (GO:0086002)2.50513319
112regulation of relaxation of muscle (GO:1901077)2.49657171
113negative regulation of axon guidance (GO:1902668)2.49280412
114positive regulation of synapse assembly (GO:0051965)2.48261994
115multicellular organismal signaling (GO:0035637)2.47951324
116regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.47900990
117hippo signaling (GO:0035329)2.47686632
118regulation of synapse structural plasticity (GO:0051823)2.46758454
119cardiac muscle cell action potential (GO:0086001)2.46639918
120epithelial cell-cell adhesion (GO:0090136)2.46390263
121cardiac septum morphogenesis (GO:0060411)2.46239124
122positive regulation of cardiac muscle tissue growth (GO:0055023)2.45385212
123membrane repolarization during action potential (GO:0086011)2.44588694
124actin-myosin filament sliding (GO:0033275)2.41434550
125muscle filament sliding (GO:0030049)2.41434550
126muscle hypertrophy (GO:0014896)2.40620113
127embryonic heart tube development (GO:0035050)2.39588271
128regulation of short-term neuronal synaptic plasticity (GO:0048172)2.39311966
129regulation of axon guidance (GO:1902667)2.39107653
130axon extension (GO:0048675)2.36240461
131striated muscle contraction (GO:0006941)2.35596082
132negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.35371771
133coronary vasculature morphogenesis (GO:0060977)2.35241351
134positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.35214527
135semaphorin-plexin signaling pathway (GO:0071526)2.35150401
136cardiac muscle cell proliferation (GO:0060038)2.35110772
137regulation of heart rate by cardiac conduction (GO:0086091)2.34806927
138positive regulation of axon extension (GO:0045773)2.34326236
139regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.34095581
140cell migration involved in sprouting angiogenesis (GO:0002042)2.32969629
141positive regulation of potassium ion transmembrane transport (GO:1901381)2.32798192
142cardiac chamber formation (GO:0003207)2.32529581
143regulation of potassium ion transmembrane transporter activity (GO:1901016)2.30752909
144muscle tissue morphogenesis (GO:0060415)2.29378043
145membrane repolarization (GO:0086009)2.28835944
146bundle of His cell to Purkinje myocyte communication (GO:0086069)2.28791524
147regulation of striated muscle contraction (GO:0006942)2.28050569
148NLS-bearing protein import into nucleus (GO:0006607)2.27675923
149regulation of NFAT protein import into nucleus (GO:0051532)2.26721422
150regulation of tight junction assembly (GO:2000810)2.24941915
151negative regulation of vascular permeability (GO:0043116)2.24277459
152cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.23973083
153regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.23323668
154regulation of ARF GTPase activity (GO:0032312)2.22607180
155cell-substrate adherens junction assembly (GO:0007045)2.22500164
156focal adhesion assembly (GO:0048041)2.22500164
157lymphangiogenesis (GO:0001946)2.21566744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.57131264
2* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.36291703
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32845465
4* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.32764692
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.27130947
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22418209
7* EP300_21415370_ChIP-Seq_HL-1_Mouse2.17832683
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16694620
9ZFP281_18757296_ChIP-ChIP_E14_Mouse2.00270739
10DROSHA_22980978_ChIP-Seq_HELA_Human2.00199542
11KDM2B_26808549_Chip-Seq_SUP-B15_Human1.99249186
12PIAS1_25552417_ChIP-Seq_VCAP_Human1.93815413
13KDM2B_26808549_Chip-Seq_K562_Human1.93090389
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.89761851
15EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86203560
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86203560
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80214871
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.80168980
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78791663
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77320021
21TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75813996
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74476802
23ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73943429
24ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67651023
25KDM2B_26808549_Chip-Seq_DND41_Human1.64644039
26TBX20_22080862_ChIP-Seq_HEART_Mouse1.64404773
27TBX20_22328084_ChIP-Seq_HEART_Mouse1.64404773
28* SMAD3_21741376_ChIP-Seq_EPCs_Human1.62703870
29TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60568424
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60504666
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60154690
32* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.58963684
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56491877
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.55132485
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53941273
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53640540
37WT1_25993318_ChIP-Seq_PODOCYTE_Human1.52255361
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.51138403
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49601226
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49238439
41ZNF263_19887448_ChIP-Seq_K562_Human1.48783444
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47855013
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47619571
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47588702
45* ISL1_27105846_Chip-Seq_CPCs_Mouse1.46811153
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46276496
47* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45663208
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.45540026
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45533132
50* RARB_27405468_Chip-Seq_BRAIN_Mouse1.43800403
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.42787735
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.40878083
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39810991
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39242562
55* SMAD4_21799915_ChIP-Seq_A2780_Human1.39211659
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.38879320
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38310657
58* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37765891
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37404032
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37255575
61LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36768859
62* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.36145549
63* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.35933062
64* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35849703
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.35746272
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.33483510
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33274258
68TAF15_26573619_Chip-Seq_HEK293_Human1.33190760
69MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32286743
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.32234575
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.32007743
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29909470
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29513624
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28234556
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28234556
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27864688
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27081194
78HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26362965
79* AHR_22903824_ChIP-Seq_MCF-7_Human1.25590125
80P300_19829295_ChIP-Seq_ESCs_Human1.25496347
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.24429041
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24105252
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23948011
84RING1B_27294783_Chip-Seq_NPCs_Mouse1.23650283
85RNF2_27304074_Chip-Seq_NSC_Mouse1.23592221
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.20471845
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20152251
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18729344
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.18668157
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18258976
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.17698760
92SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17594508
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15655792
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15468485
95TP53_16413492_ChIP-PET_HCT116_Human1.14635447
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12702486
97TP63_17297297_ChIP-ChIP_HaCaT_Human1.12385587
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.12128960
99* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11063145
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10819565
101* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10404535
102* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10404535
103* SMAD3_21741376_ChIP-Seq_HESCs_Human1.10392595
104RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10317366
