SIX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.91706061
2somite development (GO:0061053)5.05601121
3neuron cell-cell adhesion (GO:0007158)4.35092434
4vocalization behavior (GO:0071625)4.34380894
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.32950435
6dendritic spine morphogenesis (GO:0060997)4.27963783
7viral transcription (GO:0019083)4.27726583
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17008315
9ribosomal small subunit assembly (GO:0000028)4.13967845
10translational termination (GO:0006415)4.07864713
11positive regulation of synaptic transmission, GABAergic (GO:0032230)3.94851600
12protein localization to synapse (GO:0035418)3.94415390
13negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.89738067
14transmission of nerve impulse (GO:0019226)3.89734915
15* cell proliferation in forebrain (GO:0021846)3.89156252
16regulation of glutamate receptor signaling pathway (GO:1900449)3.87470542
17protein polyglutamylation (GO:0018095)3.85425380
18presynaptic membrane assembly (GO:0097105)3.81706371
19maturation of SSU-rRNA (GO:0030490)3.81523637
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80279210
21mitochondrial respiratory chain complex I assembly (GO:0032981)3.80279210
22NADH dehydrogenase complex assembly (GO:0010257)3.80279210
23water-soluble vitamin biosynthetic process (GO:0042364)3.79151537
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.74546053
25regulation of short-term neuronal synaptic plasticity (GO:0048172)3.72375353
26protein complex biogenesis (GO:0070271)3.71235462
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.70903846
28auditory behavior (GO:0031223)3.70778660
29ribosomal small subunit biogenesis (GO:0042274)3.70184252
30postsynaptic membrane organization (GO:0001941)3.69194780
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.66855628
32response to auditory stimulus (GO:0010996)3.63188165
33neurotransmitter-gated ion channel clustering (GO:0072578)3.60669325
34synaptic transmission, glutamatergic (GO:0035249)3.50174820
35presynaptic membrane organization (GO:0097090)3.42512766
36axoneme assembly (GO:0035082)3.40693957
37mitochondrial respiratory chain complex assembly (GO:0033108)3.39422979
38adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.38813963
39otic vesicle formation (GO:0030916)3.36285122
40neuron-neuron synaptic transmission (GO:0007270)3.32188516
41negative regulation of cytosolic calcium ion concentration (GO:0051481)3.27042252
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26693191
43response to histamine (GO:0034776)3.26485146
44pyrimidine nucleobase catabolic process (GO:0006208)3.25224095
45synaptic vesicle maturation (GO:0016188)3.24899922
46dentate gyrus development (GO:0021542)3.24834399
47translational elongation (GO:0006414)3.24792317
48cotranslational protein targeting to membrane (GO:0006613)3.24385390
49glutamate receptor signaling pathway (GO:0007215)3.23801290
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.20873938
51cilium movement (GO:0003341)3.17805360
52synaptic transmission, dopaminergic (GO:0001963)3.17458352
53protein targeting to ER (GO:0045047)3.17377892
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.17276305
55epithelial cilium movement (GO:0003351)3.16486150
56epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.15796284
57neuron recognition (GO:0008038)3.15468618
58striatum development (GO:0021756)3.14306708
59gamma-aminobutyric acid signaling pathway (GO:0007214)3.14136756
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12467534
61membrane hyperpolarization (GO:0060081)3.09835496
62dopamine receptor signaling pathway (GO:0007212)3.05624957
63appendage development (GO:0048736)3.05497667
64limb development (GO:0060173)3.05497667
65regulation of synaptic vesicle exocytosis (GO:2000300)3.04128959
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.03931474
67cellular protein complex disassembly (GO:0043624)3.03439196
68forebrain neuron differentiation (GO:0021879)3.03287036
69rhodopsin mediated signaling pathway (GO:0016056)3.02800294
70chaperone-mediated protein transport (GO:0072321)3.02542646
71DNA deamination (GO:0045006)3.02502911
72establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02099200
73prepulse inhibition (GO:0060134)3.01040186
74regulation of rhodopsin mediated signaling pathway (GO:0022400)3.00815877
75photoreceptor cell maintenance (GO:0045494)3.00780221
76central nervous system myelination (GO:0022010)3.00530029
77axon ensheathment in central nervous system (GO:0032291)3.00530029
78regulation of synapse structural plasticity (GO:0051823)3.00460287
79locomotory exploration behavior (GO:0035641)3.00348951
80negative regulation of transcription regulatory region DNA binding (GO:2000678)2.99697286
81regulation of synaptic transmission, glutamatergic (GO:0051966)2.99544602
82female mating behavior (GO:0060180)2.98569250
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98407398
84regulation of synaptic transmission, GABAergic (GO:0032228)2.97521622
85regulation of mesoderm development (GO:2000380)2.96207692
86protein neddylation (GO:0045116)2.96152566
87protein localization to endoplasmic reticulum (GO:0070972)2.95866543
88regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95603868
89viral life cycle (GO:0019058)2.94526240
90positive regulation of synapse assembly (GO:0051965)2.93043136
91regulation of neuronal synaptic plasticity (GO:0048168)2.90976845
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90841984
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90841984
94retinal ganglion cell axon guidance (GO:0031290)2.90688861
95axonal fasciculation (GO:0007413)2.90547134
96adult walking behavior (GO:0007628)2.89167188
