SIT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)8.47164407
2negative T cell selection (GO:0043383)8.42651350
3negative thymic T cell selection (GO:0045060)8.00552775
4positive thymic T cell selection (GO:0045059)7.99047064
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.81255656
6positive T cell selection (GO:0043368)7.57273344
7cytidine deamination (GO:0009972)7.42088713
8cytidine metabolic process (GO:0046087)7.42088713
9cytidine catabolic process (GO:0006216)7.42088713
10thymic T cell selection (GO:0045061)7.33379729
11regulation of gamma-delta T cell differentiation (GO:0045586)7.17377902
12T cell selection (GO:0045058)6.88374690
13pyrimidine ribonucleoside catabolic process (GO:0046133)6.88075564
14regulation of gamma-delta T cell activation (GO:0046643)6.59438588
15cellular response to interleukin-15 (GO:0071350)6.49684511
16T cell receptor signaling pathway (GO:0050852)6.34268607
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.18232409
18positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.12179646
19interferon-gamma production (GO:0032609)6.12088297
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.12049576
21negative regulation of cell killing (GO:0031342)6.12049576
22response to interleukin-15 (GO:0070672)6.10324573
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.00933316
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.00933316
25regulation of isotype switching to IgG isotypes (GO:0048302)5.95077002
26regulation of T cell tolerance induction (GO:0002664)5.92730694
27T cell costimulation (GO:0031295)5.86022860
28lymphocyte costimulation (GO:0031294)5.78140815
29DNA deamination (GO:0045006)5.75409783
30leukocyte aggregation (GO:0070486)5.59420984
31antigen receptor-mediated signaling pathway (GO:0050851)5.47866924
32regulation of T cell receptor signaling pathway (GO:0050856)5.40703707
33antigen processing and presentation of endogenous antigen (GO:0019883)5.28544897
34regulation of B cell receptor signaling pathway (GO:0050855)5.03926153
35T cell migration (GO:0072678)5.02794704
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.97253922
37positive regulation of tolerance induction (GO:0002645)4.81007922
38tolerance induction (GO:0002507)4.75540286
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.68019962
40sequestering of actin monomers (GO:0042989)4.51687337
41mast cell activation (GO:0045576)4.45317993
42positive regulation of alpha-beta T cell proliferation (GO:0046641)4.43919860
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.40052707
44regulation of interleukin-2 biosynthetic process (GO:0045076)4.37067791
45regulation of alpha-beta T cell proliferation (GO:0046640)4.35382884
46positive regulation of B cell differentiation (GO:0045579)4.35053791
47regulation of tolerance induction (GO:0002643)4.22183090
48regulation of activation of Janus kinase activity (GO:0010533)4.13909719
49positive regulation of interleukin-2 production (GO:0032743)4.09830828
50negative regulation of viral genome replication (GO:0045071)4.03145423
51negative regulation of T cell receptor signaling pathway (GO:0050860)3.95380569
52T cell differentiation (GO:0030217)3.94081886
53positive regulation of T cell mediated cytotoxicity (GO:0001916)3.89796315
54regulation of response to interferon-gamma (GO:0060330)3.86945153
55negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.82700085
56immunoglobulin mediated immune response (GO:0016064)3.81767467
57regulation of T cell mediated cytotoxicity (GO:0001914)3.80586679
58regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.80018498
59negative regulation of T cell apoptotic process (GO:0070233)3.79649961
60V(D)J recombination (GO:0033151)3.79623228
61positive regulation of natural killer cell mediated immunity (GO:0002717)3.77977867
62positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.77977867
63B cell receptor signaling pathway (GO:0050853)3.77569890
64immune response-activating cell surface receptor signaling pathway (GO:0002429)3.76916014
65positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.76717532
66negative regulation of T cell mediated immunity (GO:0002710)3.76001868
67regulation of type I interferon-mediated signaling pathway (GO:0060338)3.71912900
68T cell activation (GO:0042110)3.66187945
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.66067318
70regulation of natural killer cell mediated immunity (GO:0002715)3.66067318
71lymphocyte chemotaxis (GO:0048247)3.63881552
72lymphocyte migration (GO:0072676)3.61976891
73regulation of immunoglobulin mediated immune response (GO:0002889)3.61478714
