SIRT7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.20948374
2DNA deamination (GO:0045006)6.68205580
3proline metabolic process (GO:0006560)5.84511371
4positive regulation of protein homooligomerization (GO:0032464)5.23434618
5transcription from mitochondrial promoter (GO:0006390)5.21023401
6replication fork processing (GO:0031297)4.99419025
7embryonic process involved in female pregnancy (GO:0060136)4.87646466
8cellular response to zinc ion (GO:0071294)4.65554883
9oxidative demethylation (GO:0070989)4.64070146
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.61230332
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.61230332
12modulation by symbiont of host immune response (GO:0052553)4.61230332
13positive regulation by symbiont of host defense response (GO:0052509)4.61230332
14modulation by symbiont of host defense response (GO:0052031)4.61230332
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.61230332
16response to peptidoglycan (GO:0032494)4.53858109
17negative regulation of cell killing (GO:0031342)4.51146375
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.51146375
19positive regulation of gamma-delta T cell activation (GO:0046645)4.33693592
20maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.30427737
21immunoglobulin mediated immune response (GO:0016064)4.23846507
22macrophage activation involved in immune response (GO:0002281)4.22729402
23regulation of protein homooligomerization (GO:0032462)4.19281184
24detection of bacterium (GO:0016045)4.16577072
25regulation of integrin activation (GO:0033623)4.16224210
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.14964772
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.14964772
28detection of other organism (GO:0098543)4.14880170
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.10973346
30neutrophil activation involved in immune response (GO:0002283)4.04460266
31poly(A)+ mRNA export from nucleus (GO:0016973)3.95020117
32NIK/NF-kappaB signaling (GO:0038061)3.93126991
33regulation of interferon-beta biosynthetic process (GO:0045357)3.92329691
34negative regulation of erythrocyte differentiation (GO:0045647)3.83697234
35antigen processing and presentation of endogenous antigen (GO:0019883)3.73687020
36regulation of gamma-delta T cell differentiation (GO:0045586)3.64944541
37mitochondrial DNA metabolic process (GO:0032042)3.64191043
38mitotic G1 DNA damage checkpoint (GO:0031571)3.58613896
39response to type I interferon (GO:0034340)3.56777906
40type I interferon signaling pathway (GO:0060337)3.55245152
41cellular response to type I interferon (GO:0071357)3.55245152
42telomere maintenance via semi-conservative replication (GO:0032201)3.54948572
43mRNA cleavage (GO:0006379)3.54330127
44negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.53248463
45regulation of B cell receptor signaling pathway (GO:0050855)3.44650019
46detection of external biotic stimulus (GO:0098581)3.44091002
47regulation of mast cell degranulation (GO:0043304)3.41197239
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.38324670
49cellular extravasation (GO:0045123)3.35517958
50negative regulation of lymphocyte mediated immunity (GO:0002707)3.31877713
51mitotic G1/S transition checkpoint (GO:0044819)3.31601759
52phospholipid scrambling (GO:0017121)3.29695551
53regulation of isotype switching to IgG isotypes (GO:0048302)3.29599945
54positive regulation of lamellipodium assembly (GO:0010592)3.28690023
55viral mRNA export from host cell nucleus (GO:0046784)3.28529089
56positive regulation of developmental pigmentation (GO:0048087)3.28239827
57response to muramyl dipeptide (GO:0032495)3.28078552
58respiratory burst (GO:0045730)3.26760625
59negative regulation of JAK-STAT cascade (GO:0046426)3.24373743
60regulation of gamma-delta T cell activation (GO:0046643)3.22457890
61pentose metabolic process (GO:0019321)3.21709812
62germinal center formation (GO:0002467)3.20370504
63interferon-gamma-mediated signaling pathway (GO:0060333)3.19987471
64B cell mediated immunity (GO:0019724)3.19864313
65T cell migration (GO:0072678)3.17255471
66neutrophil activation (GO:0042119)3.16544996
67positive regulation of interferon-alpha production (GO:0032727)3.16495467
68negative regulation of protein oligomerization (GO:0032460)3.15757050
69response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.15289219
70response to host immune response (GO:0052572)3.15289219
71negative regulation of interleukin-12 production (GO:0032695)3.14097477
72G1 DNA damage checkpoint (GO:0044783)3.12927527
73positive thymic T cell selection (GO:0045059)3.12553088
74glutamine family amino acid biosynthetic process (GO:0009084)3.12073701
75positive regulation by host of viral transcription (GO:0043923)3.11229021
76regulation of interferon-alpha production (GO:0032647)3.09508194
77negative regulation of T cell mediated immunity (GO:0002710)3.08637888
78regulation of myeloid leukocyte mediated immunity (GO:0002886)3.08503798
79granulocyte activation (GO:0036230)3.08393627
80regulation of mast cell activation involved in immune response (GO:0033006)3.07890266
81negative regulation of leukocyte mediated immunity (GO:0002704)3.07348863
82myeloid cell activation involved in immune response (GO:0002275)3.07309116
83regulation of B cell differentiation (GO:0045577)3.06965340
84lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06572619
85positive regulation of protein oligomerization (GO:0032461)3.05693661
86interferon-gamma secretion (GO:0072643)3.05011406
