SIRPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.70102550
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.70102550
3modulation by symbiont of host immune response (GO:0052553)6.70102550
4positive regulation by symbiont of host defense response (GO:0052509)6.70102550
5modulation by symbiont of host defense response (GO:0052031)6.70102550
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.70102550
7regulation of interferon-beta biosynthetic process (GO:0045357)5.54811648
8macrophage activation involved in immune response (GO:0002281)5.41041002
9microglial cell activation (GO:0001774)5.19196788
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.45814392
11response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.40914136
12response to host immune response (GO:0052572)4.40914136
13positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.25517946
14negative regulation of interleukin-12 production (GO:0032695)4.19012580
15response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.06450419
16response to host (GO:0075136)4.06450419
17response to host defenses (GO:0052200)4.06450419
18neutrophil activation involved in immune response (GO:0002283)3.94158406
19macrophage activation (GO:0042116)3.81900444
20negative regulation of cell killing (GO:0031342)3.77934622
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.77934622
22positive regulation of interferon-alpha production (GO:0032727)3.70595271
23regulation of B cell receptor signaling pathway (GO:0050855)3.67435189
24detection of molecule of bacterial origin (GO:0032490)3.67053233
25positive regulation of cellular amide metabolic process (GO:0034250)3.61778564
26regulation of interferon-alpha production (GO:0032647)3.49985082
27myeloid cell activation involved in immune response (GO:0002275)3.48580643
28response to peptidoglycan (GO:0032494)3.47526623
29detection of other organism (GO:0098543)3.43793632
30regulation of T-helper 2 cell differentiation (GO:0045628)3.30456834
31L-amino acid import (GO:0043092)3.29478656
32I-kappaB phosphorylation (GO:0007252)3.27372188
33detection of external biotic stimulus (GO:0098581)3.24380361
34negative regulation of erythrocyte differentiation (GO:0045647)3.21218543
35synaptic vesicle maturation (GO:0016188)3.20143399
36detection of bacterium (GO:0016045)3.13831496
37respiratory burst (GO:0045730)3.10634990
38neutrophil mediated immunity (GO:0002446)3.10307949
39immunoglobulin mediated immune response (GO:0016064)3.09244484
40negative regulation of interleukin-17 production (GO:0032700)3.04069180
41protein localization to endosome (GO:0036010)3.02840704
42positive regulation of mast cell activation (GO:0033005)2.99681087
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92881391
44germinal center formation (GO:0002467)2.92789959
45regulation of mast cell degranulation (GO:0043304)2.90138796
46apoptotic cell clearance (GO:0043277)2.89880720
47regulation of leukocyte degranulation (GO:0043300)2.89258128
48detection of biotic stimulus (GO:0009595)2.86321165
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.85690233
50phagosome maturation (GO:0090382)2.83767884
51mannose metabolic process (GO:0006013)2.81912796
52granulocyte activation (GO:0036230)2.81718562
53positive regulation of antigen processing and presentation (GO:0002579)2.81265869
54antigen processing and presentation of endogenous antigen (GO:0019883)2.80673910
55regulation of mast cell activation involved in immune response (GO:0033006)2.77792412
56locomotory exploration behavior (GO:0035641)2.77508393
57regulation of macrophage cytokine production (GO:0010935)2.77485238
58positive regulation of mast cell activation involved in immune response (GO:0033008)2.76130156
59positive regulation of mast cell degranulation (GO:0043306)2.76130156
60regulation of regulated secretory pathway (GO:1903305)2.75794735
61lipopolysaccharide-mediated signaling pathway (GO:0031663)2.75621084
62neutrophil activation (GO:0042119)2.74896472
63regulation of interleukin-8 biosynthetic process (GO:0045414)2.73344079
64regulation of beta-amyloid formation (GO:1902003)2.72283796
65interferon-gamma-mediated signaling pathway (GO:0060333)2.70370918
66amino acid import (GO:0043090)2.69826354
67cellular potassium ion homeostasis (GO:0030007)2.69104078
68regulation of ARF protein signal transduction (GO:0032012)2.68906936
69T-helper 1 type immune response (GO:0042088)2.68075888
70response to muramyl dipeptide (GO:0032495)2.67609542
71leukocyte aggregation (GO:0070486)2.66844443
72positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66527924
73regulation of cellular amide metabolic process (GO:0034248)2.63663882
74positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.63386507
75regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.63197971
