SIX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1planar cell polarity pathway involved in neural tube closure (GO:0090179)4.64712416
2regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.28367928
3G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.90367547
4exocrine pancreas development (GO:0031017)3.86372764
5atrioventricular valve morphogenesis (GO:0003181)3.73739472
6cell proliferation involved in metanephros development (GO:0072203)3.72339376
7anatomical structure regression (GO:0060033)3.67187361
8bone trabecula formation (GO:0060346)3.64983859
9heterochromatin organization (GO:0070828)3.57787315
10semaphorin-plexin signaling pathway (GO:0071526)3.57282815
11outer ear morphogenesis (GO:0042473)3.55899145
12paraxial mesoderm development (GO:0048339)3.52653253
13lateral sprouting from an epithelium (GO:0060601)3.49424525
14cardiac myofibril assembly (GO:0055003)3.48910918
15protein heterotrimerization (GO:0070208)3.40362515
16apoptotic process involved in morphogenesis (GO:0060561)3.38765928
17branching involved in salivary gland morphogenesis (GO:0060445)3.38686025
18polarized epithelial cell differentiation (GO:0030859)3.38489553
19ribosomal small subunit biogenesis (GO:0042274)3.33703018
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.33650862
21mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.33111196
22cell migration involved in heart development (GO:0060973)3.31944621
23Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.31868235
24adherens junction assembly (GO:0034333)3.28082916
25convergent extension (GO:0060026)3.27494415
26middle ear morphogenesis (GO:0042474)3.25431868
27cochlea morphogenesis (GO:0090103)3.23754851
28regulation of heart morphogenesis (GO:2000826)3.23544935
29non-canonical Wnt signaling pathway (GO:0035567)3.21232877
30mesenchymal cell differentiation involved in kidney development (GO:0072161)3.21108336
31mesenchymal cell differentiation involved in renal system development (GO:2001012)3.21108336
32mesenchyme morphogenesis (GO:0072132)3.20713561
33notochord development (GO:0030903)3.17473309
34endothelial cell morphogenesis (GO:0001886)3.16927403
35regulation of establishment of planar polarity (GO:0090175)3.15521337
36blood vessel maturation (GO:0001955)3.15165467
37establishment or maintenance of monopolar cell polarity (GO:0061339)3.12514741
38establishment of monopolar cell polarity (GO:0061162)3.12514741
39basement membrane organization (GO:0071711)3.11811719
40protein retention in ER lumen (GO:0006621)3.10056170
41Golgi transport vesicle coating (GO:0048200)3.07739774
42COPI coating of Golgi vesicle (GO:0048205)3.07739774
43embryonic skeletal joint morphogenesis (GO:0060272)3.06602294
44maternal placenta development (GO:0001893)3.05121531
45cell-substrate adherens junction assembly (GO:0007045)3.03710726
46focal adhesion assembly (GO:0048041)3.03710726
47establishment of apical/basal cell polarity (GO:0035089)3.03649606
48negative regulation of cell size (GO:0045792)3.01858954
49apoptotic process involved in development (GO:1902742)3.01746760
50cell-cell junction maintenance (GO:0045217)3.01290829
51glomerular basement membrane development (GO:0032836)3.00916220
52proline biosynthetic process (GO:0006561)2.98826978
53metanephric mesenchyme development (GO:0072075)2.98463328
54respiratory tube development (GO:0030323)2.98006060
55hippo signaling (GO:0035329)2.97897279
56trabecula formation (GO:0060343)2.97153329
57axon extension involved in axon guidance (GO:0048846)2.94472193
58neuron projection extension involved in neuron projection guidance (GO:1902284)2.94472193
59endocardial cushion morphogenesis (GO:0003203)2.94406976
60negative regulation of chondrocyte differentiation (GO:0032331)2.94402188
61regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94360094
62glandular epithelial cell development (GO:0002068)2.92744755
63mesenchymal cell proliferation (GO:0010463)2.90463860
64regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.89748611
65vascular endothelial growth factor signaling pathway (GO:0038084)2.89653622
66regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.89256134
67glomerular filtration (GO:0003094)2.88876547
68camera-type eye morphogenesis (GO:0048593)2.87461550
69proximal/distal pattern formation (GO:0009954)2.87056958
70negative regulation of cartilage development (GO:0061037)2.86528192
71endothelial cell chemotaxis (GO:0035767)2.84443910
72kidney mesenchyme development (GO:0072074)2.83857048
73cell proliferation involved in kidney development (GO:0072111)2.82718364
74regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.82663030
75insulin-like growth factor receptor signaling pathway (GO:0048009)2.81555952
76desmosome organization (GO:0002934)2.81528962
77regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.80711200
78heart trabecula formation (GO:0060347)2.80411386
79collagen fibril organization (GO:0030199)2.79250459
80pattern specification involved in kidney development (GO:0061004)2.78364319
81head development (GO:0060322)2.78224400
82negative regulation of embryonic development (GO:0045992)2.76505693
83L-serine metabolic process (GO:0006563)2.76053809
84neural tube development (GO:0021915)2.73188114
85outflow tract septum morphogenesis (GO:0003148)2.72363364