74positive regulation of isotype switching (GO:0045830)3.61231294
75dendritic cell chemotaxis (GO:0002407)3.60540315
76activated T cell proliferation (GO:0050798)3.58954033
77regulation of defense response to virus by virus (GO:0050690)3.57786959
78negative regulation of lymphocyte mediated immunity (GO:0002707)3.57727426
79regulation of isotype switching (GO:0045191)3.54947491
80positive regulation of cell killing (GO:0031343)3.52750521
81positive regulation of granulocyte differentiation (GO:0030854)3.52512860
82response to type I interferon (GO:0034340)3.52373502
83regulation of B cell mediated immunity (GO:0002712)3.51563064
84positive regulation of immunoglobulin mediated immune response (GO:0002891)3.51078669
85positive regulation of B cell mediated immunity (GO:0002714)3.51078669
86mast cell activation involved in immune response (GO:0002279)3.50261363
87mast cell degranulation (GO:0043303)3.50261363
88natural killer cell activation (GO:0030101)3.48403236
89cellular response to type I interferon (GO:0071357)3.47766097
90type I interferon signaling pathway (GO:0060337)3.47766097
91regulation of regulatory T cell differentiation (GO:0045589)3.47208231
92respiratory burst (GO:0045730)3.44318066
93antigen processing and presentation via MHC class Ib (GO:0002475)3.40407517
94positive regulation of calcium-mediated signaling (GO:0050850)3.38194410
95regulation of cell killing (GO:0031341)3.37866048
96T cell homeostasis (GO:0043029)3.36985206
97regulation of B cell differentiation (GO:0045577)3.36432103
98regulation of leukocyte mediated cytotoxicity (GO:0001910)3.34613177
99positive regulation of humoral immune response (GO:0002922)3.33688773
100NIK/NF-kappaB signaling (GO:0038061)3.32680967
101pyrimidine nucleoside catabolic process (GO:0046135)3.31917998
102chemokine-mediated signaling pathway (GO:0070098)3.31916535
103Arp2/3 complex-mediated actin nucleation (GO:0034314)3.30592780
104positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.30528145
105alpha-beta T cell differentiation (GO:0046632)3.29152865
106negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.28840450
107regulation of immunoglobulin production (GO:0002637)3.28183048
108negative regulation of leukocyte mediated immunity (GO:0002704)3.27786098
109mucosal-associated lymphoid tissue development (GO:0048537)3.27080798
110Peyers patch development (GO:0048541)3.27080798
111regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.26114874
112regulation of lymphocyte chemotaxis (GO:1901623)3.25438772
113B cell mediated immunity (GO:0019724)3.25040198
114positive regulation of DNA recombination (GO:0045911)3.24282016
115positive regulation of immunoglobulin production (GO:0002639)3.23119336
116actin nucleation (GO:0045010)3.23075123
117positive regulation of T cell activation (GO:0050870)3.22755164
118leukocyte cell-cell adhesion (GO:0007159)3.22193527
119alpha-beta T cell activation (GO:0046631)3.20121866
120positive regulation of interleukin-8 secretion (GO:2000484)3.19731499
121regulation of T cell chemotaxis (GO:0010819)3.17595657
122positive regulation of T cell chemotaxis (GO:0010820)3.17595657
123regulation of interleukin-2 production (GO:0032663)3.16080154
124granulocyte activation (GO:0036230)3.15292600
125detection of bacterium (GO:0016045)3.14221263
126cellular response to interleukin-4 (GO:0071353)3.13340061
127neutrophil activation (GO:0042119)3.12944871
128positive regulation of lymphocyte migration (GO:2000403)3.11870906
129cellular defense response (GO:0006968)3.11485917
130natural killer cell differentiation (GO:0001779)3.11094416
131positive regulation of lamellipodium assembly (GO:0010592)3.10217066
132heterotypic cell-cell adhesion (GO:0034113)3.09212755
133negative regulation of phagocytosis (GO:0050765)3.09125997
134regulation of interleukin-4 production (GO:0032673)3.07542260
135lymphocyte homeostasis (GO:0002260)3.03532880
136dendritic cell migration (GO:0036336)3.03297915
137positive regulation of defense response to virus by host (GO:0002230)3.01056201
138positive regulation of interleukin-4 production (GO:0032753)3.00772407
139positive regulation of T cell mediated immunity (GO:0002711)2.99933699

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.69013034
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.14831652
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.75505041
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.26174725
5MYC_22102868_ChIP-Seq_BL_Human3.68453303
6RUNX_20019798_ChIP-Seq_JUKART_Human3.64703548
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.58983224
8* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.57737437
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.55201111
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.55180558
11MYB_26560356_Chip-Seq_TH2_Human3.41594099
12E2F7_22180533_ChIP-Seq_HELA_Human3.19270875
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.03969078
14MAF_26560356_Chip-Seq_TH1_Human3.02122262
15* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.97277108
16* UTX_26944678_Chip-Seq_JUKART_Human2.92083613
17* MYB_26560356_Chip-Seq_TH1_Human2.81538006
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.70276086
19* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46846411
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.32944882
21MAF_26560356_Chip-Seq_TH2_Human2.27544427
22VDR_21846776_ChIP-Seq_THP-1_Human2.24656033
23GATA3_27048872_Chip-Seq_THYMUS_Human2.14764459
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.12493461
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97675090
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95885395
27* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94413310
28* RUNX1_22412390_ChIP-Seq_EML_Mouse1.90910849
29SPI1_23547873_ChIP-Seq_NB4_Human1.88094213
30* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83429940
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.77767530
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73811325
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73147596
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70356835
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68666100
36SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68617638
37TCF7_22412390_ChIP-Seq_EML_Mouse1.62498458
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.58934553
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.58372609
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57884584
41VDR_24763502_ChIP-Seq_THP-1_Human1.54502262
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.49043116
43SCL_19346495_ChIP-Seq_HPC-7_Human1.47058869
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.46749765
45KDM2B_26808549_Chip-Seq_DND41_Human1.45123645
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43308054
47VDR_23849224_ChIP-Seq_CD4+_Human1.43133034
48MYB_21317192_ChIP-Seq_ERMYB_Mouse1.42296452
49CIITA_25753668_ChIP-Seq_RAJI_Human1.38114688
50FOXP3_21729870_ChIP-Seq_TREG_Human1.36993581
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.32247774
52* BCL6_27268052_Chip-Seq_Bcells_Human1.32099071
53SPI1_23127762_ChIP-Seq_K562_Human1.31440403
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31197558
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28407855
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28210262
57GATA3_26560356_Chip-Seq_TH2_Human1.27859882
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27413631
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20621404
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16556594
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.16338185
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12472934
63PU_27001747_Chip-Seq_BMDM_Mouse1.08572150
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08543548
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07605759
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07331749
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07243331
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06589461
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06073831
70* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06028740
71* BCOR_27268052_Chip-Seq_Bcells_Human1.04761683
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04189460
73* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03030767
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.00560677
75* ELK3_25401928_ChIP-Seq_HUVEC_Human0.98846059
76BP1_19119308_ChIP-ChIP_Hs578T_Human0.98266824
77GABP_17652178_ChIP-ChIP_JURKAT_Human0.96676343
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96197076
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95541183
80LXR_22292898_ChIP-Seq_THP-1_Human0.94484461
81* ELF1_20517297_ChIP-Seq_JURKAT_Human0.93028991
82ELK1_19687146_ChIP-ChIP_HELA_Human0.91847462
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91026293
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90207961
85TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90204602
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89267193
87* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88753723
