SIRT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.47504906
2axon ensheathment in central nervous system (GO:0032291)9.47504906
3fatty acid elongation (GO:0030497)7.16252064
4* ensheathment of neurons (GO:0007272)6.75619427
5* axon ensheathment (GO:0008366)6.75619427
6* myelination (GO:0042552)6.74785649
7long-chain fatty acid biosynthetic process (GO:0042759)5.56133748
8L-amino acid import (GO:0043092)5.09461048
9cholesterol biosynthetic process (GO:0006695)5.08458455
10negative regulation of neurotransmitter secretion (GO:0046929)5.03173633
11activated T cell proliferation (GO:0050798)4.94704599
12regulation of collateral sprouting (GO:0048670)4.84973243
13oligodendrocyte differentiation (GO:0048709)4.77242726
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.71425815
15amino acid import (GO:0043090)4.60330714
16adhesion of symbiont to host cell (GO:0044650)4.53436133
17virion attachment to host cell (GO:0019062)4.53436133
18synaptic vesicle maturation (GO:0016188)4.45523087
19sterol biosynthetic process (GO:0016126)4.40850957
20creatine metabolic process (GO:0006600)4.34346856
21glycerophospholipid catabolic process (GO:0046475)4.31732143
22sarcoplasmic reticulum calcium ion transport (GO:0070296)4.30605341
23postsynaptic membrane organization (GO:0001941)4.21997383
24* substantia nigra development (GO:0021762)4.16105183
25response to methylmercury (GO:0051597)4.14618833
26myelin maintenance (GO:0043217)4.06188955
27negative regulation of neurotransmitter transport (GO:0051589)4.05745325
28presynaptic membrane assembly (GO:0097105)4.02763846
29eye photoreceptor cell differentiation (GO:0001754)4.00891812
30photoreceptor cell differentiation (GO:0046530)4.00891812
31neuron cell-cell adhesion (GO:0007158)3.97447930
32peptidyl-tyrosine autophosphorylation (GO:0038083)3.92456163
33transmission of nerve impulse (GO:0019226)3.91916489
34astrocyte development (GO:0014002)3.91586888
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.84972204
36synaptic vesicle exocytosis (GO:0016079)3.83072148
37muscle filament sliding (GO:0030049)3.81779950
38actin-myosin filament sliding (GO:0033275)3.81779950
39presynaptic membrane organization (GO:0097090)3.77592859
40isoprenoid biosynthetic process (GO:0008299)3.77263283
41negative regulation of axonogenesis (GO:0050771)3.69713010
42import into cell (GO:0098657)3.69614716
43regulation of synapse structural plasticity (GO:0051823)3.66666878
44long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.65485938
45negative regulation of axon extension (GO:0030517)3.65026159
46negative regulation of protein localization to cell surface (GO:2000009)3.58906272
47positive regulation of actin filament depolymerization (GO:0030836)3.54944120
48asymmetric protein localization (GO:0008105)3.51842010
49neuronal ion channel clustering (GO:0045161)3.50087378
50glutamate secretion (GO:0014047)3.44021490
51adhesion of symbiont to host (GO:0044406)3.42186230
52regulation of synaptic vesicle exocytosis (GO:2000300)3.41600918
53regulation of skeletal muscle contraction (GO:0014819)3.41437506
54locomotory exploration behavior (GO:0035641)3.39502126
55regulation of short-term neuronal synaptic plasticity (GO:0048172)3.38994563
56long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.36294064
57neuromuscular synaptic transmission (GO:0007274)3.33366868
58cellular potassium ion homeostasis (GO:0030007)3.28973461
59positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.26974183
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26465158
61apical protein localization (GO:0045176)3.23312099
62Rap protein signal transduction (GO:0032486)3.22821838
63protein palmitoylation (GO:0018345)3.21252527
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.20782773
65fatty-acyl-CoA biosynthetic process (GO:0046949)3.20356641
66skeletal muscle contraction (GO:0003009)3.19437639
67regulation of synaptic vesicle transport (GO:1902803)3.19379360
68amyloid precursor protein metabolic process (GO:0042982)3.17289573
69potassium ion import (GO:0010107)3.15853723
70positive regulation of action potential (GO:0045760)3.15778738
71regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.15501826
72peripheral nervous system development (GO:0007422)3.14265286
73regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.14139750
74response to lipoprotein particle (GO:0055094)3.13714923
75positive regulation of neurological system process (GO:0031646)3.11363077
76nucleotide transmembrane transport (GO:1901679)3.09444356
77positive regulation of oligodendrocyte differentiation (GO:0048714)3.05949696
78membrane depolarization during action potential (GO:0086010)3.03790323
79regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01974904
80fatty-acyl-CoA metabolic process (GO:0035337)2.98582674
81adult walking behavior (GO:0007628)2.98413144
82ionotropic glutamate receptor signaling pathway (GO:0035235)2.96809307
83establishment of mitochondrion localization (GO:0051654)2.96795216
84very long-chain fatty acid metabolic process (GO:0000038)2.95526077
85regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.95502646
86cerebral cortex radially oriented cell migration (GO:0021799)2.95129077
87positive regulation of synapse maturation (GO:0090129)2.95119436
88synaptic transmission, glutamatergic (GO:0035249)2.93612584
89striated muscle contraction (GO:0006941)2.92982276
90sodium ion export (GO:0071436)2.92706903
91neurotransmitter secretion (GO:0007269)2.91077144
92actin-mediated cell contraction (GO:0070252)2.88692179
93cerebellar granule cell differentiation (GO:0021707)2.86786113
94response to inactivity (GO:0014854)2.85233471
95cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85073528
96limb bud formation (GO:0060174)2.84763686
97leukocyte migration involved in inflammatory response (GO:0002523)2.84738844
98vocalization behavior (GO:0071625)2.84433342
99regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.83353129
100neurotransmitter-gated ion channel clustering (GO:0072578)2.82046693
101glycosylceramide metabolic process (GO:0006677)2.80668760
102positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.79762319
103regulation of cell communication by electrical coupling (GO:0010649)2.78297283
104membrane tubulation (GO:0097320)2.77183455
105glial cell development (GO:0021782)2.74979397
106gamma-aminobutyric acid transport (GO:0015812)2.74871784
107positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.74801578
108neurotransmitter catabolic process (GO:0042135)2.73388312
109dendritic spine morphogenesis (GO:0060997)2.73267560
110semaphorin-plexin signaling pathway (GO:0071526)2.72248137
111regulation of relaxation of muscle (GO:1901077)2.72115971
112* neural nucleus development (GO:0048857)2.72031010
113regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.71391984
114skeletal muscle fiber development (GO:0048741)2.70681901
115response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.70227990
116positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68353645
117astrocyte differentiation (GO:0048708)2.65497208
118regulation of glutamate receptor signaling pathway (GO:1900449)2.65206269
119thioester biosynthetic process (GO:0035384)2.63360432
120acyl-CoA biosynthetic process (GO:0071616)2.63360432
121regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.62291975
122negative regulation of myoblast differentiation (GO:0045662)2.61489810
123neuron remodeling (GO:0016322)2.61162319
124regulation of neuronal synaptic plasticity (GO:0048168)2.61123182
125regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.60614952
126regulation of synapse maturation (GO:0090128)2.59539796
127potassium ion homeostasis (GO:0055075)2.58909601
128glial cell differentiation (GO:0010001)2.58811840
129neuronal action potential propagation (GO:0019227)2.57383968
130membrane assembly (GO:0071709)2.55789481
131amyloid precursor protein catabolic process (GO:0042987)2.55660857
132peptidyl-cysteine modification (GO:0018198)2.55498059
133positive regulation of interleukin-17 production (GO:0032740)2.55397492
134negative regulation of JUN kinase activity (GO:0043508)2.54377050
135positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.53710744
136regulation of voltage-gated calcium channel activity (GO:1901385)2.53330069
137exploration behavior (GO:0035640)2.52964330
138dendrite morphogenesis (GO:0048813)2.52405228
139regulation of membrane repolarization (GO:0060306)2.51867491
140cardiac muscle contraction (GO:0060048)2.50751272
141auditory behavior (GO:0031223)2.50699834
142enteric nervous system development (GO:0048484)2.50032289
143pyrimidine nucleobase catabolic process (GO:0006208)2.49949373
144nerve growth factor signaling pathway (GO:0038180)2.49910844
145regulation of neurotransmitter levels (GO:0001505)2.49636221
146magnesium ion transport (GO:0015693)2.49574539
147regulation of calcium ion transmembrane transporter activity (GO:1901019)2.48910853
148regulation of calcium ion transmembrane transport (GO:1903169)2.48910853
149positive regulation of dendritic spine development (GO:0060999)2.47555532
150neurotransmitter uptake (GO:0001504)2.47201924
151actin filament depolymerization (GO:0030042)2.46456607
152axon development (GO:0061564)2.44669081
153regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.42743609
154myotube cell development (GO:0014904)2.42539571
155glutamate receptor signaling pathway (GO:0007215)2.42215483
156regulation of neurotransmitter secretion (GO:0046928)2.41417553
157L-glutamate transport (GO:0015813)2.41013985
158neuron-neuron synaptic transmission (GO:0007270)2.40685736
159regulation of neurotransmitter transport (GO:0051588)2.38883670
160myofibril assembly (GO:0030239)2.38575388
161acidic amino acid transport (GO:0015800)2.38130738
162regulation of neuron projection regeneration (GO:0070570)2.37825692
163regulation of axon regeneration (GO:0048679)2.37825692
164Golgi to plasma membrane protein transport (GO:0043001)2.37476256
165membrane depolarization (GO:0051899)2.37257962
166negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.37246739
167negative regulation of calcium ion transmembrane transport (GO:1903170)2.37246739
168* peripheral nervous system axon ensheathment (GO:0032292)2.36768475
169* myelination in peripheral nervous system (GO:0022011)2.36768475
170membrane protein ectodomain proteolysis (GO:0006509)2.36405918
171neuron recognition (GO:0008038)2.36057234
172negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.35959106
173neurotransmitter transport (GO:0006836)2.35487315
174positive regulation of membrane potential (GO:0045838)2.34212914
175ear development (GO:0043583)2.33892742
176interleukin-6-mediated signaling pathway (GO:0070102)2.33576291
177calcium ion-dependent exocytosis (GO:0017156)2.33234298
178negative regulation of cell morphogenesis involved in differentiation (GO:0010771)2.31137934
179response to muscle activity (GO:0014850)2.30293919
180ceramide biosynthetic process (GO:0046513)2.30279293
181negative regulation of neuron projection development (GO:0010977)2.27765515
182nucleotide transport (GO:0006862)2.26566127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.02737026
2SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.77841636
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.72298862
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.66570526
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.60784251
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.52247490
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.37836815
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34689804
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30617555
10AR_21572438_ChIP-Seq_LNCaP_Human2.27012636
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19751338