97retinal rod cell development (GO:0046548)2.87550873
98synaptic vesicle exocytosis (GO:0016079)2.87349931
99regulation of glutamate secretion (GO:0014048)2.87006344
100gamma-aminobutyric acid transport (GO:0015812)2.86039157
101neuronal ion channel clustering (GO:0045161)2.85305247
102mechanosensory behavior (GO:0007638)2.84662853
103long-term memory (GO:0007616)2.84182830
104mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.82331300
105positive regulation of membrane potential (GO:0045838)2.82085499
106startle response (GO:0001964)2.80180122
107photoreceptor cell development (GO:0042461)2.79550033
108kynurenine metabolic process (GO:0070189)2.78348346
109response to pheromone (GO:0019236)2.78225593
110neuron fate determination (GO:0048664)2.77923249
111piRNA metabolic process (GO:0034587)2.77830033
112nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.76866774
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76827472
114cilium or flagellum-dependent cell motility (GO:0001539)2.76213203
115eye photoreceptor cell development (GO:0042462)2.76080974
116regulation of posttranscriptional gene silencing (GO:0060147)2.75502536
117regulation of gene silencing by miRNA (GO:0060964)2.75502536
118regulation of gene silencing by RNA (GO:0060966)2.75502536
119regulation of excitatory postsynaptic membrane potential (GO:0060079)2.75010630
120drinking behavior (GO:0042756)2.74948432
121nonmotile primary cilium assembly (GO:0035058)2.74416008
122G-protein coupled receptor internalization (GO:0002031)2.74373459
123cerebral cortex radially oriented cell migration (GO:0021799)2.73626915
124positive regulation of amino acid transport (GO:0051957)2.72439000
125indolalkylamine metabolic process (GO:0006586)2.72102483
126regulation of female receptivity (GO:0045924)2.72025108
127synapse assembly (GO:0007416)2.71430582
128limb bud formation (GO:0060174)2.70729318
129axonemal dynein complex assembly (GO:0070286)2.69570084
130neuronal action potential propagation (GO:0019227)2.69406156
131neurotransmitter secretion (GO:0007269)2.68558657
132negative regulation of response to food (GO:0032096)2.67878184
133negative regulation of appetite (GO:0032099)2.67878184
134retina layer formation (GO:0010842)2.67703486
135regulation of vesicle fusion (GO:0031338)2.65987250
136regulation of respiratory system process (GO:0044065)2.65347615
137regulation of postsynaptic membrane potential (GO:0060078)2.65315903
138positive regulation of dendritic spine development (GO:0060999)2.65241631
139protein complex disassembly (GO:0043241)2.64897385
140long-term synaptic potentiation (GO:0060291)2.64772599
141layer formation in cerebral cortex (GO:0021819)2.64641804
142behavioral fear response (GO:0001662)2.63864924
143behavioral defense response (GO:0002209)2.63864924
144learning (GO:0007612)2.63700194
145righting reflex (GO:0060013)2.63302502
146nucleobase catabolic process (GO:0046113)2.63102498
147nephron epithelium morphogenesis (GO:0072088)2.62371460
148nephron tubule morphogenesis (GO:0072078)2.62371460
149mating behavior (GO:0007617)2.62126738
150spinal cord development (GO:0021510)2.62026379
151spinal cord motor neuron differentiation (GO:0021522)2.61685084
152ATP synthesis coupled proton transport (GO:0015986)2.61659510
153energy coupled proton transport, down electrochemical gradient (GO:0015985)2.61659510
154regulation of cilium movement (GO:0003352)2.60540081
155response to amphetamine (GO:0001975)2.59865934
156tongue development (GO:0043586)2.59739086
157regulation of synaptic vesicle transport (GO:1902803)2.58709335
158substrate-independent telencephalic tangential migration (GO:0021826)2.57919813
159substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.57919813
160indolalkylamine catabolic process (GO:0046218)2.57351120
161tryptophan catabolic process (GO:0006569)2.57351120
162indole-containing compound catabolic process (GO:0042436)2.57351120
163negative regulation of neurotransmitter secretion (GO:0046929)2.56824767
164dendritic spine organization (GO:0097061)2.56720567
165protein-cofactor linkage (GO:0018065)2.55827409
166cornea development in camera-type eye (GO:0061303)2.55077310
167forebrain morphogenesis (GO:0048853)2.54537979
168sulfation (GO:0051923)2.54300979
169positive regulation of action potential (GO:0045760)2.54222825
170short-term memory (GO:0007614)2.53676902
171kidney morphogenesis (GO:0060993)2.52467652
172pharyngeal system development (GO:0060037)2.51090756
173DNA methylation involved in gamete generation (GO:0043046)2.50719857
174outer ear morphogenesis (GO:0042473)2.50289533
175macromolecular complex disassembly (GO:0032984)2.49785600
176negative regulation of astrocyte differentiation (GO:0048712)2.49439908
177male meiosis I (GO:0007141)2.48720470
178parturition (GO:0007567)2.48200042
179regulation of glomerulus development (GO:0090192)2.46860813
180synaptic transmission, cholinergic (GO:0007271)2.46164370
181segment specification (GO:0007379)2.45413614
182sperm motility (GO:0030317)2.45290657
183intraciliary transport (GO:0042073)2.44937955
184cardiovascular system development (GO:0072358)2.44645869
185regulation of action potential (GO:0098900)2.42014499
186regulation of non-canonical Wnt signaling pathway (GO:2000050)2.41273503
187olfactory bulb development (GO:0021772)2.41187385
188acrosome reaction (GO:0007340)2.38105790
189spinal cord association neuron differentiation (GO:0021527)2.37477934
190hypothalamus development (GO:0021854)2.34699431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.81658927
2GBX2_23144817_ChIP-Seq_PC3_Human3.24230374
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95656073
