SIX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cardioblast proliferation (GO:0003264)4.41628276
2regulation of secondary heart field cardioblast proliferation (GO:0003266)4.41628276
3nuclear pore organization (GO:0006999)4.14239929
4paraxial mesoderm development (GO:0048339)4.08849540
5nuclear pore complex assembly (GO:0051292)4.06696575
6regulation of helicase activity (GO:0051095)3.82134400
7axonemal dynein complex assembly (GO:0070286)3.80013130
8regulation of posttranscriptional gene silencing (GO:0060147)3.72361448
9regulation of gene silencing by miRNA (GO:0060964)3.72361448
10regulation of gene silencing by RNA (GO:0060966)3.72361448
11pharyngeal system development (GO:0060037)3.68625520
12replicative senescence (GO:0090399)3.42738888
13outer ear morphogenesis (GO:0042473)3.27725934
14regulation of nuclear cell cycle DNA replication (GO:0033262)3.20337237
15neuron fate specification (GO:0048665)3.19786886
16cilium or flagellum-dependent cell motility (GO:0001539)3.14613428
17negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.11923414
18pore complex assembly (GO:0046931)3.06569820
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.01111065
20muscle filament sliding (GO:0030049)3.00943255
21actin-myosin filament sliding (GO:0033275)3.00943255
22establishment or maintenance of monopolar cell polarity (GO:0061339)2.96466268
23establishment of monopolar cell polarity (GO:0061162)2.96466268
24DNA double-strand break processing (GO:0000729)2.96139190
25protein localization to kinetochore (GO:0034501)2.93323664
26microtubule depolymerization (GO:0007019)2.92685773
27* myoblast migration (GO:0051451)2.92634882
28IMP metabolic process (GO:0046040)2.90942114
29regulation of transforming growth factor beta2 production (GO:0032909)2.90061400
30protein K6-linked ubiquitination (GO:0085020)2.89033095
31heterochromatin organization (GO:0070828)2.87398297
32kinetochore organization (GO:0051383)2.87038535
33negative regulation of keratinocyte proliferation (GO:0010839)2.86953960
34notochord development (GO:0030903)2.84900285
35hippo signaling (GO:0035329)2.84560658
36protein localization to microtubule (GO:0035372)2.81714506
37cilium movement (GO:0003341)2.81415640
38* generation of neurons (GO:0048699)2.78181315
39motile cilium assembly (GO:0044458)2.76844509
40actin-mediated cell contraction (GO:0070252)2.75402650
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.75166206
42regulation of telomere maintenance via telomerase (GO:0032210)2.74904132
43regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74797326
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73629161
45middle ear morphogenesis (GO:0042474)2.73275381
46regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.70980328
47negative regulation of glycogen biosynthetic process (GO:0045719)2.70815778
48skeletal muscle contraction (GO:0003009)2.68750941
49pre-miRNA processing (GO:0031054)2.68278429
50DNA strand renaturation (GO:0000733)2.67545580
51regulation of gene silencing (GO:0060968)2.67519477
52intestinal epithelial cell development (GO:0060576)2.65758583
53regulation of histone H3-K9 methylation (GO:0051570)2.65702316
54metaphase plate congression (GO:0051310)2.64535510
55negative regulation of DNA-dependent DNA replication (GO:2000104)2.63835352
56protein localization to chromosome, centromeric region (GO:0071459)2.63458269
57regulation of mitotic spindle checkpoint (GO:1903504)2.63012351
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.63012351
59protein complex localization (GO:0031503)2.59765882
60mitotic metaphase plate congression (GO:0007080)2.58671969
61kinetochore assembly (GO:0051382)2.58150848
62epithelial cell maturation (GO:0002070)2.57796610
63regulation of hippo signaling (GO:0035330)2.56995565
64mitotic chromosome condensation (GO:0007076)2.56747777
65mitotic sister chromatid segregation (GO:0000070)2.56115446
66protein K11-linked deubiquitination (GO:0035871)2.55238243
67meiotic chromosome segregation (GO:0045132)2.55072015
68ER overload response (GO:0006983)2.54963475
69protein localization to microtubule cytoskeleton (GO:0072698)2.54579960
70anterior/posterior axis specification, embryo (GO:0008595)2.54354422
71embryonic digit morphogenesis (GO:0042733)2.54146332
72ganglion development (GO:0061548)2.54065615
73sister chromatid segregation (GO:0000819)2.53560789
74NLS-bearing protein import into nucleus (GO:0006607)2.53550998
75rRNA methylation (GO:0031167)2.53156068
76DNA synthesis involved in DNA repair (GO:0000731)2.52777715
77establishment of integrated proviral latency (GO:0075713)2.52505317
78negative regulation of meiosis (GO:0045835)2.52283212
79snRNA processing (GO:0016180)2.51792291
80regulation of centrosome duplication (GO:0010824)2.51723597
81regulation of centrosome cycle (GO:0046605)2.51660072
82DNA replication checkpoint (GO:0000076)2.50166285
83regulation of cardioblast differentiation (GO:0051890)2.48776882
84peripheral nervous system neuron development (GO:0048935)2.47506793
85cullin deneddylation (GO:0010388)2.46522316
86* metanephric mesenchyme development (GO:0072075)2.45896845
87negative regulation of stem cell proliferation (GO:2000647)2.44765073
88negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.44184900
89DNA unwinding involved in DNA replication (GO:0006268)2.44086860
90epithelial cilium movement (GO:0003351)2.43378279
91chromatin remodeling at centromere (GO:0031055)2.41827778
92establishment of chromosome localization (GO:0051303)2.41469126
93intra-S DNA damage checkpoint (GO:0031573)2.41429284
94positive regulation of SMAD protein import into nucleus (GO:0060391)2.41050276
