SIRPG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)7.56528828
2cytidine deamination (GO:0009972)7.56528828
3cytidine metabolic process (GO:0046087)7.56528828
4pyrimidine ribonucleoside catabolic process (GO:0046133)6.93470403
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.65300937
6positive regulation of gamma-delta T cell activation (GO:0046645)6.28668266
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.14102040
8cellular response to interleukin-15 (GO:0071350)5.96989437
9negative T cell selection (GO:0043383)5.90858953
10DNA deamination (GO:0045006)5.88223467
11regulation of B cell receptor signaling pathway (GO:0050855)5.83213560
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.82966933
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.81432054
14negative regulation of cell killing (GO:0031342)5.81432054
15response to interleukin-15 (GO:0070672)5.61331664
16positive thymic T cell selection (GO:0045059)5.50085459
17T cell migration (GO:0072678)5.49084262
18negative thymic T cell selection (GO:0045060)5.47607071
19regulation of regulatory T cell differentiation (GO:0045589)5.45372474
20positive T cell selection (GO:0043368)5.37247137
21regulation of T cell tolerance induction (GO:0002664)5.18196981
22regulation of gamma-delta T cell differentiation (GO:0045586)5.14472591
23thymic T cell selection (GO:0045061)4.98759276
24Arp2/3 complex-mediated actin nucleation (GO:0034314)4.96618371
25positive regulation of tolerance induction (GO:0002645)4.87020158
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.84312150
27regulation of natural killer cell mediated immunity (GO:0002715)4.80337012
28regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.80337012
29regulation of gamma-delta T cell activation (GO:0046643)4.67896807
30T cell selection (GO:0045058)4.65077649
31positive regulation of natural killer cell mediated immunity (GO:0002717)4.62610513
32antigen processing and presentation of endogenous antigen (GO:0019883)4.50809242
33regulation of activation of Janus kinase activity (GO:0010533)4.49619780
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.47835934
35regulation of tolerance induction (GO:0002643)4.41700710
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.36989697
37positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.36280882
38T cell receptor signaling pathway (GO:0050852)4.30400948
39positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.26314924
40negative regulation of T cell apoptotic process (GO:0070233)4.24255223
41actin nucleation (GO:0045010)4.20582321
42regulation of leukocyte mediated cytotoxicity (GO:0001910)4.14802811
43regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.13616541
44regulation of alpha-beta T cell proliferation (GO:0046640)4.05048539
45negative regulation of viral genome replication (GO:0045071)3.90540242
46regulation of interleukin-2 biosynthetic process (GO:0045076)3.89963999
47T cell costimulation (GO:0031295)3.89882321
48leukocyte aggregation (GO:0070486)3.88586358
49regulation of T cell receptor signaling pathway (GO:0050856)3.87704913
50positive regulation of T cell mediated cytotoxicity (GO:0001916)3.86393167
51lymphocyte costimulation (GO:0031294)3.85610070
52antigen receptor-mediated signaling pathway (GO:0050851)3.84623189
53positive regulation of cell killing (GO:0031343)3.84543545
54regulation of chronic inflammatory response (GO:0002676)3.83965842
55positive regulation of B cell differentiation (GO:0045579)3.83110287
56regulation of T cell mediated cytotoxicity (GO:0001914)3.81075732
57regulation of cell killing (GO:0031341)3.76848988
58positive regulation of alpha-beta T cell proliferation (GO:0046641)3.75868118
59positive regulation of calcium-mediated signaling (GO:0050850)3.75548616
60regulation of B cell differentiation (GO:0045577)3.75285497
61tolerance induction (GO:0002507)3.71988161
62lymphocyte chemotaxis (GO:0048247)3.68971286
63negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.67236142
64regulation of isotype switching to IgG isotypes (GO:0048302)3.63377055
65positive regulation of interleukin-4 production (GO:0032753)3.55391530