12DROSHA_22980978_ChIP-Seq_HELA_Human2.10530970
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.10474615
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03870708
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.01630297
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.96558550
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.96558550
18TAF15_26573619_Chip-Seq_HEK293_Human1.95757755
19OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94684974
20EZH2_27294783_Chip-Seq_ESCs_Mouse1.93139719
21EZH2_22144423_ChIP-Seq_EOC_Human1.92616511
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91076200
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88719128
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84443225
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83119058
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80863751
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80135830
28* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79541510
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.76269068
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70939643
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70461630
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.69060279
33ER_23166858_ChIP-Seq_MCF-7_Human1.68079230
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67318859
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66915190
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.65754709
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63612284
38* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63181072
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58582493
40LXR_22292898_ChIP-Seq_THP-1_Human1.56442103
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54871117
42CTCF_27219007_Chip-Seq_Bcells_Human1.53266947
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50685151
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50572685
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.41435355
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.41367388
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39199727
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38422736
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37495517
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35189660
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32261504
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31753610
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.29964228
54REST_21632747_ChIP-Seq_MESCs_Mouse1.29932279
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.29409993
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29111642
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28991873
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28991873
59* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28580527
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27980500
61VDR_22108803_ChIP-Seq_LS180_Human1.26962697
62* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26818931
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.25403072
64POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24252378
65STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22103611
66P300_19829295_ChIP-Seq_ESCs_Human1.20830895
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20482260
68SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.19972414
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.19156251
70P68_20966046_ChIP-Seq_HELA_Human1.16327204
71CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15680628
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.14693446
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13933193
74OCT4_19829295_ChIP-Seq_ESCs_Human1.13801919
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12465915
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12464256
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12089159
78BCL6_27268052_Chip-Seq_Bcells_Human1.10688309
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10447373
80KDM2B_26808549_Chip-Seq_K562_Human1.08441703
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07574769
82SA1_27219007_Chip-Seq_Bcells_Human1.07524212
83FUS_26573619_Chip-Seq_HEK293_Human1.07265787
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.06986584
85SMC4_20622854_ChIP-Seq_HELA_Human1.06969318
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06888376
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06533747
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06508712
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06028544
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05837536
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.05652953
92GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05133871
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05006452
94EOMES_21245162_ChIP-Seq_HESCs_Human1.04962389
95STAT3_23295773_ChIP-Seq_U87_Human1.04123872
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03449292
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03226076
98SMAD4_21799915_ChIP-Seq_A2780_Human1.01379196
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00629819
100CTCF_20526341_ChIP-Seq_ESCs_Human0.99445060
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98752302
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98696918
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97728004
104PRDM14_20953172_ChIP-Seq_ESCs_Human0.97403094
105NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97081204
106RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96488643
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95608282
108TCF4_23295773_ChIP-Seq_U87_Human0.95086118
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.94850151
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94603608
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.94501921
