SIX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of granulocyte differentiation (GO:0030853)6.67538545
2negative regulation of macrophage differentiation (GO:0045650)6.30026261
3axonemal dynein complex assembly (GO:0070286)5.82290164
4motile cilium assembly (GO:0044458)5.06565464
5metanephric mesenchyme development (GO:0072075)5.04875644
6kidney mesenchyme development (GO:0072074)4.91317213
7mesonephros development (GO:0001823)4.83531656
8muscle cell fate commitment (GO:0042693)4.78131060
9G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.65749554
10cranial nerve morphogenesis (GO:0021602)4.43017970
11* mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.36223801
12layer formation in cerebral cortex (GO:0021819)4.35599496
13regulation of monocyte differentiation (GO:0045655)4.32900777
14lateral sprouting from an epithelium (GO:0060601)4.24214994
15left/right pattern formation (GO:0060972)4.15908457
16regulation of non-canonical Wnt signaling pathway (GO:2000050)4.03333929
17forelimb morphogenesis (GO:0035136)3.96058679
18embryonic forelimb morphogenesis (GO:0035115)3.95515642
19embryonic skeletal joint morphogenesis (GO:0060272)3.94010406
20cilium or flagellum-dependent cell motility (GO:0001539)3.93568048
21proximal/distal pattern formation (GO:0009954)3.89923386
22outer ear morphogenesis (GO:0042473)3.85444708
23negative regulation of axon extension involved in axon guidance (GO:0048843)3.83711786
24* mesenchymal cell differentiation involved in kidney development (GO:0072161)3.78872012
25* mesenchymal cell differentiation involved in renal system development (GO:2001012)3.78872012
26limb bud formation (GO:0060174)3.78071281
27postsynaptic membrane organization (GO:0001941)3.76086831
28sympathetic nervous system development (GO:0048485)3.75357174
29pyrimidine dimer repair (GO:0006290)3.72734118
30cranial nerve structural organization (GO:0021604)3.71274261
31* middle ear morphogenesis (GO:0042474)3.70473498
32neural crest cell development (GO:0014032)3.68634606
33head development (GO:0060322)3.68494903
34metanephros development (GO:0001656)3.67217458
35positive regulation of protein targeting to membrane (GO:0090314)3.65441090
36cell differentiation involved in metanephros development (GO:0072202)3.63577257
37nonmotile primary cilium assembly (GO:0035058)3.59828247
38cell migration in hindbrain (GO:0021535)3.59378819
39regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.59263519
40establishment of tissue polarity (GO:0007164)3.54009848
41establishment of planar polarity (GO:0001736)3.54009848
42negative regulation of axon guidance (GO:1902668)3.52349103
43facial nerve structural organization (GO:0021612)3.51559764
44* mesenchymal to epithelial transition (GO:0060231)3.50222416
45mesenchymal cell development (GO:0014031)3.49284932
46muscle filament sliding (GO:0030049)3.46785338
47actin-myosin filament sliding (GO:0033275)3.46785338
48cerebral cortex radially oriented cell migration (GO:0021799)3.41277817
49cilium movement (GO:0003341)3.40540687
50ionotropic glutamate receptor signaling pathway (GO:0035235)3.40513217
51diaphragm development (GO:0060539)3.39315266
52cell-cell signaling involved in cell fate commitment (GO:0045168)3.34037031
53regulation of organ formation (GO:0003156)3.33937481
54planar cell polarity pathway involved in neural tube closure (GO:0090179)3.33914171
55presynaptic membrane assembly (GO:0097105)3.33725972
56developmental induction (GO:0031128)3.32166295
57cochlea morphogenesis (GO:0090103)3.30450441
58embryonic appendage morphogenesis (GO:0035113)3.27021833
59embryonic limb morphogenesis (GO:0030326)3.27021833
60negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.26433029
61organ induction (GO:0001759)3.26029640
62ganglion development (GO:0061548)3.25792959
63skeletal muscle organ development (GO:0060538)3.25605700
64positive regulation of mesonephros development (GO:0061213)3.25427614
65regulation of cardioblast proliferation (GO:0003264)3.23490632
66regulation of secondary heart field cardioblast proliferation (GO:0003266)3.23490632
67pericardium development (GO:0060039)3.21105695
68presynaptic membrane organization (GO:0097090)3.19539777
69regulation of skeletal muscle contraction (GO:0014819)3.18469304
70* embryonic skeletal system morphogenesis (GO:0048704)3.14476695
71embryonic digit morphogenesis (GO:0042733)3.14137482
72regulation of glomerulus development (GO:0090192)3.13681591
73dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.13077738
74actin-mediated cell contraction (GO:0070252)3.12903975
75apical protein localization (GO:0045176)3.12579906
76positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.12435157
77G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.12256089
78myoblast fusion (GO:0007520)3.11172933
79regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.10158410
80regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.09271748
81extracellular negative regulation of signal transduction (GO:1900116)3.08552112
82extracellular regulation of signal transduction (GO:1900115)3.08552112
83adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.08192738
84skeletal muscle contraction (GO:0003009)3.07528901
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06313187
86regulation of mesenchymal cell apoptotic process (GO:2001053)3.03977559
87protein heterotrimerization (GO:0070208)3.01849696
88stem cell development (GO:0048864)3.01170530
89chondrocyte proliferation (GO:0035988)3.01101069
90histone H2B ubiquitination (GO:0033523)2.99432412
91appendage morphogenesis (GO:0035107)2.99027556
92limb morphogenesis (GO:0035108)2.99027556
93* mesenchymal cell differentiation (GO:0048762)2.97589359
94lymph vessel development (GO:0001945)2.95962232
95mesenchyme morphogenesis (GO:0072132)2.95738327
96axonal fasciculation (GO:0007413)2.95117436
97negative regulation of keratinocyte proliferation (GO:0010839)2.94726391
98hindlimb morphogenesis (GO:0035137)2.94637285
99* regulation of mesonephros development (GO:0061217)2.93861191
100anatomical structure arrangement (GO:0048532)2.93636420
101* embryonic cranial skeleton morphogenesis (GO:0048701)2.93596769
102skeletal muscle fiber development (GO:0048741)2.92815734
103plasma membrane repair (GO:0001778)2.92732065
