SKA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.77535418
2protein localization to kinetochore (GO:0034501)5.55607343
3kinetochore organization (GO:0051383)5.13566894
4protein localization to chromosome, centromeric region (GO:0071459)5.11089484
5CENP-A containing nucleosome assembly (GO:0034080)5.10515241
6DNA replication checkpoint (GO:0000076)5.03255526
7metaphase plate congression (GO:0051310)5.02045374
8chromatin remodeling at centromere (GO:0031055)4.97676915
9attachment of spindle microtubules to kinetochore (GO:0008608)4.77808191
10kinetochore assembly (GO:0051382)4.71190658
11mitotic chromosome condensation (GO:0007076)4.70521071
12DNA strand elongation involved in DNA replication (GO:0006271)4.66048478
13mitotic sister chromatid segregation (GO:0000070)4.62183199
14establishment of chromosome localization (GO:0051303)4.57653993
15regulation of spindle organization (GO:0090224)4.57018335
16DNA replication-independent nucleosome organization (GO:0034724)4.53878646
17DNA replication-independent nucleosome assembly (GO:0006336)4.53878646
18DNA replication initiation (GO:0006270)4.53741997
19telomere maintenance via semi-conservative replication (GO:0032201)4.47604112
20DNA strand elongation (GO:0022616)4.42400600
21replication fork processing (GO:0031297)4.32474035
22regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.30964551
23histone exchange (GO:0043486)4.30552017
24sister chromatid segregation (GO:0000819)4.18109948
25regulation of DNA endoreduplication (GO:0032875)4.16692726
26telomere maintenance via recombination (GO:0000722)4.09828432
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.03452359
28DNA replication-dependent nucleosome organization (GO:0034723)4.00816798
29DNA replication-dependent nucleosome assembly (GO:0006335)4.00816798
30mitotic recombination (GO:0006312)4.00538403
31negative regulation of DNA-dependent DNA replication (GO:2000104)4.00306063
32meiotic chromosome segregation (GO:0045132)4.00283947
33mitotic nuclear envelope disassembly (GO:0007077)3.99986518
34spindle checkpoint (GO:0031577)3.95123097
35regulation of mitotic spindle organization (GO:0060236)3.94243875
36synapsis (GO:0007129)3.84598851
37maturation of SSU-rRNA (GO:0030490)3.84298992
38DNA unwinding involved in DNA replication (GO:0006268)3.76674432
39regulation of chromosome segregation (GO:0051983)3.74328416
40nucleobase biosynthetic process (GO:0046112)3.71588481
41protein localization to chromosome (GO:0034502)3.71426194
42nuclear envelope disassembly (GO:0051081)3.70297373
43membrane disassembly (GO:0030397)3.70297373
44telomere maintenance via telomere lengthening (GO:0010833)3.70095769
45negative regulation of chromosome segregation (GO:0051985)3.68777060
46DNA double-strand break processing (GO:0000729)3.67235549
47negative regulation of mitotic sister chromatid separation (GO:2000816)3.67235178
48negative regulation of mitotic sister chromatid segregation (GO:0033048)3.67235178
49negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.67235178
50negative regulation of sister chromatid segregation (GO:0033046)3.67235178
51spindle assembly checkpoint (GO:0071173)3.65260063
52regulation of mitotic metaphase/anaphase transition (GO:0030071)3.62394722
53nuclear pore organization (GO:0006999)3.62115916
54purine nucleobase biosynthetic process (GO:0009113)3.61825259
55regulation of centriole replication (GO:0046599)3.60830033
56positive regulation of chromosome segregation (GO:0051984)3.60086139
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.59466364
58regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.56501558
59* chromosome segregation (GO:0007059)3.56449550
60mitotic spindle assembly checkpoint (GO:0007094)3.54782543
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.52410788
62somatic hypermutation of immunoglobulin genes (GO:0016446)3.52410788
63mitotic spindle checkpoint (GO:0071174)3.51126941
64DNA ligation (GO:0006266)3.49948222
65resolution of meiotic recombination intermediates (GO:0000712)3.49524512
66protein K6-linked ubiquitination (GO:0085020)3.47610208
67ribosomal large subunit biogenesis (GO:0042273)3.45001105
68regulation of double-strand break repair via homologous recombination (GO:0010569)3.43159275
69nuclear pore complex assembly (GO:0051292)3.43139989
70chromatin assembly or disassembly (GO:0006333)3.42480112
71regulation of mitotic sister chromatid separation (GO:0010965)3.42108170
72regulation of mitotic sister chromatid segregation (GO:0033047)3.42108170
73regulation of sister chromatid segregation (GO:0033045)3.42108170
74ribosomal small subunit assembly (GO:0000028)3.41093539
75recombinational repair (GO:0000725)3.39893227
76spliceosomal snRNP assembly (GO:0000387)3.38827981
77DNA deamination (GO:0045006)3.38252504
78viral transcription (GO:0019083)3.37869096
79translational termination (GO:0006415)3.37465983
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.36585167
81double-strand break repair via homologous recombination (GO:0000724)3.35698299
82ribosomal small subunit biogenesis (GO:0042274)3.29557301
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29539307
84ATP-dependent chromatin remodeling (GO:0043044)3.28274328
85ribonucleoprotein complex biogenesis (GO:0022613)3.28258882