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88744047
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88077982
90* P300_27268052_Chip-Seq_Bcells_Human0.87652158
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87630307
92XRN2_22483619_ChIP-Seq_HELA_Human0.87507405
93* KDM2B_26808549_Chip-Seq_JURKAT_Human0.86953100
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86495840
95* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86489519
96HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86152781
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85485900
98* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82880434
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.82361958
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.82052976
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81973824
102IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81562496
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.80600267
104EST1_17652178_ChIP-ChIP_JURKAT_Human0.80238435
105SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.80113846
106SA1_27219007_Chip-Seq_Bcells_Human0.79725688
107SPI1_20517297_ChIP-Seq_HL60_Human0.79390643
108* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79370711
109GATA3_26560356_Chip-Seq_TH1_Human0.78124118
110CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77325505
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75865822
112SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75136489
113FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.72192851
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71316424
115* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.70878356
116FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.70670022
117* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68816634
118CTCF_26484167_Chip-Seq_Bcells_Mouse0.66333303
119CTCF_27219007_Chip-Seq_ERYTHROID_Human0.65470761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.28701810
2MP0005671_abnormal_response_to5.03129622
3MP0000685_abnormal_immune_system3.95561687
4MP0002166_altered_tumor_susceptibility3.66229960
5MP0001835_abnormal_antigen_presentation3.63426362
6MP0001800_abnormal_humoral_immune3.36319572
7MP0009333_abnormal_splenocyte_physiolog3.09105721
8MP0001790_abnormal_immune_system3.05562301
9MP0005387_immune_system_phenotype3.05562301
10MP0009785_altered_susceptibility_to3.05210056
11MP0002006_tumorigenesis2.97350789
12* MP0002398_abnormal_bone_marrow2.97187655
13* MP0002420_abnormal_adaptive_immunity2.93726825
14* MP0001819_abnormal_immune_cell2.91549973
15* MP0005000_abnormal_immune_tolerance2.91394900
16* MP0000703_abnormal_thymus_morphology2.87005864
17* MP0002723_abnormal_immune_serum2.86528396
18MP0002452_abnormal_antigen_presenting2.66224947
19MP0006082_CNS_inflammation2.59507586
20* MP0000716_abnormal_immune_system2.58223870
21MP0005025_abnormal_response_to2.56692737
22MP0004947_skin_inflammation2.51294821
23MP0002405_respiratory_system_inflammati2.49855718
24* MP0002722_abnormal_immune_system2.49404452
25MP0000689_abnormal_spleen_morphology2.36522771
26MP0003724_increased_susceptibility_to2.35837695
27MP0002933_joint_inflammation2.25301450
28MP0010155_abnormal_intestine_physiology2.25119771
29* MP0002429_abnormal_blood_cell2.06991479
30MP0002396_abnormal_hematopoietic_system1.98171971
31MP0003866_abnormal_defecation1.91929581
32MP0001873_stomach_inflammation1.90475428
33MP0004381_abnormal_hair_follicle1.87006295
34MP0003436_decreased_susceptibility_to1.85614229
35MP0002148_abnormal_hypersensitivity_rea1.81225936
36MP0004510_myositis1.74377441
37MP0001845_abnormal_inflammatory_respons1.70900442
38MP0003300_gastrointestinal_ulcer1.68841968
39MP0002419_abnormal_innate_immunity1.67479332
40MP0005310_abnormal_salivary_gland1.63345331
41MP0005464_abnormal_platelet_physiology1.62492423
42MP0001853_heart_inflammation1.43590405
43MP0000858_altered_metastatic_potential1.43074578
44MP0002132_abnormal_respiratory_system1.34258479
45MP0002009_preneoplasia1.33371369
46MP0001851_eye_inflammation1.25746778
47MP0002277_abnormal_respiratory_mucosa1.15636634
48MP0004808_abnormal_hematopoietic_stem1.15160191
49MP0002019_abnormal_tumor_incidence1.14677129
50MP0005075_abnormal_melanosome_morpholog1.08283965
51MP0008469_abnormal_protein_level1.07984886
52MP0002163_abnormal_gland_morphology1.06067197
53MP0000490_abnormal_crypts_of1.03816188
54MP0003448_altered_tumor_morphology1.01811167
55MP0003303_peritoneal_inflammation0.98297262
56MP0001533_abnormal_skeleton_physiology0.90659703
57MP0000465_gastrointestinal_hemorrhage0.88859726