86type B pancreatic cell development (GO:0003323)2.69526428
87lung epithelium development (GO:0060428)2.69130242
88definitive hemopoiesis (GO:0060216)2.68840157
89renal filtration (GO:0097205)2.67732720
90establishment or maintenance of apical/basal cell polarity (GO:0035088)2.67315868
91establishment or maintenance of bipolar cell polarity (GO:0061245)2.67315868
92positive regulation of mesenchymal cell proliferation (GO:0002053)2.67153047
93establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.66321220
94cell-substrate junction assembly (GO:0007044)2.65760618
95establishment of planar polarity (GO:0001736)2.64646097
96establishment of tissue polarity (GO:0007164)2.64646097
97organ formation (GO:0048645)2.64487629
98UV protection (GO:0009650)2.63708685
99embryonic camera-type eye morphogenesis (GO:0048596)2.62395131
100mitotic chromosome condensation (GO:0007076)2.61097495
101negative regulation of catenin import into nucleus (GO:0035414)2.59935505
102body morphogenesis (GO:0010171)2.59899446
103heart morphogenesis (GO:0003007)2.59081465
104positive regulation of glycogen biosynthetic process (GO:0045725)2.58714739
105regulation of translational fidelity (GO:0006450)2.58307809
106craniofacial suture morphogenesis (GO:0097094)2.57683206
107regulation of glucose import in response to insulin stimulus (GO:2001273)2.57494635
108myofibril assembly (GO:0030239)2.57427662
109cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.57217393
110negative regulation of fatty acid transport (GO:2000192)2.56713492
111positive regulation of gastrulation (GO:2000543)2.56547028
112cardiac muscle cell proliferation (GO:0060038)2.56166167
113viral transcription (GO:0019083)2.56071997
114mesenchyme development (GO:0060485)2.55941573
115epithelial cell-cell adhesion (GO:0090136)2.55398100
116renal system development (GO:0072001)2.54873448
117hindlimb morphogenesis (GO:0035137)2.54826587
118protein carboxylation (GO:0018214)2.54485677
119peptidyl-glutamic acid carboxylation (GO:0017187)2.54485677
120endocardial cushion development (GO:0003197)2.54189039
121positive regulation of cartilage development (GO:0061036)2.53718997
122regulation of cardioblast differentiation (GO:0051890)2.52922812
123mesonephros development (GO:0001823)2.52625903
124lung vasculature development (GO:0060426)2.52009300
125mesenchymal-epithelial cell signaling (GO:0060638)2.51283121
126radial glial cell differentiation (GO:0060019)2.51117691
127muscle cell migration (GO:0014812)2.50967297
128mesenchymal to epithelial transition (GO:0060231)2.50940119
129positive regulation of hormone biosynthetic process (GO:0046886)2.50558565
130negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.50319555
131lymph vessel development (GO:0001945)2.49826299
132embryonic hindlimb morphogenesis (GO:0035116)2.49482112
133dorsal/ventral axis specification (GO:0009950)2.49358597
134eye morphogenesis (GO:0048592)2.48818791
135skin morphogenesis (GO:0043589)2.48294278
136positive regulation of epithelial to mesenchymal transition (GO:0010718)2.47749650
137regulation of mesenchymal cell proliferation (GO:0010464)2.47322236
138negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.46000432
139translational termination (GO:0006415)2.45941157
140embryonic cranial skeleton morphogenesis (GO:0048701)2.45612056
141embryonic foregut morphogenesis (GO:0048617)2.45454853
142regulation of organ formation (GO:0003156)2.44866939
143positive regulation of smoothened signaling pathway (GO:0045880)2.42307887
144dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.41249063
145tooth mineralization (GO:0034505)2.39069020
146negative regulation of cell fate specification (GO:0009996)2.37846448
147embryonic camera-type eye development (GO:0031076)2.37231399
148growth hormone secretion (GO:0030252)2.34729914
149activation of Rac GTPase activity (GO:0032863)2.32579369
150retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.32149693
151cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.31974640
152hemidesmosome assembly (GO:0031581)2.31832505
153proline metabolic process (GO:0006560)2.29319512
154white fat cell differentiation (GO:0050872)2.25367382
155cell migration involved in sprouting angiogenesis (GO:0002042)2.24713405
156gap junction assembly (GO:0016264)2.23990545
157regulation of early endosome to late endosome transport (GO:2000641)2.23045842
158vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.22058939
159regulation of catenin import into nucleus (GO:0035412)2.21873862
160nucleosome disassembly (GO:0006337)2.21271043
161protein-DNA complex disassembly (GO:0032986)2.21271043

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.99626060
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.93251557
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.76260474
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.54574094
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87852070
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.75647335
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.72958929
8E2F7_22180533_ChIP-Seq_HELA_Human2.68435907
9CLOCK_20551151_ChIP-Seq_293T_Human2.55702629
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.53773067
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40820933
12EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.39383622
