SIRT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.80845538
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.80845538
3L-phenylalanine metabolic process (GO:0006558)5.65820365
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.65820365
5lysine catabolic process (GO:0006554)5.43517737
6lysine metabolic process (GO:0006553)5.43517737
7tricarboxylic acid cycle (GO:0006099)5.31931668
8aromatic amino acid family catabolic process (GO:0009074)5.27957492
92-oxoglutarate metabolic process (GO:0006103)5.22107055
10kynurenine metabolic process (GO:0070189)5.21825243
11glyoxylate metabolic process (GO:0046487)5.03057127
12indolalkylamine catabolic process (GO:0046218)5.00450334
13tryptophan catabolic process (GO:0006569)5.00450334
14indole-containing compound catabolic process (GO:0042436)5.00450334
15oxaloacetate metabolic process (GO:0006107)4.96349160
16cellular ketone body metabolic process (GO:0046950)4.86933464
17tryptophan metabolic process (GO:0006568)4.84468889
18NADH metabolic process (GO:0006734)4.79242579
19alpha-linolenic acid metabolic process (GO:0036109)4.78688977
20behavioral response to nicotine (GO:0035095)4.76101468
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.66227154
22bile acid biosynthetic process (GO:0006699)4.47839991
23valine metabolic process (GO:0006573)4.43220193
24aspartate family amino acid catabolic process (GO:0009068)4.34814040
25regulation of triglyceride catabolic process (GO:0010896)4.32428312
26branched-chain amino acid catabolic process (GO:0009083)4.25279717
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.18851408
28succinate metabolic process (GO:0006105)4.18157590
29ketone body metabolic process (GO:1902224)4.18141578
30ubiquinone biosynthetic process (GO:0006744)4.18071624
31cysteine metabolic process (GO:0006534)4.15488206
32fatty acid beta-oxidation (GO:0006635)4.12747732
33sulfur amino acid catabolic process (GO:0000098)4.11568198
34alpha-amino acid catabolic process (GO:1901606)4.10381929
35amino-acid betaine metabolic process (GO:0006577)4.07454891
36regulation of protein activation cascade (GO:2000257)4.01945917
37negative regulation of fibrinolysis (GO:0051918)4.01439640
38serine family amino acid catabolic process (GO:0009071)3.98371571
39short-chain fatty acid metabolic process (GO:0046459)3.97428095
40acetyl-CoA metabolic process (GO:0006084)3.92317348
41aromatic amino acid family metabolic process (GO:0009072)3.90349325
42ethanol oxidation (GO:0006069)3.90123189
43urea metabolic process (GO:0019627)3.89470737
44urea cycle (GO:0000050)3.89470737
45high-density lipoprotein particle remodeling (GO:0034375)3.89307140
46homocysteine metabolic process (GO:0050667)3.89142547
47branched-chain amino acid metabolic process (GO:0009081)3.87618980
48complement activation, alternative pathway (GO:0006957)3.86666465
49fatty acid catabolic process (GO:0009062)3.85345294
50coenzyme catabolic process (GO:0009109)3.81393605
51cellular amino acid catabolic process (GO:0009063)3.79815435
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.79489403
53regulation of complement activation (GO:0030449)3.79335206
54tricarboxylic acid metabolic process (GO:0072350)3.76641846
55fatty acid oxidation (GO:0019395)3.75375860
56fatty acid transmembrane transport (GO:1902001)3.74841947
57oxidative phosphorylation (GO:0006119)3.74355333
58dicarboxylic acid biosynthetic process (GO:0043650)3.73925119
59regulation of fibrinolysis (GO:0051917)3.73545431
60ubiquinone metabolic process (GO:0006743)3.73350761
61glycine metabolic process (GO:0006544)3.73258537
62carnitine shuttle (GO:0006853)3.71411926
63monocarboxylic acid catabolic process (GO:0072329)3.69017021
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68800278
65mitochondrial respiratory chain complex I assembly (GO:0032981)3.68800278
66NADH dehydrogenase complex assembly (GO:0010257)3.68800278
67bile acid metabolic process (GO:0008206)3.67967771
68protein complex biogenesis (GO:0070271)3.67604356
69lipid oxidation (GO:0034440)3.66907652
70NAD metabolic process (GO:0019674)3.65749198
71respiratory chain complex IV assembly (GO:0008535)3.64588611
72tyrosine metabolic process (GO:0006570)3.60543141
73quinone biosynthetic process (GO:1901663)3.59880564
74organic acid catabolic process (GO:0016054)3.57756223
75carboxylic acid catabolic process (GO:0046395)3.57756223
76cellular modified amino acid catabolic process (GO:0042219)3.57287511
77negative regulation of telomere maintenance (GO:0032205)3.55725354
78indolalkylamine metabolic process (GO:0006586)3.53142865
79nitrogen cycle metabolic process (GO:0071941)3.51484492
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.50282211
81biotin metabolic process (GO:0006768)3.50108724
82peptidyl-glutamic acid carboxylation (GO:0017187)3.47974007
83protein carboxylation (GO:0018214)3.47974007
84regulation of skeletal muscle contraction (GO:0014819)3.47571588
85axoneme assembly (GO:0035082)3.45836923
86acylglycerol homeostasis (GO:0055090)3.43833118
87triglyceride homeostasis (GO:0070328)3.43833118
88mitochondrial respiratory chain complex assembly (GO:0033108)3.40688729
89carnitine metabolic process (GO:0009437)3.39968012
90regulation of acyl-CoA biosynthetic process (GO:0050812)3.37432515
91serine family amino acid metabolic process (GO:0009069)3.36767443
92regulation of cholesterol esterification (GO:0010872)3.36311880
93reverse cholesterol transport (GO:0043691)3.36271223
94cytochrome complex assembly (GO:0017004)3.35517437
95glutamate metabolic process (GO:0006536)3.34419451
96aldehyde catabolic process (GO:0046185)3.33704997
97S-adenosylmethionine metabolic process (GO:0046500)3.32385674
98plasma lipoprotein particle remodeling (GO:0034369)3.29460295
99protein-lipid complex remodeling (GO:0034368)3.29460295
100macromolecular complex remodeling (GO:0034367)3.29460295
101dicarboxylic acid metabolic process (GO:0043648)3.26113297
102cellular biogenic amine catabolic process (GO:0042402)3.25943114
103amine catabolic process (GO:0009310)3.25943114
104phospholipid homeostasis (GO:0055091)3.24718199
105serine family amino acid biosynthetic process (GO:0009070)3.22249310
106regulation of fatty acid oxidation (GO:0046320)3.21944319
107detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21739576
108benzene-containing compound metabolic process (GO:0042537)3.21512345
109pyrimidine nucleoside catabolic process (GO:0046135)3.20190282
110negative regulation of sterol transport (GO:0032372)3.18815649
111negative regulation of cholesterol transport (GO:0032375)3.18815649
112regulation of coenzyme metabolic process (GO:0051196)3.16187102
113regulation of cofactor metabolic process (GO:0051193)3.16187102
114L-fucose catabolic process (GO:0042355)3.15279944
115fucose catabolic process (GO:0019317)3.15279944
116L-fucose metabolic process (GO:0042354)3.15279944
117epithelial cilium movement (GO:0003351)3.14133864
118negative regulation of cytosolic calcium ion concentration (GO:0051481)3.13887753
119DNA deamination (GO:0045006)3.07897049
120mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.07416971
121neuronal action potential (GO:0019228)3.07236304
122L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.07050427
123regulation of fatty acid beta-oxidation (GO:0031998)3.05931272
124L-methionine salvage (GO:0071267)3.05221908
125L-methionine biosynthetic process (GO:0071265)3.05221908
126amino acid salvage (GO:0043102)3.05221908
127positive regulation of fatty acid beta-oxidation (GO:0032000)3.04512643
128mannosylation (GO:0097502)3.03767109
129cofactor catabolic process (GO:0051187)3.03663008
130membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02681874
131indole-containing compound metabolic process (GO:0042430)2.99832072
132water-soluble vitamin biosynthetic process (GO:0042364)2.99352336
133protein-cofactor linkage (GO:0018065)2.96155700
134rRNA catabolic process (GO:0016075)2.94306166
135drug catabolic process (GO:0042737)2.94239714
136exogenous drug catabolic process (GO:0042738)2.93485209
137primary amino compound metabolic process (GO:1901160)2.92912237
138response to pheromone (GO:0019236)2.90308396
139mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82953068
140detection of light stimulus involved in sensory perception (GO:0050962)2.82123703
141detection of light stimulus involved in visual perception (GO:0050908)2.82123703
142cilium or flagellum-dependent cell motility (GO:0001539)2.80262095
143protein polyglutamylation (GO:0018095)2.79656484
144auditory receptor cell stereocilium organization (GO:0060088)2.78072474
145serotonin metabolic process (GO:0042428)2.74529684
146inositol phosphate catabolic process (GO:0071545)2.69390322
147regulation of hexokinase activity (GO:1903299)2.67059322
148regulation of glucokinase activity (GO:0033131)2.67059322
149cilium movement (GO:0003341)2.63973671
150methionine biosynthetic process (GO:0009086)2.62196587
151positive regulation of fatty acid transport (GO:2000193)2.61093746
152preassembly of GPI anchor in ER membrane (GO:0016254)2.60382785
153quinone metabolic process (GO:1901661)2.54137035
154inositol phosphate dephosphorylation (GO:0046855)2.53688833
155phosphorylated carbohydrate dephosphorylation (GO:0046838)2.53688833
156adenosine metabolic process (GO:0046085)2.53428195
157regulation of relaxation of muscle (GO:1901077)2.52789685
158dopamine transport (GO:0015872)2.50568462
159regulation of rhodopsin mediated signaling pathway (GO:0022400)2.50421940
160membrane depolarization during action potential (GO:0086010)2.49343656
161NAD biosynthetic process (GO:0009435)2.49136835
162regulation of cilium movement (GO:0003352)2.48083250
163positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.47432482
164photoreceptor cell maintenance (GO:0045494)2.46934206
165rhodopsin mediated signaling pathway (GO:0016056)2.45100238
166retinal cone cell development (GO:0046549)2.44883845
167positive regulation of sodium ion transmembrane transport (GO:1902307)2.43590568
168regulation of action potential (GO:0098900)2.41477289
169action potential (GO:0001508)2.41039782
170oxidative demethylation (GO:0070989)2.40311453
171synaptic transmission, cholinergic (GO:0007271)2.37902353
172alkaloid metabolic process (GO:0009820)2.37360198
173protein K11-linked deubiquitination (GO:0035871)2.37208344
174polyol catabolic process (GO:0046174)2.36620487
175gamma-aminobutyric acid transport (GO:0015812)2.36129594
176electron transport chain (GO:0022900)2.36027311
177arginine metabolic process (GO:0006525)2.35758168
178regulation of mitotic spindle checkpoint (GO:1903504)2.35251161
179regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.35251161
180behavioral response to ethanol (GO:0048149)2.34318115
181estrogen biosynthetic process (GO:0006703)2.33202963
182thyroid hormone metabolic process (GO:0042403)2.31980603
183base-excision repair, AP site formation (GO:0006285)2.31770838
184neuronal action potential propagation (GO:0019227)2.31675520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.38357021
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.29312312
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.13784664
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.56436856
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.78344628
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.62765292
7LXR_22158963_ChIP-Seq_LIVER_Mouse4.48418694
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.29996870
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.69442264
10ZNF274_21170338_ChIP-Seq_K562_Hela3.52265289
11IGF1R_20145208_ChIP-Seq_DFB_Human3.20443342
12VDR_22108803_ChIP-Seq_LS180_Human3.10090234
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.03486901
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.98871776
15GBX2_23144817_ChIP-Seq_PC3_Human2.93313940
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.85593511
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79524764
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72664672
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37610280
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.28136152
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28134584
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26175305
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.24758819
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.21322803