112CMYC_18555785_Chip-Seq_ESCs_Mouse0.94469433
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94109621
114BCOR_27268052_Chip-Seq_Bcells_Human0.94040994
115TAL1_26923725_Chip-Seq_HPCs_Mouse0.93762111
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92916832
117* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92625675
118SOX2_21211035_ChIP-Seq_LN229_Gbm0.91665295
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.91522424
120ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91219690
121SA1_27219007_Chip-Seq_ERYTHROID_Human0.91172662
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90637406
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90637406
124TP63_22573176_ChIP-Seq_HFKS_Human0.90636945
125KLF4_19829295_ChIP-Seq_ESCs_Human0.89991703
126HTT_18923047_ChIP-ChIP_STHdh_Human0.89525743
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89366641
128AHR_22903824_ChIP-Seq_MCF-7_Human0.89240341
129TAF2_19829295_ChIP-Seq_ESCs_Human0.88587549
130OCT4_20526341_ChIP-Seq_ESCs_Human0.88387800
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88190922
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87629937
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86818304
134P300_18555785_Chip-Seq_ESCs_Mouse0.86779794
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86659783
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86348368
137RUNX2_22187159_ChIP-Seq_PCA_Human0.85842696
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85566521
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84780550
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.84734279
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.84662147
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84643109
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84443183
144EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84033918
145TBL1_22424771_ChIP-Seq_293T_Human0.83733943
146TP53_23651856_ChIP-Seq_MEFs_Mouse0.83511035
147* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83450361
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83098860
149RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83052307
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.82567938
151ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82435755
152TET1_21451524_ChIP-Seq_MESCs_Mouse0.80726136
153E2F1_20622854_ChIP-Seq_HELA_Human0.79638520
154TP53_20018659_ChIP-ChIP_R1E_Mouse0.79299675
155GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79028964
156RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78654646
157CTCF_27219007_Chip-Seq_ERYTHROID_Human0.77796560
158KDM2B_26808549_Chip-Seq_DND41_Human0.77337193
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75107212
160SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.75034052
161MYC_19829295_ChIP-Seq_ESCs_Human0.74881372
162FOXH1_21741376_ChIP-Seq_ESCs_Human0.74447538
163* ERA_21632823_ChIP-Seq_H3396_Human0.73718173
164ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73116210
165EGR1_19032775_ChIP-ChIP_M12_Human0.72847141
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.72480127
167STAT1_20625510_ChIP-Seq_HELA_Human0.71972319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.69918695
2MP0003690_abnormal_glial_cell3.87564371
3MP0003880_abnormal_central_pattern3.86431673
4MP0003646_muscle_fatigue3.24616183
5MP0004742_abnormal_vestibular_system3.11772808
6MP0004270_analgesia2.85269511
7MP0004885_abnormal_endolymph2.84254468
8MP0005171_absent_coat_pigmentation2.72976841
9MP0001529_abnormal_vocalization2.70658004
10MP0003329_amyloid_beta_deposits2.66857631
11MP0003634_abnormal_glial_cell2.61004489
12MP0002272_abnormal_nervous_system2.52698676
13MP0001905_abnormal_dopamine_level2.46479601
14MP0001486_abnormal_startle_reflex2.45849074
15MP0002064_seizures2.40758948
16MP0000751_myopathy2.39171617
17MP0000778_abnormal_nervous_system2.38096833
18MP0004859_abnormal_synaptic_plasticity2.36572567
19MP0001485_abnormal_pinna_reflex2.36266883
20MP0003136_yellow_coat_color2.30881653
21MP0004130_abnormal_muscle_cell2.29219870
22MP0003950_abnormal_plasma_membrane2.23965227
23MP0003879_abnormal_hair_cell2.12064890
24MP0004142_abnormal_muscle_tone2.09635101
25MP0005167_abnormal_blood-brain_barrier1.95030035
26MP0000462_abnormal_digestive_system1.90379528
27MP0003632_abnormal_nervous_system1.90016338
28MP0009046_muscle_twitch1.87574552
29MP0009745_abnormal_behavioral_response1.87227396
30MP0002229_neurodegeneration1.86204312
31MP0004134_abnormal_chest_morphology1.84547206
32MP0003635_abnormal_synaptic_transmissio1.81012863
33MP0005409_darkened_coat_color1.76157761
34MP0002332_abnormal_exercise_endurance1.70671020
35MP0001440_abnormal_grooming_behavior1.70063007
36MP0005451_abnormal_body_composition1.69368580
37MP0005410_abnormal_fertilization1.61763554
38MP0002734_abnormal_mechanical_nocicepti1.61247078
39MP0004510_myositis1.51085175
40MP0000604_amyloidosis1.50975539
41MP0000955_abnormal_spinal_cord1.48869890
42MP0002882_abnormal_neuron_morphology1.47953996
43MP0005551_abnormal_eye_electrophysiolog1.47185635
44MP0005623_abnormal_meninges_morphology1.46688914
45MP0005423_abnormal_somatic_nervous1.45205507
46MP0002572_abnormal_emotion/affect_behav1.44708295
47MP0002106_abnormal_muscle_physiology1.43938645
48MP0002822_catalepsy1.42251207
49MP0004145_abnormal_muscle_electrophysio1.38659319
50MP0004381_abnormal_hair_follicle1.36829734
51MP0001299_abnormal_eye_distance/1.34334763
52MP0000759_abnormal_skeletal_muscle1.33556416
53MP0003172_abnormal_lysosome_physiology1.33296673
54MP0002653_abnormal_ependyma_morphology1.31761270
55MP0008569_lethality_at_weaning1.31663753
56MP0002063_abnormal_learning/memory/cond1.30848135
57MP0006276_abnormal_autonomic_nervous1.29801767
58MP0002067_abnormal_sensory_capabilities1.28271457
59MP0002066_abnormal_motor_capabilities/c1.28247212
60MP0003631_nervous_system_phenotype1.26678763
