SIVA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.61890413
2ribosomal small subunit assembly (GO:0000028)5.40692992
3DNA strand elongation involved in DNA replication (GO:0006271)5.37876025
4telomere maintenance via semi-conservative replication (GO:0032201)5.34813155
5DNA strand elongation (GO:0022616)5.13996677
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.08072435
7regulation of mitochondrial translation (GO:0070129)4.85668412
8viral transcription (GO:0019083)4.81719240
9chaperone-mediated protein transport (GO:0072321)4.78917449
10DNA replication initiation (GO:0006270)4.75931708
11telomere maintenance via recombination (GO:0000722)4.74381145
12translational termination (GO:0006415)4.69500171
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.59809445
14ATP synthesis coupled proton transport (GO:0015986)4.58431299
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.58431299
16maturation of SSU-rRNA (GO:0030490)4.56154538
17ribosomal small subunit biogenesis (GO:0042274)4.45858144
18DNA replication checkpoint (GO:0000076)4.43444946
19mitotic recombination (GO:0006312)4.41045006
20deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.39258177
21translational elongation (GO:0006414)4.24544547
22CENP-A containing nucleosome assembly (GO:0034080)4.22154965
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.19115505
24chromatin remodeling at centromere (GO:0031055)4.16452920
25telomere maintenance via telomere lengthening (GO:0010833)4.16195156
26protein complex biogenesis (GO:0070271)4.14787354
27cotranslational protein targeting to membrane (GO:0006613)4.08192264
28protein targeting to ER (GO:0045047)4.06266194
29mitochondrial respiratory chain complex assembly (GO:0033108)4.01581937
30DNA unwinding involved in DNA replication (GO:0006268)4.00776797
31nucleotide-excision repair, DNA gap filling (GO:0006297)4.00663915
32respiratory electron transport chain (GO:0022904)3.99295014
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96737161
34ribosomal large subunit biogenesis (GO:0042273)3.94063866
35translational initiation (GO:0006413)3.93797097
36proteasome assembly (GO:0043248)3.91454128
37pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.89678542
38electron transport chain (GO:0022900)3.88388294
39nucleobase biosynthetic process (GO:0046112)3.87791177
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.87474532
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.87474532
42NADH dehydrogenase complex assembly (GO:0010257)3.87474532
43pyrimidine nucleotide catabolic process (GO:0006244)3.85222249
44protein targeting to mitochondrion (GO:0006626)3.84267179
45establishment of protein localization to endoplasmic reticulum (GO:0072599)3.84229151
46protein localization to endoplasmic reticulum (GO:0070972)3.82893167
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.79237333
48formation of translation preinitiation complex (GO:0001731)3.78942129
49mitotic metaphase plate congression (GO:0007080)3.75207540
50DNA replication-independent nucleosome organization (GO:0034724)3.73431540
51DNA replication-independent nucleosome assembly (GO:0006336)3.73431540
52deoxyribonucleotide catabolic process (GO:0009264)3.71614676
53ribonucleoprotein complex biogenesis (GO:0022613)3.70260982
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.69627727
55viral life cycle (GO:0019058)3.69589482
56purine nucleobase biosynthetic process (GO:0009113)3.65986533
57cellular protein complex disassembly (GO:0043624)3.65832745
58pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.64133049
59transcription-coupled nucleotide-excision repair (GO:0006283)3.63729965
60pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.60022157
61establishment of protein localization to mitochondrion (GO:0072655)3.58073650
62regulation of cellular amino acid metabolic process (GO:0006521)3.57673307
63deoxyribose phosphate catabolic process (GO:0046386)3.56803833
64deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.53569747
65respiratory chain complex IV assembly (GO:0008535)3.52955165
66pseudouridine synthesis (GO:0001522)3.51672316
67base-excision repair, AP site formation (GO:0006285)3.51484629
68DNA replication-dependent nucleosome organization (GO:0034723)3.51089735
69DNA replication-dependent nucleosome assembly (GO:0006335)3.51089735
70spliceosomal snRNP assembly (GO:0000387)3.50650719
71rRNA modification (GO:0000154)3.50313657
72establishment of viral latency (GO:0019043)3.50163501
73cytochrome complex assembly (GO:0017004)3.49371876
74kinetochore organization (GO:0051383)3.49279378
75protein localization to kinetochore (GO:0034501)3.49158546
76kinetochore assembly (GO:0051382)3.47969120
77GTP biosynthetic process (GO:0006183)3.46991885
78protein localization to mitochondrion (GO:0070585)3.44247062
79rRNA processing (GO:0006364)3.41347463
80oxidative phosphorylation (GO:0006119)3.41040206
