SIRPAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukotriene biosynthetic process (GO:0019370)6.07112650
2immunoglobulin mediated immune response (GO:0016064)5.47944507
3positive regulation of T cell cytokine production (GO:0002726)5.29661336
4synaptonemal complex assembly (GO:0007130)5.09844761
5piRNA metabolic process (GO:0034587)5.09096982
6male meiosis I (GO:0007141)5.03185964
7leukotriene metabolic process (GO:0006691)4.83124934
8definitive hemopoiesis (GO:0060216)4.80711286
9response to peptidoglycan (GO:0032494)4.60212034
10synaptonemal complex organization (GO:0070193)4.52990908
11chromosome organization involved in meiosis (GO:0070192)4.50900200
12DNA synthesis involved in DNA repair (GO:0000731)4.49665158
13regulation of interleukin-8 biosynthetic process (GO:0045414)4.48869720
14T-helper 1 type immune response (GO:0042088)4.43649846
15meiosis I (GO:0007127)4.34602566
16positive regulation of catecholamine secretion (GO:0033605)4.25410681
17positive regulation of prostaglandin secretion (GO:0032308)4.24243789
18positive regulation of interleukin-10 production (GO:0032733)4.22752476
19hyperosmotic salinity response (GO:0042538)4.21232346
20synapsis (GO:0007129)4.07669018
21aggressive behavior (GO:0002118)4.07359402
22B cell mediated immunity (GO:0019724)4.06010991
23detection of molecule of bacterial origin (GO:0032490)4.02006609
24regulation of prostaglandin secretion (GO:0032306)3.93395800
25sterol catabolic process (GO:0016127)3.92527927
26cholesterol catabolic process (GO:0006707)3.92527927
27regulation of penile erection (GO:0060405)3.86428000
28endothelium development (GO:0003158)3.79615307
29negative regulation of erythrocyte differentiation (GO:0045647)3.77928212
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.74979088
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.74979088
32modulation by symbiont of host immune response (GO:0052553)3.74979088
33positive regulation by symbiont of host defense response (GO:0052509)3.74979088
34modulation by symbiont of host defense response (GO:0052031)3.74979088
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.74979088
36fatty acid derivative biosynthetic process (GO:1901570)3.73387671
37icosanoid biosynthetic process (GO:0046456)3.73387671
38positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.67324897
39negative regulation of digestive system process (GO:0060457)3.67081339
40positive regulation of B cell differentiation (GO:0045579)3.66477178
41positive regulation of gamma-delta T cell activation (GO:0046645)3.63143404
42regulation of dendritic cell antigen processing and presentation (GO:0002604)3.60419153
43cellular response to nitric oxide (GO:0071732)3.59207904
44regulation of immunoglobulin secretion (GO:0051023)3.55450471
45regulation of T cell cytokine production (GO:0002724)3.55253104
46negative regulation of macrophage differentiation (GO:0045650)3.52242132
47meiotic nuclear division (GO:0007126)3.52234390
48regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.48938910
49regulation of erythrocyte differentiation (GO:0045646)3.46518923
50male meiosis (GO:0007140)3.44780974
51blood vessel maturation (GO:0001955)3.44742879
52negative regulation of interleukin-12 production (GO:0032695)3.42133921
53negative regulation of interleukin-8 production (GO:0032717)3.37899018
54cysteine metabolic process (GO:0006534)3.37548655
55defense response to protozoan (GO:0042832)3.34648123
56DNA methylation involved in gamete generation (GO:0043046)3.32045320
57germinal center formation (GO:0002467)3.29033101
58response to protozoan (GO:0001562)3.27447385
59detection of external biotic stimulus (GO:0098581)3.25397371
60regulation of interleukin-10 production (GO:0032653)3.20588763
61neutrophil activation involved in immune response (GO:0002283)3.18939960
62detection of other organism (GO:0098543)3.18591562
63positive regulation of lamellipodium assembly (GO:0010592)3.17591550
64Arp2/3 complex-mediated actin nucleation (GO:0034314)3.17546641
65unsaturated fatty acid biosynthetic process (GO:0006636)3.16985877
66positive regulation of uterine smooth muscle contraction (GO:0070474)3.16330944
67negative regulation of cell killing (GO:0031342)3.15626973