95somatic diversification of immune receptors via somatic mutation (GO:0002566)2.40736447
96somatic hypermutation of immunoglobulin genes (GO:0016446)2.40736447
97negative regulation of DNA repair (GO:0045738)2.40185627
98prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.40052762
99response to muscle activity (GO:0014850)2.39995792
100IMP biosynthetic process (GO:0006188)2.39786960
101regulation of heart morphogenesis (GO:2000826)2.37478807
102CENP-A containing nucleosome assembly (GO:0034080)2.36633393
103RNA-dependent DNA replication (GO:0006278)2.36310642
104plasma membrane repair (GO:0001778)2.35918621
105G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.34589151
106cellular protein complex localization (GO:0034629)2.34216551
107intraciliary transport (GO:0042073)2.33760045
108regulation of organ formation (GO:0003156)2.33327343
109spindle checkpoint (GO:0031577)2.32994368
110* kidney mesenchyme development (GO:0072074)2.32633279
111cranial suture morphogenesis (GO:0060363)2.32555324
112response to X-ray (GO:0010165)2.31415574
113planar cell polarity pathway involved in neural tube closure (GO:0090179)2.31409026
114spindle assembly checkpoint (GO:0071173)2.30303740
115protein localization to cytoskeleton (GO:0044380)2.29908187
116sarcoplasmic reticulum calcium ion transport (GO:0070296)2.29174116
117cochlea morphogenesis (GO:0090103)2.28680598
118cranial nerve development (GO:0021545)2.28543869
119negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.28476228
120replication fork processing (GO:0031297)2.27256970
121histone-serine phosphorylation (GO:0035404)2.27066981
122Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.26912354
123positive regulation of smoothened signaling pathway (GO:0045880)2.26898719
124daunorubicin metabolic process (GO:0044597)2.26473264
125polyketide metabolic process (GO:0030638)2.26473264
126doxorubicin metabolic process (GO:0044598)2.26473264
127* muscle cell migration (GO:0014812)2.25238091
128regulation of centriole replication (GO:0046599)2.24808756
129cellular response to ATP (GO:0071318)2.24599505
130branching involved in prostate gland morphogenesis (GO:0060442)2.24138321
131positive regulation of chromosome segregation (GO:0051984)2.24094569
132* embryonic cranial skeleton morphogenesis (GO:0048701)2.23726313
133embryonic process involved in female pregnancy (GO:0060136)2.23356973
134regulation of mesoderm development (GO:2000380)2.23064204
135regulation of establishment of planar polarity (GO:0090175)2.22531894
136organ induction (GO:0001759)2.22438588
137ribosome assembly (GO:0042255)2.22125253
138establishment of apical/basal cell polarity (GO:0035089)2.22099413
139convergent extension (GO:0060026)2.22062218
140histone H4-K12 acetylation (GO:0043983)2.21912435
141rRNA modification (GO:0000154)2.21579971
142regulation of chromatin silencing (GO:0031935)2.21510042
143DNA replication-dependent nucleosome organization (GO:0034723)2.21419881
144DNA replication-dependent nucleosome assembly (GO:0006335)2.21419881
145cytidine metabolic process (GO:0046087)2.21103971
146cytidine catabolic process (GO:0006216)2.21103971
147cytidine deamination (GO:0009972)2.21103971
148mitotic spindle assembly checkpoint (GO:0007094)2.20647073
149developmental induction (GO:0031128)2.20243313
150regulation of development, heterochronic (GO:0040034)2.20192877
151mitotic sister chromatid cohesion (GO:0007064)2.19939132
152microtubule polymerization or depolymerization (GO:0031109)2.19892926
153regulation of mitotic spindle organization (GO:0060236)2.19727086
154regulation of keratinocyte proliferation (GO:0010837)2.19576447
155negative regulation of chondrocyte differentiation (GO:0032331)2.18974219
156regulation of DNA endoreduplication (GO:0032875)2.18942364
157negative regulation of embryonic development (GO:0045992)2.18196528
158regulation of translational fidelity (GO:0006450)2.17665565
159regulation of cell fate specification (GO:0042659)2.17176147
160trophoblast giant cell differentiation (GO:0060707)2.16754596
161positive regulation of catenin import into nucleus (GO:0035413)2.16602798
162embryonic skeletal joint morphogenesis (GO:0060272)2.15982732
163regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.15704323
164negative regulation of cell fate commitment (GO:0010454)2.15202166
165mitotic nuclear envelope disassembly (GO:0007077)2.15193576
166regulation of spindle organization (GO:0090224)2.14903280
167UDP-N-acetylglucosamine metabolic process (GO:0006047)2.14223244
168cell-cell signaling involved in cell fate commitment (GO:0045168)2.13681189
169embryonic forelimb morphogenesis (GO:0035115)2.12953228
170establishment of tissue polarity (GO:0007164)2.12814967
171establishment of planar polarity (GO:0001736)2.12814967
172DNA strand elongation involved in DNA replication (GO:0006271)2.12788428
173forelimb morphogenesis (GO:0035136)2.12180941

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.98463395
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.75858865
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.29000681
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.10045310
5* KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.12099203
6* KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.12099203
7* KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.12099203
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.86291976
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.55851031
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51919670
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.50442098