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16237769
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.16033473
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13514067
28GATA1_22025678_ChIP-Seq_K562_Human2.08440117
29FUS_26573619_Chip-Seq_HEK293_Human2.03969844
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01405403
31TAF15_26573619_Chip-Seq_HEK293_Human1.99882119
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98171586
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93837238
34ER_23166858_ChIP-Seq_MCF-7_Human1.92346148
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87344131
36EWS_26573619_Chip-Seq_HEK293_Human1.85604986
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84604652
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.80954956
39* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76416219
40P300_19829295_ChIP-Seq_ESCs_Human1.75663921
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.74901419
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73466210
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65078254
44IRF1_19129219_ChIP-ChIP_H3396_Human1.62265488
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60218308
46FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58964087
47TP53_22573176_ChIP-Seq_HFKS_Human1.55495527
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50219778
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.45463834
50CBP_20019798_ChIP-Seq_JUKART_Human1.45381185
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45381185
52BCAT_22108803_ChIP-Seq_LS180_Human1.44957342
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43017101
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42465650
55* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.40209501
56FOXP3_21729870_ChIP-Seq_TREG_Human1.39874398
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39486824
58MYC_18940864_ChIP-ChIP_HL60_Human1.39081385
59TCF4_23295773_ChIP-Seq_U87_Human1.38539426
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.38399132
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37922963
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.37922963
63* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36988092
64* SOX2_19829295_ChIP-Seq_ESCs_Human1.36922894
65* NANOG_19829295_ChIP-Seq_ESCs_Human1.36922894
66CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35501512
67HTT_18923047_ChIP-ChIP_STHdh_Human1.35379203
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34863395
69SMAD4_21799915_ChIP-Seq_A2780_Human1.34837885
70* STAT3_23295773_ChIP-Seq_U87_Human1.34455530
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33120348
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32479200
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31796150
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.30171395
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30079289
76AR_25329375_ChIP-Seq_VCAP_Human1.29628925
77ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29297028
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.28669496
79REST_21632747_ChIP-Seq_MESCs_Mouse1.27630619
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26254403
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24833703
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.24806479
83* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24739405
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24719659
85* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23785322
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.22266907
87NCOR_22424771_ChIP-Seq_293T_Human1.22063560
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21166431
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20660251
90RUNX2_22187159_ChIP-Seq_PCA_Human1.20289793
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19508446
92THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19424770
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.19080050
94TCF4_22108803_ChIP-Seq_LS180_Human1.18983291
95AR_21572438_ChIP-Seq_LNCaP_Human1.18882902
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18531201
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18531201
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18192933
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17667004
100CLOCK_20551151_ChIP-Seq_293T_Human1.16874334
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15934458
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.15699304
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15574501
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14226351
105ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13868141
106HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13820696
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13765907
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11599251
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11130372
110RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09757573
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.09172035
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.08542308
113* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08020750
114CIITA_25753668_ChIP-Seq_RAJI_Human1.07001461
115DCP1A_22483619_ChIP-Seq_HELA_Human1.06874613
116* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06443716
117CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06290961
118GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05380255
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04993746
120* GABP_19822575_ChIP-Seq_HepG2_Human1.04198321
121SMAD4_21741376_ChIP-Seq_EPCs_Human1.03346580
122YY1_21170310_ChIP-Seq_MESCs_Mouse1.02596997
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02477726
124MYC_19829295_ChIP-Seq_ESCs_Human1.02095921
125HOXB7_26014856_ChIP-Seq_BT474_Human1.01972415
126ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01354532
127STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01006991
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00353622
129ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00332865
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00258629