81signal transduction involved in DNA damage checkpoint (GO:0072422)3.40198714
82translation (GO:0006412)3.39798710
83UTP biosynthetic process (GO:0006228)3.39665995
84ribosome biogenesis (GO:0042254)3.37774961
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36413070
86histone exchange (GO:0043486)3.35931797
87signal transduction involved in cell cycle checkpoint (GO:0072395)3.33620850
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.33322608
89guanosine-containing compound biosynthetic process (GO:1901070)3.32637932
90anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.31611788
91transcription elongation from RNA polymerase III promoter (GO:0006385)3.29706244
92termination of RNA polymerase III transcription (GO:0006386)3.29706244
93rRNA metabolic process (GO:0016072)3.28555568
94folic acid-containing compound biosynthetic process (GO:0009396)3.28464144
95metaphase plate congression (GO:0051310)3.27678931
96protein complex disassembly (GO:0043241)3.27563825
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.27504435
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.27504435
99protein maturation by protein folding (GO:0022417)3.26940573
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.26755962
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.26407745
102purine deoxyribonucleotide catabolic process (GO:0009155)3.25242765
103regulation of double-strand break repair via homologous recombination (GO:0010569)3.24709363
104spliceosomal complex assembly (GO:0000245)3.21677739
105CTP biosynthetic process (GO:0006241)3.20639724
106CTP metabolic process (GO:0046036)3.20639724
107establishment of integrated proviral latency (GO:0075713)3.20540608
108nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.20374962
109peptidyl-histidine modification (GO:0018202)3.18427366
110positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18409669
111cell cycle G1/S phase transition (GO:0044843)3.14031087
112G1/S transition of mitotic cell cycle (GO:0000082)3.14031087
113ribosome assembly (GO:0042255)3.13069239
114protein localization to chromosome, centromeric region (GO:0071459)3.12924932
115nuclear-transcribed mRNA catabolic process (GO:0000956)3.11893804
116macromolecular complex disassembly (GO:0032984)3.11348993
117deoxyribonucleotide biosynthetic process (GO:0009263)3.09786484
1187-methylguanosine mRNA capping (GO:0006370)3.09556544
119IMP biosynthetic process (GO:0006188)3.09412937
120mitotic nuclear envelope disassembly (GO:0007077)3.07799697
121negative regulation of ligase activity (GO:0051352)3.07687835
122negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07687835
123telomere organization (GO:0032200)3.05801691
124telomere maintenance (GO:0000723)3.04483513
1257-methylguanosine RNA capping (GO:0009452)3.04412754
126RNA capping (GO:0036260)3.04412754
127attachment of spindle microtubules to kinetochore (GO:0008608)3.00901844
128mRNA catabolic process (GO:0006402)2.97539912
129cellular component biogenesis (GO:0044085)2.96773955
130DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.96264616
131viral mRNA export from host cell nucleus (GO:0046784)2.96048932
132establishment of chromosome localization (GO:0051303)2.95663425
133mismatch repair (GO:0006298)2.92638580
134maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.92559434
135intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92524699
136signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92524699
137pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92218623
138RNA catabolic process (GO:0006401)2.91338462
139signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91189371
140signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91189371
141signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91189371
142maturation of 5.8S rRNA (GO:0000460)2.85336697
143signal transduction involved in DNA integrity checkpoint (GO:0072401)2.84840853

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.41331280
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.43805270
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.89673278
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62537698
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41261359
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.24156050
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.20958009
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14801446
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.14316185
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.04393190
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03907563
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.96942545
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94449786
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.86391973
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.81168879
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.59377549