66dendritic cell chemotaxis (GO:0002407)3.49504637
67negative regulation by host of viral transcription (GO:0043922)3.48106639
68lymphocyte migration (GO:0072676)3.46623338
69positive regulation of interleukin-8 secretion (GO:2000484)3.46114104
70interferon-gamma production (GO:0032609)3.44202290
71mast cell activation (GO:0045576)3.41050127
72negative regulation of leukocyte mediated immunity (GO:0002704)3.38822435
73activated T cell proliferation (GO:0050798)3.36359458
74negative regulation of lymphocyte mediated immunity (GO:0002707)3.36288359
75regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.35616639
76pyrimidine nucleoside catabolic process (GO:0046135)3.34934884
77negative regulation of T cell mediated immunity (GO:0002710)3.31970107
78antigen processing and presentation via MHC class Ib (GO:0002475)3.27436905
79positive regulation of granulocyte differentiation (GO:0030854)3.27042445
80regulation of lymphocyte chemotaxis (GO:1901623)3.26883592
81regulation of T cell apoptotic process (GO:0070232)3.26418781
82eosinophil chemotaxis (GO:0048245)3.22314511
83immunoglobulin mediated immune response (GO:0016064)3.22196381
84cellular response to type I interferon (GO:0071357)3.17561709
85type I interferon signaling pathway (GO:0060337)3.17561709
86positive regulation of T cell chemotaxis (GO:0010820)3.16999902
87regulation of T cell chemotaxis (GO:0010819)3.16999902
88regulation of defense response to virus by virus (GO:0050690)3.16733543
89granulocyte activation (GO:0036230)3.14344250
90response to type I interferon (GO:0034340)3.13807597
91dendritic cell migration (GO:0036336)3.12100648
92cellular defense response (GO:0006968)3.11098297
93leukocyte degranulation (GO:0043299)3.09798285
94positive regulation of T cell mediated immunity (GO:0002711)3.07321233
95positive regulation of lymphocyte mediated immunity (GO:0002708)3.06721498
96negative regulation of lymphocyte apoptotic process (GO:0070229)3.05057362
97positive regulation of T cell apoptotic process (GO:0070234)3.04240427
98chemokine-mediated signaling pathway (GO:0070098)3.02139915
99positive regulation of defense response to virus by host (GO:0002230)3.01902870
100macrophage chemotaxis (GO:0048246)2.99327656

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.14517972
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.03257414
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.45360546
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.21209595
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.71283274
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.85210467
7RUNX_20019798_ChIP-Seq_JUKART_Human3.67830434
8MYB_26560356_Chip-Seq_TH2_Human3.66997202
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.60098737
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.56502555
11STAT4_19710469_ChIP-ChIP_TH1__Mouse3.14961584
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.13476155
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.93212878
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91140910
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.91030906
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.87215587
17MYB_26560356_Chip-Seq_TH1_Human2.72332887
18* UTX_26944678_Chip-Seq_JUKART_Human2.70336112
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.68096314
20MAF_26560356_Chip-Seq_TH1_Human2.66697512
21* GATA3_27048872_Chip-Seq_THYMUS_Human2.50090004
22MAF_26560356_Chip-Seq_TH2_Human2.39457033
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18768836
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.10022048
25* SPI1_23547873_ChIP-Seq_NB4_Human2.06570513
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.05070730
27* GATA3_26560356_Chip-Seq_TH2_Human1.97519697
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.94558326
29LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.92234130
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.90614996
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89877581
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77990083
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75149768