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.15626973
69cellular response to reactive nitrogen species (GO:1902170)3.15552658
70mature B cell differentiation involved in immune response (GO:0002313)3.15528690
71antigen processing and presentation of endogenous antigen (GO:0019883)3.15077352
72positive regulation of antigen processing and presentation (GO:0002579)3.14221741
73positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.11671023
74positive regulation of cytokine production involved in immune response (GO:0002720)3.11185327
75drinking behavior (GO:0042756)3.10920775
76positive regulation of interleukin-2 production (GO:0032743)3.10131009
77regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.09989955
78positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.05250122
79neuron remodeling (GO:0016322)3.02310645
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.98848516
81detection of biotic stimulus (GO:0009595)2.96128448
82fat-soluble vitamin biosynthetic process (GO:0042362)2.92568722
83cellular extravasation (GO:0045123)2.91851394
84positive regulation of erythrocyte differentiation (GO:0045648)2.90016482
85sleep (GO:0030431)2.89229972
86regulation of macrophage differentiation (GO:0045649)2.89199120
87positive regulation of T cell mediated immunity (GO:0002711)2.88425500
88positive regulation of megakaryocyte differentiation (GO:0045654)2.87941587
89positive regulation of lamellipodium organization (GO:1902745)2.86966948
90regulation of hypersensitivity (GO:0002883)2.84866798
91regulation of DNA damage checkpoint (GO:2000001)2.83389020
92positive regulation of macrophage cytokine production (GO:0060907)2.83153504
93positive regulation of digestive system process (GO:0060456)2.82542654
94positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.82359201
95regulation of female receptivity (GO:0045924)2.81532233
96positive regulation of tumor necrosis factor production (GO:0032760)2.80864791
97response to host immune response (GO:0052572)2.78519421
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78519421
99negative regulation of necroptotic process (GO:0060546)2.76477237
100detection of bacterium (GO:0016045)2.73999052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.33555389
2SCL_19346495_ChIP-Seq_HPC-7_Human6.10840361
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.60970862
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.18777474
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.66174979
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.98716345
7RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.97207160
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.93545951
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.61721423
10RUNX_20019798_ChIP-Seq_JUKART_Human2.56792776
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54538295
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.49665843
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.26289264
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.25273602
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20654390
16CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.19525351
17MYB_26560356_Chip-Seq_TH2_Human2.12061911
18LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.09297204
19VDR_24763502_ChIP-Seq_THP-1_Human2.03878595
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02442349
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97870340
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95916043
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76080400
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74775899
25VDR_21846776_ChIP-Seq_THP-1_Human1.72470134
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67081107
27PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65839604
28SPI1_23127762_ChIP-Seq_K562_Human1.65455344
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62934491
30SPI1_20517297_ChIP-Seq_HL60_Human1.62030681
31IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60818728
32GATA1_19941826_ChIP-Seq_K562_Human1.60654241
33SPI1_23547873_ChIP-Seq_NB4_Human1.59895281
34ELF1_20517297_ChIP-Seq_JURKAT_Human1.52534776