86regulation of sister chromatid cohesion (GO:0007063)3.28200555
87ribosome biogenesis (GO:0042254)3.27192785
88formation of translation preinitiation complex (GO:0001731)3.26040193
89ribosome assembly (GO:0042255)3.23751732
90regulation of mitotic spindle checkpoint (GO:1903504)3.21197900
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.21197900
92centriole replication (GO:0007099)3.19552340
93chromosome condensation (GO:0030261)3.19108805
94positive regulation of mitotic sister chromatid separation (GO:1901970)3.18734945
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.18734945
96positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.18734945
97microtubule depolymerization (GO:0007019)3.18353383
98postreplication repair (GO:0006301)3.17473736
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16816819
100DNA catabolic process, exonucleolytic (GO:0000738)3.16190221
101rRNA processing (GO:0006364)3.14879954
102maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.14607057
103regulation of exit from mitosis (GO:0007096)3.14498393
104regulation of centrosome cycle (GO:0046605)3.13127498
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.12585704
106DNA strand renaturation (GO:0000733)3.11962782
107translational initiation (GO:0006413)3.11701207
108* mitotic cell cycle (GO:0000278)3.11057785
109establishment of protein localization to mitochondrial membrane (GO:0090151)3.10347349
110transcription-coupled nucleotide-excision repair (GO:0006283)3.09760915
111spliceosomal complex assembly (GO:0000245)3.08528603
112mitotic sister chromatid cohesion (GO:0007064)3.08195481
113mitotic G2/M transition checkpoint (GO:0044818)3.05370442
114regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04573764
115rRNA metabolic process (GO:0016072)3.04556573
116proteasome assembly (GO:0043248)3.03097311
117regulation of nuclear cell cycle DNA replication (GO:0033262)3.02760845
118translational elongation (GO:0006414)3.02555622
119deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.02265940
120centrosome organization (GO:0051297)3.00394499
121rRNA modification (GO:0000154)2.97611833
122G1/S transition of mitotic cell cycle (GO:0000082)2.95550519
123cell cycle G1/S phase transition (GO:0044843)2.95550519
124RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93204924
125cullin deneddylation (GO:0010388)2.91384630
126double-strand break repair via nonhomologous end joining (GO:0006303)2.91037905
127non-recombinational repair (GO:0000726)2.91037905
128maturation of 5.8S rRNA (GO:0000460)2.87403841
129regulation of centrosome duplication (GO:0010824)2.86459152
130translesion synthesis (GO:0019985)2.85740746
131isotype switching (GO:0045190)2.85428223
132somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85428223
133somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85428223
134negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80695248
135DNA recombination (GO:0006310)2.79090086
136reciprocal DNA recombination (GO:0035825)2.76137841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.00666587
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.04124673
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.37525401
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.10013558
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.09791349
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55616240
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34799450
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94097728
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.92739770
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.85249994
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78456371
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.77767923
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.76316717
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75827712
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.70011406
16AR_21909140_ChIP-Seq_LNCAP_Human2.69732861
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69620742
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.47119563
19XRN2_22483619_ChIP-Seq_HELA_Human2.38456394
20ZNF274_21170338_ChIP-Seq_K562_Hela2.37120028
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.35506342
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33153645
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31070561
24VDR_22108803_ChIP-Seq_LS180_Human2.22070109
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.18024646
26VDR_23849224_ChIP-Seq_CD4+_Human2.16210997
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12855410
28EWS_26573619_Chip-Seq_HEK293_Human2.04183685
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02822212
30DCP1A_22483619_ChIP-Seq_HELA_Human2.01126918
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96033720
32FOXP3_21729870_ChIP-Seq_TREG_Human1.91746205
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91611645
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88380429
35TTF2_22483619_ChIP-Seq_HELA_Human1.87085473
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86730740
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80718702
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.79714339