61MP0001963_abnormal_hearing_physiology1.24182931
62MP0004147_increased_porphyrin_level1.24146543
63MP0000383_abnormal_hair_follicle1.22949336
64MP0005620_abnormal_muscle_contractility1.22880327
65MP0002090_abnormal_vision1.22382767
66MP0002752_abnormal_somatic_nervous1.19928908
67MP0010678_abnormal_skin_adnexa1.18803809
68MP0005670_abnormal_white_adipose1.18743973
69MP0005369_muscle_phenotype1.17740230
70MP0000747_muscle_weakness1.16370954
71MP0004924_abnormal_behavior1.15748200
72MP0005386_behavior/neurological_phenoty1.15748200
73MP0002837_dystrophic_cardiac_calcinosis1.15571187
74MP0003075_altered_response_to1.13765524
75MP0001970_abnormal_pain_threshold1.13499754
76MP0004087_abnormal_muscle_fiber1.13178812
77MP0005058_abnormal_lysosome_morphology1.11876392
78MP0001661_extended_life_span1.11094813
79MP0002269_muscular_atrophy1.09745813
80MP0009840_abnormal_foam_cell1.08679346
81MP0002733_abnormal_thermal_nociception1.08605966
82MP0000750_abnormal_muscle_regeneration1.08375789
83MP0003137_abnormal_impulse_conducting1.06095880
84MP0003633_abnormal_nervous_system1.04255180
85MP0004215_abnormal_myocardial_fiber1.00910809
86MP0009780_abnormal_chondrocyte_physiolo1.00763488
87MP0005535_abnormal_body_temperature0.99413552
88MP0005195_abnormal_posterior_eye0.98591784
89MP0002295_abnormal_pulmonary_circulatio0.98291742
90MP0001968_abnormal_touch/_nociception0.96178790
91MP0002876_abnormal_thyroid_physiology0.93659775
92MP0002972_abnormal_cardiac_muscle0.93052170
93MP0004484_altered_response_of0.92740847
94MP0004185_abnormal_adipocyte_glucose0.92580612
95MP0004084_abnormal_cardiac_muscle0.91656427
96MP0008874_decreased_physiological_sensi0.88911379
97MP0006036_abnormal_mitochondrial_physio0.87951998
98MP0002638_abnormal_pupillary_reflex0.86849053
99MP0005408_hypopigmentation0.86343850
100MP0003938_abnormal_ear_development0.85999924
101MP0003806_abnormal_nucleotide_metabolis0.85931092
102MP0001177_atelectasis0.84668232
103MP0002736_abnormal_nociception_after0.83686086
104MP0002152_abnormal_brain_morphology0.83619857
105MP0005253_abnormal_eye_physiology0.83562133
106MP0003195_calcinosis0.82172575
107MP0001986_abnormal_taste_sensitivity0.82086216
108MP0004043_abnormal_pH_regulation0.81764378
109MP0006082_CNS_inflammation0.80155025
110MP0001984_abnormal_olfaction0.80031308
111MP0000647_abnormal_sebaceous_gland0.78755368
112MP0000343_altered_response_to0.77852106
113MP0001851_eye_inflammation0.77315879
114MP0000026_abnormal_inner_ear0.76594887
115MP0000467_abnormal_esophagus_morphology0.75596567
116MP0002184_abnormal_innervation0.74377034
117MP0005166_decreased_susceptibility_to0.73769308
118MP0002735_abnormal_chemical_nociception0.73767295
119MP0005310_abnormal_salivary_gland0.73532314
120MP0003787_abnormal_imprinting0.73504652
121MP0002971_abnormal_brown_adipose0.72683118
122MP0002557_abnormal_social/conspecific_i0.71824205
123MP0001346_abnormal_lacrimal_gland0.71307523
124MP0008438_abnormal_cutaneous_collagen0.71019308
125MP0000566_synostosis0.70537025
126MP0009384_cardiac_valve_regurgitation0.70050875
127MP0000762_abnormal_tongue_morphology0.69624643
128MP0003011_delayed_dark_adaptation0.69205774
129MP0000749_muscle_degeneration0.62079113
130MP0001501_abnormal_sleep_pattern0.61531379
131MP0004036_abnormal_muscle_relaxation0.61271943
132MP0004811_abnormal_neuron_physiology0.58418754
133MP0003937_abnormal_limbs/digits/tail_de0.57759837
134MP0001727_abnormal_embryo_implantation0.56221446
135MP0002133_abnormal_respiratory_system0.55859210
136MP0005388_respiratory_system_phenotype0.55859210
137MP0001502_abnormal_circadian_rhythm0.55491676
138MP0005646_abnormal_pituitary_gland0.55148190

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.28113919
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.28113919
3Sensory axonal neuropathy (HP:0003390)5.98549234
4Neurofibrillary tangles (HP:0002185)5.86130200
5Muscle fiber inclusion bodies (HP:0100299)5.70437029
6Nemaline bodies (HP:0003798)5.59090026
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.51246520
8Peripheral hypomyelination (HP:0007182)4.79644679
9Abnormality of the corticospinal tract (HP:0002492)4.78124154
10Exercise-induced myalgia (HP:0003738)4.62891086
11Parakeratosis (HP:0001036)4.53586978
12Type 1 muscle fiber predominance (HP:0003803)4.43001204
13Cerebral inclusion bodies (HP:0100314)4.05306893
14Cerebral hypomyelination (HP:0006808)4.00674584
15Muscle fiber splitting (HP:0003555)3.90544623
16Akinesia (HP:0002304)3.85689362
17Hyporeflexia of lower limbs (HP:0002600)3.78554334
18Focal motor seizures (HP:0011153)3.75721148
19Supranuclear gaze palsy (HP:0000605)3.75228992
20Exercise-induced muscle cramps (HP:0003710)3.63523604
21EMG: myopathic abnormalities (HP:0003458)3.61855921
22Intention tremor (HP:0002080)3.61582927
23Spastic gait (HP:0002064)3.54514479
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.54403207
25Muscle hypertrophy of the lower extremities (HP:0008968)3.46336652
26Myopathic facies (HP:0002058)3.44296880
27Premature skin wrinkling (HP:0100678)3.39069075
28Alacrima (HP:0000522)3.36886932
29Round ear (HP:0100830)3.36154060
30Distal arthrogryposis (HP:0005684)3.33994129
31Onion bulb formation (HP:0003383)3.31238620
32Abnormality of glycolysis (HP:0004366)3.31107006
33Increased serum pyruvate (HP:0003542)3.31107006
34Dysmetria (HP:0001310)3.18107546
35Calf muscle hypertrophy (HP:0008981)3.15532689
36Abnormality of binocular vision (HP:0011514)3.15393304
37Diplopia (HP:0000651)3.15393304
38Abnormal auditory evoked potentials (HP:0006958)3.10420922
39Focal seizures (HP:0007359)3.09562133
40Leukodystrophy (HP:0002415)3.02913959
41Spastic paraparesis (HP:0002313)3.00352063
42Bundle branch block (HP:0011710)2.95553065
43Frequent falls (HP:0002359)2.93214357
44Slow saccadic eye movements (HP:0000514)2.91490813
45Atonic seizures (HP:0010819)2.78678906
46Termporal pattern (HP:0011008)2.72827075