76regulation of myeloid leukocyte mediated immunity (GO:0002886)2.61905195
77positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.61706814
78positive regulation of leukocyte degranulation (GO:0043302)2.60674474
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.60502444
80positive regulation of type 2 immune response (GO:0002830)2.60001017
81negative regulation of cytokine production involved in immune response (GO:0002719)2.59470946
82regulation of mast cell activation (GO:0033003)2.58711834
83regulation of gamma-delta T cell activation (GO:0046643)2.57881398
84regulation of type 2 immune response (GO:0002828)2.57498969
85sodium ion export (GO:0071436)2.57094126
86negative regulation of leukocyte mediated immunity (GO:0002704)2.55758925
87synaptic vesicle docking involved in exocytosis (GO:0016081)2.54735456
88positive regulation of macrophage cytokine production (GO:0060907)2.53945272
89positive regulation of regulated secretory pathway (GO:1903307)2.53062091
90regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52994869
91regulation of macrophage chemotaxis (GO:0010758)2.52803440
92alanine transport (GO:0032328)2.52503919
93amino sugar catabolic process (GO:0046348)2.52419415
94regulation of short-term neuronal synaptic plasticity (GO:0048172)2.51335755
95negative regulation of type 2 immune response (GO:0002829)2.50406068
96negative regulation of toll-like receptor signaling pathway (GO:0034122)2.50256233
97barbed-end actin filament capping (GO:0051016)2.49758601
98myeloid leukocyte mediated immunity (GO:0002444)2.49522994
99negative regulation of interleukin-6 production (GO:0032715)2.47817644
100negative regulation of lymphocyte mediated immunity (GO:0002707)2.47740183
101regulation of synapse structural plasticity (GO:0051823)2.46036727
102regulation of dendritic cell antigen processing and presentation (GO:0002604)2.44528910
103neutrophil chemotaxis (GO:0030593)2.44407572
104synaptic vesicle exocytosis (GO:0016079)2.43478789
105proline transport (GO:0015824)2.42651316
106adenosine receptor signaling pathway (GO:0001973)2.42067232
107glycolipid catabolic process (GO:0019377)2.41229553
108myeloid dendritic cell differentiation (GO:0043011)2.40507725
109negative regulation of granulocyte differentiation (GO:0030853)2.39690974
110positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.39562180
111regulation of vitamin D biosynthetic process (GO:0060556)2.39227050
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.38706142
113signal complex assembly (GO:0007172)2.38641021
114positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.38547982
115regulation of clathrin-mediated endocytosis (GO:2000369)2.37837747
116regulation of amyloid precursor protein catabolic process (GO:1902991)2.37546540
117myeloid leukocyte activation (GO:0002274)2.37353667
118neutrophil migration (GO:1990266)2.37347978
119positive regulation of interferon-beta production (GO:0032728)2.37074412
120lipoprotein transport (GO:0042953)2.36531129
121positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.36439481
122positive regulation of gamma-delta T cell activation (GO:0046645)2.36368420
123regulation of synaptic vesicle exocytosis (GO:2000300)2.36013481
124positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.35950817
125clathrin coat assembly (GO:0048268)2.35362926
126positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.33053489
127regulation of ARF GTPase activity (GO:0032312)2.32616232
128cellular extravasation (GO:0045123)2.32027065
129glycosphingolipid catabolic process (GO:0046479)2.30649134
130pinocytosis (GO:0006907)2.29472989
131positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.28966997
132phagocytosis (GO:0006909)2.28209087
133regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.26348078
134G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.26155036
135synaptic vesicle endocytosis (GO:0048488)2.22353739
136regulation of cholesterol storage (GO:0010885)2.22294109
137regulation of mononuclear cell migration (GO:0071675)2.21205805
138cellular response to thyroid hormone stimulus (GO:0097067)2.20814945
139hydrogen peroxide biosynthetic process (GO:0050665)2.20785480
140regulation of glutamate receptor signaling pathway (GO:1900449)2.20322122
141positive regulation of phagocytosis (GO:0050766)2.19543914

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.67974500
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.99766449
3* IRF8_27001747_Chip-Seq_BMDM_Mouse3.60060660
4* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.50097497
5Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.32680825
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.27905470
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80620142