34MYC_22102868_ChIP-Seq_BL_Human1.74894262
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.72986026
36CIITA_25753668_ChIP-Seq_RAJI_Human1.61302587
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58460137
38LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57898333
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.55020167
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52381562
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.50834369
42SPI1_23127762_ChIP-Seq_K562_Human1.48726634
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.45525321
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40261911
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37390349
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.36788818
47GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35704685
48SCL_19346495_ChIP-Seq_HPC-7_Human1.35673133
49VDR_24763502_ChIP-Seq_THP-1_Human1.35661880
50BCL6_27268052_Chip-Seq_Bcells_Human1.34744452
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25987533
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25926833
53VDR_23849224_ChIP-Seq_CD4+_Human1.22157030
54VDR_21846776_ChIP-Seq_THP-1_Human1.15582588
55FOXP3_21729870_ChIP-Seq_TREG_Human1.14682701
56SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10385954
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05876163
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01706173
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00464509
60BCOR_27268052_Chip-Seq_Bcells_Human0.98034618
61* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97168431
62CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95488215
63P300_27268052_Chip-Seq_Bcells_Human0.95185074
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94954852
65RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94887681
66* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93210621
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92928926
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90903088
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90528957
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89726259
71PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87965274
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87960708
73KDM2B_26808549_Chip-Seq_DND41_Human0.87486392
74SA1_27219007_Chip-Seq_Bcells_Human0.86447929
75* GATA3_26560356_Chip-Seq_TH1_Human0.85455220
76TCF7_22412390_ChIP-Seq_EML_Mouse0.84586055
77* ELF1_20517297_ChIP-Seq_JURKAT_Human0.82524272
78HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82333705
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.81052960
80SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80019563
81RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79838018
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78592511
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77533405
84GABP_17652178_ChIP-ChIP_JURKAT_Human0.76806762
85SPI1_20517297_ChIP-Seq_HL60_Human0.75848603
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.75701429
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74567135
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.73669252
89GATA1_19941827_ChIP-Seq_MEL_Mouse0.72394176
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71236555
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.70454094
92CTCF_20526341_ChIP-Seq_ESCs_Human0.70361950
93ELK3_25401928_ChIP-Seq_HUVEC_Human0.70202612
94NANOG_20526341_ChIP-Seq_ESCs_Human0.67562568
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.66255746
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.66248837
97TAF2_19829295_ChIP-Seq_ESCs_Human0.65257260
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64616159
99RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64507916
100KDM2B_26808549_Chip-Seq_SUP-B15_Human0.64424926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.48673087
2MP0003763_abnormal_thymus_physiology4.67370356
3MP0001835_abnormal_antigen_presentation3.65415976
4MP0009785_altered_susceptibility_to3.41617495
5MP0005000_abnormal_immune_tolerance3.36063936
6MP0001800_abnormal_humoral_immune3.31486223