39GABP_19822575_ChIP-Seq_HepG2_Human1.79618723
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79500693
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77843116
42FUS_26573619_Chip-Seq_HEK293_Human1.75660919
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72252232
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67591812
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64655257
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63435424
47ELK1_19687146_ChIP-ChIP_HELA_Human1.61465601
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61331001
49IGF1R_20145208_ChIP-Seq_DFB_Human1.58301658
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56195253
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53428670
52IRF1_19129219_ChIP-ChIP_H3396_Human1.52106294
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.52068205
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49590977
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48601720
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46556839
57KDM5A_27292631_Chip-Seq_BREAST_Human1.44789518
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.44017386
59CIITA_25753668_ChIP-Seq_RAJI_Human1.43943554
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41804824
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39055307
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38551004
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.35172433
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31069408
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30392618
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30333909
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27379288
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.26121100
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25199298
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22690637
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21600818
72SRF_21415370_ChIP-Seq_HL-1_Mouse1.20253327
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18783023
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16104174
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15789092
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15439488
77MYC_22102868_ChIP-Seq_BL_Human1.12246948
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11191778
79P300_19829295_ChIP-Seq_ESCs_Human1.10734015
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10668218
81STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10046971
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09940508
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08182171
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07564636
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06837758
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06523056
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05911653
88MYC_18940864_ChIP-ChIP_HL60_Human1.05136982
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05111941
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.04241266
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.03828884
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02027573
93CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00451501
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99979649
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97819013
96TP53_22573176_ChIP-Seq_HFKS_Human0.95611167
97PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95589884
98CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95322776
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95257752
100TAF15_26573619_Chip-Seq_HEK293_Human0.94491851
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94476505
102NANOG_21062744_ChIP-ChIP_HESCs_Human0.93037485
103RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92912837
104TFEB_21752829_ChIP-Seq_HELA_Human0.92148325
105PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90965148
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90150308
107ER_23166858_ChIP-Seq_MCF-7_Human0.90029092
108KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88510356
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87960137
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86770148
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84917383
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84139024
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.83720496
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80259784
115GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78813108
116FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78436913
117FOXA1_25329375_ChIP-Seq_VCAP_Human0.78436913
118EZH2_27294783_Chip-Seq_NPCs_Mouse0.78218719
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.78185644
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77914983
121CBP_20019798_ChIP-Seq_JUKART_Human0.77914983
122SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.77403741
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77049929
124VDR_21846776_ChIP-Seq_THP-1_Human0.76410927
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76091571
126TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75204282
127GBX2_23144817_ChIP-Seq_PC3_Human0.74893935