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.28748733
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.23257141
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19166145
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.16236951
16SOX2_18555785_ChIP-Seq_MESCs_Mouse2.01454687
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.93465833
18ELK1_19687146_ChIP-ChIP_HELA_Human1.88933615
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88143891
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84331986
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.82202461
22HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.76301640
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76169463
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76063140
25POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.71290329
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.69182089
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.67350454
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66430030
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.64825105
30FOXM1_26456572_ChIP-Seq_MCF-7_Human1.63658338
31* E2F1_21310950_ChIP-Seq_MCF-7_Human1.62503648
32TCF3_18692474_ChIP-Seq_MESCs_Mouse1.61076346
33ESR1_21235772_ChIP-Seq_MCF-7_Human1.60701334
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.58009656
35SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.55827551
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.54474376
37ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.50772367
38* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50003022
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48283738
40EWS_26573619_Chip-Seq_HEK293_Human1.48153919
41FUS_26573619_Chip-Seq_HEK293_Human1.43218871
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42373980
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42326866
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41866844
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41078273
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.40765367
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38514169
48GBX2_23144817_ChIP-Seq_PC3_Human1.37028420
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36163890
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34526705
51NANOG_16153702_ChIP-ChIP_HESCs_Human1.33600862
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.32759860
53NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31591176
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30128127
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28984739
56SOX2_16153702_ChIP-ChIP_HESCs_Human1.28347784
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27522552
58MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26566634
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.26312245
60NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.26090851
61SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.25672477
62ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24494558
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22678539
64* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19348422
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.16319827
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16110633
67EP300_21415370_ChIP-Seq_HL-1_Mouse1.16009886
68CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15289825
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15148308
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14181780
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13587775
72FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13287237
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13254613
74EST1_17652178_ChIP-ChIP_JURKAT_Human1.10648669
75NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09718534
76DCP1A_22483619_ChIP-Seq_HELA_Human1.09364988
77POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08992121
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08235076
79* CHD1_26751641_Chip-Seq_LNCaP_Human1.07981472
80RNF2_27304074_Chip-Seq_NSC_Mouse1.07708526
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07504680
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06849619
83MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05759815
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05643274
85VDR_22108803_ChIP-Seq_LS180_Human1.04820223
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03164741
87TTF2_22483619_ChIP-Seq_HELA_Human1.02637885
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02261567
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01876990
90ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00820634
91ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98927673
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98581064
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.98494075
94XRN2_22483619_ChIP-Seq_HELA_Human0.97254808
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97248070
96MYC_18940864_ChIP-ChIP_HL60_Human0.96970303
97GABP_17652178_ChIP-ChIP_JURKAT_Human0.96544714
98FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95336970
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94924074
100* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94708670
101ZNF263_19887448_ChIP-Seq_K562_Human0.94109920
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.94094552
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93647344
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93647344
105GATA3_24758297_ChIP-Seq_MCF-7_Human0.93392678
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93024701