104epithelial cilium movement (GO:0003351)2.91969502
105protein polyglutamylation (GO:0018095)2.89667203
106axon extension (GO:0048675)2.89482156
107negative regulation of potassium ion transmembrane transport (GO:1901380)2.87932479
108cell proliferation involved in metanephros development (GO:0072203)2.87526937
109enteric nervous system development (GO:0048484)2.87178630
110camera-type eye morphogenesis (GO:0048593)2.86789530
111negative regulation of axon extension (GO:0030517)2.86616872
112branching involved in ureteric bud morphogenesis (GO:0001658)2.85778691
113cell proliferation involved in kidney development (GO:0072111)2.85669050
114positive regulation of embryonic development (GO:0040019)2.85455275
115epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.85144478
116lateral ventricle development (GO:0021670)2.85091850
117regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83242558
118* cell differentiation involved in kidney development (GO:0061005)2.82335474
119collagen fibril organization (GO:0030199)2.79956236
120tooth mineralization (GO:0034505)2.79752006
121axon ensheathment in central nervous system (GO:0032291)2.79158232
122central nervous system myelination (GO:0022010)2.79158232
123positive regulation of gastrulation (GO:2000543)2.78900681
124righting reflex (GO:0060013)2.78806804
125* regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.78215310
126eyelid development in camera-type eye (GO:0061029)2.77101818
127skin morphogenesis (GO:0043589)2.76929877
128negative chemotaxis (GO:0050919)2.75943575
129neuron recognition (GO:0008038)2.75936293
130mesenchymal cell proliferation (GO:0010463)2.75829417
131negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.75524534
132regulation of protein targeting to membrane (GO:0090313)2.75100565
133bone trabecula formation (GO:0060346)2.75041656
134neuron cell-cell adhesion (GO:0007158)2.74927286
135import into cell (GO:0098657)2.72977496
136regulation of mesoderm development (GO:2000380)2.72647822
137face development (GO:0060324)2.69996202
138cell proliferation in forebrain (GO:0021846)2.69777565
139nephron tubule formation (GO:0072079)2.69762351
140urogenital system development (GO:0001655)2.69647809
141Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.69629254
142myotube cell development (GO:0014904)2.68867542
143sequestering of extracellular ligand from receptor (GO:0035581)2.68812570
144embryonic hindlimb morphogenesis (GO:0035116)2.68724407
145syncytium formation by plasma membrane fusion (GO:0000768)2.67536905
146regulation of mesenchymal cell proliferation (GO:0010464)2.67060600
147pharyngeal system development (GO:0060037)2.66619203
148regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.65971627
149regulation of male gonad development (GO:2000018)2.65924822
150startle response (GO:0001964)2.64885494
151ureteric bud development (GO:0001657)2.64395704
152negative regulation of myoblast differentiation (GO:0045662)2.63948731
153axon extension involved in axon guidance (GO:0048846)2.63546909
154neuron projection extension involved in neuron projection guidance (GO:1902284)2.63546909
155aorta morphogenesis (GO:0035909)2.62949139
156skeletal muscle tissue development (GO:0007519)2.61139927
157regulation of heart morphogenesis (GO:2000826)2.60270906
158regulation of DNA endoreduplication (GO:0032875)2.59853098
159neuron fate specification (GO:0048665)2.57210588
160asymmetric protein localization (GO:0008105)2.54814056
161establishment of nucleus localization (GO:0040023)2.52951953
162heterochromatin organization (GO:0070828)2.51540031
163fibroblast migration (GO:0010761)2.48748995
164establishment of apical/basal cell polarity (GO:0035089)2.48102910
165myotube differentiation (GO:0014902)2.46239743
166coronary vasculature morphogenesis (GO:0060977)2.46146392
167establishment or maintenance of bipolar cell polarity (GO:0061245)2.45369500
168establishment or maintenance of apical/basal cell polarity (GO:0035088)2.45369500
169actin filament-based movement (GO:0030048)2.42507706
170positive regulation of myotube differentiation (GO:0010831)2.41655109
171protein retention in ER lumen (GO:0006621)2.41623734
172GDP-mannose metabolic process (GO:0019673)2.41458439
173response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.40903688
174neuron projection extension (GO:1990138)2.39024210
175regulation of receptor recycling (GO:0001919)2.37456014
176response to inactivity (GO:0014854)2.36005601
177striated muscle atrophy (GO:0014891)2.33384023
178cilium assembly (GO:0042384)2.32876768
179cerebellum development (GO:0021549)2.29457726
180cilium organization (GO:0044782)2.29170354
181positive regulation of protein depolymerization (GO:1901881)2.28722048
182syncytium formation (GO:0006949)2.28478360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.42162847
2EZH2_22144423_ChIP-Seq_EOC_Human4.12062594
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.84863513
4GBX2_23144817_ChIP-Seq_PC3_Human3.53980967
5* EED_16625203_ChIP-ChIP_MESCs_Mouse3.18062180
6* EZH2_27304074_Chip-Seq_ESCs_Mouse3.00947774
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95647923
8* CBX2_27304074_Chip-Seq_ESCs_Mouse2.88889217
9* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.79789039
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75521398
11* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.71156112
12* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.67828248
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64858709
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64858709
15* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61295678
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57375505
17* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.57228350
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53965878
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51789188
20* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43489917
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.36128838
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.21347302
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15076372
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.06651269