47Insidious onset (HP:0003587)2.72827075
48Asymmetric septal hypertrophy (HP:0001670)2.71711877
49Centrally nucleated skeletal muscle fibers (HP:0003687)2.71583810
50Decreased lacrimation (HP:0000633)2.71529001
51Hypoplastic pelvis (HP:0008839)2.69218616
52Abnormality of the calf musculature (HP:0001430)2.68533165
53Myoglobinuria (HP:0002913)2.67936706
54Increased circulating renin level (HP:0000848)2.67516669
55Retinal dysplasia (HP:0007973)2.67219313
56Scanning speech (HP:0002168)2.65284022
57Mutism (HP:0002300)2.63700206
58Small epiphyses (HP:0010585)2.62416554
59Difficulty running (HP:0009046)2.61306321
60Abnormal eating behavior (HP:0100738)2.58249794
61Visual hallucinations (HP:0002367)2.57547439
62Clumsiness (HP:0002312)2.56240103
63Ulnar deviation of the wrist (HP:0003049)2.55911495
64Abnormality of skeletal muscle fiber size (HP:0012084)2.55492983
65Rhabdomyolysis (HP:0003201)2.54782542
66Sudden death (HP:0001699)2.54414771
67Hemiplegia (HP:0002301)2.54128512
68Congenital ichthyosiform erythroderma (HP:0007431)2.52855974
69Myotonia (HP:0002486)2.50115206
70Febrile seizures (HP:0002373)2.50071177
71Neck muscle weakness (HP:0000467)2.48983923
72Increased variability in muscle fiber diameter (HP:0003557)2.45375506
73Weak cry (HP:0001612)2.44398056
74White forelock (HP:0002211)2.40115003
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.39975363
76Polyphagia (HP:0002591)2.39142555
77Stridor (HP:0010307)2.37553118
78Cerebral hemorrhage (HP:0001342)2.36534053
79Renal Fanconi syndrome (HP:0001994)2.35844779
80Morphological abnormality of the inner ear (HP:0011390)2.34677645
81Partial agenesis of the corpus callosum (HP:0001338)2.33353362
82EMG: neuropathic changes (HP:0003445)2.31508522
83Heart block (HP:0012722)2.29730184
84Patchy hypopigmentation of hair (HP:0011365)2.29279148
85Abnormality of the parathyroid morphology (HP:0011766)2.26406336
86Pheochromocytoma (HP:0002666)2.25553715
87Gowers sign (HP:0003391)2.24447047
88Myokymia (HP:0002411)2.23535644
89Postural instability (HP:0002172)2.22116420
90Generalized tonic-clonic seizures (HP:0002069)2.21900368
91Adrenal hypoplasia (HP:0000835)2.21701277
92Hypomagnesemia (HP:0002917)2.21625443
93Ankle clonus (HP:0011448)2.20312186
94Bulbar palsy (HP:0001283)2.16976991
95CNS hypomyelination (HP:0003429)2.16835935
96Hepatosplenomegaly (HP:0001433)2.16704033
97Paraparesis (HP:0002385)2.14604732
98Epileptic encephalopathy (HP:0200134)2.14239517
99Abnormal atrioventricular conduction (HP:0005150)2.13796608
100Subaortic stenosis (HP:0001682)2.11129465
101Abnormality of the left ventricular outflow tract (HP:0011103)2.11129465
102Progressive cerebellar ataxia (HP:0002073)2.10993245
103Foot dorsiflexor weakness (HP:0009027)2.10455501
104Malignant hyperthermia (HP:0002047)2.09732913
105Thickened helices (HP:0000391)2.09656029
106Anomalous pulmonary venous return (HP:0010772)2.08639774
107Distal lower limb muscle weakness (HP:0009053)2.08446244
108Absent septum pellucidum (HP:0001331)2.08216168
109Anteriorly placed anus (HP:0001545)2.08197090
110Muscle stiffness (HP:0003552)2.07164836
111Generalized muscle weakness (HP:0003324)2.06010787
112Generalized myoclonic seizures (HP:0002123)2.05516939
113Rapidly progressive (HP:0003678)2.05475721
114Ventricular fibrillation (HP:0001663)2.05461223
115Lower limb muscle weakness (HP:0007340)2.05084659
116Diminished movement (HP:0002374)2.04582448
117Abolished electroretinogram (ERG) (HP:0000550)2.04500261
118Rigidity (HP:0002063)2.04411625
119Spastic tetraparesis (HP:0001285)2.04229242
120Hemiparesis (HP:0001269)2.04156581
121Abnormality of the foot musculature (HP:0001436)2.01537290
122Limb dystonia (HP:0002451)1.99644325
123Fatigable weakness (HP:0003473)1.98356389
124Abnormality of the neuromuscular junction (HP:0003398)1.98356389
125Type 2 muscle fiber atrophy (HP:0003554)1.98257455
126Bowel incontinence (HP:0002607)1.97920759
127Neuroendocrine neoplasm (HP:0100634)1.97770129
128Prolonged QT interval (HP:0001657)1.97512937
129Hypoplasia of the iris (HP:0007676)1.97389137
130Action tremor (HP:0002345)1.96310850
131Coronal craniosynostosis (HP:0004440)1.95262685
132Split foot (HP:0001839)1.94030014
133Poor speech (HP:0002465)1.92620092
134Cupped ear (HP:0000378)1.92566254
135Autoamputation (HP:0001218)1.89835824
136Obstructive sleep apnea (HP:0002870)1.89562996
137Aplasia involving bones of the extremities (HP:0009825)1.89383980
138Aplasia involving bones of the upper limbs (HP:0009823)1.89383980
139Aplasia of the phalanges of the hand (HP:0009802)1.89383980
140Infantile muscular hypotonia (HP:0008947)1.88808841
141Abnormal EKG (HP:0003115)1.87913626
142Metabolic alkalosis (HP:0200114)1.86207081
143Epiphyseal dysplasia (HP:0002656)1.84880149
144Urinary bladder sphincter dysfunction (HP:0002839)1.84731718
145Barrel-shaped chest (HP:0001552)1.84087625
146Delusions (HP:0000746)1.84023840
147Fetal akinesia sequence (HP:0001989)1.83406095
148Tetraplegia (HP:0002445)1.83091390
149Muscle fiber atrophy (HP:0100295)1.82900496
150Abnormal large intestine physiology (HP:0012700)1.82062774
151Absent phalangeal crease (HP:0006109)1.81542103
152Esophageal atresia (HP:0002032)1.78765050
153Ventricular arrhythmia (HP:0004308)1.77550851
154Neuronal loss in central nervous system (HP:0002529)1.77304725
155Nonprogressive disorder (HP:0003680)1.77025719
156Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76785838
157Absence seizures (HP:0002121)1.73652967
158Segmental peripheral demyelination/remyelination (HP:0003481)1.73533937
159Lower limb amyotrophy (HP:0007210)1.73533598
160Abnormality of the pulmonary veins (HP:0011718)1.72951646
161Rimmed vacuoles (HP:0003805)1.72709924
162Relative macrocephaly (HP:0004482)1.72154682
163Morphological abnormality of the pyramidal tract (HP:0002062)1.71751428
164Septo-optic dysplasia (HP:0100842)1.71245815
165Areflexia of lower limbs (HP:0002522)1.71175476