87negative regulation of interleukin-6 production (GO:0032715)3.04365055
88regulation of leukocyte degranulation (GO:0043300)3.03896985
89GDP-mannose metabolic process (GO:0019673)3.03847890
90regulation of antigen processing and presentation (GO:0002577)3.03794160
91cellular response to ATP (GO:0071318)3.02697176
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.01743725
93DNA integration (GO:0015074)3.00673586
94somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00227858
95somatic hypermutation of immunoglobulin genes (GO:0016446)3.00227858
96detection of biotic stimulus (GO:0009595)2.99516160
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.96111706
98response to host (GO:0075136)2.96111706
99response to host defenses (GO:0052200)2.96111706
100regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95486926
101tolerance induction (GO:0002507)2.95382428
102detection of molecule of bacterial origin (GO:0032490)2.94225018
103regulation of T cell tolerance induction (GO:0002664)2.92397551
104negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.92084318
105B cell receptor signaling pathway (GO:0050853)2.90399860
106macrophage activation (GO:0042116)2.90255034
107regulation of T-helper 2 cell differentiation (GO:0045628)2.90168419
108thymic T cell selection (GO:0045061)2.90143562
109negative regulation of tumor necrosis factor production (GO:0032720)2.89992204
110production of molecular mediator involved in inflammatory response (GO:0002532)2.89153495
111regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89079993
112base-excision repair (GO:0006284)2.88989891
113response to interleukin-15 (GO:0070672)2.85841913
114T cell selection (GO:0045058)2.84836695
115positive regulation of antigen processing and presentation (GO:0002579)2.83691108
116nucleotide-excision repair, DNA gap filling (GO:0006297)2.83537487
117negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.83484770
118regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82945058
119negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.82358997
120regulation of protein oligomerization (GO:0032459)2.81132749
121regulation of T cell mediated cytotoxicity (GO:0001914)2.79538893
122activation of MAPKKK activity (GO:0000185)2.79321020
123positive regulation of T cell mediated cytotoxicity (GO:0001916)2.78789943
124very-low-density lipoprotein particle assembly (GO:0034379)2.78402983
125myeloid dendritic cell differentiation (GO:0043011)2.77205137
126antigen processing and presentation via MHC class Ib (GO:0002475)2.77056505
127sulfur amino acid catabolic process (GO:0000098)2.76832109
128negative regulation of stress fiber assembly (GO:0051497)2.76258716
129sphingomyelin metabolic process (GO:0006684)2.75968671
130telomere maintenance via recombination (GO:0000722)2.75566108
131regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.75304156
132regulation of natural killer cell mediated immunity (GO:0002715)2.75304156
133termination of RNA polymerase II transcription (GO:0006369)2.73966004
134embryonic placenta development (GO:0001892)2.73658590
135base-excision repair, AP site formation (GO:0006285)2.73185028
136DNA strand elongation involved in DNA replication (GO:0006271)2.72804790
137defense response to protozoan (GO:0042832)2.72713622
138negative T cell selection (GO:0043383)2.72583188
139leukocyte aggregation (GO:0070486)2.72487212
140negative regulation of cell cycle arrest (GO:0071157)2.72457261
141microglial cell activation (GO:0001774)2.72436083
142heme biosynthetic process (GO:0006783)2.72395965
143regulation of tolerance induction (GO:0002643)2.72369662
144regulation of regulatory T cell differentiation (GO:0045589)2.72056481
145regulation of mast cell activation (GO:0033003)2.71722769
146cellular response to interleukin-15 (GO:0071350)2.71292490
147regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70713071
148negative regulation of fatty acid biosynthetic process (GO:0045717)2.68757448
149regulation of lamellipodium assembly (GO:0010591)2.68754967
150negative regulation of innate immune response (GO:0045824)2.68468620
151positive regulation of B cell differentiation (GO:0045579)2.68442841
152positive regulation of Cdc42 GTPase activity (GO:0043089)2.68270996
153membrane invagination (GO:0010324)2.67804045
154mannose metabolic process (GO:0006013)2.67366110
155negative thymic T cell selection (GO:0045060)2.67336833
156mitochondrial RNA metabolic process (GO:0000959)2.66844443
157positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66228782
158leukocyte degranulation (GO:0043299)2.65079079
159regulation of mitochondrial depolarization (GO:0051900)2.64659537
160establishment of protein localization to mitochondrial membrane (GO:0090151)2.60582515
161positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.58994469
162DNA strand elongation (GO:0022616)2.58088286
163negative regulation of mRNA processing (GO:0050686)2.57611000
164DNA strand renaturation (GO:0000733)2.56065287
165positive regulation of lamellipodium organization (GO:1902745)2.52665080
166regulation of translational fidelity (GO:0006450)2.51075207
167leukocyte cell-cell adhesion (GO:0007159)2.50567754
168formation of translation preinitiation complex (GO:0001731)2.50144240
169regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.49471578
170negative regulation of RNA splicing (GO:0033119)2.48205221
171response to protozoan (GO:0001562)2.47248393