128SOX2_19829295_ChIP-Seq_ESCs_Human0.74816883
129NANOG_19829295_ChIP-Seq_ESCs_Human0.74816883
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74654744
131SPI1_23547873_ChIP-Seq_NB4_Human0.74372366
132HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74172830
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74066862
134AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72836239
135MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.72071486
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.71937217
137CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.70845508
138SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70553488
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.68746106
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.67871689
141SOX17_20123909_ChIP-Seq_XEN_Mouse0.67300269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.44325194
2MP0003111_abnormal_nucleus_morphology5.20697446
3MP0010094_abnormal_chromosome_stability4.97221546
4MP0004957_abnormal_blastocyst_morpholog4.78153259
5MP0003077_abnormal_cell_cycle4.51085668
6MP0008057_abnormal_DNA_replication4.03740219
7MP0008058_abnormal_DNA_repair3.33488260
8MP0008932_abnormal_embryonic_tissue3.05559616
9MP0008007_abnormal_cellular_replicative3.04511085
10MP0000372_irregular_coat_pigmentation2.78219825
11MP0008877_abnormal_DNA_methylation2.56283174
12MP0001730_embryonic_growth_arrest2.37593625
13MP0003718_maternal_effect2.36482941
14MP0000350_abnormal_cell_proliferation2.30818296
15MP0003123_paternal_imprinting2.23371202
16MP0002938_white_spotting2.14610106
17MP0003786_premature_aging2.06930215
18MP0009697_abnormal_copulation1.99750877
19MP0006072_abnormal_retinal_apoptosis1.87746154
20MP0010307_abnormal_tumor_latency1.87153516
21MP0005380_embryogenesis_phenotype1.84373865
22MP0001672_abnormal_embryogenesis/_devel1.84373865
23MP0002396_abnormal_hematopoietic_system1.78426865
24MP0001697_abnormal_embryo_size1.76611995
25MP0003195_calcinosis1.75087913
26MP0002085_abnormal_embryonic_tissue1.61147926
27MP0002080_prenatal_lethality1.58379589
28MP0003984_embryonic_growth_retardation1.56329036
29MP0002210_abnormal_sex_determination1.55391285
30MP0002088_abnormal_embryonic_growth/wei1.53159007
31MP0000313_abnormal_cell_death1.50111463
32MP0005171_absent_coat_pigmentation1.48051884
33MP0000490_abnormal_crypts_of1.47577925
34MP0003315_abnormal_perineum_morphology1.47161232
35MP0010030_abnormal_orbit_morphology1.42339726
36MP0002095_abnormal_skin_pigmentation1.40847306
37MP0002019_abnormal_tumor_incidence1.36639379
38MP0002084_abnormal_developmental_patter1.35456091
39MP0006292_abnormal_olfactory_placode1.34941082
40MP0002086_abnormal_extraembryonic_tissu1.34800569
41MP0001145_abnormal_male_reproductive1.33100090
42MP0001929_abnormal_gametogenesis1.32013490
43MP0005551_abnormal_eye_electrophysiolog1.31156407
44MP0005174_abnormal_tail_pigmentation1.30899038
45MP0005075_abnormal_melanosome_morpholog1.30896420
46MP0005253_abnormal_eye_physiology1.28960903
47MP0004808_abnormal_hematopoietic_stem1.27938064
48MP0008995_early_reproductive_senescence1.27749284
49MP0000631_abnormal_neuroendocrine_gland1.26731869
50MP0000427_abnormal_hair_cycle1.25614747
51MP0003646_muscle_fatigue1.25028399
52MP0010352_gastrointestinal_tract_polyps1.24333278
53MP0000569_abnormal_digit_pigmentation1.23976931
54MP0009053_abnormal_anal_canal1.23743290
55MP0008872_abnormal_physiological_respon1.23260498
56MP0000653_abnormal_sex_gland1.20517212
57MP0003121_genomic_imprinting1.17755062
58MP0005076_abnormal_cell_differentiation1.16700497
59MP0006035_abnormal_mitochondrial_morpho1.16392381
60MP0001529_abnormal_vocalization1.13430614
61MP0003567_abnormal_fetal_cardiomyocyte1.13279009
62MP0005408_hypopigmentation1.13253751
63MP0004197_abnormal_fetal_growth/weight/1.12946624
64MP0009333_abnormal_splenocyte_physiolog1.12869703
65MP0002736_abnormal_nociception_after1.09123985
66MP0003890_abnormal_embryonic-extraembry1.07222435
67MP0001119_abnormal_female_reproductive1.06246019
68MP0001545_abnormal_hematopoietic_system1.05292562
69MP0005397_hematopoietic_system_phenotyp1.05292562
70MP0002234_abnormal_pharynx_morphology1.04844537
71MP0002837_dystrophic_cardiac_calcinosis1.04557659
72MP0002102_abnormal_ear_morphology1.04260142
73MP0005084_abnormal_gallbladder_morpholo1.03382382
74MP0003937_abnormal_limbs/digits/tail_de1.02724606
75MP0009379_abnormal_foot_pigmentation1.01430684
76MP0002160_abnormal_reproductive_system1.01378161
77MP0001293_anophthalmia1.00318923
78MP0000647_abnormal_sebaceous_gland0.99269478
79MP0000015_abnormal_ear_pigmentation0.98403488
80MP0000703_abnormal_thymus_morphology0.92502031
81MP0003941_abnormal_skin_development0.91766541
82MP0005389_reproductive_system_phenotype0.89176255
83MP0002277_abnormal_respiratory_mucosa0.88851352
84MP0003950_abnormal_plasma_membrane0.88306853
85MP0001485_abnormal_pinna_reflex0.86872603
86MP0001324_abnormal_eye_pigmentation0.85895502
87MP0005645_abnormal_hypothalamus_physiol0.85796540
88MP0003806_abnormal_nucleotide_metabolis0.82956256
89MP0002638_abnormal_pupillary_reflex0.82767407
90MP0002111_abnormal_tail_morphology0.82188956
91MP0003119_abnormal_digestive_system0.81970561
92MP0002233_abnormal_nose_morphology0.81231967