105* ARNT_22903824_ChIP-Seq_MCF-7_Human1.09837795
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.09198099
107TCF7_22412390_ChIP-Seq_EML_Mouse1.09000008
108CLOCK_20551151_ChIP-Seq_293T_Human1.08919464
109STAT3_23295773_ChIP-Seq_U87_Human1.08816442
110CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08375970
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07751772
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07008588
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06982558
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06640244
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06538531
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05361235
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04943782
118SALL1_21062744_ChIP-ChIP_HESCs_Human1.04434377
119* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04182437
120* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03670047
121ZNF274_21170338_ChIP-Seq_K562_Hela1.03646514
122AR_19668381_ChIP-Seq_PC3_Human1.03274225
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02837309
124RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02611250
125* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02071565
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01922225
127* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01486849
128RUNX1_27514584_Chip-Seq_MCF-7_Human1.01186529
129LXR_22292898_ChIP-Seq_THP-1_Human1.01181232
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00366296
131SMAD3_21741376_ChIP-Seq_ESCs_Human1.00315419
132CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99737557
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99471655
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99375119
135BCAT_22108803_ChIP-Seq_LS180_Human0.98994824
136NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98668730
137AR_25329375_ChIP-Seq_VCAP_Human0.98604346
138NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98502110
139* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98150587
140EGR1_19374776_ChIP-ChIP_THP-1_Human0.97426179
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.97177466
142FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.96604600
143HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96309090
144* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95825279
145RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95353073
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.94746292
147CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.94439374
148GBX2_23144817_ChIP-Seq_PC3_Human0.93519268
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92465246
150REST_21632747_ChIP-Seq_MESCs_Mouse0.92066556
151CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91982856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.10619341
2MP0004084_abnormal_cardiac_muscle4.24217914
3MP0000751_myopathy3.34958317
4MP0002837_dystrophic_cardiac_calcinosis3.25281663
5MP0005623_abnormal_meninges_morphology3.19943754
6MP0003136_yellow_coat_color2.95626091
7MP0004215_abnormal_myocardial_fiber2.82133912
8MP0004859_abnormal_synaptic_plasticity2.76515370
9MP0003705_abnormal_hypodermis_morpholog2.54031511
10MP0004036_abnormal_muscle_relaxation2.52043820
11MP0005248_abnormal_Harderian_gland2.44455858
12MP0004272_abnormal_basement_membrane2.43162734
13MP0010030_abnormal_orbit_morphology2.34074243
14MP0006138_congestive_heart_failure2.19199884
15MP0005330_cardiomyopathy2.18685965
16MP0000569_abnormal_digit_pigmentation2.14074308
17MP0003646_muscle_fatigue2.12088954
18MP0002972_abnormal_cardiac_muscle2.09806774
19MP0004087_abnormal_muscle_fiber2.07741107
20MP0010630_abnormal_cardiac_muscle2.04936792
21MP0003137_abnormal_impulse_conducting2.00094288
22MP0004484_altered_response_of2.00092208
23MP0005167_abnormal_blood-brain_barrier1.92480230
24MP0008775_abnormal_heart_ventricle1.92066014
25MP0003279_aneurysm1.83237942
26MP0005385_cardiovascular_system_phenoty1.82271314
27MP0001544_abnormal_cardiovascular_syste1.82271314
28MP0004085_abnormal_heartbeat1.79667031
29MP0004233_abnormal_muscle_weight1.74303617
30MP0010368_abnormal_lymphatic_system1.73164951
31MP0003566_abnormal_cell_adhesion1.73130136
32MP0004858_abnormal_nervous_system1.72908383
33MP0003828_pulmonary_edema1.72216483
34MP0000749_muscle_degeneration1.70981734
35MP0005620_abnormal_muscle_contractility1.67137835
36MP0004510_myositis1.64826451
37MP0003890_abnormal_embryonic-extraembry1.62394240
38MP0000750_abnormal_muscle_regeneration1.58713065
39MP0002822_catalepsy1.55632750
40MP0004130_abnormal_muscle_cell1.54893842