25TAF15_26573619_Chip-Seq_HEK293_Human2.05508535
26* RNF2_27304074_Chip-Seq_NSC_Mouse2.05346251
27FUS_26573619_Chip-Seq_HEK293_Human1.99858370
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98530355
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.95681941
30* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93095735
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.92515607
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86938813
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86299791
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85896744
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80486403
36* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79554726
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.76311369
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76248567
39* P300_19829295_ChIP-Seq_ESCs_Human1.75625261
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72371859
41AR_21572438_ChIP-Seq_LNCaP_Human1.72015654
42VDR_22108803_ChIP-Seq_LS180_Human1.71984484
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.71495679
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70361552
45EWS_26573619_Chip-Seq_HEK293_Human1.64833760
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60696171
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58919019
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.56853834
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.56165492
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55587198
51KDM2B_26808549_Chip-Seq_K562_Human1.53310032
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52923425
53* TP53_20018659_ChIP-ChIP_R1E_Mouse1.52891871
54* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48839112
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47374014
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46140631
57TP53_18474530_ChIP-ChIP_U2OS_Human1.45327184
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44425381
59DROSHA_22980978_ChIP-Seq_HELA_Human1.44122892
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43763129
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42697565
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42677055
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41225269
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40563604
65* RING1B_27294783_Chip-Seq_NPCs_Mouse1.39735607
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39732401
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39025843
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35090262
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34761747
70* RACK7_27058665_Chip-Seq_MCF-7_Human1.34485284
71ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33609131
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33559306
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33559306
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.33510309
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32838164
76CREB1_26743006_Chip-Seq_LNCaP_Human1.32625993
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32168325
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.32142210
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.32128403
80* RING1B_27294783_Chip-Seq_ESCs_Mouse1.31052397
81SMAD4_21799915_ChIP-Seq_A2780_Human1.31051974
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30427660
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29423871
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.29254596
85* TP63_19390658_ChIP-ChIP_HaCaT_Human1.28864053
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27818014
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26705007
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26407602
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26362529
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25882201
91ER_23166858_ChIP-Seq_MCF-7_Human1.25544336
92CTCF_27219007_Chip-Seq_Bcells_Human1.25372276
93LXR_22292898_ChIP-Seq_THP-1_Human1.24814613
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.24354675
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23190867
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23156778
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21961193
98P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21954232
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20942439
100IGF1R_20145208_ChIP-Seq_DFB_Human1.19459844
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18787014
102CLOCK_20551151_ChIP-Seq_293T_Human1.18716990
103TBX20_22080862_ChIP-Seq_HEART_Mouse1.18103647
104TBX20_22328084_ChIP-Seq_HEART_Mouse1.18103647
105RARB_27405468_Chip-Seq_BRAIN_Mouse1.17704292
106TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16897237
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.16726125
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.13832357
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13094856
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11899980
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11454606
112RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11185340
113SMAD_19615063_ChIP-ChIP_OVARY_Human1.10815813
114AR_25329375_ChIP-Seq_VCAP_Human1.10800951
115P53_22387025_ChIP-Seq_ESCs_Mouse1.10399127
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09702008
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09348176
118DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08715010
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08549024
120CMYC_18555785_Chip-Seq_ESCs_Mouse1.08468432
121* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08210966
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.07923024
123TAL1_26923725_Chip-Seq_HPCs_Mouse1.07848737
124* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07212821
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06951382
126TET1_21490601_ChIP-Seq_MESCs_Mouse1.06306653
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06042158
128ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04895610
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04349319
130* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04084159
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03988772