172establishment of apical/basal cell polarity (GO:0035089)2.46313194
173negative regulation of viral release from host cell (GO:1902187)2.44007114
174negative regulation of nitric oxide biosynthetic process (GO:0045019)2.43544590
175regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.43173295
176nuclear envelope reassembly (GO:0031468)2.42801038
177mitotic nuclear envelope reassembly (GO:0007084)2.42801038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* VDR_21846776_ChIP-Seq_THP-1_Human3.29674952
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.82308243
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45833191
4MYC_22102868_ChIP-Seq_BL_Human2.45555370
5SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41821814
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39747942
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38962821
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.35680711
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.20681454
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20247917
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12576797
12PU.1_20513432_ChIP-Seq_Bcells_Mouse2.01700518
13IRF8_21731497_ChIP-ChIP_J774_Mouse1.99281435
14MAF_26560356_Chip-Seq_TH1_Human1.92280451
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91850803
16* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89953381
17LXR_22292898_ChIP-Seq_THP-1_Human1.87425038
18MYC_18555785_ChIP-Seq_MESCs_Mouse1.87199232
19* VDR_24763502_ChIP-Seq_THP-1_Human1.85784510
20E2F7_22180533_ChIP-Seq_HELA_Human1.85705984
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83228431
22SPI1_23127762_ChIP-Seq_K562_Human1.82236566
23GATA1_22383799_ChIP-Seq_G1ME_Mouse1.77987590
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77878280
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77332458
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.73808553
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73164607
28* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71479917
29SPI1_23547873_ChIP-Seq_NB4_Human1.70145465
30UTX_26944678_Chip-Seq_JUKART_Human1.69818755
31* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.68988432
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68895398
33* RUNX1_22412390_ChIP-Seq_EML_Mouse1.66153537
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64919005
35MYB_26560356_Chip-Seq_TH1_Human1.64465285
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63898731
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60784368
38* MAF_26560356_Chip-Seq_TH2_Human1.59300200
39RUNX_20019798_ChIP-Seq_JUKART_Human1.57777691
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56681927
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.55663772
42P68_20966046_ChIP-Seq_HELA_Human1.54280449
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.52309100
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.51845229
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51413914
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50690124
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.50238985
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48562979
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48173914
50* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.47964318
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47913246
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.47710236
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47366191
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46761919
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45882071
56MYB_26560356_Chip-Seq_TH2_Human1.45663408
57IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43488876
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.42252595
59SCL_19346495_ChIP-Seq_HPC-7_Human1.41580545
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.40234394
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39202607
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38271768
63* TCF7_22412390_ChIP-Seq_EML_Mouse1.37776542
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.36624536
65* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34812657
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33254871
67KDM2B_26808549_Chip-Seq_DND41_Human1.31778360
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31750987
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.29627426
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.28299952
71NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28018689
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.27773883
73PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27091412
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.27011266
75BCOR_27268052_Chip-Seq_Bcells_Human1.26875825
76* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25761206
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.24075113
78* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23360038
79MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22814751
80* GABP_19822575_ChIP-Seq_HepG2_Human1.22164881
81VDR_23849224_ChIP-Seq_CD4+_Human1.22044920
82NCOR1_26117541_ChIP-Seq_K562_Human1.21926403
83BCL6_27268052_Chip-Seq_Bcells_Human1.21838228
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21649842
85E2F1_20622854_ChIP-Seq_HELA_Human1.21314259
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21308454
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.20707331