7MP0003436_decreased_susceptibility_to3.26937924
8MP0009333_abnormal_splenocyte_physiolog3.08829335
9MP0005387_immune_system_phenotype3.01474928
10MP0001790_abnormal_immune_system3.01474928
11MP0005025_abnormal_response_to2.95800143
12MP0002723_abnormal_immune_serum2.90578568
13MP0002420_abnormal_adaptive_immunity2.90203780
14MP0001873_stomach_inflammation2.86119335
15MP0001819_abnormal_immune_cell2.83957560
16MP0000685_abnormal_immune_system2.80409466
17MP0006082_CNS_inflammation2.78744523
18MP0003724_increased_susceptibility_to2.61866500
19MP0002148_abnormal_hypersensitivity_rea2.60816074
20MP0002452_abnormal_antigen_presenting2.55695062
21MP0003866_abnormal_defecation2.49546854
22MP0002405_respiratory_system_inflammati2.39688357
23MP0002398_abnormal_bone_marrow2.39351585
24MP0010155_abnormal_intestine_physiology2.31255546
25MP0002419_abnormal_innate_immunity2.30495630
26MP0000703_abnormal_thymus_morphology2.27825423
27MP0000716_abnormal_immune_system2.27091057
28MP0002166_altered_tumor_susceptibility2.15825496
29MP0002722_abnormal_immune_system1.98973780
30MP0000689_abnormal_spleen_morphology1.93879461
31MP0001845_abnormal_inflammatory_respons1.86074803
32MP0004947_skin_inflammation1.84984038
33MP0005464_abnormal_platelet_physiology1.81291984
34MP0002933_joint_inflammation1.77666605
35MP0002429_abnormal_blood_cell1.76219841
36MP0003045_fibrosis1.64103647
37MP0001533_abnormal_skeleton_physiology1.57857523
38MP0002006_tumorigenesis1.56919700
39MP0003300_gastrointestinal_ulcer1.51100017
40MP0002277_abnormal_respiratory_mucosa1.46555073
41MP0003448_altered_tumor_morphology1.38948719
42MP0004381_abnormal_hair_follicle1.37590737
43MP0008469_abnormal_protein_level1.29023519
44MP0005310_abnormal_salivary_gland1.24461152
45MP0005075_abnormal_melanosome_morpholog1.19277792
46MP0000465_gastrointestinal_hemorrhage1.19169515
47MP0002138_abnormal_hepatobiliary_system1.16987646
48MP0001853_heart_inflammation1.14349058
49MP0009764_decreased_sensitivity_to1.05535552
50MP0000858_altered_metastatic_potential1.02615342
51MP0009763_increased_sensitivity_to1.02581208
52MP0005451_abnormal_body_composition0.92808332
53MP0003303_peritoneal_inflammation0.91954938
54MP0003183_abnormal_peptide_metabolism0.87266232
55MP0005166_decreased_susceptibility_to0.85753708
56MP0001986_abnormal_taste_sensitivity0.85182475
57MP0002019_abnormal_tumor_incidence0.84426079
58MP0002009_preneoplasia0.84386340
59MP0000490_abnormal_crypts_of0.84107505
60MP0002163_abnormal_gland_morphology0.83787377
61MP0005377_hearing/vestibular/ear_phenot0.82017008
62MP0003878_abnormal_ear_physiology0.82017008
63MP0002396_abnormal_hematopoietic_system0.81435438
64MP0002132_abnormal_respiratory_system0.80802791
65MP0002998_abnormal_bone_remodeling0.80455820
66MP0001348_abnormal_lacrimal_gland0.76262075
67MP0003786_premature_aging0.73827081
68MP0003075_altered_response_to0.73489328
69MP0005645_abnormal_hypothalamus_physiol0.71532809
70MP0001663_abnormal_digestive_system0.71246179
71MP0002693_abnormal_pancreas_physiology0.69558995
72MP0003806_abnormal_nucleotide_metabolis0.67679389
73MP0009765_abnormal_xenobiotic_induced0.64866613
74MP0001851_eye_inflammation0.61609260
75MP0008961_abnormal_basal_metabolism0.59007901
76MP0001919_abnormal_reproductive_system0.57273896
77MP0005390_skeleton_phenotype0.56853463
78MP0005379_endocrine/exocrine_gland_phen0.56509403
79MP0000015_abnormal_ear_pigmentation0.55725928
80MP0003252_abnormal_bile_duct0.55699990
81MP0008873_increased_physiological_sensi0.55334903
82MP0002136_abnormal_kidney_physiology0.51258582
83MP0001905_abnormal_dopamine_level0.51166469
84MP0001765_abnormal_ion_homeostasis0.50665239
85MP0000604_amyloidosis0.50171080
86MP0003646_muscle_fatigue0.50126078
87MP0003795_abnormal_bone_structure0.49730872
88MP0004883_abnormal_blood_vessel0.47864245
89MP0002877_abnormal_melanocyte_morpholog0.47179446
90MP0008260_abnormal_autophagy0.46684621
91MP0003172_abnormal_lysosome_physiology0.46556597
92MP0009643_abnormal_urine_homeostasis0.44730759
93MP0000920_abnormal_myelination0.43565277
94MP0002168_other_aberrant_phenotype0.41839615
95MP0008872_abnormal_physiological_respon0.41240967