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.82207519
5ZNF274_21170338_ChIP-Seq_K562_Hela2.81667834
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.76292589
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72280972
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59327138
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59224657
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56984068
11* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56984068
12* EED_16625203_ChIP-ChIP_MESCs_Mouse2.52335565
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49502456
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48916756
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45881393
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36782098
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.35306083
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28009401
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.18494224
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15842334
21* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15687023
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15387992
23CBX2_27304074_Chip-Seq_ESCs_Mouse2.07603888
24TAF15_26573619_Chip-Seq_HEK293_Human2.05892781
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05080802
26REST_21632747_ChIP-Seq_MESCs_Mouse2.02864011
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97278513
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95023621
29* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87944916
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86312744
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.84924660
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83498624
33AR_21572438_ChIP-Seq_LNCaP_Human1.82320319
34* IRF1_19129219_ChIP-ChIP_H3396_Human1.76260149
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76239260
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74144937
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73855763
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71714745
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68750348
40DROSHA_22980978_ChIP-Seq_HELA_Human1.68478568
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.66302048
42* RNF2_27304074_Chip-Seq_NSC_Mouse1.66216660
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65459896
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63237139
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62523776
46* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61736311
47* MYC_18940864_ChIP-ChIP_HL60_Human1.59688274
48EWS_26573619_Chip-Seq_HEK293_Human1.57131378
49* P300_19829295_ChIP-Seq_ESCs_Human1.56986635
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56566642
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.51785360
52* SMAD3_21741376_ChIP-Seq_EPCs_Human1.45789054
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45733135
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.45564830
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42802630
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.40757159
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36161299
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33605583
59GABP_17652178_ChIP-ChIP_JURKAT_Human1.32454036
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.32213322
61* RING1B_27294783_Chip-Seq_NPCs_Mouse1.28784864
62ER_23166858_ChIP-Seq_MCF-7_Human1.28442496
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28303416
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28139413
65* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27418121
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26328978
67CBP_20019798_ChIP-Seq_JUKART_Human1.26328978
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25421323
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25067461
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24956040
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24841396
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23372058
73FUS_26573619_Chip-Seq_HEK293_Human1.23325314
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21820467
75TP53_22573176_ChIP-Seq_HFKS_Human1.20823516
76AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19715604
77AR_25329375_ChIP-Seq_VCAP_Human1.17022567
78IGF1R_20145208_ChIP-Seq_DFB_Human1.16992987
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15878967
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.15675869
81* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14283640
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.14188814
83BCAT_22108803_ChIP-Seq_LS180_Human1.13304278
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12801047
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12801047
86* SOX2_16153702_ChIP-ChIP_HESCs_Human1.12795260
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12510898
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.12281527
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11696626
90* NCOR_22424771_ChIP-Seq_293T_Human1.11517494
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11350280
92RUNX2_22187159_ChIP-Seq_PCA_Human1.10879960
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10484222
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.10429190
95VDR_22108803_ChIP-Seq_LS180_Human1.08378667
96GATA3_21878914_ChIP-Seq_MCF-7_Human1.07670105
97* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07656075
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07564691
99GATA1_26923725_Chip-Seq_HPCs_Mouse1.07546847
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07463066
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06784004