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92439768
108SOX17_20123909_ChIP-Seq_XEN_Mouse0.92153032
109MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91829114
110CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91579063
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90563584
112* NANOG_16518401_ChIP-PET_MESCs_Mouse0.90433310
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.89681142
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89178306
115TBX3_20139965_ChIP-Seq_MESCs_Mouse0.89144096
116TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87258640
117ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86908901
118TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86885818
119TP53_18474530_ChIP-ChIP_U2OS_Human0.86440711
120ZNF274_21170338_ChIP-Seq_K562_Hela0.86184817
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.86122747
122AR_21909140_ChIP-Seq_LNCAP_Human0.86114210
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85749568
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85559785
125PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85382895
126AHR_22903824_ChIP-Seq_MCF-7_Human0.84996969
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84885674
128* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84806212
129EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84788657
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84658006
131BRD4_25478319_ChIP-Seq_HGPS_Human0.84188700
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83016477
133* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.82996947
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81712814
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.81710279

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.66399909
2MP0002877_abnormal_melanocyte_morpholog3.28243774
3MP0003941_abnormal_skin_development3.04231051
4MP0008789_abnormal_olfactory_epithelium2.55016784
5MP0001986_abnormal_taste_sensitivity2.35850035
6MP0000678_abnormal_parathyroid_gland2.31022667
7MP0001346_abnormal_lacrimal_gland2.21707178
8MP0002009_preneoplasia2.20780445
9MP0000749_muscle_degeneration2.17884588
10MP0003693_abnormal_embryo_hatching2.09552546
11MP0000733_abnormal_muscle_development2.09134457
12MP0010094_abnormal_chromosome_stability2.06577070
13MP0000751_myopathy2.04813454
14MP0003890_abnormal_embryonic-extraembry2.01746774
15MP0000566_synostosis1.98552559
16MP0008057_abnormal_DNA_replication1.97458542
17MP0000049_abnormal_middle_ear1.94832125
18MP0001188_hyperpigmentation1.94364569
19MP0003646_muscle_fatigue1.94175961
20MP0002163_abnormal_gland_morphology1.90832921
21MP0006292_abnormal_olfactory_placode1.89001132
22MP0009780_abnormal_chondrocyte_physiolo1.87370324
23MP0004233_abnormal_muscle_weight1.84180656
24MP0008058_abnormal_DNA_repair1.82588793
25MP0004145_abnormal_muscle_electrophysio1.81115830
26MP0002277_abnormal_respiratory_mucosa1.77841889
27MP0001485_abnormal_pinna_reflex1.77510741
28MP0003937_abnormal_limbs/digits/tail_de1.76358125
29MP0005367_renal/urinary_system_phenotyp1.72991566
30MP0000516_abnormal_urinary_system1.72991566
31MP0000613_abnormal_salivary_gland1.71800124
32MP0002108_abnormal_muscle_morphology1.68863599
33MP0002233_abnormal_nose_morphology1.64892661
34MP0005499_abnormal_olfactory_system1.63482142
35MP0005394_taste/olfaction_phenotype1.63482142
36MP0008007_abnormal_cellular_replicative1.60915163
37MP0003111_abnormal_nucleus_morphology1.60888653
38MP0009250_abnormal_appendicular_skeleto1.58298113
39MP0003755_abnormal_palate_morphology1.56388840
40MP0009053_abnormal_anal_canal1.55558620
41MP0002938_white_spotting1.54943940
42MP0002751_abnormal_autonomic_nervous1.53730308
43MP0005623_abnormal_meninges_morphology1.53244469
44MP0001293_anophthalmia1.51138005
45MP0004272_abnormal_basement_membrane1.50366924
46MP0002653_abnormal_ependyma_morphology1.49663984
47MP0000762_abnormal_tongue_morphology1.47569294
48MP0003121_genomic_imprinting1.45878471
49MP0003705_abnormal_hypodermis_morpholog1.45734680
50MP0003942_abnormal_urinary_system1.45354072
51MP0000372_irregular_coat_pigmentation1.43913414
52MP0003136_yellow_coat_color1.42775355
53MP0003385_abnormal_body_wall1.37356975
54MP0001270_distended_abdomen1.35544615
55MP0004087_abnormal_muscle_fiber1.35327660
56MP0000759_abnormal_skeletal_muscle1.35090550
57MP0003077_abnormal_cell_cycle1.34966538
58MP0006072_abnormal_retinal_apoptosis1.32564188
59MP0005503_abnormal_tendon_morphology1.31942934
60MP0009697_abnormal_copulation1.29705469
61MP0009672_abnormal_birth_weight1.29358964
62MP0008438_abnormal_cutaneous_collagen1.29142625
63MP0005248_abnormal_Harderian_gland1.29104437
64MP0008932_abnormal_embryonic_tissue1.28128372
65MP0004036_abnormal_muscle_relaxation1.27634499
66MP0002249_abnormal_larynx_morphology1.27404782
67MP0005379_endocrine/exocrine_gland_phen1.26650126
68MP0003786_premature_aging1.26257618
69MP0003123_paternal_imprinting1.25625192
70MP0004957_abnormal_blastocyst_morpholog1.24613697
71MP0002177_abnormal_outer_ear1.23923662
72MP0001299_abnormal_eye_distance/1.23079198
73MP0002269_muscular_atrophy1.22712136
74MP0000537_abnormal_urethra_morphology1.21718404
75MP0002160_abnormal_reproductive_system1.20827441
76MP0000534_abnormal_ureter_morphology1.20623048
77MP0000432_abnormal_head_morphology1.20594057
78MP0005171_absent_coat_pigmentation1.19139924
79MP0003935_abnormal_craniofacial_develop1.16624608
80MP0005369_muscle_phenotype1.16608888
81MP0010352_gastrointestinal_tract_polyps1.15046271
82MP0003315_abnormal_perineum_morphology1.14468105
83MP0004134_abnormal_chest_morphology1.14371050
