SIRT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.50360081
2nuclear pore complex assembly (GO:0051292)4.64633914
3nuclear pore organization (GO:0006999)4.53692269
4mitotic metaphase plate congression (GO:0007080)4.40477416
5meiotic chromosome segregation (GO:0045132)4.39951684
6protein complex localization (GO:0031503)4.24960806
7DNA unwinding involved in DNA replication (GO:0006268)4.11946801
8metaphase plate congression (GO:0051310)4.10765329
9cellular protein complex localization (GO:0034629)4.03625188
10heterochromatin organization (GO:0070828)4.01205834
11positive regulation of SMAD protein import into nucleus (GO:0060391)3.86627274
12histone H3-K36 demethylation (GO:0070544)3.83249880
13protein K6-linked ubiquitination (GO:0085020)3.82428133
14DNA replication checkpoint (GO:0000076)3.80985289
15kinetochore organization (GO:0051383)3.79874686
16positive regulation of mitotic sister chromatid separation (GO:1901970)3.76714876
17positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.76714876
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.76714876
19maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.74961132
20positive regulation of chromosome segregation (GO:0051984)3.64924632
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.63307164
22regulation of translation, ncRNA-mediated (GO:0045974)3.63307164
23negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.63307164
24kinetochore assembly (GO:0051382)3.61704531
25negative regulation of fibroblast apoptotic process (GO:2000270)3.54180107
26pore complex assembly (GO:0046931)3.50999208
27negative regulation of DNA-dependent DNA replication (GO:2000104)3.48640968
28DNA double-strand break processing (GO:0000729)3.46514188
29mitotic sister chromatid cohesion (GO:0007064)3.43907339
30establishment of integrated proviral latency (GO:0075713)3.42887618
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42401947
32chromatin remodeling at centromere (GO:0031055)3.41857679
33regulation of nuclear cell cycle DNA replication (GO:0033262)3.38184178
34establishment of chromosome localization (GO:0051303)3.36230778
35protein localization to kinetochore (GO:0034501)3.36036011
36regulation of double-strand break repair via homologous recombination (GO:0010569)3.34622542
37DNA replication initiation (GO:0006270)3.33010152
38regulation of nucleobase-containing compound transport (GO:0032239)3.32229253
39CENP-A containing nucleosome assembly (GO:0034080)3.32070362
40mitotic nuclear envelope disassembly (GO:0007077)3.31721048
41negative regulation of DNA repair (GO:0045738)3.30988257
42regulation of gene silencing by RNA (GO:0060966)3.29253893
43regulation of posttranscriptional gene silencing (GO:0060147)3.29253893
44regulation of gene silencing by miRNA (GO:0060964)3.29253893
45negative regulation of mRNA metabolic process (GO:1903312)3.29218173
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.27302724
47regulation of DNA endoreduplication (GO:0032875)3.27289734
48replication fork processing (GO:0031297)3.26864722
49NLS-bearing protein import into nucleus (GO:0006607)3.24469913
50regulation of RNA export from nucleus (GO:0046831)3.23158691
51mitotic G2/M transition checkpoint (GO:0044818)3.21425011
52attachment of spindle microtubules to kinetochore (GO:0008608)3.21003205
53regulation of DNA methylation (GO:0044030)3.20927069
54somatic hypermutation of immunoglobulin genes (GO:0016446)3.20624830
55somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20624830
56* DNA synthesis involved in DNA repair (GO:0000731)3.19662474
57regulation of spindle organization (GO:0090224)3.18488727
58negative regulation of mRNA processing (GO:0050686)3.17080392
59regulation of telomere maintenance via telomerase (GO:0032210)3.16105517
60mRNA stabilization (GO:0048255)3.13657269
61RNA stabilization (GO:0043489)3.13657269
62negative regulation of chromosome segregation (GO:0051985)3.10380359
63DNA strand renaturation (GO:0000733)3.10126266
64negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09874502
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.09874502
66negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09874502
67negative regulation of mitotic sister chromatid separation (GO:2000816)3.09874502
68negative regulation of sister chromatid segregation (GO:0033046)3.09874502
69* regulation of helicase activity (GO:0051095)3.09651777
70mitotic chromosome condensation (GO:0007076)3.08871442
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08796972
72embryonic process involved in female pregnancy (GO:0060136)3.07352037
73N-terminal protein amino acid acetylation (GO:0006474)3.05425389
74membrane disassembly (GO:0030397)3.04167877
75nuclear envelope disassembly (GO:0051081)3.04167877
76positive regulation of catenin import into nucleus (GO:0035413)3.03671230
77protein localization to chromosome, centromeric region (GO:0071459)3.03139660
78double-strand break repair via nonhomologous end joining (GO:0006303)3.02838149
79non-recombinational repair (GO:0000726)3.02838149
80DNA replication-independent nucleosome organization (GO:0034724)3.01571307
81DNA replication-independent nucleosome assembly (GO:0006336)3.01571307
82negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99902725
83DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.99815056
84histone H4-K12 acetylation (GO:0043983)2.99046287
85histone exchange (GO:0043486)2.98630594