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51705449
18XRN2_22483619_ChIP-Seq_HELA_Human2.41836680
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40138508
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37733928
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35698886
22VDR_23849224_ChIP-Seq_CD4+_Human2.32147033
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26184885
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20287027
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09052307
26DCP1A_22483619_ChIP-Seq_HELA_Human2.08866070
27FOXP3_21729870_ChIP-Seq_TREG_Human1.99418555
28GABP_19822575_ChIP-Seq_HepG2_Human1.98059570
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96985383
30AR_21909140_ChIP-Seq_LNCAP_Human1.93792719
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.90975943
32TTF2_22483619_ChIP-Seq_HELA_Human1.87786562
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87130373
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85685911
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84320600
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78972913
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.77996789
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76224107
39* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74896025
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74510753
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69644426
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69530951
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69050199
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68084807
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.66302668
46ELK1_19687146_ChIP-ChIP_HELA_Human1.62015207
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60361187
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59910333
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58712768
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57403839
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50857763
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.49606532
53ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46047460
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45722963
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42939937
56CIITA_25753668_ChIP-Seq_RAJI_Human1.41428530
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38418619
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38284463
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33907533
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32010451
61KDM5A_27292631_Chip-Seq_BREAST_Human1.28858481
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26908998
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26484704
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22143454
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.17087014
66* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15611305
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.14931484
68MYC_22102868_ChIP-Seq_BL_Human1.14897006
69* FOXP1_21924763_ChIP-Seq_HESCs_Human1.13610894
70MYC_18940864_ChIP-ChIP_HL60_Human1.12115266
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11412379
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10954699
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09233043
74* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07949732
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07498300
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07273144
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05166243
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05138929
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.04573109
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04550959
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03922600
82TP63_19390658_ChIP-ChIP_HaCaT_Human1.01487223
83SPI1_23547873_ChIP-Seq_NB4_Human1.01140377
84TFEB_21752829_ChIP-Seq_HELA_Human1.01086217
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00509682
86SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00245151
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99536927
88EGR1_19374776_ChIP-ChIP_THP-1_Human0.98371083
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96495435
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96374818
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95917900
92* VDR_21846776_ChIP-Seq_THP-1_Human0.94186374
93ZNF263_19887448_ChIP-Seq_K562_Human0.93733385
94CTCF_26484167_Chip-Seq_Bcells_Mouse0.92442964
95ELF1_20517297_ChIP-Seq_JURKAT_Human0.91606753
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88872989
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86578658
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86386691
99SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83641522