132P300_18555785_Chip-Seq_ESCs_Mouse1.02466842
133TET1_21451524_ChIP-Seq_MESCs_Mouse1.02446459
134ERG_21242973_ChIP-ChIP_JURKAT_Human1.02410791
135AHR_22903824_ChIP-Seq_MCF-7_Human1.02258453
136NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01352260
137ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01159019
138GATA1_26923725_Chip-Seq_HPCs_Mouse1.01012616
139RUNX2_22187159_ChIP-Seq_PCA_Human1.00726556
140STAT3_23295773_ChIP-Seq_U87_Human1.00598912
141ISL1_27105846_Chip-Seq_CPCs_Mouse1.00419078
142STAT3_18555785_Chip-Seq_ESCs_Mouse1.00301794
143REST_21632747_ChIP-Seq_MESCs_Mouse1.00067336
144EZH2_27294783_Chip-Seq_NPCs_Mouse0.99868718
145ELK3_25401928_ChIP-Seq_HUVEC_Human0.99745160
146SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98501206
147* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98273414
148AR_19668381_ChIP-Seq_PC3_Human0.96900146
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94627967
150FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94311101
151SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93849136
152KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93142155
153CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92628912
154TP53_23651856_ChIP-Seq_MEFs_Mouse0.92215804
155SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90972367
156MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89533717
157KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87929132
158TP53_22127205_ChIP-Seq_IMR90_Human0.87017030
159KDM2B_26808549_Chip-Seq_JURKAT_Human0.86717813
160KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86591200
161ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85974424
162TP63_17297297_ChIP-ChIP_HaCaT_Human0.85540981
163MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.83674045
164KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.82679119
165SMC4_20622854_ChIP-Seq_HELA_Human0.82547791
166MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.82156783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004270_analgesia3.62896447
2MP0000566_synostosis3.54851351
3MP0008438_abnormal_cutaneous_collagen3.52873801
4MP0010030_abnormal_orbit_morphology3.11814824
5MP0009250_abnormal_appendicular_skeleto3.09066589
6MP0002249_abnormal_larynx_morphology3.03707779
7MP0009780_abnormal_chondrocyte_physiolo2.99690339
8MP0000049_abnormal_middle_ear2.95672810
9MP0003385_abnormal_body_wall2.71634545
10MP0003938_abnormal_ear_development2.56098949
11* MP0003942_abnormal_urinary_system2.49359997
12MP0000751_myopathy2.43231791
13MP0002160_abnormal_reproductive_system2.34773707
14MP0001346_abnormal_lacrimal_gland2.34327989
15MP0003937_abnormal_limbs/digits/tail_de2.34241502
16MP0002938_white_spotting2.30669280
17MP0000733_abnormal_muscle_development2.29871989
18MP0005257_abnormal_intraocular_pressure2.28840836
19MP0008789_abnormal_olfactory_epithelium2.27888171
20MP0003122_maternal_imprinting2.27226296
21MP0005503_abnormal_tendon_morphology2.26976106
22MP0000534_abnormal_ureter_morphology2.23455900
23MP0003705_abnormal_hypodermis_morpholog2.19230258
24MP0003950_abnormal_plasma_membrane2.19062497
25MP0006292_abnormal_olfactory_placode2.18325661
26MP0003283_abnormal_digestive_organ2.17911052
27MP0000678_abnormal_parathyroid_gland2.13854855
28MP0000013_abnormal_adipose_tissue2.11283219
29MP0002877_abnormal_melanocyte_morpholog2.08717097
30MP0002233_abnormal_nose_morphology2.07318580
31MP0003136_yellow_coat_color2.06577574
32MP0003755_abnormal_palate_morphology2.03830761
33MP0000762_abnormal_tongue_morphology2.02224861
34MP0003941_abnormal_skin_development1.99058705
35MP0000749_muscle_degeneration1.97712259
36MP0002102_abnormal_ear_morphology1.94786437
37MP0001440_abnormal_grooming_behavior1.92617565
38MP0001542_abnormal_bone_strength1.90300151
39MP0000750_abnormal_muscle_regeneration1.86781380
40MP0000759_abnormal_skeletal_muscle1.79408253
41MP0004133_heterotaxia1.73024497
42MP0005171_absent_coat_pigmentation1.71860049
43MP0001188_hyperpigmentation1.67628068
44MP0000026_abnormal_inner_ear1.65690919
45MP0000003_abnormal_adipose_tissue1.65472796
46MP0000747_muscle_weakness1.62860130
47MP0004233_abnormal_muscle_weight1.59879820
48MP0000778_abnormal_nervous_system1.58727483
49MP0005394_taste/olfaction_phenotype1.58516945
50MP0005499_abnormal_olfactory_system1.58516945
51MP0003121_genomic_imprinting1.56336578
52MP0000537_abnormal_urethra_morphology1.54080899
53MP0005409_darkened_coat_color1.53731925
54MP0004858_abnormal_nervous_system1.53168687
55MP0004087_abnormal_muscle_fiber1.52858410
56MP0002116_abnormal_craniofacial_bone1.49611662
57MP0002277_abnormal_respiratory_mucosa1.49422436
58MP0009053_abnormal_anal_canal1.49359074
59MP0003880_abnormal_central_pattern1.49241438
60MP0002932_abnormal_joint_morphology1.47977462
61MP0005367_renal/urinary_system_phenotyp1.44194211
62MP0000516_abnormal_urinary_system1.44194211
63MP0004134_abnormal_chest_morphology1.43794764
64MP0002734_abnormal_mechanical_nocicepti1.41390071
65MP0002109_abnormal_limb_morphology1.40995591
66MP0005248_abnormal_Harderian_gland1.40769472
67MP0000631_abnormal_neuroendocrine_gland1.40099363
68MP0005623_abnormal_meninges_morphology1.39752107
69MP0003935_abnormal_craniofacial_develop1.37025701
70MP0002282_abnormal_trachea_morphology1.37017991
71MP0002638_abnormal_pupillary_reflex1.36705802
72MP0005275_abnormal_skin_tensile1.36611582
73MP0002177_abnormal_outer_ear1.35830078
74MP0004742_abnormal_vestibular_system1.30716768
75MP0001486_abnormal_startle_reflex1.29561600
76MP0005508_abnormal_skeleton_morphology1.28048581
77MP0002896_abnormal_bone_mineralization1.24956212
78MP0005369_muscle_phenotype1.24502285
79MP0002184_abnormal_innervation1.24153148
80MP0002697_abnormal_eye_size1.21242717
81MP0005423_abnormal_somatic_nervous1.19718071
82MP0001879_abnormal_lymphatic_vessel1.18174936
83MP0004859_abnormal_synaptic_plasticity1.17775471
84MP0001984_abnormal_olfaction1.17422509
85MP0003787_abnormal_imprinting1.17313383
86MP0003123_paternal_imprinting1.17251240
87MP0004381_abnormal_hair_follicle1.17015632
88MP0005646_abnormal_pituitary_gland1.16529887
89MP0000163_abnormal_cartilage_morphology1.16327490
90MP0002106_abnormal_muscle_physiology1.15624365
91MP0002751_abnormal_autonomic_nervous1.14771343