86* regulation of histone H3-K9 methylation (GO:0051570)2.97557140
87DNA topological change (GO:0006265)2.97150010
88trophectodermal cell differentiation (GO:0001829)2.95982770
89mitotic G2 DNA damage checkpoint (GO:0007095)2.94665875
90positive regulation of histone H3-K4 methylation (GO:0051571)2.92609433
91regulation of sister chromatid cohesion (GO:0007063)2.92577167
92mitotic sister chromatid segregation (GO:0000070)2.91690364
93reciprocal meiotic recombination (GO:0007131)2.89908390
94reciprocal DNA recombination (GO:0035825)2.89908390
95nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.88514729
96inner cell mass cell proliferation (GO:0001833)2.87890398
97regulation of double-strand break repair (GO:2000779)2.87341786
98interferon-gamma secretion (GO:0072643)2.86043466
99mitotic spindle checkpoint (GO:0071174)2.85820483
100mismatch repair (GO:0006298)2.85802560
101DNA replication-dependent nucleosome organization (GO:0034723)2.84544073
102DNA replication-dependent nucleosome assembly (GO:0006335)2.84544073
103monoubiquitinated protein deubiquitination (GO:0035520)2.84279285
104microtubule depolymerization (GO:0007019)2.83899875
105regulation of centrosome cycle (GO:0046605)2.83702774
106ribosome assembly (GO:0042255)2.83609775
107* positive regulation of histone methylation (GO:0031062)2.83248189
108resolution of meiotic recombination intermediates (GO:0000712)2.83173403
109DNA damage response, signal transduction resulting in transcription (GO:0042772)2.82550358
110* regulation of histone methylation (GO:0031060)2.82166706
111regulation of chromatin binding (GO:0035561)2.81921975
112histone lysine demethylation (GO:0070076)2.80759214
113sister chromatid cohesion (GO:0007062)2.80424025
114regulation of mitotic spindle organization (GO:0060236)2.79944348
115regulation of chromosome segregation (GO:0051983)2.77574371
116regulation of centrosome duplication (GO:0010824)2.76809976
117notochord development (GO:0030903)2.76641950
118regulation of histone H3-K27 methylation (GO:0061085)2.76433783
119regulation of meiosis I (GO:0060631)2.75949553
120mitotic spindle assembly checkpoint (GO:0007094)2.75715401
121histone demethylation (GO:0016577)2.75517352
122chromosome segregation (GO:0007059)2.74773817
123ribosome biogenesis (GO:0042254)2.74005288
124negative regulation of histone methylation (GO:0031061)2.73509248
125purine nucleobase biosynthetic process (GO:0009113)2.72018067
126oogenesis (GO:0048477)2.71953504
127spindle checkpoint (GO:0031577)2.71899757
128spindle assembly checkpoint (GO:0071173)2.68805873
129sister chromatid segregation (GO:0000819)2.68432358
130negative regulation of RNA splicing (GO:0033119)2.68230064
131regulation of transcription from RNA polymerase I promoter (GO:0006356)2.67675694
132regulation of mitotic metaphase/anaphase transition (GO:0030071)2.66469880
133regulation of mRNA stability (GO:0043488)2.66389569
134paraxial mesoderm development (GO:0048339)2.66190069
135DNA conformation change (GO:0071103)2.64984002
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63912628
137protein localization to chromosome (GO:0034502)2.63076384
138intra-S DNA damage checkpoint (GO:0031573)2.61715816
139telomere maintenance via recombination (GO:0000722)2.61080429
140regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.60587418
141DNA geometric change (GO:0032392)2.60143426
142DNA duplex unwinding (GO:0032508)2.58412660
143mitotic recombination (GO:0006312)2.58033901
144regulation of centriole replication (GO:0046599)2.57513795
145dosage compensation (GO:0007549)2.56364644
146histone H2A monoubiquitination (GO:0035518)2.56081949
147ATP-dependent chromatin remodeling (GO:0043044)2.56024974
148nucleobase biosynthetic process (GO:0046112)2.55498441
149regulation of mitotic sister chromatid separation (GO:0010965)2.55293427
150regulation of mitotic sister chromatid segregation (GO:0033047)2.55293427
151regulation of sister chromatid segregation (GO:0033045)2.55293427
152histone H3-K9 methylation (GO:0051567)2.54275826
153chromosome organization involved in meiosis (GO:0070192)2.53844555
154meiotic cell cycle process (GO:1903046)2.53578975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.88436768
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.62513706
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16430079
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.98667511
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40383580
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.13550187
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.13550187
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.13550187
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.97888628
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.82366655
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.81852990
12* MYC_18555785_ChIP-Seq_MESCs_Mouse2.77199255
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63374366
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55963850
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47056328
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44142740
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.34155241
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.27415770
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.17770384
20* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.15549984
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14754064
