SIX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1outer ear morphogenesis (GO:0042473)5.24870969
2* skeletal muscle tissue development (GO:0007519)5.20865290
3regulation of skeletal muscle contraction (GO:0014819)5.17479198
4response to muscle activity (GO:0014850)4.94532589
5negative regulation of fatty acid transport (GO:2000192)4.84867288
6* middle ear morphogenesis (GO:0042474)4.62889021
7plasma membrane repair (GO:0001778)4.62785843
8striated muscle contraction (GO:0006941)4.55073364
9actin-myosin filament sliding (GO:0033275)4.49015964
10muscle filament sliding (GO:0030049)4.49015964
11sarcomere organization (GO:0045214)4.43888806
12myofibril assembly (GO:0030239)4.41786969
13regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.22995969
14* embryonic cranial skeleton morphogenesis (GO:0048701)4.14111891
15planar cell polarity pathway involved in neural tube closure (GO:0090179)4.13440854
16actin-mediated cell contraction (GO:0070252)4.04990928
17skeletal muscle fiber development (GO:0048741)4.02080647
18muscle cell fate commitment (GO:0042693)3.99817292
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.89850174
20skeletal muscle contraction (GO:0003009)3.89135516
21hippo signaling (GO:0035329)3.88293406
22* striated muscle tissue development (GO:0014706)3.79875465
23collagen fibril organization (GO:0030199)3.76626170
24muscle contraction (GO:0006936)3.76022385
25cardiac myofibril assembly (GO:0055003)3.71138073
26negative regulation of chondrocyte differentiation (GO:0032331)3.62974116
27* muscle tissue development (GO:0060537)3.61049393
28mitotic sister chromatid cohesion (GO:0007064)3.56221277
29regulation of relaxation of muscle (GO:1901077)3.56054909
30actomyosin structure organization (GO:0031032)3.55173099
31* regulation of cardioblast proliferation (GO:0003264)3.54903432
32* regulation of secondary heart field cardioblast proliferation (GO:0003266)3.54903432
33ganglion development (GO:0061548)3.53891620
34actin filament-based movement (GO:0030048)3.52035538
35glycogen catabolic process (GO:0005980)3.51965326
36G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.48918265
37bone trabecula formation (GO:0060346)3.47480860
38neuron projection extension involved in neuron projection guidance (GO:1902284)3.45752766
39axon extension involved in axon guidance (GO:0048846)3.45752766
40proximal/distal pattern formation (GO:0009954)3.45447600
41glycogen biosynthetic process (GO:0005978)3.45298891
42glucan biosynthetic process (GO:0009250)3.45298891
43positive regulation of myotube differentiation (GO:0010831)3.42918411
44myoblast fusion (GO:0007520)3.39184434
45muscle organ morphogenesis (GO:0048644)3.37969241
46positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.35261320
47* muscle cell migration (GO:0014812)3.33668148
48muscle system process (GO:0003012)3.31308138
49syncytium formation (GO:0006949)3.31031213
50chondrocyte proliferation (GO:0035988)3.30711296
51regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.29239258
52syncytium formation by plasma membrane fusion (GO:0000768)3.27196410
53myotube cell development (GO:0014904)3.25326083
54cardiac muscle contraction (GO:0060048)3.21364217
55muscle organ development (GO:0007517)3.19735221
56glucan catabolic process (GO:0009251)3.19206924
57* regulation of heart morphogenesis (GO:2000826)3.18942114
58face morphogenesis (GO:0060325)3.15936631
59muscle structure development (GO:0061061)3.15720302
60sequestering of extracellular ligand from receptor (GO:0035581)3.15076502
61negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.14647568
62epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.13800474
63polarized epithelial cell differentiation (GO:0030859)3.12898263
64NADH metabolic process (GO:0006734)3.12411501
65skeletal muscle adaptation (GO:0043501)3.10998813
66peripheral nervous system neuron development (GO:0048935)3.06850327
67* metanephric mesenchyme development (GO:0072075)3.05922121
68regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.05408505
69creatine metabolic process (GO:0006600)2.98868575
70extracellular fibril organization (GO:0043206)2.98775497
71* aorta morphogenesis (GO:0035909)2.98563293
72paraxial mesoderm development (GO:0048339)2.96196475
73skeletal muscle tissue regeneration (GO:0043403)2.95823856
74embryonic skeletal joint morphogenesis (GO:0060272)2.95515718
75negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.95171739
76striated muscle atrophy (GO:0014891)2.93363180
77negative regulation of cartilage development (GO:0061037)2.91308834
78cellular polysaccharide catabolic process (GO:0044247)2.88562573
79response to inactivity (GO:0014854)2.88402903
80segment specification (GO:0007379)2.88201193
81regulation of cardioblast differentiation (GO:0051890)2.88180493
82muscle atrophy (GO:0014889)2.87647565
83positive regulation of actin filament depolymerization (GO:0030836)2.85769459
84craniofacial suture morphogenesis (GO:0097094)2.84987573
85negative regulation of cell size (GO:0045792)2.84964452
86regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.84486795
87negative regulation of embryonic development (GO:0045992)2.84083070
88positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.83843332
89positive regulation of myoblast differentiation (GO:0045663)2.82661469
90endodermal cell differentiation (GO:0035987)2.82357878
91muscle tissue morphogenesis (GO:0060415)2.81726976
92* kidney mesenchyme development (GO:0072074)2.81329166
93regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.79105249
94* generation of neurons (GO:0048699)2.78983184
95striated muscle adaptation (GO:0014888)2.78270704
96embryonic forelimb morphogenesis (GO:0035115)2.77472067
97protein heterotrimerization (GO:0070208)2.77244974
98* regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.77109086
99regulation of transforming growth factor beta2 production (GO:0032909)2.76842211
100regulation of skeletal muscle cell differentiation (GO:2001014)2.76420666
101axonemal dynein complex assembly (GO:0070286)2.75344411
102forelimb morphogenesis (GO:0035136)2.72848565
103motile cilium assembly (GO:0044458)2.72271680
104AMP metabolic process (GO:0046033)2.72248594
105tricarboxylic acid cycle (GO:0006099)2.71233158
106myotube differentiation (GO:0014902)2.71201780
107bone morphogenesis (GO:0060349)2.70618952
108regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.69942385
109lymph vessel development (GO:0001945)2.69104774
110* positive regulation of mesenchymal cell proliferation (GO:0002053)2.69002757
111negative regulation of cell fate specification (GO:0009996)2.68642133
112body morphogenesis (GO:0010171)2.68549482
113mesenchyme morphogenesis (GO:0072132)2.68526929
114response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.67609161
115embryonic body morphogenesis (GO:0010172)2.64714031
116gluconeogenesis (GO:0006094)2.62726440
117striated muscle cell development (GO:0055002)2.62199423
118Golgi transport vesicle coating (GO:0048200)2.61597441
119COPI coating of Golgi vesicle (GO:0048205)2.61597441
120chondrocyte development (GO:0002063)2.61508001
121endocardial cushion development (GO:0003197)2.61114152
122muscle cell proliferation (GO:0033002)2.60894435
123Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.60865935
124negative regulation of protein localization to cell surface (GO:2000009)2.60100167
125cell-substrate adherens junction assembly (GO:0007045)2.59802688
126focal adhesion assembly (GO:0048041)2.59802688
127non-canonical Wnt signaling pathway (GO:0035567)2.58980374
128regulation of myoblast differentiation (GO:0045661)2.55759025
129convergent extension (GO:0060026)2.55205237
130hemidesmosome assembly (GO:0031581)2.55198928
131glycogen metabolic process (GO:0005977)2.54460043
132regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.54125263
133negative regulation of axon extension involved in axon guidance (GO:0048843)2.53705055
134mitotic chromosome condensation (GO:0007076)2.53459536
135* myoblast migration (GO:0051451)2.53216384
136regulation of establishment of planar polarity (GO:0090175)2.53140083
137face development (GO:0060324)2.52481738
138polysaccharide catabolic process (GO:0000272)2.52164910
139cellular response to interferon-alpha (GO:0035457)2.51536603
140positive regulation of smoothened signaling pathway (GO:0045880)2.51186687
141cardiac muscle cell development (GO:0055013)2.50392010
142* cochlea morphogenesis (GO:0090103)2.49476792
143regulation of cell communication by electrical coupling (GO:0010649)2.49013508
144mesenchymal-epithelial cell signaling (GO:0060638)2.48343340
145sarcoplasmic reticulum calcium ion transport (GO:0070296)2.48214474
146glycoprotein catabolic process (GO:0006516)2.46834669
147glucocorticoid receptor signaling pathway (GO:0042921)2.46539229
148positive regulation of skeletal muscle tissue development (GO:0048643)2.46396285
149camera-type eye morphogenesis (GO:0048593)2.45786351
150negative regulation of catenin import into nucleus (GO:0035414)2.45297216
151endocrine hormone secretion (GO:0060986)2.45078828
152* mesenchyme development (GO:0060485)2.44661038
153eye morphogenesis (GO:0048592)2.44035538
154positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.42511823
155negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.40398260
156* embryonic skeletal system morphogenesis (GO:0048704)2.40289468
157regulation of protein heterodimerization activity (GO:0043497)2.39532261
158* regulation of mesenchymal cell proliferation (GO:0010464)2.39424336
159regulation of cartilage development (GO:0061035)2.37919380
160muscle fiber development (GO:0048747)2.36879336
161muscle cell cellular homeostasis (GO:0046716)2.36221956
162notochord development (GO:0030903)2.34557854
163regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.32217051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.29548700
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.28697771
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.22444033
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.81123828
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.41504249
6E2F7_22180533_ChIP-Seq_HELA_Human3.22121385
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.06464603
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.05218912
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.87757302
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87610241
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.65455219
12CLOCK_20551151_ChIP-Seq_293T_Human2.51061640
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.43285369
14* WT1_19549856_ChIP-ChIP_CCG9911_Human2.42551168
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.34783237
16* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.29352178
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26484370
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24867716
19MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.18281505