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.39840199
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.34342774
10IKZF1_21737484_ChIP-ChIP_HCT116_Human2.25887987
11SPI1_23127762_ChIP-Seq_K562_Human2.25361430
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.24322465
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19463722
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17051675
15* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93806279
16DROSHA_22980978_ChIP-Seq_HELA_Human1.89199957
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86077270
18SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80122590
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.77198766
20PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.67673356
21* VDR_24787735_ChIP-Seq_THP-1_Human1.66076852
22NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.63485662
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61651426
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60466085
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57717132
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.54690251
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.54400414
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52138175
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51520975
30GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51418424
31SCL_19346495_ChIP-Seq_HPC-7_Human1.47774720
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47098908
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46305161
34RUNX_20019798_ChIP-Seq_JUKART_Human1.45072375
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42462689
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42038667
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.41351233
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.41169906
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.40886999
40EZH2_22144423_ChIP-Seq_EOC_Human1.38078087
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.36266270
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34203491
43* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31653006
44* VDR_24763502_ChIP-Seq_THP-1_Human1.31633118
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31458414
46SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.31101093
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29298904
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28968320
49PU_27001747_Chip-Seq_BMDM_Mouse1.27991452
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26675852
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25510396
52MAF_26560356_Chip-Seq_TH1_Human1.24255229
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23636391
54* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.22406492
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20683661
56REST_21632747_ChIP-Seq_MESCs_Mouse1.19932580
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19834632
58KDM2B_26808549_Chip-Seq_K562_Human1.19750482
59GBX2_23144817_ChIP-Seq_PC3_Human1.18489465
60* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17769118
61KDM2B_26808549_Chip-Seq_DND41_Human1.17235559
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16758063
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14004833
64LXR_22292898_ChIP-Seq_THP-1_Human1.12169578
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12051533
66GATA1_19941826_ChIP-Seq_K562_Human1.11316368
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10460968
68TCF7_22412390_ChIP-Seq_EML_Mouse1.09012754
69GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08484306
70RXR_22108803_ChIP-Seq_LS180_Human1.08435967
71TP53_16413492_ChIP-PET_HCT116_Human1.08295233
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06732628
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06414951
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05894880
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.04925726
76* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03595129
77* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03595129
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03591179
79VDR_21846776_ChIP-Seq_THP-1_Human1.03347370
80RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03338311
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.03076077
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02591574
83RACK7_27058665_Chip-Seq_MCF-7_Human1.02346270
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.02270952
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01928535
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.01784475
87UTX_26944678_Chip-Seq_JUKART_Human1.01680954
88SPI1_23547873_ChIP-Seq_NB4_Human1.01037411
89* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99406879
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99044548
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98997932
92WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98843117
93JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96671571
94EGR1_19032775_ChIP-ChIP_M12_Human0.96579996
95CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96366043
96GATA2_19941826_ChIP-Seq_K562_Human0.96068406
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95278494
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95065306
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94959440
100GATA1_22025678_ChIP-Seq_K562_Human0.94739498
101NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94668453
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93368007
103MYC_22102868_ChIP-Seq_BL_Human0.92861775
104AHR_22903824_ChIP-Seq_MCF-7_Human0.91350947
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91172462
106MAF_26560356_Chip-Seq_TH2_Human0.91087913
107SMC4_20622854_ChIP-Seq_HELA_Human0.89262491
108REST_18959480_ChIP-ChIP_MESCs_Mouse0.88232274
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87989607
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87989607
111RNF2_27304074_Chip-Seq_ESCs_Mouse0.86554403
112SA1_27219007_Chip-Seq_ERYTHROID_Human0.86465783
113ERG_21242973_ChIP-ChIP_JURKAT_Human0.86200644
114SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85991006
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85977873
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85888185
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85845161
118MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85092759
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85015004
120JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84802987
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.84776071
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84653865
123CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84439541
124CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84166096
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.83974102
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81182802
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79130503
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79125006
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78913576
130GATA3_27048872_Chip-Seq_THYMUS_Human0.78879549

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.98981325
2MP0003172_abnormal_lysosome_physiology4.40320554
3MP0000569_abnormal_digit_pigmentation4.07720972
4MP0003303_peritoneal_inflammation3.73483324
5MP0004859_abnormal_synaptic_plasticity3.53874273
6MP0003690_abnormal_glial_cell2.84707760
7MP0006082_CNS_inflammation2.80688492
8MP0004510_myositis2.76967165
9MP0001835_abnormal_antigen_presentation2.76730375
10MP0003183_abnormal_peptide_metabolism2.67834863
11MP0003436_decreased_susceptibility_to2.51226779
12* MP0002419_abnormal_innate_immunity2.50716719
13MP0003075_altered_response_to2.46102144
14MP0000604_amyloidosis2.43903257
15MP0003191_abnormal_cellular_cholesterol2.34722183
16MP0009840_abnormal_foam_cell2.14225671
17MP0005167_abnormal_blood-brain_barrier2.10782003
18MP0003300_gastrointestinal_ulcer2.03224619
19MP0005464_abnormal_platelet_physiology1.99298831
20MP0005000_abnormal_immune_tolerance1.96406003
21MP0004858_abnormal_nervous_system1.86152484
22MP0008260_abnormal_autophagy1.84416883
23MP0002148_abnormal_hypersensitivity_rea1.78647324
24MP0002064_seizures1.76321221
25MP0003635_abnormal_synaptic_transmissio1.74420649
26MP0009046_muscle_twitch1.72413699
27* MP0002452_abnormal_antigen_presenting1.68939560
28MP0001790_abnormal_immune_system1.60767620
29MP0005387_immune_system_phenotype1.60767620
30MP0005025_abnormal_response_to1.59726687
31MP0009278_abnormal_bone_marrow1.59515869
32MP0001533_abnormal_skeleton_physiology1.54820419
33MP0002090_abnormal_vision1.53419362
34MP0005310_abnormal_salivary_gland1.52069726
35MP0002723_abnormal_immune_serum1.51428323
36MP0005166_decreased_susceptibility_to1.50621183
37MP0003828_pulmonary_edema1.49871012
38MP0005451_abnormal_body_composition1.49849113
39MP0005174_abnormal_tail_pigmentation1.49146891
40MP0003633_abnormal_nervous_system1.44173789
41MP0001800_abnormal_humoral_immune1.39203597
42MP0009785_altered_susceptibility_to1.37809384
43* MP0001819_abnormal_immune_cell1.34380079
44MP0002998_abnormal_bone_remodeling1.32576555
45* MP0002420_abnormal_adaptive_immunity1.31992562
46MP0003634_abnormal_glial_cell1.30824746
47MP0001501_abnormal_sleep_pattern1.30149997
48MP0002063_abnormal_learning/memory/cond1.29873794
49MP0009745_abnormal_behavioral_response1.29435586
50MP0000343_altered_response_to1.29084066