100BCL6_27268052_Chip-Seq_Bcells_Human0.83331591
101RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83232460
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83132532
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83079408
104P68_20966046_ChIP-Seq_HELA_Human0.80919165
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80600117
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80004449
107* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79564135
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77933428
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77306902
110TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76145723
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75738780
112CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75569087
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74153080
114GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74038912

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.64030925
2MP0010094_abnormal_chromosome_stability4.54248259
3MP0004957_abnormal_blastocyst_morpholog4.50729661
4MP0003111_abnormal_nucleus_morphology4.17888842
5MP0003077_abnormal_cell_cycle4.02311518
6MP0008057_abnormal_DNA_replication3.60696954
7MP0008058_abnormal_DNA_repair3.40101388
8MP0008007_abnormal_cellular_replicative2.93845822
9MP0008932_abnormal_embryonic_tissue2.73373762
10MP0002396_abnormal_hematopoietic_system2.65482684
11MP0003123_paternal_imprinting2.10729556
12MP0003786_premature_aging2.06609794
13MP0000490_abnormal_crypts_of2.05320091
14MP0008877_abnormal_DNA_methylation2.00584359
15MP0000350_abnormal_cell_proliferation1.98694579
16MP0009379_abnormal_foot_pigmentation1.92966428
17MP0001730_embryonic_growth_arrest1.86619085
18MP0003718_maternal_effect1.84950498
19MP0003186_abnormal_redox_activity1.71986590
20MP0009697_abnormal_copulation1.68082883
21MP0003806_abnormal_nucleotide_metabolis1.66495301
22MP0006292_abnormal_olfactory_placode1.66475397
23MP0008995_early_reproductive_senescence1.61930537
24MP0001764_abnormal_homeostasis1.56821605
25MP0002019_abnormal_tumor_incidence1.52974223
26MP0000313_abnormal_cell_death1.49438530
27MP0010352_gastrointestinal_tract_polyps1.47817996
28MP0002234_abnormal_pharynx_morphology1.46356485
29MP0009333_abnormal_splenocyte_physiolog1.45952879
30MP0005397_hematopoietic_system_phenotyp1.45545325
31MP0001545_abnormal_hematopoietic_system1.45545325
32MP0004808_abnormal_hematopoietic_stem1.44892628
33MP0001697_abnormal_embryo_size1.44233418
34MP0010030_abnormal_orbit_morphology1.41031129
35MP0003315_abnormal_perineum_morphology1.34542639
36MP0001672_abnormal_embryogenesis/_devel1.32546281
37MP0005380_embryogenesis_phenotype1.32546281
38MP0002080_prenatal_lethality1.32171759
39MP0006054_spinal_hemorrhage1.29880985
40MP0003763_abnormal_thymus_physiology1.26084831
41MP0002132_abnormal_respiratory_system1.25906088
42MP0002210_abnormal_sex_determination1.22797996
43MP0002085_abnormal_embryonic_tissue1.22283860
44MP0010307_abnormal_tumor_latency1.19298787
45MP0001853_heart_inflammation1.16680591
46MP0003984_embryonic_growth_retardation1.15949268
47MP0001346_abnormal_lacrimal_gland1.15661372
48MP0003567_abnormal_fetal_cardiomyocyte1.11966140
49MP0002160_abnormal_reproductive_system1.11882766
50MP0002088_abnormal_embryonic_growth/wei1.11429561
51MP0000858_altered_metastatic_potential1.11388384
52MP0005501_abnormal_skin_physiology1.09237934
53MP0002398_abnormal_bone_marrow1.08575084
54MP0003646_muscle_fatigue1.07984713
55MP0006036_abnormal_mitochondrial_physio1.07622342
56MP0005670_abnormal_white_adipose1.07440346
57MP0001145_abnormal_male_reproductive1.05402628
58MP0005075_abnormal_melanosome_morpholog1.03964310
59MP0002722_abnormal_immune_system1.02320029
60MP0000689_abnormal_spleen_morphology1.01764935
61MP0002102_abnormal_ear_morphology1.00813409
62MP0005330_cardiomyopathy1.00573375
63MP0001119_abnormal_female_reproductive0.99064627
64MP0005174_abnormal_tail_pigmentation0.98666773
65MP0001293_anophthalmia0.97815419
66MP0000358_abnormal_cell_content/0.97094937
67MP0005379_endocrine/exocrine_gland_phen0.96984369
68MP0002086_abnormal_extraembryonic_tissu0.96946911
69MP0000653_abnormal_sex_gland0.95929192
70MP0005084_abnormal_gallbladder_morpholo0.95919225
71MP0002084_abnormal_developmental_patter0.95211808
72MP0000703_abnormal_thymus_morphology0.94681915
73MP0001929_abnormal_gametogenesis0.93790581
74MP0002938_white_spotting0.92392370
75MP0001727_abnormal_embryo_implantation0.91085481
76MP0005499_abnormal_olfactory_system0.90703806
77MP0005394_taste/olfaction_phenotype0.90703806
78MP0002429_abnormal_blood_cell0.90554372
79MP0004133_heterotaxia0.88475791
80MP0005389_reproductive_system_phenotype0.87644515
81MP0002095_abnormal_skin_pigmentation0.85730618
82MP0004147_increased_porphyrin_level0.85216739
83MP0001661_extended_life_span0.83885126
84MP0002249_abnormal_larynx_morphology0.83701088