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.09632639
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08804727
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06003186
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.04060660
24AR_21909140_ChIP-Seq_LNCAP_Human2.02606145
25NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.99296736
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97134000
27ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.95125279
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.94960051
29CJUN_26792858_Chip-Seq_BT549_Human1.94325859
30BRD4_25478319_ChIP-Seq_HGPS_Human1.90335487
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89560076
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88978501
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88090139
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83739452
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80721649
36* EED_16625203_ChIP-ChIP_MESCs_Mouse1.79310700
37ZNF263_19887448_ChIP-Seq_K562_Human1.78602501
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.76971099
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.76971099
40* TP53_20018659_ChIP-ChIP_R1E_Mouse1.76632426
41* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.73751240
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.73492909
43TP53_18474530_ChIP-ChIP_U2OS_Human1.71785876
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.68597002
45STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.67969742
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65742178
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.64967441
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.64570085
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61755453
50NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60510168
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60510168
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57847913
53SMC3_22415368_ChIP-Seq_MEFs_Mouse1.57321968
54* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56911664
55* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56911664
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.56089838
57BP1_19119308_ChIP-ChIP_Hs578T_Human1.54699692
58* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.54365508
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53588179
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52717638
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51436853
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48054950
63* UBF1/2_26484160_Chip-Seq_HMECs_Human1.46817931
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.42047762
65TP53_16413492_ChIP-PET_HCT116_Human1.35231197
66* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33007204
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32978989
68GATA4_21415370_ChIP-Seq_HL-1_Mouse1.31697742
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29748042
70* CBX2_27304074_Chip-Seq_ESCs_Mouse1.29321078
71ZNF274_21170338_ChIP-Seq_K562_Hela1.28305042
72* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28144481
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.27802626
74TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27732396
75* EZH2_27304074_Chip-Seq_ESCs_Mouse1.26725808
76DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.26275653
77* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26265694
78* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25076750
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24251872
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24034842
81SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23168677
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23094262
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.22002099
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20662388
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20178456
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19586628
87* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18954118
88FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18133966
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17458708
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.17351638
91TP53_23651856_ChIP-Seq_MEFs_Mouse1.16947744
92* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16108598
93ATF3_27146783_Chip-Seq_COLON_Human1.14678228
94* ISL1_27105846_Chip-Seq_CPCs_Mouse1.14599750
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14532376
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14439440
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14372621
98ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13647845
99SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12849773
100CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11139357
101TCF4_18268006_ChIP-ChIP_LS174T_Human1.09636058
102TET1_21451524_ChIP-Seq_MESCs_Mouse1.09500323
103* TBX20_22080862_ChIP-Seq_HEART_Mouse1.09379767
104* TBX20_22328084_ChIP-Seq_HEART_Mouse1.09379767
105HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08920575
106ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08560196
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07414059
108* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06317969
109RACK7_27058665_Chip-Seq_MCF-7_Human1.06098285
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05357691