93MP0003221_abnormal_cardiomyocyte_apopto0.81062444
94MP0003938_abnormal_ear_development0.81010686
95MP0002132_abnormal_respiratory_system0.80928506
96MP0002751_abnormal_autonomic_nervous0.80456136
97MP0005391_vision/eye_phenotype0.79770349
98MP0009672_abnormal_birth_weight0.79290554
99MP0005379_endocrine/exocrine_gland_phen0.79107067
100MP0002398_abnormal_bone_marrow0.78215207
101MP0000858_altered_metastatic_potential0.76950656
102MP0002722_abnormal_immune_system0.76868611
103MP0001919_abnormal_reproductive_system0.75431495
104MP0000689_abnormal_spleen_morphology0.74681686
105MP0001968_abnormal_touch/_nociception0.74071098
106MP0003656_abnormal_erythrocyte_physiolo0.73939834
107MP0003699_abnormal_female_reproductive0.73294401
108MP0005384_cellular_phenotype0.72693279
109MP0001286_abnormal_eye_development0.72544975
110MP0005621_abnormal_cell_physiology0.71924475
111MP0003943_abnormal_hepatobiliary_system0.71480035
112MP0000358_abnormal_cell_content/0.70375054
113MP0003186_abnormal_redox_activity0.69604582
114MP0006054_spinal_hemorrhage0.69371292
115MP0009046_muscle_twitch0.68486379
116MP0005195_abnormal_posterior_eye0.68353891
117MP0003763_abnormal_thymus_physiology0.66922333
118MP0004142_abnormal_muscle_tone0.64951864
119MP0000428_abnormal_craniofacial_morphol0.64270494
120MP0003698_abnormal_male_reproductive0.64149741
121MP0005395_other_phenotype0.63590643
122MP0003936_abnormal_reproductive_system0.63351590
123MP0002161_abnormal_fertility/fecundity0.63034270
124MP0002653_abnormal_ependyma_morphology0.62844266
125MP0003136_yellow_coat_color0.60905044
126MP0003755_abnormal_palate_morphology0.59735524
127MP0002429_abnormal_blood_cell0.59462151
128MP0000432_abnormal_head_morphology0.56365425
129MP0008789_abnormal_olfactory_epithelium0.56057544
130MP0001727_abnormal_embryo_implantation0.55718105
131MP0009703_decreased_birth_body0.54773322
132MP0004133_heterotaxia0.53874758
133MP0002092_abnormal_eye_morphology0.53344882
134MP0005023_abnormal_wound_healing0.53164143
135MP0006036_abnormal_mitochondrial_physio0.53046380
136MP0001915_intracranial_hemorrhage0.51861450
137MP0004147_increased_porphyrin_level0.50652927
138MP0003935_abnormal_craniofacial_develop0.50584769
139MP0000049_abnormal_middle_ear0.48853229
140MP0002163_abnormal_gland_morphology0.48510621
141MP0000537_abnormal_urethra_morphology0.46078325
142MP0009278_abnormal_bone_marrow0.45733777

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.62488651
2Breast hypoplasia (HP:0003187)4.73685499
3Chromsome breakage (HP:0040012)4.58069587
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.50653964
5Reticulocytopenia (HP:0001896)4.36892148
6Patellar aplasia (HP:0006443)4.27182033
7Aplasia/Hypoplasia of the patella (HP:0006498)4.02387307
8Carpal bone hypoplasia (HP:0001498)3.82147954
9Meckel diverticulum (HP:0002245)3.81631243
10Abnormality of the preputium (HP:0100587)3.65571501
11Abnormality of the ileum (HP:0001549)3.60755420
12Abnormality of chromosome stability (HP:0003220)3.58893896
13Abnormality of cells of the erythroid lineage (HP:0012130)3.57689307
14Abnormal number of erythroid precursors (HP:0012131)3.55493482
15Oral leukoplakia (HP:0002745)3.48873833
16Aplasia/Hypoplasia of the uvula (HP:0010293)3.35162787
17Small intestinal stenosis (HP:0012848)3.32748511
18Duodenal stenosis (HP:0100867)3.32748511
19Impulsivity (HP:0100710)3.29386990
20Absent radius (HP:0003974)3.25754780
21Rough bone trabeculation (HP:0100670)3.05651101
22Absent forearm bone (HP:0003953)3.03447336
23Aplasia involving forearm bones (HP:0009822)3.03447336
24Medulloblastoma (HP:0002885)2.99299926
25Abnormality of the labia minora (HP:0012880)2.97883727
26Myelodysplasia (HP:0002863)2.91148090
27Colon cancer (HP:0003003)2.88504954
28Macrocytic anemia (HP:0001972)2.88189408
29Aplastic anemia (HP:0001915)2.87943683
30Horseshoe kidney (HP:0000085)2.85922529
31Pancreatic cysts (HP:0001737)2.83799504
32Abnormal lung lobation (HP:0002101)2.77975194
33Selective tooth agenesis (HP:0001592)2.77740527
34Absent thumb (HP:0009777)2.77706392
35Abnormality of the anterior horn cell (HP:0006802)2.73239769
36Degeneration of anterior horn cells (HP:0002398)2.73239769
37Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.71145387
38Rhabdomyosarcoma (HP:0002859)2.71018252
39Pallor (HP:0000980)2.70581990
40Abnormality of the duodenum (HP:0002246)2.68321114
41Triphalangeal thumb (HP:0001199)2.67709231
42Facial hemangioma (HP:0000329)2.67157311
43Cleft eyelid (HP:0000625)2.63473361
44Microretrognathia (HP:0000308)2.63037449
45Sloping forehead (HP:0000340)2.57339143
46Abnormality of alanine metabolism (HP:0010916)2.57166851
47Hyperalaninemia (HP:0003348)2.57166851
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57166851
49Secondary amenorrhea (HP:0000869)2.57044995
50Bone marrow hypocellularity (HP:0005528)2.56463655
51Molar tooth sign on MRI (HP:0002419)2.55909081
52Abnormality of midbrain morphology (HP:0002418)2.55909081
53Aplasia/Hypoplasia of the sacrum (HP:0008517)2.53772651
54Pancreatic fibrosis (HP:0100732)2.53058042
55Volvulus (HP:0002580)2.52296204
56Supernumerary spleens (HP:0009799)2.52213801
57Pendular nystagmus (HP:0012043)2.51217845
58Acute necrotizing encephalopathy (HP:0006965)2.50693378
59Duplicated collecting system (HP:0000081)2.45937826