96MP0004145_abnormal_muscle_electrophysio0.41228894
97MP0004130_abnormal_muscle_cell0.41219143
98MP0000249_abnormal_blood_vessel0.38202857
99MP0004510_myositis0.37990758
100MP0000569_abnormal_digit_pigmentation0.37484336

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.26710556
2Abnormality of T cell number (HP:0011839)7.07829938
3Autoimmune hemolytic anemia (HP:0001890)6.06008838
4Elevated erythrocyte sedimentation rate (HP:0003565)5.62023807
5Stomatitis (HP:0010280)5.51590813
6Increased IgM level (HP:0003496)5.36957795
7Severe combined immunodeficiency (HP:0004430)5.27143248
8Abnormality of T cells (HP:0002843)5.21439827
9Abnormal delayed hypersensitivity skin test (HP:0002963)5.04806337
10IgG deficiency (HP:0004315)4.83122156
11Myositis (HP:0100614)4.52032838
12Combined immunodeficiency (HP:0005387)4.26158098
13Encephalitis (HP:0002383)4.04349717
14Abnormality of macrophages (HP:0004311)4.00478009
15Abnormality of eosinophils (HP:0001879)3.98196159
16Meningitis (HP:0001287)3.96612879
17Recurrent abscess formation (HP:0002722)3.96525448
18Aplastic anemia (HP:0001915)3.91253075
19Pustule (HP:0200039)3.83431890
20Chronic obstructive pulmonary disease (HP:0006510)3.80853025
21Obstructive lung disease (HP:0006536)3.80853025
22Eczematoid dermatitis (HP:0000976)3.77743473
23Recurrent bacterial skin infections (HP:0005406)3.75663501
24Gastrointestinal infarctions (HP:0005244)3.74489880
25Recurrent cutaneous fungal infections (HP:0011370)3.74401016
26Chronic mucocutaneous candidiasis (HP:0002728)3.74401016
27Recurrent fungal infections (HP:0002841)3.65531833
28Recurrent bronchitis (HP:0002837)3.61585501
29Chronic diarrhea (HP:0002028)3.60595644
30Abnormality of T cell physiology (HP:0011840)3.57238992
31Leukocytosis (HP:0001974)3.52836235
32Vasculitis (HP:0002633)3.51073518
33Lymphopenia (HP:0001888)3.50560283
34Abnormality of B cell number (HP:0010975)3.50282354
35Granulocytopenia (HP:0001913)3.48757867
36Abnormality of cells of the lymphoid lineage (HP:0012140)3.47458151
37Orchitis (HP:0100796)3.45550351
38Retrobulbar optic neuritis (HP:0100654)3.44105899
39Optic neuritis (HP:0100653)3.44105899
40Eosinophilia (HP:0001880)3.43270889
41Thyroiditis (HP:0100646)3.42669703
42Panhypogammaglobulinemia (HP:0003139)3.40071712
43Mediastinal lymphadenopathy (HP:0100721)3.36770809
44Autoimmune thrombocytopenia (HP:0001973)3.29103489
45Pulmonary infiltrates (HP:0002113)3.26885566
46Recurrent viral infections (HP:0004429)3.26049923
47Hypergammaglobulinemia (HP:0010702)3.17428008
48Chest pain (HP:0100749)3.13258850
49IgM deficiency (HP:0002850)3.13023325
50Recurrent skin infections (HP:0001581)3.10140468
51Hypoproteinemia (HP:0003075)3.08248294
52Hypoplasia of the thymus (HP:0000778)3.02699830
53Abnormality of the prostate (HP:0008775)2.97716918
54Agammaglobulinemia (HP:0004432)2.95538033
55B lymphocytopenia (HP:0010976)2.87836501
56Acute hepatic failure (HP:0006554)2.84053000
57Hemoptysis (HP:0002105)2.76649851
58Joint swelling (HP:0001386)2.72962210
59Lymphoma (HP:0002665)2.59423910
60Gangrene (HP:0100758)2.58650662
61Increased IgE level (HP:0003212)2.54601177
62Keratoconjunctivitis sicca (HP:0001097)2.49435333
63Pulmonary embolism (HP:0002204)2.47474718
64Hypochromic anemia (HP:0001931)2.47382751
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.45931504
66Abnormality of the pleura (HP:0002103)2.32648614
67Keratoconjunctivitis (HP:0001096)2.31038397
68Spontaneous hematomas (HP:0007420)2.30038975
69Urticaria (HP:0001025)2.29732580
70Bronchitis (HP:0012387)2.23130461
71Recurrent gram-negative bacterial infections (HP:0005420)2.22729694
72Inflammation of the large intestine (HP:0002037)2.22390805
73Epistaxis (HP:0000421)2.13383067
74Arterial thrombosis (HP:0004420)2.12038107
75Skin rash (HP:0000988)2.12019863
76Anorexia (HP:0002039)2.11745552
77Gastrointestinal inflammation (HP:0004386)2.06198051
78Gingivitis (HP:0000230)2.03468795
79Hemiplegia (HP:0002301)2.02464803
80Amyotrophic lateral sclerosis (HP:0007354)2.00035184
81Glomerulopathy (HP:0100820)1.98564691
82Aplasia/Hypoplasia of the thymus (HP:0010515)1.95632884
83Recurrent otitis media (HP:0000403)1.94727854