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05237107
112TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04466946
113SA1_22415368_ChIP-Seq_MEFs_Mouse1.04364040
114AHR_22903824_ChIP-Seq_MCF-7_Human1.03230715
115KLF5_25053715_ChIP-Seq_YYC3_Human1.03122697
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01857407
117* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01275509
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01233753
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01135849
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00844609
121ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00519545
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00193423
123FOXO3_23340844_ChIP-Seq_DLD1_Human1.00172569
124FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99932380
125* SOX2_20726797_ChIP-Seq_SW620_Human0.97311650
126* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97179564
127TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97135587
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97115651
129TP53_22127205_ChIP-Seq_IMR90_Human0.96899402
130* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96687932
131* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95946837
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95431603
133* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95179236
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94084888
135* NANOG_16153702_ChIP-ChIP_HESCs_Human0.94006673
136ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93921582
137* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93757000
138EOMES_21245162_ChIP-Seq_HESCs_Human0.93412885
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93373463
140CHD1_26751641_Chip-Seq_LNCaP_Human0.92067174
141VDR_24787735_ChIP-Seq_THP-1_Human0.91922891
142MYC_18555785_ChIP-Seq_MESCs_Mouse0.91590394
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91574910
144UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91136969
145THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90968742
146PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90802709

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology3.72415388
2MP0003646_muscle_fatigue3.69402078
3MP0008438_abnormal_cutaneous_collagen3.61616403
4MP0003705_abnormal_hypodermis_morpholog3.35103324
5* MP0000733_abnormal_muscle_development3.10835700
6MP0009250_abnormal_appendicular_skeleto2.79531105
7* MP0010030_abnormal_orbit_morphology2.65431621
8MP0003950_abnormal_plasma_membrane2.63264306
9MP0004036_abnormal_muscle_relaxation2.60711075
10MP0009780_abnormal_chondrocyte_physiolo2.48396320
11MP0004145_abnormal_muscle_electrophysio2.48227570
12MP0005275_abnormal_skin_tensile2.31755336
13MP0002249_abnormal_larynx_morphology2.23186449
14MP0000749_muscle_degeneration2.13092501
15MP0003385_abnormal_body_wall2.05161882
16MP0005330_cardiomyopathy2.01479146
17MP0003937_abnormal_limbs/digits/tail_de1.98889587
18* MP0003755_abnormal_palate_morphology1.98880392
19MP0000751_myopathy1.94013548
20* MP0000049_abnormal_middle_ear1.91394145
21MP0002877_abnormal_melanocyte_morpholog1.89513783
22MP0000750_abnormal_muscle_regeneration1.88831417
23MP0002108_abnormal_muscle_morphology1.88526429
24MP0002332_abnormal_exercise_endurance1.86121772
25* MP0001346_abnormal_lacrimal_gland1.84902011
26MP0005508_abnormal_skeleton_morphology1.84002436
27MP0000678_abnormal_parathyroid_gland1.83851712
28MP0010352_gastrointestinal_tract_polyps1.83008451
29MP0004084_abnormal_cardiac_muscle1.82731488
30* MP0000759_abnormal_skeletal_muscle1.81266030
31MP0009053_abnormal_anal_canal1.78529655
32MP0004130_abnormal_muscle_cell1.75251087
33MP0002254_reproductive_system_inflammat1.74239710
34* MP0001299_abnormal_eye_distance/1.74080423
35MP0005076_abnormal_cell_differentiation1.70282969
36MP0005451_abnormal_body_composition1.67867327
37MP0002009_preneoplasia1.65928990
38* MP0003942_abnormal_urinary_system1.60433348
39* MP0000762_abnormal_tongue_morphology1.59325294
40MP0000013_abnormal_adipose_tissue1.58604096
41MP0000428_abnormal_craniofacial_morphol1.56039460
42MP0005367_renal/urinary_system_phenotyp1.55003077
43MP0000516_abnormal_urinary_system1.55003077
44* MP0004087_abnormal_muscle_fiber1.54307711
45* MP0002233_abnormal_nose_morphology1.54074852
46MP0002106_abnormal_muscle_physiology1.53899934
47MP0005623_abnormal_meninges_morphology1.53277576
48MP0005369_muscle_phenotype1.52674021
49MP0003279_aneurysm1.52296178
50* MP0002932_abnormal_joint_morphology1.51242749
51MP0001348_abnormal_lacrimal_gland1.48517908
52MP0005670_abnormal_white_adipose1.46643564
53* MP0000534_abnormal_ureter_morphology1.46490041
54MP0000003_abnormal_adipose_tissue1.46031097
55MP0000747_muscle_weakness1.45745979
56MP0009384_cardiac_valve_regurgitation1.43375696
57* MP0003935_abnormal_craniofacial_develop1.38257875
58MP0002972_abnormal_cardiac_muscle1.36980587
59MP0000537_abnormal_urethra_morphology1.34868466
60MP0002234_abnormal_pharynx_morphology1.34261502
61MP0005023_abnormal_wound_healing1.32299014
62MP0003941_abnormal_skin_development1.32039290
63MP0002896_abnormal_bone_mineralization1.31818327
64MP0001849_ear_inflammation1.31504409
65MP0003091_abnormal_cell_migration1.29359246
66MP0003566_abnormal_cell_adhesion1.27571561
67MP0005248_abnormal_Harderian_gland1.26657346
68MP0004134_abnormal_chest_morphology1.26259784
69* MP0002116_abnormal_craniofacial_bone1.25902378
70MP0004233_abnormal_muscle_weight1.22708562
71MP0002269_muscular_atrophy1.21240068