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99808344
132CRX_20693478_ChIP-Seq_RETINA_Mouse0.99098870
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97809994
134RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97778885
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96916936
136RNF2_27304074_Chip-Seq_NSC_Mouse0.96488430
137FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96154272
138IRF8_22096565_ChIP-ChIP_GC-B_Human0.96002446
139* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95205705
140NANOG_20526341_ChIP-Seq_ESCs_Human0.95152506
141OCT4_20526341_ChIP-Seq_ESCs_Human0.95073032
142CBX2_27304074_Chip-Seq_ESCs_Mouse0.94884898
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.94862004
144P53_22387025_ChIP-Seq_ESCs_Mouse0.94692802
145CDX2_22108803_ChIP-Seq_LS180_Human0.94508835
146ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94407567
147* HNF4A_19822575_ChIP-Seq_HepG2_Human0.93820303
148AR_20517297_ChIP-Seq_VCAP_Human0.92642681
149CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89385931
150SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88564998
151TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88537960
152CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88517608
153HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86775071
154CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83959708
155SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.83572293
156EZH2_22144423_ChIP-Seq_EOC_Human0.81923096
157MYC_18555785_ChIP-Seq_MESCs_Mouse0.78483819
158SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78189978
159ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76653042
160ERG_20517297_ChIP-Seq_VCAP_Human0.76457631
161TBX20_22328084_ChIP-Seq_HEART_Mouse0.72363957
162TBX20_22080862_ChIP-Seq_HEART_Mouse0.72363957
163RARA_24833708_ChIP-Seq_LIVER_Mouse0.71361181
164* VDR_23849224_ChIP-Seq_CD4+_Human0.70459709
165* FOXA2_19822575_ChIP-Seq_HepG2_Human0.70337149
166NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69242179
167RARG_19884340_ChIP-ChIP_MEFs_Mouse0.68419383
168CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.68050338
169GATA1_19941827_ChIP-Seq_MEL_Mouse0.67737274
170MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.67666041
171NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.67412290
172TET1_21451524_ChIP-Seq_MESCs_Mouse0.66770943
173NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66337957
174MYC_19030024_ChIP-ChIP_MESCs_Mouse0.66106827
175AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66103642
176TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.65568190
177STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.65192107
178TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.63760974
179BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63585810
180RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.62479111
181LXR_22292898_ChIP-Seq_THP-1_Human0.62406624
182CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.62328152
183* BCL6_27268052_Chip-Seq_Bcells_Human0.61959861
184* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60887815
185NELFA_20434984_ChIP-Seq_ESCs_Mouse0.60401352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.47313406
2MP0005360_urolithiasis5.58429499
3MP0005365_abnormal_bile_salt5.42031081
4MP0003806_abnormal_nucleotide_metabolis5.02685256
5MP0005085_abnormal_gallbladder_physiolo5.00281844
6MP0002837_dystrophic_cardiac_calcinosis4.39414254
7MP0008875_abnormal_xenobiotic_pharmacok3.66532689
8MP0003646_muscle_fatigue3.41322237
9MP0010329_abnormal_lipoprotein_level2.94563273
10MP0003252_abnormal_bile_duct2.74710275
11MP0004084_abnormal_cardiac_muscle2.63509072
12MP0005332_abnormal_amino_acid2.52363121
13MP0006036_abnormal_mitochondrial_physio2.41791060
14MP0005083_abnormal_biliary_tract2.41733047
15MP0001968_abnormal_touch/_nociception2.37666714
16MP0009840_abnormal_foam_cell2.37293831
17MP0004043_abnormal_pH_regulation2.35030626
18MP0002638_abnormal_pupillary_reflex2.33851387
19MP0004215_abnormal_myocardial_fiber2.18885448
20MP0005551_abnormal_eye_electrophysiolog2.18348754
21MP0009697_abnormal_copulation2.17985409
22MP0004036_abnormal_muscle_relaxation2.13143731
23MP0005645_abnormal_hypothalamus_physiol2.09160185
24MP0008877_abnormal_DNA_methylation2.08228734
25MP0006035_abnormal_mitochondrial_morpho2.07931370
26MP0009046_muscle_twitch2.01983472
27MP0001666_abnormal_nutrient_absorption2.01773041
28MP0004130_abnormal_muscle_cell2.01678775
29MP0005319_abnormal_enzyme/_coenzyme2.00215217
30MP0000751_myopathy1.94989689
31MP0001986_abnormal_taste_sensitivity1.92131409
32MP0003191_abnormal_cellular_cholesterol1.91099450
33MP0003195_calcinosis1.87483992
34MP0008872_abnormal_physiological_respon1.86423455
35MP0002118_abnormal_lipid_homeostasis1.79699630
36MP0003880_abnormal_central_pattern1.77034812
37MP0005330_cardiomyopathy1.76494924
38MP0000609_abnormal_liver_physiology1.74718559
39MP0006072_abnormal_retinal_apoptosis1.73786875
40MP0009745_abnormal_behavioral_response1.72472993
41MP0006292_abnormal_olfactory_placode1.70355805
42MP0002102_abnormal_ear_morphology1.66659113
43MP0001984_abnormal_olfaction1.64999652
44MP0005584_abnormal_enzyme/coenzyme_acti1.64117966
45MP0001764_abnormal_homeostasis1.61486997
46MP0002272_abnormal_nervous_system1.61419162
47MP0000569_abnormal_digit_pigmentation1.61183780
48MP0004142_abnormal_muscle_tone1.60034671
49MP0002736_abnormal_nociception_after1.58287423
50MP0003787_abnormal_imprinting1.57950984
51MP0005253_abnormal_eye_physiology1.56489273
52MP0010386_abnormal_urinary_bladder1.55699154
53MP0006276_abnormal_autonomic_nervous1.55535866
54MP0000749_muscle_degeneration1.45023478
55MP0003868_abnormal_feces_composition1.43840188
56MP0005266_abnormal_metabolism1.42391552
57MP0000372_irregular_coat_pigmentation1.38122917
58MP0003186_abnormal_redox_activity1.35182672
59MP0004133_heterotaxia1.34980194
60MP0002972_abnormal_cardiac_muscle1.33082277
61MP0002234_abnormal_pharynx_morphology1.30450395
62MP0002269_muscular_atrophy1.28108312
63MP0003137_abnormal_impulse_conducting1.27791176
64MP0001486_abnormal_startle_reflex1.27577948
65MP0010368_abnormal_lymphatic_system1.26579655