51MP0005257_abnormal_intraocular_pressure1.28753922
52MP0005671_abnormal_response_to1.27479316
53MP0003329_amyloid_beta_deposits1.25768200
54MP0000858_altered_metastatic_potential1.21753522
55MP0000015_abnormal_ear_pigmentation1.19849154
56MP0003279_aneurysm1.19729519
57MP0000920_abnormal_myelination1.18781586
58MP0010155_abnormal_intestine_physiology1.18304470
59MP0002909_abnormal_adrenal_gland1.18001577
60MP0001851_eye_inflammation1.16548390
61MP0008004_abnormal_stomach_pH1.15579464
62MP0004947_skin_inflammation1.14778332
63MP0003453_abnormal_keratinocyte_physiol1.12924086
64MP0002572_abnormal_emotion/affect_behav1.11839898
65MP0000685_abnormal_immune_system1.10330969
66MP0001845_abnormal_inflammatory_respons1.10233047
67MP0003448_altered_tumor_morphology1.09502604
68MP0004270_analgesia1.06091577
69MP0008469_abnormal_protein_level1.03279695
70MP0001958_emphysema1.01434147
71MP0002405_respiratory_system_inflammati1.01191746
72MP0003880_abnormal_central_pattern1.00675479
73MP0003631_nervous_system_phenotype0.97532812
74MP0003724_increased_susceptibility_to0.97038039
75MP0004130_abnormal_muscle_cell0.96880971
76MP0008569_lethality_at_weaning0.96575068
77MP0001968_abnormal_touch/_nociception0.96306972
78MP0002254_reproductive_system_inflammat0.95780770
79MP0010386_abnormal_urinary_bladder0.94637418
80MP0005390_skeleton_phenotype0.93102282
81MP0003566_abnormal_cell_adhesion0.93009760
82MP0010307_abnormal_tumor_latency0.92402539
83MP0003045_fibrosis0.92109854
84MP0001440_abnormal_grooming_behavior0.90257915
85MP0002736_abnormal_nociception_after0.89099940
86MP0009780_abnormal_chondrocyte_physiolo0.88976831
87MP0001849_ear_inflammation0.88322682
88MP0002877_abnormal_melanocyte_morpholog0.85981301
89MP0001486_abnormal_startle_reflex0.84493595
90MP0000371_diluted_coat_color0.83045228
91MP0001853_heart_inflammation0.82523797
92MP0000465_gastrointestinal_hemorrhage0.80614810
93MP0009333_abnormal_splenocyte_physiolog0.80039491
94* MP0002398_abnormal_bone_marrow0.79975427
95* MP0000716_abnormal_immune_system0.79622398
96MP0009764_decreased_sensitivity_to0.79485145
97MP0001970_abnormal_pain_threshold0.79383779
98MP0002139_abnormal_hepatobiliary_system0.79305150
99MP0003879_abnormal_hair_cell0.78365978
100MP0003091_abnormal_cell_migration0.75753380
101MP0002733_abnormal_thermal_nociception0.75683999
102MP0004811_abnormal_neuron_physiology0.75517592
103MP0008961_abnormal_basal_metabolism0.75390955
104MP0005023_abnormal_wound_healing0.74535069
105MP0005165_increased_susceptibility_to0.74179367
106MP0005164_abnormal_response_to0.73530511
107MP0005076_abnormal_cell_differentiation0.73014252
108MP0008874_decreased_physiological_sensi0.72861135
109MP0003656_abnormal_erythrocyte_physiolo0.72562209
110MP0005388_respiratory_system_phenotype0.72233208
111MP0002133_abnormal_respiratory_system0.72233208
112MP0002067_abnormal_sensory_capabilities0.72059468
113MP0002332_abnormal_exercise_endurance0.71846065
114MP0003632_abnormal_nervous_system0.71779975
115MP0006054_spinal_hemorrhage0.71767827
116MP0000689_abnormal_spleen_morphology0.71616046
117MP0005397_hematopoietic_system_phenotyp0.70676441
118MP0001545_abnormal_hematopoietic_system0.70676441
119MP0004883_abnormal_blood_vessel0.70237679
120* MP0002429_abnormal_blood_cell0.70159771
121MP0003795_abnormal_bone_structure0.69906396
122MP0005409_darkened_coat_color0.68587134
123MP0005535_abnormal_body_temperature0.67703244
124MP0000249_abnormal_blood_vessel0.67594436
125MP0003705_abnormal_hypodermis_morpholog0.66650212

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)6.44806692
2Recurrent abscess formation (HP:0002722)5.53353842
3Abnormality of liposaccharide metabolism (HP:0010968)5.37877536
4Abnormality of glycosphingolipid metabolism (HP:0004343)5.37877536
5Abnormality of glycolipid metabolism (HP:0010969)5.37877536
6Increased neuronal autofluorescent lipopigment (HP:0002074)5.33354276
7Recurrent bacterial skin infections (HP:0005406)5.04471138
8Dysostosis multiplex (HP:0000943)4.93837217
9Systemic lupus erythematosus (HP:0002725)4.85349197
10Eczematoid dermatitis (HP:0000976)4.49892919
11Vacuolated lymphocytes (HP:0001922)4.46240743
12Recurrent gram-negative bacterial infections (HP:0005420)4.12073284
13Urinary glycosaminoglycan excretion (HP:0003541)4.00543350
14Mucopolysacchariduria (HP:0008155)4.00543350
15Disinhibition (HP:0000734)3.96482675
16Abnormality of polysaccharide metabolism (HP:0011012)3.92797050
17Abnormality of glycosaminoglycan metabolism (HP:0004371)3.92797050
18Abnormality of mucopolysaccharide metabolism (HP:0011020)3.92797050
19Abnormality of macrophages (HP:0004311)3.90383996
20Glomerulonephritis (HP:0000099)3.78628156
21Mutism (HP:0002300)3.76994062
22Axonal loss (HP:0003447)3.63036360
23Neuronal loss in central nervous system (HP:0002529)3.47073630