41MP0005076_abnormal_cell_differentiation1.47548023
42MP0000955_abnormal_spinal_cord1.45723246
43MP0004145_abnormal_muscle_electrophysio1.45479077
44MP0005409_darkened_coat_color1.44572331
45MP0003091_abnormal_cell_migration1.44402392
46MP0009053_abnormal_anal_canal1.42472984
47MP0002106_abnormal_muscle_physiology1.40829174
48MP0002653_abnormal_ependyma_morphology1.39958731
49MP0002269_muscular_atrophy1.39461903
50MP0001984_abnormal_olfaction1.39119276
51MP0002102_abnormal_ear_morphology1.39098915
52MP0003119_abnormal_digestive_system1.36412706
53MP0002127_abnormal_cardiovascular_syste1.34506126
54MP0009278_abnormal_bone_marrow1.34336487
55MP0003567_abnormal_fetal_cardiomyocyte1.33163451
56MP0000462_abnormal_digestive_system1.33129552
57MP0002249_abnormal_larynx_morphology1.31303524
58MP0003045_fibrosis1.29785903
59MP0003938_abnormal_ear_development1.29220211
60MP0002697_abnormal_eye_size1.28167708
61MP0004270_analgesia1.26748518
62MP0003122_maternal_imprinting1.26610869
63MP0005171_absent_coat_pigmentation1.26208333
64MP0003937_abnormal_limbs/digits/tail_de1.25056932
65MP0002233_abnormal_nose_morphology1.24682440
66MP0002184_abnormal_innervation1.24642856
67MP0000733_abnormal_muscle_development1.24640291
68MP0000747_muscle_weakness1.24261191
69MP0000767_abnormal_smooth_muscle1.23076682
70MP0001879_abnormal_lymphatic_vessel1.22504125
71MP0002925_abnormal_cardiovascular_devel1.22183852
72MP0003635_abnormal_synaptic_transmissio1.22062078
73MP0000266_abnormal_heart_morphology1.20501361
74MP0004185_abnormal_adipocyte_glucose1.19101337
75MP0005369_muscle_phenotype1.17814146
76MP0003329_amyloid_beta_deposits1.17197237
77MP0008438_abnormal_cutaneous_collagen1.16553379
78MP0003942_abnormal_urinary_system1.15540663
79MP0000778_abnormal_nervous_system1.15468774
80MP0000759_abnormal_skeletal_muscle1.13895250
81MP0001293_anophthalmia1.13627766
82MP0004885_abnormal_endolymph1.12506849
83MP0003221_abnormal_cardiomyocyte_apopto1.10493734
84MP0000534_abnormal_ureter_morphology1.10204997
85MP0008961_abnormal_basal_metabolism1.09737685
86MP0000026_abnormal_inner_ear1.08334404
87MP0002734_abnormal_mechanical_nocicepti1.05625041
88MP0003385_abnormal_body_wall1.05171642
89MP0001286_abnormal_eye_development1.04573762
90MP0003787_abnormal_imprinting1.03703597
91MP0005666_abnormal_adipose_tissue1.02974332
92MP0005423_abnormal_somatic_nervous1.01117697
93MP0009780_abnormal_chondrocyte_physiolo1.00145263
94MP0002638_abnormal_pupillary_reflex0.99287134
95MP0000428_abnormal_craniofacial_morphol0.98791373
96MP0000049_abnormal_middle_ear0.97586000
97MP0005670_abnormal_white_adipose0.97424277
98MP0003303_peritoneal_inflammation0.97293653
99MP0001958_emphysema0.97064864
100MP0001486_abnormal_startle_reflex0.96863616
101MP0002332_abnormal_exercise_endurance0.96691767
102MP0003950_abnormal_plasma_membrane0.96361393
103MP0002128_abnormal_blood_circulation0.95151957
104MP0003632_abnormal_nervous_system0.94240760
105MP0000537_abnormal_urethra_morphology0.92537725
106MP0005187_abnormal_penis_morphology0.91802567
107MP0009250_abnormal_appendicular_skeleto0.90969348
108MP0002882_abnormal_neuron_morphology0.90614719
109MP0002751_abnormal_autonomic_nervous0.89938035
110MP0005375_adipose_tissue_phenotype0.89095959
111MP0002735_abnormal_chemical_nociception0.87989836
112MP0002063_abnormal_learning/memory/cond0.87561634
113MP0003115_abnormal_respiratory_system0.87128326
114MP0003755_abnormal_palate_morphology0.86515488
115MP0002932_abnormal_joint_morphology0.86282122
116MP0002064_seizures0.85950712
117MP0001614_abnormal_blood_vessel0.84974121
118MP0003283_abnormal_digestive_organ0.82938529
119MP0001485_abnormal_pinna_reflex0.82469669
120MP0000579_abnormal_nail_morphology0.82460349
121MP0001849_ear_inflammation0.82125137
122MP0002282_abnormal_trachea_morphology0.80979371
123MP0002092_abnormal_eye_morphology0.80889768
124MP0003984_embryonic_growth_retardation0.80738174
125MP0002116_abnormal_craniofacial_bone0.80727813
126MP0002088_abnormal_embryonic_growth/wei0.80571872
127MP0001784_abnormal_fluid_regulation0.79408487
128MP0003935_abnormal_craniofacial_develop0.79367504
129MP0001915_intracranial_hemorrhage0.77852728
130MP0002108_abnormal_muscle_morphology0.77842258
131MP0000003_abnormal_adipose_tissue0.77161738
132MP0000432_abnormal_head_morphology0.76313351
133MP0004811_abnormal_neuron_physiology0.75523330
134MP0002909_abnormal_adrenal_gland0.74730628
135MP0005197_abnormal_uvea_morphology0.74392572
136MP0003941_abnormal_skin_development0.74181044
137MP0009046_muscle_twitch0.74092894
138MP0010352_gastrointestinal_tract_polyps0.73945713
