SIRPD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.52148522
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.52148522
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.52148522
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.52148522
5modulation by symbiont of host immune response (GO:0052553)6.52148522
6positive regulation by symbiont of host defense response (GO:0052509)6.52148522
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.48793179
8detection of molecule of bacterial origin (GO:0032490)5.77769648
9macrophage activation involved in immune response (GO:0002281)5.64357040
10neutrophil activation involved in immune response (GO:0002283)5.44825026
11positive regulation of gamma-delta T cell activation (GO:0046645)5.41001292
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.39622772
13cellular extravasation (GO:0045123)5.20605791
14response to peptidoglycan (GO:0032494)5.20010572
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.05096667
16negative regulation of cell killing (GO:0031342)5.05096667
17detection of other organism (GO:0098543)4.95363312
18regulation of interferon-beta biosynthetic process (GO:0045357)4.92186265
19microglial cell activation (GO:0001774)4.85208938
20detection of external biotic stimulus (GO:0098581)4.78964784
21negative regulation of interleukin-12 production (GO:0032695)4.63660411
22regulation of B cell receptor signaling pathway (GO:0050855)4.52398212
23macrophage activation (GO:0042116)4.46067844
24neutrophil activation (GO:0042119)4.35236791
25detection of bacterium (GO:0016045)4.32907153
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.31902319
27response to host immune response (GO:0052572)4.31902319
28detection of biotic stimulus (GO:0009595)4.27515661
29neutrophil mediated immunity (GO:0002446)4.23169322
30regulation of gamma-delta T cell activation (GO:0046643)4.13393130
31myeloid cell activation involved in immune response (GO:0002275)4.12438651
32respiratory burst (GO:0045730)4.04566315
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.00389095
34positive regulation of mast cell activation (GO:0033005)3.97496382
35granulocyte activation (GO:0036230)3.95413654
36leukocyte migration involved in inflammatory response (GO:0002523)3.93744302
37response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.91845292
38response to host (GO:0075136)3.91845292
39response to host defenses (GO:0052200)3.91845292
40regulation of mast cell degranulation (GO:0043304)3.91844254
41regulation of T-helper 2 cell differentiation (GO:0045628)3.91027379
42antigen processing and presentation of endogenous antigen (GO:0019883)3.83340606
43leukocyte aggregation (GO:0070486)3.79963157
44antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.75093614
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.72823117
46regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.72164244
47production of molecular mediator involved in inflammatory response (GO:0002532)3.68641235
48regulation of mast cell activation involved in immune response (GO:0033006)3.65666536
49immunoglobulin mediated immune response (GO:0016064)3.64880505
50myeloid leukocyte mediated immunity (GO:0002444)3.58828823
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.57219370
52positive regulation of mast cell activation involved in immune response (GO:0033008)3.55403879
53positive regulation of mast cell degranulation (GO:0043306)3.55403879
54regulation of gamma-delta T cell differentiation (GO:0045586)3.53851303
55regulation of myeloid leukocyte mediated immunity (GO:0002886)3.53038904
56regulation of mast cell activation (GO:0033003)3.51319104
57positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.48002774
58cell wall macromolecule catabolic process (GO:0016998)3.40325545
59lipopolysaccharide-mediated signaling pathway (GO:0031663)3.36742363
60leukocyte degranulation (GO:0043299)3.35700249
61regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.34966640
62regulation of leukocyte degranulation (GO:0043300)3.32576954
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32009897
64fusion of sperm to egg plasma membrane (GO:0007342)3.25715723