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20352416
89GATA1_19941826_ChIP-Seq_K562_Human1.19954490
90IRF8_27001747_Chip-Seq_BMDM_Mouse1.19652084
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19547852
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19380470
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19359819
94STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18608727
95CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18410068
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.17897454
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17834024
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17003284
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16212555
100* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15938553
101SMC4_20622854_ChIP-Seq_HELA_Human1.15600262
102STAT1_20625510_ChIP-Seq_HELA_Human1.15598322
103KDM2B_26808549_Chip-Seq_JURKAT_Human1.14709497
104CIITA_25753668_ChIP-Seq_RAJI_Human1.13965926
105YY1_21170310_ChIP-Seq_MESCs_Mouse1.13906491
106RACK7_27058665_Chip-Seq_MCF-7_Human1.13511968
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13471223
108LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13262321
109* CTCF_26484167_Chip-Seq_Bcells_Mouse1.13133981
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13089481
111SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13050414
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12766483
113* ETS1_21867929_ChIP-Seq_TH2_Mouse1.11907594
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11070153
115CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09987775
116E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09848937
117PHF8_20622854_ChIP-Seq_HELA_Human1.09506872
118GATA3_27048872_Chip-Seq_THYMUS_Human1.08759553
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08241953
120HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07890786
121GATA1_19941827_ChIP-Seq_MEL_Mouse1.07655578
122* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.06993286
123CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06966872
124TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06739724
125* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06391503
126* DCP1A_22483619_ChIP-Seq_HELA_Human1.06233213
127* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05816247
128KDM5A_27292631_Chip-Seq_BREAST_Human1.05339233
129P300_27268052_Chip-Seq_Bcells_Human1.05084090
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04873236
131RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04726583
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00336992
133SA1_27219007_Chip-Seq_Bcells_Human0.99531606
134SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97656396
135PU_27001747_Chip-Seq_BMDM_Mouse0.95995597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.51063948
2MP0000685_abnormal_immune_system3.38632543
3MP0009278_abnormal_bone_marrow3.07493272
4MP0006082_CNS_inflammation2.85865917
5MP0001835_abnormal_antigen_presentation2.76743473
6MP0003763_abnormal_thymus_physiology2.52696385
7MP0005671_abnormal_response_to2.51982007
8MP0001545_abnormal_hematopoietic_system2.38245446
9MP0005397_hematopoietic_system_phenotyp2.38245446
10MP0005174_abnormal_tail_pigmentation2.33141309
11MP0001873_stomach_inflammation2.32252881
12MP0001800_abnormal_humoral_immune2.25947552
13MP0005075_abnormal_melanosome_morpholog2.23923470
14MP0002009_preneoplasia2.23246489
15MP0002166_altered_tumor_susceptibility2.21205460
16MP0005058_abnormal_lysosome_morphology2.19016698
17MP0005451_abnormal_body_composition2.17267926
18MP0009785_altered_susceptibility_to2.13790173
19MP0002405_respiratory_system_inflammati2.13543436
20MP0005387_immune_system_phenotype2.12649602
21MP0001790_abnormal_immune_system2.12649602
22MP0009840_abnormal_foam_cell2.07055602
23MP0005025_abnormal_response_to2.05057324
24MP0003172_abnormal_lysosome_physiology2.04786960
25MP0009333_abnormal_splenocyte_physiolog2.04054084
26MP0002398_abnormal_bone_marrow2.02450956
27MP0002396_abnormal_hematopoietic_system2.01959750
28MP0000689_abnormal_spleen_morphology2.00065837
29MP0005464_abnormal_platelet_physiology1.99033014
30MP0003656_abnormal_erythrocyte_physiolo1.92169790
31* MP0002723_abnormal_immune_serum1.91622330
32MP0005365_abnormal_bile_salt1.90482364
33MP0002420_abnormal_adaptive_immunity1.88232368
34MP0002452_abnormal_antigen_presenting1.87301700
35MP0001819_abnormal_immune_cell1.86447724
36MP0005000_abnormal_immune_tolerance1.85763927
37MP0008260_abnormal_autophagy1.84507591
38MP0010155_abnormal_intestine_physiology1.81833058
39MP0005171_absent_coat_pigmentation1.76370619
40MP0001533_abnormal_skeleton_physiology1.74513443
41* MP0000716_abnormal_immune_system1.74403206
42MP0005085_abnormal_gallbladder_physiolo1.73296011
43MP0003436_decreased_susceptibility_to1.72294884
44MP0003866_abnormal_defecation1.72244900
45MP0002722_abnormal_immune_system1.71700059
46MP0000490_abnormal_crypts_of1.69453750
47MP0002419_abnormal_innate_immunity1.65125238
48MP0002006_tumorigenesis1.58144013
49MP0004381_abnormal_hair_follicle1.57545430
50MP0000858_altered_metastatic_potential1.56351036
51MP0003724_increased_susceptibility_to1.53427652
52* MP0002429_abnormal_blood_cell1.52082374
53MP0001853_heart_inflammation1.51768401
54MP0000015_abnormal_ear_pigmentation1.45252268
55MP0003183_abnormal_peptide_metabolism1.41958608
56MP0002148_abnormal_hypersensitivity_rea1.41682878
57MP0000703_abnormal_thymus_morphology1.39456554