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06431912
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.05840997
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04891048
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.04643716
106TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04521845
107AHR_22903824_ChIP-Seq_MCF-7_Human1.03580567
108FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03431833
109FOXA1_25329375_ChIP-Seq_VCAP_Human1.03431833
110FLI1_27457419_Chip-Seq_LIVER_Mouse1.03410571
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03172937
112NANOG_19829295_ChIP-Seq_ESCs_Human1.02843969
113SOX2_19829295_ChIP-Seq_ESCs_Human1.02843969
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02348125
115P53_22387025_ChIP-Seq_ESCs_Mouse1.01932370
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01610163
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01322747
118STAT3_23295773_ChIP-Seq_U87_Human1.00925319
119* SMAD4_21741376_ChIP-Seq_EPCs_Human0.99828013
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.97881217
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.97597582
122SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97572916
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97446305
124TP53_18474530_ChIP-ChIP_U2OS_Human0.97276433
125ERG_21242973_ChIP-ChIP_JURKAT_Human0.97158252
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96987611
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96709162
128P300_18555785_Chip-Seq_ESCs_Mouse0.96514975
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96081431
130STAT3_18555785_Chip-Seq_ESCs_Mouse0.95811548
131* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94513016
132* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94423852
133* TP53_20018659_ChIP-ChIP_R1E_Mouse0.94387064
134* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93666485
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93664540
136TCF4_23295773_ChIP-Seq_U87_Human0.93181356
137NMYC_18555785_Chip-Seq_ESCs_Mouse0.92654565
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92091390

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.51797347
2MP0009379_abnormal_foot_pigmentation3.39518252
3MP0002822_catalepsy3.09797734
4MP0004859_abnormal_synaptic_plasticity2.97597683
5MP0008877_abnormal_DNA_methylation2.81861521
6MP0001984_abnormal_olfaction2.75676357
7MP0005551_abnormal_eye_electrophysiolog2.74617906
8MP0005646_abnormal_pituitary_gland2.73159674
9MP0003635_abnormal_synaptic_transmissio2.70775637
10MP0001486_abnormal_startle_reflex2.58122149
11MP0009745_abnormal_behavioral_response2.56425884
12MP0005423_abnormal_somatic_nervous2.55722440
13MP0006072_abnormal_retinal_apoptosis2.53098153
14* MP0006292_abnormal_olfactory_placode2.51730243
15MP0009046_muscle_twitch2.43190420
16MP0003136_yellow_coat_color2.42495618
17MP0005645_abnormal_hypothalamus_physiol2.35233691
18MP0001968_abnormal_touch/_nociception2.34181197
19MP0001188_hyperpigmentation2.33570898
20MP0002064_seizures2.32678170
21MP0005409_darkened_coat_color2.29757750
22MP0002837_dystrophic_cardiac_calcinosis2.26942616
23MP0002063_abnormal_learning/memory/cond2.25601524
24MP0005253_abnormal_eye_physiology2.16704374
25MP0002572_abnormal_emotion/affect_behav2.12275417
26MP0002272_abnormal_nervous_system2.08616290
27MP0001293_anophthalmia2.07990455
28MP0002638_abnormal_pupillary_reflex2.07887528
29MP0000778_abnormal_nervous_system2.04422800
30MP0001529_abnormal_vocalization2.03213372
31MP0005499_abnormal_olfactory_system1.98717910
32MP0005394_taste/olfaction_phenotype1.98717910
33MP0008789_abnormal_olfactory_epithelium1.93681240
34MP0003646_muscle_fatigue1.90183523
35MP0001346_abnormal_lacrimal_gland1.88512108
36MP0004270_analgesia1.85751068
37MP0002557_abnormal_social/conspecific_i1.84795126
38MP0002734_abnormal_mechanical_nocicepti1.83405511
39MP0001502_abnormal_circadian_rhythm1.82714167
40MP0004885_abnormal_endolymph1.73686616
41MP0004742_abnormal_vestibular_system1.73324760
42MP0001501_abnormal_sleep_pattern1.73005141
43MP0002160_abnormal_reproductive_system1.71350176
44MP0003122_maternal_imprinting1.69517526
45MP0000631_abnormal_neuroendocrine_gland1.68140676
46MP0002938_white_spotting1.65366503
47MP0002067_abnormal_sensory_capabilities1.65360953
48MP0003878_abnormal_ear_physiology1.62844742
49MP0005377_hearing/vestibular/ear_phenot1.62844742
50MP0003787_abnormal_imprinting1.61964493
51MP0004133_heterotaxia1.61245916
52MP0002736_abnormal_nociception_after1.59624518
53MP0006276_abnormal_autonomic_nervous1.58319359
54MP0003690_abnormal_glial_cell1.55419568
55MP0010030_abnormal_orbit_morphology1.46260934
56MP0002735_abnormal_chemical_nociception1.45604646
57MP0002882_abnormal_neuron_morphology1.40995953
58MP0005386_behavior/neurological_phenoty1.40536409
59MP0004924_abnormal_behavior1.40536409
60MP0002102_abnormal_ear_morphology1.38789422
61MP0002733_abnormal_thermal_nociception1.37883039
62MP0005195_abnormal_posterior_eye1.37845246
63MP0002184_abnormal_innervation1.37652573
64MP0003011_delayed_dark_adaptation1.36467425
65MP0003123_paternal_imprinting1.36056143
66MP0001970_abnormal_pain_threshold1.36028658
67MP0002752_abnormal_somatic_nervous1.34452676
68MP0005389_reproductive_system_phenotype1.33840118
69MP0001440_abnormal_grooming_behavior1.31239048
70MP0004142_abnormal_muscle_tone1.29651703
71MP0001485_abnormal_pinna_reflex1.28288196
72MP0001905_abnormal_dopamine_level1.27594125
73MP0002277_abnormal_respiratory_mucosa1.27530252
74MP0002090_abnormal_vision1.27216938
75MP0002234_abnormal_pharynx_morphology1.26227309
76MP0005379_endocrine/exocrine_gland_phen1.24946852
77MP0003119_abnormal_digestive_system1.22563497