72* MP0002109_abnormal_limb_morphology1.20705756
73MP0000432_abnormal_head_morphology1.19666292
74* MP0000163_abnormal_cartilage_morphology1.19589290
75MP0002115_abnormal_skeleton_extremities1.19390942
76MP0005187_abnormal_penis_morphology1.16088136
77MP0005375_adipose_tissue_phenotype1.14781560
78MP0010307_abnormal_tumor_latency1.13930019
79MP0000681_abnormal_thyroid_gland1.13415931
80MP0001542_abnormal_bone_strength1.13087094
81* MP0008789_abnormal_olfactory_epithelium1.12693376
82MP0002971_abnormal_brown_adipose1.12126873
83MP0006036_abnormal_mitochondrial_physio1.10843353
84MP0002060_abnormal_skin_morphology1.10581866
85MP0009278_abnormal_bone_marrow1.10201063
86MP0001879_abnormal_lymphatic_vessel1.09537837
87MP0001661_extended_life_span1.08357153
88MP0004272_abnormal_basement_membrane1.05038807
89MP0006138_congestive_heart_failure1.04923920
90* MP0002114_abnormal_axial_skeleton1.02609781
91* MP0002113_abnormal_skeleton_development1.02266511
92MP0002111_abnormal_tail_morphology1.01930570
93MP0005499_abnormal_olfactory_system0.99442394
94MP0005394_taste/olfaction_phenotype0.99442394
95MP0002938_white_spotting0.97026521
96MP0004197_abnormal_fetal_growth/weight/0.96498346
97MP0005666_abnormal_adipose_tissue0.96373437
98MP0002127_abnormal_cardiovascular_syste0.95186224
99MP0002282_abnormal_trachea_morphology0.94786235
100MP0010368_abnormal_lymphatic_system0.94781938
101* MP0002177_abnormal_outer_ear0.92982370
102* MP0001270_distended_abdomen0.91988051
103MP0003453_abnormal_keratinocyte_physiol0.91750722
104MP0001958_emphysema0.91270844
105MP0005390_skeleton_phenotype0.91252658
106MP0000767_abnormal_smooth_muscle0.85989421
107MP0005377_hearing/vestibular/ear_phenot0.85403654
108MP0003878_abnormal_ear_physiology0.85403654
109MP0003315_abnormal_perineum_morphology0.85096265
110MP0002837_dystrophic_cardiac_calcinosis0.84692417
111MP0005385_cardiovascular_system_phenoty0.82729301
112MP0001544_abnormal_cardiovascular_syste0.82729301
113MP0009703_decreased_birth_body0.81383545
114MP0010630_abnormal_cardiac_muscle0.80990242
115MP0005257_abnormal_intraocular_pressure0.79096403
116MP0000383_abnormal_hair_follicle0.77998717
117MP0003828_pulmonary_edema0.76959742
118MP0002084_abnormal_developmental_patter0.76286403
119MP0003115_abnormal_respiratory_system0.74600681
120* MP0002085_abnormal_embryonic_tissue0.74448236
121MP0005620_abnormal_muscle_contractility0.74442696
122MP0004215_abnormal_myocardial_fiber0.73804152
123MP0002925_abnormal_cardiovascular_devel0.73676269
124MP0000266_abnormal_heart_morphology0.73499435
125MP0004185_abnormal_adipocyte_glucose0.72930857
126MP0008007_abnormal_cellular_replicative0.72219605
127MP0008775_abnormal_heart_ventricle0.70903885
128MP0002697_abnormal_eye_size0.70699761
129MP0002160_abnormal_reproductive_system0.68934331
130MP0003879_abnormal_hair_cell0.67845353
131MP0005266_abnormal_metabolism0.65645133
132MP0004858_abnormal_nervous_system0.64441138
133MP0002128_abnormal_blood_circulation0.62221046
134MP0005197_abnormal_uvea_morphology0.55339635
135MP0004484_altered_response_of0.54391423
136MP0000467_abnormal_esophagus_morphology0.53966016
137MP0003221_abnormal_cardiomyocyte_apopto0.53593365
138MP0004510_myositis0.52180060

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.26497163
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.20535961
3Type 1 muscle fiber predominance (HP:0003803)5.15452256
4Nemaline bodies (HP:0003798)4.69407806
5Distal arthrogryposis (HP:0005684)4.62917438
6Popliteal pterygium (HP:0009756)3.87864696
7Round ear (HP:0100830)3.78771910
8Absent phalangeal crease (HP:0006109)3.63657539
9Protrusio acetabuli (HP:0003179)3.61452231
10Neck muscle weakness (HP:0000467)3.58067342
11Premature rupture of membranes (HP:0001788)3.50203332
12Rhabdomyolysis (HP:0003201)3.50006859
13Centrally nucleated skeletal muscle fibers (HP:0003687)3.46811775
14Ulnar deviation of the wrist (HP:0003049)3.44027190
15Myoglobinuria (HP:0002913)3.42671461
16Deformed tarsal bones (HP:0008119)3.31989884
17Calcaneovalgus deformity (HP:0001848)3.31294744
18Increased connective tissue (HP:0009025)3.22121977
19Malignant hyperthermia (HP:0002047)3.14192309
20Scapular winging (HP:0003691)3.11623213
21Difficulty running (HP:0009046)3.05197494
22Shallow orbits (HP:0000586)3.00937203
23Abnormal finger flexion creases (HP:0006143)2.98228014
24Myopathic facies (HP:0002058)2.92165033
25Rimmed vacuoles (HP:0003805)2.89334179
26Hyporeflexia of lower limbs (HP:0002600)2.88769029
27Exercise-induced muscle cramps (HP:0003710)2.86207645
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.85143080
29Short 4th metacarpal (HP:0010044)2.85143080
30Muscle stiffness (HP:0003552)2.84759325
31Arterial tortuosity (HP:0005116)2.77972077
32Difficulty climbing stairs (HP:0003551)2.77921841
33Abnormality of the left ventricular outflow tract (HP:0011103)2.76809310
34Subaortic stenosis (HP:0001682)2.76809310
35Pterygium (HP:0001059)2.74513213
36Asymmetric septal hypertrophy (HP:0001670)2.70176683
37Vascular tortuosity (HP:0004948)2.70026340
38Microglossia (HP:0000171)2.64880488
39Limb-girdle muscle atrophy (HP:0003797)2.63768238
40Fatigable weakness (HP:0003473)2.63436922
41Abnormality of the neuromuscular junction (HP:0003398)2.63436922
42Infantile muscular hypotonia (HP:0008947)2.62383317
43Pelvic girdle muscle weakness (HP:0003749)2.60964771
44Muscle fiber splitting (HP:0003555)2.59033061
45Mildly elevated creatine phosphokinase (HP:0008180)2.58853959