84MP0003950_abnormal_plasma_membrane1.14298802
85MP0002234_abnormal_pharynx_morphology1.13052922
86MP0001661_extended_life_span1.12034285
87MP0003283_abnormal_digestive_organ1.11253377
88MP0004185_abnormal_adipocyte_glucose1.10905272
89MP0002116_abnormal_craniofacial_bone1.10407113
90MP0003119_abnormal_digestive_system1.09862142
91MP0010386_abnormal_urinary_bladder1.09575378
92MP0002282_abnormal_trachea_morphology1.07947254
93MP0002085_abnormal_embryonic_tissue1.07097119
94MP0005508_abnormal_skeleton_morphology1.06822739
95MP0001286_abnormal_eye_development1.05461404
96MP0000747_muscle_weakness1.04480812
97MP0002106_abnormal_muscle_physiology1.04418759
98MP0000467_abnormal_esophagus_morphology1.03846411
99MP0004084_abnormal_cardiac_muscle1.03426748
100MP0003787_abnormal_imprinting1.03379386
101MP0000383_abnormal_hair_follicle1.02749251
102MP0000579_abnormal_nail_morphology1.02374459
103MP0002084_abnormal_developmental_patter1.01639016
104MP0000428_abnormal_craniofacial_morphol1.01543708
105MP0001984_abnormal_olfaction1.01025936
106MP0010307_abnormal_tumor_latency1.00598871
107MP0005187_abnormal_penis_morphology0.99951054
108MP0002109_abnormal_limb_morphology0.98425235
109MP0004197_abnormal_fetal_growth/weight/0.98327415
110MP0004133_heterotaxia0.98207079
111MP0000350_abnormal_cell_proliferation0.98171031
112MP0003115_abnormal_respiratory_system0.98005872
113MP0000750_abnormal_muscle_regeneration0.97320381
114MP0002114_abnormal_axial_skeleton0.95767331
115MP0001697_abnormal_embryo_size0.95697251
116MP0003984_embryonic_growth_retardation0.95139811
117MP0009703_decreased_birth_body0.93958987
118MP0000631_abnormal_neuroendocrine_gland0.93929748
119MP0002088_abnormal_embryonic_growth/wei0.93479258
120MP0010678_abnormal_skin_adnexa0.93009906
121MP0002932_abnormal_joint_morphology0.92612507
122MP0004782_abnormal_surfactant_physiolog0.92219022
123MP0001730_embryonic_growth_arrest0.91867038
124MP0002254_reproductive_system_inflammat0.91337910
125MP0001186_pigmentation_phenotype0.91270772
126MP0005389_reproductive_system_phenotype0.90145271
127MP0005620_abnormal_muscle_contractility0.89692854
128MP0003718_maternal_effect0.89495901
129MP0002735_abnormal_chemical_nociception0.88247390
130MP0005380_embryogenesis_phenotype0.88079224
131MP0001672_abnormal_embryogenesis/_devel0.88079224
132MP0003122_maternal_imprinting0.87604931
133MP0005377_hearing/vestibular/ear_phenot0.86996189
134MP0003878_abnormal_ear_physiology0.86996189
135MP0000026_abnormal_inner_ear0.86085108
136MP0001919_abnormal_reproductive_system0.85974849
137MP0005220_abnormal_exocrine_pancreas0.85392482
138MP0002111_abnormal_tail_morphology0.83695802
139MP0002080_prenatal_lethality0.82249090
140MP0002132_abnormal_respiratory_system0.82226584
141MP0002697_abnormal_eye_size0.80871998

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)5.13276645
2Muscle fiber inclusion bodies (HP:0100299)4.94991133
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.88235316
4Type 1 muscle fiber predominance (HP:0003803)3.98212850
5Abnormality of cochlea (HP:0000375)3.80285466
6Lip pit (HP:0100267)3.79317727
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.74102653
8Calcaneovalgus deformity (HP:0001848)3.64200650
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.34871686
10Absent/shortened dynein arms (HP:0200106)3.34871686
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.31937670
12Deformed tarsal bones (HP:0008119)3.27756066
13Chronic bronchitis (HP:0004469)3.17211461
14Exercise-induced muscle cramps (HP:0003710)3.17037899
15Chromsome breakage (HP:0040012)3.15642738
16Abnormal respiratory epithelium morphology (HP:0012253)3.14012884
17Abnormal respiratory motile cilium morphology (HP:0005938)3.14012884
18Osteomalacia (HP:0002749)3.10772334
19Abnormal respiratory motile cilium physiology (HP:0012261)3.00110439
20Hypothermia (HP:0002045)2.91634679
21Distal arthrogryposis (HP:0005684)2.87290117
22Rhinitis (HP:0012384)2.84619761
23Abnormal ciliary motility (HP:0012262)2.84454169
24Intestinal atresia (HP:0011100)2.74920202
25Papillary thyroid carcinoma (HP:0002895)2.71665003
26Absent eyebrow (HP:0002223)2.68955565
27Mesomelia (HP:0003027)2.67882596
28Bifid tongue (HP:0010297)2.61635188
29Muscle hypertrophy of the lower extremities (HP:0008968)2.52218329
30Morphological abnormality of the inner ear (HP:0011390)2.47898304
31Exercise-induced myalgia (HP:0003738)2.45026821
32Calf muscle hypertrophy (HP:0008981)2.40448278
33Abnormality of the calcaneus (HP:0008364)2.37054177
34Popliteal pterygium (HP:0009756)2.37003520
35Abnormality of the nasal septum (HP:0000419)2.34710560
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.34249090
37Abnormality of the ischium (HP:0003174)2.28323066
38Abnormality of the calf musculature (HP:0001430)2.27541238
39Thyroid carcinoma (HP:0002890)2.27179571
40Shawl scrotum (HP:0000049)2.27078692
41Abnormality of the right ventricle (HP:0001707)2.26785091
42Meckel diverticulum (HP:0002245)2.25008410
43Absent phalangeal crease (HP:0006109)2.23463071
44Facial cleft (HP:0002006)2.21438217
45Nephroblastoma (Wilms tumor) (HP:0002667)2.17956334
46Round ear (HP:0100830)2.16049504
47Abnormal lung lobation (HP:0002101)2.14918742
48Cutaneous finger syndactyly (HP:0010554)2.13545968
49Renal hypoplasia (HP:0000089)2.13205908
50Premature rupture of membranes (HP:0001788)2.11518770
51Abnormality of the ileum (HP:0001549)2.11368216
52Ectopic kidney (HP:0000086)2.10576338
53Abnormality of chromosome stability (HP:0003220)2.07463773
54Curly hair (HP:0002212)2.07184064
55Aplasia of the musculature (HP:0100854)2.07178563
56Midline defect of the nose (HP:0004122)2.06610567