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.50767271
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.50734394
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.46310157
38GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44370509
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43565357
40IGF1R_20145208_ChIP-Seq_DFB_Human1.42825034
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41059358
42MAF_26560356_Chip-Seq_TH1_Human1.40156788
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39603498
44YY1_22570637_ChIP-Seq_MALME-3M_Human1.39371226
45UTX_26944678_Chip-Seq_JUKART_Human1.37147560
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33360701
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33204796
48EGR1_19032775_ChIP-ChIP_M12_Human1.32058983
49MYB_26560356_Chip-Seq_TH1_Human1.31716878
50VDR_24787735_ChIP-Seq_THP-1_Human1.31492226
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29653389
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26307582
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25680355
54PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24586750
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24292355
56BCL6_27268052_Chip-Seq_Bcells_Human1.23593461
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23281545
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22859903
59GATA2_21666600_ChIP-Seq_HMVEC_Human1.22598175
60KDM2B_26808549_Chip-Seq_DND41_Human1.21290443
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.20584659
62GATA2_19941826_ChIP-Seq_K562_Human1.20362402
63PU_27001747_Chip-Seq_BMDM_Mouse1.19942000
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18695691
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18013779
66EZH2_22144423_ChIP-Seq_EOC_Human1.15615488
67CTCF_26484167_Chip-Seq_Bcells_Mouse1.13102760
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.12652325
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10486953
70TCF7_22412390_ChIP-Seq_EML_Mouse1.10157701
71GATA3_26560356_Chip-Seq_TH2_Human1.09077290
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07202889
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.06807355
74MAF_26560356_Chip-Seq_TH2_Human1.06212546
75GATA3_27048872_Chip-Seq_THYMUS_Human1.04059719
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03413022
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01107018
78TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96919690
79GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95077718
80MYC_22102868_ChIP-Seq_BL_Human0.93069632
81RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92711465
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92013962
83PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91440268
84STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90424832
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89089944
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85793517
87STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85694351
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83119612
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83117154
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.81917070
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81542888
92BCOR_27268052_Chip-Seq_Bcells_Human0.81163009
93P300_27268052_Chip-Seq_Bcells_Human0.81113067
94GATA3_26560356_Chip-Seq_TH1_Human0.80009815
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79598112
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77837201
97GATA1_19941827_ChIP-Seq_MEL86_Mouse0.77055020
98BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.72912865
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.71782026
100AR_20517297_ChIP-Seq_VCAP_Human0.71285401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.05728188
2MP0000465_gastrointestinal_hemorrhage3.60191599
3MP0002277_abnormal_respiratory_mucosa3.41725458
4MP0003183_abnormal_peptide_metabolism3.32035143
5MP0003724_increased_susceptibility_to3.27194134
6MP0002148_abnormal_hypersensitivity_rea3.15203809
7MP0005464_abnormal_platelet_physiology3.10493232
8MP0003436_decreased_susceptibility_to2.67554042
9MP0005671_abnormal_response_to2.59041323