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10681812
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.04193224
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96040745
25AR_21909140_ChIP-Seq_LNCAP_Human1.94079704
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.85785149
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84932493
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.83202514
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82659151
30SOX2_18555785_ChIP-Seq_MESCs_Mouse1.74770158
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73885962
32* VDR_23849224_ChIP-Seq_CD4+_Human1.67410221
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66441827
34WT1_19549856_ChIP-ChIP_CCG9911_Human1.62543134
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61185704
36* NOTCH1_21737748_ChIP-Seq_TLL_Human1.60133520
37NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.59600543
38TCF3_18692474_ChIP-Seq_MESCs_Mouse1.59420974
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55002446
40ELK1_19687146_ChIP-ChIP_HELA_Human1.54815657
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47119654
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46805216
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44689123
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43906820
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43182730
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.40691619
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40379959
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36393013
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.34016353
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33523322
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.33101949
52NANOG_16153702_ChIP-ChIP_HESCs_Human1.32756505
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32129995
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.30796035
55* XRN2_22483619_ChIP-Seq_HELA_Human1.26889127
56KDM5A_27292631_Chip-Seq_BREAST_Human1.25947876
57* TFEB_21752829_ChIP-Seq_HELA_Human1.25019095
58NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.24883135
59* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24782545
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.23208899
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23168478
62* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21928897
63MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21080713
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20704680
65* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20302640
66SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.20211743
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20198685
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19437060
69* CHD1_26751641_Chip-Seq_LNCaP_Human1.18824039
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.17444513
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.16885626
72CLOCK_20551151_ChIP-Seq_293T_Human1.15901588
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15371238
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14637198
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14351726
76* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13029135
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12586434
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12312066
79* TTF2_22483619_ChIP-Seq_HELA_Human1.12203782
80* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11334254
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10190281
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.08132374
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08090833
84NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06554027
85KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05928668
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05233107
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04678663
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03760855
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01113999
90FOXP3_21729870_ChIP-Seq_TREG_Human1.00893555
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00689698
92PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99929630
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.98722552
94DCP1A_22483619_ChIP-Seq_HELA_Human0.97576409
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97342203
96* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.93506011
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.92255085
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92050838
99* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91987081
100FOXO3_23340844_ChIP-Seq_DLD1_Human0.91290013
101TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.90875728
102MYB_26560356_Chip-Seq_TH2_Human0.90409670
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90000433
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88422385
105MYB_26560356_Chip-Seq_TH1_Human0.86639954
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.86588620
107POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86296138
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86232262
109PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85295529
110SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84816376
111NANOG_21062744_ChIP-ChIP_HESCs_Human0.84584152