139MP0003121_genomic_imprinting0.73802785
140MP0009384_cardiac_valve_regurgitation0.73550819
141MP0003634_abnormal_glial_cell0.73383680
142MP0003861_abnormal_nervous_system0.72746675
143MP0010234_abnormal_vibrissa_follicle0.72461298
144MP0002152_abnormal_brain_morphology0.72004250
145MP0000631_abnormal_neuroendocrine_gland0.71722079
146MP0005508_abnormal_skeleton_morphology0.70708452
147MP0002084_abnormal_developmental_patter0.68654807
148MP0002234_abnormal_pharynx_morphology0.68184303
149MP0005380_embryogenesis_phenotype0.67010642
150MP0001672_abnormal_embryogenesis/_devel0.67010642

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.77749098
2Cerebral aneurysm (HP:0004944)4.22145139
3Ventricular tachycardia (HP:0004756)3.71305085
4Atrial fibrillation (HP:0005110)3.69841749
5Abnormal pancreas size (HP:0012094)3.63892876
6Oligodactyly (hands) (HP:0001180)3.61129003
7Primary atrial arrhythmia (HP:0001692)3.50595397
8Split foot (HP:0001839)3.43709549
9Supraventricular arrhythmia (HP:0005115)3.31834333
10Supraventricular tachycardia (HP:0004755)3.27087278
11Hypoplastic pelvis (HP:0008839)3.24520746
12Bundle branch block (HP:0011710)3.24343183
13Hyporeflexia of lower limbs (HP:0002600)3.24074351
14Muscle fiber splitting (HP:0003555)3.22706391
15Syncope (HP:0001279)3.14477940
16Right ventricular cardiomyopathy (HP:0011663)3.08720180
17Exercise-induced muscle cramps (HP:0003710)3.07838236
18Difficulty running (HP:0009046)3.05571316
19Shallow orbits (HP:0000586)2.96963115
20Anophthalmia (HP:0000528)2.88344383
21Ventricular fibrillation (HP:0001663)2.88106595
22Abnormality of the pubic bones (HP:0003172)2.86249260
23Abnormality of the left ventricular outflow tract (HP:0011103)2.84227783
24Subaortic stenosis (HP:0001682)2.84227783
25Abnormality of the calf musculature (HP:0001430)2.82682146
26Increased connective tissue (HP:0009025)2.76024313
27Ventricular arrhythmia (HP:0004308)2.66420530
28Double outlet right ventricle (HP:0001719)2.65494426
29Congenital malformation of the right heart (HP:0011723)2.65494426
30Prolonged QT interval (HP:0001657)2.63029740
31Fibular aplasia (HP:0002990)2.62710849
32Oligodactyly (HP:0012165)2.60573563
33Vitreoretinal degeneration (HP:0000655)2.60369302
34Difficulty climbing stairs (HP:0003551)2.59541448
35Calf muscle hypertrophy (HP:0008981)2.58984535
36Broad ribs (HP:0000885)2.57957977
37Abnormality of the lower motor neuron (HP:0002366)2.57161463
38Hyperacusis (HP:0010780)2.50240280
39Lipoatrophy (HP:0100578)2.49888864
40Exercise-induced myalgia (HP:0003738)2.48533650
41Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.47893142
42Synostosis involving the elbow (HP:0003938)2.47514640
43Humeroradial synostosis (HP:0003041)2.47514640
44Adactyly (HP:0009776)2.47163480
45Asymmetric septal hypertrophy (HP:0001670)2.45221076
46EMG: myopathic abnormalities (HP:0003458)2.37790957
47Aortic aneurysm (HP:0004942)2.37301392
48Broad metatarsal (HP:0001783)2.37135257
49Hypoplastic ischia (HP:0003175)2.36360732
50Lymphangioma (HP:0100764)2.34838678
51Cutaneous finger syndactyly (HP:0010554)2.33410950
52Hepatoblastoma (HP:0002884)2.32471405
53Arterial tortuosity (HP:0005116)2.29874559
54Aneurysm (HP:0002617)2.27778969
55Limited hip movement (HP:0008800)2.27481791
56Action tremor (HP:0002345)2.24492051
57Urethral obstruction (HP:0000796)2.23825068
58Preaxial foot polydactyly (HP:0001841)2.23596436
59Septo-optic dysplasia (HP:0100842)2.22859946
60Scapular winging (HP:0003691)2.22301731
61Muscle hypertrophy of the lower extremities (HP:0008968)2.21529678
62Rapidly progressive (HP:0003678)2.20333555
63Dysmetric saccades (HP:0000641)2.18547725
64Mitral valve prolapse (HP:0001634)2.16015237
65Vascular tortuosity (HP:0004948)2.14991665
66Bladder diverticulum (HP:0000015)2.14757163
67Vertebral arch anomaly (HP:0008438)2.14653902
68Increased variability in muscle fiber diameter (HP:0003557)2.13222203
69Hypoplastic nipples (HP:0002557)2.13063962
70Renal duplication (HP:0000075)2.12460543
71Cutaneous syndactyly (HP:0012725)2.12275366
72Maternal diabetes (HP:0009800)2.11896042
73Neonatal short-limb short stature (HP:0008921)2.10766726
74Heart block (HP:0012722)2.10157416
75Distal upper limb amyotrophy (HP:0007149)2.08782563
76Upper limb amyotrophy (HP:0009129)2.08782563
77Hemiplegia (HP:0002301)2.08350442
78Ulnar deviation of finger (HP:0009465)2.05954942
79Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.03567554
80Elfin facies (HP:0004428)2.03526314
81Partial duplication of thumb phalanx (HP:0009944)2.02519576
82Abnormal atrioventricular conduction (HP:0005150)2.01905790