78MP0000026_abnormal_inner_ear1.22536932
79MP0003937_abnormal_limbs/digits/tail_de1.20707283
80MP0003938_abnormal_ear_development1.20280208
81MP0001963_abnormal_hearing_physiology1.19926632
82MP0005410_abnormal_fertilization1.17262337
83MP0002229_neurodegeneration1.17122246
84MP0008569_lethality_at_weaning1.14834116
85MP0005248_abnormal_Harderian_gland1.14542713
86MP0004145_abnormal_muscle_electrophysio1.14418352
87MP0000566_synostosis1.14367328
88MP0002138_abnormal_hepatobiliary_system1.10659875
89MP0003283_abnormal_digestive_organ1.09646853
90MP0000049_abnormal_middle_ear1.09491367
91MP0003942_abnormal_urinary_system1.03369840
92MP0001986_abnormal_taste_sensitivity1.02039343
93MP0003195_calcinosis1.01831522
94MP0005171_absent_coat_pigmentation1.01773395
95MP0000955_abnormal_spinal_cord1.01651513
96MP0005391_vision/eye_phenotype1.01507876
97MP0002066_abnormal_motor_capabilities/c1.00743626
98MP0002163_abnormal_gland_morphology0.98524832
99MP0004811_abnormal_neuron_physiology0.97764751
100* MP0002152_abnormal_brain_morphology0.97037263
101MP0002210_abnormal_sex_determination0.95849456
102MP0005084_abnormal_gallbladder_morpholo0.95655166
103MP0000678_abnormal_parathyroid_gland0.95145751
104MP0009053_abnormal_anal_canal0.94441844
105MP0003698_abnormal_male_reproductive0.94044964
106MP0003634_abnormal_glial_cell0.93977290
107MP0002653_abnormal_ependyma_morphology0.91109162
108MP0002697_abnormal_eye_size0.89871195
109MP0000920_abnormal_myelination0.86995114
110MP0003633_abnormal_nervous_system0.85392299
111* MP0001286_abnormal_eye_development0.84816969
112MP0003755_abnormal_palate_morphology0.84567484
113MP0001919_abnormal_reproductive_system0.84442893
114MP0001929_abnormal_gametogenesis0.83574176
115MP0003121_genomic_imprinting0.82574908
116MP0003890_abnormal_embryonic-extraembry0.82188912
117MP0001177_atelectasis0.80371706
118MP0003567_abnormal_fetal_cardiomyocyte0.80148526
119MP0000653_abnormal_sex_gland0.80113477
120MP0002876_abnormal_thyroid_physiology0.78503527
121MP0002249_abnormal_larynx_morphology0.75020221
122MP0008995_early_reproductive_senescence0.75004791
123MP0009250_abnormal_appendicular_skeleto0.74817179
124MP0002233_abnormal_nose_morphology0.74706498
125MP0001324_abnormal_eye_pigmentation0.73191278
126MP0004381_abnormal_hair_follicle0.72972625
127MP0002751_abnormal_autonomic_nervous0.69927693
128* MP0003861_abnormal_nervous_system0.66233198
129MP0002069_abnormal_eating/drinking_beha0.65179625
130MP0008872_abnormal_physiological_respon0.65066046
131MP0003879_abnormal_hair_cell0.64445368
132MP0005197_abnormal_uvea_morphology0.64216885
133MP0002909_abnormal_adrenal_gland0.62606524
134MP0005623_abnormal_meninges_morphology0.61942835

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.92829433
2Abnormal ciliary motility (HP:0012262)4.83124915
3Congenital stationary night blindness (HP:0007642)4.60766960
4Myokymia (HP:0002411)4.22348779
5Abnormal respiratory motile cilium physiology (HP:0012261)4.12257495
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.90831170
7Absent/shortened dynein arms (HP:0200106)3.90831170
8Pancreatic cysts (HP:0001737)3.61936443
9Decreased central vision (HP:0007663)3.60427090
10Abnormal respiratory motile cilium morphology (HP:0005938)3.55469013
11Abnormal respiratory epithelium morphology (HP:0012253)3.55469013
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.44470576
13Febrile seizures (HP:0002373)3.43878605
14Nuclear cataract (HP:0100018)3.43527983
15Reticulocytopenia (HP:0001896)3.19774547
16Zonular cataract (HP:0010920)3.15432945
17Abnormal rod and cone electroretinograms (HP:0008323)3.14890268
18Central scotoma (HP:0000603)3.14367041
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.04056787
20Abnormality of macular pigmentation (HP:0008002)3.03720291
21Septo-optic dysplasia (HP:0100842)3.03158600
22Focal seizures (HP:0007359)3.03123464
23Severe visual impairment (HP:0001141)3.01378441
24Bony spicule pigmentary retinopathy (HP:0007737)2.96826168
25Epileptic encephalopathy (HP:0200134)2.87448320
26Anophthalmia (HP:0000528)2.85683836
27Abolished electroretinogram (ERG) (HP:0000550)2.82397983
28Abnormality of cells of the erythroid lineage (HP:0012130)2.79742871
29Gait imbalance (HP:0002141)2.79500197
30Maternal diabetes (HP:0009800)2.78085269
31Congenital primary aphakia (HP:0007707)2.75996091
32Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.75526249
33Rib fusion (HP:0000902)2.69155394
34Drooling (HP:0002307)2.69026342
35Excessive salivation (HP:0003781)2.69026342
36Chorioretinal atrophy (HP:0000533)2.68919275
37Acute necrotizing encephalopathy (HP:0006965)2.68386906
38Pendular nystagmus (HP:0012043)2.67610631
39Broad-based gait (HP:0002136)2.62761839
40Megalencephaly (HP:0001355)2.61827445
41Medial flaring of the eyebrow (HP:0010747)2.61669065
42Abnormal number of erythroid precursors (HP:0012131)2.59884884
43Generalized tonic-clonic seizures (HP:0002069)2.55846444
44Rhinitis (HP:0012384)2.55143503
45Dyschromatopsia (HP:0007641)2.48008998
46Stenosis of the external auditory canal (HP:0000402)2.47038509
47Progressive cerebellar ataxia (HP:0002073)2.42978606
48Nephrogenic diabetes insipidus (HP:0009806)2.42044249
49Polyphagia (HP:0002591)2.41681482
50Hyperglycinemia (HP:0002154)2.41676961
51Scotoma (HP:0000575)2.40528686
52Hemiparesis (HP:0001269)2.40068344
53Aplasia involving bones of the upper limbs (HP:0009823)2.39850499
54Aplasia of the phalanges of the hand (HP:0009802)2.39850499
55Aplasia involving bones of the extremities (HP:0009825)2.39850499
56Atelectasis (HP:0100750)2.37768281
57Absent thumb (HP:0009777)2.35380681
58Absence seizures (HP:0002121)2.33472619
59Cystic liver disease (HP:0006706)2.33303694
