SIX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)7.63773996
2detection of light stimulus involved in visual perception (GO:0050908)7.63773996
3retinal cone cell development (GO:0046549)7.08029182
4retinal rod cell development (GO:0046548)6.89011436
5response to pheromone (GO:0019236)6.79936404
6photoreceptor cell development (GO:0042461)5.88730703
7eye photoreceptor cell development (GO:0042462)5.82672511
8cardiac left ventricle morphogenesis (GO:0003214)5.82291631
9rhodopsin mediated signaling pathway (GO:0016056)5.36528367
10positive regulation of catecholamine secretion (GO:0033605)5.34723974
11regulation of rhodopsin mediated signaling pathway (GO:0022400)5.26926664
12intra-S DNA damage checkpoint (GO:0031573)5.10521092
13relaxation of smooth muscle (GO:0044557)5.09652072
14negative regulation of cytosolic calcium ion concentration (GO:0051481)5.06055359
15regulation of odontogenesis of dentin-containing tooth (GO:0042487)5.05879460
16photoreceptor cell maintenance (GO:0045494)5.03760216
17inositol phosphate dephosphorylation (GO:0046855)5.02816264
18phosphorylated carbohydrate dephosphorylation (GO:0046838)5.02816264
19protein-chromophore linkage (GO:0018298)4.90598305
20synaptic vesicle endocytosis (GO:0048488)4.81704018
21inositol phosphate catabolic process (GO:0071545)4.76608452
22regulation of spindle checkpoint (GO:0090231)4.55395542
23chromatin remodeling at centromere (GO:0031055)4.52571730
24ribosomal large subunit biogenesis (GO:0042273)4.36108555
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.24536216
26resolution of meiotic recombination intermediates (GO:0000712)4.23443334
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.22630862
28regulation of DNA endoreduplication (GO:0032875)4.14144730
29regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.11000051
30protein localization to synapse (GO:0035418)4.03124001
31* visual perception (GO:0007601)4.00085271
32* sensory perception of light stimulus (GO:0050953)3.99069236
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.98820420
34CENP-A containing nucleosome assembly (GO:0034080)3.97850458
35regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.94541796
36regulation of mitotic spindle checkpoint (GO:1903504)3.94541796
37regulation of non-canonical Wnt signaling pathway (GO:2000050)3.90131993
38germ cell migration (GO:0008354)3.87115965
39response to host immune response (GO:0052572)3.85206306
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.85206306
41synaptic vesicle exocytosis (GO:0016079)3.81756753
42convergent extension (GO:0060026)3.80539962
43behavioral response to nicotine (GO:0035095)3.68477719
44mitotic sister chromatid cohesion (GO:0007064)3.67084157
45regulation of synaptic vesicle exocytosis (GO:2000300)3.64518725
46detection of light stimulus (GO:0009583)3.57797978
47positive regulation of cGMP biosynthetic process (GO:0030828)3.53736934
48detection of visible light (GO:0009584)3.53341199
49regulation of short-term neuronal synaptic plasticity (GO:0048172)3.53222355
50DNA replication-independent nucleosome organization (GO:0034724)3.52298966
51DNA replication-independent nucleosome assembly (GO:0006336)3.52298966
52negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.50665569
53response to X-ray (GO:0010165)3.44161961
54establishment of integrated proviral latency (GO:0075713)3.42357700
55negative regulation of telomerase activity (GO:0051974)3.40649999
56atrial cardiac muscle cell action potential (GO:0086014)3.40099992
57photoreceptor cell differentiation (GO:0046530)3.39788193
58eye photoreceptor cell differentiation (GO:0001754)3.39788193
59heterochromatin organization (GO:0070828)3.39388194
60presynaptic membrane assembly (GO:0097105)3.39037188
61protein K6-linked ubiquitination (GO:0085020)3.34109579
62histone exchange (GO:0043486)3.33743033
63positive regulation of catenin import into nucleus (GO:0035413)3.32778486
64protein neddylation (GO:0045116)3.31992111
65response to host (GO:0075136)3.31377603
66response to host defenses (GO:0052200)3.31377603
67response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.31377603
68regulation of cGMP metabolic process (GO:0030823)3.27790366
69regulation of cGMP biosynthetic process (GO:0030826)3.27162460
70regulation of double-strand break repair via homologous recombination (GO:0010569)3.27007616
71calcium ion import (GO:0070509)3.22665765
72regulation of calcium ion import (GO:0090279)3.22492617
73negative regulation of translation, ncRNA-mediated (GO:0040033)3.22266696
74regulation of translation, ncRNA-mediated (GO:0045974)3.22266696
75negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.22266696
76nonmotile primary cilium assembly (GO:0035058)3.22000547
77determination of adult lifespan (GO:0008340)3.20988022
78retina development in camera-type eye (GO:0060041)3.20790906
79nitric oxide mediated signal transduction (GO:0007263)3.19501005
80presynaptic membrane organization (GO:0097090)3.19074567
81negative regulation of cell fate specification (GO:0009996)3.18310581
82positive regulation of cGMP metabolic process (GO:0030825)3.17348221
83dentate gyrus development (GO:0021542)3.17180970
84potassium ion homeostasis (GO:0055075)3.16006317
85regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.15475427
86regulation of synaptic vesicle transport (GO:1902803)3.15133344
87regulation of synapse maturation (GO:0090128)3.15063581
88positive regulation of calcium ion import (GO:0090280)3.14779323
89negative regulation of JUN kinase activity (GO:0043508)3.14617294
90phototransduction (GO:0007602)3.14532058
91DNA damage response, detection of DNA damage (GO:0042769)3.11449559
92sialylation (GO:0097503)3.10125038
93mitotic recombination (GO:0006312)3.09903049
94digestive tract morphogenesis (GO:0048546)3.09395597
95notochord development (GO:0030903)3.09297166
96startle response (GO:0001964)3.08212122
97membrane hyperpolarization (GO:0060081)3.03917648
98cGMP biosynthetic process (GO:0006182)3.03763228
99negative regulation of norepinephrine secretion (GO:0010700)3.03478851
100postsynaptic membrane organization (GO:0001941)3.01769224
101urinary tract smooth muscle contraction (GO:0014848)3.01483047