57Myopathic facies (HP:0002058)2.05990880
58Cystic hygroma (HP:0000476)2.05769049
59Abnormal biliary tract morphology (HP:0012440)2.05656910
60Embryonal renal neoplasm (HP:0011794)2.03994895
61Hypoplasia of the fovea (HP:0007750)2.03841288
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.03841288
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.03235915
64Supernumerary spleens (HP:0009799)2.02384546
65Ulnar deviation of the wrist (HP:0003049)2.00953339
66Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.99277281
67Abnormality of the labia minora (HP:0012880)1.98965360
68Abnormality of the renal collecting system (HP:0004742)1.98382532
69Progressive muscle weakness (HP:0003323)1.97743256
70Short tibia (HP:0005736)1.97188746
71Pterygium (HP:0001059)1.96025466
72Anal stenosis (HP:0002025)1.95850380
73Tubulointerstitial nephritis (HP:0001970)1.95202988
74Anophthalmia (HP:0000528)1.93094524
75Microglossia (HP:0000171)1.92627171
76Fibular hypoplasia (HP:0003038)1.92264351
77Abnormal finger flexion creases (HP:0006143)1.91761689
78Cutaneous syndactyly (HP:0012725)1.91740840
79Median cleft lip (HP:0000161)1.87875403
80Neoplasm of the thyroid gland (HP:0100031)1.87489435
81Rectal prolapse (HP:0002035)1.87381903
82Short humerus (HP:0005792)1.86975701
83Rimmed vacuoles (HP:0003805)1.85426246
84Aplasia/Hypoplasia of the sternum (HP:0006714)1.85058741
85Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.83718472
86Absent radius (HP:0003974)1.82729189
87Submucous cleft hard palate (HP:0000176)1.82611722
88Abnormality of the preputium (HP:0100587)1.82603338
89Selective tooth agenesis (HP:0001592)1.82486310
90Short middle phalanx of the 5th finger (HP:0004220)1.81657741
91Breech presentation (HP:0001623)1.80916966
92Aplasia/hypoplasia of the humerus (HP:0006507)1.80618580
93Abnormality of the nasolacrimal system (HP:0000614)1.80318185
94Gastrointestinal atresia (HP:0002589)1.79013064
95Spinal rigidity (HP:0003306)1.78435128
96Abnormal number of incisors (HP:0011064)1.77135535
97Rib fusion (HP:0000902)1.77045144
98Bell-shaped thorax (HP:0001591)1.76970997
99Medulloblastoma (HP:0002885)1.76021445
100Distal lower limb muscle weakness (HP:0009053)1.75098758
101Ependymoma (HP:0002888)1.74482213
102Urethral obstruction (HP:0000796)1.74385380
103Periauricular skin pits (HP:0100277)1.74089889
104Preauricular pit (HP:0004467)1.74089889
105Abnormality of the lacrimal duct (HP:0011481)1.73884220
106Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.73411029
107Morphological abnormality of the middle ear (HP:0008609)1.72875113
108Glioma (HP:0009733)1.72253595
109Abnormality of chloride homeostasis (HP:0011422)1.71324563
110Aplasia/Hypoplasia of the fibula (HP:0006492)1.69686788
111Hyperkalemia (HP:0002153)1.66244077
112Arterial tortuosity (HP:0005116)1.65938078
113Hypoplastic ischia (HP:0003175)1.65719257
114Rhabdomyosarcoma (HP:0002859)1.65460287
115Birth length less than 3rd percentile (HP:0003561)1.65443794
116Bronchiectasis (HP:0002110)1.64895287
117Absent forearm bone (HP:0003953)1.64613041
118Aplasia involving forearm bones (HP:0009822)1.64613041
119Duodenal stenosis (HP:0100867)1.64519720
120Small intestinal stenosis (HP:0012848)1.64519720
121Abnormality of the left ventricular outflow tract (HP:0011103)1.63843658
122Subaortic stenosis (HP:0001682)1.63843658
123Aplasia/Hypoplasia of the patella (HP:0006498)1.62719428
124Abnormality of the phalanges of the 5th finger (HP:0004213)1.61922497
125Increased number of teeth (HP:0011069)1.61589534
126Short palpebral fissure (HP:0012745)1.61447884
127Abnormality of the duodenum (HP:0002246)1.60722672
128Bilateral microphthalmos (HP:0007633)1.60647111
129EMG: myopathic abnormalities (HP:0003458)1.60574555
130Intestinal fistula (HP:0100819)1.60441067
131Missing ribs (HP:0000921)1.60389888
132Synostosis of carpal bones (HP:0005048)1.59298459
133Impulsivity (HP:0100710)1.59170863
134Down-sloping shoulders (HP:0200021)1.58972797
135Neck muscle weakness (HP:0000467)1.58832909
136Ectopic anus (HP:0004397)1.58275684
137Renal dysplasia (HP:0000110)1.58162706
138Stenosis of the external auditory canal (HP:0000402)1.57610343
139Rectal fistula (HP:0100590)1.57564979
140Rectovaginal fistula (HP:0000143)1.57564979
141Areflexia of lower limbs (HP:0002522)1.57263664
142Absent eyelashes (HP:0000561)1.56987913
143Mildly elevated creatine phosphokinase (HP:0008180)1.56621663
144Fibular aplasia (HP:0002990)1.56303511
145Adrenal hypoplasia (HP:0000835)1.56193764
146Atresia of the external auditory canal (HP:0000413)1.55761098
147Colon cancer (HP:0003003)1.54916925
148Pancreatic fibrosis (HP:0100732)1.54886355
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.50047864
150Hip contracture (HP:0003273)1.49851360
151Septate vagina (HP:0001153)1.49678751
152Abnormality of the astrocytes (HP:0100707)1.49058532
153Astrocytoma (HP:0009592)1.49058532
154Vascular tortuosity (HP:0004948)1.48917695
155Limb-girdle muscle atrophy (HP:0003797)1.47828936
156Protrusio acetabuli (HP:0003179)1.47023772
157Abnormality of dentin (HP:0010299)1.46661761
158Aplasia/Hypoplasia involving the musculature (HP:0001460)1.46210899
159Abnormality of the umbilical cord (HP:0010881)1.42932568
160Aortic dissection (HP:0002647)1.42629296
161Biliary tract neoplasm (HP:0100574)1.42293066
162Absent frontal sinuses (HP:0002688)1.42273098
163Scapular winging (HP:0003691)1.40548827
164Abnormality of the shoulder girdle musculature (HP:0001435)1.39419833
165Maternal diabetes (HP:0009800)1.37439690
166Rocker bottom foot (HP:0001838)1.37211783
167Trismus (HP:0000211)1.36396140
168Breast carcinoma (HP:0003002)1.36343547