10MP0003011_delayed_dark_adaptation2.53822660
11MP0009785_altered_susceptibility_to2.48207222
12MP0009764_decreased_sensitivity_to2.46376637
13MP0009278_abnormal_bone_marrow2.40788060
14MP0002419_abnormal_innate_immunity2.27790231
15MP0001835_abnormal_antigen_presentation2.27000604
16MP0005025_abnormal_response_to2.24088775
17MP0003191_abnormal_cellular_cholesterol2.21409111
18MP0001790_abnormal_immune_system2.16082937
19MP0005387_immune_system_phenotype2.16082937
20MP0003300_gastrointestinal_ulcer2.14694453
21MP0003646_muscle_fatigue2.12758053
22MP0008877_abnormal_DNA_methylation2.11202693
23MP0002822_catalepsy2.10922984
24MP0001800_abnormal_humoral_immune2.07300310
25MP0005397_hematopoietic_system_phenotyp2.05055029
26MP0001545_abnormal_hematopoietic_system2.05055029
27MP0006054_spinal_hemorrhage2.03989080
28MP0002452_abnormal_antigen_presenting1.98606075
29MP0000685_abnormal_immune_system1.86002586
30MP0001819_abnormal_immune_cell1.84516856
31MP0002420_abnormal_adaptive_immunity1.82921367
32MP0005000_abnormal_immune_tolerance1.80398187
33MP0002723_abnormal_immune_serum1.80104768
34MP0004019_abnormal_vitamin_homeostasis1.73669988
35MP0002405_respiratory_system_inflammati1.72521725
36MP0004858_abnormal_nervous_system1.63978136
37MP0002398_abnormal_bone_marrow1.58337149
38MP0003806_abnormal_nucleotide_metabolis1.49991735
39MP0000689_abnormal_spleen_morphology1.46281528
40MP0009384_cardiac_valve_regurgitation1.46247456
41MP0000716_abnormal_immune_system1.44843961
42MP0003315_abnormal_perineum_morphology1.43889988
43MP0003075_altered_response_to1.40948917
44MP0009765_abnormal_xenobiotic_induced1.40315413
45MP0008469_abnormal_protein_level1.39913711
46MP0001533_abnormal_skeleton_physiology1.37370977
47MP0008058_abnormal_DNA_repair1.36655272
48MP0002132_abnormal_respiratory_system1.33810272
49MP0004233_abnormal_muscle_weight1.31085685
50MP0000343_altered_response_to1.30364188
51MP0002163_abnormal_gland_morphology1.29707691
52MP0006082_CNS_inflammation1.28104320
53MP0000516_abnormal_urinary_system1.27430908
54MP0005367_renal/urinary_system_phenotyp1.27430908
55MP0003763_abnormal_thymus_physiology1.25032688
56MP0003690_abnormal_glial_cell1.24253998
57MP0002722_abnormal_immune_system1.22822847
58MP0001845_abnormal_inflammatory_respons1.22505660
59MP0002429_abnormal_blood_cell1.21604972
60MP0002095_abnormal_skin_pigmentation1.17904932
61MP0003172_abnormal_lysosome_physiology1.15757815
62MP0005167_abnormal_blood-brain_barrier1.11649872
63MP0003221_abnormal_cardiomyocyte_apopto1.09273040
64MP0000383_abnormal_hair_follicle1.05988618
65MP0003866_abnormal_defecation1.02854409
66MP0005584_abnormal_enzyme/coenzyme_acti0.96516453
67MP0002166_altered_tumor_susceptibility0.92744777
68MP0005410_abnormal_fertilization0.92354053
69MP0002998_abnormal_bone_remodeling0.92339920
70MP0003828_pulmonary_edema0.92229820
71MP0003448_altered_tumor_morphology0.91412894
72MP0005319_abnormal_enzyme/_coenzyme0.91318635
73MP0001851_eye_inflammation0.90235632
74MP0010155_abnormal_intestine_physiology0.87970262
75MP0001119_abnormal_female_reproductive0.87295272
76MP0010386_abnormal_urinary_bladder0.85197503
77MP0009763_increased_sensitivity_to0.84241349
78MP0001764_abnormal_homeostasis0.83961290
79MP0008004_abnormal_stomach_pH0.83643683
80MP0000230_abnormal_systemic_arterial0.83544339
81MP0001881_abnormal_mammary_gland0.83446866
82MP0003795_abnormal_bone_structure0.82807894
83MP0003699_abnormal_female_reproductive0.80576996
84MP0002006_tumorigenesis0.80156478
85MP0005646_abnormal_pituitary_gland0.79685445
86MP0000371_diluted_coat_color0.78197987
87MP0001929_abnormal_gametogenesis0.77184248
88MP0005390_skeleton_phenotype0.76564078
89MP0000372_irregular_coat_pigmentation0.76278275
90MP0005164_abnormal_response_to0.74015960
91MP0002210_abnormal_sex_determination0.73936372
92MP0003656_abnormal_erythrocyte_physiolo0.73856593
93MP0001440_abnormal_grooming_behavior0.73450635
94MP0005220_abnormal_exocrine_pancreas0.72053014
95MP0002160_abnormal_reproductive_system0.71766739
96MP0002075_abnormal_coat/hair_pigmentati0.70731908
97MP0003698_abnormal_male_reproductive0.69679640
98MP0009333_abnormal_splenocyte_physiolog0.68549118
99MP0005666_abnormal_adipose_tissue0.67860945