58MP0005166_decreased_susceptibility_to0.86295516
59MP0002998_abnormal_bone_remodeling0.85228574
60MP0001348_abnormal_lacrimal_gland0.79268730
61MP0008057_abnormal_DNA_replication0.79223566
62MP0001919_abnormal_reproductive_system0.76715107
63MP0003646_muscle_fatigue0.73527247
64MP0010094_abnormal_chromosome_stability0.72391015
65MP0001545_abnormal_hematopoietic_system0.71752283
66MP0005397_hematopoietic_system_phenotyp0.71752283
67MP0010234_abnormal_vibrissa_follicle0.71676169
68MP0009763_increased_sensitivity_to0.71328583
69MP0002138_abnormal_hepatobiliary_system0.68771146
70MP0003077_abnormal_cell_cycle0.68285356
71MP0005023_abnormal_wound_healing0.67916703
72MP0001663_abnormal_digestive_system0.66998993
73MP0001243_abnormal_dermal_layer0.62298108
74MP0002822_catalepsy0.61537211
75MP0000477_abnormal_intestine_morphology0.60628950
76MP0003183_abnormal_peptide_metabolism0.60211603
77MP0002095_abnormal_skin_pigmentation0.59889332
78MP0003045_fibrosis0.59095376
79MP0003786_premature_aging0.57778081
80MP0009765_abnormal_xenobiotic_induced0.57145282
81MP0008260_abnormal_autophagy0.56980892
82MP0009764_decreased_sensitivity_to0.56111064
83MP0001191_abnormal_skin_condition0.53702099
84MP0002136_abnormal_kidney_physiology0.53361720
85MP0004883_abnormal_blood_vessel0.52974012
86MP0004957_abnormal_blastocyst_morpholog0.52799556
87MP0002693_abnormal_pancreas_physiology0.52728284
88MP0008873_increased_physiological_sensi0.51628744
89MP0001986_abnormal_taste_sensitivity0.51468595
90MP0000609_abnormal_liver_physiology0.51239118
91MP0003795_abnormal_bone_structure0.50017915
92MP0001216_abnormal_epidermal_layer0.49183411
93MP0010352_gastrointestinal_tract_polyps0.48270663
94MP0005645_abnormal_hypothalamus_physiol0.46840174
95MP0000604_amyloidosis0.45730851
96MP0003693_abnormal_embryo_hatching0.45340916
97MP0009643_abnormal_urine_homeostasis0.45194754
98MP0005390_skeleton_phenotype0.44354100
99MP0005451_abnormal_body_composition0.44264746
100MP0008058_abnormal_DNA_repair0.43696805
101MP0000313_abnormal_cell_death0.43471382
102MP0005174_abnormal_tail_pigmentation0.42055731
103MP0005076_abnormal_cell_differentiation0.41568807
104MP0003453_abnormal_keratinocyte_physiol0.41380747
105MP0000367_abnormal_coat/_hair0.41133897
106MP0005379_endocrine/exocrine_gland_phen0.40060521
107MP0002168_other_aberrant_phenotype0.39609274
108MP0002083_premature_death0.38893843
109MP0009278_abnormal_bone_marrow0.38790918
110MP0008961_abnormal_basal_metabolism0.38340987
111MP0003191_abnormal_cellular_cholesterol0.38234336
112MP0008874_decreased_physiological_sensi0.37931847
113MP0009642_abnormal_blood_homeostasis0.36664573
114MP0008569_lethality_at_weaning0.36131264
115MP0003111_abnormal_nucleus_morphology0.35905915
116MP0003279_aneurysm0.35499912
117MP0000249_abnormal_blood_vessel0.35475029
118MP0008007_abnormal_cellular_replicative0.35137332
119MP0003075_altered_response_to0.34821543
120MP0003787_abnormal_imprinting0.34333189
121MP0001765_abnormal_ion_homeostasis0.34163496
122MP0000372_irregular_coat_pigmentation0.33473154
123MP0005584_abnormal_enzyme/coenzyme_acti0.33302366
124MP0003806_abnormal_nucleotide_metabolis0.33229372
125MP0009931_abnormal_skin_appearance0.32999827
126MP0002877_abnormal_melanocyte_morpholog0.32261326
127MP0000920_abnormal_myelination0.32030357
128MP0000343_altered_response_to0.31618439

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.28716699
2Abnormality of T cell number (HP:0011839)8.14394454
3Severe combined immunodeficiency (HP:0004430)7.21968362
4Combined immunodeficiency (HP:0005387)6.74045577
5Elevated erythrocyte sedimentation rate (HP:0003565)5.82571371
6Recurrent bronchitis (HP:0002837)5.72555775
7Abnormality of T cells (HP:0002843)5.71941473
8Autoimmune hemolytic anemia (HP:0001890)5.70687123
9IgG deficiency (HP:0004315)5.55131821
10Thyroiditis (HP:0100646)5.47320037
11Stomatitis (HP:0010280)5.27184217
12B lymphocytopenia (HP:0010976)5.25522922
13Abnormality of B cell number (HP:0010975)5.25522922
14Abnormality of macrophages (HP:0004311)4.79880424
15Hypoplasia of the thymus (HP:0000778)4.79337653
16IgM deficiency (HP:0002850)4.78943392
17Abnormality of eosinophils (HP:0001879)4.67789484
18Panhypogammaglobulinemia (HP:0003139)4.61013692
19Recurrent fungal infections (HP:0002841)4.51252111
20Chronic mucocutaneous candidiasis (HP:0002728)4.49813566
21Recurrent cutaneous fungal infections (HP:0011370)4.49813566
22Increased IgM level (HP:0003496)4.47119721
23Recurrent viral infections (HP:0004429)4.31527868
24Eosinophilia (HP:0001880)4.27721819
25Lymphopenia (HP:0001888)4.19354292