112* PU_27001747_Chip-Seq_BMDM_Mouse0.84361243
113SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84191422
114EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84064551
115* KAP1_27257070_Chip-Seq_ESCs_Mouse0.84022738
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84008081
117* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82776640
118* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82698804
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82387941
120* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.81858339
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.80598450
122* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79851170
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79173062
124TCF7_22412390_ChIP-Seq_EML_Mouse0.78708554
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.78202801
126* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.78039622
127GATA1_22025678_ChIP-Seq_K562_Human0.77504363
128* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77138759
129* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77099312
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76993876
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76595692
132CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.76301407
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75727261
134FUS_26573619_Chip-Seq_HEK293_Human0.75574639
135EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.75317131
136EWS_26573619_Chip-Seq_HEK293_Human0.75062306
137STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.74975267
138NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74077351
139CIITA_25753668_ChIP-Seq_RAJI_Human0.74076098
140SUZ12_27294783_Chip-Seq_NPCs_Mouse0.73282502
141MYC_22102868_ChIP-Seq_BL_Human0.71864169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.29475371
2* MP0008057_abnormal_DNA_replication3.90912281
3MP0003693_abnormal_embryo_hatching3.76561792
4MP0010094_abnormal_chromosome_stability3.58452149
5* MP0003111_abnormal_nucleus_morphology3.33471419
6* MP0003077_abnormal_cell_cycle2.94991510
7* MP0008058_abnormal_DNA_repair2.78160351
8MP0010234_abnormal_vibrissa_follicle2.74482074
9MP0004957_abnormal_blastocyst_morpholog2.72977795
10MP0008007_abnormal_cellular_replicative2.41484122
11MP0009672_abnormal_birth_weight2.38054704
12MP0001346_abnormal_lacrimal_gland2.30442655
13MP0008877_abnormal_DNA_methylation2.27357344
14MP0004185_abnormal_adipocyte_glucose2.05087770
15MP0003941_abnormal_skin_development2.02356546
16MP0003786_premature_aging2.00744973
17MP0002277_abnormal_respiratory_mucosa2.00435297
18MP0003221_abnormal_cardiomyocyte_apopto1.92869864
19MP0010307_abnormal_tumor_latency1.92584649
20MP0002009_preneoplasia1.91205462
21MP0004808_abnormal_hematopoietic_stem1.86628902
22MP0003890_abnormal_embryonic-extraembry1.75381514
23MP0000350_abnormal_cell_proliferation1.71566925
24MP0006292_abnormal_olfactory_placode1.70702076
25MP0000383_abnormal_hair_follicle1.68868317
26MP0010352_gastrointestinal_tract_polyps1.68342204
27MP0008932_abnormal_embryonic_tissue1.65463295
28MP0000566_synostosis1.64433394
29MP0009703_decreased_birth_body1.62439628
30MP0000537_abnormal_urethra_morphology1.60533681
31MP0003136_yellow_coat_color1.55683335
32MP0005076_abnormal_cell_differentiation1.55008527
33MP0002396_abnormal_hematopoietic_system1.52651295
34MP0000685_abnormal_immune_system1.50741868
35* MP0002210_abnormal_sex_determination1.49269199
36MP0003718_maternal_effect1.47389994
37MP0008995_early_reproductive_senescence1.43182594
38MP0003763_abnormal_thymus_physiology1.39913935
39MP0001730_embryonic_growth_arrest1.38871368
40MP0003705_abnormal_hypodermis_morpholog1.37468477
41MP0005380_embryogenesis_phenotype1.36752679
42MP0001672_abnormal_embryogenesis/_devel1.36752679
43MP0004233_abnormal_muscle_weight1.34064196
44MP0002166_altered_tumor_susceptibility1.33146546
45MP0001873_stomach_inflammation1.30455867
46MP0010678_abnormal_skin_adnexa1.30330897
47MP0003453_abnormal_keratinocyte_physiol1.29914467
48MP0001348_abnormal_lacrimal_gland1.23309323
49* MP0002085_abnormal_embryonic_tissue1.22259144
50MP0005310_abnormal_salivary_gland1.21415045
51MP0001188_hyperpigmentation1.20205940
52MP0002084_abnormal_developmental_patter1.19322314
53* MP0001929_abnormal_gametogenesis1.19140523
54MP0009697_abnormal_copulation1.18504535
55* MP0001145_abnormal_male_reproductive1.17260795
56MP0009333_abnormal_splenocyte_physiolog1.16632243
57MP0004197_abnormal_fetal_growth/weight/1.15666677
58MP0000428_abnormal_craniofacial_morphol1.14338237
59* MP0002697_abnormal_eye_size1.14231312
60* MP0005647_abnormal_sex_gland1.14203884
61MP0002086_abnormal_extraembryonic_tissu1.13910098
62MP0000613_abnormal_salivary_gland1.11251971
63* MP0001697_abnormal_embryo_size1.09654360
64MP0002160_abnormal_reproductive_system1.08946410
65* MP0001119_abnormal_female_reproductive1.06241829
66* MP0003937_abnormal_limbs/digits/tail_de1.06202086
67MP0001835_abnormal_antigen_presentation1.05655385
68MP0003984_embryonic_growth_retardation1.04991152
69* MP0000653_abnormal_sex_gland1.04606720
70MP0003567_abnormal_fetal_cardiomyocyte1.03635507
71MP0003123_paternal_imprinting1.03571555
72MP0002088_abnormal_embryonic_growth/wei1.03104356
73MP0002876_abnormal_thyroid_physiology1.02974107
74MP0000490_abnormal_crypts_of1.00325195
75MP0002098_abnormal_vibrissa_morphology0.99615530
76MP0003315_abnormal_perineum_morphology0.98590324