169Proximal amyotrophy (HP:0007126)1.35599142
170Syringomyelia (HP:0003396)1.34273457
171Spinal cord lesions (HP:0100561)1.34273457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.37744953
2ZAK4.37359367
3AKT33.72891689
4STK38L2.88296385
5SRPK12.57209767
6CDK122.54774926
7SIK32.34165337
8FRK2.32540103
9BUB12.28424038
10EPHA22.16339064
11PASK2.11947207
12TAF12.09048795
13ERBB32.07547721
14PRKD32.04994521
15CASK1.98041892
16EEF2K1.95513803
17MET1.89982632
18BCR1.88990615
19NEK11.88458453
20INSRR1.87475551
21MKNK21.84805082
22ERBB41.84336479
23MST1R1.79731375
24TTN1.78844009
25LATS11.78713639
26PHKG21.72332597
27PHKG11.72332597
28MAP3K121.68892697
29CDC71.66782302
30IRAK31.64306798
31SGK21.57677902
32PRPF4B1.52457107
33VRK21.52081323
34TTK1.48982083
35PLK31.47661589
36PBK1.46254635
37EIF2AK11.44857354
38TLK11.44003130
39BRD41.41422828
40SMG11.39993590
41PNCK1.35208784
42MAP3K21.31404525
43NEK91.31385678
44PRKG21.30319459
45YES11.28912208
46MKNK11.27467802
47EIF2AK21.18358435
48BRSK21.18004979
49CDK81.16868697
50CHEK21.15073567
51NUAK11.14773928
52NEK21.10903997
53OBSCN1.10338902
54TRPM71.07641401
55NME11.07015988
56BMPR1B1.06108113
57PTK21.05246908
58PLK11.05004499
59VRK11.03718465
60TRIM281.02649626
61NEK61.01899627
62ATR1.01041015
63ATM0.99172131
64PAK40.98457216
65PLK40.98148687
66CDK70.92471317
67EPHA30.90592490
68TNIK0.90011359
69PDGFRA0.89559642
70SGK2230.83225019
71SGK4940.83225019
72MAP3K140.83045236
73BRSK10.82768223
74AURKA0.81811660
75RPS6KB20.80930912
76TSSK60.80084919
77SGK30.80066093
78GRK10.79839537
79AURKB0.78968984
80MAP3K100.78731260
81MAPKAPK30.78540679
82FGFR10.77361476
83STK30.76876594
84STK240.76525011
85CAMK1G0.74652979
86STK160.73868378
87TAOK20.70556832
88LATS20.69961324
89MST40.69523356
90IRAK10.69432050
91EIF2AK30.65281190
92RPS6KB10.65190026
93SCYL20.64795074
94IRAK20.64358258
95STK390.63941254
96PDK20.63875400
97RPS6KA20.63445310
98FER0.62359977
99PRKCI0.61903488
100MELK0.61177141
101CHUK0.60241471
102ADRBK10.60120793
103LIMK10.59517277
104CHEK10.59407482
105BRAF0.57666972
106HIPK20.56829461
107MTOR0.54583357
108ADRBK20.53302650
109DYRK30.53141878
110CDC42BPA0.52730313
111PLK20.51787121
112PKN20.50836055
113BMPR20.50703197
114WEE10.50563362
115MUSK0.50251002
116CDK10.50140049
117CDK20.49430403
118RPS6KC10.48997415
119RPS6KL10.48997415
120ICK0.48326561
121CAMK1D0.48091096
122MAP3K30.47550616
123DDR20.47333941
124TRIB30.46282899
125WNK10.45708419
126NTRK10.43691774
127AKT10.43593955
128AKT20.42998085
129DMPK0.42786208
130FLT30.42638796
131IRAK40.41695172
132MAPK130.41627428
133ACVR1B0.41410920
134MAPK150.41214787
135CDK60.38605584
136CSNK2A10.37836114
137MAPK140.37791738
138PRKCE0.36895847
139ROCK10.36843562
140PRKDC0.36655696
141PAK20.34563023
142PIM10.34243749
143CDK90.33840756
144PIK3CG0.33810033
145MAP3K70.33513033
146MYLK0.33384742
147CSNK1G10.33155969
148EPHB20.32765077
149NLK0.32684136
150STK100.32179590
151STK380.29907401
152TGFBR10.29473981
153CSNK1E0.27833523

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034302.85534416
2Fanconi anemia pathway_Homo sapiens_hsa034602.84929813
3Protein export_Homo sapiens_hsa030602.58890724
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.49856639
5Cell cycle_Homo sapiens_hsa041102.46778306
6Homologous recombination_Homo sapiens_hsa034402.30530867
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28591899
8Non-homologous end-joining_Homo sapiens_hsa034502.23019670
9Nucleotide excision repair_Homo sapiens_hsa034202.12327174
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12043139
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.09933417
12DNA replication_Homo sapiens_hsa030302.03190730
13RNA transport_Homo sapiens_hsa030131.98751344
14Basal transcription factors_Homo sapiens_hsa030221.95736746
15Basal cell carcinoma_Homo sapiens_hsa052171.89269053
16RNA polymerase_Homo sapiens_hsa030201.86164622
17RNA degradation_Homo sapiens_hsa030181.80260568
18One carbon pool by folate_Homo sapiens_hsa006701.73958015
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.73401465
20mRNA surveillance pathway_Homo sapiens_hsa030151.66281498
21Hippo signaling pathway_Homo sapiens_hsa043901.65144809
22Thyroid cancer_Homo sapiens_hsa052161.57822338
23Base excision repair_Homo sapiens_hsa034101.57327636
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55447772
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53645031
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51984370
27Sulfur metabolism_Homo sapiens_hsa009201.46772002
28Systemic lupus erythematosus_Homo sapiens_hsa053221.46206141
29Adherens junction_Homo sapiens_hsa045201.44811651
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.44123074
31p53 signaling pathway_Homo sapiens_hsa041151.38052300
32Spliceosome_Homo sapiens_hsa030401.37230634
33Dilated cardiomyopathy_Homo sapiens_hsa054141.34895339
34Melanoma_Homo sapiens_hsa052181.32700314
35TGF-beta signaling pathway_Homo sapiens_hsa043501.31407003
36Pyruvate metabolism_Homo sapiens_hsa006201.27361507
37Hedgehog signaling pathway_Homo sapiens_hsa043401.25942253
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25146027
39Taste transduction_Homo sapiens_hsa047421.21975516
40Prostate cancer_Homo sapiens_hsa052151.20142260
41Endometrial cancer_Homo sapiens_hsa052131.14379181
42Biosynthesis of amino acids_Homo sapiens_hsa012301.09114837
43Pyrimidine metabolism_Homo sapiens_hsa002401.08261506
44Alcoholism_Homo sapiens_hsa050341.07972844
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04617234
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99690275
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99310721