60Ectopic kidney (HP:0000086)2.45175316
61Hypoplasia of the capital femoral epiphysis (HP:0003090)2.44669454
62Acute encephalopathy (HP:0006846)2.43918322
63Nephroblastoma (Wilms tumor) (HP:0002667)2.41826492
64Cerebral hypomyelination (HP:0006808)2.41792446
65Neoplasm of the pancreas (HP:0002894)2.39490427
66Congenital stationary night blindness (HP:0007642)2.38047489
67Septo-optic dysplasia (HP:0100842)2.37374578
68Tracheoesophageal fistula (HP:0002575)2.36472668
69Premature graying of hair (HP:0002216)2.35888411
70Increased CSF lactate (HP:0002490)2.33605840
71Abnormality of the pons (HP:0007361)2.33504985
72Abnormal trabecular bone morphology (HP:0100671)2.32181325
73Premature ovarian failure (HP:0008209)2.29756360
74Embryonal renal neoplasm (HP:0011794)2.25769102
75Short thumb (HP:0009778)2.25614627
76True hermaphroditism (HP:0010459)2.24283293
77Atresia of the external auditory canal (HP:0000413)2.22995348
78Abnormality of the carotid arteries (HP:0005344)2.20149097
79Hypoplasia of the pons (HP:0012110)2.19364532
80Clubbing of toes (HP:0100760)2.19275077
81Trismus (HP:0000211)2.16939849
82Neoplasm of the adrenal cortex (HP:0100641)2.16880907
83Small hand (HP:0200055)2.16855974
84Progressive macrocephaly (HP:0004481)2.16789677
85Nephronophthisis (HP:0000090)2.15266806
86Cafe-au-lait spot (HP:0000957)2.14549637
87Abnormal mitochondria in muscle tissue (HP:0008316)2.11637249
88Ependymoma (HP:0002888)2.10951128
89Abnormal number of incisors (HP:0011064)2.10455696
90Increased nuchal translucency (HP:0010880)2.09423969
91Mitochondrial inheritance (HP:0001427)2.08850091
9211 pairs of ribs (HP:0000878)2.08123839
93Abnormality of the heme biosynthetic pathway (HP:0010472)2.06455087
94Oligodactyly (HP:0012165)2.05883577
95Abnormality of the renal collecting system (HP:0004742)2.05802833
96Methylmalonic acidemia (HP:0002912)2.05469071
97Ureteral duplication (HP:0000073)2.04709526
98Cellular immunodeficiency (HP:0005374)2.03848208
99Multiple enchondromatosis (HP:0005701)2.02859950
100Agnosia (HP:0010524)2.01625950
101Hypoplasia of the fovea (HP:0007750)2.00257320
102Aplasia/Hypoplasia of the fovea (HP:0008060)2.00257320
103Slender long bone (HP:0003100)1.99823470
104Capillary hemangiomas (HP:0005306)1.98721331
105Intestinal atresia (HP:0011100)1.98021117
106Abnormal spermatogenesis (HP:0008669)1.97608305
107Abnormality of the renal cortex (HP:0011035)1.97230377
108Progressive inability to walk (HP:0002505)1.95900608
109Aplasia/Hypoplasia of the sternum (HP:0006714)1.95474427
110Basal cell carcinoma (HP:0002671)1.95181827
111Astigmatism (HP:0000483)1.94623091
112Increased serum lactate (HP:0002151)1.92779549
113Squamous cell carcinoma (HP:0002860)1.91204578
114Oligodactyly (hands) (HP:0001180)1.90900196
115Increased hepatocellular lipid droplets (HP:0006565)1.87692937
116Neoplasm of striated muscle (HP:0009728)1.86707636
117Overlapping toe (HP:0001845)1.83427241
118Glioma (HP:0009733)1.83175556
119Aplasia/Hypoplasia of the breasts (HP:0010311)1.83004539
120Abnormality of DNA repair (HP:0003254)1.82990904
121Lipid accumulation in hepatocytes (HP:0006561)1.82640547
122Neoplasm of the colon (HP:0100273)1.81620685
123Medial flaring of the eyebrow (HP:0010747)1.81321324
124Absent septum pellucidum (HP:0001331)1.81000619
125Abnormality of the renal medulla (HP:0100957)1.80459140
126Breast aplasia (HP:0100783)1.80094072
127Abnormality of reticulocytes (HP:0004312)1.79796115
128Absent epiphyses (HP:0010577)1.79382877
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79382877
130Dandy-Walker malformation (HP:0001305)1.79353010
131Aplasia/Hypoplasia of the earlobes (HP:0009906)1.78549985
132Oligohydramnios (HP:0001562)1.77872053
133Pancytopenia (HP:0001876)1.77158835
134Arteriovenous malformation (HP:0100026)1.76996401
135Congenital, generalized hypertrichosis (HP:0004540)1.76644172
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74791267
137Abdominal situs inversus (HP:0003363)1.74560851
138Abnormality of abdominal situs (HP:0011620)1.74560851
139Prominent nose (HP:0000448)1.73949481
140Methylmalonic aciduria (HP:0012120)1.73729817
141Irregular epiphyses (HP:0010582)1.73718281
142Neoplasm of the adrenal gland (HP:0100631)1.73471510
143Hepatocellular necrosis (HP:0001404)1.72593810
144Short middle phalanx of the 5th finger (HP:0004220)1.71563466
145Sclerocornea (HP:0000647)1.71406234
146Abnormality of pyrimidine metabolism (HP:0004353)1.70967372
147Optic nerve hypoplasia (HP:0000609)1.69396837
148Preaxial hand polydactyly (HP:0001177)1.69198312
149Abnormality of the fovea (HP:0000493)1.68297782
150Abnormality of serum amino acid levels (HP:0003112)1.67758380
151Attenuation of retinal blood vessels (HP:0007843)1.67110325
152Type II lissencephaly (HP:0007260)1.65501035
153Pancreatic islet-cell hyperplasia (HP:0004510)1.64077429
154Lissencephaly (HP:0001339)1.62058898
155Cerebral edema (HP:0002181)1.61861363
156Abnormality of the septum pellucidum (HP:0007375)1.61490626
157Hypoplastic pelvis (HP:0008839)1.58555760
158Hepatic necrosis (HP:0002605)1.57753038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.58283805
2WEE14.83758846
3CDC74.12931927
4EIF2AK13.54156861
5NEK23.27450239
6TTK2.87262190
7FRK2.83863354
8BRSK22.76179211
9SRPK12.71948096