85MP0001835_abnormal_antigen_presentation0.82430864
86MP0008875_abnormal_xenobiotic_pharmacok0.82150948
87MP0004185_abnormal_adipocyte_glucose0.81959346
88MP0003698_abnormal_male_reproductive0.81649343
89MP0002653_abnormal_ependyma_morphology0.80957343
90MP0009672_abnormal_birth_weight0.77273991
91MP0006035_abnormal_mitochondrial_morpho0.76365146
92MP0004197_abnormal_fetal_growth/weight/0.76309601
93MP0005360_urolithiasis0.75879676
94MP0001529_abnormal_vocalization0.74742417
95MP0005408_hypopigmentation0.74574460
96MP0000716_abnormal_immune_system0.74363183
97MP0003941_abnormal_skin_development0.72460116
98MP0005410_abnormal_fertilization0.71165064
99MP0003121_genomic_imprinting0.71160774
100MP0002277_abnormal_respiratory_mucosa0.69934697
101MP0000678_abnormal_parathyroid_gland0.69014554
102MP0003890_abnormal_embryonic-extraembry0.68796175
103MP0003011_delayed_dark_adaptation0.67954239
104MP0005332_abnormal_amino_acid0.67621702
105MP0002163_abnormal_gland_morphology0.67367164
106MP0005384_cellular_phenotype0.67176414
107MP0009785_altered_susceptibility_to0.67021028
108MP0003656_abnormal_erythrocyte_physiolo0.66589676
109MP0002161_abnormal_fertility/fecundity0.66282233
110MP0005319_abnormal_enzyme/_coenzyme0.65726053
111MP0001881_abnormal_mammary_gland0.65469620
112MP0002111_abnormal_tail_morphology0.65420577
113MP0000477_abnormal_intestine_morphology0.65375581
114MP0005671_abnormal_response_to0.64971685
115MP0008789_abnormal_olfactory_epithelium0.64416551
116MP0000566_synostosis0.64279500
117MP0003937_abnormal_limbs/digits/tail_de0.63502295
118MP0000015_abnormal_ear_pigmentation0.63355948
119MP0002405_respiratory_system_inflammati0.62957659
120MP0005451_abnormal_body_composition0.62765346
121MP0005266_abnormal_metabolism0.62691684
122MP0003699_abnormal_female_reproductive0.62190647
123MP0000049_abnormal_middle_ear0.61620198
124MP0003136_yellow_coat_color0.60866056
125MP0001905_abnormal_dopamine_level0.60369454
126MP0002420_abnormal_adaptive_immunity0.60313601
127MP0003119_abnormal_digestive_system0.60038094
128MP0001819_abnormal_immune_cell0.59042128
129MP0008873_increased_physiological_sensi0.58352223
130MP0005621_abnormal_cell_physiology0.58261934
131MP0000372_irregular_coat_pigmentation0.58161812
132MP0002006_tumorigenesis0.58082949
133MP0002837_dystrophic_cardiac_calcinosis0.55296187
134MP0000681_abnormal_thyroid_gland0.54341646
135MP0005220_abnormal_exocrine_pancreas0.53198041
136MP0008260_abnormal_autophagy0.52213756

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.62905871
2Abnormal number of erythroid precursors (HP:0012131)5.45057570
3Reticulocytopenia (HP:0001896)5.26696140
4Birth length less than 3rd percentile (HP:0003561)5.11568511
5Acute encephalopathy (HP:0006846)5.01109900
6Aplastic anemia (HP:0001915)4.30707771
7Progressive macrocephaly (HP:0004481)4.28305073
8Oral leukoplakia (HP:0002745)4.05189211
9Breast hypoplasia (HP:0003187)3.89398828
10Cerebral edema (HP:0002181)3.73317529
11Chromsome breakage (HP:0040012)3.67541058
12Macrocytic anemia (HP:0001972)3.63186001
13Renal Fanconi syndrome (HP:0001994)3.50302802
14Lactic acidosis (HP:0003128)3.48252957
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46430715
16Pallor (HP:0000980)3.45589509
17Increased muscle lipid content (HP:0009058)3.44228646
18Colon cancer (HP:0003003)3.15131788
19Patellar aplasia (HP:0006443)3.11217414
20Rough bone trabeculation (HP:0100670)3.10893109
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.08110428
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.08110428
23Respiratory failure (HP:0002878)3.05628766
24Meckel diverticulum (HP:0002245)3.04032302
25Testicular atrophy (HP:0000029)3.03231670
26Abnormality of the preputium (HP:0100587)2.98001643
27Aplasia/Hypoplasia of the patella (HP:0006498)2.95792701
28Selective tooth agenesis (HP:0001592)2.94430918
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.93047567
30Microretrognathia (HP:0000308)2.92314575
31Abnormality of chromosome stability (HP:0003220)2.92259341
32Abnormality of the ileum (HP:0001549)2.90876672
33Type I transferrin isoform profile (HP:0003642)2.83337246
34Thrombocytosis (HP:0001894)2.75424793
35Carpal bone hypoplasia (HP:0001498)2.72961641
36Absent thumb (HP:0009777)2.70659692
37Premature graying of hair (HP:0002216)2.68963680
3811 pairs of ribs (HP:0000878)2.68180354
39Degeneration of anterior horn cells (HP:0002398)2.66785371
40Abnormality of the anterior horn cell (HP:0006802)2.66785371
41Cerebral hypomyelination (HP:0006808)2.62704569
42Pancytopenia (HP:0001876)2.61923864
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60922615
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.60334639
45Exertional dyspnea (HP:0002875)2.58375469
46Progressive muscle weakness (HP:0003323)2.57840833
47Increased serum pyruvate (HP:0003542)2.54781325
48Hepatocellular necrosis (HP:0001404)2.53171069
49Bone marrow hypocellularity (HP:0005528)2.52616428