77MP0001293_anophthalmia0.97633759
78MP0003943_abnormal_hepatobiliary_system0.97284489
79MP0000470_abnormal_stomach_morphology0.96922853
80MP0005389_reproductive_system_phenotype0.96905315
81MP0002132_abnormal_respiratory_system0.95167440
82MP0003566_abnormal_cell_adhesion0.94687671
83* MP0005621_abnormal_cell_physiology0.94417696
84MP0005666_abnormal_adipose_tissue0.93887379
85MP0010030_abnormal_orbit_morphology0.91761452
86MP0003115_abnormal_respiratory_system0.90288031
87* MP0000313_abnormal_cell_death0.89395244
88* MP0002019_abnormal_tumor_incidence0.89095198
89* MP0001286_abnormal_eye_development0.88118935
90MP0002163_abnormal_gland_morphology0.87493519
91MP0003121_genomic_imprinting0.86944847
92MP0001485_abnormal_pinna_reflex0.86938331
93MP0004264_abnormal_extraembryonic_tissu0.86492809
94MP0000703_abnormal_thymus_morphology0.85917634
95MP0002877_abnormal_melanocyte_morpholog0.85785951
96MP0010630_abnormal_cardiac_muscle0.85548424
97MP0003755_abnormal_palate_morphology0.85356286
98* MP0002925_abnormal_cardiovascular_devel0.85115693
99MP0002111_abnormal_tail_morphology0.84770548
100MP0001915_intracranial_hemorrhage0.84539597
101MP0000516_abnormal_urinary_system0.84132262
102MP0005367_renal/urinary_system_phenotyp0.84132262
103MP0003091_abnormal_cell_migration0.84082426
104* MP0002080_prenatal_lethality0.83522365
105MP0003656_abnormal_erythrocyte_physiolo0.82112498
106MP0002398_abnormal_bone_marrow0.81589690
107MP0006082_CNS_inflammation0.80074666
108MP0003119_abnormal_digestive_system0.79490904
109* MP0005384_cellular_phenotype0.79488526
110MP0001216_abnormal_epidermal_layer0.78719923
111MP0002796_impaired_skin_barrier0.78098260
112MP0003787_abnormal_imprinting0.77618798
113MP0003935_abnormal_craniofacial_develop0.74927367
114MP0004381_abnormal_hair_follicle0.74452488
115MP0005501_abnormal_skin_physiology0.74258428
116MP0001299_abnormal_eye_distance/0.73339422
117MP0001851_eye_inflammation0.73225237
118MP0002006_tumorigenesis0.72865596
119MP0002653_abnormal_ependyma_morphology0.72677817
120MP0005671_abnormal_response_to0.72563026
121MP0001853_heart_inflammation0.71446680
122* MP0003936_abnormal_reproductive_system0.70371418
123MP0003950_abnormal_plasma_membrane0.70052887
124MP0009278_abnormal_bone_marrow0.69999808
125* MP0000432_abnormal_head_morphology0.69258059
126* MP0001784_abnormal_fluid_regulation0.69052148
127* MP0002405_respiratory_system_inflammati0.68759357
128* MP0001800_abnormal_humoral_immune0.68645668
129MP0000762_abnormal_tongue_morphology0.68217307
130MP0001545_abnormal_hematopoietic_system0.67973705
131MP0005397_hematopoietic_system_phenotyp0.67973705
132MP0009053_abnormal_anal_canal0.66510949
133MP0005375_adipose_tissue_phenotype0.64425931
134MP0001177_atelectasis0.62828292
135MP0006035_abnormal_mitochondrial_morpho0.62611383
136MP0000689_abnormal_spleen_morphology0.62565771
137* MP0002092_abnormal_eye_morphology0.62508251
138* MP0003861_abnormal_nervous_system0.61396110
139MP0001727_abnormal_embryo_implantation0.60842381
140MP0005187_abnormal_penis_morphology0.60697474
141MP0002722_abnormal_immune_system0.60190274

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.49706614
2Chromsome breakage (HP:0040012)5.41486798
3Birth length less than 3rd percentile (HP:0003561)3.59495900
4Abnormality of the preputium (HP:0100587)3.54216360
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.52876187
6Duplicated collecting system (HP:0000081)3.40937555
7Ectopic kidney (HP:0000086)3.34353117
8Abnormality of chromosome stability (HP:0003220)3.32131528
9Deep philtrum (HP:0002002)3.29481659
10Meckel diverticulum (HP:0002245)3.27521129
11Prostate neoplasm (HP:0100787)3.26532069
12Lip pit (HP:0100267)3.21579356
13Malignant gastrointestinal tract tumors (HP:0006749)3.20908238
14Gastrointestinal carcinoma (HP:0002672)3.20908238
15Abnormality of the ileum (HP:0001549)3.19294928
16Subacute progressive viral hepatitis (HP:0006572)3.15168288
17Abnormality of the renal collecting system (HP:0004742)3.10199923
18Breast hypoplasia (HP:0003187)3.09947755
19Asplenia (HP:0001746)3.09727992
20Abnormal hair whorl (HP:0010721)3.03593530
21Absent radius (HP:0003974)3.01744514
22Transitional cell carcinoma of the bladder (HP:0006740)3.00277623
23Aplasia/Hypoplasia of the spleen (HP:0010451)2.94302536
24Impulsivity (HP:0100710)2.90101735
25Abnormality of the labia minora (HP:0012880)2.87647410
26Aplasia involving forearm bones (HP:0009822)2.82766773
27Absent forearm bone (HP:0003953)2.82766773
28Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.82732713
29Uterine leiomyosarcoma (HP:0002891)2.81826478
30Leiomyosarcoma (HP:0100243)2.81826478
31Bladder neoplasm (HP:0009725)2.76862415
32Bladder carcinoma (HP:0002862)2.76862415
33Breast carcinoma (HP:0003002)2.65821267
34Medulloblastoma (HP:0002885)2.64060438
35Neoplasm of the adrenal cortex (HP:0100641)2.63957319
36Neonatal hypoglycemia (HP:0001998)2.60937579
37Patellar aplasia (HP:0006443)2.57350509
38Small intestinal stenosis (HP:0012848)2.50354249
39Duodenal stenosis (HP:0100867)2.50354249
40Aqueductal stenosis (HP:0002410)2.49341483
41Clubbing of toes (HP:0100760)2.47047500
42Supernumerary spleens (HP:0009799)2.46465409
43Abnormality of the fingertips (HP:0001211)2.46111866
44Aplasia/Hypoplasia of the patella (HP:0006498)2.42466772
45Hepatoblastoma (HP:0002884)2.41373003
46Recurrent cutaneous fungal infections (HP:0011370)2.36067135
47Chronic mucocutaneous candidiasis (HP:0002728)2.36067135