83Abnormal EKG (HP:0003115)2.01306399
84Vertebral clefting (HP:0008428)2.01241339
85Atrioventricular block (HP:0001678)2.00065171
86Aplasia involving bones of the upper limbs (HP:0009823)1.99775007
87Aplasia of the phalanges of the hand (HP:0009802)1.99775007
88Aplasia involving bones of the extremities (HP:0009825)1.99775007
89Lower limb amyotrophy (HP:0007210)1.98150578
90Abnormality of the ischium (HP:0003174)1.98084432
91Myokymia (HP:0002411)1.97634086
92Hematochezia (HP:0002573)1.96745683
93Papillary thyroid carcinoma (HP:0002895)1.94974428
94Protrusio acetabuli (HP:0003179)1.92542342
95Midline defect of the nose (HP:0004122)1.91661214
96Hypoplasia of the iris (HP:0007676)1.91615372
97Macroorchidism (HP:0000053)1.91149175
98EMG: neuropathic changes (HP:0003445)1.90811259
99Insomnia (HP:0100785)1.90449007
100Striae distensae (HP:0001065)1.90321368
101Mildly elevated creatine phosphokinase (HP:0008180)1.89078472
102Myelomeningocele (HP:0002475)1.85619069
103Bicornuate uterus (HP:0000813)1.85010621
104Myotonia (HP:0002486)1.84375102
105Pointed chin (HP:0000307)1.82566945
106Morphological abnormality of the middle ear (HP:0008609)1.81178635
107Termporal pattern (HP:0011008)1.79588865
108Insidious onset (HP:0003587)1.79588865
109Partial duplication of the phalanx of hand (HP:0009999)1.78941272
110Drooling (HP:0002307)1.78412315
111Wide anterior fontanel (HP:0000260)1.78367094
112Hand muscle atrophy (HP:0009130)1.78079317
113Periauricular skin pits (HP:0100277)1.77985612
114Preauricular pit (HP:0004467)1.77985612
115Dilated cardiomyopathy (HP:0001644)1.77285188
116Abnormality of the foot musculature (HP:0001436)1.77131092
117Neurofibrillary tangles (HP:0002185)1.77073101
118Left ventricular hypertrophy (HP:0001712)1.76676068
119Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76483879
120Short 4th metacarpal (HP:0010044)1.76483879
121Abnormality of the 4th metacarpal (HP:0010012)1.76141508
122Patent foramen ovale (HP:0001655)1.75099742
123Ankle contracture (HP:0006466)1.74814540
124Abnormal ventriculo-arterial connection (HP:0011563)1.74682371
125Transposition of the great arteries (HP:0001669)1.74682371
126Abnormal connection of the cardiac segments (HP:0011545)1.74682371
127Distal lower limb amyotrophy (HP:0008944)1.74311859
128Abnormality of the astrocytes (HP:0100707)1.74311570
129Astrocytoma (HP:0009592)1.74311570
130Arnold-Chiari malformation (HP:0002308)1.73880560
131Cortical dysplasia (HP:0002539)1.73149312
132Abnormality of skeletal muscle fiber size (HP:0012084)1.70387201
133Meningocele (HP:0002435)1.70384369
134Skin pits (HP:0100276)1.69886121
135Barrel-shaped chest (HP:0001552)1.69529871
136Aortic dissection (HP:0002647)1.69185186
137Hamartoma of the eye (HP:0010568)1.68886177
138Symphalangism affecting the phalanges of the hand (HP:0009773)1.68556767
139Foot dorsiflexor weakness (HP:0009027)1.67435900
140Renovascular hypertension (HP:0100817)1.66695323
141Enlarged penis (HP:0000040)1.66654479
142Hemivertebrae (HP:0002937)1.66567394
143Megalencephaly (HP:0001355)1.66124713
144Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.66058170
145Bowel diverticulosis (HP:0005222)1.66056450
146Overriding aorta (HP:0002623)1.65751741
147Subacute progressive viral hepatitis (HP:0006572)1.64877467
148Abnormality of the aortic arch (HP:0012303)1.64608294
149Hip contracture (HP:0003273)1.63593170
150Focal seizures (HP:0007359)1.63495837
151Overgrowth (HP:0001548)1.62634230
152Genetic anticipation (HP:0003743)1.62439998
153Flat cornea (HP:0007720)1.61886698
154Absent eyebrow (HP:0002223)1.61639319
155Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.61062210
156Dilatation of the ascending aorta (HP:0005111)1.60020968
157Exotropia (HP:0000577)1.59272906
158Aplasia/Hypoplasia of the fibula (HP:0006492)1.58918808
159High anterior hairline (HP:0009890)1.58912064
160Excessive salivation (HP:0003781)1.58719947
161Disproportionate tall stature (HP:0001519)1.58408997
162Postural instability (HP:0002172)1.58061831
163Achilles tendon contracture (HP:0001771)1.57257559
164Sudden cardiac death (HP:0001645)1.56268610
165Skull defect (HP:0001362)1.55166479
166Heterotopia (HP:0002282)1.55069490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK5.27699044
2TRIB33.14676558
3PKN22.95136498
4CASK2.90395392
5TTN2.86090297
6RIPK12.55746204
7TGFBR22.51739587
8MAP3K92.36232829
9LMTK22.35050295
10PDGFRA2.26719150
11ICK2.21608306
12PHKG21.98906779
13PHKG11.98906779
14DMPK1.97444702
15PRKD31.92000269
16TIE11.90765202
17EPHA31.81733091
18CAMK1G1.80425549
19TYRO31.80042739
20PAK61.73971328
21STK38L1.68122185
22LATS21.65663859