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98569241
49MicroRNAs in cancer_Homo sapiens_hsa052060.98317964
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98038287
51Huntingtons disease_Homo sapiens_hsa050160.96308374
52Propanoate metabolism_Homo sapiens_hsa006400.95513265
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94894928
54Wnt signaling pathway_Homo sapiens_hsa043100.92249896
55* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90341087
56Viral carcinogenesis_Homo sapiens_hsa052030.89084530
57FoxO signaling pathway_Homo sapiens_hsa040680.88130049
58Proteasome_Homo sapiens_hsa030500.87663812
59Vibrio cholerae infection_Homo sapiens_hsa051100.87076344
60Purine metabolism_Homo sapiens_hsa002300.86552525
61Tight junction_Homo sapiens_hsa045300.84617571
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84193513
63Cardiac muscle contraction_Homo sapiens_hsa042600.82753028
64HTLV-I infection_Homo sapiens_hsa051660.80047515
65Glucagon signaling pathway_Homo sapiens_hsa049220.77791956
66Regulation of autophagy_Homo sapiens_hsa041400.77701677
67Carbon metabolism_Homo sapiens_hsa012000.74835574
68Epstein-Barr virus infection_Homo sapiens_hsa051690.74482215
69Pathways in cancer_Homo sapiens_hsa052000.73169947
70Galactose metabolism_Homo sapiens_hsa000520.71588355
71Prolactin signaling pathway_Homo sapiens_hsa049170.69431553
72Phenylalanine metabolism_Homo sapiens_hsa003600.68647856
73Glutathione metabolism_Homo sapiens_hsa004800.68533194
74Vitamin B6 metabolism_Homo sapiens_hsa007500.67894338
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67569989
76Colorectal cancer_Homo sapiens_hsa052100.67030699
77Arginine and proline metabolism_Homo sapiens_hsa003300.66848307
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66749112
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66202249
80Steroid biosynthesis_Homo sapiens_hsa001000.63186666
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61590694
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60692051
83Fructose and mannose metabolism_Homo sapiens_hsa000510.60221528
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60160874
85Circadian rhythm_Homo sapiens_hsa047100.58593276
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58357953
87Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57539402
88N-Glycan biosynthesis_Homo sapiens_hsa005100.55935998
89Bladder cancer_Homo sapiens_hsa052190.55444017
90Oocyte meiosis_Homo sapiens_hsa041140.54427495
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54302752
92mTOR signaling pathway_Homo sapiens_hsa041500.52856759
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52575438
94Proteoglycans in cancer_Homo sapiens_hsa052050.52060654
95beta-Alanine metabolism_Homo sapiens_hsa004100.51845441
96Pentose phosphate pathway_Homo sapiens_hsa000300.51228946
97Ribosome_Homo sapiens_hsa030100.51040229
98Axon guidance_Homo sapiens_hsa043600.50490964
99ECM-receptor interaction_Homo sapiens_hsa045120.50183658
100Arachidonic acid metabolism_Homo sapiens_hsa005900.50068558
101Herpes simplex infection_Homo sapiens_hsa051680.48196073
102Mineral absorption_Homo sapiens_hsa049780.47865309
103AMPK signaling pathway_Homo sapiens_hsa041520.47616285
104Fatty acid elongation_Homo sapiens_hsa000620.46375741
105Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45507892
106Tyrosine metabolism_Homo sapiens_hsa003500.45368002
107Insulin secretion_Homo sapiens_hsa049110.45366693
108Melanogenesis_Homo sapiens_hsa049160.45355012
109Type II diabetes mellitus_Homo sapiens_hsa049300.45348380
110Selenocompound metabolism_Homo sapiens_hsa004500.44722404
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44158937
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44099591
113Notch signaling pathway_Homo sapiens_hsa043300.43350119
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42815082
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42349952
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41615625
117Sphingolipid metabolism_Homo sapiens_hsa006000.39482058
118Folate biosynthesis_Homo sapiens_hsa007900.39149379
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38887211
120Focal adhesion_Homo sapiens_hsa045100.38721870
121Small cell lung cancer_Homo sapiens_hsa052220.38066727
122Insulin signaling pathway_Homo sapiens_hsa049100.37191204
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36953374
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36508145
125Protein digestion and absorption_Homo sapiens_hsa049740.34691891
126Legionellosis_Homo sapiens_hsa051340.34586856
127Nitrogen metabolism_Homo sapiens_hsa009100.34008399
128Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33140667
129Dorso-ventral axis formation_Homo sapiens_hsa043200.32291897
130Chronic myeloid leukemia_Homo sapiens_hsa052200.32130833
131Metabolic pathways_Homo sapiens_hsa011000.31977981
132Insulin resistance_Homo sapiens_hsa049310.31616150
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30720121
134Influenza A_Homo sapiens_hsa051640.29928429
135Phagosome_Homo sapiens_hsa041450.29246554
136Starch and sucrose metabolism_Homo sapiens_hsa005000.28341016
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28254536
138NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28005898
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27974568
140Inositol phosphate metabolism_Homo sapiens_hsa005620.27917698
141Lysine degradation_Homo sapiens_hsa003100.27750192
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.27603541

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