102positive regulation of DNA-dependent DNA replication (GO:2000105)3.00104073
103sequestering of actin monomers (GO:0042989)3.00100743
104protein localization to chromosome, centromeric region (GO:0071459)2.99173311
105establishment of synaptic vesicle localization (GO:0097480)2.98896738
106synaptic vesicle transport (GO:0048489)2.98896738
107regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.98425659
108polyol catabolic process (GO:0046174)2.97781139
109cellular potassium ion homeostasis (GO:0030007)2.97525820
110regulation of centriole replication (GO:0046599)2.96382123
111negative regulation of striated muscle cell apoptotic process (GO:0010664)2.96189321
112pre-miRNA processing (GO:0031054)2.95261138
113peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.94965126
114outer ear morphogenesis (GO:0042473)2.93777169
115DNA strand elongation involved in DNA replication (GO:0006271)2.93487216
116positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.93206889
117telomere maintenance via semi-conservative replication (GO:0032201)2.92740611
118phototransduction, visible light (GO:0007603)2.92624500
119innervation (GO:0060384)2.91766534
120positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.91072500
121negative regulation of cell fate commitment (GO:0010454)2.90736407
122telomere maintenance via recombination (GO:0000722)2.89923898
123regulation of neurotransmitter secretion (GO:0046928)2.89586063
124planar cell polarity pathway involved in neural tube closure (GO:0090179)2.89376605
125retina layer formation (GO:0010842)2.87186913
126righting reflex (GO:0060013)2.86801670
127DNA strand elongation (GO:0022616)2.86670592
128DNA replication checkpoint (GO:0000076)2.86190531
129kinetochore organization (GO:0051383)2.85249207
130energy homeostasis (GO:0097009)2.84831566
131nuclear pore organization (GO:0006999)2.84384975
132detection of bacterium (GO:0016045)2.82133827
133positive regulation of synapse maturation (GO:0090129)2.81520125
134regulation of helicase activity (GO:0051095)2.81319114
135behavioral response to ethanol (GO:0048149)2.80737582
136replication fork processing (GO:0031297)2.79006030
137negative regulation of membrane potential (GO:0045837)2.76761166
138auditory receptor cell stereocilium organization (GO:0060088)2.75219708
139cGMP metabolic process (GO:0046068)2.74582281
140negative regulation of DNA-dependent DNA replication (GO:2000104)2.73086573
141negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.72232458
142neurotransmitter-gated ion channel clustering (GO:0072578)2.71222335
143telomere maintenance via telomerase (GO:0007004)2.71136191
144detection of other organism (GO:0098543)2.70777472
145DNA unwinding involved in DNA replication (GO:0006268)2.69782945
146synaptic vesicle docking involved in exocytosis (GO:0016081)2.68175039
147detection of abiotic stimulus (GO:0009582)2.66968951
148vitamin A metabolic process (GO:0006776)2.66605382
149detection of external stimulus (GO:0009581)2.66548123
150negative regulation of DNA repair (GO:0045738)2.64997354
151positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.63694315
152mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.63694315
153long-term synaptic potentiation (GO:0060291)2.63059506
154pituitary gland development (GO:0021983)2.62800016
155regulation of timing of cell differentiation (GO:0048505)2.62092926
156regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.61517359
157nuclear pore complex assembly (GO:0051292)2.60210030
158behavioral response to cocaine (GO:0048148)2.59854969
159vocalization behavior (GO:0071625)2.59833669
160regulation of neurotransmitter transport (GO:0051588)2.59592512
161lactate metabolic process (GO:0006089)2.59292431
162protein localization to cilium (GO:0061512)2.59140945
163positive regulation of mRNA processing (GO:0050685)2.58933180
164sister chromatid cohesion (GO:0007062)2.58535451
165limb bud formation (GO:0060174)2.57796841
166regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56916709
167cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.56664550
168parturition (GO:0007567)2.56378007
169L-serine metabolic process (GO:0006563)2.56158266
170response to histamine (GO:0034776)2.56128793
171membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.55636586
172positive regulation of smoothened signaling pathway (GO:0045880)2.54901722
173estrogen biosynthetic process (GO:0006703)2.54758423
174inner ear receptor stereocilium organization (GO:0060122)2.54547853
175glucocorticoid biosynthetic process (GO:0006704)2.54365798
176post-anal tail morphogenesis (GO:0036342)2.54286725
177regulation of dopamine secretion (GO:0014059)2.54082219
178positive regulation of synaptic transmission, GABAergic (GO:0032230)2.54020595
179regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53770608
180negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.53724042
181negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.53724042
182negative regulation of mitotic sister chromatid segregation (GO:0033048)2.53724042
183negative regulation of mitotic sister chromatid separation (GO:2000816)2.53724042
184negative regulation of sister chromatid segregation (GO:0033046)2.53724042
185motor neuron axon guidance (GO:0008045)2.51298882
186calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.51150111
187positive regulation of gastrulation (GO:2000543)2.50869001
188pancreas development (GO:0031016)2.50729805
189retinal ganglion cell axon guidance (GO:0031290)2.47964418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.86598793
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.72443988
3GBX2_23144817_ChIP-Seq_PC3_Human4.29891472
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.83352171
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.63332944
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54372167
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.96807936
8EZH2_22144423_ChIP-Seq_EOC_Human2.84753596
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70513422
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.65323841
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.59616541