23CAMK1D1.51694164
24LATS11.46096982
25MAP3K41.41153162
26MARK11.38370427
27NEK11.35788898
28PAK41.34673782
29PINK11.32931640
30KSR21.32317458
31STK381.30196088
32MAPK151.29410129
33CDK121.27463646
34EPHB21.25545832
35PTK61.21168307
36PTK2B1.20640557
37BCR1.20324177
38EEF2K1.19687738
39MAP3K101.19205041
40SIK21.18249423
41FER1.18217305
42PIK3CA1.18188062
43PDK31.18115698
44PDK41.18115698
45CDC42BPA1.16329012
46NTRK31.12254082
47NTRK21.11588432
48DDR21.11391962
49SGK21.09201574
50RET1.08380650
51PDK21.07356243
52ALK1.07336964
53KSR11.07045637
54PAK31.06430636
55PAK21.05870726
56NEK91.01333398
57PDGFRB1.00292580
58PRKD10.99787738
59BMPR1B0.99583553
60SGK4940.99514065
61SGK2230.99514065
62AKT30.99266729
63MYLK0.98914766
64BRD40.98134800
65YES10.95605083
66ROCK10.94089331
67MTOR0.92223394
68DYRK20.90663290
69PNCK0.90653991
70CAMKK10.90250502
71CAMK40.88256199
72PLK40.86271051
73STK110.83988021
74GRK70.83223998
75WNK10.81191871
76NTRK10.80851065
77ACVR1B0.79634409
78ILK0.71964495
79STK390.71171031
80PRKCH0.71037752
81PTK20.70786845
82DYRK1B0.67993456
83MAPK120.67685192
84TAOK10.67029961
85BMX0.66805632
86OBSCN0.65916883
87EPHB10.65705170
88NLK0.64739671
89ROCK20.61062479
90SGK30.60965484
91MINK10.60665415
92SCYL20.60171309
93MAP3K70.58516443
94DYRK1A0.58083271
95PRKAA10.57950957
96STK240.56265506
97CAMK2A0.56165038
98UHMK10.55523160
99PKN10.54905610
100MAP2K70.54747950
101MAP2K40.53834424
102MET0.53829079
103MARK20.52815823
104MOS0.52230542
105PRKCZ0.51958559
106WNK30.51746455
107PRKCG0.51341324
108CSNK1G20.50946021
109PRKCE0.50716510
110PLK20.50584805
111KDR0.50307556
112CDK50.47658151
113STK30.47652563
114CAMK10.46998813
115ERBB30.45859114
116FLT30.45053903
117PDPK10.44703644
118DAPK20.44243910
119ERBB40.44185468
120TGFBR10.43332575
121CAMK2B0.43309789
122RPS6KA20.41419529
123FGR0.41188207
124MKNK20.41142960
125PRKAA20.40092493
126FGFR10.38105500
127ERBB20.37540554
128PDK10.37186743
129GSK3A0.37181831
130SRC0.36648789
131AKT20.36625233
132DAPK30.36467236
133RPS6KA30.36376564
134FGFR20.35672164
135CAMK2D0.35458635
136EPHA40.34901421
137MAPK100.34425925
138SGK10.33885487
139MAP3K60.33048974

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054142.55857053
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.21574441
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.05443370
4Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83746097
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55637444
6Focal adhesion_Homo sapiens_hsa045101.51394526
7Cardiac muscle contraction_Homo sapiens_hsa042601.51071654
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47644017
9Adherens junction_Homo sapiens_hsa045201.46854770
10Dorso-ventral axis formation_Homo sapiens_hsa043201.46382929
11Estrogen signaling pathway_Homo sapiens_hsa049151.39015451
12Type II diabetes mellitus_Homo sapiens_hsa049301.31331008
13cGMP-PKG signaling pathway_Homo sapiens_hsa040221.29944203
14Axon guidance_Homo sapiens_hsa043601.29051977
15Circadian entrainment_Homo sapiens_hsa047131.28552657
16Thyroid hormone signaling pathway_Homo sapiens_hsa049191.27212949
17Oxytocin signaling pathway_Homo sapiens_hsa049211.26990502
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26884476
19Glioma_Homo sapiens_hsa052141.25134229
20ECM-receptor interaction_Homo sapiens_hsa045121.24966604
21Renal cell carcinoma_Homo sapiens_hsa052111.24527449
22mTOR signaling pathway_Homo sapiens_hsa041501.23673505
23Olfactory transduction_Homo sapiens_hsa047401.22938643
24GnRH signaling pathway_Homo sapiens_hsa049121.21296315
25Long-term potentiation_Homo sapiens_hsa047201.20462405
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.20329935
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19256416
28Gastric acid secretion_Homo sapiens_hsa049711.18803519
29Proteoglycans in cancer_Homo sapiens_hsa052051.18122265
30Viral myocarditis_Homo sapiens_hsa054161.17942195
31Tight junction_Homo sapiens_hsa045301.16892606
32Renin secretion_Homo sapiens_hsa049241.16573815
33Protein digestion and absorption_Homo sapiens_hsa049741.15792132
34Gap junction_Homo sapiens_hsa045401.13501881
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11843183
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09564441
37Notch signaling pathway_Homo sapiens_hsa043301.09407118
38Glutamatergic synapse_Homo sapiens_hsa047241.08413815
39Hippo signaling pathway_Homo sapiens_hsa043901.08359495
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06682736
41Phospholipase D signaling pathway_Homo sapiens_hsa040721.05914153
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05126127