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12853566
14* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.09155453
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.02375320
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.01654390
17* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.99597177
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98634775
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.97982966
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.90942444
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90144116
22MYC_22102868_ChIP-Seq_BL_Human1.89883542
23* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.89259725
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82505420
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79014109
26MYC_18555785_ChIP-Seq_MESCs_Mouse1.79005214
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78340933
28* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.78026948
29* KDM2B_26808549_Chip-Seq_K562_Human1.77638650
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.76716562
31P68_20966046_ChIP-Seq_HELA_Human1.75999655
32LXR_22292898_ChIP-Seq_THP-1_Human1.72673224
33TP53_20018659_ChIP-ChIP_R1E_Mouse1.72636822
34DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72399259
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.69305156
36NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.69175727
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.68100404
38* VDR_21846776_ChIP-Seq_THP-1_Human1.67919714
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.67509764
40* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65834711
41GATA1_22025678_ChIP-Seq_K562_Human1.64094002
42TBX20_22080862_ChIP-Seq_HEART_Mouse1.63970816
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.63970816
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63926892
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56910393
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.56770126
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56487971
48* RACK7_27058665_Chip-Seq_MCF-7_Human1.55815123
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.55529514
50CTCF_27219007_Chip-Seq_Bcells_Human1.53629857
51* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52442333
52SMC4_20622854_ChIP-Seq_HELA_Human1.51466267
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51451371
54ZNF263_19887448_ChIP-Seq_K562_Human1.50954372
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50694624
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.49262988
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48978348
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.47858096
59TP53_22127205_ChIP-Seq_IMR90_Human1.47178977
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.47177198
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.47015223
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.46709868
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45603717
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.45588568
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44738204
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44138922
67CIITA_25753668_ChIP-Seq_RAJI_Human1.44125713
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42263624
69TCF7_22412390_ChIP-Seq_EML_Mouse1.40583916
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40500778
71HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38952858
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38301880
73MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.37415583
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36325082
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32751141
76UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31330632
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30575039
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30292628
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30259815
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29846460
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27887582
82* KDM2B_26808549_Chip-Seq_DND41_Human1.27589552
83GATA4_21415370_ChIP-Seq_HL-1_Mouse1.27225076
84RXR_22158963_ChIP-Seq_LIVER_Mouse1.25965781
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24961950
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24273423
87MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.24214815
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.23965851
89ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23535873
90* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23283202
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.22017191
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21971491
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.19414337
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18962454
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.18945932
96STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18688693
97ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18381465
98* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17717837
99ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16811445
100ATF3_27146783_Chip-Seq_COLON_Human1.16597641
101* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15084930