100MP0001145_abnormal_male_reproductive0.67656709

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)5.62968124
2Orchitis (HP:0100796)5.08650316
3Elevated erythrocyte sedimentation rate (HP:0003565)4.78131879
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.57268734
5Myositis (HP:0100614)4.56413718
6Peritonitis (HP:0002586)4.11505591
7Abnormality of the lumbar spine (HP:0100712)4.09666115
8Methylmalonic aciduria (HP:0012120)4.05730882
9Chronic obstructive pulmonary disease (HP:0006510)4.00381192
10Obstructive lung disease (HP:0006536)4.00381192
11Leukocytosis (HP:0001974)3.99912006
12Thoracic kyphosis (HP:0002942)3.97179730
13Tubulointerstitial nephritis (HP:0001970)3.76855349
14Abnormality of glycolipid metabolism (HP:0010969)3.67815967
15Abnormality of liposaccharide metabolism (HP:0010968)3.67815967
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.67815967
17Eczematoid dermatitis (HP:0000976)3.61457770
18Prolonged bleeding time (HP:0003010)3.55309990
19Recurrent abscess formation (HP:0002722)3.43545582
20Peripheral hypomyelination (HP:0007182)3.42406062
21Amyloidosis (HP:0011034)3.40922634
22Anhidrosis (HP:0000970)3.35152030
23Deformed sella turcica (HP:0002681)3.28374618
24Abnormality of the thoracic spine (HP:0100711)3.24564358
25Recurrent bacterial skin infections (HP:0005406)3.23517506
26Abnormality of the peritoneum (HP:0002585)3.12980534
27Epistaxis (HP:0000421)3.11544491
28Petechiae (HP:0000967)3.04006753
29Cellulitis (HP:0100658)2.99680834
30Abnormality of macrophages (HP:0004311)2.99444235
31Acne (HP:0001061)2.98543306
32Purpura (HP:0000979)2.96232599
33Increased IgM level (HP:0003496)2.96078100
34Dysostosis multiplex (HP:0000943)2.95059772
35Spontaneous hematomas (HP:0007420)2.90206025
36Chest pain (HP:0100749)2.89692763
37Optic neuritis (HP:0100653)2.85568142
38Retrobulbar optic neuritis (HP:0100654)2.85568142
39Abnormal rod and cone electroretinograms (HP:0008323)2.85514366
40Hypertensive crisis (HP:0100735)2.80636299
41Lower limb hyperreflexia (HP:0002395)2.76711315
42Aplastic anemia (HP:0001915)2.75662071
43Recurrent fungal infections (HP:0002841)2.66260326
44Abnormal platelet volume (HP:0011876)2.66138702
45Premature loss of primary teeth (HP:0006323)2.63490389
46Vasculitis (HP:0002633)2.61518728
47Thickened calvaria (HP:0002684)2.60025172
48Recurrent gram-negative bacterial infections (HP:0005420)2.52196668
49Increased mean platelet volume (HP:0011877)2.51101810
50Seborrheic dermatitis (HP:0001051)2.48867250
51Vertebral arch anomaly (HP:0008438)2.48527321
52Periodontitis (HP:0000704)2.48224846
53Urticaria (HP:0001025)2.48163257
54Slow saccadic eye movements (HP:0000514)2.45500099
55Hyperthyroidism (HP:0000836)2.45169908
56Mediastinal lymphadenopathy (HP:0100721)2.44212665
57Recurrent bronchitis (HP:0002837)2.36481792
58Stomatitis (HP:0010280)2.35919442
59Menorrhagia (HP:0000132)2.34916032
60Mucopolysacchariduria (HP:0008155)2.32875702
61Urinary glycosaminoglycan excretion (HP:0003541)2.32875702
62Vertigo (HP:0002321)2.30862288
63Decreased central vision (HP:0007663)2.26467859
64Keratoconjunctivitis sicca (HP:0001097)2.22231257
65Broad alveolar ridges (HP:0000187)2.18417841
66Abnormality of polysaccharide metabolism (HP:0011012)2.16810569
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16810569
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16810569
69Atelectasis (HP:0100750)2.15389020
70Episodic fever (HP:0001954)2.13845026
71Protuberant abdomen (HP:0001538)2.12548805
72Hypoparathyroidism (HP:0000829)2.11048295
73Neuronal loss in central nervous system (HP:0002529)2.10519222
74Methylmalonic acidemia (HP:0002912)2.09811703
75Abnormality of the pleura (HP:0002103)2.07532042
76Aplasia/Hypoplasia of the thymus (HP:0010515)2.07206673
77Ketoacidosis (HP:0001993)2.07164480
78Dyskinesia (HP:0100660)2.05960228
79Gingivitis (HP:0000230)2.03983329
80Ketosis (HP:0001946)2.03741876
81Beaking of vertebral bodies (HP:0004568)2.02544368
82Autoimmune thrombocytopenia (HP:0001973)2.01713170
83Pulmonary infiltrates (HP:0002113)1.98736707
84Abnormality of the sella turcica (HP:0002679)1.98656024
85Gastrointestinal infarctions (HP:0005244)1.98407120
86Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93871402