43Salivary secretion_Homo sapiens_hsa049701.04069833
44cAMP signaling pathway_Homo sapiens_hsa040241.04023144
45Colorectal cancer_Homo sapiens_hsa052100.99484892
46Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98837012
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98782750
48Cholinergic synapse_Homo sapiens_hsa047250.98237875
49Chronic myeloid leukemia_Homo sapiens_hsa052200.97626375
50VEGF signaling pathway_Homo sapiens_hsa043700.97287720
51Circadian rhythm_Homo sapiens_hsa047100.97148699
52* Rap1 signaling pathway_Homo sapiens_hsa040150.97063937
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96737569
54Endometrial cancer_Homo sapiens_hsa052130.96154841
55Thyroid hormone synthesis_Homo sapiens_hsa049180.95873671
56Synaptic vesicle cycle_Homo sapiens_hsa047210.95794910
57Calcium signaling pathway_Homo sapiens_hsa040200.94569116
58Insulin secretion_Homo sapiens_hsa049110.94294363
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94113237
60MicroRNAs in cancer_Homo sapiens_hsa052060.93977539
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.91702799
62Melanogenesis_Homo sapiens_hsa049160.91313316
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91046629
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91036350
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.90963230
66GABAergic synapse_Homo sapiens_hsa047270.90746490
67Dopaminergic synapse_Homo sapiens_hsa047280.90137807
68ErbB signaling pathway_Homo sapiens_hsa040120.90053705
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89395736
70Amoebiasis_Homo sapiens_hsa051460.89355366
71Ovarian steroidogenesis_Homo sapiens_hsa049130.88886897
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88440149
73Glucagon signaling pathway_Homo sapiens_hsa049220.86827442
74Insulin signaling pathway_Homo sapiens_hsa049100.86662827
75Bile secretion_Homo sapiens_hsa049760.86225389
76HIF-1 signaling pathway_Homo sapiens_hsa040660.86148752
77Morphine addiction_Homo sapiens_hsa050320.85870451
78Pathways in cancer_Homo sapiens_hsa052000.85390206
79Insulin resistance_Homo sapiens_hsa049310.84842779
80Amphetamine addiction_Homo sapiens_hsa050310.84803735
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.84176085
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83567109
83Nicotine addiction_Homo sapiens_hsa050330.83141086
84MAPK signaling pathway_Homo sapiens_hsa040100.83033692
85Long-term depression_Homo sapiens_hsa047300.83005484
86Endocytosis_Homo sapiens_hsa041440.79497965
87Basal cell carcinoma_Homo sapiens_hsa052170.79240836
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.79181886
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77046030
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76039708
91Taste transduction_Homo sapiens_hsa047420.75764177
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75727222
93Small cell lung cancer_Homo sapiens_hsa052220.74020520
94Choline metabolism in cancer_Homo sapiens_hsa052310.72446340
95Pancreatic secretion_Homo sapiens_hsa049720.72324545
96Wnt signaling pathway_Homo sapiens_hsa043100.72226507
97Pancreatic cancer_Homo sapiens_hsa052120.71282702
98Hedgehog signaling pathway_Homo sapiens_hsa043400.70926923
99Inositol phosphate metabolism_Homo sapiens_hsa005620.69905968
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69726476
101Lysine degradation_Homo sapiens_hsa003100.69558484
102AMPK signaling pathway_Homo sapiens_hsa041520.69486224
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69269490
104TGF-beta signaling pathway_Homo sapiens_hsa043500.69187099
105Oocyte meiosis_Homo sapiens_hsa041140.67760223
106Platelet activation_Homo sapiens_hsa046110.67399001
107Nitrogen metabolism_Homo sapiens_hsa009100.66898122
108Ras signaling pathway_Homo sapiens_hsa040140.66713086
109FoxO signaling pathway_Homo sapiens_hsa040680.66606999
110Cocaine addiction_Homo sapiens_hsa050300.63004933
111Melanoma_Homo sapiens_hsa052180.62919666
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.62721483
113Non-small cell lung cancer_Homo sapiens_hsa052230.62102913
114Prion diseases_Homo sapiens_hsa050200.62069140
115Serotonergic synapse_Homo sapiens_hsa047260.61067061
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59598557
117Prolactin signaling pathway_Homo sapiens_hsa049170.57186004
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56176368
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.55259685
120Prostate cancer_Homo sapiens_hsa052150.55203474
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51136010

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