92MP0001340_abnormal_eyelid_morphology1.14765476
93MP0000432_abnormal_head_morphology1.14761637
94MP0003879_abnormal_hair_cell1.14695606
95MP0001286_abnormal_eye_development1.12912821
96MP0000383_abnormal_hair_follicle1.11833659
97MP0001963_abnormal_hearing_physiology1.10037674
98MP0001270_distended_abdomen1.08119210
99MP0002114_abnormal_axial_skeleton1.07908764
100MP0000428_abnormal_craniofacial_morphol1.07642172
101MP0009384_cardiac_valve_regurgitation1.06134633
102MP0001485_abnormal_pinna_reflex1.05829171
103MP0002752_abnormal_somatic_nervous1.01602835
104MP0002115_abnormal_skeleton_extremities1.00534801
105MP0000613_abnormal_salivary_gland0.99543556
106MP0002234_abnormal_pharynx_morphology0.99247095
107MP0003315_abnormal_perineum_morphology0.98774265
108MP0002909_abnormal_adrenal_gland0.97539186
109MP0004145_abnormal_muscle_electrophysio0.97445735
110MP0004130_abnormal_muscle_cell0.97015534
111MP0000681_abnormal_thyroid_gland0.96949487
112MP0001502_abnormal_circadian_rhythm0.94734572
113MP0002733_abnormal_thermal_nociception0.93932175
114MP0005645_abnormal_hypothalamus_physiol0.92974338
115MP0010368_abnormal_lymphatic_system0.92008428
116MP0005330_cardiomyopathy0.90644977
117MP0001348_abnormal_lacrimal_gland0.90207846
118MP0003861_abnormal_nervous_system0.89873429
119MP0002108_abnormal_muscle_morphology0.89532483
120MP0006276_abnormal_autonomic_nervous0.88859779
121MP0004272_abnormal_basement_membrane0.88776407
122MP0000462_abnormal_digestive_system0.88596644
123MP0002111_abnormal_tail_morphology0.88438209
124MP0001958_emphysema0.87504743
125MP0004185_abnormal_adipocyte_glucose0.87017551
126MP0002735_abnormal_chemical_nociception0.86269583
127MP0005389_reproductive_system_phenotype0.85938098
128MP0001299_abnormal_eye_distance/0.85613314
129MP0001293_anophthalmia0.83980044
130MP0002269_muscular_atrophy0.83794014
131MP0005197_abnormal_uvea_morphology0.83756888
132MP0005620_abnormal_muscle_contractility0.82924132
133MP0009379_abnormal_foot_pigmentation0.82779918
134MP0001970_abnormal_pain_threshold0.82399183
135MP0005375_adipose_tissue_phenotype0.81167656
136MP0002272_abnormal_nervous_system0.80019652
137MP0002113_abnormal_skeleton_development0.79822686
138MP0005551_abnormal_eye_electrophysiolog0.79235819
139MP0009745_abnormal_behavioral_response0.77404282
140MP0001529_abnormal_vocalization0.76592697
141MP0000372_irregular_coat_pigmentation0.76209428
142MP0002572_abnormal_emotion/affect_behav0.76055571
143MP0002971_abnormal_brown_adipose0.75865406
144MP0002736_abnormal_nociception_after0.75805795
145MP0002876_abnormal_thyroid_physiology0.75570591
146MP0002060_abnormal_skin_morphology0.75290181
147MP0003279_aneurysm0.75266231
148MP0000955_abnormal_spinal_cord0.75255758
149* MP0002081_perinatal_lethality0.74499606
150MP0005391_vision/eye_phenotype0.74438137
151MP0003119_abnormal_digestive_system0.73552520
152MP0000467_abnormal_esophagus_morphology0.73502706
153MP0002092_abnormal_eye_morphology0.72913773
154MP0002882_abnormal_neuron_morphology0.67446453
155MP0001944_abnormal_pancreas_morphology0.67319379
156MP0010630_abnormal_cardiac_muscle0.66544173

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.16846289
2Aplasia of the musculature (HP:0100854)3.96745853
3Abnormal respiratory epithelium morphology (HP:0012253)3.81518305
4Abnormal respiratory motile cilium morphology (HP:0005938)3.81518305
5Type 1 muscle fiber predominance (HP:0003803)3.81498900
6Nemaline bodies (HP:0003798)3.68682626
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.60658276
8Muscle fiber inclusion bodies (HP:0100299)3.58993213
9Abnormal respiratory motile cilium physiology (HP:0012261)3.58332925
10Calcaneovalgus deformity (HP:0001848)3.56646048
11Morphological abnormality of the middle ear (HP:0008609)3.53218017
12Deformed tarsal bones (HP:0008119)3.52122210
13Rhinitis (HP:0012384)3.49130643
14Protrusio acetabuli (HP:0003179)3.48946499
15Fetal akinesia sequence (HP:0001989)3.47146351
16Abnormality of placental membranes (HP:0011409)3.40836578
17Amniotic constriction ring (HP:0009775)3.40836578
18Abnormality of the nasolacrimal system (HP:0000614)3.35771848
19Nasolacrimal duct obstruction (HP:0000579)3.25695485
20Abnormality of the lacrimal duct (HP:0011481)3.21749421
21Lip pit (HP:0100267)3.01570970
22Molar tooth sign on MRI (HP:0002419)2.97076386
23Abnormality of midbrain morphology (HP:0002418)2.97076386
24Cutaneous finger syndactyly (HP:0010554)2.96585882
25Renal dysplasia (HP:0000110)2.96107731
26Midline defect of the nose (HP:0004122)2.88835355
27Atrophic scars (HP:0001075)2.87262235
28Septo-optic dysplasia (HP:0100842)2.82160156
29Abnormality of the parietal bone (HP:0002696)2.80866994
30Parakeratosis (HP:0001036)2.80787525
31Chronic hepatic failure (HP:0100626)2.74813253
32Short 4th metacarpal (HP:0010044)2.74005975
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.74005975
34Aplasia cutis congenita (HP:0001057)2.73356982
35Cupped ear (HP:0000378)2.68814896
36Occipital encephalocele (HP:0002085)2.68564592
37Oligodontia (HP:0000677)2.68430882
38Abnormality of the renal collecting system (HP:0004742)2.67224445
39Cutaneous syndactyly (HP:0012725)2.64817082
40Nephronophthisis (HP:0000090)2.61299749
41Increased variability in muscle fiber diameter (HP:0003557)2.60684888
42Abnormality of the calf musculature (HP:0001430)2.60477418
43Exercise-induced myalgia (HP:0003738)2.56318980
44Myelomeningocele (HP:0002475)2.54395350
45Thin ribs (HP:0000883)2.53813423
46Genu recurvatum (HP:0002816)2.52111351
47Soft skin (HP:0000977)2.52007006
48Mildly elevated creatine phosphokinase (HP:0008180)2.51624700
49Bell-shaped thorax (HP:0001591)2.47918528
50Slender build (HP:0001533)2.47341333
51Chronic bronchitis (HP:0004469)2.47176056
52Round ear (HP:0100830)2.44123392
53Pterygium (HP:0001059)2.43797471
54Abnormality of skeletal muscle fiber size (HP:0012084)2.43322163
55Preauricular pit (HP:0004467)2.41751110
56Periauricular skin pits (HP:0100277)2.41751110
57Limb-girdle muscle atrophy (HP:0003797)2.40265978
58White forelock (HP:0002211)2.39541873
59Fatigable weakness (HP:0003473)2.38912748
60Abnormality of the neuromuscular junction (HP:0003398)2.38912748
61Mixed hearing impairment (HP:0000410)2.36857969
62Absent eyebrow (HP:0002223)2.33225121