65negative regulation of T cell mediated immunity (GO:0002710)3.25303891
66negative regulation of leukocyte mediated immunity (GO:0002704)3.24644053
67regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.18870628
68response to muramyl dipeptide (GO:0032495)3.17952113
69positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.13261543
70myeloid leukocyte activation (GO:0002274)3.13021434
71positive regulation of cellular amide metabolic process (GO:0034250)3.07818877
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.07042166
73defense response to protozoan (GO:0042832)3.05128948
74germinal center formation (GO:0002467)3.04140928
75positive regulation of interferon-alpha production (GO:0032727)3.03875819
76response to interleukin-15 (GO:0070672)3.03201048
77regulation of interleukin-8 biosynthetic process (GO:0045414)3.02543539
78neutrophil chemotaxis (GO:0030593)3.01274270
79B cell receptor signaling pathway (GO:0050853)2.99877197
80positive regulation of type 2 immune response (GO:0002830)2.99372440
81acrosome reaction (GO:0007340)2.98258178
82positive regulation of toll-like receptor signaling pathway (GO:0034123)2.97283899
83cell wall macromolecule metabolic process (GO:0044036)2.96102253
84T-helper 1 type immune response (GO:0042088)2.96099185
85negative regulation of interleukin-6 production (GO:0032715)2.96089854
86neutrophil migration (GO:1990266)2.93463571
87antigen processing and presentation via MHC class Ib (GO:0002475)2.92728304
88regulation of tolerance induction (GO:0002643)2.91968129
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91953130
90regulation of regulated secretory pathway (GO:1903305)2.90353732
91interferon-gamma-mediated signaling pathway (GO:0060333)2.88938653
92regulation of interferon-alpha production (GO:0032647)2.88545145
93mast cell activation (GO:0045576)2.83868917
94cellular response to type I interferon (GO:0071357)2.82953490
95type I interferon signaling pathway (GO:0060337)2.82953490
96I-kappaB phosphorylation (GO:0007252)2.82883511
97B cell mediated immunity (GO:0019724)2.81771422
98regulation of macrophage cytokine production (GO:0010935)2.81063608
99sperm motility (GO:0030317)2.79874788
100response to type I interferon (GO:0034340)2.79763161

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.87889750
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.87041022
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.26712671
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.45294853
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.41349269
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.24176695
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08621499
8RUNX_20019798_ChIP-Seq_JUKART_Human2.85893822
9SPI1_23127762_ChIP-Seq_K562_Human2.74349292
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67132236
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64870064
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63874166
13SPI1_23547873_ChIP-Seq_NB4_Human2.50021087
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48039442
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.47264271
16VDR_24763502_ChIP-Seq_THP-1_Human2.43182766
17VDR_24787735_ChIP-Seq_THP-1_Human2.36212584
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18892463
19MYB_26560356_Chip-Seq_TH2_Human2.18764175
20SCL_19346495_ChIP-Seq_HPC-7_Human2.18101419
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17431664
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16347411
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10992707
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01792335
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99756325
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.94773274
27VDR_21846776_ChIP-Seq_THP-1_Human1.93932393
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88786508
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.88325209
30MAF_26560356_Chip-Seq_TH1_Human1.86558800
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83110433
32MYB_26560356_Chip-Seq_TH1_Human1.79513418
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.75386043
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72481851
35VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.68673150
36UTX_26944678_Chip-Seq_JUKART_Human1.65742291
37SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61780676
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60611900
39GATA3_27048872_Chip-Seq_THYMUS_Human1.60344202
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55272438
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.55107267
42TCF7_22412390_ChIP-Seq_EML_Mouse1.54133049
43* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52988304
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48156714
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.45044271
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44744739
47PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44420235
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.43756410
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43628380
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38602582
51GATA3_26560356_Chip-Seq_TH2_Human1.37515190
52MAF_26560356_Chip-Seq_TH2_Human1.34825368
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33269290
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31407765
55GATA1_19941826_ChIP-Seq_K562_Human1.31398336
56PU_27001747_Chip-Seq_BMDM_Mouse1.30598232
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27746865
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26622116
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23895779
60KDM2B_26808549_Chip-Seq_DND41_Human1.23435603
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22561561
62BCL6_27268052_Chip-Seq_Bcells_Human1.20491992
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19916797
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19126539
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17275811
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15639458
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15139085
68BCOR_27268052_Chip-Seq_Bcells_Human1.12694650
69CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11452913
70SMRT_27268052_Chip-Seq_Bcells_Human1.10591338
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09567720
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09311055
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08413076
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08250818
75MYC_22102868_ChIP-Seq_BL_Human1.07630712
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05870205
77LXR_22292898_ChIP-Seq_THP-1_Human1.05803663
78SPI1_20517297_ChIP-Seq_HL60_Human1.04771471
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04766064
80GATA2_19941826_ChIP-Seq_K562_Human1.04676487
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03871096
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.00969345
83GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00352196
84GATA2_21666600_ChIP-Seq_HMVEC_Human0.98921127
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97416318
86KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96958757
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96740194
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94783269
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94783269
90GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94019657
91GATA1_22025678_ChIP-Seq_K562_Human0.91599273
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91508970
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89876521
94P300_27268052_Chip-Seq_Bcells_Human0.88575271
95PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87824658
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87692155
97DROSHA_22980978_ChIP-Seq_HELA_Human0.84106887
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82503151
99RAC3_21632823_ChIP-Seq_H3396_Human0.80896890
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80217065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.30381346
2MP0003436_decreased_susceptibility_to3.95604966
3MP0003303_peritoneal_inflammation3.94153145
4MP0001835_abnormal_antigen_presentation3.72619840
5MP0002419_abnormal_innate_immunity3.20558918
6MP0005410_abnormal_fertilization2.97093644
7MP0009785_altered_susceptibility_to2.77967913