58MP0001845_abnormal_inflammatory_respons1.33135147
59MP0003303_peritoneal_inflammation1.29363441
60MP0005360_urolithiasis1.26566779
61MP0008995_early_reproductive_senescence1.25975774
62MP0010094_abnormal_chromosome_stability1.25884852
63MP0000465_gastrointestinal_hemorrhage1.24400378
64MP0003453_abnormal_keratinocyte_physiol1.22737571
65MP0002019_abnormal_tumor_incidence1.20759939
66MP0004947_skin_inflammation1.18975206
67MP0000371_diluted_coat_color1.18908169
68MP0005310_abnormal_salivary_gland1.17659608
69MP0002139_abnormal_hepatobiliary_system1.16055276
70MP0002132_abnormal_respiratory_system1.15387287
71MP0004510_myositis1.11848251
72MP0003191_abnormal_cellular_cholesterol1.09683329
73MP0008058_abnormal_DNA_repair1.08216573
74MP0002998_abnormal_bone_remodeling1.07456530
75* MP0008469_abnormal_protein_level1.07162683
76MP0005076_abnormal_cell_differentiation1.06455739
77MP0000609_abnormal_liver_physiology1.05591424
78MP0004957_abnormal_blastocyst_morpholog1.01706166
79MP0002277_abnormal_respiratory_mucosa0.98069869
80MP0002933_joint_inflammation0.94358388
81MP0005166_decreased_susceptibility_to0.92236069
82MP0003693_abnormal_embryo_hatching0.91280606
83MP0003806_abnormal_nucleotide_metabolis0.90396051
84MP0004185_abnormal_adipocyte_glucose0.89907293
85MP0001851_eye_inflammation0.89262355
86MP0004808_abnormal_hematopoietic_stem0.84100250
87MP0000470_abnormal_stomach_morphology0.79265177
88MP0000604_amyloidosis0.79232546
89MP0003448_altered_tumor_morphology0.79020977
90MP0000343_altered_response_to0.78308798
91MP0001764_abnormal_homeostasis0.76745116
92MP0002138_abnormal_hepatobiliary_system0.76669046
93MP0003045_fibrosis0.75840990
94MP0008875_abnormal_xenobiotic_pharmacok0.75573537
95MP0001348_abnormal_lacrimal_gland0.74782542
96MP0000639_abnormal_adrenal_gland0.74209393
97MP0000477_abnormal_intestine_morphology0.74162465
98MP0000598_abnormal_liver_morphology0.73650989
99MP0009763_increased_sensitivity_to0.72436436
100MP0005083_abnormal_biliary_tract0.71938981
101MP0001986_abnormal_taste_sensitivity0.70860657
102MP0003075_altered_response_to0.69881659
103MP0005319_abnormal_enzyme/_coenzyme0.69678422
104MP0005390_skeleton_phenotype0.69275909
105MP0001666_abnormal_nutrient_absorption0.69159872
106MP0003077_abnormal_cell_cycle0.68614857
107MP0002075_abnormal_coat/hair_pigmentati0.67734082
108MP0005584_abnormal_enzyme/coenzyme_acti0.67433478
109MP0006072_abnormal_retinal_apoptosis0.67076263
110MP0003300_gastrointestinal_ulcer0.66846937
111MP0004883_abnormal_blood_vessel0.66155485
112MP0004142_abnormal_muscle_tone0.65274506
113MP0009764_decreased_sensitivity_to0.65205126
114MP0004264_abnormal_extraembryonic_tissu0.65056202
115MP0003705_abnormal_hypodermis_morpholog0.64894692
116MP0001663_abnormal_digestive_system0.64770072
117* MP0000313_abnormal_cell_death0.64418395
118MP0003111_abnormal_nucleus_morphology0.64247940
119MP0004019_abnormal_vitamin_homeostasis0.63946572
120MP0008874_decreased_physiological_sensi0.63708222
121MP0003828_pulmonary_edema0.63644886
122MP0002332_abnormal_exercise_endurance0.63606024
123MP0009931_abnormal_skin_appearance0.62831750
124MP0005266_abnormal_metabolism0.61871370
125* MP0005164_abnormal_response_to0.61281826
126MP0009765_abnormal_xenobiotic_induced0.60974517
127MP0005666_abnormal_adipose_tissue0.60964967
128MP0005375_adipose_tissue_phenotype0.60392034
129MP0002136_abnormal_kidney_physiology0.59141655

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.78797598
2Abnormality of macrophages (HP:0004311)4.77100086
3Increased IgM level (HP:0003496)4.72980389
4Myositis (HP:0100614)4.57396610
5Poikiloderma (HP:0001029)4.26162459
6Orchitis (HP:0100796)4.23933350
7Albinism (HP:0001022)3.92071134
8Optic neuritis (HP:0100653)3.89878219
9Retrobulbar optic neuritis (HP:0100654)3.89878219
10Gastrointestinal infarctions (HP:0005244)3.62642768
11Recurrent gram-negative bacterial infections (HP:0005420)3.61299134
12Nasal polyposis (HP:0100582)3.57892840
13Colitis (HP:0002583)3.45819329
14Recurrent fungal infections (HP:0002841)3.36604289
15Dysostosis multiplex (HP:0000943)3.36071912
16IgG deficiency (HP:0004315)3.29132713
17IgM deficiency (HP:0002850)3.28782170
18Abnormality of T cell physiology (HP:0011840)3.27993697
19Abnormality of T cells (HP:0002843)3.26733368
20Inflammation of the large intestine (HP:0002037)3.26005840
21Vasculitis (HP:0002633)3.24903738
22Hypochromic microcytic anemia (HP:0004840)3.24485893
23IgA deficiency (HP:0002720)3.19628359
24Encephalitis (HP:0002383)3.17448567
25T lymphocytopenia (HP:0005403)3.17411370
26Urinary glycosaminoglycan excretion (HP:0003541)3.16571992
27Mucopolysacchariduria (HP:0008155)3.16571992
28Gastrointestinal inflammation (HP:0004386)3.15569877
29Abnormality of the nasal mucosa (HP:0000433)3.10061321
30Fatigue (HP:0012378)3.07212613
31Annular pancreas (HP:0001734)3.05850276
32Abnormality of glycolipid metabolism (HP:0010969)3.03718476
33Abnormality of liposaccharide metabolism (HP:0010968)3.03718476
34Abnormality of glycosphingolipid metabolism (HP:0004343)3.03718476
35Abnormality of polysaccharide metabolism (HP:0011012)2.99813361
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.99813361
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.99813361
38Abnormality of T cell number (HP:0011839)2.96182089
39Cellulitis (HP:0100658)2.94316587
40Gingivitis (HP:0000230)2.93762499
41Elevated erythrocyte sedimentation rate (HP:0003565)2.93147958
42Increased cerebral lipofuscin (HP:0011813)2.91920220