48Uterine neoplasm (HP:0010784)2.36007478
49Ependymoma (HP:0002888)2.35013040
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.34318438
51Septo-optic dysplasia (HP:0100842)2.32583472
52Spastic diplegia (HP:0001264)2.32062602
53Keratoconjunctivitis (HP:0001096)2.32052166
54Volvulus (HP:0002580)2.29898186
55Curly hair (HP:0002212)2.29548361
56Embryonal neoplasm (HP:0002898)2.28903869
57Absent thumb (HP:0009777)2.28212476
58Abnormality of DNA repair (HP:0003254)2.27682674
59Reticulocytopenia (HP:0001896)2.26460307
60Absent eyebrow (HP:0002223)2.23798535
61Myelodysplasia (HP:0002863)2.22590090
62Azoospermia (HP:0000027)2.21103070
63Abnormality of the left ventricular outflow tract (HP:0011103)2.20800191
64Subaortic stenosis (HP:0001682)2.20800191
65Squamous cell carcinoma (HP:0002860)2.17594435
66Short thumb (HP:0009778)2.16660297
67Abnormality of chromosome segregation (HP:0002916)2.16358030
68Abnormal spermatogenesis (HP:0008669)2.09517679
69Progressive external ophthalmoplegia (HP:0000590)2.09308632
70Increased nuchal translucency (HP:0010880)2.08974825
71Ureteral duplication (HP:0000073)2.08111933
72Abnormal lung lobation (HP:0002101)2.07857502
73Rhabdomyosarcoma (HP:0002859)2.06344174
74T lymphocytopenia (HP:0005403)2.05744185
75Neoplasm of the small intestine (HP:0100833)2.05236115
76Nephroblastoma (Wilms tumor) (HP:0002667)2.03824661
77Neoplasm of striated muscle (HP:0009728)2.03302326
78Cystic hygroma (HP:0000476)2.03294487
79Tracheoesophageal fistula (HP:0002575)2.02805691
80Agnosia (HP:0010524)2.02489459
81Sparse lateral eyebrow (HP:0005338)1.99468148
82Anal stenosis (HP:0002025)1.98792316
83Abnormality of the duodenum (HP:0002246)1.97408357
84Capillary hemangiomas (HP:0005306)1.97243086
85Pelvic girdle muscle weakness (HP:0003749)1.96616002
86Abnormality of the carotid arteries (HP:0005344)1.96542335
87Type 2 muscle fiber atrophy (HP:0003554)1.95337745
88Neoplasm of the oral cavity (HP:0100649)1.94684281
89Renal cell carcinoma (HP:0005584)1.94164621
90Heterotopia (HP:0002282)1.93870879
91Colon cancer (HP:0003003)1.91966057
92Cafe-au-lait spot (HP:0000957)1.91814363
93Bone marrow hypocellularity (HP:0005528)1.91521571
94Selective tooth agenesis (HP:0001592)1.90687804
95Facial hemangioma (HP:0000329)1.90269459
96Absent hand (HP:0004050)1.90211012
97Embryonal renal neoplasm (HP:0011794)1.89745501
98Broad thumb (HP:0011304)1.88736915
99Stomach cancer (HP:0012126)1.88680628
100Sloping forehead (HP:0000340)1.87554546
101Muscle fiber atrophy (HP:0100295)1.85836199
102Narrow palate (HP:0000189)1.84928211
103Upper limb muscle weakness (HP:0003484)1.84486336
104Viral hepatitis (HP:0006562)1.83193359
105Short middle phalanx of the 5th finger (HP:0004220)1.82756145
106Stenosis of the external auditory canal (HP:0000402)1.82692889
107Diastasis recti (HP:0001540)1.82603350
108Prominent nose (HP:0000448)1.82419289
109Dysmetric saccades (HP:0000641)1.82175134
110Neoplasm of the colon (HP:0100273)1.81724696
111Abnormality of the septum pellucidum (HP:0007375)1.81424400
112Tongue fasciculations (HP:0001308)1.81174888
113Breast aplasia (HP:0100783)1.80199791
114Cortical dysplasia (HP:0002539)1.80194926
115Rib fusion (HP:0000902)1.80017660
116Pustule (HP:0200039)1.79353046
117Obsessive-compulsive behavior (HP:0000722)1.78826291
118Relative macrocephaly (HP:0004482)1.78824645
119Abnormality of male internal genitalia (HP:0000022)1.78441480
120Triphalangeal thumb (HP:0001199)1.78202867
121Overgrowth (HP:0001548)1.77829062
122Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77710627
123Basal cell carcinoma (HP:0002671)1.77390737
124Syringomyelia (HP:0003396)1.76640690
125Spinal cord lesions (HP:0100561)1.76640690
126High anterior hairline (HP:0009890)1.76331847
127Glioma (HP:0009733)1.75964980
128Abnormality of cochlea (HP:0000375)1.75365363
129Duplication of thumb phalanx (HP:0009942)1.74274913
130Absent septum pellucidum (HP:0001331)1.74109405
131Sex reversal (HP:0012245)1.73106144
132Abnormal sex determination (HP:0012244)1.73106144
133Abnormality of the nasal septum (HP:0000419)1.72399850
134Pancreatic islet-cell hyperplasia (HP:0004510)1.72291182
135Ovarian neoplasm (HP:0100615)1.71282382
136Sandal gap (HP:0001852)1.70830652
137Abnormality of the hepatic vasculature (HP:0006707)1.70659122
138Adactyly (HP:0009776)1.69449599
139Acute lymphatic leukemia (HP:0006721)1.69424285
140Skull defect (HP:0001362)1.69299775
141Termporal pattern (HP:0011008)1.69242674
142Insidious onset (HP:0003587)1.69242674
143Choanal stenosis (HP:0000452)1.69115788
144Amaurosis fugax (HP:0100576)1.68961624
145Missing ribs (HP:0000921)1.68866153
146Short hallux (HP:0010109)1.68771441
147Aplasia/hypoplasia of the humerus (HP:0006507)1.68596138
148Biliary tract neoplasm (HP:0100574)1.68477967
149Abnormality of the phalanges of the 5th finger (HP:0004213)1.68447451
150Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67077292
151Esophageal atresia (HP:0002032)1.66986520
152Acute myeloid leukemia (HP:0004808)1.66954434
153Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66651831
154Wide nose (HP:0000445)1.66504764
155Deep palmar crease (HP:0006191)1.66468737
156Carpal bone hypoplasia (HP:0001498)1.66388003
157Aplasia/Hypoplasia of the hallux (HP:0008362)1.66271967
158Abnormality of the hip-girdle musculature (HP:0001445)1.66096992
159Abnormality of the musculature of the pelvis (HP:0001469)1.66096992