87Dicarboxylic aciduria (HP:0003215)1.93871402
88Keratoconjunctivitis (HP:0001096)1.93714922
89Microcytic anemia (HP:0001935)1.92401328
90Muscle fibrillation (HP:0010546)1.91770598
91Spontaneous abortion (HP:0005268)1.91031738
92Aplasia/Hypoplasia of the fovea (HP:0008060)1.89106771
93Hypoplasia of the fovea (HP:0007750)1.89106771
94Pustule (HP:0200039)1.88562350
95Flattened epiphyses (HP:0003071)1.88558841
96Severe global developmental delay (HP:0011344)1.86923865
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85502114
98Degeneration of the lateral corticospinal tracts (HP:0002314)1.85502114
99Abnormality of the basal ganglia (HP:0002134)1.84707017
100Metaphyseal cupping (HP:0003021)1.81208297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN17.35641211
2BCKDK4.58581566
3RIPK42.61398993
4MAP3K12.28192742
5TESK12.27432693
6GRK62.22298471
7KDR2.21047413
8MAP2K72.16466823
9DYRK1B2.10375886
10IRAK42.02749992
11TAOK31.89991548
12TESK21.89783085
13NEK91.81989440
14TXK1.75429793
15KIT1.70326681
16VRK21.66491114
17CDK191.65815104
18JAK31.63026476
19FGR1.56475595
20BLK1.55637704
21IRAK31.54402412
22MARK21.51573280
23MAP2K31.50422335
24MAP4K11.49264274
25FES1.45544771
26PRKD21.41580586
27TNK21.40149074
28CAMK41.35943531
29MAP3K71.34688092
30CSK1.33855259
31MATK1.30726972
32ADRBK21.26451235
33SIK21.26085240
34PTK2B1.26043688
35CDK121.22386029
36MAP3K31.16316131
37TYK21.15821093
38YES11.07881549
39IRAK11.05531395
40SYK1.03313329
41ZAP701.00817355
42CAMKK20.97539491
43JAK20.97447578
44EPHA30.93134218
45IRAK20.92955578
46DAPK20.91782679
47MARK30.89176078
48CAMK10.87083803
49TBK10.86583123
50LYN0.86559061
51TIE10.85907387
52MAPK70.85885071
53EPHB10.76124214
54LRRK20.75136913
55TAOK20.74053231
56LCK0.73474084
57HCK0.69885007
58IKBKE0.68925169
59CSF1R0.68643124
60BMPR20.68072544
61PRPF4B0.67003905
62WNK10.66594608
63BTK0.65187392
64TAOK10.63541119
65NLK0.62676889
66MAP3K110.62515613
67MAP3K140.62507289
68PDK20.59373870
69FER0.59132773
70GRK50.58124314
71FYN0.57535804
72CDK90.56333561
73GRK70.56176211
74PIM10.50141850
75PKN10.49757098
76NTRK20.48491945
77CCNB10.47978104
78ADRBK10.47531878
79VRK10.46846079
80RPS6KA60.46437191
81ABL20.45999642
82IKBKB0.45861214
83IGF1R0.44116696
84PRKCQ0.43658526
85PRKG20.43225276
86RPS6KL10.42730831
87RPS6KC10.42730831
88FLT30.42692776
89AKT20.41646355
90TGFBR20.39612909
91CDK60.39134938
92OXSR10.37797023
93CAMKK10.37184111
94SRPK10.36770946
95PRKCD0.34918447
96PTK60.34694536
97PRKCZ0.33376049
98STK380.33310411
99PRKD10.31746128
100DYRK30.30652061

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.33413124
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.12315575
3Osteoclast differentiation_Homo sapiens_hsa043802.86005954
4Non-homologous end-joining_Homo sapiens_hsa034502.81847461
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.50826884
6Leishmaniasis_Homo sapiens_hsa051402.38581521
7Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.35708578
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.35054931
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.14521658
10Tuberculosis_Homo sapiens_hsa051522.09499081
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08917294
12Staphylococcus aureus infection_Homo sapiens_hsa051502.04855567
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04591392
14B cell receptor signaling pathway_Homo sapiens_hsa046621.97847934
15TNF signaling pathway_Homo sapiens_hsa046681.94148680
16Allograft rejection_Homo sapiens_hsa053301.89644079
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.83652971
18Malaria_Homo sapiens_hsa051441.83023436
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82414936
20Autoimmune thyroid disease_Homo sapiens_hsa053201.71550187
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70062614
22Graft-versus-host disease_Homo sapiens_hsa053321.61637072
23Hematopoietic cell lineage_Homo sapiens_hsa046401.57824062
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55780709
25Legionellosis_Homo sapiens_hsa051341.51041712
26Asthma_Homo sapiens_hsa053101.49197404
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46266942
28Antigen processing and presentation_Homo sapiens_hsa046121.41306546