50Increased hepatocellular lipid droplets (HP:0006565)2.52395633
51Poor head control (HP:0002421)2.48720534
52Myelodysplasia (HP:0002863)2.48092769
53Multiple enchondromatosis (HP:0005701)2.47984299
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43341507
55Abnormality of glycolysis (HP:0004366)2.42572022
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.42020314
57Increased serum lactate (HP:0002151)2.40910757
58Medulloblastoma (HP:0002885)2.40159511
59Ragged-red muscle fibers (HP:0003200)2.39010166
60Dicarboxylic aciduria (HP:0003215)2.38476653
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38476653
62Mitochondrial inheritance (HP:0001427)2.37866426
63Agnosia (HP:0010524)2.36955806
64Hepatic necrosis (HP:0002605)2.36868726
653-Methylglutaconic aciduria (HP:0003535)2.36219145
66Muscle fiber atrophy (HP:0100295)2.34511312
67Secondary amenorrhea (HP:0000869)2.32545344
68Duodenal stenosis (HP:0100867)2.32137557
69Small intestinal stenosis (HP:0012848)2.32137557
70Cleft eyelid (HP:0000625)2.30770789
71Lethargy (HP:0001254)2.30482325
72Acute necrotizing encephalopathy (HP:0006965)2.29864118
73Leukodystrophy (HP:0002415)2.28495885
74Triphalangeal thumb (HP:0001199)2.27813219
75Increased CSF lactate (HP:0002490)2.26014608
76Neoplasm of the pancreas (HP:0002894)2.25672849
77Cellular immunodeficiency (HP:0005374)2.24714490
78Trismus (HP:0000211)2.23404117
79Abnormal trabecular bone morphology (HP:0100671)2.22960435
80Lipid accumulation in hepatocytes (HP:0006561)2.20673064
81Methylmalonic aciduria (HP:0012120)2.18889668
82Absent radius (HP:0003974)2.17715492
83Tracheoesophageal fistula (HP:0002575)2.17259999
84IgM deficiency (HP:0002850)2.16457248
85Optic disc pallor (HP:0000543)2.16256817
86Abnormal mitochondria in muscle tissue (HP:0008316)2.15680451
87Abnormal number of incisors (HP:0011064)2.15223869
88Horseshoe kidney (HP:0000085)2.14385763
89CNS demyelination (HP:0007305)2.08827307
90Abnormal lung lobation (HP:0002101)2.06665646
91Type 2 muscle fiber atrophy (HP:0003554)2.05409753
92Progressive microcephaly (HP:0000253)2.04642379
93Opisthotonus (HP:0002179)2.04176719
94Sloping forehead (HP:0000340)2.03763868
95Hyperglycinemia (HP:0002154)2.03202287
96Emotional lability (HP:0000712)2.02529565
97Duplicated collecting system (HP:0000081)2.01611610
98Absent forearm bone (HP:0003953)2.00217246
99Aplasia involving forearm bones (HP:0009822)2.00217246
100Increased intramyocellular lipid droplets (HP:0012240)1.99759047
101Slender long bone (HP:0003100)1.98782104
102Abnormal protein glycosylation (HP:0012346)1.98087955
103Abnormal glycosylation (HP:0012345)1.98087955
104Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.98087955
105Abnormal protein N-linked glycosylation (HP:0012347)1.98087955
106Abnormality of the renal collecting system (HP:0004742)1.97276046
107Hypoplasia of the radius (HP:0002984)1.96942020
108Supernumerary spleens (HP:0009799)1.96880853
109Reduced antithrombin III activity (HP:0001976)1.96849637
110Pulmonary fibrosis (HP:0002206)1.96161386
111Premature ovarian failure (HP:0008209)1.96035763
112Abnormal spermatogenesis (HP:0008669)1.95637142
113Abnormality of renal resorption (HP:0011038)1.94536072
114Lymphoma (HP:0002665)1.92703782
115Facial cleft (HP:0002006)1.91122349
116Respiratory difficulties (HP:0002880)1.90691819
117Atresia of the external auditory canal (HP:0000413)1.89526143
118Microvesicular hepatic steatosis (HP:0001414)1.89172697
119Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88401146
120Sparse eyelashes (HP:0000653)1.87261253
121Abnormality of the duodenum (HP:0002246)1.87047604
122Abnormality of reticulocytes (HP:0004312)1.84229324
123Petechiae (HP:0000967)1.83985208
124Exercise intolerance (HP:0003546)1.83817749
125Clubbing of toes (HP:0100760)1.81898603
126Broad distal phalanx of finger (HP:0009836)1.80294105
127Generalized aminoaciduria (HP:0002909)1.78376388
128Sclerocornea (HP:0000647)1.72655744
129Hypoplastic pelvis (HP:0008839)1.69767360
130Abnormality of the umbilical cord (HP:0010881)1.65662902
131Cerebral palsy (HP:0100021)1.65195353
132X-linked dominant inheritance (HP:0001423)1.64722493
133Abnormality of urine glucose concentration (HP:0011016)1.64648476
134Glycosuria (HP:0003076)1.64648476
135Squamous cell carcinoma (HP:0002860)1.64593496
136Gliosis (HP:0002171)1.63736441
137Abnormality of DNA repair (HP:0003254)1.61434552
138Abnormal umbilical cord blood vessels (HP:0011403)1.61228632
139Single umbilical artery (HP:0001195)1.61228632
140Abnormality of the fetal cardiovascular system (HP:0010948)1.61228632
141Hypergonadotropic hypogonadism (HP:0000815)1.61138091
142Hypoplasia of the pons (HP:0012110)1.60906551
143Hyperalaninemia (HP:0003348)1.58820679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.17601254
2BUB14.52502565
3WEE14.44024640
4CDC73.72031647
5NME23.32025808
6EIF2AK13.18825971
7STK162.82519967
8PLK42.74450513
9VRK12.65187827
10SRPK12.45183750
11ACVR1B2.35786838
12EIF2AK32.29811040
13TLK12.14632206
14BRSK22.08455904
15TTK1.99900954
16NEK21.99055337
17RPS6KA41.94123002
18SMG11.90287005
19PLK11.85417914
20TESK21.80275204
21TAF11.76946923
22CDK71.73765318
23PIM21.70100877
24AURKB1.61770562
25CDK81.58041064
26DYRK31.57910078
27MKNK11.55088029
28NUAK11.54460858
29ATR1.53031223
30TSSK61.47955173
31RPS6KB21.47332810
32CCNB11.41206200
33NEK11.39046512
34BRSK11.34977335
35CHEK21.34235705
36AURKA1.25111737
37MAP3K81.24911676
38BRAF1.23241703
39MKNK21.21711285
40PASK1.20806822
41DAPK11.20436043
42ZAK1.14898192
43SCYL21.12596938
44LIMK11.08850542
45PLK31.08302064
46BCKDK1.04171132
47CDK41.02487034
48KDR1.02286911
49CSNK1G31.01982801
50PDK21.01638948
51PAK41.01425690
52PBK0.98232099
53STK40.93540220
54TRIM280.92850748
55PIM10.92683025
56EIF2AK20.91380443
57TGFBR10.90950221
58EPHA20.90579414
59CHEK10.89750024
60STK100.82529189
61MAP3K110.81904890
62IRAK40.81097303
63NME10.80986521
64CSNK2A10.76688630
65TEC0.73995593
66MAP4K20.73542550
67ARAF0.73449435
68INSRR0.73177508
69CSNK1G10.72687552
70FLT30.71120369
71TESK10.70223420
72RPS6KA50.69915902
73PAK10.68869385
74CDK190.68453757
75LRRK20.68062950
76CSNK1A1L0.67984270
77CSNK2A20.67525137
78DYRK20.65266576
79MAP2K30.65039925
80KIT0.63979946
81MAPKAPK30.62117694
82ATM0.61171824
83STK38L0.61139814
84* ABL20.61088543
85DAPK30.60328209
86CDK20.59914780
87BTK0.59396562
88IRAK30.57733629
89CSNK1G20.55651429
90MAP4K10.54835475
91MAP3K60.54798187
92ILK0.51745358
93PRKCI0.49380601
94MAPK110.49021061
95MUSK0.47175469
96RAF10.43281315
97MAPKAPK50.41909286
98EEF2K0.41215755
99CDK10.41034762
100IKBKB0.39828910
101IRAK20.39297329
102TAOK20.38029379
103MAP3K30.36809360
104BLK0.36352617
105LATS20.35224728
106BMPR1B0.34281769
107CDK90.33622982
108TRIB30.33415134
109MELK0.32977295
110YES10.32296736
111NLK0.32004686
112MAP3K120.31713580
113JAK30.30536788
114CLK10.30148001
115TBK10.29748994
116MST40.29355575
117NEK90.29313668
118GRK50.27385673
119GRK60.27296114
120MAP2K70.26994740
121LYN0.25237076
122AKT20.25127196
123TNK20.24360676
124CSF1R0.23794040
125MAP2K20.23412949
126MATK0.20158344
127RPS6KA60.20125424
128MAP2K60.18987351
129ERN10.16009853

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.39008616
2Ribosome_Homo sapiens_hsa030104.43391024
3Mismatch repair_Homo sapiens_hsa034304.41895655
4Proteasome_Homo sapiens_hsa030503.50878574
5RNA polymerase_Homo sapiens_hsa030203.50308221
6Homologous recombination_Homo sapiens_hsa034403.42718914
7Base excision repair_Homo sapiens_hsa034103.10794064
8Spliceosome_Homo sapiens_hsa030403.04397789
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03578551
10Nucleotide excision repair_Homo sapiens_hsa034202.95046404
11Pyrimidine metabolism_Homo sapiens_hsa002402.86751974
12RNA transport_Homo sapiens_hsa030132.46902325
13Cell cycle_Homo sapiens_hsa041102.45656485
14Fanconi anemia pathway_Homo sapiens_hsa034602.21548931
15One carbon pool by folate_Homo sapiens_hsa006702.14424889
16RNA degradation_Homo sapiens_hsa030181.96653153
17Basal transcription factors_Homo sapiens_hsa030221.90150569
18Non-homologous end-joining_Homo sapiens_hsa034501.87652781
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73866425
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61084656
21Protein export_Homo sapiens_hsa030601.55945152
22Purine metabolism_Homo sapiens_hsa002301.53993277
23Fatty acid elongation_Homo sapiens_hsa000621.53693069
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51756763
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.50632208
26p53 signaling pathway_Homo sapiens_hsa041151.45582115
27Parkinsons disease_Homo sapiens_hsa050121.31862230
28Huntingtons disease_Homo sapiens_hsa050161.25501430
29Oxidative phosphorylation_Homo sapiens_hsa001901.24767760
30Folate biosynthesis_Homo sapiens_hsa007901.22242696
31mRNA surveillance pathway_Homo sapiens_hsa030151.10943877
32Epstein-Barr virus infection_Homo sapiens_hsa051691.00417055
33Pyruvate metabolism_Homo sapiens_hsa006200.98686488
34Cardiac muscle contraction_Homo sapiens_hsa042600.97823392
35Sulfur relay system_Homo sapiens_hsa041220.93050135
36Systemic lupus erythematosus_Homo sapiens_hsa053220.91434324
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91043960
38Pentose phosphate pathway_Homo sapiens_hsa000300.87619601
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87427716
40Herpes simplex infection_Homo sapiens_hsa051680.87141959
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86271020
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.81736211
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.75335859
44Glutathione metabolism_Homo sapiens_hsa004800.75026703
45Sulfur metabolism_Homo sapiens_hsa009200.72701133
46Propanoate metabolism_Homo sapiens_hsa006400.71410033
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70730044
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67330153
49Antigen processing and presentation_Homo sapiens_hsa046120.66285850
50Peroxisome_Homo sapiens_hsa041460.61781857
51Alzheimers disease_Homo sapiens_hsa050100.61369615
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60232176
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59330276
54Oocyte meiosis_Homo sapiens_hsa041140.59062607
55N-Glycan biosynthesis_Homo sapiens_hsa005100.57077568
56Viral carcinogenesis_Homo sapiens_hsa052030.56915189
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54505342
58HTLV-I infection_Homo sapiens_hsa051660.53570427
59Biosynthesis of amino acids_Homo sapiens_hsa012300.52768850
60Thyroid cancer_Homo sapiens_hsa052160.51472896
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50920071
62Phenylalanine metabolism_Homo sapiens_hsa003600.50152688
63Legionellosis_Homo sapiens_hsa051340.48820992
64Selenocompound metabolism_Homo sapiens_hsa004500.44167053
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43836702
66Tyrosine metabolism_Homo sapiens_hsa003500.43596398
67Galactose metabolism_Homo sapiens_hsa000520.40083018
68Metabolic pathways_Homo sapiens_hsa011000.39277651
69Primary immunodeficiency_Homo sapiens_hsa053400.38536312
70Small cell lung cancer_Homo sapiens_hsa052220.38426601
71Apoptosis_Homo sapiens_hsa042100.37797331
72Arachidonic acid metabolism_Homo sapiens_hsa005900.37767647
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37531290
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37367810
75Vitamin B6 metabolism_Homo sapiens_hsa007500.36243918
76Fatty acid metabolism_Homo sapiens_hsa012120.34650392
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34097379
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32753197
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32632786
80Fatty acid degradation_Homo sapiens_hsa000710.32067637
81Carbon metabolism_Homo sapiens_hsa012000.31147228
82Fructose and mannose metabolism_Homo sapiens_hsa000510.30478501
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29827043
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29471005
85Shigellosis_Homo sapiens_hsa051310.28739430
86Measles_Homo sapiens_hsa051620.28486866
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28023563
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27478479
89TGF-beta signaling pathway_Homo sapiens_hsa043500.27006567
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.26303064
91Other glycan degradation_Homo sapiens_hsa005110.25065029
92Hepatitis B_Homo sapiens_hsa051610.24655574
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24208020
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.23665760
95Bladder cancer_Homo sapiens_hsa052190.22687022
96Hematopoietic cell lineage_Homo sapiens_hsa046400.22421813
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21904225
98Alcoholism_Homo sapiens_hsa050340.21124997
99MicroRNAs in cancer_Homo sapiens_hsa052060.21095781
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20769162
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.18840250
102beta-Alanine metabolism_Homo sapiens_hsa004100.18592863
103Butanoate metabolism_Homo sapiens_hsa006500.18323612
104Tryptophan metabolism_Homo sapiens_hsa003800.17548281
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17474536
106Chemical carcinogenesis_Homo sapiens_hsa052040.17388589
107Linoleic acid metabolism_Homo sapiens_hsa005910.16751769
108Vitamin digestion and absorption_Homo sapiens_hsa049770.16372125
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.16189641
110Influenza A_Homo sapiens_hsa051640.15006443
111Fat digestion and absorption_Homo sapiens_hsa049750.14697072
112Steroid biosynthesis_Homo sapiens_hsa001000.14522519
113Basal cell carcinoma_Homo sapiens_hsa052170.14292624
114Regulation of autophagy_Homo sapiens_hsa041400.14013397
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13945937
116Arginine and proline metabolism_Homo sapiens_hsa003300.12899768
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12788329
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12101011
119Leishmaniasis_Homo sapiens_hsa051400.11728405
120Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.11689855
121Pathways in cancer_Homo sapiens_hsa052000.09359357
122Asthma_Homo sapiens_hsa053100.09017669
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08821983
124Colorectal cancer_Homo sapiens_hsa052100.08761804
125Allograft rejection_Homo sapiens_hsa053300.08672573
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08662950
127Hippo signaling pathway_Homo sapiens_hsa043900.08476749
128Arginine biosynthesis_Homo sapiens_hsa002200.08403196
129Vibrio cholerae infection_Homo sapiens_hsa051100.08266265
130Acute myeloid leukemia_Homo sapiens_hsa052210.07639965
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07166678

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