8MP0005025_abnormal_response_to2.74367536
9MP0001800_abnormal_humoral_immune2.63071478
10MP0005000_abnormal_immune_tolerance2.58979140
11MP0006082_CNS_inflammation2.58193549
12MP0005671_abnormal_response_to2.56478823
13MP0000685_abnormal_immune_system2.55013367
14MP0002723_abnormal_immune_serum2.43122497
15MP0002452_abnormal_antigen_presenting2.36353616
16MP0005387_immune_system_phenotype2.36084279
17MP0001790_abnormal_immune_system2.36084279
18MP0002132_abnormal_respiratory_system2.35964790
19MP0003172_abnormal_lysosome_physiology2.35340516
20MP0002420_abnormal_adaptive_immunity2.25225952
21MP0001819_abnormal_immune_cell2.22814970
22MP0001533_abnormal_skeleton_physiology2.22329315
23MP0005451_abnormal_body_composition2.21725912
24MP0008260_abnormal_autophagy2.18318568
25MP0002148_abnormal_hypersensitivity_rea2.14068702
26MP0003191_abnormal_cellular_cholesterol2.11132679
27MP0003828_pulmonary_edema2.05153154
28MP0003300_gastrointestinal_ulcer2.03228361
29MP0009278_abnormal_bone_marrow1.93279373
30MP0005464_abnormal_platelet_physiology1.92272180
31MP0009764_decreased_sensitivity_to1.87463439
32MP0002405_respiratory_system_inflammati1.80782586
33MP0005310_abnormal_salivary_gland1.69949428
34MP0000716_abnormal_immune_system1.65611504
35MP0003878_abnormal_ear_physiology1.65120414
36MP0005377_hearing/vestibular/ear_phenot1.65120414
37MP0001845_abnormal_inflammatory_respons1.64723021
38MP0004883_abnormal_blood_vessel1.60966927
39MP0000569_abnormal_digit_pigmentation1.60855141
40MP0002398_abnormal_bone_marrow1.60775715
41MP0005397_hematopoietic_system_phenotyp1.55678024
42MP0001545_abnormal_hematopoietic_system1.55678024
43MP0004947_skin_inflammation1.54795373
44MP0004510_myositis1.53940213
45MP0003075_altered_response_to1.42204350
46MP0005164_abnormal_response_to1.40968717
47MP0008469_abnormal_protein_level1.39812981
48MP0002722_abnormal_immune_system1.36615333
49MP0000689_abnormal_spleen_morphology1.33471321
50MP0010155_abnormal_intestine_physiology1.31692412
51MP0003763_abnormal_thymus_physiology1.29042808
52MP0002429_abnormal_blood_cell1.27681536
53MP0002998_abnormal_bone_remodeling1.26387861
54MP0002277_abnormal_respiratory_mucosa1.24216508
55MP0003183_abnormal_peptide_metabolism1.23665523
56MP0004381_abnormal_hair_follicle1.23218520
57MP0000465_gastrointestinal_hemorrhage1.23120674
58MP0005058_abnormal_lysosome_morphology1.17953271
59MP0008004_abnormal_stomach_pH1.17563902
60MP0003690_abnormal_glial_cell1.16414271
61MP0005166_decreased_susceptibility_to1.14847195
62MP0000703_abnormal_thymus_morphology1.11767843
63MP0000858_altered_metastatic_potential1.11667378
64MP0003866_abnormal_defecation1.10377736
65MP0009333_abnormal_splenocyte_physiolog1.06650637
66MP0002166_altered_tumor_susceptibility1.05066270
67MP0001851_eye_inflammation1.03467452
68MP0003656_abnormal_erythrocyte_physiolo1.03135254
69MP0002396_abnormal_hematopoietic_system1.03053961
70MP0000604_amyloidosis1.02978347
71MP0000343_altered_response_to1.02432780
72MP0001853_heart_inflammation0.99992791
73MP0000015_abnormal_ear_pigmentation0.98682054
74MP0003448_altered_tumor_morphology0.95719492
75MP0005390_skeleton_phenotype0.81649052
76MP0005167_abnormal_blood-brain_barrier0.80002800
77MP0009763_increased_sensitivity_to0.78204925
78MP0000249_abnormal_blood_vessel0.77300098
79MP0009765_abnormal_xenobiotic_induced0.75820037
80MP0004484_altered_response_of0.73590213
81MP0003011_delayed_dark_adaptation0.73396023
82MP0003698_abnormal_male_reproductive0.72964063
83MP0004808_abnormal_hematopoietic_stem0.69694063
84MP0008874_decreased_physiological_sensi0.69525181
85MP0002138_abnormal_hepatobiliary_system0.67992456
86MP0002006_tumorigenesis0.67744222
87MP0003045_fibrosis0.64087403
88MP0002332_abnormal_exercise_endurance0.63953795
89MP0003329_amyloid_beta_deposits0.62821726
90MP0001663_abnormal_digestive_system0.61659704
91MP0003091_abnormal_cell_migration0.59955595
92MP0003221_abnormal_cardiomyocyte_apopto0.58980238
93MP0005075_abnormal_melanosome_morpholog0.58747382
94MP0001765_abnormal_ion_homeostasis0.58153253
95MP0001929_abnormal_gametogenesis0.57906978
96MP0005376_homeostasis/metabolism_phenot0.57087697
97MP0004130_abnormal_muscle_cell0.56718810