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37023638
30Platelet activation_Homo sapiens_hsa046111.36681525
31Type I diabetes mellitus_Homo sapiens_hsa049401.34144065
32Toxoplasmosis_Homo sapiens_hsa051451.33818908
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33699556
34Measles_Homo sapiens_hsa051621.25141524
35Rheumatoid arthritis_Homo sapiens_hsa053231.24111722
36Herpes simplex infection_Homo sapiens_hsa051681.23680026
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.22910081
38Salmonella infection_Homo sapiens_hsa051321.20854079
39Phagosome_Homo sapiens_hsa041451.20718028
40Pertussis_Homo sapiens_hsa051331.19031239
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16830088
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.14811515
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.14536724
44Chemokine signaling pathway_Homo sapiens_hsa040621.14037954
45Influenza A_Homo sapiens_hsa051641.11828679
46Regulation of autophagy_Homo sapiens_hsa041401.09829784
47Lysosome_Homo sapiens_hsa041421.07881788
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99214708
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99098527
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95989996
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93489304
52Shigellosis_Homo sapiens_hsa051310.93114147
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93100290
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91864552
55Homologous recombination_Homo sapiens_hsa034400.90430836
56T cell receptor signaling pathway_Homo sapiens_hsa046600.89190085
57Apoptosis_Homo sapiens_hsa042100.86639993
58Acute myeloid leukemia_Homo sapiens_hsa052210.84072304
59Dorso-ventral axis formation_Homo sapiens_hsa043200.84064260
60Hepatitis C_Homo sapiens_hsa051600.79799391
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.79360563
62African trypanosomiasis_Homo sapiens_hsa051430.79263657
63Viral myocarditis_Homo sapiens_hsa054160.76174782
64Epstein-Barr virus infection_Homo sapiens_hsa051690.74818041
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.74378332
66Amoebiasis_Homo sapiens_hsa051460.72092338
67Hepatitis B_Homo sapiens_hsa051610.72082754
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70890414
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70700549
70Primary immunodeficiency_Homo sapiens_hsa053400.68789261
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67627351
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.64212019
73VEGF signaling pathway_Homo sapiens_hsa043700.62450218
74Renin secretion_Homo sapiens_hsa049240.59878004
75Oxytocin signaling pathway_Homo sapiens_hsa049210.59086007
76HTLV-I infection_Homo sapiens_hsa051660.58773181
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57063440
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54146108
79Viral carcinogenesis_Homo sapiens_hsa052030.49392092
80Inositol phosphate metabolism_Homo sapiens_hsa005620.49249642
81Arachidonic acid metabolism_Homo sapiens_hsa005900.49044121
82mTOR signaling pathway_Homo sapiens_hsa041500.48430145
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48346257
84Tryptophan metabolism_Homo sapiens_hsa003800.46031778
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44083207
86HIF-1 signaling pathway_Homo sapiens_hsa040660.43962573
87Small cell lung cancer_Homo sapiens_hsa052220.42959687
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.39316662
89Collecting duct acid secretion_Homo sapiens_hsa049660.38677011
90Notch signaling pathway_Homo sapiens_hsa043300.36752979
91Oocyte meiosis_Homo sapiens_hsa041140.35392538
92Non-small cell lung cancer_Homo sapiens_hsa052230.33271893
93Glutathione metabolism_Homo sapiens_hsa004800.31098556
94Endocytosis_Homo sapiens_hsa041440.30236853
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.29821883
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28651648
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28564832
98Propanoate metabolism_Homo sapiens_hsa006400.28033983
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27892023
100beta-Alanine metabolism_Homo sapiens_hsa004100.27857959

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