166Hypokalemic alkalosis (HP:0001949)1.70865925
167Abnormality of the vitreous humor (HP:0004327)1.69321287
168Steppage gait (HP:0003376)1.69028208
169Abnormality of the septum pellucidum (HP:0007375)1.68991102
170Acute necrotizing encephalopathy (HP:0006965)1.68766941
171Megalencephaly (HP:0001355)1.68611945
172Dysdiadochokinesis (HP:0002075)1.68110309
173Abnormality of magnesium homeostasis (HP:0004921)1.66766740
174Urinary incontinence (HP:0000020)1.66520808
175Synostosis involving the elbow (HP:0003938)1.66096115
176Humeroradial synostosis (HP:0003041)1.66096115
177Thick nail (HP:0001805)1.63774735
178Type II lissencephaly (HP:0007260)1.63519511
179Methylmalonic acidemia (HP:0002912)1.62021133
180Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.61921365
181Chin dimple (HP:0010751)1.61336423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.98149227
2TNIK4.41059601
3OXSR14.04984201
4EPHB13.66848760
5PRPF4B3.04345104
6TYRO32.88264451
7PKN12.60478814
8BCR2.59812192
9WNK42.52419678
10DAPK22.46754389
11ICK2.42306052
12PINK12.06064881
13UHMK12.00349746
14MAP3K111.99320938
15FES1.98599568
16PBK1.97457236
17CDK191.96072289
18NEK61.94106718
19MET1.88014580
20LIMK11.81050292
21PRKD31.74867090
22IRAK21.72998685
23MAPK121.68451949
24WNK11.65959620
25FGFR21.62860172
26CASK1.58118520
27TNK21.56742123
28ROCK21.55280175
29TTN1.46156748
30NTRK11.45970093
31RIPK41.45898114
32CSNK1G31.45552069
33CAMKK11.38360245
34MAPKAPK51.37545306
35SIK21.36140692
36CSNK1A1L1.35440927
37FGR1.34434735
38IRAK11.33910505
39EPHA41.33506082
40TESK11.31197192
41PAK61.26103785
42CLK11.18926716
43MST41.17860822
44MAPK131.15731995
45CAMK11.15728920
46PNCK1.12148206
47CSNK1G21.07027407
48CAMK2D1.05430504
49CSNK1G11.04765350
50CAMKK21.04646069
51CAMK2B1.04502567
52PIK3CG1.00215150
53PRKCQ0.99408067
54DDR20.97002648
55IRAK40.93037091
56MOS0.91466056
57SGK2230.91110811
58SGK4940.91110811
59MAPKAPK30.90931192
60MARK10.89436566
61GRK50.89231517
62CSK0.88372054
63PDGFRB0.84846136
64MAP2K40.81816112
65PAK30.80774307
66INSRR0.77758776
67CDK50.77185747
68MAP3K70.76703950
69DYRK20.76564913
70BCKDK0.74938381
71CDK140.74770748
72ROCK10.73422470
73PHKG20.72918056
74PHKG10.72918056
75FYN0.72205708
76TESK20.70970211
77BLK0.70606222
78MARK20.70582697
79CAMK2G0.69882412
80CAMK40.69105427
81MAPK150.68332096
82CAMK2A0.67986139
83DAPK30.66760471
84TRIB30.64898758
85MAP3K20.64115397
86TIE10.61205573
87PDPK10.60705262
88STK380.60652348
89MAP2K60.60624728
90DYRK1B0.59285675
91ARAF0.58381158
92CDC42BPA0.58114582
93CDK150.57279315
94PRKCZ0.57008749
95SGK20.56371112
96DMPK0.56308485
97EPHA30.54849835
98NTRK20.54762444
99SGK30.53722005
100PRKCE0.53660091
101CDK180.53304311
102ZAP700.52106344
103SYK0.51841831
104MAP2K10.51828588
105CDK11A0.51275687
106PRKD10.51269777
107PLK20.50292996
108INSR0.48959754
109RIPK10.48506411
110PRKCH0.47451639
111KSR20.47390035
112ERBB40.45544584
113MAP3K130.45266443
114SGK10.45022257
115MAP2K30.44417797
116TXK0.43322991
117DYRK1A0.41828347
118MAPK100.39403803
119GSK3A0.39193698
120PRKD20.39159462
121PRKG10.38872309
122MAP3K10.38690795
123MAP3K90.38441105
124PTK20.37551938
125MINK10.36161817
126GRK70.34527423
127PDK10.33953476
128CSNK1D0.32706811
129ITK0.29921783
130PIK3CA0.29179124
131PRKACA0.29177328
132LCK0.28555169
133MUSK0.28309648
134CSNK1A10.28180712
135SRC0.27771817
136PTK2B0.26893279
137PRKACB0.26387576
138STK110.26331252
139OBSCN0.25373619
140BMX0.23994735
141ADRBK20.23614862
142PRKCG0.22981245
143NTRK30.22754418
144ABL20.21155463
145MAPK70.20814799
146PAK10.18937084
147RET0.17867350
148NUAK10.17016331

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.55412686
2Steroid biosynthesis_Homo sapiens_hsa001004.91543764
3Fatty acid elongation_Homo sapiens_hsa000623.87264994
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.83776755
5Ether lipid metabolism_Homo sapiens_hsa005653.11313119
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18351757
7Axon guidance_Homo sapiens_hsa043602.14607180
8Oxidative phosphorylation_Homo sapiens_hsa001902.10183453
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02260423
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.94763313
11Insulin secretion_Homo sapiens_hsa049111.86447066
12Sphingolipid metabolism_Homo sapiens_hsa006001.81577386
13Sulfur metabolism_Homo sapiens_hsa009201.76249270
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.65488116
15Calcium signaling pathway_Homo sapiens_hsa040201.61751404
16Butanoate metabolism_Homo sapiens_hsa006501.61276906
17Dilated cardiomyopathy_Homo sapiens_hsa054141.57034664
18Amphetamine addiction_Homo sapiens_hsa050311.56537700
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53097723
20Glutamatergic synapse_Homo sapiens_hsa047241.42449436
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42289131
22Collecting duct acid secretion_Homo sapiens_hsa049661.41921625
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41312407
24Alzheimers disease_Homo sapiens_hsa050101.38513776
25Protein export_Homo sapiens_hsa030601.33068642
26Vitamin B6 metabolism_Homo sapiens_hsa007501.32354544
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31583628
28Parkinsons disease_Homo sapiens_hsa050121.29295329
29Serotonergic synapse_Homo sapiens_hsa047261.26504728
30Renal cell carcinoma_Homo sapiens_hsa052111.20799981
31beta-Alanine metabolism_Homo sapiens_hsa004101.18093750
32Vibrio cholerae infection_Homo sapiens_hsa051101.15147152
33Linoleic acid metabolism_Homo sapiens_hsa005911.13240117
34GABAergic synapse_Homo sapiens_hsa047271.13077755
35Fatty acid metabolism_Homo sapiens_hsa012121.12622758
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10160075
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.09652092
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09305029
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06655755
40Long-term depression_Homo sapiens_hsa047301.06465159
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05508310