60Abnormal mitochondria in muscle tissue (HP:0008316)2.30592875
61True hermaphroditism (HP:0010459)2.29051068
62Acute encephalopathy (HP:0006846)2.28094665
63Genital tract atresia (HP:0001827)2.26365555
64Genetic anticipation (HP:0003743)2.26217810
65Mitochondrial inheritance (HP:0001427)2.25922227
66Chronic hepatic failure (HP:0100626)2.25146748
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.24353536
68Progressive macrocephaly (HP:0004481)2.23345508
69Anencephaly (HP:0002323)2.22029420
70Increased corneal curvature (HP:0100692)2.21114292
71Keratoconus (HP:0000563)2.21114292
72Attenuation of retinal blood vessels (HP:0007843)2.20547317
73Abnormality of the proximal phalanges of the hand (HP:0009834)2.19996205
74Type II lissencephaly (HP:0007260)2.18748225
75Anxiety (HP:0000739)2.18741834
76Vaginal atresia (HP:0000148)2.16898654
77Tubular atrophy (HP:0000092)2.16306698
78Asplenia (HP:0001746)2.14185661
79Aplasia/Hypoplasia of the lens (HP:0008063)2.13838565
80Abnormal drinking behavior (HP:0030082)2.12756984
81Polydipsia (HP:0001959)2.12756984
82Aplasia/Hypoplasia of the tongue (HP:0010295)2.12756214
83Male pseudohermaphroditism (HP:0000037)2.12584256
84Dialeptic seizures (HP:0011146)2.12571161
85Nephronophthisis (HP:0000090)2.11308195
86* Median cleft lip (HP:0000161)2.11294149
87Pancreatic fibrosis (HP:0100732)2.09956158
88Abnormality of midbrain morphology (HP:0002418)2.09807875
89Molar tooth sign on MRI (HP:0002419)2.09807875
90Specific learning disability (HP:0001328)2.07894847
91Colon cancer (HP:0003003)2.07888648
92Abnormality of salivation (HP:0100755)2.07086837
93Postaxial foot polydactyly (HP:0001830)2.06711326
94Abnormality of secondary sexual hair (HP:0009888)2.05885713
95Abnormality of the axillary hair (HP:0100134)2.05885713
96Abnormality of the renal cortex (HP:0011035)2.04144672
97Visual hallucinations (HP:0002367)2.04053045
98Renal dysplasia (HP:0000110)2.04007054
99Atonic seizures (HP:0010819)2.03078272
100Ectopic kidney (HP:0000086)2.03073480
101Absent septum pellucidum (HP:0001331)2.02329982
102Abnormality of binocular vision (HP:0011514)2.01355028
103Diplopia (HP:0000651)2.01355028
104Amblyopia (HP:0000646)2.01216045
105Narrow nasal bridge (HP:0000446)2.01104608
106Abnormality of the phalanges of the 5th finger (HP:0004213)2.00945764
107Humeroradial synostosis (HP:0003041)1.99481200
108Synostosis involving the elbow (HP:0003938)1.99481200
109Methylmalonic acidemia (HP:0002912)1.99291455
110Abnormal eating behavior (HP:0100738)1.97774683
111Increased CSF lactate (HP:0002490)1.97184902
112Hyperventilation (HP:0002883)1.94467797
113Agitation (HP:0000713)1.93895580
114Macrocytic anemia (HP:0001972)1.92606993
115Oligodactyly (hands) (HP:0001180)1.91027742
116Optic nerve hypoplasia (HP:0000609)1.90835181
1173-Methylglutaconic aciduria (HP:0003535)1.90635454
118Corneal dystrophy (HP:0001131)1.90470836
119Photophobia (HP:0000613)1.89630959
120Abnormality of cochlea (HP:0000375)1.88050502
121Macular degeneration (HP:0000608)1.87816381
122Abnormality of the middle phalanges of the toes (HP:0010183)1.87028604
123Aplasia/Hypoplasia of the fovea (HP:0008060)1.86840912
124Hypoplasia of the fovea (HP:0007750)1.86840912
125Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86753077
126Action tremor (HP:0002345)1.85701961
127Congenital hepatic fibrosis (HP:0002612)1.84936294
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83433851
129Degeneration of the lateral corticospinal tracts (HP:0002314)1.83433851
130Aplasia/Hypoplasia of the hallux (HP:0008362)1.82801732
131Short femoral neck (HP:0100864)1.82269877
132Abnormality of the 4th metacarpal (HP:0010012)1.81479180
133Split foot (HP:0001839)1.81077108
134Urinary bladder sphincter dysfunction (HP:0002839)1.80931696
135Abnormality of the septum pellucidum (HP:0007375)1.80654382
136Limb dystonia (HP:0002451)1.80542116
137Abnormality of the renal collecting system (HP:0004742)1.80482140
138Abnormality of the renal medulla (HP:0100957)1.79066873
139Morphological abnormality of the middle ear (HP:0008609)1.78714729
140Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.77457178
141Retinitis pigmentosa (HP:0000510)1.77343083
142Optic disc pallor (HP:0000543)1.77292330
143Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77033914
144Hypothermia (HP:0002045)1.76772143
145Synostosis of carpal bones (HP:0005048)1.76618645
146Short hallux (HP:0010109)1.76611449
147Postaxial hand polydactyly (HP:0001162)1.76580087
148Polyuria (HP:0000103)1.75367479
149Congenital, generalized hypertrichosis (HP:0004540)1.75006918
150Prolonged QT interval (HP:0001657)1.74871629
151Thyroid-stimulating hormone excess (HP:0002925)1.74767403
152Short 4th metacarpal (HP:0010044)1.74404694
153Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74404694
154Bronchomalacia (HP:0002780)1.74126369
155Hypoplasia of the ulna (HP:0003022)1.73444560
156Preaxial hand polydactyly (HP:0001177)1.73260621
157Dysdiadochokinesis (HP:0002075)1.73100203
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.72618627
159Abnormality of the labia minora (HP:0012880)1.71748237
160Poor coordination (HP:0002370)1.71054306
161Spastic gait (HP:0002064)1.68158586
162Abnormal hair whorl (HP:0010721)1.67240679
163Sclerocornea (HP:0000647)1.66746710

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.65664129
2EPHA43.66199626
3FRK3.39078186
4CASK3.17815881
5TNIK3.09940909
6PRPF4B2.92433720
7MARK12.69541193
8NTRK32.54741003
9ZAK2.37047786
10TLK12.28055778
11NTRK22.25777339
12MAP4K22.14833452
13MAP2K71.92168795
14TNK21.90800781
15STK161.83986016
16BCKDK1.83497293
17CDC71.73175020
18WNK41.69858066
19FES1.68874022
20NUAK11.66876505
21GRK11.66415956
22MAPK131.63964481
23SIK21.61732185