63Anophthalmia (HP:0000528)2.32918187
64Hypoplastic left heart (HP:0004383)2.31853784
65Congenital sensorineural hearing impairment (HP:0008527)2.30074914
66Akinesia (HP:0002304)2.29594968
67Abnormality of the pulmonary veins (HP:0011718)2.28917842
68Distal arthrogryposis (HP:0005684)2.26221157
69Abnormality of incisor morphology (HP:0011063)2.24337868
70Embryonal renal neoplasm (HP:0011794)2.23973447
71Renal hypoplasia (HP:0000089)2.23530704
72Ulnar bowing (HP:0003031)2.22190656
73Abnormality of the nasal septum (HP:0000419)2.21619660
74Patchy hypopigmentation of hair (HP:0011365)2.20697473
75Nephroblastoma (Wilms tumor) (HP:0002667)2.20687537
76Aplasia/Hypoplasia of the tibia (HP:0005772)2.19793845
77Muscle fiber atrophy (HP:0100295)2.18939787
78Partial duplication of the phalanx of hand (HP:0009999)2.18678680
79Muscle hypertrophy of the lower extremities (HP:0008968)2.18174433
80Calf muscle hypertrophy (HP:0008981)2.17411434
81Fragile skin (HP:0001030)2.16204615
82Alacrima (HP:0000522)2.14410268
83Short tibia (HP:0005736)2.12555622
84Breech presentation (HP:0001623)2.11526636
85Gowers sign (HP:0003391)2.11373891
86Duplication of thumb phalanx (HP:0009942)2.11045322
87Synostosis involving the elbow (HP:0003938)2.10726049
88Humeroradial synostosis (HP:0003041)2.10726049
89Abnormality of dentin (HP:0010299)2.10459304
90Conical tooth (HP:0000698)2.10099930
91Malignant hyperthermia (HP:0002047)2.09599134
92Long nose (HP:0003189)2.09126485
93Aortic dissection (HP:0002647)2.07948433
94Vertebral arch anomaly (HP:0008438)2.07889351
95Absent/shortened dynein arms (HP:0200106)2.07745390
96Dynein arm defect of respiratory motile cilia (HP:0012255)2.07745390
97Abnormality of the calcaneus (HP:0008364)2.07709622
98Hypoplastic heart (HP:0001961)2.04772372
99Fibular hypoplasia (HP:0003038)2.04093663
100Anomalous pulmonary venous return (HP:0010772)2.03723989
101Vascular tortuosity (HP:0004948)2.03495594
102Atelectasis (HP:0100750)2.02606696
103Type 2 muscle fiber atrophy (HP:0003554)2.02215036
104Abnormality of the renal medulla (HP:0100957)2.00835341
105Mesomelia (HP:0003027)2.00375257
106Neonatal short-limb short stature (HP:0008921)2.00305984
107Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.00239176
108Duplicated collecting system (HP:0000081)2.00120263
109Myopathic facies (HP:0002058)1.99469965
110Slender long bone (HP:0003100)1.99315299
111Vaginal atresia (HP:0000148)1.99035941
112True hermaphroditism (HP:0010459)1.98517080
113Short middle phalanx of the 5th finger (HP:0004220)1.98224801
114Male infertility (HP:0003251)1.97977766
115Delayed gross motor development (HP:0002194)1.97938413
116Microglossia (HP:0000171)1.97086185
117Abnormality of the phalanges of the 2nd finger (HP:0009541)1.96963963
118Genital tract atresia (HP:0001827)1.96957516
119Abnormality of the columella (HP:0009929)1.96756833
120Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96281286
121Infantile muscular hypotonia (HP:0008947)1.96163442
122Upper motor neuron abnormality (HP:0002127)1.96056807
123Optic nerve hypoplasia (HP:0000609)1.95648324
124Popliteal pterygium (HP:0009756)1.95296922
125Absent septum pellucidum (HP:0001331)1.95199907
126Pulmonary artery stenosis (HP:0004415)1.94431516
127Abnormality of the phalanges of the 5th finger (HP:0004213)1.93638147
128Bronchiectasis (HP:0002110)1.92951504
129Abnormalities of placenta or umbilical cord (HP:0001194)1.92244136
130Abnormal ciliary motility (HP:0012262)1.91790377
131Absent phalangeal crease (HP:0006109)1.91241820
132Abnormality of the phalanges of the hallux (HP:0010057)1.90458819
133Focal motor seizures (HP:0011153)1.90066714
134Recurrent corneal erosions (HP:0000495)1.89306557
135Postural tremor (HP:0002174)1.89191898
136Failure to thrive in infancy (HP:0001531)1.88839031
137Arterial tortuosity (HP:0005116)1.88748554
138Ulnar deviation of the wrist (HP:0003049)1.88676920
139Nasal polyposis (HP:0100582)1.86450630
140Optic nerve coloboma (HP:0000588)1.86196479
141Abnormality of the antihelix (HP:0009738)1.84864775
142Scapular winging (HP:0003691)1.84457353
143Short palpebral fissure (HP:0012745)1.83701004
144Unilateral renal agenesis (HP:0000122)1.82683839
145Ectopic anus (HP:0004397)1.82490876
146Adducted thumb (HP:0001181)1.81628813
147Supernumerary bones of the axial skeleton (HP:0009144)1.81068557
148Decreased lacrimation (HP:0000633)1.80976008
149Partial duplication of thumb phalanx (HP:0009944)1.80268175
150Facial cleft (HP:0002006)1.79467641
151Vertebral clefting (HP:0008428)1.79304707
152Aplasia/Hypoplasia involving the musculature (HP:0001460)1.78951607
153Coronal craniosynostosis (HP:0004440)1.78554524
154Aplasia involving bones of the extremities (HP:0009825)1.77553197
155Aplasia involving bones of the upper limbs (HP:0009823)1.77553197
156Aplasia of the phalanges of the hand (HP:0009802)1.77553197
157Abnormality of the 4th metacarpal (HP:0010012)1.77066767
158Tracheomalacia (HP:0002779)1.76928165
159Short clavicles (HP:0000894)1.76669353
160Supernumerary ribs (HP:0005815)1.76172207
161Preaxial foot polydactyly (HP:0001841)1.75965006
162Persistence of primary teeth (HP:0006335)1.75828926
163Pancreatic fibrosis (HP:0100732)1.75562542
164Shallow orbits (HP:0000586)1.75208881
165Mitral valve prolapse (HP:0001634)1.74974277
166Abnormality of the middle phalanges of the toes (HP:0010183)1.74434751
167Abnormality of the septum pellucidum (HP:0007375)1.74408180
168Febrile seizures (HP:0002373)1.74160837
169Abnormal lung lobation (HP:0002101)1.73634018
170Preaxial hand polydactyly (HP:0001177)1.73465674
171Infertility (HP:0000789)1.73102452
172Hypoventilation (HP:0002791)1.72992173
173Intellectual disability, moderate (HP:0002342)1.72448561
174Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71972769
175Symphalangism affecting the phalanges of the hand (HP:0009773)1.71810008
176Aplasia/Hypoplasia of the fibula (HP:0006492)1.70348648
177Congenital hip dislocation (HP:0001374)1.70071256
178Renal agenesis (HP:0000104)1.69564602
179Vitreoretinal degeneration (HP:0000655)1.69362165
180Adrenal hypoplasia (HP:0000835)1.69261760
181Chorioretinal atrophy (HP:0000533)1.69110668
182Round face (HP:0000311)1.68904724
183Aplasia/Hypoplasia of the clavicles (HP:0006710)1.68849006