26Abnormality of cells of the lymphoid lineage (HP:0012140)4.14122937
27Aplastic anemia (HP:0001915)3.88047787
28Agammaglobulinemia (HP:0004432)3.82870220
29Leukocytosis (HP:0001974)3.79912904
30Chronic otitis media (HP:0000389)3.78081598
31Chronic diarrhea (HP:0002028)3.76459053
32Myositis (HP:0100614)3.67164989
33Granulocytopenia (HP:0001913)3.63535380
34Nasal polyposis (HP:0100582)3.60716404
35Eczematoid dermatitis (HP:0000976)3.49333249
36Abnormality of T cell physiology (HP:0011840)3.48440760
37Recurrent sinusitis (HP:0011108)3.45033903
38Pustule (HP:0200039)3.43493304
39Abnormal delayed hypersensitivity skin test (HP:0002963)3.25154653
40Meningitis (HP:0001287)3.23456400
41Bronchitis (HP:0012387)3.18027576
42Joint swelling (HP:0001386)3.12554733
43Abnormality of the fingertips (HP:0001211)3.06836878
44Abnormality of the nasal mucosa (HP:0000433)3.04409596
45Recurrent otitis media (HP:0000403)3.01136221
46Recurrent gram-negative bacterial infections (HP:0005420)3.00751515
47Autoimmune thrombocytopenia (HP:0001973)2.94325194
48Lymphoma (HP:0002665)2.91531923
49Hypergammaglobulinemia (HP:0010702)2.84488369
50Colitis (HP:0002583)2.78270345
51IgA deficiency (HP:0002720)2.77353336
52Chest pain (HP:0100749)2.74994070
53Verrucae (HP:0200043)2.74598497
54Papilloma (HP:0012740)2.74598497
55Vasculitis (HP:0002633)2.74157300
56Acute hepatic failure (HP:0006554)2.70460794
57Recurrent skin infections (HP:0001581)2.64325062
58Urticaria (HP:0001025)2.63848800
59Recurrent abscess formation (HP:0002722)2.62682369
60Basal cell carcinoma (HP:0002671)2.57163956
61Hypoproteinemia (HP:0003075)2.54477679
62Hemoptysis (HP:0002105)2.49335526
63Mediastinal lymphadenopathy (HP:0100721)2.48653883
64Chronic obstructive pulmonary disease (HP:0006510)2.44918105
65Obstructive lung disease (HP:0006536)2.44918105
66Chronic sinusitis (HP:0011109)2.43809154
67Retrobulbar optic neuritis (HP:0100654)2.39661231
68Optic neuritis (HP:0100653)2.39661231
69Hypochromic anemia (HP:0001931)2.39597908
70Gangrene (HP:0100758)2.37077801
71Pulmonary infiltrates (HP:0002113)2.34426404
72Gastrointestinal infarctions (HP:0005244)2.34001598
73Encephalitis (HP:0002383)2.33015108
74Abnormality of the pleura (HP:0002103)2.28317985
75Aplasia/Hypoplasia of the thymus (HP:0010515)2.28048724
76Hemiplegia (HP:0002301)2.23911962
77Orchitis (HP:0100796)2.21272684
78Gastrointestinal inflammation (HP:0004386)2.21023561
79Inflammation of the large intestine (HP:0002037)2.19349158
80Gastrointestinal stroma tumor (HP:0100723)2.09970417
81Thrombocytosis (HP:0001894)2.07837205
82Reduced subcutaneous adipose tissue (HP:0003758)2.03617591
83Spontaneous hematomas (HP:0007420)2.02106228
84Cheilitis (HP:0100825)2.00983904
85Hypochromic microcytic anemia (HP:0004840)2.00427686
86Restrictive lung disease (HP:0002091)1.99695222
87Sepsis (HP:0100806)1.99521286
88Skin rash (HP:0000988)1.98783945
89Abnormality of the prostate (HP:0008775)1.97700319
90Poikiloderma (HP:0001029)1.96490133
91Bronchiectasis (HP:0002110)1.94134387
92Increased IgE level (HP:0003212)1.92944753
93Keratoconjunctivitis sicca (HP:0001097)1.91669955
94Premature loss of primary teeth (HP:0006323)1.88614028
95Keratoconjunctivitis (HP:0001096)1.86263840
96Cellulitis (HP:0100658)1.85886314
97Anorexia (HP:0002039)1.84578413
98Skin ulcer (HP:0200042)1.82306170
99Episodic fever (HP:0001954)1.81777633
100Emphysema (HP:0002097)1.79161067
101Osteomyelitis (HP:0002754)1.79103786
102Recurrent bacterial skin infections (HP:0005406)1.75319586
103Amyotrophic lateral sclerosis (HP:0007354)1.75246515
104Abnormality of the thymus (HP:0000777)1.73313011
105Entropion (HP:0000621)1.72238360
106Ureteral stenosis (HP:0000071)1.71423728
107Arterial thrombosis (HP:0004420)1.70418504
108Hepatitis (HP:0012115)1.67954128
109Epistaxis (HP:0000421)1.67893629
110Pulmonary embolism (HP:0002204)1.67535669
111Gingivitis (HP:0000230)1.67335191
112Cellular immunodeficiency (HP:0005374)1.65651277
113Petechiae (HP:0000967)1.64769186
114Amaurosis fugax (HP:0100576)1.63248324
115Muscle fiber atrophy (HP:0100295)1.62340176
116Arthralgia (HP:0002829)1.60159073
117Microcytic anemia (HP:0001935)1.58888516

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.34326478
2MAP4K15.83951732
3ZAP703.60453701
4ITK3.29090047
5RIPK43.28999915
6FGFR43.25566430
7IKBKE2.95541762
8KDR2.77480225
9JAK32.66992961
10GRK62.45633306
11TYK22.45493568
12STK102.24973574
13LCK2.15376081
14TESK22.14170675
15MAP3K102.07568624
16MAP3K112.02396803
17JAK12.00975551
18NLK1.93596453
19SYK1.93310657
20TBK11.92516297
21FGFR31.89836868
22TEC1.79079131
23MST41.77473798
24BLK1.75090600