160Germ cell neoplasia (HP:0100728)1.66089380
161Deviation of the thumb (HP:0009603)1.65650591
162Abnormality of the parietal bone (HP:0002696)1.65447103
163Astrocytoma (HP:0009592)1.65265523
164Abnormality of the astrocytes (HP:0100707)1.65265523
165Papillary thyroid carcinoma (HP:0002895)1.64752183
166Abnormality of the columella (HP:0009929)1.64556377
167Aplasia/Hypoplasia of the breasts (HP:0010311)1.63889763
168Leukopenia (HP:0001882)1.63395272
169Recurrent fungal infections (HP:0002841)1.63346650
170Oligodactyly (hands) (HP:0001180)1.63039890
171Intestinal fistula (HP:0100819)1.62835562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.46437538
2CDC73.15486711
3TAF13.13559602
4WEE13.02808019
5SRPK13.02639594
6IRAK32.73843799
7NEK22.55239875
8EPHA22.53752089
9TTK2.41203204
10MKNK22.24594161
11MAP3K142.13680877
12PLK42.13596442
13LATS12.10745336
14TNIK2.09186202
15SMG12.08676762
16ZAK2.06652233
17BRD41.99933791
18STK38L1.97682226
19BUB11.95365045
20PLK11.87757565
21MKNK11.85897264
22IRAK41.82498273
23CHEK21.79452023
24CDK71.79375837
25TSSK61.77324461
26EEF2K1.72356824
27STK31.72240104
28PLK31.64490097
29MAP3K91.62809457
30ATR1.58603025
31ACVR1B1.56360473
32TLK11.53451307
33TRIM281.52826900
34AKT31.49127674
35BRSK21.45434273
36VRK11.43849204
37AURKB1.41398077
38MST41.36240629
39CHEK11.33832253
40ATM1.33698532
41PBK1.28080073
42CAMK1D1.25239371
43CHUK1.22367346
44PRPF4B1.21197200
45EIF2AK21.19386689
46CAMK1G1.17258738
47PIM11.16524778
48MAP3K61.14974638
49STK41.14830565
50DMPK1.12280433
51IKBKB1.11450428
52CDK41.11430738
53RPS6KB21.09934498
54SCYL21.09888417
55MELK1.07044782
56YES11.05023486
57STK101.04613565
58FGFR21.02826877
59EIF2AK11.00056516
60NLK0.98944200
61LATS20.96445715
62BRAF0.95611906
63CDK20.91260573
64EPHA30.90736906
65MARK30.85664620
66RPS6KA40.85562338
67PNCK0.84372953
68CASK0.83281884
69IRAK10.82991119
70CDK90.82978273
71RPS6KA50.82915615
72CDK80.82059585
73CDK30.81456371
74CDK60.81266224
75GRK10.79185726
76WNK10.77394483
77SGK20.77327861
78FGFR10.77151875
79KSR10.72726635
80* CDK10.72260206
81SGK30.72098880
82NEK60.71829266
83BMPR20.71445585
84BMPR1B0.71186488
85SIK30.69532610
86DYRK20.69097667
87TXK0.68821194
88RAF10.64548481
89ERBB30.64210972
90BCR0.62829637
91AURKA0.62429095
92EIF2AK30.62046833
93MAP3K80.60460137
94PRKCI0.60065331
95ALK0.59568265
96NUAK10.58707347
97PRKDC0.56038187
98TYK20.55058883
99TEC0.54354751
100JAK30.53881224
101STK240.53447233
102MAP3K20.53383829
103FGR0.53254773
104TGFBR10.52996658
105ERBB40.52603269
106CLK10.50378013
107MAPK150.50292217
108EPHB10.49652202
109CDK190.49340988
110MTOR0.48743212
111* DYRK30.48321230
112FGFR30.48272258
113DYRK1B0.47825678
114* MAPK140.45585974
115CSNK1D0.44545021
116CSNK2A20.44192425
117MAPK70.44125255
118KSR20.43787209
119PDK20.43363149
120IRAK20.42891947
121* CSNK2A10.42739070
122PDGFRB0.42345805
123EGFR0.39375878
124AKT10.39142003
125TRPM70.38396927
126* GSK3B0.38370633
127MAPK10.37262735
128MAP3K100.37049158
129PASK0.36560005
130CSNK1E0.34788792
131BRSK10.34305151
132MAPK100.33378976
133MAP3K130.33329688
134BMX0.32614913
135RIPK10.32284731
136RPS6KA10.29298584

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.62530451
2Mismatch repair_Homo sapiens_hsa034303.27435383
3Fanconi anemia pathway_Homo sapiens_hsa034603.08321874
4DNA replication_Homo sapiens_hsa030302.94063177
5Homologous recombination_Homo sapiens_hsa034402.85232661
6RNA transport_Homo sapiens_hsa030132.70931057
7RNA polymerase_Homo sapiens_hsa030202.69316658
8Cell cycle_Homo sapiens_hsa041102.63587112
9Spliceosome_Homo sapiens_hsa030402.49762335
10Thyroid cancer_Homo sapiens_hsa052162.36748448
11Basal transcription factors_Homo sapiens_hsa030222.35973799
12mRNA surveillance pathway_Homo sapiens_hsa030152.12955844
13Base excision repair_Homo sapiens_hsa034102.09894180
14Nucleotide excision repair_Homo sapiens_hsa034202.08175035
15p53 signaling pathway_Homo sapiens_hsa041152.07678647
16RNA degradation_Homo sapiens_hsa030181.91056814
17Chronic myeloid leukemia_Homo sapiens_hsa052201.74795170
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.74551085
19Endometrial cancer_Homo sapiens_hsa052131.72992820
20Non-homologous end-joining_Homo sapiens_hsa034501.72915602
21One carbon pool by folate_Homo sapiens_hsa006701.62453110
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.55742226
23Herpes simplex infection_Homo sapiens_hsa051681.52271109
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48737577
25Primary immunodeficiency_Homo sapiens_hsa053401.48465040
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47690429
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47481386
28Pyrimidine metabolism_Homo sapiens_hsa002401.41194677
29Antigen processing and presentation_Homo sapiens_hsa046121.38914102
30Renal cell carcinoma_Homo sapiens_hsa052111.38530839
31Vitamin B6 metabolism_Homo sapiens_hsa007501.30268336
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.29752190
33Non-small cell lung cancer_Homo sapiens_hsa052231.25246544
34Systemic lupus erythematosus_Homo sapiens_hsa053221.24908896
35Epstein-Barr virus infection_Homo sapiens_hsa051691.22914525
36Acute myeloid leukemia_Homo sapiens_hsa052211.17723523
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16017705
38* MicroRNAs in cancer_Homo sapiens_hsa052061.15962115
39Viral carcinogenesis_Homo sapiens_hsa052031.09167685
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07733972
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06140288