43Abnormal hemoglobin (HP:0011902)2.90230773
44Hypochromic anemia (HP:0001931)2.88807197
45Rib fusion (HP:0000902)2.85668156
46Intestinal fistula (HP:0100819)2.84689094
47Prolonged bleeding time (HP:0003010)2.83053878
48Pulmonary infiltrates (HP:0002113)2.82817728
49Increased serum ferritin (HP:0003281)2.82585534
50Recurrent abscess formation (HP:0002722)2.82474411
51Facial hemangioma (HP:0000329)2.79286584
52Recurrent viral infections (HP:0004429)2.78905775
53Abnormality of male internal genitalia (HP:0000022)2.77742873
54Concave nail (HP:0001598)2.77499647
55Chronic otitis media (HP:0000389)2.76529083
56Spontaneous hematomas (HP:0007420)2.74752103
57Hemoptysis (HP:0002105)2.73997748
58Ulnar bowing (HP:0003031)2.73669229
59Panhypogammaglobulinemia (HP:0003139)2.73552794
60Recurrent bronchitis (HP:0002837)2.72800911
61Urticaria (HP:0001025)2.71230346
62Rectal fistula (HP:0100590)2.70421426
63Rectovaginal fistula (HP:0000143)2.70421426
64Keratoconjunctivitis sicca (HP:0001097)2.69247339
65Vaginal fistula (HP:0004320)2.68901583
66Severe combined immunodeficiency (HP:0004430)2.68708058
67Polycythemia (HP:0001901)2.66279837
68Basal cell carcinoma (HP:0002671)2.65428723
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.64078320
70Loss of speech (HP:0002371)2.62609855
71Eczematoid dermatitis (HP:0000976)2.58069981
72Gastrointestinal stroma tumor (HP:0100723)2.55787828
73Hypergammaglobulinemia (HP:0010702)2.55289427
74Abnormality of iron homeostasis (HP:0011031)2.54972168
75Abnormality of B cell number (HP:0010975)2.54130036
76B lymphocytopenia (HP:0010976)2.54130036
77Hypokinesia (HP:0002375)2.51388404
78Combined immunodeficiency (HP:0005387)2.50990507
79Alopecia of scalp (HP:0002293)2.49332749
80Cheilitis (HP:0100825)2.49332421
81Squamous cell carcinoma (HP:0002860)2.49014841
82Tongue fasciculations (HP:0001308)2.47338486
83Keratoconjunctivitis (HP:0001096)2.47139285
84Meningitis (HP:0001287)2.45572647
85Granulocytopenia (HP:0001913)2.41888823
86Leukocytosis (HP:0001974)2.39334453
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.38336936
88Premature skin wrinkling (HP:0100678)2.36408314
89Vacuolated lymphocytes (HP:0001922)2.35895573
90Chest pain (HP:0100749)2.35327253
91Anorexia (HP:0002039)2.34189441
92Recurrent bacterial skin infections (HP:0005406)2.30967614
93Lymphopenia (HP:0001888)2.30806195
94Epistaxis (HP:0000421)2.30206122
95Abnormality of aromatic amino acid family metabolism (HP:0004338)2.26944225
96Abnormal number of erythroid precursors (HP:0012131)2.25404858
97Malnutrition (HP:0004395)2.25244458
98Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22652655
99Thyroiditis (HP:0100646)2.22228597
100Stomatitis (HP:0010280)2.22150648
101Slow saccadic eye movements (HP:0000514)2.21553753
102Lymphoma (HP:0002665)2.21040595
103Osteomyelitis (HP:0002754)2.20104372
104Microcytic anemia (HP:0001935)2.18540234
105Chronic obstructive pulmonary disease (HP:0006510)2.17805952
106Obstructive lung disease (HP:0006536)2.17805952
107Hypertensive crisis (HP:0100735)2.17559936
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16829634
109Agammaglobulinemia (HP:0004432)2.16651352
110Exertional dyspnea (HP:0002875)2.16364887
111Abnormality of transition element cation homeostasis (HP:0011030)2.15993976
112Acute lymphatic leukemia (HP:0006721)2.14086623
113Abnormality of cells of the erythroid lineage (HP:0012130)2.13343905
114Abnormal platelet volume (HP:0011876)2.13229146
115Petechiae (HP:0000967)2.11359534
116Hypobetalipoproteinemia (HP:0003563)2.11254978
117Recurrent skin infections (HP:0001581)2.11003278
118Premature graying of hair (HP:0002216)2.09600029
119Verrucae (HP:0200043)2.09219639
120Papilloma (HP:0012740)2.09219639
121Muscle fiber atrophy (HP:0100295)2.08895981
122Joint stiffness (HP:0001387)2.07634089
123Muscle fibrillation (HP:0010546)2.05584684
124Abnormal platelet function (HP:0011869)2.05395843
125Impaired platelet aggregation (HP:0003540)2.05395843
126Autoimmune thrombocytopenia (HP:0001973)2.04502613
127Keratitis (HP:0000491)2.03413135
128Hemorrhage of the eye (HP:0011885)2.02974586
129Arterial thrombosis (HP:0004420)2.02901944
130Lower limb hyperreflexia (HP:0002395)2.02585796
131Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00808997
132Large for gestational age (HP:0001520)2.00091708
133Emphysema (HP:0002097)2.00001618
134Chronic mucocutaneous candidiasis (HP:0002728)1.99734277
135Recurrent cutaneous fungal infections (HP:0011370)1.99734277
136Type 2 muscle fiber atrophy (HP:0003554)1.98950362
137Myocardial infarction (HP:0001658)1.98070653
138Bowed forearm bones (HP:0003956)1.98016451
139Bowing of the arm (HP:0006488)1.98016451
140Increased IgE level (HP:0003212)1.97331081
141Recurrent sinusitis (HP:0011108)1.97191167
142Anteriorly placed anus (HP:0001545)1.96848203
143Progressive neurologic deterioration (HP:0002344)1.96407403
144Purpura (HP:0000979)1.94899558
145Restrictive lung disease (HP:0002091)1.94640217
146Thrombocytosis (HP:0001894)1.94633796
147Mediastinal lymphadenopathy (HP:0100721)1.94362198
148Sepsis (HP:0100806)1.93290348
149Abnormality of cells of the lymphoid lineage (HP:0012140)1.92999206
150Eosinophilia (HP:0001880)1.92800250
151Amyloidosis (HP:0011034)1.92482196
152Systemic lupus erythematosus (HP:0002725)1.92095826
153Recurrent pneumonia (HP:0006532)1.90896867
154Hypertriglyceridemia (HP:0002155)1.88943645

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.36454108
2ICK4.00618478
3MAP3K63.99574722
4MAP4K13.57016460