25MAP3K141.68854279
26BTK1.68497841
27CSK1.51744279
28HCK1.50822358
29PRPF4B1.40608832
30NME21.38678400
31BCKDK1.31818973
32EEF2K1.24413694
33TAOK31.23325176
34PRKCH1.23009459
35LRRK21.20505420
36PRKCQ1.15381169
37KIT1.08599033
38MAP3K121.08138483
39MAP3K131.06023884
40TLK11.00777246
41LYN0.97885340
42TNK20.95111809
43IKBKB0.92684396
44CAMKK10.87923731
45CAMKK20.87870783
46CLK10.86362664
47PIK3CG0.86200548
48SCYL20.81005423
49IRAK40.74420797
50PKN20.72827001
51MARK30.70062204
52BRD40.68081506
53EPHB10.67784542
54FYN0.67105482
55CSF1R0.66087704
56ERN10.65866873
57VRK10.65788271
58SIK20.65763725
59JAK20.65676181
60PIM10.64337313
61FES0.62638424
62TESK10.62462764
63FGR0.61881814
64INSR0.61670413
65CHUK0.61431912
66MAPK110.61411541
67GRK70.59586016
68MAP3K70.58776888
69FGFR10.57719062
70CDK40.52610693
71LIMK10.52401216
72SIK30.51684488
73PDGFRB0.51582477
74SMG10.50206348
75MAPKAPK30.49821792
76TGFBR20.47841887
77STK40.47651933
78MAP2K30.46292469
79FGFR20.45879529
80MAP3K10.43985288
81RPS6KA40.43750606
82IGF1R0.42197779
83MARK20.41054377
84BMPR20.40277381
85MAPK70.40259569
86TAOK20.40153902
87PASK0.39861304
88PDK10.39119453
89EIF2AK10.39088603
90HIPK20.38963176
91ADRBK20.36716452
92MAPK120.36423547
93DYRK1B0.35070917
94MAP2K60.34811826
95RPS6KB20.34778133
96NEK20.34422338
97EIF2AK30.33065277
98CDK120.31831560
99VRK20.31754125
100PRKD20.30910045
101TYRO30.30828122
102DAPK10.30288013
103MAPK40.30200852
104MAPK30.28434295
105AURKA0.27501624
106ILK0.27396894
107STK160.27005166
108MAP3K30.26608115
109PRKCD0.25580848
110CSNK1G30.24270749
111CDK90.24017616
112TGFBR10.23986277
113CSNK1A1L0.23176971
114TAOK10.22160144
115CSNK1G10.22055248
116RPS6KA50.20950265
117ABL10.19452693
118MELK0.18898039
119SRC0.18882331
120MAP3K50.18673402
121ALK0.17521146
122EPHA30.17476423
123MYLK0.17302314
124ZAK0.17240484
125CDC70.16619726
126PRKCB0.16583758
127CDC42BPA0.16281007
128PDPK10.16007006
129MAPKAPK20.15420079
130MAP3K80.14475279
131SIK10.13514791
132RPS6KA60.13037611

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.72834909
2T cell receptor signaling pathway_Homo sapiens_hsa046604.24545910
3Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.39247060
4Graft-versus-host disease_Homo sapiens_hsa053323.11736247
5Measles_Homo sapiens_hsa051623.09266090
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.93003623
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.74012772
8Antigen processing and presentation_Homo sapiens_hsa046122.71346490
9Hematopoietic cell lineage_Homo sapiens_hsa046402.64478596
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.58084185
11Allograft rejection_Homo sapiens_hsa053302.37448444
12Autoimmune thyroid disease_Homo sapiens_hsa053201.96905296
13Viral myocarditis_Homo sapiens_hsa054161.85450288
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77659654
15Ribosome_Homo sapiens_hsa030101.74864498
16B cell receptor signaling pathway_Homo sapiens_hsa046621.69461198
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69056381
18Leishmaniasis_Homo sapiens_hsa051401.67411729
19Osteoclast differentiation_Homo sapiens_hsa043801.67132570
20Herpes simplex infection_Homo sapiens_hsa051681.49523100
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.48988126
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38660142
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34160909
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.31647532
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.27467602
26Non-homologous end-joining_Homo sapiens_hsa034501.24951731
27Shigellosis_Homo sapiens_hsa051311.20528581
28HTLV-I infection_Homo sapiens_hsa051661.15808012
29Chemokine signaling pathway_Homo sapiens_hsa040621.15247718
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.06863797
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06206750
32Hepatitis B_Homo sapiens_hsa051611.05159427
33Toxoplasmosis_Homo sapiens_hsa051450.98175902
34Spliceosome_Homo sapiens_hsa030400.96324168
35Apoptosis_Homo sapiens_hsa042100.94853098
36Influenza A_Homo sapiens_hsa051640.92330106
37Type I diabetes mellitus_Homo sapiens_hsa049400.89773682
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86671486
39NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85128233
40DNA replication_Homo sapiens_hsa030300.82481289
41Proteasome_Homo sapiens_hsa030500.81526856
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81322661
43Acute myeloid leukemia_Homo sapiens_hsa052210.80812021
44Mismatch repair_Homo sapiens_hsa034300.80476735
45Viral carcinogenesis_Homo sapiens_hsa052030.77574458
46Alcoholism_Homo sapiens_hsa050340.77316930