98MP0003795_abnormal_bone_structure0.55798776
99MP0009115_abnormal_fat_cell0.53827853
100MP0005319_abnormal_enzyme/_coenzyme0.53403971

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)6.38809262
2Recurrent abscess formation (HP:0002722)6.26043047
3Eczematoid dermatitis (HP:0000976)6.21752632
4Myositis (HP:0100614)5.79302226
5Orchitis (HP:0100796)5.75468208
6Retrobulbar optic neuritis (HP:0100654)5.66198857
7Optic neuritis (HP:0100653)5.66198857
8Abnormality of macrophages (HP:0004311)5.47956263
9Recurrent gram-negative bacterial infections (HP:0005420)5.08613808
10Stomatitis (HP:0010280)4.66030887
11Gastrointestinal infarctions (HP:0005244)4.55320458
12Elevated erythrocyte sedimentation rate (HP:0003565)4.51867476
13Recurrent skin infections (HP:0001581)4.12789047
14Keratoconjunctivitis sicca (HP:0001097)4.09020349
15Obstructive lung disease (HP:0006536)4.04237253
16Chronic obstructive pulmonary disease (HP:0006510)4.04237253
17Gingivitis (HP:0000230)4.01817210
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.00098698
19Recurrent fungal infections (HP:0002841)3.95761396
20Keratoconjunctivitis (HP:0001096)3.75661779
21Mediastinal lymphadenopathy (HP:0100721)3.71461039
22Peritonitis (HP:0002586)3.64592344
23Meningitis (HP:0001287)3.60371207
24Amyloidosis (HP:0011034)3.47296239
25Recurrent cutaneous fungal infections (HP:0011370)3.39942287
26Chronic mucocutaneous candidiasis (HP:0002728)3.39942287
27Encephalitis (HP:0002383)3.37899396
28Spontaneous hematomas (HP:0007420)3.30062028
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.29837742
30Vasculitis (HP:0002633)3.22132439
31Arterial thrombosis (HP:0004420)3.21828908
32Urticaria (HP:0001025)3.19447753
33Gingival bleeding (HP:0000225)3.19190649
34Chest pain (HP:0100749)3.12396048
35Hemoptysis (HP:0002105)3.09377855
36Episodic fever (HP:0001954)3.06627738
37Prolonged bleeding time (HP:0003010)3.00956645
38Hypochromic microcytic anemia (HP:0004840)2.94315467
39Severe visual impairment (HP:0001141)2.91639427
40Pulmonary infiltrates (HP:0002113)2.90376078
41T lymphocytopenia (HP:0005403)2.85339528
42Increased IgE level (HP:0003212)2.84620733
43Leukocytosis (HP:0001974)2.82079026
44Cellulitis (HP:0100658)2.77215549
45Abnormality of T cell number (HP:0011839)2.74650789
46Epistaxis (HP:0000421)2.61408152
47Anorexia (HP:0002039)2.60848006
48Resting tremor (HP:0002322)2.58272923
49Pulmonary embolism (HP:0002204)2.54277094
50Hypochromic anemia (HP:0001931)2.52419954
51Asymmetric septal hypertrophy (HP:0001670)2.52269559
52Gangrene (HP:0100758)2.50698365
53Abnormality of the peritoneum (HP:0002585)2.41745568
54Abnormality of T cells (HP:0002843)2.39613921
55Nasal polyposis (HP:0100582)2.36451714
56Inflammation of the large intestine (HP:0002037)2.36154903
57Recurrent pneumonia (HP:0006532)2.35933513
58Recurrent viral infections (HP:0004429)2.34459532
59Increased cerebral lipofuscin (HP:0011813)2.30814309
60Vertigo (HP:0002321)2.29871003
61Glomerulopathy (HP:0100820)2.29383467
62Abnormality of liposaccharide metabolism (HP:0010968)2.28774646
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.28774646
64Abnormality of glycolipid metabolism (HP:0010969)2.28774646
65Absent/shortened dynein arms (HP:0200106)2.25315569
66Dynein arm defect of respiratory motile cilia (HP:0012255)2.25315569
67Abnormality of the pleura (HP:0002103)2.22168231
68Osteomyelitis (HP:0002754)2.19231606
69Gastrointestinal inflammation (HP:0004386)2.18187512
70Slow saccadic eye movements (HP:0000514)2.16548921
71Postural instability (HP:0002172)2.14868112
72Abnormality of the endocardium (HP:0004306)2.12899706
73Granulocytopenia (HP:0001913)2.11172690
74Acute hepatic failure (HP:0006554)2.10573611
75Petechiae (HP:0000967)2.08265284
76Abnormality of T cell physiology (HP:0011840)2.06130753
77Acne (HP:0001061)1.99906689
78Sepsis (HP:0100806)1.99019307
79Increased IgM level (HP:0003496)1.95908168
80Abnormality of the nasal mucosa (HP:0000433)1.95745884
81Colitis (HP:0002583)1.95680449
82Loss of speech (HP:0002371)1.95640487
83Polyneuropathy (HP:0001271)1.95424567
84Autoimmune thrombocytopenia (HP:0001973)1.93341206
85Cheilitis (HP:0100825)1.89985302
86Microcytic anemia (HP:0001935)1.89651141