5MAP3K113.12926020
6CSK2.87214534
7PIM22.66305752
8PINK12.57366113
9DDR22.54238854
10MATK2.45207214
11FGR2.27133219
12PRKD22.18331149
13MAP3K32.04822123
14DAPK11.98997805
15BLK1.96118136
16MARK31.94695042
17YES11.75511480
18SMG11.72582294
19PIM11.70010476
20DYRK1B1.65171809
21TYRO31.64863925
22TBK11.57377317
23TXK1.51440525
24UHMK11.46576470
25ZAP701.46034025
26SIK31.45595861
27NME21.41557230
28KIT1.38525226
29MAP3K101.35437457
30GRK61.33377379
31IKBKE1.32827504
32BTK1.28768535
33IRAK41.28631460
34LCK1.23580366
35IRAK21.22433562
36MAP3K11.22416870
37LYN1.22163014
38TYK21.21361859
39CDK71.19219375
40ERN11.17585926
41BMX1.17215338
42MAPK111.13307104
43IKBKB1.13161274
44TRPM71.09680643
45MAP2K21.09067176
46JAK31.08828719
47TESK21.07974358
48CDK61.07572423
49SYK1.02541007
50STK100.98705641
51CDK120.97286630
52KDR0.95899849
53PDPK10.95612046
54DYRK30.95510681
55PTK60.93361832
56RPS6KA60.93347692
57MARK20.92546505
58TNK20.91137312
59MST1R0.90800872
60PDK10.89676315
61ITK0.88892700
62RPS6KC10.88326456
63RPS6KL10.88326456
64CSF1R0.87621922
65IRAK10.86838952
66TAOK30.84285586
67EPHB10.81467947
68TEC0.80191954
69MAP2K60.76192568
70MAPK40.75892213
71RIPK40.73800346
72HIPK20.73425295
73FGFR40.72198231
74GSK3A0.71968478
75RAF10.71715412
76FLT30.70775193
77STK160.66766118
78EPHA20.66074401
79STK110.65012157
80FES0.64427663
81MAP2K30.63876861
82KSR20.63827855
83CDK190.63372316
84MAP3K80.62802368
85MAP3K120.62073770
86SIK20.61108879
87MAP3K140.61107620
88HCK0.60913415
89NLK0.60800713
90BCKDK0.57500360
91JAK10.56069637
92JAK20.55445709
93PTK2B0.51526030
94PRKCQ0.50722182
95LRRK20.49541330
96MELK0.49415685
97RPS6KA20.49004236
98CDK40.48967141
99PDGFRA0.48750994
100IRAK30.48454756
101PAK40.47517796
102PKN20.47092580
103CHUK0.46450924
104CHEK20.45884886
105EIF2AK10.44993752
106MAP3K70.44789715
107ABL10.43960707
108MAPK30.43174259
109EGFR0.43112461
110EEF2K0.42957432
111CDC42BPA0.42824332
112PRKAA20.42556331
113MAPK120.41708907
114TRIB30.41293122
115TLK10.40025130
116MAP3K20.39923778
117RPS6KA10.39659661
118CSNK1G10.39466733
119MAP3K130.39416065
120TAOK20.39302289
121MAP3K50.38969692
122RIPK10.37801372
123PRKG20.37600611
124SIK10.36089703
125TGFBR20.35976617
126PRKCD0.35681566
127CLK10.34013833
128MAPKAPK20.33327580
129TNIK0.33282630
130CDK90.29594886
131CSNK2A10.29396210
132TAOK10.29274846
133PRPF4B0.27418553

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.45633625
2Base excision repair_Homo sapiens_hsa034103.57884786
3DNA replication_Homo sapiens_hsa030303.48121152
4Mismatch repair_Homo sapiens_hsa034303.39955577
5Fatty acid biosynthesis_Homo sapiens_hsa000613.17506680
6Sulfur relay system_Homo sapiens_hsa041222.19475302
7Ribosome_Homo sapiens_hsa030102.13573206
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.09742168
9NOD-like receptor signaling pathway_Homo sapiens_hsa046211.97094893
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.89373572
11Folate biosynthesis_Homo sapiens_hsa007901.86105460
12B cell receptor signaling pathway_Homo sapiens_hsa046621.85747560
13Type I diabetes mellitus_Homo sapiens_hsa049401.84585980
14Toxoplasmosis_Homo sapiens_hsa051451.77708023
15TNF signaling pathway_Homo sapiens_hsa046681.69206226
16Influenza A_Homo sapiens_hsa051641.64244813
17Measles_Homo sapiens_hsa051621.63982160
18Nucleotide excision repair_Homo sapiens_hsa034201.59314582
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.55493136
20Homologous recombination_Homo sapiens_hsa034401.52253020
21Shigellosis_Homo sapiens_hsa051311.51813359
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51309870
23Spliceosome_Homo sapiens_hsa030401.46887295
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43869305
25Staphylococcus aureus infection_Homo sapiens_hsa051501.41852923
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.39460585
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39284534
28Hematopoietic cell lineage_Homo sapiens_hsa046401.38906725
29Allograft rejection_Homo sapiens_hsa053301.38512658
30Hepatitis C_Homo sapiens_hsa051601.32821768
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.31137115
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29965137
33Caffeine metabolism_Homo sapiens_hsa002321.27144801
34Arginine and proline metabolism_Homo sapiens_hsa003301.25480768
35Notch signaling pathway_Homo sapiens_hsa043301.23246197
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22020046
37Herpes simplex infection_Homo sapiens_hsa051681.21586633
38Leishmaniasis_Homo sapiens_hsa051401.20104670
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18848605
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18358588
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17282163
42Antigen processing and presentation_Homo sapiens_hsa046121.16297556
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15290402
44T cell receptor signaling pathway_Homo sapiens_hsa046601.14778998
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14424422
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13046687
47Asthma_Homo sapiens_hsa053101.12791985
48Rheumatoid arthritis_Homo sapiens_hsa053231.11548480
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11541223
50African trypanosomiasis_Homo sapiens_hsa051431.11021332
51ABC transporters_Homo sapiens_hsa020101.09600476
52p53 signaling pathway_Homo sapiens_hsa041151.06115459
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.06051096
54Acute myeloid leukemia_Homo sapiens_hsa052211.04115369