24Supranuclear gaze palsy (HP:0000605)3.40672401
25Loss of speech (HP:0002371)3.26724043
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.11930282
27Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07384823
28Gingivitis (HP:0000230)3.00129481
29Mediastinal lymphadenopathy (HP:0100721)2.98073380
30Retinal atrophy (HP:0001105)2.96180395
31Apathy (HP:0000741)2.87491130
32Neurofibrillary tangles (HP:0002185)2.86994376
33Inappropriate behavior (HP:0000719)2.82257124
34Recurrent skin infections (HP:0001581)2.78048840
35J-shaped sella turcica (HP:0002680)2.77798980
36Diplopia (HP:0000651)2.74776929
37Abnormality of binocular vision (HP:0011514)2.74776929
38Diminished motivation (HP:0000745)2.73322195
39Global brain atrophy (HP:0002283)2.69868373
40Hematochezia (HP:0002573)2.69827347
41Spontaneous hematomas (HP:0007420)2.67250509
42Upper motor neuron abnormality (HP:0002127)2.59701774
43Agnosia (HP:0010524)2.58920464
44Obstructive lung disease (HP:0006536)2.49550327
45Chronic obstructive pulmonary disease (HP:0006510)2.49550327
46Stomatitis (HP:0010280)2.48750448
47Focal motor seizures (HP:0011153)2.47392656
48Cerebral inclusion bodies (HP:0100314)2.45436034
49Visual hallucinations (HP:0002367)2.41441359
50Amyloidosis (HP:0011034)2.41112075
51Asymmetric septal hypertrophy (HP:0001670)2.38515121
52Cerebral aneurysm (HP:0004944)2.36904063
53Arterial tortuosity (HP:0005116)2.35788599
54Purpura (HP:0000979)2.35735802
55Autoimmune thrombocytopenia (HP:0001973)2.35359619
56Keratoconjunctivitis sicca (HP:0001097)2.32478086
57Papilledema (HP:0001085)2.29180119
58Complement deficiency (HP:0004431)2.29158532
59Postural instability (HP:0002172)2.28397334
60Focal seizures (HP:0007359)2.26579843
61Nuclear cataract (HP:0100018)2.25598849
62Dementia (HP:0000726)2.23133379
63Nephritis (HP:0000123)2.22421092
64Increased CSF protein (HP:0002922)2.21768750
65Myositis (HP:0100614)2.19108572
66Pulmonary infiltrates (HP:0002113)2.16814158
67Slow saccadic eye movements (HP:0000514)2.16140332
68Elevated erythrocyte sedimentation rate (HP:0003565)2.16017806
69Gastrointestinal infarctions (HP:0005244)2.14960975
70Obstructive sleep apnea (HP:0002870)2.14544739
71Action tremor (HP:0002345)2.13911470
72Hemoptysis (HP:0002105)2.13566065
73Recurrent fungal infections (HP:0002841)2.12001821
74Clumsiness (HP:0002312)2.11720682
75Meningitis (HP:0001287)2.10439240
76Abnormality of the periventricular white matter (HP:0002518)2.09564113
77Periodontitis (HP:0000704)2.09482995
78Increased IgE level (HP:0003212)2.09139411
79Thoracic kyphosis (HP:0002942)2.07388663
80Pathologic fracture (HP:0002756)2.07141738
81Memory impairment (HP:0002354)2.06798039
82Keratoconjunctivitis (HP:0001096)2.05087601
83Progressive visual loss (HP:0000529)2.04528734
84Thick nail (HP:0001805)2.04090716
85Vasculitis (HP:0002633)2.03993050
86Myocardial infarction (HP:0001658)2.03227472
87Orchitis (HP:0100796)2.02325658
88Segmental peripheral demyelination/remyelination (HP:0003481)2.01743291
89Vascular tortuosity (HP:0004948)2.01570911
90Basal ganglia calcification (HP:0002135)2.01524492
91Abnormality of complement system (HP:0005339)2.00195168
92Peripheral demyelination (HP:0011096)1.98281829
93Episodic fever (HP:0001954)1.97850646
94Cellulitis (HP:0100658)1.97776355
95Colitis (HP:0002583)1.97539169
96Peripheral hypomyelination (HP:0007182)1.96733960
97Hepatosplenomegaly (HP:0001433)1.96661319
98Progressive neurologic deterioration (HP:0002344)1.96031814
99Interstitial pulmonary disease (HP:0006530)1.93410865
100Hemiplegia (HP:0002301)1.92395253
101Ankle clonus (HP:0011448)1.91939803
102Abnormality of the lumbar spine (HP:0100712)1.90721178
103Myokymia (HP:0002411)1.89729233
104Urethral obstruction (HP:0000796)1.88790599
105Peritonitis (HP:0002586)1.87501786
106Deformed sella turcica (HP:0002681)1.85332939
107Pulmonary embolism (HP:0002204)1.82154905
108Petechiae (HP:0000967)1.80931638
109Prostate neoplasm (HP:0100787)1.80914761
110Increased serum ferritin (HP:0003281)1.80511180
111Frequent falls (HP:0002359)1.80430741
112Vertigo (HP:0002321)1.80362961
113Vertebral compression fractures (HP:0002953)1.80085514
114Ocular albinism (HP:0001107)1.80007194
115Recurrent cutaneous fungal infections (HP:0011370)1.79412471
116Chronic mucocutaneous candidiasis (HP:0002728)1.79412471
117Neurodegeneration (HP:0002180)1.79234234
118Gingival bleeding (HP:0000225)1.78799395
119Rapidly progressive (HP:0003678)1.78131747
120Premature loss of primary teeth (HP:0006323)1.77807530
121Striae distensae (HP:0001065)1.77580015
122Personality changes (HP:0000751)1.76985314
123Bone pain (HP:0002653)1.75762530
124Polygenic inheritance (HP:0010982)1.74897211
125Absent frontal sinuses (HP:0002688)1.74004165
126Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72884501
127Generalized tonic-clonic seizures (HP:0002069)1.71983194
128Urticaria (HP:0001025)1.71683903
129Retrobulbar optic neuritis (HP:0100654)1.70996543
130Optic neuritis (HP:0100653)1.70996543
131Spondylolisthesis (HP:0003302)1.70882610
132Abnormality of the thoracic spine (HP:0100711)1.68025823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.11813343
2MAP3K92.69340098
3TGFBR22.64814055
4FES2.44045052
5DAPK22.38098656
6MAP3K132.31939990
7EPHA42.25335439
8CAMKK12.14437945
9BLK2.07412963
10TYK22.00620092
11CAMKK22.00530946
12CAMK1G1.94660715
13MAP3K111.92239474
14CAMK1D1.92104428
15KIT1.92015595
16TBK11.86934016
17SIK21.86695848
18KSR21.85228521
19NTRK31.78208204
20CSF1R1.77201468
21IRAK41.73096293
22MAP3K31.70606259
23IRAK31.63915335
24RIPK11.63335152
25FGR1.62858310
26TRIB31.62131942
27TAOK21.56656698
28JAK11.55954941
29MAP3K141.55234529
30ERN11.54436997
31DDR21.48191581
32HCK1.35915267
33PAK61.31884917
34SCYL21.28746953
35MAP4K11.24439942
36CDC42BPA1.23183400
37TAOK31.15097455
38DAPK11.14055874
39GRK71.13374367
40MARK21.13153701
41MAP3K21.10704586
42NTRK11.08696370
43SYK1.03619079
44PDK11.00220495
45MINK11.00134168
46CSK0.99468706
47PDPK10.98100744
48PRKCH0.97335140
49PRKD30.96279533
50SGK30.92896522
51IKBKE0.91209259
52IRAK20.90447938
53PKN20.90262706
54ARAF0.88737488
55MATK0.87983012
56PLK20.85801795
57PTK60.84540409
58CDK50.82181148
59NTRK20.81772366
60TYRO30.79421590
61PTK2B0.78963685
62MOS0.77692894
63FYN0.77322203
64GRK50.77289975
65STK380.75744718
66PRKD20.74896003
67MAP3K40.72952194
68LYN0.72895987
69ZAP700.72840635
70MAP3K10.71917669
71TTN0.71231475
72MAP2K30.70307426
73EGFR0.69635812
74RET0.69333743
75PAK40.68865410
76CLK10.68452150
77LATS20.67768038
78IKBKB0.67413292
79UHMK10.67144631
80EPHB10.67076274
81MAPK120.66762961
82SGK20.66101260
83MAP2K40.66024200
84ALK0.65187365
85PRPF4B0.65149066
86LCK0.65086809
87* JAK20.64774177
88TAOK10.64225766
89DMPK0.63256777
90PRKG20.63244999
91CAMK40.62929193
92GRK60.61940421
93PDGFRA0.61705630
94SIK30.61246955
95MAPK150.60560612
96BTK0.59326162
97BMPR20.58321344
98SGK10.57491424
99BMX0.56949570
100MAP3K50.56126244
101SIK10.55819838
102TESK10.52518480
103ABL20.52027805
104TXK0.51368986
105NME20.50201010
106JAK30.48111551
107MAP3K60.47154877
108CAMK10.46722208
109RPS6KA20.46646015
110STK110.46025172
111MAP2K60.45385375
112PRKCD0.45244438
113TESK20.44143661
114MAPK40.44135013
115SRC0.42594416
116PDGFRB0.42351092
117MAPK70.41630461
118TNK20.40093859
119KSR10.39588411
120ABL10.39075978
121MARK30.37916683
122PRKCG0.37762928
123SGK2230.37528965
124SGK4940.37528965
125RAF10.34917091
126DAPK30.33868344

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.86238560
2Lysosome_Homo sapiens_hsa041422.70641514
3Staphylococcus aureus infection_Homo sapiens_hsa051502.33839337
4Other glycan degradation_Homo sapiens_hsa005112.07024179
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.02952077
6Leishmaniasis_Homo sapiens_hsa051401.95632194
7* Osteoclast differentiation_Homo sapiens_hsa043801.93369678
8Synaptic vesicle cycle_Homo sapiens_hsa047211.89213622
9Tuberculosis_Homo sapiens_hsa051521.76093863
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66979912
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65996442
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.64002350
13B cell receptor signaling pathway_Homo sapiens_hsa046621.57456055
14Pertussis_Homo sapiens_hsa051331.55672667
15Phagosome_Homo sapiens_hsa041451.49923282
16Collecting duct acid secretion_Homo sapiens_hsa049661.45782650
17Olfactory transduction_Homo sapiens_hsa047401.37997215
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36720182
19Allograft rejection_Homo sapiens_hsa053301.35888245
20Type II diabetes mellitus_Homo sapiens_hsa049301.33782712
21Rheumatoid arthritis_Homo sapiens_hsa053231.33750952
22Graft-versus-host disease_Homo sapiens_hsa053321.30051703
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21388570
24Long-term potentiation_Homo sapiens_hsa047201.19591914
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17509256
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16609565
27Chemokine signaling pathway_Homo sapiens_hsa040621.16480906
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15415744
29Nicotine addiction_Homo sapiens_hsa050331.15209084
30Salivary secretion_Homo sapiens_hsa049701.15155564
31Morphine addiction_Homo sapiens_hsa050321.15028449
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12105815
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11235170
34Circadian entrainment_Homo sapiens_hsa047131.11066301
35Glutamatergic synapse_Homo sapiens_hsa047241.10891915
36Salmonella infection_Homo sapiens_hsa051321.09262620
37Malaria_Homo sapiens_hsa051441.08011084