46Spinal rigidity (HP:0003306)2.56907423
47Hypoplastic ischia (HP:0003175)2.56128542
48Bell-shaped thorax (HP:0001591)2.54989886
49Exercise-induced myalgia (HP:0003738)2.51782377
50Muscle hypertrophy of the lower extremities (HP:0008968)2.49931605
51Abnormality of the calf musculature (HP:0001430)2.49687125
52Abnormality of the calcaneus (HP:0008364)2.49659211
53Ankle contracture (HP:0006466)2.48191932
54Myotonia (HP:0002486)2.42946727
55Abnormality of the ischium (HP:0003174)2.42900406
56Slender build (HP:0001533)2.41418135
57Hip contracture (HP:0003273)2.38578252
58Mesomelia (HP:0003027)2.37082823
59Abnormality of the musculature of the pelvis (HP:0001469)2.36769363
60Abnormality of the hip-girdle musculature (HP:0001445)2.36769363
61Abnormality of skeletal muscle fiber size (HP:0012084)2.36683872
62Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.35198096
63Calf muscle hypertrophy (HP:0008981)2.33958599
64Long clavicles (HP:0000890)2.32661940
65Fetal akinesia sequence (HP:0001989)2.27123719
66Knee flexion contracture (HP:0006380)2.26936604
67Increased density of long bones (HP:0006392)2.26465499
68Bulbar palsy (HP:0001283)2.24995171
69EMG: myopathic abnormalities (HP:0003458)2.24994200
70Shoulder girdle muscle weakness (HP:0003547)2.24004015
71Tarsal synostosis (HP:0008368)2.23123677
72Atrophic scars (HP:0001075)2.22421801
73Increased variability in muscle fiber diameter (HP:0003557)2.20866249
74Wrist flexion contracture (HP:0001239)2.19564923
75Abnormality of the shoulder girdle musculature (HP:0001435)2.16971568
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.15067270
77Osteolytic defects of the hand bones (HP:0009699)2.15067270
78Abnormality of the 4th metacarpal (HP:0010012)2.14987844
79Areflexia of lower limbs (HP:0002522)2.13124266
80Generalized muscle weakness (HP:0003324)2.11856605
81Metatarsus adductus (HP:0001840)2.09036657
82Spinal cord lesions (HP:0100561)2.08446377
83Syringomyelia (HP:0003396)2.08446377
84Limited hip movement (HP:0008800)2.08285471
85Reduced subcutaneous adipose tissue (HP:0003758)2.08179890
86Sudden death (HP:0001699)2.07811744
87Soft skin (HP:0000977)2.07221791
88Abnormality of placental membranes (HP:0011409)2.06723992
89Amniotic constriction ring (HP:0009775)2.06723992
90Lipoatrophy (HP:0100578)2.03789478
91Frequent falls (HP:0002359)2.03301176
92Down-sloping shoulders (HP:0200021)2.02841620
93Weak cry (HP:0001612)2.01526054
94Generalized amyotrophy (HP:0003700)2.01475669
95Short palpebral fissure (HP:0012745)2.00559899
96Limb-girdle muscle weakness (HP:0003325)2.00407433
97Fragile skin (HP:0001030)1.97982334
98Synostosis involving bones of the feet (HP:0009140)1.96737210
99Synostosis involving bones of the lower limbs (HP:0009138)1.96737210
100Mixed hearing impairment (HP:0000410)1.95443706
101Bundle branch block (HP:0011710)1.95222767
102Thin ribs (HP:0000883)1.93881217
103Wormian bones (HP:0002645)1.93068589
104Aortic dissection (HP:0002647)1.93061151
105Asymmetry of the thorax (HP:0001555)1.92253673
106Breech presentation (HP:0001623)1.91300910
107Type 2 muscle fiber atrophy (HP:0003554)1.91038927
108Abnormal atrioventricular conduction (HP:0005150)1.90894323
109Muscle fiber atrophy (HP:0100295)1.90487427
110Aplasia of the musculature (HP:0100854)1.89558764
111Elbow flexion contracture (HP:0002987)1.89176536
112Progressive muscle weakness (HP:0003323)1.88228900
113Chin dimple (HP:0010751)1.87339381
114Distal lower limb amyotrophy (HP:0008944)1.86635236
115Deviation of the hallux (HP:0010051)1.86284525
116Dilated cardiomyopathy (HP:0001644)1.85761626
117EMG: neuropathic changes (HP:0003445)1.83627564
118Dilatation of the ascending aorta (HP:0005111)1.83043519
119Ulnar deviation of finger (HP:0009465)1.82101711
120Camptodactyly of toe (HP:0001836)1.81917460
121Respiratory insufficiency due to muscle weakness (HP:0002747)1.81540226
122Spondylolisthesis (HP:0003302)1.80479005
123Hallux valgus (HP:0001822)1.79965788
124Distal lower limb muscle weakness (HP:0009053)1.79780388
125Abnormality of dentin (HP:0010299)1.79372540
126Cervical subluxation (HP:0003308)1.77946771
127Natal tooth (HP:0000695)1.76402765
128Atrioventricular block (HP:0001678)1.76363956
129Aortic aneurysm (HP:0004942)1.76127595
130Broad metatarsal (HP:0001783)1.76010292
131Heart block (HP:0012722)1.75748406
132Gowers sign (HP:0003391)1.74916407
133Bladder diverticulum (HP:0000015)1.73546143
134Proximal amyotrophy (HP:0007126)1.73543078
135Hyperkalemia (HP:0002153)1.73042679
136Mitral valve prolapse (HP:0001634)1.72961011
137Muscular dystrophy (HP:0003560)1.71173227
138Abnormality of the umbilical cord (HP:0010881)1.71136515
139Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.66572587
140Abnormal delivery (HP:0001787)1.65732623
141Nonprogressive disorder (HP:0003680)1.65162910

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.55535736
2TTN4.43131664
3EPHA33.97112216
4TRIB33.73707658
5LATS13.45556314
6OBSCN2.83299781
7ERBB32.55947673
8TRPM72.47886412
9PDGFRA2.05147162
10CDK61.97966577
11SIK11.83114360
12EPHA21.79338881
13MOS1.78872344
14NEK91.78690376
15PIK3CG1.76344940
16RIPK11.75381883
17PKN21.74038785
18ZAK1.73837982
19STK31.68247461
20LATS21.57754233
21VRK21.54063683
22LIMK11.53445195
23EPHB21.49627937
24CDK121.44859435
25EPHB11.39760855
26RPS6KA41.35640480
27DYRK1B1.34787583
28PHKG11.33186028
29PHKG21.33186028
30MAP2K31.29178720
31PTK61.26805649
32TESK11.23086240
33DMPK1.22789474
34RPS6KB21.19045858
35ICK1.16730934
36NME21.14234415