66MP0002064_seizures1.25797148
67MP0005385_cardiovascular_system_phenoty1.23231551
68MP0001544_abnormal_cardiovascular_syste1.23231551
69MP0003136_yellow_coat_color1.18124012
70MP0002078_abnormal_glucose_homeostasis1.16628796
71MP0005167_abnormal_blood-brain_barrier1.14150529
72MP0000631_abnormal_neuroendocrine_gland1.13850318
73MP0005451_abnormal_body_composition1.13554964
74MP0005620_abnormal_muscle_contractility1.13078905
75MP0001485_abnormal_pinna_reflex1.11944744
76MP0003221_abnormal_cardiomyocyte_apopto1.11847183
77MP0001501_abnormal_sleep_pattern1.10698722
78MP0009643_abnormal_urine_homeostasis1.09953347
79MP0004087_abnormal_muscle_fiber1.07626263
80MP0002572_abnormal_emotion/affect_behav1.05258968
81MP0002733_abnormal_thermal_nociception1.04802368
82MP0000598_abnormal_liver_morphology1.03772094
83MP0002160_abnormal_reproductive_system1.02945206
84MP0008775_abnormal_heart_ventricle1.01602625
85MP0000427_abnormal_hair_cycle1.00759146
86MP0005174_abnormal_tail_pigmentation0.99391626
87MP0003656_abnormal_erythrocyte_physiolo0.99132809
88MP0005423_abnormal_somatic_nervous0.98889938
89MP0004019_abnormal_vitamin_homeostasis0.97510477
90MP0008995_early_reproductive_senescence0.97098157
91MP0002138_abnormal_hepatobiliary_system0.96252391
92MP0005376_homeostasis/metabolism_phenot0.95825251
93MP0002127_abnormal_cardiovascular_syste0.94779387
94MP0004924_abnormal_behavior0.94124927
95MP0005386_behavior/neurological_phenoty0.94124927
96MP0004085_abnormal_heartbeat0.93327409
97MP0010630_abnormal_cardiac_muscle0.93262017
98MP0001905_abnormal_dopamine_level0.92800646
99MP0001970_abnormal_pain_threshold0.92572575
100MP0005670_abnormal_white_adipose0.92177430
101MP0002067_abnormal_sensory_capabilities0.92010924
102MP0008058_abnormal_DNA_repair0.90771680
103MP0003635_abnormal_synaptic_transmissio0.90182756
104MP0009763_increased_sensitivity_to0.90157120
105MP0006138_congestive_heart_failure0.89779145
106MP0002938_white_spotting0.89675748
107MP0003718_maternal_effect0.89455058
108MP0004885_abnormal_endolymph0.89432312
109MP0002332_abnormal_exercise_endurance0.88854486
110MP0002735_abnormal_chemical_nociception0.88442822
111MP0002876_abnormal_thyroid_physiology0.88240354
112MP0005084_abnormal_gallbladder_morpholo0.87695921
113MP0004147_increased_porphyrin_level0.86916136
114MP0005389_reproductive_system_phenotype0.86588133
115MP0002557_abnormal_social/conspecific_i0.86504532
116MP0002229_neurodegeneration0.85175145
117MP0000013_abnormal_adipose_tissue0.84513714
118MP0005535_abnormal_body_temperature0.84491479
119MP0009642_abnormal_blood_homeostasis0.84275696
120MP0005636_abnormal_mineral_homeostasis0.82994851
121MP0002063_abnormal_learning/memory/cond0.82331810
122MP0002928_abnormal_bile_duct0.82135913
123MP0002734_abnormal_mechanical_nocicepti0.81096256
124MP0002396_abnormal_hematopoietic_system0.80555206
125MP0004484_altered_response_of0.79731152
126MP0005075_abnormal_melanosome_morpholog0.79687416
127MP0005220_abnormal_exocrine_pancreas0.78654234
128MP0002106_abnormal_muscle_physiology0.78417079
129MP0001529_abnormal_vocalization0.78140680
130MP0000747_muscle_weakness0.77171120
131MP0003698_abnormal_male_reproductive0.76956572
132MP0003567_abnormal_fetal_cardiomyocyte0.76703575
133MP0000230_abnormal_systemic_arterial0.70807721
134MP0008874_decreased_physiological_sensi0.69866567
135MP0008469_abnormal_protein_level0.69520720
136MP0005666_abnormal_adipose_tissue0.69289243
137MP0005165_increased_susceptibility_to0.69252181
138MP0005646_abnormal_pituitary_gland0.62270913
139MP0005448_abnormal_energy_balance0.60565182
140MP0000358_abnormal_cell_content/0.60094842
141MP0003953_abnormal_hormone_level0.59037711
142MP0003011_delayed_dark_adaptation0.59024716
143MP0005334_abnormal_fat_pad0.59023636
144MP0000604_amyloidosis0.58853294
145MP0003329_amyloid_beta_deposits0.57595774
146MP0005369_muscle_phenotype0.57540851
147MP0003879_abnormal_hair_cell0.56890558
148MP0002971_abnormal_brown_adipose0.55139125
149MP0005595_abnormal_vascular_smooth0.53130182
150MP0000750_abnormal_muscle_regeneration0.52085537
151MP0000759_abnormal_skeletal_muscle0.48441629
152MP0001756_abnormal_urination0.46952956
153MP0005647_abnormal_sex_gland0.43202585
154MP0009764_decreased_sensitivity_to0.42796453
155MP0004145_abnormal_muscle_electrophysio0.40498367
156MP0002909_abnormal_adrenal_gland0.38563958
157MP0001853_heart_inflammation0.37498079
158MP0005464_abnormal_platelet_physiology0.37364769
159MP0002970_abnormal_white_adipose0.35870969
160MP0009672_abnormal_birth_weight0.35793718
161MP0001661_extended_life_span0.35407663
162MP0000343_altered_response_to0.34909737

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.01697908
2Deep venous thrombosis (HP:0002625)4.45098906
3Ketosis (HP:0001946)4.40375900
4Pancreatic cysts (HP:0001737)4.37952250
5Hypobetalipoproteinemia (HP:0003563)4.36390283
6Ketoacidosis (HP:0001993)4.36187093
7Abnormality of fatty-acid metabolism (HP:0004359)4.27462808
8Hyperammonemia (HP:0001987)4.25223668
9Abnormality of long-chain fatty-acid metabolism (HP:0010964)4.17934156
10Intrahepatic cholestasis (HP:0001406)4.03025026
11Ragged-red muscle fibers (HP:0003200)3.99182797
12Hypoglycemic coma (HP:0001325)3.96613647
13Hyperglycinuria (HP:0003108)3.88225029
14Abnormality of dicarboxylic acid metabolism (HP:0010995)3.85306637
15Dicarboxylic aciduria (HP:0003215)3.85306637
16Pancreatic fibrosis (HP:0100732)3.82024676
17Increased serum pyruvate (HP:0003542)3.80055111
18Abnormality of glycolysis (HP:0004366)3.80055111
19Prolonged partial thromboplastin time (HP:0003645)3.78993301
20Hepatic necrosis (HP:0002605)3.68452160
21Xanthomatosis (HP:0000991)3.61678064
22Congenital stationary night blindness (HP:0007642)3.61250843
23True hermaphroditism (HP:0010459)3.57143945
24Abnormality of monocarboxylic acid metabolism (HP:0010996)3.56454242
25Abnormality of midbrain morphology (HP:0002418)3.54942605
26Molar tooth sign on MRI (HP:0002419)3.54942605
27Hyperlipoproteinemia (HP:0010980)3.54877130
28Cerebral edema (HP:0002181)3.51221018
29Abnormality of serine family amino acid metabolism (HP:0010894)3.45959811
30Abnormality of glycine metabolism (HP:0010895)3.45959811