24IRAK21.60006823
25TIE11.51181884
26SGK4941.43688591
27SGK2231.43688591
28PLK41.43470176
29MAP3K41.41894554
30PLK21.41048885
31MAP3K121.36880985
32TAOK31.35999609
33PASK1.33242382
34SIK31.31835508
35PNCK1.29946279
36PKN11.28646817
37SGK21.24667848
38ACVR1B1.20410870
39BMPR21.20184522
40MARK21.18224798
41NEK61.14919241
42AKT31.14204166
43MKNK21.13762919
44MINK11.12840332
45TYRO31.12241036
46ADRBK21.10883704
47BCR1.08018844
48LMTK21.06729282
49PIK3CA1.04242024
50OXSR11.01892713
51CDK51.01134653
52AURKA0.98584403
53PHKG10.98562885
54PHKG20.98562885
55MAPK150.97945041
56CSNK1G20.97044945
57VRK10.95314117
58PRKD20.95140135
59CDK30.94685638
60IRAK10.94507060
61TXK0.94259785
62CAMK10.93446078
63PAK30.91634518
64PAK60.91434645
65UHMK10.90700471
66DYRK30.90387332
67EPHB20.88598323
68PRKCE0.87112909
69RPS6KA20.85304515
70YES10.84639661
71STK38L0.84540415
72PRKCG0.84043892
73ERBB30.82842019
74CSNK1G30.81415349
75DYRK1A0.81315256
76BLK0.81147405
77ADRBK10.80762850
78CAMK2A0.80523956
79CSNK1G10.80269092
80MAPK70.80087746
81MKNK10.79832779
82PRKD30.79419545
83TAOK20.78953567
84PINK10.78787422
85PLK10.78616112
86DAPK20.77433161
87SGK30.77358817
88RIPK40.77145070
89TRIM280.76857150
90MAP2K20.74489980
91SGK10.73106969
92TAF10.72736851
93STK390.72715246
94MUSK0.72001422
95MAP3K90.69372730
96CAMK40.68900848
97CDK190.68679425
98NEK20.68667054
99MST40.68342638
100PRKCI0.67646213
101CSNK1A10.66508029
102CAMK2B0.64977781
103STK110.62526318
104BMPR1B0.61430497
105CHEK20.60982078
106PLK30.60710015
107HIPK20.60491169
108CAMK1G0.60174438
109CAMK2D0.59952482
110MAP3K20.59620096
111CAMKK10.59617065
112GRK70.59374283
113RPS6KA60.58971770
114PRKG10.58847862
115PRKCH0.56769760
116CLK10.56353363
117ARAF0.56209442
118LIMK10.55343669
119PRKCZ0.54725550
120WNK30.54323263
121STK30.53216544
122DYRK20.52531980
123MAP2K40.52484565
124RPS6KA50.51961166
125ROCK10.51009518
126PRKCQ0.49908849
127CSNK1A1L0.49613869
128KSR10.49434656
129MAP3K70.49330492
130ROCK20.48746289
131TEC0.48064398
132ERBB20.47276924
133IRAK40.47232640
134TGFBR10.46854570
135RPS6KL10.45801894
136RPS6KC10.45801894
137FGFR20.44442282
138VRK20.43083161
139PRKACA0.43009327
140GRK50.42341620
141MAP3K130.42287435
142AURKB0.41001503
143PRKCA0.40869717
144FYN0.40605369
145CSNK1E0.39003821
146BRAF0.38870530
147ATR0.37627580
148ABL20.36682237
149CSNK2A10.35243039

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.13831025
2Phototransduction_Homo sapiens_hsa047444.12563604
3Nicotine addiction_Homo sapiens_hsa050333.86405770
4GABAergic synapse_Homo sapiens_hsa047273.11028373
5Olfactory transduction_Homo sapiens_hsa047402.88734848
6Morphine addiction_Homo sapiens_hsa050322.84933356
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.56055899
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.36136536
9Glutamatergic synapse_Homo sapiens_hsa047242.34693076
10Circadian entrainment_Homo sapiens_hsa047132.32950037
11Synaptic vesicle cycle_Homo sapiens_hsa047212.27317325
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22394299
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.21900165
14Linoleic acid metabolism_Homo sapiens_hsa005912.06932822
15Serotonergic synapse_Homo sapiens_hsa047262.05065285
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.94624809
17RNA polymerase_Homo sapiens_hsa030201.82917950
18Taste transduction_Homo sapiens_hsa047421.82762617
19Sulfur relay system_Homo sapiens_hsa041221.80795162
20Cholinergic synapse_Homo sapiens_hsa047251.79968074
21Amphetamine addiction_Homo sapiens_hsa050311.78050949
22Dopaminergic synapse_Homo sapiens_hsa047281.76277240
23Cocaine addiction_Homo sapiens_hsa050301.76174210
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.74031883
25Protein export_Homo sapiens_hsa030601.66680692
26Homologous recombination_Homo sapiens_hsa034401.63350748
27Renin secretion_Homo sapiens_hsa049241.62283642
28Axon guidance_Homo sapiens_hsa043601.60994500
29Salivary secretion_Homo sapiens_hsa049701.57249054
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55431739
31Butanoate metabolism_Homo sapiens_hsa006501.55378681
32Tryptophan metabolism_Homo sapiens_hsa003801.52002811
33Nitrogen metabolism_Homo sapiens_hsa009101.48339983
34RNA degradation_Homo sapiens_hsa030181.46292068
35Insulin secretion_Homo sapiens_hsa049111.44698397
36Fanconi anemia pathway_Homo sapiens_hsa034601.44398113
37Cardiac muscle contraction_Homo sapiens_hsa042601.41969263
38Gastric acid secretion_Homo sapiens_hsa049711.41901083
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.40928460
40Calcium signaling pathway_Homo sapiens_hsa040201.39947671
41Oxytocin signaling pathway_Homo sapiens_hsa049211.37672940
42Oxidative phosphorylation_Homo sapiens_hsa001901.37459820
43Basal transcription factors_Homo sapiens_hsa030221.35394358
44Long-term depression_Homo sapiens_hsa047301.33958923
45Retinol metabolism_Homo sapiens_hsa008301.33608767
46Long-term potentiation_Homo sapiens_hsa047201.31520055
47Collecting duct acid secretion_Homo sapiens_hsa049661.29231132
48Selenocompound metabolism_Homo sapiens_hsa004501.18371585
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16731448
50Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16557365
51cAMP signaling pathway_Homo sapiens_hsa040241.15547631
52Parkinsons disease_Homo sapiens_hsa050121.11100061
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09466606
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09115108
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08671371
56Caffeine metabolism_Homo sapiens_hsa002321.07200795
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06059482
58Chemical carcinogenesis_Homo sapiens_hsa052041.03412750
59Alzheimers disease_Homo sapiens_hsa050101.01125724