10PLK42.54921573
11NEK12.50350191
12BMPR1B2.49966868
13TLK12.42929242
14PLK12.41675017
15NME22.38306459
16TRIM282.37471524
17VRK22.36196222
18NUAK12.31658295
19ACVR1B2.28592063
20AURKB2.02884469
21BRSK12.00282278
22CCNB11.91889265
23TESK21.88976467
24MST41.85243958
25VRK11.82576733
26STK161.80456751
27TAF11.77662469
28MKNK11.72817362
29WNK31.71847707
30DYRK31.69188123
31CHEK21.66774813
32MKNK21.66581050
33CDK71.64308521
34EIF2AK31.61330360
35PLK31.59264738
36AURKA1.50136602
37ATR1.48416800
38RPS6KA41.47505747
39MAP3K81.34263326
40STK41.31552815
41MAP4K21.26811301
42STK101.22398883
43CDK41.21915784
44CHEK11.19786421
45PLK21.17902623
46MELK1.17149595
47GRK11.15674623
48PBK1.13588280
49ADRBK21.09620357
50TNIK1.04795184
51WNK41.03758598
52CDK81.01405531
53EPHA20.97243902
54EIF2AK20.96913467
55TSSK60.96255708
56ZAK0.93604134
57RPS6KB20.92416960
58CDK120.88634732
59ERBB30.88138648
60BRAF0.88048656
61ATM0.86559767
62PAK40.84336255
63PDK20.83012059
64CDK20.82447308
65BCR0.81248093
66STK390.80660745
67LATS20.78821435
68STK30.77650863
69STK38L0.76862716
70INSRR0.76166317
71PIM10.75579931
72CLK10.73075651
73PASK0.72866368
74CDK10.71324660
75PAK10.67047898
76CSNK2A10.66397328
77CDK60.66202186
78MAP3K40.64739802
79CSNK1G10.60669732
80MAPK130.59280017
81RPS6KA50.59264727
82OXSR10.59016362
83CSNK2A20.55814346
84MAP3K110.53321806
85ERBB40.53282352
86CSNK1G30.50777436
87PINK10.48268692
88DYRK20.46379049
89NEK90.46066892
90KDR0.46053646
91TESK10.45258427
92PRKCI0.45023497
93ALK0.44853869
94CSNK1G20.43215272
95MAPKAPK50.42725456
96CSNK1A1L0.42029385
97ADRBK10.39907205
98FGFR20.39245549
99NME10.38011564
100BRD40.37178504
101LATS10.36842979
102TGFBR10.36730520
103ABL20.36084115
104PRKCG0.35888980
105MAP3K60.34608648
106MAP3K100.34086909
107PIM20.33630627
108MARK30.33514272
109TAOK30.33252080
110AKT30.33045549
111CDK30.31832845
112PNCK0.29637435
113NLK0.28695795
114IRAK30.28350599
115EEF2K0.27584342
116SCYL20.27049664
117LRRK20.26550066
118PRKDC0.25962754
119MAP4K10.25052402
120CDK11A0.24282047
121AKT20.24104317
122PRKCE0.23100264
123CDK150.20427663
124CDK90.20063593
125PAK30.19188403
126CSNK1E0.18552107
127CSNK1A10.18486764
128CSNK1D0.18338446
129PKN10.18235791
130MAPK140.18149425
131CDK180.17975452
132LIMK10.16333045
133MAPK110.16227634
134CDK140.15382726
135AKT10.15334517
136MAPKAPK30.14538067
137MAPKAPK20.12379939
138FLT30.11613603
139RPS6KA10.11255717
140IRAK40.11241969
141MAP3K50.10596050

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.09079931
2Mismatch repair_Homo sapiens_hsa034304.24052257
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.71459572
4Ribosome_Homo sapiens_hsa030103.47366790
5Homologous recombination_Homo sapiens_hsa034403.43646697
6RNA polymerase_Homo sapiens_hsa030203.43393991
7Spliceosome_Homo sapiens_hsa030403.33781405
8Cell cycle_Homo sapiens_hsa041103.28629348
9RNA transport_Homo sapiens_hsa030133.17497517
10Base excision repair_Homo sapiens_hsa034103.09546561
11Nucleotide excision repair_Homo sapiens_hsa034202.97552166
12Proteasome_Homo sapiens_hsa030502.97440789
13Fanconi anemia pathway_Homo sapiens_hsa034602.73413538
14Pyrimidine metabolism_Homo sapiens_hsa002402.60188991
15One carbon pool by folate_Homo sapiens_hsa006702.40746636
16Basal transcription factors_Homo sapiens_hsa030222.32044327
17RNA degradation_Homo sapiens_hsa030181.93615324
18Non-homologous end-joining_Homo sapiens_hsa034501.87957530
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84454120
20p53 signaling pathway_Homo sapiens_hsa041151.83591011
21mRNA surveillance pathway_Homo sapiens_hsa030151.81451724
22Vitamin B6 metabolism_Homo sapiens_hsa007501.41529562
23Phototransduction_Homo sapiens_hsa047441.41262510
24Propanoate metabolism_Homo sapiens_hsa006401.40937038
25Oocyte meiosis_Homo sapiens_hsa041141.40913358
26Systemic lupus erythematosus_Homo sapiens_hsa053221.39701250
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38112973
28Purine metabolism_Homo sapiens_hsa002301.37854257
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24722960
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24380121
31Epstein-Barr virus infection_Homo sapiens_hsa051691.20746482
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13071934
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08767052
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01438100
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00683953
36Butanoate metabolism_Homo sapiens_hsa006500.99137237
37Herpes simplex infection_Homo sapiens_hsa051680.94783894
38Pentose phosphate pathway_Homo sapiens_hsa000300.93455757
39Steroid biosynthesis_Homo sapiens_hsa001000.92285317
40Pyruvate metabolism_Homo sapiens_hsa006200.92046000
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.89553293
42Viral carcinogenesis_Homo sapiens_hsa052030.89297717
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89223325
44Nitrogen metabolism_Homo sapiens_hsa009100.86995649
45Folate biosynthesis_Homo sapiens_hsa007900.86326663
46Alzheimers disease_Homo sapiens_hsa050100.85568518
47Sulfur relay system_Homo sapiens_hsa041220.83617735
48Caffeine metabolism_Homo sapiens_hsa002320.79932268
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76219578
50Tryptophan metabolism_Homo sapiens_hsa003800.76202147