31Nephronophthisis (HP:0000090)3.36811573
32Hyperglycinemia (HP:0002154)3.34371458
33Palpitations (HP:0001962)3.32568750
34Acute encephalopathy (HP:0006846)3.25319920
35Metabolic acidosis (HP:0001942)3.23782361
36Hypolipoproteinemia (HP:0010981)3.18642063
37Myoglobinuria (HP:0002913)3.18629614
38Hepatocellular necrosis (HP:0001404)3.15889651
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14382559
40Abnormality of alanine metabolism (HP:0010916)3.14382559
41Hyperalaninemia (HP:0003348)3.14382559
42Abnormal mitochondria in muscle tissue (HP:0008316)3.10403005
43Lethargy (HP:0001254)3.10372437
44Abnormality of serum amino acid levels (HP:0003112)3.04108573
45Abnormality of the renal cortex (HP:0011035)3.03217629
46Lactic acidosis (HP:0003128)2.99460649
47Delayed CNS myelination (HP:0002188)2.94650104
48Generalized aminoaciduria (HP:0002909)2.93758720
49Type II lissencephaly (HP:0007260)2.92222641
50Acute necrotizing encephalopathy (HP:0006965)2.91577656
51Abnormality of methionine metabolism (HP:0010901)2.89072254
52Abnormality of the renal medulla (HP:0100957)2.85804099
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.84129683
54Hyperbilirubinemia (HP:0002904)2.80485115
55Cystic liver disease (HP:0006706)2.79411137
56Complement deficiency (HP:0004431)2.77445032
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76240842
58Abnormality of the intrinsic pathway (HP:0010989)2.74968613
59Increased CSF lactate (HP:0002490)2.69565780
60Abnormal drinking behavior (HP:0030082)2.67989793
61Polydipsia (HP:0001959)2.67989793
62Abnormal biliary tract physiology (HP:0012439)2.66399877
63Bile duct proliferation (HP:0001408)2.66399877
64Rhabdomyolysis (HP:0003201)2.64388167
65Hypoalphalipoproteinemia (HP:0003233)2.64187030
66Fair hair (HP:0002286)2.62575725
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.59940069
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.59940069
69Abnormality of sulfur amino acid metabolism (HP:0004339)2.55690192
70Congenital, generalized hypertrichosis (HP:0004540)2.54450443
71Lipid accumulation in hepatocytes (HP:0006561)2.54378157
72Gout (HP:0001997)2.53304857
73Chronic hepatic failure (HP:0100626)2.52804479
74Vomiting (HP:0002013)2.50263273
75Increased muscle lipid content (HP:0009058)2.50150407
76Attenuation of retinal blood vessels (HP:0007843)2.49900953
77Mitochondrial inheritance (HP:0001427)2.49592918
78Medial flaring of the eyebrow (HP:0010747)2.48192845
79Exercise-induced myalgia (HP:0003738)2.47655163
80Sudden death (HP:0001699)2.46470167
81Fat malabsorption (HP:0002630)2.46275683
82Epidermoid cyst (HP:0200040)2.45519718
83Joint hemorrhage (HP:0005261)2.44483149
84Increased serum lactate (HP:0002151)2.42743402
85Tubular atrophy (HP:0000092)2.42146281
86Absent/shortened dynein arms (HP:0200106)2.39499873
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.39499873
88Hyperinsulinemic hypoglycemia (HP:0000825)2.37132260
89Gaze-evoked nystagmus (HP:0000640)2.36836172
90Ventricular tachycardia (HP:0004756)2.36772462
91Abolished electroretinogram (ERG) (HP:0000550)2.35224297
92Cholelithiasis (HP:0001081)2.34179524
93Abnormality of the common coagulation pathway (HP:0010990)2.33902738
94Microvesicular hepatic steatosis (HP:0001414)2.33607902
95Renal cortical cysts (HP:0000803)2.32160432
96Progressive macrocephaly (HP:0004481)2.30705854
97Congenital hepatic fibrosis (HP:0002612)2.30048486
98Increased hepatocellular lipid droplets (HP:0006565)2.29089368
99Late onset (HP:0003584)2.28529791
100Abnormal rod and cone electroretinograms (HP:0008323)2.27016081
101Abnormal gallbladder morphology (HP:0012437)2.26470962
102Methylmalonic acidemia (HP:0002912)2.24818385
103Abnormality of glutamine family amino acid metabolism (HP:0010902)2.23883476
104Acute hepatic failure (HP:0006554)2.22174880
105Muscle hypertrophy of the lower extremities (HP:0008968)2.20719008
106Calf muscle hypertrophy (HP:0008981)2.20154029
107Methylmalonic aciduria (HP:0012120)2.18886139
108Abnormal respiratory epithelium morphology (HP:0012253)2.18349828
109Abnormal respiratory motile cilium morphology (HP:0005938)2.18349828
110Right ventricular cardiomyopathy (HP:0011663)2.17101572
111Sclerocornea (HP:0000647)2.14037683
112Cholecystitis (HP:0001082)2.13796495
113Abnormal gallbladder physiology (HP:0012438)2.13796495
114Decreased central vision (HP:0007663)2.11686279
115Decreased electroretinogram (ERG) amplitude (HP:0000654)2.11439054
116Neoplasm of the adrenal gland (HP:0100631)2.09578748
117Hypothermia (HP:0002045)2.09189791
118Pheochromocytoma (HP:0002666)2.08503105
119Inability to walk (HP:0002540)2.06995907
120Lipoatrophy (HP:0100578)2.06457619
121Increased intramyocellular lipid droplets (HP:0012240)2.05799111
122Muscle fiber inclusion bodies (HP:0100299)2.02634793
123Skin nodule (HP:0200036)2.02219909
124Broad-based gait (HP:0002136)2.02137710
125Exercise-induced muscle cramps (HP:0003710)2.01801344
126Furrowed tongue (HP:0000221)2.01729228
127Sensorimotor neuropathy (HP:0007141)2.01392907
128Conjugated hyperbilirubinemia (HP:0002908)2.01250783
129Steatorrhea (HP:0002570)2.00624888
130Optic disc pallor (HP:0000543)1.99499654
131Febrile seizures (HP:0002373)1.99148436
132Atrial fibrillation (HP:0005110)1.98896484
133Polyuria (HP:0000103)1.98236885
134Pendular nystagmus (HP:0012043)1.96391807
135Abnormality of urine glucose concentration (HP:0011016)1.96332568
136Glycosuria (HP:0003076)1.96332568
137CNS demyelination (HP:0007305)1.95534193
138Abnormality of pyrimidine metabolism (HP:0004353)1.94929353
139Hyperventilation (HP:0002883)1.94273478
140Nemaline bodies (HP:0003798)1.93541727
141Dilated cardiomyopathy (HP:0001644)1.92981992
142Hypoglycemic seizures (HP:0002173)1.92931987
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.92887595
144Abnormality of nucleobase metabolism (HP:0010932)1.92845501
145Abnormality of secondary sexual hair (HP:0009888)1.92356754
146Abnormality of the axillary hair (HP:0100134)1.92356754
147Generalized hypopigmentation of hair (HP:0011358)1.92231590
148Abnormality of complement system (HP:0005339)1.92106737
149Abnormality of purine metabolism (HP:0004352)1.91803575
150Pancreatic islet-cell hyperplasia (HP:0004510)1.90924700