87Hepatosplenomegaly (HP:0001433)1.89246633
88Segmental peripheral demyelination/remyelination (HP:0003481)1.88475609
89Increased neuronal autofluorescent lipopigment (HP:0002074)1.84867327
90Keratitis (HP:0000491)1.83401141
91Eosinophilia (HP:0001880)1.82346236
92Recurrent lower respiratory tract infections (HP:0002783)1.81648046
93Hypoplasia of the thymus (HP:0000778)1.81272418
94Pustule (HP:0200039)1.80505654
95Purpura (HP:0000979)1.77330009
96Amaurosis fugax (HP:0100576)1.76825906
97Increased serum ferritin (HP:0003281)1.76657193
98Myocardial infarction (HP:0001658)1.76334275
99Skin ulcer (HP:0200042)1.74343022
100Hypergammaglobulinemia (HP:0010702)1.73671489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.34588252
2BLK3.55512017
3IRAK43.35807987
4MAP2K32.97043068
5CSK2.73087296
6MAP4K12.65651209
7TYK22.53705348
8FES2.22219589
9GRK62.03496400
10ERN12.02324904
11ZAP701.97643824
12JAK31.87306492
13FGR1.78936276
14TXK1.77913889
15MAP3K31.75815840
16KSR21.75038562
17TNK21.74955964
18EPHB11.73933745
19MAP3K141.70895203
20MAP3K111.67898373
21PIK3CG1.62549034
22SYK1.62338832
23HCK1.55987055
24BTK1.55359622
25JAK21.52050927
26TAOK11.50932453
27PRPF4B1.45146831
28IKBKE1.45005322
29MAP3K11.44978807
30TAOK31.40905013
31MAP3K21.40162932
32IRAK11.37186047
33PLK41.33724574
34LYN1.31452241
35PDK11.31395452
36MAP3K131.29640370
37IRAK21.28837086
38BMPR21.25933084
39PDPK11.24364958
40YES11.22935747
41STK381.17630938
42MATK1.15382383
43JAK11.14060641
44WNK11.10712869
45TBK11.08770156
46CSF1R1.04583643
47DDR21.00298530
48KIT0.99050607
49PTK2B0.98904502
50MARK30.96286999
51MARK20.93193678
52LCK0.92463060
53TEC0.90247915
54IKBKB0.89083283
55ITK0.88375291
56MAP3K60.85199170
57SIK20.82260334
58SIK30.78733238
59DYRK1B0.77327863
60MAP2K40.75597610
61BRD40.70157074
62CDK190.70069503
63TESK10.69247512
64SGK30.68208990
65STK100.68110863
66SGK20.63904165
67GRK70.63102389
68TGFBR20.61201561
69CAMK1G0.61130801
70TESK20.58711194
71PTK60.57682867
72TAOK20.57499007
73MAP3K50.55970203
74FYN0.55349443
75CAMK1D0.55245005
76LRRK20.54688293
77FGFR30.53329008
78STK110.52290627
79RPS6KC10.51819847
80RPS6KL10.51819847
81DAPK20.50135514
82RPS6KA60.47506121
83RAF10.46450827
84EPHA30.46049840
85PRKCQ0.41679971
86INSRR0.41504130
87MAP2K60.41245323
88MAP3K70.40744331
89CAMK40.40018576
90PRKG20.39860806
91MAPK70.39261526
92PRKCZ0.39044377
93MAPK120.39005637
94CAMKK20.38322093
95RET0.38169819
96PLK20.37692154
97ACVR1B0.36702580
98DYRK30.36421621
99KSR10.36156696
100MAPKAPK20.34896995

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.21837507
2Osteoclast differentiation_Homo sapiens_hsa043803.08850372
3Staphylococcus aureus infection_Homo sapiens_hsa051502.79437704
4Tuberculosis_Homo sapiens_hsa051522.34866796
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.24407957
6B cell receptor signaling pathway_Homo sapiens_hsa046622.22466737
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20203144
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.14406654
9Graft-versus-host disease_Homo sapiens_hsa053322.13237418
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06525661
11Allograft rejection_Homo sapiens_hsa053302.05714766
12Legionellosis_Homo sapiens_hsa051341.94609016
13Malaria_Homo sapiens_hsa051441.93690050
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89012742
15Autoimmune thyroid disease_Homo sapiens_hsa053201.88104610
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70964603
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69275935
18Influenza A_Homo sapiens_hsa051641.68160912
19Measles_Homo sapiens_hsa051621.67729431
20Chemokine signaling pathway_Homo sapiens_hsa040621.65005162
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.61054372
22Acute myeloid leukemia_Homo sapiens_hsa052211.60106586
23Antigen processing and presentation_Homo sapiens_hsa046121.59469391
24Type I diabetes mellitus_Homo sapiens_hsa049401.57601506
25Toxoplasmosis_Homo sapiens_hsa051451.57073073
26Hematopoietic cell lineage_Homo sapiens_hsa046401.50022550
27Phagosome_Homo sapiens_hsa041451.49603927
28T cell receptor signaling pathway_Homo sapiens_hsa046601.39970270
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37900019