38Autoimmune thyroid disease_Homo sapiens_hsa053201.07210346
39Acute myeloid leukemia_Homo sapiens_hsa052211.07096242
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.06149149
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05838787
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.05047207
43GABAergic synapse_Homo sapiens_hsa047271.04083070
44Gastric acid secretion_Homo sapiens_hsa049710.98633713
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97505314
46Renin secretion_Homo sapiens_hsa049240.97481057
47Hematopoietic cell lineage_Homo sapiens_hsa046400.97065375
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96967957
49Asthma_Homo sapiens_hsa053100.96701692
50Prion diseases_Homo sapiens_hsa050200.96407144
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94019987
52Cholinergic synapse_Homo sapiens_hsa047250.93186018
53Nitrogen metabolism_Homo sapiens_hsa009100.92821506
54African trypanosomiasis_Homo sapiens_hsa051430.92657866
55Glioma_Homo sapiens_hsa052140.91537016
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89517982
57Toxoplasmosis_Homo sapiens_hsa051450.88214672
58GnRH signaling pathway_Homo sapiens_hsa049120.87918242
59Legionellosis_Homo sapiens_hsa051340.87497148
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.86895648
61Endocytosis_Homo sapiens_hsa041440.86315493
62TNF signaling pathway_Homo sapiens_hsa046680.85971100
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85904612
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.85416358
65Oxytocin signaling pathway_Homo sapiens_hsa049210.83190237
66Hepatitis C_Homo sapiens_hsa051600.81390123
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81300046
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81295269
69Influenza A_Homo sapiens_hsa051640.81263227
70Insulin secretion_Homo sapiens_hsa049110.80862768
71Shigellosis_Homo sapiens_hsa051310.80418695
72Estrogen signaling pathway_Homo sapiens_hsa049150.79743486
73VEGF signaling pathway_Homo sapiens_hsa043700.79568042
74Platelet activation_Homo sapiens_hsa046110.79380405
75Long-term depression_Homo sapiens_hsa047300.78827043
76Dorso-ventral axis formation_Homo sapiens_hsa043200.78653498
77Viral myocarditis_Homo sapiens_hsa054160.77436081
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76191770
79Amphetamine addiction_Homo sapiens_hsa050310.74709150
80cAMP signaling pathway_Homo sapiens_hsa040240.71785408
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.71729167
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.70891926
83Chronic myeloid leukemia_Homo sapiens_hsa052200.70380258
84Dopaminergic synapse_Homo sapiens_hsa047280.70364156
85Pancreatic cancer_Homo sapiens_hsa052120.70309274
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70210772
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70078107
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.69960990
89Vibrio cholerae infection_Homo sapiens_hsa051100.69700812
90Calcium signaling pathway_Homo sapiens_hsa040200.68985851
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.68902186
92Amoebiasis_Homo sapiens_hsa051460.68373848
93Prolactin signaling pathway_Homo sapiens_hsa049170.67287989
94Type I diabetes mellitus_Homo sapiens_hsa049400.66946606
95Measles_Homo sapiens_hsa051620.66935726
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.65649775
97Apoptosis_Homo sapiens_hsa042100.65635521
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64879720
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63713317
100Cocaine addiction_Homo sapiens_hsa050300.61728781
101Bladder cancer_Homo sapiens_hsa052190.60877769
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60571337
103mTOR signaling pathway_Homo sapiens_hsa041500.60375068
104Renal cell carcinoma_Homo sapiens_hsa052110.60042788
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58333510
106Complement and coagulation cascades_Homo sapiens_hsa046100.58201219
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58111221
108HIF-1 signaling pathway_Homo sapiens_hsa040660.57857384
109Antigen processing and presentation_Homo sapiens_hsa046120.57829168
110Inositol phosphate metabolism_Homo sapiens_hsa005620.57412670
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57188474
112Non-small cell lung cancer_Homo sapiens_hsa052230.55846557
113Hepatitis B_Homo sapiens_hsa051610.54877335
114MAPK signaling pathway_Homo sapiens_hsa040100.54802475
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52915565
116ErbB signaling pathway_Homo sapiens_hsa040120.51824789
117Choline metabolism in cancer_Homo sapiens_hsa052310.51602695
118T cell receptor signaling pathway_Homo sapiens_hsa046600.51169332
119Rap1 signaling pathway_Homo sapiens_hsa040150.51077500

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