184Intestinal atresia (HP:0011100)1.68684552
185Aortic regurgitation (HP:0001659)1.68439154
186Trismus (HP:0000211)1.67443125
187Weak cry (HP:0001612)1.66705684
188Exercise-induced muscle cramps (HP:0003710)1.65712792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.87267823
2SIK13.81054797
3EPHA33.08684333
4MAP3K93.07288613
5LATS12.90149725
6MOS2.86621312
7TRIB32.72047446
8EEF2K2.63116440
9MKNK22.45680101
10MKNK12.41046352
11TNIK2.23758068
12EPHB22.16442472
13PRPF4B2.10608169
14TAOK12.10224972
15STK392.07185190
16CDK31.96145092
17OBSCN1.95390139
18BMPR1B1.94412963
19CDK121.92016288
20STK381.88557200
21PBK1.77690332
22DDR21.76933109
23NTRK11.73566460
24EPHA21.73255183
25NUAK11.70349546
26OXSR11.68830756
27SIK31.67348904
28YES11.67119745
29MAPK131.65101534
30AKT31.60556267
31CLK11.59958936
32TTN1.58952333
33LIMK11.48960964
34CDK81.46237231
35WNK11.42352897
36ERBB31.40381240
37PKN11.36980044
38BLK1.33696391
39EIF2AK21.33292799
40RIPK11.33017364
41NTRK31.32291908
42PKN21.32265568
43RPS6KA21.31517695
44PDK21.31482982
45ARAF1.29843362
46TESK11.28055426
47GRK71.24345126
48EPHA41.23256288
49NEK61.22876852
50BCR1.19271069
51STK38L1.16958502
52STK161.16933568
53PLK21.16706211
54NTRK21.15136801
55INSRR1.14412014
56MAP2K71.14328612
57MAPK151.10865428
58PNCK1.08324789
59BMPR21.04902948
60PRKCE1.04584687
61ADRBK21.04573642
62FGR1.03801609
63CSNK1A1L0.99424415
64DYRK20.96592251
65SMG10.95786650
66NME10.93904061
67GRK10.92470545
68FGFR20.90147635
69PTK20.88137373
70ZAK0.87154153
71WNK40.83680718
72SGK30.83414526
73LMTK20.82505779
74CDK190.82284259
75LATS20.81739679
76ABL20.81687390
77CAMK2B0.80229473
78PDGFRA0.79450585
79MAP2K10.77547802
80SRPK10.77259336
81ROCK20.75224516
82CAMK2A0.73954415
83ILK0.73768294
84ADRBK10.72268896
85MTOR0.71971916
86STK30.70681224
87MAPKAPK30.70431433
88PRKCI0.69778804
89UHMK10.68688990
90MAP3K20.65646692
91IRAK10.65099336
92SGK4940.64311910
93SGK2230.64311910
94PIM20.63384995
95AKT20.62390510
96DYRK1A0.61215176
97MAPK70.60508348
98CAMK1G0.58157588
99PIK3CG0.57658114
100CAMKK10.57157021
101VRK10.56388977
102PRKAA10.55908432
103ICK0.55394518
104TAOK20.54818626
105TSSK60.54411699
106WNK30.54207469
107TRPM70.53755244
108IRAK20.53603745
109MET0.53600742
110DYRK30.53540428
111CAMK2G0.53320970
112SCYL20.52912438
113MAP3K140.51887703
114SIK20.51824131
115PHKG20.51557156
116PHKG10.51557156
117PAK60.51284415
118MAPKAPK50.51252496
119CSNK1G30.51126228
120CSNK1G20.50296293
121RPS6KL10.49060469
122RPS6KC10.49060469
123PLK30.48865650
124TXK0.48813478
125HIPK20.48664390
126AURKA0.48632443
127MUSK0.48448347
128PRKG10.45831108
129PAK20.45413207
130MARK10.44801757
131MARK20.43755602
132PLK40.42677416
133PRKCZ0.42146900
134PRKCG0.41912263
135CSNK1G10.41823785
136NEK10.40814408
137FER0.40680180
138CAMK2D0.40258746
139TLK10.40183779
140RPS6KA60.40025809
141MST1R0.39002723
142MST40.38709998
143PTK2B0.38353753
144MAPK120.38333912
145PAK30.38152291
146LRRK20.38041989
147CCNB10.37479152
148ROCK10.37401499
149IRAK40.36431400
150BRD40.36280906
151CDK11A0.35969828
152SGK10.35517617
153SGK20.35500554
154CDK150.34843632
155CSNK1A10.34193749
156STK110.33876945
157CDK50.33869985
158DMPK0.32018278
159CDK180.31602918
160IRAK30.31475366
161CDK140.31316628
162RPS6KA40.30610916
163PDPK10.29610894
164MAPK90.29099547
165RPS6KB10.28948106
166PAK10.28040342
167STK100.27849986
168NME20.26406753
169MAPK100.24249820
170MELK0.24116364
171BRAF0.23519422

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.63687038
2Basal cell carcinoma_Homo sapiens_hsa052172.62667978
3Phototransduction_Homo sapiens_hsa047442.47478492
4Axon guidance_Homo sapiens_hsa043602.43905148
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.21845835
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.18622405
7Hedgehog signaling pathway_Homo sapiens_hsa043402.10447538
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96346539
9Serotonergic synapse_Homo sapiens_hsa047261.82486272
10Taste transduction_Homo sapiens_hsa047421.64519482
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63999172
12Wnt signaling pathway_Homo sapiens_hsa043101.63860093
13Morphine addiction_Homo sapiens_hsa050321.57630242
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.57585892
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54376145
16Autoimmune thyroid disease_Homo sapiens_hsa053201.53147892
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51241594
18Hippo signaling pathway_Homo sapiens_hsa043901.50041551
19Fructose and mannose metabolism_Homo sapiens_hsa000511.49402629
20Protein digestion and absorption_Homo sapiens_hsa049741.49214908
21mTOR signaling pathway_Homo sapiens_hsa041501.46226794
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45213227
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42399260
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42324232
25Glutamatergic synapse_Homo sapiens_hsa047241.40330848
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36319758
27Type II diabetes mellitus_Homo sapiens_hsa049301.34365536
28Ether lipid metabolism_Homo sapiens_hsa005651.34025348
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.33077222
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.29919943
31AMPK signaling pathway_Homo sapiens_hsa041521.27279821
32Fanconi anemia pathway_Homo sapiens_hsa034601.25156878
33Circadian entrainment_Homo sapiens_hsa047131.22851839
34GABAergic synapse_Homo sapiens_hsa047271.20240740
35Insulin signaling pathway_Homo sapiens_hsa049101.20230263
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20091055
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19219729
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18000818
39Phenylalanine metabolism_Homo sapiens_hsa003601.17487219
40Melanogenesis_Homo sapiens_hsa049161.17201232
41TGF-beta signaling pathway_Homo sapiens_hsa043501.16068210
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.15529714
43RNA polymerase_Homo sapiens_hsa030201.15491349
44Cardiac muscle contraction_Homo sapiens_hsa042601.14686874
45Calcium signaling pathway_Homo sapiens_hsa040201.11469932
46Steroid biosynthesis_Homo sapiens_hsa001001.07059307
47Pentose phosphate pathway_Homo sapiens_hsa000301.06587506
48ECM-receptor interaction_Homo sapiens_hsa045121.05022019