102CHD1_26751641_Chip-Seq_LNCaP_Human1.14805641
103AR_21909140_ChIP-Seq_LNCAP_Human1.14599039
104FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.14387669
105* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12986509
106LXR_22158963_ChIP-Seq_LIVER_Mouse1.12693568
107SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12612175
108* UBF1/2_26484160_Chip-Seq_HMECs_Human1.11202965
109SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11196603
110BRD4_25478319_ChIP-Seq_HGPS_Human1.10480648
111NCOR1_26117541_ChIP-Seq_K562_Human1.09812079
112* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09714605
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09535285
114ELF1_20517297_ChIP-Seq_JURKAT_Human1.09138002
115FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.09108357
116STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.08961823
117SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08601893
118KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07429015
119* FOXP1_21924763_ChIP-Seq_HESCs_Human1.06896143
120E2F1_21310950_ChIP-Seq_MCF-7_Human1.06078414
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05853972
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05799928
123* RARA_24833708_ChIP-Seq_LIVER_Mouse1.05380778
124TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05346327
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05287912
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04533025
127STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02792007
128* RARB_24833708_ChIP-Seq_LIVER_Mouse1.02731111
129NANOG_21062744_ChIP-ChIP_HESCs_Human1.01093420
130* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00565283
131CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00238913
132MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00120512
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99876895
134KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98785439
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98361290
136* TP63_22573176_ChIP-Seq_HFKS_Human0.98324802
137SCL_19346495_ChIP-Seq_HPC-7_Human0.97845902
138MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97821482
139* CREB1_26743006_Chip-Seq_LNCaP_Human0.97661320
140NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95990028
141RUNX1_27514584_Chip-Seq_MCF-7_Human0.89824742
142XRN2_22483619_ChIP-Seq_HELA_Human0.89807230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.62941080
2MP0005503_abnormal_tendon_morphology3.08105713
3MP0010030_abnormal_orbit_morphology2.98820690
4MP0003705_abnormal_hypodermis_morpholog2.86297266
5MP0004272_abnormal_basement_membrane2.65774499
6MP0006054_spinal_hemorrhage2.55727657
7MP0005257_abnormal_intraocular_pressure2.52751803
8MP0001849_ear_inflammation2.51576587
9MP0002249_abnormal_larynx_morphology2.20479099
10MP0009053_abnormal_anal_canal2.10964316
11MP0005275_abnormal_skin_tensile2.09577349
12MP0002938_white_spotting2.07427878
13MP0004858_abnormal_nervous_system2.06427699
14MP0009379_abnormal_foot_pigmentation2.05694962
15MP0003385_abnormal_body_wall1.99212343
16MP0000049_abnormal_middle_ear1.96811829
17MP0003942_abnormal_urinary_system1.92524009
18MP0003279_aneurysm1.91624085
19MP0009250_abnormal_appendicular_skeleto1.86726925
20MP0003283_abnormal_digestive_organ1.85687959
21MP0010368_abnormal_lymphatic_system1.84693815
22MP0006292_abnormal_olfactory_placode1.83878553
23MP0003122_maternal_imprinting1.75803989
24MP0005508_abnormal_skeleton_morphology1.72679200
25MP0000537_abnormal_urethra_morphology1.70677492
26MP0005409_darkened_coat_color1.68735718
27MP0000428_abnormal_craniofacial_morphol1.64623103
28MP0003567_abnormal_fetal_cardiomyocyte1.64280782
29MP0000534_abnormal_ureter_morphology1.61185398
30MP0002837_dystrophic_cardiac_calcinosis1.59731183
31MP0001879_abnormal_lymphatic_vessel1.58690454
32MP0004084_abnormal_cardiac_muscle1.58284425
33MP0002932_abnormal_joint_morphology1.55348968
34MP0003115_abnormal_respiratory_system1.53389901
35MP0000678_abnormal_parathyroid_gland1.52242583
36MP0006138_congestive_heart_failure1.43522785
37MP0003935_abnormal_craniofacial_develop1.42758813
38MP0009384_cardiac_valve_regurgitation1.42340620
39MP0002282_abnormal_trachea_morphology1.41274311
40MP0010630_abnormal_cardiac_muscle1.38801459
41MP0001299_abnormal_eye_distance/1.37485750
42MP0005367_renal/urinary_system_phenotyp1.34602329
43MP0000516_abnormal_urinary_system1.34602329
44MP0001348_abnormal_lacrimal_gland1.34348616
45MP0000762_abnormal_tongue_morphology1.33796156
46MP0002089_abnormal_postnatal_growth/wei1.31835241
47MP0003937_abnormal_limbs/digits/tail_de1.31530691
48MP0001293_anophthalmia1.31262506
49MP0000751_myopathy1.31064519
50MP0000566_synostosis1.28178985
51MP0000767_abnormal_smooth_muscle1.27660389
52MP0003566_abnormal_cell_adhesion1.25250028
53MP0002877_abnormal_melanocyte_morpholog1.25209174
54MP0005623_abnormal_meninges_morphology1.24754069
55MP0003828_pulmonary_edema1.24351254
56MP0005058_abnormal_lysosome_morphology1.22128484
57MP0004185_abnormal_adipocyte_glucose1.21715528
58MP0005501_abnormal_skin_physiology1.20651391
59MP0002060_abnormal_skin_morphology1.19775167
60MP0000163_abnormal_cartilage_morphology1.18094575
61MP0005377_hearing/vestibular/ear_phenot1.17632088
62MP0003878_abnormal_ear_physiology1.17632088
63MP0005330_cardiomyopathy1.16534496
64MP0003119_abnormal_digestive_system1.16275714
65MP0002108_abnormal_muscle_morphology1.13937122
66MP0005187_abnormal_penis_morphology1.13706988
67MP0000579_abnormal_nail_morphology1.13486657
68MP0005220_abnormal_exocrine_pancreas1.13467555
69MP0001270_distended_abdomen1.13009794
70MP0003941_abnormal_skin_development1.12958327
71MP0003755_abnormal_palate_morphology1.12793748
72MP0008789_abnormal_olfactory_epithelium1.12462384
73MP0000467_abnormal_esophagus_morphology1.12058970
74MP0002116_abnormal_craniofacial_bone1.09116811
75MP0003453_abnormal_keratinocyte_physiol1.08266522
76MP0000733_abnormal_muscle_development1.07259331
77MP0002254_reproductive_system_inflammat1.07022448
78MP0001958_emphysema1.05299473
79MP0003123_paternal_imprinting1.04173383
80MP0000266_abnormal_heart_morphology1.03098185
81MP0002109_abnormal_limb_morphology1.03055656
82MP0002796_impaired_skin_barrier1.02919739
83MP0005248_abnormal_Harderian_gland1.01876048
84MP0004087_abnormal_muscle_fiber1.01836221
85MP0002896_abnormal_bone_mineralization1.01315054
86MP0010352_gastrointestinal_tract_polyps1.00672640
87MP0002115_abnormal_skeleton_extremities1.00394431
88MP0005499_abnormal_olfactory_system0.99943198
89MP0005394_taste/olfaction_phenotype0.99943198
90MP0003136_yellow_coat_color0.99478747
91MP0002925_abnormal_cardiovascular_devel0.99452862
92MP0002128_abnormal_blood_circulation0.96790705
93MP0000759_abnormal_skeletal_muscle0.96222227
94MP0005385_cardiovascular_system_phenoty0.96120053
95MP0001544_abnormal_cardiovascular_syste0.96120053
96MP0002111_abnormal_tail_morphology0.96036625
97MP0000750_abnormal_muscle_regeneration0.95862829
98MP0000432_abnormal_head_morphology0.95592846
99MP0001661_extended_life_span0.95579037
100MP0009672_abnormal_birth_weight0.95303574
101MP0000613_abnormal_salivary_gland0.95151516
102MP0002127_abnormal_cardiovascular_syste0.95094406
103MP0005670_abnormal_white_adipose0.94441294
104MP0000003_abnormal_adipose_tissue0.94138982
105MP0000462_abnormal_digestive_system0.92711683
106MP0009278_abnormal_bone_marrow0.92384046
107MP0003938_abnormal_ear_development0.91331045
108MP0002233_abnormal_nose_morphology0.89321565
109MP0002092_abnormal_eye_morphology0.89223676
110MP0010234_abnormal_vibrissa_follicle0.88606758
111MP0004197_abnormal_fetal_growth/weight/0.88445856
112MP0002653_abnormal_ependyma_morphology0.87901414
113MP0008775_abnormal_heart_ventricle0.87431967
114MP0005023_abnormal_wound_healing0.84139802
115MP0002085_abnormal_embryonic_tissue0.83524691
116MP0005666_abnormal_adipose_tissue0.83462573
117MP0004036_abnormal_muscle_relaxation0.82817618
118MP0001614_abnormal_blood_vessel0.82706309
119MP0005076_abnormal_cell_differentiation0.82121226
120MP0003091_abnormal_cell_migration0.81419924
121MP0002234_abnormal_pharynx_morphology0.81415728
122MP0004233_abnormal_muscle_weight0.81131574
123MP0004215_abnormal_myocardial_fiber0.80911406
124MP0002113_abnormal_skeleton_development0.80562826
125MP0002697_abnormal_eye_size0.80232873
126MP0000013_abnormal_adipose_tissue0.80009795
127MP0002114_abnormal_axial_skeleton0.79779290
128MP0002972_abnormal_cardiac_muscle0.79513541
129MP0005375_adipose_tissue_phenotype0.78634763
130MP0002084_abnormal_developmental_patter0.78268425
131MP0004264_abnormal_extraembryonic_tissu0.78199485
132MP0001340_abnormal_eyelid_morphology0.77461782
133MP0001286_abnormal_eye_development0.76894326
134MP0000747_muscle_weakness0.76694890

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.56614305
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.36063272
3Short 4th metacarpal (HP:0010044)4.36063272
4Broad metatarsal (HP:0001783)3.95016499
5Ankle contracture (HP:0006466)3.86159248
6Abnormality of the 4th metacarpal (HP:0010012)3.82568496
7Premature rupture of membranes (HP:0001788)3.76615951
8Shallow orbits (HP:0000586)3.46958917
9Aortic dissection (HP:0002647)3.03205909
10Bladder diverticulum (HP:0000015)2.89851085
11Cerebral aneurysm (HP:0004944)2.87941557
12Renal duplication (HP:0000075)2.86758499
13Broad toe (HP:0001837)2.72320713
14Obstructive sleep apnea (HP:0002870)2.71406506
15Soft skin (HP:0000977)2.70160755
16Thin ribs (HP:0000883)2.61415202
17Abnormality of the parietal bone (HP:0002696)2.58807877
18Atrophic scars (HP:0001075)2.51518472
19Lymphangioma (HP:0100764)2.48510161
20Aortic aneurysm (HP:0004942)2.48162709
21Turricephaly (HP:0000262)2.39000780
22Type 1 muscle fiber predominance (HP:0003803)2.38823824
23Broad hallux (HP:0010055)2.38218877
24Vertebral compression fractures (HP:0002953)2.34626683
25Disproportionate tall stature (HP:0001519)2.33274038
26Coronal craniosynostosis (HP:0004440)2.28230614
27Pterygium (HP:0001059)2.28060348
28Midline defect of the nose (HP:0004122)2.27893456
29Follicular hyperkeratosis (HP:0007502)2.26732560
30Thin bony cortex (HP:0002753)2.25770920
31Upper limb amyotrophy (HP:0009129)2.25518772
32Distal upper limb amyotrophy (HP:0007149)2.25518772
33Mildly elevated creatine phosphokinase (HP:0008180)2.23485250
34Abnormality of the calcaneus (HP:0008364)2.21930627
35Stridor (HP:0010307)2.20918499
36Wide anterior fontanel (HP:0000260)2.17861505
37Asymmetry of the thorax (HP:0001555)2.17526860
38Increased connective tissue (HP:0009025)2.17222769
39Genu recurvatum (HP:0002816)2.14937449
40Long palpebral fissure (HP:0000637)2.14535100
41Metaphyseal cupping (HP:0003021)2.14278271
42Broad thumb (HP:0011304)2.13725993
43Blue sclerae (HP:0000592)2.12566782
44Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.12477924
45Absent epiphyses (HP:0010577)2.12477924
46Lipoatrophy (HP:0100578)2.12147120
47Vitreoretinal degeneration (HP:0000655)2.10993518
48Sudden death (HP:0001699)2.10529894
49Partial duplication of thumb phalanx (HP:0009944)2.09901961
50Fragile skin (HP:0001030)2.09894185
51Selective tooth agenesis (HP:0001592)2.09440389
52Neonatal short-limb short stature (HP:0008921)2.09438231
53Round ear (HP:0100830)2.09346439
54Mesomelia (HP:0003027)2.07807271
55Cervical subluxation (HP:0003308)2.06250705
56Hypoglycemic coma (HP:0001325)2.06006253
57Mitral valve prolapse (HP:0001634)2.05709505
58Spinal rigidity (HP:0003306)2.05388630
59Aneurysm (HP:0002617)2.05187458
60Camptodactyly of toe (HP:0001836)2.04195312
61Short middle phalanx of the 5th finger (HP:0004220)2.02978528
62Abnormality of dentin (HP:0010299)2.02529994
63Right ventricular cardiomyopathy (HP:0011663)2.02469750
64Flattened epiphyses (HP:0003071)2.01826403
65Abnormality of the aortic arch (HP:0012303)2.01249346
66Mesangial abnormality (HP:0001966)2.00917224
67Morphological abnormality of the middle ear (HP:0008609)2.00656658
68Increased variability in muscle fiber diameter (HP:0003557)2.00230138
69Deviation of the hallux (HP:0010051)1.98624668
70Ventricular tachycardia (HP:0004756)1.97880184
71Subaortic stenosis (HP:0001682)1.95680456
72Abnormality of the left ventricular outflow tract (HP:0011103)1.95680456
73Ulnar bowing (HP:0003031)1.93961677
74High anterior hairline (HP:0009890)1.93762572
75Rib fusion (HP:0000902)1.93058487
76Atelectasis (HP:0100750)1.91783725
77Advanced eruption of teeth (HP:0006288)1.91128013
78J-shaped sella turcica (HP:0002680)1.90915798
79Abnormality of the distal phalanges of the toes (HP:0010182)1.89976480
80Vascular tortuosity (HP:0004948)1.89691817
81Broad long bones (HP:0005622)1.88863654
82Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88559335
83Short 5th finger (HP:0009237)1.87049375
84Long toe (HP:0010511)1.86854092
85Joint stiffness (HP:0001387)1.85974158
86Hallux valgus (HP:0001822)1.85138937
87Rectal prolapse (HP:0002035)1.84668070
88Flat acetabular roof (HP:0003180)1.84220694
89Shawl scrotum (HP:0000049)1.83779613
90Neoplasm of the heart (HP:0100544)1.83424395
91Ectopia lentis (HP:0001083)1.82175805
92Aortic regurgitation (HP:0001659)1.81714479
93Long eyelashes (HP:0000527)1.81220438
94Abnormality of the distal phalanx of the thumb (HP:0009617)1.80759745
95Pancreatic islet-cell hyperplasia (HP:0004510)1.80521649
96Abnormality of the thoracic spine (HP:0100711)1.80448460
97Short nail (HP:0001799)1.79779905
98Down-sloping shoulders (HP:0200021)1.79685059
99Bowed forearm bones (HP:0003956)1.79280783
100Bowing of the arm (HP:0006488)1.79280783
101Achilles tendon contracture (HP:0001771)1.79277217
102Abnormality of the acetabulum (HP:0003170)1.79044684
103Broad phalanges of the hand (HP:0009768)1.78727674
104Hypoplastic labia majora (HP:0000059)1.78085813
105Distal lower limb muscle weakness (HP:0009053)1.78032050
106Broad phalanx (HP:0006009)1.76490332
107Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.76243378
108Aplasia involving bones of the extremities (HP:0009825)1.75600080
109Aplasia involving bones of the upper limbs (HP:0009823)1.75600080
110Aplasia of the phalanges of the hand (HP:0009802)1.75600080
111Arterial tortuosity (HP:0005116)1.75472184
112Abnormal vertebral ossification (HP:0100569)1.75356706
113Arnold-Chiari malformation (HP:0002308)1.75023768
114Premature skin wrinkling (HP:0100678)1.74748510
115Elbow flexion contracture (HP:0002987)1.73928984
116Broad finger (HP:0001500)1.73179270
117Flexion contracture of toe (HP:0005830)1.72611500
118Joint contractures involving the joints of the feet (HP:0100492)1.72611500
119Hand muscle atrophy (HP:0009130)1.72553720
120Broad face (HP:0000283)1.71403949
121Abnormality of the phalanges of the hallux (HP:0010057)1.70072423
122Vertebral clefting (HP:0008428)1.69930391
123Abnormality of the nasolacrimal system (HP:0000614)1.69839745
124Bronchomalacia (HP:0002780)1.69811877
125Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69265742
126Abnormality of the 2nd finger (HP:0004100)1.69039524
127Hyperacusis (HP:0010780)1.68672104
128Hyperextensible skin (HP:0000974)1.67708622
129Distal lower limb amyotrophy (HP:0008944)1.67568077
130Generalized amyotrophy (HP:0003700)1.67412192
131Testicular atrophy (HP:0000029)1.67321078
132Natal tooth (HP:0000695)1.66849691
133Easy fatigability (HP:0003388)1.66817207
134Missing ribs (HP:0000921)1.66496234
135Wormian bones (HP:0002645)1.66086888
136Patent foramen ovale (HP:0001655)1.66042885
137Dilatation of the ascending aorta (HP:0005111)1.65647825
138Venous insufficiency (HP:0005293)1.65563351
139Enlarged penis (HP:0000040)1.64076193
140Supernumerary ribs (HP:0005815)1.62354796
141Joint laxity (HP:0001388)1.61989318
142Tarsal synostosis (HP:0008368)1.61949765
143Renovascular hypertension (HP:0100817)1.61782436
144Buphthalmos (HP:0000557)1.61085142
145Exostoses (HP:0100777)1.60787537
146Abnormality of the labia majora (HP:0012881)1.59957874
147Mitral regurgitation (HP:0001653)1.59110685
148Wide cranial sutures (HP:0010537)1.59042711
149Preaxial foot polydactyly (HP:0001841)1.58548838
150Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.58295884
151Bell-shaped thorax (HP:0001591)1.58061477
152Bowel diverticulosis (HP:0005222)1.57205062
153Carpal synostosis (HP:0009702)1.57071122
154Biconcave vertebral bodies (HP:0004586)1.56695574
155Sprengel anomaly (HP:0000912)1.56278178
156Partial duplication of the phalanx of hand (HP:0009999)1.55523732
157Short phalanx of the thumb (HP:0009660)1.55045641

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.14509710
2EPHA23.30369047
3SMG13.09958862
4LATS13.07170289
5TTN2.87671935
6PKN22.74112951
7SIK12.70439691
8PDGFRA2.41408718
9MAP3K102.38564699
10ERN12.33581356
11DDR22.24768701
12EPHB22.16928597
13MYLK2.11520072
14TIE12.00593092
15PTK62.00076130
16DMPK1.98781908
17BCKDK1.92164240
18MST1R1.88372637
19TGFBR11.87291933
20FLT31.84839845
21EPHA31.84222731
22EEF2K1.79776629
23RIPK11.74440588
24PASK1.71948484
25ICK1.57234786
26INSRR1.50203498
27IRAK31.46985982
28NTRK11.40364363
29MARK21.30727540
30PAK21.27404241
31MAPK151.27305117
32TESK11.24156010
33PRKD21.24050629
34MAP3K61.21089128
35TGFBR21.18909414
36PAK41.16015051
37ILK1.15329692
38MAP3K111.14995603
39CDK71.12576322
40MKNK11.11182875
41BRAF1.11095703
42MTOR1.09694960
43TYRO31.04799684
44MAPKAPK31.04501613
45TLK11.04062535
46STK38L1.02480555
47PRKD31.01949370
48LRRK21.01669328
49STK31.00846853
50PTK20.99284525
51LATS20.98298052
52LMTK20.97548373
53RPS6KA40.97191477
54CDC42BPA0.96808843
55RPS6KB20.95781733
56MUSK0.94306236
57DYRK1B0.93966645
58MAP2K30.92025156
59CAMK1D0.91901308
60MKNK20.86344603
61HIPK20.85126482
62ACVR1B0.84466053
63CAMK1G0.82974532
64AURKA0.82738583
65DYRK30.81582272
66ARAF0.81452270
67PIK3CA0.81202010
68CDK120.78874708
69MAP3K70.78052597
70FGFR10.77529858
71FER0.74885644
72PHKG10.74511211
73PHKG20.74511211
74KDR0.73886274
75PRKD10.73470886
76CDK60.71341068
77NME10.69959209
78VRK20.68694908
79EPHB10.65305909
80MET0.64271164
81PDGFRB0.62625113
82AKT20.62441049
83NEK20.60934764
84BRSK20.60632617
85PRPF4B0.60482171
86MAP2K20.59579377
87TTK0.59335799
88MAP3K30.58623868
89CDK40.58349472
90FGFR20.58155535
91RPS6KL10.57906225
92RPS6KC10.57906225
93SRPK10.56270025
94NME20.55962868
95CDK80.55783239
96ROCK10.55741791
97FGFR40.54837307
98MAP3K80.54484658
99MAPK110.53087548
100ERBB20.53059915
101RPS6KA60.52132069
102WEE10.52044677
103GSK3A0.51707269
104STK240.51698519
105FRK0.51681159
106DAPK30.49364487
107CHEK20.47581047
108PRKAA20.46891987
109TAOK20.45831902
110WNK40.45201862
111CDC70.45053424
112NEK90.44398783
113RPS6KA10.43951889
114BTK0.42294638
115BMX0.42267954
116PRKG20.42224727
117CAMK40.41824721
118MAP3K90.38418455
119WNK10.37937794
120KIT0.37904572
121PAK10.37891051
122PDPK10.37196848
123CDK90.37135253
124AURKB0.36877267
125MATK0.35495813
126PRKAA10.35474268
127MAPK10.34961145
128RPS6KA20.34583052
129PAK30.34541013
130AKT10.33988721
131ABL20.33161196
132PRKCI0.32742597
133CHEK10.32517385
134AKT30.32427258
135LIMK10.31663138
136STK40.30696566
137CDK11A0.30361280
138IRAK20.28562795
139PIM20.28306941
140CDK150.26199468

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.51668001
2Hedgehog signaling pathway_Homo sapiens_hsa043402.87528001
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.54101480
4ECM-receptor interaction_Homo sapiens_hsa045122.37821741
5Lysine degradation_Homo sapiens_hsa003102.03974512
6Hippo signaling pathway_Homo sapiens_hsa043901.97048442
7Protein digestion and absorption_Homo sapiens_hsa049741.93815900
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90558705
9Ribosome_Homo sapiens_hsa030101.88529075
10Focal adhesion_Homo sapiens_hsa045101.85783083
11Fatty acid degradation_Homo sapiens_hsa000711.83771500
12Notch signaling pathway_Homo sapiens_hsa043301.83235927
13Proteoglycans in cancer_Homo sapiens_hsa052051.63918328
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.63712013
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.62048263
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59949905
17Small cell lung cancer_Homo sapiens_hsa052221.59456708
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58750876
19Propanoate metabolism_Homo sapiens_hsa006401.58575768
20Dilated cardiomyopathy_Homo sapiens_hsa054141.56998061
21Adherens junction_Homo sapiens_hsa045201.55591972
22Phenylalanine metabolism_Homo sapiens_hsa003601.53976600
23TGF-beta signaling pathway_Homo sapiens_hsa043501.52822204
24Pentose phosphate pathway_Homo sapiens_hsa000301.50578082
25Protein export_Homo sapiens_hsa030601.48771059
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45766944
27Arginine biosynthesis_Homo sapiens_hsa002201.44827750
28Bladder cancer_Homo sapiens_hsa052191.42818905
29Cyanoamino acid metabolism_Homo sapiens_hsa004601.40922000
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39342861
31N-Glycan biosynthesis_Homo sapiens_hsa005101.34482950
32Fatty acid metabolism_Homo sapiens_hsa012121.34380603
33One carbon pool by folate_Homo sapiens_hsa006701.32651454
34DNA replication_Homo sapiens_hsa030301.31251728
35Fructose and mannose metabolism_Homo sapiens_hsa000511.30065720
36Wnt signaling pathway_Homo sapiens_hsa043101.29807368
37Base excision repair_Homo sapiens_hsa034101.26289808
38Other glycan degradation_Homo sapiens_hsa005111.24767203
39Insulin resistance_Homo sapiens_hsa049311.21681063
40Axon guidance_Homo sapiens_hsa043601.16914317
41Thyroid cancer_Homo sapiens_hsa052161.15372938
42MicroRNAs in cancer_Homo sapiens_hsa052061.13772210
43Sulfur relay system_Homo sapiens_hsa041221.13063122
44Spliceosome_Homo sapiens_hsa030401.12871973
45Viral myocarditis_Homo sapiens_hsa054161.12100034
46PI3K-Akt signaling pathway_Homo sapiens_hsa041511.05672979
47Pathways in cancer_Homo sapiens_hsa052001.03949665
48Cell cycle_Homo sapiens_hsa041101.03526993
49Melanogenesis_Homo sapiens_hsa049161.03239277
50HTLV-I infection_Homo sapiens_hsa051661.01990999
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.98021548
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97770990
53Chronic myeloid leukemia_Homo sapiens_hsa052200.96263398
54Prion diseases_Homo sapiens_hsa050200.95722846
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95720068
56Selenocompound metabolism_Homo sapiens_hsa004500.95262771
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95019042
58Mismatch repair_Homo sapiens_hsa034300.94305277
59Prostate cancer_Homo sapiens_hsa052150.93560051
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89505950
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88339983
62Amoebiasis_Homo sapiens_hsa051460.87029880
63Tryptophan metabolism_Homo sapiens_hsa003800.85837840
64VEGF signaling pathway_Homo sapiens_hsa043700.85090026
65AMPK signaling pathway_Homo sapiens_hsa041520.84850343
66PPAR signaling pathway_Homo sapiens_hsa033200.84735108
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84643378
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.82463320
69Carbon metabolism_Homo sapiens_hsa012000.82107622
70Tyrosine metabolism_Homo sapiens_hsa003500.81988051
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81865160
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76543846
73Vitamin B6 metabolism_Homo sapiens_hsa007500.76169684
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74681120
75mRNA surveillance pathway_Homo sapiens_hsa030150.72287945
76Glutathione metabolism_Homo sapiens_hsa004800.71766308
77Tight junction_Homo sapiens_hsa045300.70885820
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69366437
79Biosynthesis of amino acids_Homo sapiens_hsa012300.68040904
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66779487
81Sulfur metabolism_Homo sapiens_hsa009200.66743577
82Glioma_Homo sapiens_hsa052140.65868203
83Non-small cell lung cancer_Homo sapiens_hsa052230.63271501
84Glucagon signaling pathway_Homo sapiens_hsa049220.62757112
85ErbB signaling pathway_Homo sapiens_hsa040120.61884762
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61514142
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60872430
88Acute myeloid leukemia_Homo sapiens_hsa052210.60525312
89Arginine and proline metabolism_Homo sapiens_hsa003300.58845973
90Fat digestion and absorption_Homo sapiens_hsa049750.58638138
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58350951
92Folate biosynthesis_Homo sapiens_hsa007900.58033127
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57823274
94Galactose metabolism_Homo sapiens_hsa000520.57317785
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55811146
96beta-Alanine metabolism_Homo sapiens_hsa004100.55810839
97Insulin signaling pathway_Homo sapiens_hsa049100.55684039
98Starch and sucrose metabolism_Homo sapiens_hsa005000.54182839
99Fatty acid biosynthesis_Homo sapiens_hsa000610.53716514
100Steroid biosynthesis_Homo sapiens_hsa001000.53389970
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52796747
102Bile secretion_Homo sapiens_hsa049760.52531570
103Melanoma_Homo sapiens_hsa052180.52520585
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.51692081
105Pancreatic cancer_Homo sapiens_hsa052120.51218541
106Nucleotide excision repair_Homo sapiens_hsa034200.51175179
107Thyroid hormone synthesis_Homo sapiens_hsa049180.51128891
108Endometrial cancer_Homo sapiens_hsa052130.50689284
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49783917
110RNA transport_Homo sapiens_hsa030130.48859567
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48702510
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48140001
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.47165237
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44899001
115Colorectal cancer_Homo sapiens_hsa052100.44612778
116Ovarian steroidogenesis_Homo sapiens_hsa049130.44528623
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.44398395
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42479159
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40788932
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40137882
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37927898
122p53 signaling pathway_Homo sapiens_hsa041150.37495189
123Platelet activation_Homo sapiens_hsa046110.36952213
124Herpes simplex infection_Homo sapiens_hsa051680.36197764
125Pyruvate metabolism_Homo sapiens_hsa006200.34453686
126mTOR signaling pathway_Homo sapiens_hsa041500.34178539
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33937565
128Circadian rhythm_Homo sapiens_hsa047100.33741095
129Rap1 signaling pathway_Homo sapiens_hsa040150.33261482

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