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.37733713
31TNF signaling pathway_Homo sapiens_hsa046681.30275396
32Viral myocarditis_Homo sapiens_hsa054161.29301653
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28405457
34Primary immunodeficiency_Homo sapiens_hsa053401.23794659
35Non-small cell lung cancer_Homo sapiens_hsa052231.20081319
36Herpes simplex infection_Homo sapiens_hsa051681.18373607
37African trypanosomiasis_Homo sapiens_hsa051431.17998165
38Dorso-ventral axis formation_Homo sapiens_hsa043201.16520205
39Platelet activation_Homo sapiens_hsa046111.13961516
40Hepatitis B_Homo sapiens_hsa051611.13748814
41Pertussis_Homo sapiens_hsa051331.13458116
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.05385852
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.03095308
44Fatty acid biosynthesis_Homo sapiens_hsa000611.01440917
45Other glycan degradation_Homo sapiens_hsa005111.00452362
46Rheumatoid arthritis_Homo sapiens_hsa053230.98633373
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98448594
48Asthma_Homo sapiens_hsa053100.98044787
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97280320
50VEGF signaling pathway_Homo sapiens_hsa043700.95289580
51Salmonella infection_Homo sapiens_hsa051320.95244358
52Lysosome_Homo sapiens_hsa041420.93048128
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93033668
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.91342212
55Prolactin signaling pathway_Homo sapiens_hsa049170.88975612
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88823896
57Endocytosis_Homo sapiens_hsa041440.88635112
58Pancreatic cancer_Homo sapiens_hsa052120.85995046
59Hepatitis C_Homo sapiens_hsa051600.85208187
60Shigellosis_Homo sapiens_hsa051310.84135175
61Apoptosis_Homo sapiens_hsa042100.83609902
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83452856
63Type II diabetes mellitus_Homo sapiens_hsa049300.81282648
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78152835
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.74757192
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.74668796
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.73684902
68Renal cell carcinoma_Homo sapiens_hsa052110.73259634
69Chronic myeloid leukemia_Homo sapiens_hsa052200.72449708
70Notch signaling pathway_Homo sapiens_hsa043300.70443376
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67851693
72FoxO signaling pathway_Homo sapiens_hsa040680.67362938
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64849632
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64486995
75Amoebiasis_Homo sapiens_hsa051460.64407481
76HIF-1 signaling pathway_Homo sapiens_hsa040660.64182468
77Inositol phosphate metabolism_Homo sapiens_hsa005620.62058965
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.60436358
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.58825852
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57560140
81Choline metabolism in cancer_Homo sapiens_hsa052310.55043941
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54745001
83Viral carcinogenesis_Homo sapiens_hsa052030.53948689
84Epstein-Barr virus infection_Homo sapiens_hsa051690.52628783
85Olfactory transduction_Homo sapiens_hsa047400.52490318
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51716498
87MAPK signaling pathway_Homo sapiens_hsa040100.51030442
88Estrogen signaling pathway_Homo sapiens_hsa049150.50395422
89GnRH signaling pathway_Homo sapiens_hsa049120.49674318
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49500096
91Endometrial cancer_Homo sapiens_hsa052130.48793545
92mTOR signaling pathway_Homo sapiens_hsa041500.48713657
93Insulin resistance_Homo sapiens_hsa049310.48083509
94Regulation of autophagy_Homo sapiens_hsa041400.45336403
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44749963
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37147968
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36160265
98ErbB signaling pathway_Homo sapiens_hsa040120.35200784
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34898960
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33907486

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