55Pertussis_Homo sapiens_hsa051331.02384999
56Phagosome_Homo sapiens_hsa041451.01151314
57Fatty acid metabolism_Homo sapiens_hsa012121.01078530
58Non-small cell lung cancer_Homo sapiens_hsa052230.98980715
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.97067895
60Legionellosis_Homo sapiens_hsa051340.93331367
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.91814467
62Fanconi anemia pathway_Homo sapiens_hsa034600.89783551
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.89325166
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.88811856
65Other glycan degradation_Homo sapiens_hsa005110.88612418
66Fatty acid elongation_Homo sapiens_hsa000620.87163736
67Biosynthesis of amino acids_Homo sapiens_hsa012300.87080367
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86102456
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85547629
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83650684
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.82253889
72Lysine degradation_Homo sapiens_hsa003100.82066385
73Osteoclast differentiation_Homo sapiens_hsa043800.81979106
74VEGF signaling pathway_Homo sapiens_hsa043700.80755205
75Lysosome_Homo sapiens_hsa041420.80224852
76Pentose phosphate pathway_Homo sapiens_hsa000300.79556797
77Steroid biosynthesis_Homo sapiens_hsa001000.79509390
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.79394034
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76971107
80Circadian rhythm_Homo sapiens_hsa047100.75887059
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75462446
82Endocytosis_Homo sapiens_hsa041440.70860762
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70416371
84Prolactin signaling pathway_Homo sapiens_hsa049170.69303716
85Hepatitis B_Homo sapiens_hsa051610.68408139
86Selenocompound metabolism_Homo sapiens_hsa004500.67795582
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.66265304
88RNA polymerase_Homo sapiens_hsa030200.66128314
89HTLV-I infection_Homo sapiens_hsa051660.66016562
90Pyrimidine metabolism_Homo sapiens_hsa002400.63206326
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63122145
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.62757606
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62448017
94mTOR signaling pathway_Homo sapiens_hsa041500.62429170
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.61198495
96Epstein-Barr virus infection_Homo sapiens_hsa051690.60508013
97Autoimmune thyroid disease_Homo sapiens_hsa053200.60157720
98Non-homologous end-joining_Homo sapiens_hsa034500.59988205
99Arginine biosynthesis_Homo sapiens_hsa002200.59986497
100Chemokine signaling pathway_Homo sapiens_hsa040620.59832415
101Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59015469
102Viral myocarditis_Homo sapiens_hsa054160.58625377
103mRNA surveillance pathway_Homo sapiens_hsa030150.58611854
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58067446
105Insulin resistance_Homo sapiens_hsa049310.57195702
106Platelet activation_Homo sapiens_hsa046110.56721912
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.56180832
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55514280
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55415896
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52443954
111FoxO signaling pathway_Homo sapiens_hsa040680.52055091
112Apoptosis_Homo sapiens_hsa042100.51613310
113RNA transport_Homo sapiens_hsa030130.51032164
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50315770
115Histidine metabolism_Homo sapiens_hsa003400.49460396
116Renal cell carcinoma_Homo sapiens_hsa052110.49123748
117Malaria_Homo sapiens_hsa051440.47551826
118Complement and coagulation cascades_Homo sapiens_hsa046100.45599931
119Peroxisome_Homo sapiens_hsa041460.45190249
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44547710
121MAPK signaling pathway_Homo sapiens_hsa040100.43877921
122Chronic myeloid leukemia_Homo sapiens_hsa052200.43058721
123N-Glycan biosynthesis_Homo sapiens_hsa005100.42658170
124Proteasome_Homo sapiens_hsa030500.41689086
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.40201887
126Choline metabolism in cancer_Homo sapiens_hsa052310.38767330
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38373200
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38027173
129Viral carcinogenesis_Homo sapiens_hsa052030.36822625
130Cell cycle_Homo sapiens_hsa041100.36639104
131Fructose and mannose metabolism_Homo sapiens_hsa000510.36360473
132Dorso-ventral axis formation_Homo sapiens_hsa043200.35278027
133Inositol phosphate metabolism_Homo sapiens_hsa005620.34868399
134Bladder cancer_Homo sapiens_hsa052190.34524210
135Tuberculosis_Homo sapiens_hsa051520.34092084
136Pancreatic cancer_Homo sapiens_hsa052120.33420993
137Systemic lupus erythematosus_Homo sapiens_hsa053220.32568111
138Endometrial cancer_Homo sapiens_hsa052130.31700868
139Prostate cancer_Homo sapiens_hsa052150.31401860
140Graft-versus-host disease_Homo sapiens_hsa053320.30193464
141ErbB signaling pathway_Homo sapiens_hsa040120.28699601
142Tryptophan metabolism_Homo sapiens_hsa003800.28573863
143GnRH signaling pathway_Homo sapiens_hsa049120.28515428
144HIF-1 signaling pathway_Homo sapiens_hsa040660.27838028
145Salmonella infection_Homo sapiens_hsa051320.27733245
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.27016804
147Regulation of autophagy_Homo sapiens_hsa041400.25891492
148Galactose metabolism_Homo sapiens_hsa000520.24669884

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