37MAP3K101.14091999
38FER1.11579824
39SMG11.07043507
40MYLK1.06694922
41NEK11.04506242
42MAP2K11.04243212
43FGFR31.00879577
44EEF2K0.98733127
45LRRK20.97029603
46MAPK120.96515967
47BMX0.93411676
48FGFR10.90864087
49CCNB10.90674300
50CDC70.88280978
51PAK40.86159124
52NEK20.83805207
53MAPKAPK30.83688892
54MTOR0.82888009
55MAPK150.82544813
56MUSK0.81413245
57MAP3K120.81155860
58MAP3K20.80362374
59TGFBR10.78949182
60NME10.76553036
61PTK20.76117710
62PAK20.74658904
63MAP3K30.74047409
64MST1R0.73252567
65BUB10.72303082
66FGFR40.72120495
67ILK0.71933052
68HIPK20.71871423
69IRAK30.71469526
70STK380.69249380
71CDK80.68916492
72ERBB40.68189426
73FRK0.67365122
74PIM20.65923651
75NUAK10.65896180
76NTRK10.65485929
77CAMK2G0.64096416
78TLK10.63033118
79TAOK20.62289853
80MAP3K70.61145367
81PRKAA20.59913581
82PDGFRB0.59902800
83PDK20.59723143
84MELK0.57814085
85PIK3CA0.56041126
86SCYL20.55671521
87AKT20.53514111
88MAP3K80.52362308
89MKNK10.51966234
90MAPK70.51850169
91ROCK10.50821251
92PBK0.50595395
93ERBB20.49693082
94YES10.49228695
95ABL20.48975942
96CHUK0.48428299
97BCKDK0.48282187
98AURKB0.47562589
99STK160.47124571
100PAK30.46950214
101PNCK0.46557482
102PAK60.45911451
103MAPK110.44537091
104RET0.43879621
105WNK10.42916363
106CDK90.42662073
107ARAF0.42505436
108PLK30.40715634
109PRKD20.39892140
110EIF2AK10.39604543
111PRKAA10.39514668
112CDK70.37784459
113JAK10.37681926
114MAPKAPK20.37472133
115KSR20.37302340
116ROCK20.36449101
117STK240.35689379
118BCR0.35672027
119MET0.35273486
120FGFR20.35150190
121TGFBR20.34679101
122DYRK30.34587573
123TTK0.34021870
124RPS6KA20.33887774
125MKNK20.33558684
126TAF10.32324592
127STK100.32314653
128STK38L0.32007492
129FLT30.31760669
130ALK0.31272771
131PTK2B0.31265353
132BMPR1B0.31090707
133NLK0.31069251
134BRSK10.30123812
135RPS6KC10.30018512
136RPS6KL10.30018512
137AURKA0.29772280
138PAK10.29675909
139AKT30.28727565
140MAP2K20.28229271
141PRKG10.27750533
142PIM10.27461186
143CDK140.27327507
144RPS6KA50.27098898
145CAMK2D0.26998394
146PRPF4B0.25574137
147MAP2K40.24070034

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.19907268
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.11969255
3Cardiac muscle contraction_Homo sapiens_hsa042602.31675734
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.30621781
5Adherens junction_Homo sapiens_hsa045202.19273564
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.10162525
7Focal adhesion_Homo sapiens_hsa045102.00927796
8ECM-receptor interaction_Homo sapiens_hsa045121.98826687
9Hippo signaling pathway_Homo sapiens_hsa043901.97947316
10Proteoglycans in cancer_Homo sapiens_hsa052051.97404058
11Pyruvate metabolism_Homo sapiens_hsa006201.95920514
12Chronic myeloid leukemia_Homo sapiens_hsa052201.95584845
13Pentose phosphate pathway_Homo sapiens_hsa000301.92963345
14TGF-beta signaling pathway_Homo sapiens_hsa043501.92380889
15Basal cell carcinoma_Homo sapiens_hsa052171.87057421
16MicroRNAs in cancer_Homo sapiens_hsa052061.76936430
17Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.75316366
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.75278924
19Dilated cardiomyopathy_Homo sapiens_hsa054141.73873671
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73081097
21Viral myocarditis_Homo sapiens_hsa054161.70511883
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.70044134
23Carbon metabolism_Homo sapiens_hsa012001.68235382
24Phenylalanine metabolism_Homo sapiens_hsa003601.64564570
25Sulfur relay system_Homo sapiens_hsa041221.63534990
26Small cell lung cancer_Homo sapiens_hsa052221.58640294
27Prostate cancer_Homo sapiens_hsa052151.49614597
28p53 signaling pathway_Homo sapiens_hsa041151.47260484
29Melanoma_Homo sapiens_hsa052181.46605589
30Arginine and proline metabolism_Homo sapiens_hsa003301.46298721
31Cell cycle_Homo sapiens_hsa041101.45312552
32Biosynthesis of amino acids_Homo sapiens_hsa012301.42698998
33Tight junction_Homo sapiens_hsa045301.42565678
34FoxO signaling pathway_Homo sapiens_hsa040681.40216590
35Bladder cancer_Homo sapiens_hsa052191.39904448
36Amoebiasis_Homo sapiens_hsa051461.38847962
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36141840
38Fatty acid elongation_Homo sapiens_hsa000621.33012920
39Leishmaniasis_Homo sapiens_hsa051401.32992832
40Sulfur metabolism_Homo sapiens_hsa009201.29681893
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29013286
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27730912
43HTLV-I infection_Homo sapiens_hsa051661.27361270
44TNF signaling pathway_Homo sapiens_hsa046681.25765149
45Pancreatic cancer_Homo sapiens_hsa052121.25665350
46Toxoplasmosis_Homo sapiens_hsa051451.24718782
47Prolactin signaling pathway_Homo sapiens_hsa049171.24707823
48Fructose and mannose metabolism_Homo sapiens_hsa000511.23572967
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21854862
50Hepatitis B_Homo sapiens_hsa051611.20633235
51Huntingtons disease_Homo sapiens_hsa050161.19995130
52Insulin signaling pathway_Homo sapiens_hsa049101.17068737
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14867732
54Hedgehog signaling pathway_Homo sapiens_hsa043401.14648277
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13747110
56mTOR signaling pathway_Homo sapiens_hsa041501.11836155
57Viral carcinogenesis_Homo sapiens_hsa052031.11764092
58* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10331345
59Fatty acid degradation_Homo sapiens_hsa000711.08365502
60Central carbon metabolism in cancer_Homo sapiens_hsa052301.08026355
61Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06846083
62Colorectal cancer_Homo sapiens_hsa052101.06605934
63Propanoate metabolism_Homo sapiens_hsa006401.06266026
64Leukocyte transendothelial migration_Homo sapiens_hsa046701.05899201
65Insulin resistance_Homo sapiens_hsa049311.05540041
66Notch signaling pathway_Homo sapiens_hsa043301.05107760
67Pathways in cancer_Homo sapiens_hsa052001.03522298
68Endometrial cancer_Homo sapiens_hsa052131.03434662
69VEGF signaling pathway_Homo sapiens_hsa043701.03240650
70cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01726894
71Wnt signaling pathway_Homo sapiens_hsa043101.01622471
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.99888166
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99761890
74Fatty acid metabolism_Homo sapiens_hsa012120.99647246
75GnRH signaling pathway_Homo sapiens_hsa049120.97991892
76Glioma_Homo sapiens_hsa052140.96561050
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95509250
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93974149
79Apoptosis_Homo sapiens_hsa042100.91876901
80Legionellosis_Homo sapiens_hsa051340.91508692
81Alzheimers disease_Homo sapiens_hsa050100.90692704
82Thyroid cancer_Homo sapiens_hsa052160.90529914
83Calcium signaling pathway_Homo sapiens_hsa040200.90462910
84HIF-1 signaling pathway_Homo sapiens_hsa040660.90316796
85Salmonella infection_Homo sapiens_hsa051320.90138576
86Tyrosine metabolism_Homo sapiens_hsa003500.89484855
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.87748425
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87259465
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85768718
90Dorso-ventral axis formation_Homo sapiens_hsa043200.84070807
91Malaria_Homo sapiens_hsa051440.83892469
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83135236
93Protein digestion and absorption_Homo sapiens_hsa049740.82810522
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82781817
95Systemic lupus erythematosus_Homo sapiens_hsa053220.82206168
96AMPK signaling pathway_Homo sapiens_hsa041520.82108016
97Parkinsons disease_Homo sapiens_hsa050120.80048301
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79616064
99Renal cell carcinoma_Homo sapiens_hsa052110.78493089
100Oxytocin signaling pathway_Homo sapiens_hsa049210.78448140
101Shigellosis_Homo sapiens_hsa051310.77070698
102Nucleotide excision repair_Homo sapiens_hsa034200.76598336
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74013115
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73586136
105Autoimmune thyroid disease_Homo sapiens_hsa053200.73468026
106MAPK signaling pathway_Homo sapiens_hsa040100.73173442
107Arginine biosynthesis_Homo sapiens_hsa002200.72768074
108Lysine degradation_Homo sapiens_hsa003100.72730481
109Galactose metabolism_Homo sapiens_hsa000520.72558429
110Non-small cell lung cancer_Homo sapiens_hsa052230.72100819
111beta-Alanine metabolism_Homo sapiens_hsa004100.71929235
112Axon guidance_Homo sapiens_hsa043600.71863029
113Starch and sucrose metabolism_Homo sapiens_hsa005000.69888541
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68513855
115Acute myeloid leukemia_Homo sapiens_hsa052210.67999418
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67797017
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67350516
118Osteoclast differentiation_Homo sapiens_hsa043800.66797860
119Melanogenesis_Homo sapiens_hsa049160.64388512
120Platelet activation_Homo sapiens_hsa046110.63263949
121Circadian rhythm_Homo sapiens_hsa047100.62486503
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.61833893
123Epstein-Barr virus infection_Homo sapiens_hsa051690.61583851
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61352238
125Influenza A_Homo sapiens_hsa051640.61125551
126Ovarian steroidogenesis_Homo sapiens_hsa049130.61055281
127Type II diabetes mellitus_Homo sapiens_hsa049300.60194858
128Glutathione metabolism_Homo sapiens_hsa004800.59422804
129Herpes simplex infection_Homo sapiens_hsa051680.58199478
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58037396
131Purine metabolism_Homo sapiens_hsa002300.58017311
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57874573
133Folate biosynthesis_Homo sapiens_hsa007900.57811888
134PPAR signaling pathway_Homo sapiens_hsa033200.56929853
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56326009
136Tuberculosis_Homo sapiens_hsa051520.55770391
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55637680
138Rap1 signaling pathway_Homo sapiens_hsa040150.55456237
139Estrogen signaling pathway_Homo sapiens_hsa049150.54596595
140NF-kappa B signaling pathway_Homo sapiens_hsa040640.54411172
141Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52757008
142Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51849304
143Glucagon signaling pathway_Homo sapiens_hsa049220.51130309
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50337621
145Pyrimidine metabolism_Homo sapiens_hsa002400.50193511
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.47567530
147Fatty acid biosynthesis_Homo sapiens_hsa000610.46138398
148Oxidative phosphorylation_Homo sapiens_hsa001900.44929487
149One carbon pool by folate_Homo sapiens_hsa006700.44568827
150RNA polymerase_Homo sapiens_hsa030200.43605685
151Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42941437
152Proteasome_Homo sapiens_hsa030500.42909246
153Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42166129

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