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76312229
48Epstein-Barr virus infection_Homo sapiens_hsa051690.75702935
49Colorectal cancer_Homo sapiens_hsa052100.74949036
50Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73725423
51Asthma_Homo sapiens_hsa053100.73282420
52p53 signaling pathway_Homo sapiens_hsa041150.72754919
53Pancreatic cancer_Homo sapiens_hsa052120.70877029
54Base excision repair_Homo sapiens_hsa034100.68737782
55Platelet activation_Homo sapiens_hsa046110.67187498
56TNF signaling pathway_Homo sapiens_hsa046680.66451251
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65105368
58Hepatitis C_Homo sapiens_hsa051600.64964851
59African trypanosomiasis_Homo sapiens_hsa051430.62904360
60VEGF signaling pathway_Homo sapiens_hsa043700.60566394
61Phagosome_Homo sapiens_hsa041450.59130326
62Nucleotide excision repair_Homo sapiens_hsa034200.58665621
63Salmonella infection_Homo sapiens_hsa051320.57076980
64Tuberculosis_Homo sapiens_hsa051520.56444067
65Legionellosis_Homo sapiens_hsa051340.56084116
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50595170
67Malaria_Homo sapiens_hsa051440.49181077
68Prolactin signaling pathway_Homo sapiens_hsa049170.47120876
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46098710
70Staphylococcus aureus infection_Homo sapiens_hsa051500.45538798
71Chronic myeloid leukemia_Homo sapiens_hsa052200.44505803
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44210735
73Non-small cell lung cancer_Homo sapiens_hsa052230.40780997
74RNA degradation_Homo sapiens_hsa030180.40524217
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40485188
76Notch signaling pathway_Homo sapiens_hsa043300.39605508
77Endocytosis_Homo sapiens_hsa041440.39564249
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39308714
79Pentose phosphate pathway_Homo sapiens_hsa000300.35634761
80Caffeine metabolism_Homo sapiens_hsa002320.35322765
81Adherens junction_Homo sapiens_hsa045200.31728596
82Rap1 signaling pathway_Homo sapiens_hsa040150.31576947
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29046035
84Thyroid cancer_Homo sapiens_hsa052160.28946387
85RNA polymerase_Homo sapiens_hsa030200.27865613
86FoxO signaling pathway_Homo sapiens_hsa040680.27773890
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27644053
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27346080
89Homologous recombination_Homo sapiens_hsa034400.27284748
90Systemic lupus erythematosus_Homo sapiens_hsa053220.27108422
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26980491
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.26151750
93Inositol phosphate metabolism_Homo sapiens_hsa005620.25186023
94mRNA surveillance pathway_Homo sapiens_hsa030150.24768195
95Prion diseases_Homo sapiens_hsa050200.21616333
96Pertussis_Homo sapiens_hsa051330.20587395
97Rheumatoid arthritis_Homo sapiens_hsa053230.20296919
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.19925745
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.19421048
100Other glycan degradation_Homo sapiens_hsa005110.18881773
101Small cell lung cancer_Homo sapiens_hsa052220.18121189
102Pyrimidine metabolism_Homo sapiens_hsa002400.17486085
103Cell cycle_Homo sapiens_hsa041100.16701489
104Basal transcription factors_Homo sapiens_hsa030220.16579267
105MAPK signaling pathway_Homo sapiens_hsa040100.12784563
106Pathways in cancer_Homo sapiens_hsa052000.12129518
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11321992
108RNA transport_Homo sapiens_hsa030130.11237012
109Endometrial cancer_Homo sapiens_hsa052130.10790518
110Parkinsons disease_Homo sapiens_hsa050120.10637279
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10330288
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.10080684
113Oxidative phosphorylation_Homo sapiens_hsa001900.09164857
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08616524
115Sulfur relay system_Homo sapiens_hsa041220.07908876
116Ras signaling pathway_Homo sapiens_hsa040140.02986543
117Insulin resistance_Homo sapiens_hsa049310.02919358
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.02215561
119Regulation of autophagy_Homo sapiens_hsa041400.01781215
120Long-term potentiation_Homo sapiens_hsa047200.01038468
121Type II diabetes mellitus_Homo sapiens_hsa04930-0.0419713
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0164615
123Linoleic acid metabolism_Homo sapiens_hsa00591-0.0115271
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0050637

Most similar genes based on co-expression Upload to Enrichr

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