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01400050
43Olfactory transduction_Homo sapiens_hsa047401.00611978
44Cholinergic synapse_Homo sapiens_hsa047250.99678444
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.98733109
46Rheumatoid arthritis_Homo sapiens_hsa053230.98541321
47Sphingolipid signaling pathway_Homo sapiens_hsa040710.97120730
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92136766
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91345046
50GnRH signaling pathway_Homo sapiens_hsa049120.90356497
51Lysosome_Homo sapiens_hsa041420.89279104
52Synaptic vesicle cycle_Homo sapiens_hsa047210.87961321
53Arginine and proline metabolism_Homo sapiens_hsa003300.85598051
54Morphine addiction_Homo sapiens_hsa050320.85597288
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85405480
56Bile secretion_Homo sapiens_hsa049760.83725103
57Endocytosis_Homo sapiens_hsa041440.83161267
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82169703
59Nitrogen metabolism_Homo sapiens_hsa009100.81203226
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77081847
61Tight junction_Homo sapiens_hsa045300.76726713
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76632633
63VEGF signaling pathway_Homo sapiens_hsa043700.76157582
64Cardiac muscle contraction_Homo sapiens_hsa042600.74179820
65Sulfur relay system_Homo sapiens_hsa041220.73831971
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73113882
67Fatty acid biosynthesis_Homo sapiens_hsa000610.71761287
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70374829
69PPAR signaling pathway_Homo sapiens_hsa033200.69154470
70Phagosome_Homo sapiens_hsa041450.69083093
71Circadian rhythm_Homo sapiens_hsa047100.69045052
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68839904
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.68398039
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68109967
75Propanoate metabolism_Homo sapiens_hsa006400.67676137
76Choline metabolism in cancer_Homo sapiens_hsa052310.67415556
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66046385
78Ras signaling pathway_Homo sapiens_hsa040140.65991150
79Taste transduction_Homo sapiens_hsa047420.65075659
80MAPK signaling pathway_Homo sapiens_hsa040100.64865944
81Glucagon signaling pathway_Homo sapiens_hsa049220.63916289
82Prion diseases_Homo sapiens_hsa050200.63909635
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62244364
84Ovarian steroidogenesis_Homo sapiens_hsa049130.62200321
85Huntingtons disease_Homo sapiens_hsa050160.61605502
86Circadian entrainment_Homo sapiens_hsa047130.61597677
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61309778
88Salivary secretion_Homo sapiens_hsa049700.61209035
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.61153134
90Peroxisome_Homo sapiens_hsa041460.60897522
91Estrogen signaling pathway_Homo sapiens_hsa049150.59718004
92ErbB signaling pathway_Homo sapiens_hsa040120.59222353
93Histidine metabolism_Homo sapiens_hsa003400.58727805
94Dopaminergic synapse_Homo sapiens_hsa047280.58054388
95Arginine biosynthesis_Homo sapiens_hsa002200.57086768
96Insulin signaling pathway_Homo sapiens_hsa049100.56952597
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.56477723
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56333937
99Arachidonic acid metabolism_Homo sapiens_hsa005900.55816748
100Dorso-ventral axis formation_Homo sapiens_hsa043200.54116931
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53072932
102Malaria_Homo sapiens_hsa051440.51420353
103Type II diabetes mellitus_Homo sapiens_hsa049300.51364469
104Nicotine addiction_Homo sapiens_hsa050330.50043384
105Phototransduction_Homo sapiens_hsa047440.49928492
106Pancreatic secretion_Homo sapiens_hsa049720.49757963
107Other glycan degradation_Homo sapiens_hsa005110.49275209
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48348055
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48097100
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.47955657
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47825962
112Gastric acid secretion_Homo sapiens_hsa049710.47544646
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.46650026
114Glutathione metabolism_Homo sapiens_hsa004800.44788353
115ABC transporters_Homo sapiens_hsa020100.44467571
116ECM-receptor interaction_Homo sapiens_hsa045120.44432827
117Gap junction_Homo sapiens_hsa045400.43802037
118AMPK signaling pathway_Homo sapiens_hsa041520.43236225
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42824053
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.42526320
121Regulation of autophagy_Homo sapiens_hsa041400.42505375
122Autoimmune thyroid disease_Homo sapiens_hsa053200.41763604
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40052280
124Cocaine addiction_Homo sapiens_hsa050300.36664581
125T cell receptor signaling pathway_Homo sapiens_hsa046600.36140770
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33307738
127Chemokine signaling pathway_Homo sapiens_hsa040620.31827557
128Renin secretion_Homo sapiens_hsa049240.31231109
129Oxytocin signaling pathway_Homo sapiens_hsa049210.31030043
130cAMP signaling pathway_Homo sapiens_hsa040240.28693799
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28630887
132Metabolic pathways_Homo sapiens_hsa011000.28327302
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27737126
134Mineral absorption_Homo sapiens_hsa049780.26857154
135Salmonella infection_Homo sapiens_hsa051320.26471590
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26257906
137Platelet activation_Homo sapiens_hsa046110.25747469
138Long-term potentiation_Homo sapiens_hsa047200.25159622
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24809341
140Fatty acid degradation_Homo sapiens_hsa000710.24749508
141Glycerolipid metabolism_Homo sapiens_hsa005610.24356491

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