42Ribosome_Homo sapiens_hsa030101.06108035
43Basal cell carcinoma_Homo sapiens_hsa052171.04474017
44* Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03532820
45Linoleic acid metabolism_Homo sapiens_hsa005911.02072049
46Proteoglycans in cancer_Homo sapiens_hsa052050.99951683
47Small cell lung cancer_Homo sapiens_hsa052220.98536542
48HTLV-I infection_Homo sapiens_hsa051660.96533496
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.95902291
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94288433
51TGF-beta signaling pathway_Homo sapiens_hsa043500.93310112
52* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92328927
53Measles_Homo sapiens_hsa051620.90718225
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90288858
55Allograft rejection_Homo sapiens_hsa053300.89791315
56Hippo signaling pathway_Homo sapiens_hsa043900.88942553
57Autoimmune thyroid disease_Homo sapiens_hsa053200.88853621
58Graft-versus-host disease_Homo sapiens_hsa053320.85899394
59ErbB signaling pathway_Homo sapiens_hsa040120.85244584
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84560516
61Proteasome_Homo sapiens_hsa030500.84125355
62Adherens junction_Homo sapiens_hsa045200.81581668
63Bladder cancer_Homo sapiens_hsa052190.80538182
64Purine metabolism_Homo sapiens_hsa002300.79754671
65Arachidonic acid metabolism_Homo sapiens_hsa005900.79428506
66Influenza A_Homo sapiens_hsa051640.77505287
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.77503109
68mTOR signaling pathway_Homo sapiens_hsa041500.77415328
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76759827
70Prolactin signaling pathway_Homo sapiens_hsa049170.76209359
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73244071
72Notch signaling pathway_Homo sapiens_hsa043300.72088055
73Apoptosis_Homo sapiens_hsa042100.71405472
74Prostate cancer_Homo sapiens_hsa052150.69793816
75Vitamin digestion and absorption_Homo sapiens_hsa049770.69330804
76Hedgehog signaling pathway_Homo sapiens_hsa043400.67615307
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67545019
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.66723173
79Asthma_Homo sapiens_hsa053100.65457452
80Ether lipid metabolism_Homo sapiens_hsa005650.64414440
81Oocyte meiosis_Homo sapiens_hsa041140.63542567
82Glioma_Homo sapiens_hsa052140.62975149
83Choline metabolism in cancer_Homo sapiens_hsa052310.61945820
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61561876
85Leishmaniasis_Homo sapiens_hsa051400.61467852
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.60649353
87TNF signaling pathway_Homo sapiens_hsa046680.60326428
88MAPK signaling pathway_Homo sapiens_hsa040100.60201174
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59040592
90Pathways in cancer_Homo sapiens_hsa052000.58524484
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.58176159
92Hepatitis B_Homo sapiens_hsa051610.57660952
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57210604
94Legionellosis_Homo sapiens_hsa051340.56983098
95Insulin signaling pathway_Homo sapiens_hsa049100.56967879
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56236907
97Sphingolipid metabolism_Homo sapiens_hsa006000.55831526
98Wnt signaling pathway_Homo sapiens_hsa043100.55714341
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55390552
100Hematopoietic cell lineage_Homo sapiens_hsa046400.54834254
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52137266
102Shigellosis_Homo sapiens_hsa051310.51092092
103HIF-1 signaling pathway_Homo sapiens_hsa040660.50431484
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50057086
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49994575
106Estrogen signaling pathway_Homo sapiens_hsa049150.48936493
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46579231
108African trypanosomiasis_Homo sapiens_hsa051430.46031164
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45712054
110Inositol phosphate metabolism_Homo sapiens_hsa005620.44749624
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.43908861
112Colorectal cancer_Homo sapiens_hsa052100.41408348
113* FoxO signaling pathway_Homo sapiens_hsa040680.41055486
114Toxoplasmosis_Homo sapiens_hsa051450.40086514
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39810809
116Osteoclast differentiation_Homo sapiens_hsa043800.39679587
117Circadian rhythm_Homo sapiens_hsa047100.39013650
118Lysine degradation_Homo sapiens_hsa003100.38150579
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37949618
120T cell receptor signaling pathway_Homo sapiens_hsa046600.37236615
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35044421
122Selenocompound metabolism_Homo sapiens_hsa004500.34703400
123Tight junction_Homo sapiens_hsa045300.33565600
124Phototransduction_Homo sapiens_hsa047440.32442616
125Dorso-ventral axis formation_Homo sapiens_hsa043200.31506703
126B cell receptor signaling pathway_Homo sapiens_hsa046620.31304304
127Hepatitis C_Homo sapiens_hsa051600.31011761
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.29931280
129Regulation of autophagy_Homo sapiens_hsa041400.28812933
130Viral myocarditis_Homo sapiens_hsa054160.28200780
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27303694
132Melanoma_Homo sapiens_hsa052180.27046092
133Pancreatic cancer_Homo sapiens_hsa052120.26654958
134Histidine metabolism_Homo sapiens_hsa003400.26249288

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