84Pulmonary fibrosis (HP:0002206)1.93817393
85Ureteral stenosis (HP:0000071)1.93573566
86Episodic fever (HP:0001954)1.92185455
87Recurrent sinusitis (HP:0011108)1.91903183
88Petechiae (HP:0000967)1.90926679
89Verrucae (HP:0200043)1.87464470
90Papilloma (HP:0012740)1.87464470
91Amaurosis fugax (HP:0100576)1.83053907
92Keratitis (HP:0000491)1.82555220
933-Methylglutaconic aciduria (HP:0003535)1.80790056
94Polyneuropathy (HP:0001271)1.80357046
95Gingival bleeding (HP:0000225)1.78774889
96Ureteral obstruction (HP:0006000)1.78089637
97Microcytic anemia (HP:0001935)1.78054418
98Stomach cancer (HP:0012126)1.77101658
99Prolonged bleeding time (HP:0003010)1.76795068
100Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76718321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.24743114
2MAP4K14.72089713
3KDR4.49381227
4TESK23.72411233
5FES2.71787166
6ITK2.64939311
7ZAP702.62498300
8RIPK42.53003425
9CSK2.37144206
10GRK62.30209634
11BTK2.07080441
12MAP3K111.95694658
13SYK1.94664722
14TAOK31.86805624
15LCK1.85963620
16IKBKE1.69131578
17JAK31.65300015
18TYK21.63914596
19TBK11.61723100
20TEC1.50453157
21BLK1.50143574
22PRKCQ1.49623126
23TNK21.47323013
24MST41.41693461
25TESK11.40315255
26MAP3K121.35050829
27LYN1.33684816
28JAK11.32875223
29CLK11.30053229
30MAP3K141.29064480
31IRAK41.29050136
32IKBKB1.26500244
33MAP4K21.25894385
34HCK1.19716646
35BMPR21.10611399
36GRK71.08792446
37CSF1R1.05383493
38TLK10.99507892
39PASK0.99352892
40ZAK0.98698187
41ADRBK20.94370738
42LIMK10.93539044
43SIK30.84840006
44ERN10.84484170
45JAK20.82551047
46FYN0.82039812
47STK100.80846256
48SCYL20.73883123
49TYRO30.73237751
50PIK3CG0.72128260
51PRPF4B0.71784335
52MARK30.70586531
53BCKDK0.70451322
54CAMKK10.69349514
55CAMKK20.67927723
56TAOK20.63939404
57PIM10.63058121
58TAOK10.60097592
59VRK20.58355147
60FGR0.57542046
61NLK0.53903497
62MAPKAPK30.51080616
63LRRK20.50799492
64PRKCH0.50314953
65PDGFRB0.46356928
66CDK40.46164890
67PTK60.45156152
68EPHB10.44541211
69MAP2K30.43707861
70MAP3K30.43369702
71MAP3K130.42395296
72IGF1R0.41554009
73DAPK10.40157067
74KIT0.39342644
75FGFR40.39075661
76SIK20.39027092
77MAPK110.38670320
78PDK10.38205257
79INSR0.36513812
80MAPKAPK20.33908070
81PIK3CA0.33888676
82MAP3K50.32000420
83VRK10.30927027
84MAP3K10.30681617
85HIPK20.30178949
86MAP3K70.29435007
87MAPK120.28044164
88RPS6KA50.27624924
89CHUK0.21542185
90BUB10.20754425
91MAP2K60.20319343
92SMG10.20138695
93ROCK10.19855446
94MYLK0.19642585
95EGFR0.19201098
96NUAK10.18839670
97ABL10.18246957
98PRKCD0.17575636
99MAPK30.16472272
100MUSK0.16368574

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.23920428
2Graft-versus-host disease_Homo sapiens_hsa053324.46468444
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.56588398
4T cell receptor signaling pathway_Homo sapiens_hsa046603.55714466
5Autoimmune thyroid disease_Homo sapiens_hsa053203.54661346
6Antigen processing and presentation_Homo sapiens_hsa046123.53632768
7Allograft rejection_Homo sapiens_hsa053303.44999223
8Hematopoietic cell lineage_Homo sapiens_hsa046402.84977150
9Type I diabetes mellitus_Homo sapiens_hsa049402.56160261
10Measles_Homo sapiens_hsa051622.34907810
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27360114
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.25752389
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15154960
14Proteasome_Homo sapiens_hsa030501.99396133
15Viral myocarditis_Homo sapiens_hsa054161.88360471
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.81376057
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73598250
18Rheumatoid arthritis_Homo sapiens_hsa053231.60705291
19Leishmaniasis_Homo sapiens_hsa051401.58278435
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54925922
21* Osteoclast differentiation_Homo sapiens_hsa043801.53703118
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50919104
23Chemokine signaling pathway_Homo sapiens_hsa040621.50860282
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49851411
25Shigellosis_Homo sapiens_hsa051311.49086402
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46244256
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45691752