60Gap junction_Homo sapiens_hsa045401.00028315
61Fat digestion and absorption_Homo sapiens_hsa049750.99925767
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99504204
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98303817
64GnRH signaling pathway_Homo sapiens_hsa049120.97061553
65Melanogenesis_Homo sapiens_hsa049160.95053810
66Circadian rhythm_Homo sapiens_hsa047100.94476312
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.93776023
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93770349
69ErbB signaling pathway_Homo sapiens_hsa040120.92484396
70Ether lipid metabolism_Homo sapiens_hsa005650.89593760
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89412120
72Type I diabetes mellitus_Homo sapiens_hsa049400.86657449
73Rheumatoid arthritis_Homo sapiens_hsa053230.86605616
74Steroid biosynthesis_Homo sapiens_hsa001000.85710524
75Peroxisome_Homo sapiens_hsa041460.83702757
76Dilated cardiomyopathy_Homo sapiens_hsa054140.83685190
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83532470
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.82236227
79MAPK signaling pathway_Homo sapiens_hsa040100.82003080
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80713862
81Huntingtons disease_Homo sapiens_hsa050160.80643137
82Glycerolipid metabolism_Homo sapiens_hsa005610.79824878
83Ras signaling pathway_Homo sapiens_hsa040140.78036168
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77931125
85Wnt signaling pathway_Homo sapiens_hsa043100.76051336
86Pyrimidine metabolism_Homo sapiens_hsa002400.75780226
87Propanoate metabolism_Homo sapiens_hsa006400.74685752
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74608631
89Hippo signaling pathway_Homo sapiens_hsa043900.74019872
90beta-Alanine metabolism_Homo sapiens_hsa004100.73252281
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72835541
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.72365673
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71873023
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71025798
95Graft-versus-host disease_Homo sapiens_hsa053320.70703529
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70426397
97Ovarian steroidogenesis_Homo sapiens_hsa049130.70402137
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70166853
99Renal cell carcinoma_Homo sapiens_hsa052110.70092863
100Hedgehog signaling pathway_Homo sapiens_hsa043400.69934784
101Sulfur metabolism_Homo sapiens_hsa009200.67195399
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66639004
103Vibrio cholerae infection_Homo sapiens_hsa051100.66429001
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.65874368
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65513552
106Purine metabolism_Homo sapiens_hsa002300.64911262
107Alcoholism_Homo sapiens_hsa050340.63724163
108Fatty acid degradation_Homo sapiens_hsa000710.63688552
109Regulation of autophagy_Homo sapiens_hsa041400.63618476
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63113585
111Metabolic pathways_Homo sapiens_hsa011000.62300271
112Type II diabetes mellitus_Homo sapiens_hsa049300.61943951
113Choline metabolism in cancer_Homo sapiens_hsa052310.60853812
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60338479
115Estrogen signaling pathway_Homo sapiens_hsa049150.59409580
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.58194659
117Mismatch repair_Homo sapiens_hsa034300.54982968
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52402510
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52231638
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51959965
121Basal cell carcinoma_Homo sapiens_hsa052170.50338195
122Vitamin digestion and absorption_Homo sapiens_hsa049770.49735782
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49481156
124Nucleotide excision repair_Homo sapiens_hsa034200.49133301
125Chemokine signaling pathway_Homo sapiens_hsa040620.48848787
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47460328
127Pancreatic secretion_Homo sapiens_hsa049720.47372051
128Dorso-ventral axis formation_Homo sapiens_hsa043200.47225757
129Rap1 signaling pathway_Homo sapiens_hsa040150.46242003
130Autoimmune thyroid disease_Homo sapiens_hsa053200.46007136
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.44806005
132Melanoma_Homo sapiens_hsa052180.43252631
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41633077
134Prion diseases_Homo sapiens_hsa050200.40900782
135RNA transport_Homo sapiens_hsa030130.40144925
136Systemic lupus erythematosus_Homo sapiens_hsa053220.39828049
137African trypanosomiasis_Homo sapiens_hsa051430.39280620
138Sphingolipid metabolism_Homo sapiens_hsa006000.39253947
139Folate biosynthesis_Homo sapiens_hsa007900.38570318
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37377797
141Arginine and proline metabolism_Homo sapiens_hsa003300.36662415
142Glioma_Homo sapiens_hsa052140.34059051
143Tyrosine metabolism_Homo sapiens_hsa003500.33266226
144Sphingolipid signaling pathway_Homo sapiens_hsa040710.29901633
145Endometrial cancer_Homo sapiens_hsa052130.29715276
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29056878
147Asthma_Homo sapiens_hsa053100.28396309
148Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27877667
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27866199
150Allograft rejection_Homo sapiens_hsa053300.27439149
151T cell receptor signaling pathway_Homo sapiens_hsa046600.26024173
152Phagosome_Homo sapiens_hsa041450.25820617
153Colorectal cancer_Homo sapiens_hsa052100.23984718
154Arachidonic acid metabolism_Homo sapiens_hsa005900.23822516
155Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23596643

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