151Neuroendocrine neoplasm (HP:0100634)1.90892785
152Supraventricular tachycardia (HP:0004755)1.90720779
153Focal motor seizures (HP:0011153)1.90080906
154Male pseudohermaphroditism (HP:0000037)1.89901814
155Abnormal ciliary motility (HP:0012262)1.89869952
156Cerebellar dysplasia (HP:0007033)1.89706619
157Asymmetric septal hypertrophy (HP:0001670)1.89611343
158Lissencephaly (HP:0001339)1.88173595
159Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.87433513
1603-Methylglutaconic aciduria (HP:0003535)1.86014316
161Progressive inability to walk (HP:0002505)1.83039088
162Gait imbalance (HP:0002141)1.82637067
163Progressive cerebellar ataxia (HP:0002073)1.81140880
164Dry hair (HP:0011359)1.80622993
165Stomach cancer (HP:0012126)1.79556781
166Severe muscular hypotonia (HP:0006829)1.77164650
167Decreased circulating renin level (HP:0003351)1.76474574
168Bundle branch block (HP:0011710)1.74990801
169Congenital primary aphakia (HP:0007707)1.74338793
170Type I transferrin isoform profile (HP:0003642)1.73302853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.40350428
2BCKDK5.12440011
3FLT33.97739356
4PIK3CG3.01871125
5PDK32.78840184
6PDK42.78840184
7ZAK2.63871855
8BMPR1B2.60667832
9PKN22.45366148
10MYLK2.44096440
11ADRBK22.41835139
12NUAK12.41796329
13WNK32.30172127
14NEK12.24067161
15CCNB12.12476987
16FGFR42.09985188
17GRK12.09219955
18MAP4K22.08699925
19ERN12.08535990
20TLK12.08141694
21TXK1.97769125
22PINK11.97712899
23PHKG21.96100602
24PHKG11.96100602
25KIT1.92626441
26SIK31.89837286
27SIK11.89327739
28MAP3K121.83467143
29WNK41.77232206
30EPHA31.76075076
31MAPK131.73797031
32TRIB31.69672344
33MAP2K71.68261795
34TAOK21.67628870
35MAP2K41.67141352
36STK161.63590332
37MAPKAPK31.61914809
38OXSR11.61400233
39TTN1.59049699
40INSRR1.58421133
41DAPK11.47682549
42LMTK21.46654629
43NTRK31.39205520
44KDR1.37731462
45ARAF1.36213332
46EIF2AK11.31496317
47OBSCN1.29894043
48TAOK31.20873453
49EPHA41.14376074
50TIE11.12096960
51TGFBR11.12037772
52PLK21.10381437
53BRSK21.08146382
54MUSK1.07223559
55PDK21.06332700
56STK391.05476210
57PRPF4B1.04920403
58MAPK111.04095650
59CSF1R1.04024234
60VRK20.99239472
61KSR10.99052992
62ADRBK10.98654470
63MAP3K40.97579476
64MKNK20.91466015
65BRAF0.90853355
66FGFR20.87866568
67MAP3K70.87499569
68FES0.87293557
69MARK10.85514734
70MAP3K130.84661004
71PRKCE0.83992359
72MST40.81783755
73ACVR1B0.80915905
74ERBB30.80819531
75CSNK1G30.80383252
76MAPK40.80011895
77EEF2K0.79896737
78MAPK120.79611875
79CSNK1G20.79496532
80NEK90.78275633
81MAP3K110.77304647
82CSNK1A1L0.76659222
83MAP2K30.76367005
84CDK190.76128837
85GRK60.75835430
86VRK10.74230619
87CSNK1G10.73564569
88TYK20.73214119
89PAK30.73170965
90PRKCQ0.72158278
91NEK20.68124449
92SGK20.66302412
93SIK20.65881175
94NME10.65684094
95MAPKAPK50.65053514
96TNK20.64876540
97CAMK2A0.63593527
98WEE10.63069266
99TEC0.62722213
100MAP3K50.62531521
101PIK3CA0.61418717
102TNIK0.60342474
103ITK0.59745079
104BRSK10.57608941
105TRIM280.57556408
106RAF10.56765369
107MAP3K60.56441601
108STK38L0.55949604
109PLK40.55671380
110NME20.54598856
111MAPK150.53942342
112RPS6KA50.53729570
113EIF2AK30.53635941
114DYRK20.53331597
115CAMK2D0.52848151
116STK110.51942204
117STK240.50496443
118PTK2B0.50349161
119PRKCG0.49553327
120PRKAA10.49201335
121ABL20.49054667
122GRK50.48312948
123PRKAA20.48220795
124CAMK2G0.47102443
125MKNK10.45323708
126PRKACG0.45111828
127ZAP700.44256599
128GRK70.43885440
129RPS6KB10.42806541
130SGK30.42773392
131SYK0.42452624
132PRKG10.42117589
133DAPK20.41902534
134CAMKK20.41557977
135IKBKB0.41195537
136CSNK1D0.40990925
137AKT30.40551535
138PKN10.40221547
139MAP2K60.40164232
140JAK30.39576882
141CDK30.37550141
142PRKCA0.37549051
143CAMK40.34763823
144NTRK20.34045015
145ERBB40.34017873
146CSNK1A10.33897427
147ATR0.33225209
148DYRK1A0.32276344
149MAP2K10.31971130
150PRKCI0.31669525
151KSR20.30669392
152IGF1R0.30424010
153PRKCZ0.29953739
154CASK0.29128335
155FER0.28600709
156CAMK10.28587795
157TSSK60.26999030
158PRKACA0.26761275
159MAPK70.25968725
160RIPK10.25892868

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.90339262
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.81069202
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.47883719
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.35308218
5Fatty acid degradation_Homo sapiens_hsa000713.11638963
6Propanoate metabolism_Homo sapiens_hsa006403.01257051
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.99497978
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.94775430
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.46934481
10Tryptophan metabolism_Homo sapiens_hsa003802.46184322
11Linoleic acid metabolism_Homo sapiens_hsa005912.42455802
12Pyruvate metabolism_Homo sapiens_hsa006202.42217648
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41808359
14Fatty acid metabolism_Homo sapiens_hsa012122.31045389
15Butanoate metabolism_Homo sapiens_hsa006502.30518330
16Carbon metabolism_Homo sapiens_hsa012002.27426417
17Phototransduction_Homo sapiens_hsa047442.25613124
18Arginine biosynthesis_Homo sapiens_hsa002202.25433770
19Peroxisome_Homo sapiens_hsa041462.10619417
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03426751
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98841845
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97140378
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84355164
24Biosynthesis of amino acids_Homo sapiens_hsa012301.77286804
25Complement and coagulation cascades_Homo sapiens_hsa046101.72631543
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70456798
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67479014
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.67209122
29beta-Alanine metabolism_Homo sapiens_hsa004101.65483193
30Selenocompound metabolism_Homo sapiens_hsa004501.60131928
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.59078126
32Homologous recombination_Homo sapiens_hsa034401.57762084
33PPAR signaling pathway_Homo sapiens_hsa033201.57569828
34Nicotine addiction_Homo sapiens_hsa050331.54764865
35Nitrogen metabolism_Homo sapiens_hsa009101.50482428
36Sulfur metabolism_Homo sapiens_hsa009201.46602411
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43288770
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39704567
39Fanconi anemia pathway_Homo sapiens_hsa034601.35180546
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34685686
41Fatty acid elongation_Homo sapiens_hsa000621.30166336
42Phenylalanine metabolism_Homo sapiens_hsa003601.28469129
43Ether lipid metabolism_Homo sapiens_hsa005651.27707249
44Chemical carcinogenesis_Homo sapiens_hsa052041.26012039
45Parkinsons disease_Homo sapiens_hsa050121.25835807
46Oxidative phosphorylation_Homo sapiens_hsa001901.24710844
47RNA polymerase_Homo sapiens_hsa030201.23906557
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.23081268
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22080271
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22062865
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20239649
52Starch and sucrose metabolism_Homo sapiens_hsa005001.20232251
53Olfactory transduction_Homo sapiens_hsa047401.19864611
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16510126
55Arachidonic acid metabolism_Homo sapiens_hsa005901.15368987
56Folate biosynthesis_Homo sapiens_hsa007901.14339498
57Taste transduction_Homo sapiens_hsa047421.12834413
58Tyrosine metabolism_Homo sapiens_hsa003501.10345759
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09343846
60Basal transcription factors_Homo sapiens_hsa030221.04718250
61Asthma_Homo sapiens_hsa053101.03578529
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.03188026
63Histidine metabolism_Homo sapiens_hsa003401.00762866
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00338918
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98186034
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96878246
67RNA degradation_Homo sapiens_hsa030180.95145199
68Sulfur relay system_Homo sapiens_hsa041220.94677037
69Protein export_Homo sapiens_hsa030600.88247617
70Morphine addiction_Homo sapiens_hsa050320.87375375
71Bile secretion_Homo sapiens_hsa049760.87345463
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87245055
73Retinol metabolism_Homo sapiens_hsa008300.86445790
74Arginine and proline metabolism_Homo sapiens_hsa003300.86197764
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.84995990
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84586409
77Non-homologous end-joining_Homo sapiens_hsa034500.82583953
78ABC transporters_Homo sapiens_hsa020100.79988650
79Circadian entrainment_Homo sapiens_hsa047130.79595252
80Calcium signaling pathway_Homo sapiens_hsa040200.78197945
81Pentose phosphate pathway_Homo sapiens_hsa000300.77597279
82Alzheimers disease_Homo sapiens_hsa050100.75147664
83Cardiac muscle contraction_Homo sapiens_hsa042600.73947872
84Insulin secretion_Homo sapiens_hsa049110.73649282
85Primary immunodeficiency_Homo sapiens_hsa053400.73647383
86Fructose and mannose metabolism_Homo sapiens_hsa000510.72241612
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.71225424
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70813671
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70207466
90Vitamin B6 metabolism_Homo sapiens_hsa007500.68376503
91Metabolic pathways_Homo sapiens_hsa011000.67938575
92Fat digestion and absorption_Homo sapiens_hsa049750.67807768
93Serotonergic synapse_Homo sapiens_hsa047260.67716157
94Caffeine metabolism_Homo sapiens_hsa002320.67447058
95Galactose metabolism_Homo sapiens_hsa000520.66497657
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63969774
97GABAergic synapse_Homo sapiens_hsa047270.63697646
98Glutamatergic synapse_Homo sapiens_hsa047240.61643822
99Salivary secretion_Homo sapiens_hsa049700.61244630
100Ovarian steroidogenesis_Homo sapiens_hsa049130.59134656
101Staphylococcus aureus infection_Homo sapiens_hsa051500.58668834
102One carbon pool by folate_Homo sapiens_hsa006700.58150834
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53244280
104Huntingtons disease_Homo sapiens_hsa050160.52954113
105Glycerolipid metabolism_Homo sapiens_hsa005610.51757041
106Lysine degradation_Homo sapiens_hsa003100.51609595
107Type I diabetes mellitus_Homo sapiens_hsa049400.51040415
108Renin secretion_Homo sapiens_hsa049240.49216057
109Oxytocin signaling pathway_Homo sapiens_hsa049210.46645447
110Glutathione metabolism_Homo sapiens_hsa004800.45771860
111Fatty acid biosynthesis_Homo sapiens_hsa000610.43141352
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42986155
113Glucagon signaling pathway_Homo sapiens_hsa049220.41314713
114Proteasome_Homo sapiens_hsa030500.40162815
115Graft-versus-host disease_Homo sapiens_hsa053320.39767429
116Autoimmune thyroid disease_Homo sapiens_hsa053200.39045836
117Insulin resistance_Homo sapiens_hsa049310.39020563
118Allograft rejection_Homo sapiens_hsa053300.38911180
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.38161684
120Vitamin digestion and absorption_Homo sapiens_hsa049770.35574595
121Pyrimidine metabolism_Homo sapiens_hsa002400.31273322
122DNA replication_Homo sapiens_hsa030300.23467044
123Regulation of autophagy_Homo sapiens_hsa041400.20748564
124Insulin signaling pathway_Homo sapiens_hsa049100.19051329
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.18308046
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17107898
127Dilated cardiomyopathy_Homo sapiens_hsa054140.15812426
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.13223129
129Purine metabolism_Homo sapiens_hsa002300.10355727
130AMPK signaling pathway_Homo sapiens_hsa041520.09781772
131Circadian rhythm_Homo sapiens_hsa047100.08671194
132Base excision repair_Homo sapiens_hsa034100.07118878
133N-Glycan biosynthesis_Homo sapiens_hsa005100.05620381
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04752188
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.01173880
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.00871889
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0790155
138Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0768035
139Type II diabetes mellitus_Homo sapiens_hsa04930-0.0583785
140Prion diseases_Homo sapiens_hsa05020-0.0291280
141Mismatch repair_Homo sapiens_hsa03430-0.0108707
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0078643

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