51Sulfur metabolism_Homo sapiens_hsa009200.75363513
52Protein export_Homo sapiens_hsa030600.74125366
53HTLV-I infection_Homo sapiens_hsa051660.73719857
54MicroRNAs in cancer_Homo sapiens_hsa052060.69111990
55Fatty acid elongation_Homo sapiens_hsa000620.68668365
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.68107175
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68002662
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.67249789
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.66194582
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63245478
61Biosynthesis of amino acids_Homo sapiens_hsa012300.61911463
62Huntingtons disease_Homo sapiens_hsa050160.61421322
63Small cell lung cancer_Homo sapiens_hsa052220.59257128
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58108608
65Antigen processing and presentation_Homo sapiens_hsa046120.56727873
66Selenocompound metabolism_Homo sapiens_hsa004500.56443762
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55696369
68Thyroid cancer_Homo sapiens_hsa052160.53322589
69Ether lipid metabolism_Homo sapiens_hsa005650.52268518
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49933321
71Glutathione metabolism_Homo sapiens_hsa004800.49665699
72Peroxisome_Homo sapiens_hsa041460.48722395
73Alcoholism_Homo sapiens_hsa050340.47105497
74Olfactory transduction_Homo sapiens_hsa047400.47048764
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45955469
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43740008
77TGF-beta signaling pathway_Homo sapiens_hsa043500.43031662
78Lysine degradation_Homo sapiens_hsa003100.42792266
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39442167
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39055884
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38458619
82Hippo signaling pathway_Homo sapiens_hsa043900.37082362
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36774356
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36082010
85Apoptosis_Homo sapiens_hsa042100.35578636
86Bladder cancer_Homo sapiens_hsa052190.35248281
87Hepatitis B_Homo sapiens_hsa051610.35047911
88Nicotine addiction_Homo sapiens_hsa050330.35008389
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34956487
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34869544
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34192670
92Parkinsons disease_Homo sapiens_hsa050120.33267312
93Basal cell carcinoma_Homo sapiens_hsa052170.32508174
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.30132201
95Cardiac muscle contraction_Homo sapiens_hsa042600.28735177
96beta-Alanine metabolism_Homo sapiens_hsa004100.28235773
97Legionellosis_Homo sapiens_hsa051340.27697422
98Colorectal cancer_Homo sapiens_hsa052100.27473770
99Retinol metabolism_Homo sapiens_hsa008300.26746950
100Taste transduction_Homo sapiens_hsa047420.26544953
101Vitamin digestion and absorption_Homo sapiens_hsa049770.25668581
102Carbon metabolism_Homo sapiens_hsa012000.25266896
103Arachidonic acid metabolism_Homo sapiens_hsa005900.23569979
104Fatty acid metabolism_Homo sapiens_hsa012120.22464822
105Shigellosis_Homo sapiens_hsa051310.21521436
106Hedgehog signaling pathway_Homo sapiens_hsa043400.20837168
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20797468
108Fatty acid degradation_Homo sapiens_hsa000710.20544941
109Primary immunodeficiency_Homo sapiens_hsa053400.19645192
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.19378065
111Metabolic pathways_Homo sapiens_hsa011000.19231300
112Pathways in cancer_Homo sapiens_hsa052000.18463124
113Measles_Homo sapiens_hsa051620.18041180
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17720337
115Notch signaling pathway_Homo sapiens_hsa043300.17589875
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.17122058
117FoxO signaling pathway_Homo sapiens_hsa040680.16826314
118Regulation of autophagy_Homo sapiens_hsa041400.16176683
119Chronic myeloid leukemia_Homo sapiens_hsa052200.15777112
120Prostate cancer_Homo sapiens_hsa052150.15759049
121HIF-1 signaling pathway_Homo sapiens_hsa040660.15103189
122Influenza A_Homo sapiens_hsa051640.14078679
123N-Glycan biosynthesis_Homo sapiens_hsa005100.13484110
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13190452
125Fructose and mannose metabolism_Homo sapiens_hsa000510.12383969
126Melanoma_Homo sapiens_hsa052180.11365477
127Hematopoietic cell lineage_Homo sapiens_hsa046400.09995114
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.09831310
129Wnt signaling pathway_Homo sapiens_hsa043100.09269079
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.07837452
131Linoleic acid metabolism_Homo sapiens_hsa005910.07322116
132Oxidative phosphorylation_Homo sapiens_hsa001900.07135241
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06187710
134Non-small cell lung cancer_Homo sapiens_hsa052230.06089143
135mTOR signaling pathway_Homo sapiens_hsa041500.05246189
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.05146921
137Pancreatic cancer_Homo sapiens_hsa052120.04929035
138Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04262538
139Galactose metabolism_Homo sapiens_hsa000520.04211617
140Renin-angiotensin system_Homo sapiens_hsa046140.02467031

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