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.59616541
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.59616541
14* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.58756737
15AR_21909140_ChIP-Seq_LNCAP_Human2.51114809
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.35814311
17* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.31115930
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.30531542
19* EED_16625203_ChIP-ChIP_MESCs_Mouse2.27474817
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.25738021
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.23811284
22* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22396393
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18762081
24* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16995408
25SOX2_16153702_ChIP-ChIP_HESCs_Human2.16508528
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.12262333
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.11665647
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.11023898
29IRF1_19129219_ChIP-ChIP_H3396_Human2.08701402
30* EZH2_27294783_Chip-Seq_ESCs_Mouse2.06258848
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.05317010
32GABP_17652178_ChIP-ChIP_JURKAT_Human2.04033080
33FUS_26573619_Chip-Seq_HEK293_Human2.03015429
34* RNF2_27304074_Chip-Seq_NSC_Mouse2.02345105
35P300_19829295_ChIP-Seq_ESCs_Human2.00271744
36* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98928453
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.95855932
38* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94848353
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91790382
40* REST_21632747_ChIP-Seq_MESCs_Mouse1.90613836
41TAF15_26573619_Chip-Seq_HEK293_Human1.89649963
42CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88054112
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87601736
44* RNF2_27304074_Chip-Seq_ESCs_Mouse1.84819856
45NANOG_16153702_ChIP-ChIP_HESCs_Human1.83575492
46* SMAD4_21799915_ChIP-Seq_A2780_Human1.83352600
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82747406
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82560985
49* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.78786932
50* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.78786932
51* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78325774
52AR_21572438_ChIP-Seq_LNCaP_Human1.77550058
53* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73549698
54IGF1R_20145208_ChIP-Seq_DFB_Human1.69670764
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69054868
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.66225927
57ELK1_19687146_ChIP-ChIP_HELA_Human1.65754703
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.65101376
59* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64890105
60* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62972168
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.62153556
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.59168375
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58820747
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58400612
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58344041
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.56861544
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56562475
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.55179714
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.54808536
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54599479
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.52118648
72* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50772216
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49127508
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47848734
75HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46844926
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45552949
77SUZ12_18555785_Chip-Seq_ESCs_Mouse1.45416322
78DROSHA_22980978_ChIP-Seq_HELA_Human1.44129049
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.43379233
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41349113
81* AR_25329375_ChIP-Seq_VCAP_Human1.40610250
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.40262767
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37395727
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37054137
85KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36596175
86P53_22387025_ChIP-Seq_ESCs_Mouse1.34761573
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34100057
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.34002433
89* ER_23166858_ChIP-Seq_MCF-7_Human1.33821067
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33385367
91STAT3_23295773_ChIP-Seq_U87_Human1.32563898
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31385614
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31127168
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29981516
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.29691562
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.29433135
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29267540
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28389480
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.27596752
100EWS_26573619_Chip-Seq_HEK293_Human1.27475752
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27231028
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27012688
103* TCF4_23295773_ChIP-Seq_U87_Human1.26906059
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.26863789
105* REST_18959480_ChIP-ChIP_MESCs_Mouse1.25839845
106HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24770667
107MYC_19030024_ChIP-ChIP_MESCs_Mouse1.24219204
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23357956
109VDR_22108803_ChIP-Seq_LS180_Human1.21462891
110CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20057253
111NMYC_18555785_Chip-Seq_ESCs_Mouse1.18981511
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16146057
113CBP_20019798_ChIP-Seq_JUKART_Human1.16135017
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16135017
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15128361
116SOX2_18555785_Chip-Seq_ESCs_Mouse1.14427027
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14376692
118P300_18555785_Chip-Seq_ESCs_Mouse1.14074318
119GATA1_26923725_Chip-Seq_HPCs_Mouse1.14047320
120TAL1_26923725_Chip-Seq_HPCs_Mouse1.13700560
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.13626174
122TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11619128
123RUNX2_22187159_ChIP-Seq_PCA_Human1.10591732
124* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10567898
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10213704
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09524477
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09524477
128SOX9_26525672_Chip-Seq_HEART_Mouse1.08783373
129RUNX1_27457419_Chip-Seq_LIVER_Mouse1.08246805
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07695747
131ZFX_18555785_Chip-Seq_ESCs_Mouse1.07303843
132FOXP3_21729870_ChIP-Seq_TREG_Human1.06830551
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.06019724
134AR_19668381_ChIP-Seq_PC3_Human1.05384470
135PU1_27457419_Chip-Seq_LIVER_Mouse1.05234918
136E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04845093
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03799462
138ELK1_22589737_ChIP-Seq_MCF10A_Human1.03737608
139MYC_18940864_ChIP-ChIP_HL60_Human1.03623551
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02169838
141PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00617482
142JUN_21703547_ChIP-Seq_K562_Human0.99861879
143ISL1_27105846_Chip-Seq_CPCs_Mouse0.98628215
144ETV1_20927104_ChIP-Seq_GIST48_Human0.96924039
145ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95817401
146TBL1_22424771_ChIP-Seq_293T_Human0.95249734
147BCAT_22108803_ChIP-Seq_LS180_Human0.94558846
148MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92925485
149MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92753722
150CBP_21632823_ChIP-Seq_H3396_Human0.92020566
151ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91492724
152* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.90571383
153* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90271004
154PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.89831659
155* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89423605
156TTF2_22483619_ChIP-Seq_HELA_Human0.89154299
157SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88243715
158LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87893833
159TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87877480
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87376755
161NFYB_21822215_ChIP-Seq_K562_Human0.86946756
162MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86516754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog5.57476631
2MP0006072_abnormal_retinal_apoptosis5.05102723
3MP0006292_abnormal_olfactory_placode4.29651992
4MP0005253_abnormal_eye_physiology3.81092959
5MP0001502_abnormal_circadian_rhythm3.53007274
6MP0002638_abnormal_pupillary_reflex3.20184226
7MP0001293_anophthalmia3.14293335
8MP0004782_abnormal_surfactant_physiolog3.10187899
9MP0002090_abnormal_vision2.87757729
10MP0001984_abnormal_olfaction2.86025903
11MP0001188_hyperpigmentation2.62121556
12MP0003941_abnormal_skin_development2.56083542
13MP0008877_abnormal_DNA_methylation2.54548875
14MP0005645_abnormal_hypothalamus_physiol2.50328568
15MP0003011_delayed_dark_adaptation2.40506095
16* MP0005195_abnormal_posterior_eye2.34425886
17MP0005248_abnormal_Harderian_gland2.31013526
18MP0002822_catalepsy2.22271246
19MP0002233_abnormal_nose_morphology2.14939868
20MP0009278_abnormal_bone_marrow2.12149507
21MP0003122_maternal_imprinting2.09457408
22MP0001968_abnormal_touch/_nociception2.05659877
23MP0002277_abnormal_respiratory_mucosa1.99311901
24MP0001346_abnormal_lacrimal_gland1.96435906
25MP0002736_abnormal_nociception_after1.94823824
26MP0003878_abnormal_ear_physiology1.90047035
27MP0005377_hearing/vestibular/ear_phenot1.90047035
28MP0010386_abnormal_urinary_bladder1.89269598
29MP0005646_abnormal_pituitary_gland1.88073905
30MP0002102_abnormal_ear_morphology1.85749688
31MP0005391_vision/eye_phenotype1.83087796
32MP0006276_abnormal_autonomic_nervous1.80999905
33MP0005257_abnormal_intraocular_pressure1.80251067
34MP0001324_abnormal_eye_pigmentation1.80087633
35MP0005499_abnormal_olfactory_system1.79902551
36MP0005394_taste/olfaction_phenotype1.79902551
37MP0008789_abnormal_olfactory_epithelium1.75863093
38MP0001486_abnormal_startle_reflex1.75698184
39MP0001986_abnormal_taste_sensitivity1.74962163
40MP0002938_white_spotting1.74130409
41MP0010094_abnormal_chromosome_stability1.74010083
42MP0003880_abnormal_central_pattern1.65595534
43MP0003787_abnormal_imprinting1.65379027
44MP0005197_abnormal_uvea_morphology1.64261100
45MP0002876_abnormal_thyroid_physiology1.59138795
46MP0009672_abnormal_birth_weight1.57614826
47MP0009697_abnormal_copulation1.57285613
48MP0008932_abnormal_embryonic_tissue1.56026820
49MP0003121_genomic_imprinting1.55813540
50MP0002092_abnormal_eye_morphology1.53240906
51MP0009745_abnormal_behavioral_response1.51789048
52MP0003937_abnormal_limbs/digits/tail_de1.51256203
53MP0005423_abnormal_somatic_nervous1.49596753
54MP0008057_abnormal_DNA_replication1.49309437
55MP0008007_abnormal_cellular_replicative1.48522794
56MP0002064_seizures1.45529709
57MP0003077_abnormal_cell_cycle1.45430499
58MP0002063_abnormal_learning/memory/cond1.43833428
59* MP0002752_abnormal_somatic_nervous1.42439386
60MP0003635_abnormal_synaptic_transmissio1.41087636
61MP0002272_abnormal_nervous_system1.40118859
62MP0002184_abnormal_innervation1.38319966
63MP0002089_abnormal_postnatal_growth/wei1.37974664
64MP0008058_abnormal_DNA_repair1.36685674
65MP0003567_abnormal_fetal_cardiomyocyte1.36631038
66MP0005187_abnormal_penis_morphology1.36502834
67MP0003119_abnormal_digestive_system1.35879389
68MP0002067_abnormal_sensory_capabilities1.35794514
69MP0002735_abnormal_chemical_nociception1.35773672
70MP0002734_abnormal_mechanical_nocicepti1.32392882
71MP0003693_abnormal_embryo_hatching1.31867300
72MP0000428_abnormal_craniofacial_morphol1.31509670
73* MP0000631_abnormal_neuroendocrine_gland1.28954929
74MP0004197_abnormal_fetal_growth/weight/1.28802594
75MP0002132_abnormal_respiratory_system1.27227570
76MP0003111_abnormal_nucleus_morphology1.27196760
77MP0002572_abnormal_emotion/affect_behav1.25809481
78MP0001299_abnormal_eye_distance/1.24841027
79MP0009046_muscle_twitch1.22829558
80MP0002229_neurodegeneration1.20075491
81MP0002163_abnormal_gland_morphology1.19892775
82MP0008260_abnormal_autophagy1.18993583
83MP0003718_maternal_effect1.18972265
84MP0003950_abnormal_plasma_membrane1.18209812
85MP0002557_abnormal_social/conspecific_i1.13249947
86MP0001501_abnormal_sleep_pattern1.11582078
87MP0002882_abnormal_neuron_morphology1.10624859
88MP0004957_abnormal_blastocyst_morpholog1.07605518
89MP0005408_hypopigmentation1.06198909
90MP0005647_abnormal_sex_gland1.05832150
91MP0000778_abnormal_nervous_system1.05743260
92MP0005389_reproductive_system_phenotype1.04612128
93MP0004134_abnormal_chest_morphology1.02913616
94MP0005171_absent_coat_pigmentation1.00525445
95MP0009703_decreased_birth_body0.95710551
96MP0002751_abnormal_autonomic_nervous0.95485693
97MP0004859_abnormal_synaptic_plasticity0.95375367
98MP0010368_abnormal_lymphatic_system0.95226512
99MP0003890_abnormal_embryonic-extraembry0.93581385
100MP0003879_abnormal_hair_cell0.93200299
101MP0003861_abnormal_nervous_system0.91743335
102MP0001963_abnormal_hearing_physiology0.89820985
103MP0003183_abnormal_peptide_metabolism0.89113234
104MP0000566_synostosis0.88278446
105MP0004924_abnormal_behavior0.88263166
106MP0005386_behavior/neurological_phenoty0.88263166
107MP0005595_abnormal_vascular_smooth0.87264279
108MP0010030_abnormal_orbit_morphology0.85831860
109MP0002111_abnormal_tail_morphology0.85699127
110MP0000026_abnormal_inner_ear0.85476047
111MP0008004_abnormal_stomach_pH0.85188388
112MP0002697_abnormal_eye_size0.82507776
113MP0003755_abnormal_palate_morphology0.81846547
114MP0002332_abnormal_exercise_endurance0.81831801
115MP0004142_abnormal_muscle_tone0.81393674
116MP0004742_abnormal_vestibular_system0.79863892
117MP0000955_abnormal_spinal_cord0.79704780
118MP0005193_abnormal_anterior_eye0.77266555
119MP0002177_abnormal_outer_ear0.77041569
120MP0002234_abnormal_pharynx_morphology0.76855618
121MP0002116_abnormal_craniofacial_bone0.76076065
122MP0001970_abnormal_pain_threshold0.74535978
123MP0010352_gastrointestinal_tract_polyps0.72954152
124MP0000049_abnormal_middle_ear0.72839571
125MP0002109_abnormal_limb_morphology0.72521188
126MP0001879_abnormal_lymphatic_vessel0.72105372
127MP0000432_abnormal_head_morphology0.71835968
128MP0001286_abnormal_eye_development0.71621802
129MP0001529_abnormal_vocalization0.70969494
130MP0008775_abnormal_heart_ventricle0.70578890
131MP0002932_abnormal_joint_morphology0.68795606
132MP0002160_abnormal_reproductive_system0.68754908
133MP0004272_abnormal_basement_membrane0.68287839
134MP0000653_abnormal_sex_gland0.67572632
135MP0005670_abnormal_white_adipose0.67238783
136MP0000516_abnormal_urinary_system0.66771602
137MP0005367_renal/urinary_system_phenotyp0.66771602
138MP0002653_abnormal_ependyma_morphology0.66596461
139MP0001929_abnormal_gametogenesis0.65137393
140MP0002069_abnormal_eating/drinking_beha0.65136001
141MP0001545_abnormal_hematopoietic_system0.64927647
142MP0005397_hematopoietic_system_phenotyp0.64927647
143MP0001177_atelectasis0.62505937
144MP0004147_increased_porphyrin_level0.62505641
145MP0004215_abnormal_myocardial_fiber0.61373091
146MP0001919_abnormal_reproductive_system0.61057858
147MP0005379_endocrine/exocrine_gland_phen0.59849039
148MP0004233_abnormal_muscle_weight0.56604900
149MP0003634_abnormal_glial_cell0.54256221
150MP0003123_paternal_imprinting0.52993518
151MP0000678_abnormal_parathyroid_gland0.52208393
152MP0000681_abnormal_thyroid_gland0.52020653
153MP0002066_abnormal_motor_capabilities/c0.51909694

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)6.09562785
2Abnormal rod and cone electroretinograms (HP:0008323)6.08310781
3Abnormality of macular pigmentation (HP:0008002)5.78212643
4Severe visual impairment (HP:0001141)5.77057901
5Septo-optic dysplasia (HP:0100842)5.53425999
6Pendular nystagmus (HP:0012043)5.33103999
7Bony spicule pigmentary retinopathy (HP:0007737)5.25742757
8Stenosis of the external auditory canal (HP:0000402)5.08225544
9Decreased central vision (HP:0007663)5.03829082
10Absent rod-and cone-mediated responses on ERG (HP:0007688)4.99655441
11Febrile seizures (HP:0002373)4.88669722
12Spinal cord lesions (HP:0100561)4.53885732
13Syringomyelia (HP:0003396)4.53885732
14Scotoma (HP:0000575)4.51434622
15Dyschromatopsia (HP:0007641)4.27481395
16Limb dystonia (HP:0002451)4.06755759
17Epileptic encephalopathy (HP:0200134)3.92655075
18Abolished electroretinogram (ERG) (HP:0000550)3.83778018
19Cutaneous melanoma (HP:0012056)3.78827213
20Increased corneal curvature (HP:0100692)3.78577543
21Keratoconus (HP:0000563)3.78577543
22Attenuation of retinal blood vessels (HP:0007843)3.73723530
23Chorioretinal atrophy (HP:0000533)3.50606894
24Midline defect of the nose (HP:0004122)3.47976185
25Rectovaginal fistula (HP:0000143)3.41843704
26Rectal fistula (HP:0100590)3.41843704
27Hypoplasia of the fovea (HP:0007750)3.40799040
28Aplasia/Hypoplasia of the fovea (HP:0008060)3.40799040
29True hermaphroditism (HP:0010459)3.40583912
30Pigmentary retinal degeneration (HP:0001146)3.36779523
31Optic nerve hypoplasia (HP:0000609)3.29574394
32Abnormal hair whorl (HP:0010721)3.23102799
33Median cleft lip (HP:0000161)3.18021000
34Increased serum pyruvate (HP:0003542)3.17663939
35Vaginal fistula (HP:0004320)3.16546243
36Photophobia (HP:0000613)3.16125361
37Abnormality of the fovea (HP:0000493)2.97960505
38Abnormality of cells of the erythroid lineage (HP:0012130)2.96165316
39Absence seizures (HP:0002121)2.95451340
40Facial cleft (HP:0002006)2.93475246
41Congenital sensorineural hearing impairment (HP:0008527)2.93012079
42Intestinal fistula (HP:0100819)2.86242789
43Focal motor seizures (HP:0011153)2.86039286
44Anophthalmia (HP:0000528)2.83674864
45Irregular epiphyses (HP:0010582)2.79829113
46Abnormality of glycolysis (HP:0004366)2.79615918
47Intestinal atresia (HP:0011100)2.77133837
48Type II diabetes mellitus (HP:0005978)2.69591268
49Absent septum pellucidum (HP:0001331)2.68862385
50Bifid tongue (HP:0010297)2.67542433
51Pancreatic fibrosis (HP:0100732)2.65189380
52Aplasia/Hypoplasia of the macula (HP:0008059)2.61397089
53Cone-rod dystrophy (HP:0000548)2.61204350
54Medial flaring of the eyebrow (HP:0010747)2.60792078
55Vitreoretinal degeneration (HP:0000655)2.56777014
56Dialeptic seizures (HP:0011146)2.55411180
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.51000252
58Nephrogenic diabetes insipidus (HP:0009806)2.49717626
59Hypoplasia of the ulna (HP:0003022)2.46853132
60Gait imbalance (HP:0002141)2.46063208
61Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.45530850
62Abnormality of incisor morphology (HP:0011063)2.45491226
63Congenital primary aphakia (HP:0007707)2.44633954
64Retinitis pigmentosa (HP:0000510)2.41924554
65Constricted visual fields (HP:0001133)2.40516888
66Growth hormone deficiency (HP:0000824)2.38344873
67Postaxial hand polydactyly (HP:0001162)2.35446497
68Dysphonia (HP:0001618)2.34426363
69Abnormality of the septum pellucidum (HP:0007375)2.32297381
70Submucous cleft hard palate (HP:0000176)2.31734735
71Gonadotropin excess (HP:0000837)2.31615560
72Partial agenesis of the corpus callosum (HP:0001338)2.30245841
73Subcapsular cataract (HP:0000523)2.29324722
74Mitral stenosis (HP:0001718)2.28708127
75Squamous cell carcinoma (HP:0002860)2.26875354
76Abnormality of midbrain morphology (HP:0002418)2.26100722
77Molar tooth sign on MRI (HP:0002419)2.26100722
78Colon cancer (HP:0003003)2.25125944
79Birth length less than 3rd percentile (HP:0003561)2.22148605
80Choroideremia (HP:0001139)2.22070404
81Cleft eyelid (HP:0000625)2.21888098
82Rhabdomyosarcoma (HP:0002859)2.21525368
83Partial duplication of thumb phalanx (HP:0009944)2.20451054
84Abnormality of the lumbar spine (HP:0100712)2.20423981
85Aplasia/Hypoplasia affecting the retina (HP:0008061)2.20301290
86Hip dysplasia (HP:0001385)2.19417689
87Chronic hepatic failure (HP:0100626)2.18737230
88Triphalangeal thumb (HP:0001199)2.17605018
89Hemiparesis (HP:0001269)2.15583767
90Abnormality of the phalanges of the hallux (HP:0010057)2.14752389
91Macular degeneration (HP:0000608)2.13934613
92Volvulus (HP:0002580)2.12779722
93Omphalocele (HP:0001539)2.09977974
94Prolonged QT interval (HP:0001657)2.09478686
95Albinism (HP:0001022)2.08615601
96Metaphyseal cupping (HP:0003021)2.08351684
97Pancreatic cysts (HP:0001737)2.07986571
98Optic nerve coloboma (HP:0000588)2.06911338
99Medulloblastoma (HP:0002885)2.06715882
100Atonic seizures (HP:0010819)2.06048926
101Posterior subcapsular cataract (HP:0007787)2.04953907
102Poor coordination (HP:0002370)2.01696224
103Entropion (HP:0000621)2.01392466
104Absent thumb (HP:0009777)2.01169947
105Aplasia/Hypoplasia of the lens (HP:0008063)2.00928572
106Hypoglycemic seizures (HP:0002173)2.00202105
107Congenital stationary night blindness (HP:0007642)10.4881526
108Aplasia/Hypoplasia of the ulna (HP:0006495)1.99794125
109Polyphagia (HP:0002591)1.98421681
110Aplasia/Hypoplasia of the tongue (HP:0010295)1.97867223
111Cortical dysplasia (HP:0002539)1.95112439
112Renal hypoplasia (HP:0000089)1.95105310
113Duplication of thumb phalanx (HP:0009942)1.94045675
114Poikiloderma (HP:0001029)1.93430791
115Reticulocytopenia (HP:0001896)1.92604498
116Optic disc pallor (HP:0000543)1.92546790
117Hypoplastic ischia (HP:0003175)1.92159940
118Macrocytic anemia (HP:0001972)1.90360090
119Abnormality of the phalanges of the 2nd finger (HP:0009541)1.87969311
120Embryonal renal neoplasm (HP:0011794)1.87744769
121Basal cell carcinoma (HP:0002671)1.87408890
122Abnormality of DNA repair (HP:0003254)1.87022777
123Generalized hypopigmentation (HP:0007513)1.83194393
124Nephronophthisis (HP:0000090)1.82928382
125Pallor (HP:0000980)1.80851874
126Sclerocornea (HP:0000647)1.80233407
127Short ribs (HP:0000773)1.78237023
128Abnormality of alanine metabolism (HP:0010916)1.78061998
129Hyperalaninemia (HP:0003348)1.78061998
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.78061998
131Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.77027218
132Partial duplication of the phalanx of hand (HP:0009999)1.76897727
133Abnormality of the pons (HP:0007361)1.76483016
134Abnormality of the nasal septum (HP:0000419)1.75340897
135Narrow nasal bridge (HP:0000446)1.75233844
136Progressive cerebellar ataxia (HP:0002073)1.74912539
137Hyperventilation (HP:0002883)1.73058481
138Progressive visual loss (HP:0000529)1.71569331
139Astigmatism (HP:0000483)1.71317123
140Aplasia involving bones of the upper limbs (HP:0009823)1.69180612
141Aplasia of the phalanges of the hand (HP:0009802)1.69180612
142Aplasia involving bones of the extremities (HP:0009825)1.69180612
143Nasolacrimal duct obstruction (HP:0000579)1.67232084
144Absent speech (HP:0001344)1.66267025
145Congenital hepatic fibrosis (HP:0002612)1.66261505
146Severe Myopia (HP:0011003)1.65765117
147Visual hallucinations (HP:0002367)1.65583163
148Focal seizures (HP:0007359)1.65275700
149Tubulointerstitial nephritis (HP:0001970)1.65064841
150Esotropia (HP:0000565)1.63552658
151Abnormality of the labia minora (HP:0012880)1.60318612
152Abnormality of the renal medulla (HP:0100957)1.59351574
153Chromosomal breakage induced by crosslinking agents (HP:0003221)1.57655563
154Abdominal situs inversus (HP:0003363)1.56551314
155Abnormality of abdominal situs (HP:0011620)1.56551314
156Vaginal atresia (HP:0000148)1.56221340
157* Chorioretinal coloboma (HP:0000567)1.56149460
158Preaxial hand polydactyly (HP:0001177)1.55328723
159Poor suck (HP:0002033)1.54304489
160Genital tract atresia (HP:0001827)1.53835215
161Abnormal EKG (HP:0003115)1.52349180
162Postaxial foot polydactyly (HP:0001830)1.52002020
163Flat capital femoral epiphysis (HP:0003370)1.47922670
164Fetal akinesia sequence (HP:0001989)1.45924311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CA6.21988925
2CASK4.15408502
3CDC73.72867916
4AKT33.47875491
5PRPF4B3.34111000
6STK243.14919782
7DYRK33.12473734
8INSRR2.89042172
9NUAK12.82312252
10GRK12.74575421
11SIK32.71003531
12ERBB32.70020317
13PASK2.37097839
14NEK12.29860140
15MAP2K72.23030647
16SGK22.22469987
17CDK32.18505380
18STK32.18159897
19TTK2.11066017
20NTRK32.09514135
21CDK192.08937569
22SGK2232.04444423
23SGK4942.04444423
24DYRK22.03448736
25ZAK2.00919570
26TNIK1.87625311
27BMPR21.75846907
28DYRK1A1.72791551
29BUB11.71127467
30NTRK21.56698741
31PINK11.56018509
32IRAK21.54514449
33ADRBK21.52566896
34MAPK131.50499812
35PLK21.49203830
36TAOK21.48243445
37NLK1.47922332
38SGK31.36598633
39TRIM281.34405925
40TGFBR11.33321532
41MARK11.33287341
42BMPR1B1.32617596
43YES11.31577895
44TXK1.31015711
45MAP3K41.27022704
46PLK11.26498610
47PBK1.22778372
48WEE11.19636778
49DYRK1B1.18330071
50CAMK1D1.18146677
51PRKCE1.18121573
52MAP3K121.17420646
53BCR1.13300780
54CAMKK21.11736061
55LMTK21.10620193
56MAP4K21.06215492
57TNK21.01649769
58FRK1.00186781
59PRKD30.98689441
60MKNK20.89575581
61PKN10.86352977
62ARAF0.85722250
63BRAF0.85237737
64MAP3K140.84457247
65PRKCG0.82955604
66WNK30.82267821
67IRAK30.81164488
68CSNK1G10.80776626
69CAMK40.80500124
70CCNB10.80073976
71NEK60.77639154
72EPHA30.77452135
73DAPK10.77158237
74CAMK1G0.76291102
75SGK10.75944950
76CHEK20.75752015
77PLK30.74616060
78BRD40.72806212
79ACVR1B0.72580182
80AURKB0.70498145
81CAMK10.70483820
82CAMK2D0.69542302
83CDK80.69215066
84DAPK20.66527924
85MINK10.66250314
86PLK40.65781040
87KSR10.64255079
88CSNK1G20.63074873
89RPS6KB10.62508324
90GRK70.61471561
91TSSK60.61376648
92PRKAA10.61338273
93SIK20.61184353
94ATR0.61119690
95MAP3K100.60916615
96CAMK2A0.60582011
97MAPK70.59679783
98VRK20.59382587
99NME10.58876531
100ADRBK10.58210472
101PRKG10.57340078
102RPS6KA50.54965553
103LIMK10.54011476
104IRAK10.53753778
105CHUK0.53607263
106TGFBR20.52966261
107EIF2AK20.52893487
108PRKACA0.50985945
109ILK0.50200567
110VRK10.49180945
111STK38L0.48533755
112STK160.48521402
113ATM0.48252761
114RPS6KA20.45824875
115MKNK10.45652175
116SRPK10.44040570
117CSNK2A20.43738923
118TIE10.43248662
119TLK10.42840600
120DMPK0.41469364
121MAP3K130.41164148
122TESK10.41121683
123PRKG20.40674269
124PNCK0.40327092
125OBSCN0.40310677
126CHEK10.39785226
127PRKCA0.39747585
128PRKCZ0.39393841
129PHKG10.39358724
130PHKG20.39358724
131MAPK150.39222400
132CAMKK10.39201187
133PRKCB0.38203794
134PAK60.37143959
135GRK50.36901755
136CSNK1G30.36663301
137PTK20.35532135
138EIF2AK10.35478495
139CAMK2G0.35249285
140PAK30.34141697
141PRKDC0.33895694
142EPHB20.33892057
143TAF10.33839471
144GSK3B0.32829459
145ALK0.32236007
146LATS10.32034679
147AKT10.31505662
148CSNK2A10.30882195
149STK40.29356203
150BCKDK0.28090056
151TESK20.27669770
152AURKA0.27112125
153CDK10.26730646
154FLT30.25371334
155FGFR10.25158012
156CDK20.24725837
157RPS6KA40.23980310
158OXSR10.22979559
159PTK2B0.18005990
160CSNK1E0.17616581
161AKT20.17555776

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047446.39317116
2Sulfur relay system_Homo sapiens_hsa041224.76669331
3Nicotine addiction_Homo sapiens_hsa050334.55863018
4Mismatch repair_Homo sapiens_hsa034304.16031846
5Synaptic vesicle cycle_Homo sapiens_hsa047213.40307187
6DNA replication_Homo sapiens_hsa030303.28969107
7GABAergic synapse_Homo sapiens_hsa047273.14684990
8Morphine addiction_Homo sapiens_hsa050323.03946525
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72959848
10Circadian rhythm_Homo sapiens_hsa047102.57508742
11Olfactory transduction_Homo sapiens_hsa047402.56682198
12Pyruvate metabolism_Homo sapiens_hsa006202.47784704
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47548138
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.42516181
15Circadian entrainment_Homo sapiens_hsa047132.39708461
16Nucleotide excision repair_Homo sapiens_hsa034202.37787505
17Protein export_Homo sapiens_hsa030602.34140483
18Ribosome_Homo sapiens_hsa030102.25536718
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.14383029
20Non-homologous end-joining_Homo sapiens_hsa034502.08080839
21Homologous recombination_Homo sapiens_hsa034402.05331965
22Collecting duct acid secretion_Homo sapiens_hsa049661.95123381
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.91995961
24Folate biosynthesis_Homo sapiens_hsa007901.87533890
25Fatty acid elongation_Homo sapiens_hsa000621.85154748
26Proteasome_Homo sapiens_hsa030501.83507168
27Insulin secretion_Homo sapiens_hsa049111.83337871
28Cell cycle_Homo sapiens_hsa041101.82502187
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.77861592
30Serotonergic synapse_Homo sapiens_hsa047261.72277164
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.70500671
32Basal transcription factors_Homo sapiens_hsa030221.70224314
33RNA transport_Homo sapiens_hsa030131.68364630
34Biosynthesis of amino acids_Homo sapiens_hsa012301.65856777
35Base excision repair_Homo sapiens_hsa034101.65298160
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62399712
37Basal cell carcinoma_Homo sapiens_hsa052171.61989657
38Rheumatoid arthritis_Homo sapiens_hsa053231.61284473
39Cholinergic synapse_Homo sapiens_hsa047251.57813104
40Hedgehog signaling pathway_Homo sapiens_hsa043401.56213009
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54270557
42Glutamatergic synapse_Homo sapiens_hsa047241.51468284
43Pentose phosphate pathway_Homo sapiens_hsa000301.51014234
44Vitamin B6 metabolism_Homo sapiens_hsa007501.49784824
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48150143
46Selenocompound metabolism_Homo sapiens_hsa004501.46223787
47Taste transduction_Homo sapiens_hsa047421.43188586
48Renin secretion_Homo sapiens_hsa049241.39042995
49Steroid biosynthesis_Homo sapiens_hsa001001.38301927
50Spliceosome_Homo sapiens_hsa030401.35854019
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34382976
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33671714
53Salivary secretion_Homo sapiens_hsa049701.32004421
54Type I diabetes mellitus_Homo sapiens_hsa049401.28835887
55Graft-versus-host disease_Homo sapiens_hsa053321.28642677
56Fructose and mannose metabolism_Homo sapiens_hsa000511.27175713
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24767475
58p53 signaling pathway_Homo sapiens_hsa041151.24370828
59Hippo signaling pathway_Homo sapiens_hsa043901.22243532
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21499997
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21181568
62Autoimmune thyroid disease_Homo sapiens_hsa053201.20067676
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19811278
64Carbon metabolism_Homo sapiens_hsa012001.18756985
65Vibrio cholerae infection_Homo sapiens_hsa051101.18013638
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.16698152
67Oxytocin signaling pathway_Homo sapiens_hsa049211.13051273
68Propanoate metabolism_Homo sapiens_hsa006401.10012593
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01538546
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99504076
71Calcium signaling pathway_Homo sapiens_hsa040200.98733612
72Dopaminergic synapse_Homo sapiens_hsa047280.95682433
73Long-term depression_Homo sapiens_hsa047300.93348532
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91814191
75One carbon pool by folate_Homo sapiens_hsa006700.91764715
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90195906
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89891660
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88794411
79Cardiac muscle contraction_Homo sapiens_hsa042600.88724772
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88501529
81Melanoma_Homo sapiens_hsa052180.88496245
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88363877
83Alcoholism_Homo sapiens_hsa050340.87688566
84Mineral absorption_Homo sapiens_hsa049780.85288816
85Allograft rejection_Homo sapiens_hsa053300.84760357
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81972799
87Pyrimidine metabolism_Homo sapiens_hsa002400.80200063
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78601185
89cAMP signaling pathway_Homo sapiens_hsa040240.78227335
90Dilated cardiomyopathy_Homo sapiens_hsa054140.77678786
91mRNA surveillance pathway_Homo sapiens_hsa030150.76428633
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74279689
93Type II diabetes mellitus_Homo sapiens_hsa049300.73730345
94Thyroid cancer_Homo sapiens_hsa052160.73063258
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72332658
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71112924
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69686200
98TGF-beta signaling pathway_Homo sapiens_hsa043500.69420882
99Oocyte meiosis_Homo sapiens_hsa041140.68121170
100Phagosome_Homo sapiens_hsa041450.67762483
101African trypanosomiasis_Homo sapiens_hsa051430.65986936
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65608322
103Amphetamine addiction_Homo sapiens_hsa050310.64962974
104RNA polymerase_Homo sapiens_hsa030200.63907911
105Inositol phosphate metabolism_Homo sapiens_hsa005620.63225806
106Adherens junction_Homo sapiens_hsa045200.61028914
107Parkinsons disease_Homo sapiens_hsa050120.60636762
108Glutathione metabolism_Homo sapiens_hsa004800.59687117
109Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59681832
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59330620
111Cocaine addiction_Homo sapiens_hsa050300.59292502
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.59116464
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57209099
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56846108
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56520395
116Ovarian steroidogenesis_Homo sapiens_hsa049130.55523137
117MAPK signaling pathway_Homo sapiens_hsa040100.53648742
118Fanconi anemia pathway_Homo sapiens_hsa034600.50318234
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50134378
120Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49357008
121Galactose metabolism_Homo sapiens_hsa000520.48574846
122Axon guidance_Homo sapiens_hsa043600.47963101
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44457600
124Systemic lupus erythematosus_Homo sapiens_hsa053220.44161296
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43324416
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43034012
127Metabolic pathways_Homo sapiens_hsa011000.42726122
128Oxidative phosphorylation_Homo sapiens_hsa001900.42505518
129Huntingtons disease_Homo sapiens_hsa050160.42494695
130ABC transporters_Homo sapiens_hsa020100.42247081
131Sphingolipid metabolism_Homo sapiens_hsa006000.40238578
132Butanoate metabolism_Homo sapiens_hsa006500.38705952
133Purine metabolism_Homo sapiens_hsa002300.38616390
134Wnt signaling pathway_Homo sapiens_hsa043100.37740411
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37528033
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35828271
137TNF signaling pathway_Homo sapiens_hsa046680.35424011
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35318755
139Gap junction_Homo sapiens_hsa045400.34865888
140Ras signaling pathway_Homo sapiens_hsa040140.34836711
141Endometrial cancer_Homo sapiens_hsa052130.32970095
142Colorectal cancer_Homo sapiens_hsa052100.32893109
143RNA degradation_Homo sapiens_hsa030180.32582816
144Intestinal immune network for IgA production_Homo sapiens_hsa046720.32513990
145HIF-1 signaling pathway_Homo sapiens_hsa040660.30596697
146Legionellosis_Homo sapiens_hsa051340.29836831
147Chemokine signaling pathway_Homo sapiens_hsa040620.29102508
148Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29089257
149Lysine degradation_Homo sapiens_hsa003100.29077776
150Regulation of autophagy_Homo sapiens_hsa041400.28598618
151Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26899764
152Maturity onset diabetes of the young_Homo sapiens_hsa049500.25375345
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24816984
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.24011442
155MicroRNAs in cancer_Homo sapiens_hsa052060.23655796
156Tuberculosis_Homo sapiens_hsa051520.22691164
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22342736
158ErbB signaling pathway_Homo sapiens_hsa040120.22123035
159Viral carcinogenesis_Homo sapiens_hsa052030.21993338
160Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21691279
161Drug metabolism - other enzymes_Homo sapiens_hsa009830.20525833
162Pathways in cancer_Homo sapiens_hsa052000.20225210
163Retinol metabolism_Homo sapiens_hsa008300.19847614
164Asthma_Homo sapiens_hsa053100.18822341
165Fatty acid metabolism_Homo sapiens_hsa012120.18358840
166Central carbon metabolism in cancer_Homo sapiens_hsa052300.18335525
167Vitamin digestion and absorption_Homo sapiens_hsa049770.18014667
168Arginine and proline metabolism_Homo sapiens_hsa003300.17713753
169Tight junction_Homo sapiens_hsa045300.17676909
170N-Glycan biosynthesis_Homo sapiens_hsa005100.16838877
171Arachidonic acid metabolism_Homo sapiens_hsa005900.16257732

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