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.44016557
29Asthma_Homo sapiens_hsa053101.41929984
30Staphylococcus aureus infection_Homo sapiens_hsa051501.36752758
31Malaria_Homo sapiens_hsa051441.35876702
32Herpes simplex infection_Homo sapiens_hsa051681.34952073
33B cell receptor signaling pathway_Homo sapiens_hsa046621.22426445
34Salmonella infection_Homo sapiens_hsa051321.20040598
35TNF signaling pathway_Homo sapiens_hsa046681.11252763
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.09946557
37Tuberculosis_Homo sapiens_hsa051520.93758828
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92500734
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90490970
40Influenza A_Homo sapiens_hsa051640.88908901
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88060638
42Apoptosis_Homo sapiens_hsa042100.86886904
43Epstein-Barr virus infection_Homo sapiens_hsa051690.85861731
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82692850
45Legionellosis_Homo sapiens_hsa051340.81019539
46HTLV-I infection_Homo sapiens_hsa051660.76375833
47Toxoplasmosis_Homo sapiens_hsa051450.73904640
48Oxidative phosphorylation_Homo sapiens_hsa001900.73209292
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.70239016
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67806361
51African trypanosomiasis_Homo sapiens_hsa051430.67758435
52Parkinsons disease_Homo sapiens_hsa050120.65964379
53Pertussis_Homo sapiens_hsa051330.57582174
54Endocytosis_Homo sapiens_hsa041440.57169129
55Viral carcinogenesis_Homo sapiens_hsa052030.55782372
56Platelet activation_Homo sapiens_hsa046110.55270347
57Regulation of autophagy_Homo sapiens_hsa041400.52658278
58Hepatitis B_Homo sapiens_hsa051610.48876624
59Acute myeloid leukemia_Homo sapiens_hsa052210.45878125
60Non-small cell lung cancer_Homo sapiens_hsa052230.43463733
61Phagosome_Homo sapiens_hsa041450.42658364
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39824636
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39225132
64Ribosome_Homo sapiens_hsa030100.37535207
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36488061
66Hepatitis C_Homo sapiens_hsa051600.36142432
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34371188
68Alzheimers disease_Homo sapiens_hsa050100.34029333
69Pancreatic cancer_Homo sapiens_hsa052120.31271864
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28278998
71Systemic lupus erythematosus_Homo sapiens_hsa053220.28097308
72RNA polymerase_Homo sapiens_hsa030200.27719059
73VEGF signaling pathway_Homo sapiens_hsa043700.27440452
74Prion diseases_Homo sapiens_hsa050200.27196546
75Linoleic acid metabolism_Homo sapiens_hsa005910.19135821
76MAPK signaling pathway_Homo sapiens_hsa040100.17649051
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.16486899
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13971798
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.13144901
80Ras signaling pathway_Homo sapiens_hsa040140.12334710
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.11117886
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10642274
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.08410323
84Peroxisome_Homo sapiens_hsa041460.07154632
85Lysosome_Homo sapiens_hsa041420.06457821
86Rap1 signaling pathway_Homo sapiens_hsa040150.06456543
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.06217229
88Huntingtons disease_Homo sapiens_hsa050160.05222662
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.04568717
90Chronic myeloid leukemia_Homo sapiens_hsa052200.04038695
91Insulin resistance_Homo sapiens_hsa049310.02696411
92Caffeine metabolism_Homo sapiens_hsa002320.02554617
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.02533454
94Phototransduction_Homo sapiens_hsa047440.02166257
95Olfactory transduction_Homo sapiens_hsa047400.01239413
96Arachidonic acid metabolism_Homo sapiens_hsa005900.01080282
97Colorectal cancer_Homo sapiens_hsa052100.00425213
98Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0113621
99Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0097527
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.0093792

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