49Long-term depression_Homo sapiens_hsa047301.05006754
50Melanoma_Homo sapiens_hsa052181.01915635
51Arachidonic acid metabolism_Homo sapiens_hsa005901.00061216
52Vitamin B6 metabolism_Homo sapiens_hsa007500.99773770
53Fatty acid elongation_Homo sapiens_hsa000620.98952713
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98152149
55Sphingolipid metabolism_Homo sapiens_hsa006000.97640502
56Ovarian steroidogenesis_Homo sapiens_hsa049130.96300327
57Sulfur relay system_Homo sapiens_hsa041220.96274855
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94138198
59Renin secretion_Homo sapiens_hsa049240.93855269
60Rheumatoid arthritis_Homo sapiens_hsa053230.93102164
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91236876
62Graft-versus-host disease_Homo sapiens_hsa053320.89624349
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89072633
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89063850
65Amoebiasis_Homo sapiens_hsa051460.87212517
66Biosynthesis of amino acids_Homo sapiens_hsa012300.86747956
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86518251
68Salivary secretion_Homo sapiens_hsa049700.85955075
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85065859
70Glucagon signaling pathway_Homo sapiens_hsa049220.83795160
71Collecting duct acid secretion_Homo sapiens_hsa049660.83750500
72Cocaine addiction_Homo sapiens_hsa050300.83722798
73Oxidative phosphorylation_Homo sapiens_hsa001900.83233364
74Basal transcription factors_Homo sapiens_hsa030220.82134588
75Proteoglycans in cancer_Homo sapiens_hsa052050.81872937
76Olfactory transduction_Homo sapiens_hsa047400.81415179
77Ras signaling pathway_Homo sapiens_hsa040140.81095317
78Allograft rejection_Homo sapiens_hsa053300.80235312
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80175287
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.80135728
81Insulin resistance_Homo sapiens_hsa049310.79288307
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78710100
83Amphetamine addiction_Homo sapiens_hsa050310.78705608
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76563113
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76459187
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76275853
87Notch signaling pathway_Homo sapiens_hsa043300.76122894
88Retinol metabolism_Homo sapiens_hsa008300.76039933
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75437564
90Pathways in cancer_Homo sapiens_hsa052000.74852792
91Dilated cardiomyopathy_Homo sapiens_hsa054140.73838774
92Adherens junction_Homo sapiens_hsa045200.73737762
93Galactose metabolism_Homo sapiens_hsa000520.72270113
94Cholinergic synapse_Homo sapiens_hsa047250.70921332
95Folate biosynthesis_Homo sapiens_hsa007900.70144534
96Rap1 signaling pathway_Homo sapiens_hsa040150.69385036
97Non-homologous end-joining_Homo sapiens_hsa034500.68953114
98Dopaminergic synapse_Homo sapiens_hsa047280.68166100
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68069980
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.67352081
101MAPK signaling pathway_Homo sapiens_hsa040100.67178361
102cAMP signaling pathway_Homo sapiens_hsa040240.66874054
103Asthma_Homo sapiens_hsa053100.66270121
104Endometrial cancer_Homo sapiens_hsa052130.65664075
105Vibrio cholerae infection_Homo sapiens_hsa051100.65640356
106Synaptic vesicle cycle_Homo sapiens_hsa047210.65095369
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64276591
108Tyrosine metabolism_Homo sapiens_hsa003500.64258116
109Oxytocin signaling pathway_Homo sapiens_hsa049210.63505242
110Gap junction_Homo sapiens_hsa045400.63066679
111Chemical carcinogenesis_Homo sapiens_hsa052040.62893553
112Chronic myeloid leukemia_Homo sapiens_hsa052200.62039407
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61608749
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61003959
115Phagosome_Homo sapiens_hsa041450.60933753
116Prostate cancer_Homo sapiens_hsa052150.60853420
117Lysine degradation_Homo sapiens_hsa003100.60710954
118Alzheimers disease_Homo sapiens_hsa050100.60547914
119Glioma_Homo sapiens_hsa052140.60096266
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59763269
121MicroRNAs in cancer_Homo sapiens_hsa052060.59689703
122Arginine and proline metabolism_Homo sapiens_hsa003300.58830558
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58476429
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.58266899
125Renal cell carcinoma_Homo sapiens_hsa052110.57534339
126Linoleic acid metabolism_Homo sapiens_hsa005910.57475310
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57196998
128Regulation of autophagy_Homo sapiens_hsa041400.55709295
129SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54984301
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53418044
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52762282
132Spliceosome_Homo sapiens_hsa030400.52382602
133GnRH signaling pathway_Homo sapiens_hsa049120.50702997
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50424904
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50182355
136Protein export_Homo sapiens_hsa030600.49541249
137FoxO signaling pathway_Homo sapiens_hsa040680.49073546
138Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48534761
139Bladder cancer_Homo sapiens_hsa052190.48260063
140Huntingtons disease_Homo sapiens_hsa050160.48020938
141Carbon metabolism_Homo sapiens_hsa012000.47876318
142Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47766575
143Circadian rhythm_Homo sapiens_hsa047100.47691823
144Insulin secretion_Homo sapiens_hsa049110.46488880
145African trypanosomiasis_Homo sapiens_hsa051430.45568281
146Tight junction_Homo sapiens_hsa045300.45260970
147Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44937697
148ErbB signaling pathway_Homo sapiens_hsa040120.44480797
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42332513
150Long-term potentiation_Homo sapiens_hsa047200.42166613
151Focal adhesion_Homo sapiens_hsa045100.41714120
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41702529
153Homologous recombination_Homo sapiens_hsa034400.40633665
154Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40180377
155RNA degradation_Homo sapiens_hsa030180.39834418

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »