SKA2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.31287609
2viral transcription (GO:0019083)7.17603875
3translational termination (GO:0006415)7.14340278
4cotranslational protein targeting to membrane (GO:0006613)6.00742581
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.95237645
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.95194791
7protein targeting to ER (GO:0045047)5.80695445
8translational elongation (GO:0006414)5.70932375
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.53717856
10protein localization to endoplasmic reticulum (GO:0070972)5.44692029
11cellular protein complex disassembly (GO:0043624)5.42701971
12viral life cycle (GO:0019058)5.23052121
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.20697428
14ATP synthesis coupled proton transport (GO:0015986)5.08720904
15energy coupled proton transport, down electrochemical gradient (GO:0015985)5.08720904
16ribosomal small subunit biogenesis (GO:0042274)5.06126568
17translational initiation (GO:0006413)4.65068364
18protein complex disassembly (GO:0043241)4.52517889
19neuron fate determination (GO:0048664)4.42622570
20ribosomal large subunit biogenesis (GO:0042273)4.42400754
21maturation of SSU-rRNA (GO:0030490)4.33798741
22macromolecular complex disassembly (GO:0032984)4.30380869
23neuronal stem cell maintenance (GO:0097150)4.25646075
24tongue development (GO:0043586)4.13037325
25endocardial cushion morphogenesis (GO:0003203)4.12403513
26chaperone-mediated protein transport (GO:0072321)3.91837374
27protein targeting to membrane (GO:0006612)3.86261977
28spermatid nucleus differentiation (GO:0007289)3.86117578
29nuclear-transcribed mRNA catabolic process (GO:0000956)3.82508793
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.82222161
31respiratory electron transport chain (GO:0022904)3.74901354
32electron transport chain (GO:0022900)3.72980192
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.68590027
34spliceosomal complex assembly (GO:0000245)3.67718216
35mRNA catabolic process (GO:0006402)3.67160546
36CENP-A containing nucleosome assembly (GO:0034080)3.63649729
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.62347080
38chromatin remodeling at centromere (GO:0031055)3.56366921
39lens fiber cell development (GO:0070307)3.53610684
40translation (GO:0006412)3.52566928
41epithelial cilium movement (GO:0003351)3.46409906
42T-helper 1 type immune response (GO:0042088)3.46393719
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46371792
44forebrain neuron differentiation (GO:0021879)3.45231910
45microtubule polymerization or depolymerization (GO:0031109)3.44880242
46detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.43047172
47nonmotile primary cilium assembly (GO:0035058)3.37874832
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30030491
49RNA catabolic process (GO:0006401)3.26660939
50lateral sprouting from an epithelium (GO:0060601)3.18224830
51mesenchyme morphogenesis (GO:0072132)3.15954772
52thalamus development (GO:0021794)3.06919467
53somite development (GO:0061053)3.06703520
54nephron epithelium morphogenesis (GO:0072088)3.04989799
55nephron tubule morphogenesis (GO:0072078)3.04989799
56histone exchange (GO:0043486)3.03628039
57limb bud formation (GO:0060174)3.02366943
58G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.01166898
59regulation of G0 to G1 transition (GO:0070316)3.00268252
60otic vesicle formation (GO:0030916)2.98604697
61midbrain development (GO:0030901)2.96378527
62cilium or flagellum-dependent cell motility (GO:0001539)2.93077728
63regulation of timing of cell differentiation (GO:0048505)2.91698839
64regulation of development, heterochronic (GO:0040034)2.89310322
65kinetochore assembly (GO:0051382)2.89166233
66spinal cord motor neuron differentiation (GO:0021522)2.88886061
67potassium ion export (GO:0071435)2.88740012
68regulation of non-canonical Wnt signaling pathway (GO:2000050)2.87005539
69regulation of phospholipid biosynthetic process (GO:0071071)2.86305067
70notochord development (GO:0030903)2.83486598
71proton transport (GO:0015992)2.77702221
72ATP biosynthetic process (GO:0006754)2.75845389
73hydrogen transport (GO:0006818)2.73834946
74axon ensheathment in central nervous system (GO:0032291)2.73760438
75central nervous system myelination (GO:0022010)2.73760438
76hydrogen ion transmembrane transport (GO:1902600)2.73241713
77cilium movement (GO:0003341)2.66001906
78centriole replication (GO:0007099)2.65755716
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.65347169
80DNA replication-independent nucleosome organization (GO:0034724)2.65245812
81DNA replication-independent nucleosome assembly (GO:0006336)2.65245812
82substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.61012573
83substrate-independent telencephalic tangential migration (GO:0021826)2.61012573
84protein-cofactor linkage (GO:0018065)2.60466576
85cGMP biosynthetic process (GO:0006182)2.60300905
86regulation of appetite (GO:0032098)2.58784589
87epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.57646902
88presynaptic membrane assembly (GO:0097105)2.56917309
89positive regulation of glial cell differentiation (GO:0045687)2.56407082
90presynaptic membrane organization (GO:0097090)2.56163757
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55277109
92signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55277109
93membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.54916330
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.54528924
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.54528924
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.54528924
97sequestering of actin monomers (GO:0042989)2.54361217
98maternal behavior (GO:0042711)2.52907823
99innate immune response in mucosa (GO:0002227)2.50393559
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.49699147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.22567464
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.50385679
3EZH2_22144423_ChIP-Seq_EOC_Human4.32703770
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.25810683
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.82613874
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.53661279
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.24195760
8POU5F1_16153702_ChIP-ChIP_HESCs_Human3.02683822
9VDR_22108803_ChIP-Seq_LS180_Human2.92403202
10TAF15_26573619_Chip-Seq_HEK293_Human2.72049098
11EWS_26573619_Chip-Seq_HEK293_Human2.64967426
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.54027996
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45092985
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.34441710
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33984506
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26946578
17SOX2_16153702_ChIP-ChIP_HESCs_Human2.26777089
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19425652
19RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.11248497
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.10707986
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.01704724
22ELK1_19687146_ChIP-ChIP_HELA_Human2.01174956
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.00802333
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.91986380
25FUS_26573619_Chip-Seq_HEK293_Human1.91769337
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.89841248
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.89841248
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.89841248
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.79640630
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69559613
31POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.69125005
32ZNF274_21170338_ChIP-Seq_K562_Hela1.66884172
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65779931
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64716473
35SOX2_18555785_ChIP-Seq_MESCs_Mouse1.64530105
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.64486903
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55380266
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50722660
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.50160776
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46739920
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42795719
42MYC_18940864_ChIP-ChIP_HL60_Human1.41023712
43NANOG_16153702_ChIP-ChIP_HESCs_Human1.38435800
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36055651
45KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29502178
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29120044
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29027879
48RNF2_27304074_Chip-Seq_NSC_Mouse1.28842625
49P300_19829295_ChIP-Seq_ESCs_Human1.28372739
50VDR_23849224_ChIP-Seq_CD4+_Human1.28027341
51ER_23166858_ChIP-Seq_MCF-7_Human1.28018621
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25129206
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24031275
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24031275
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.21962635
56WDR5_24793694_ChIP-Seq_LNCAP_Human1.19743718
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19616828
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18276396
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17855005
60TTF2_22483619_ChIP-Seq_HELA_Human1.16485230
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14215991
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.11153370
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.10837480
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10194070
65TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09622383
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.08299377
67LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06131775
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05948744
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03689195
70IGF1R_20145208_ChIP-Seq_DFB_Human1.01725342
71TP53_22573176_ChIP-Seq_HFKS_Human1.01193240
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98788402
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98570125
74ELK1_22589737_ChIP-Seq_MCF10A_Human0.98467846
75GBX2_23144817_ChIP-Seq_PC3_Human0.98273264
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97798162
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96130809
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95788684
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95408033
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94313066
81ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93580901
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92475719
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91027743
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90620294
85FOXP3_21729870_ChIP-Seq_TREG_Human0.89554389
86EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89545543
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89400714
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89337476
89BCAT_22108803_ChIP-Seq_LS180_Human0.89201662
90CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.89088406
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86005267
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85926404
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85220154
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83284287
95SUZ12_27294783_Chip-Seq_ESCs_Mouse0.82308415
96CBP_20019798_ChIP-Seq_JUKART_Human0.81805833
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81805833
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.81248968
99SOX2_19829295_ChIP-Seq_ESCs_Human0.80225878
100NANOG_19829295_ChIP-Seq_ESCs_Human0.80225878

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation9.12699557
2MP0003136_yellow_coat_color5.50687809
3MP0000566_synostosis3.28741716
4MP0001485_abnormal_pinna_reflex2.98415789
5MP0003880_abnormal_central_pattern2.94393876
6MP0003878_abnormal_ear_physiology2.65816923
7MP0005377_hearing/vestibular/ear_phenot2.65816923
8MP0010030_abnormal_orbit_morphology2.51136990
9MP0002277_abnormal_respiratory_mucosa2.40126170
10MP0000372_irregular_coat_pigmentation2.25741058
11MP0003283_abnormal_digestive_organ2.03738166
12MP0002282_abnormal_trachea_morphology1.97272449
13MP0002653_abnormal_ependyma_morphology1.86931773
14MP0005174_abnormal_tail_pigmentation1.83633127
15MP0000778_abnormal_nervous_system1.83019395
16MP0002249_abnormal_larynx_morphology1.79862276
17MP0002095_abnormal_skin_pigmentation1.79274339
18MP0002938_white_spotting1.78017778
19MP0000579_abnormal_nail_morphology1.74258183
20MP0006292_abnormal_olfactory_placode1.72810239
21MP0000026_abnormal_inner_ear1.67185542
22MP0008789_abnormal_olfactory_epithelium1.60765161
23MP0005084_abnormal_gallbladder_morpholo1.59841933
24MP0005187_abnormal_penis_morphology1.56638221
25MP0001529_abnormal_vocalization1.54966221
26MP0000631_abnormal_neuroendocrine_gland1.54389790
27MP0004142_abnormal_muscle_tone1.52474015
28MP0002102_abnormal_ear_morphology1.48130018
29MP0005671_abnormal_response_to1.45019358
30MP0006072_abnormal_retinal_apoptosis1.42182929
31MP0003938_abnormal_ear_development1.40272795
32MP0008961_abnormal_basal_metabolism1.40156601
33MP0000762_abnormal_tongue_morphology1.35964500
34MP0001188_hyperpigmentation1.17919999
35MP0005394_taste/olfaction_phenotype1.16526446
36MP0005499_abnormal_olfactory_system1.16526446
37MP0002928_abnormal_bile_duct1.15700256
38MP0002751_abnormal_autonomic_nervous1.13704473
39MP0001346_abnormal_lacrimal_gland1.07624068
40MP0000049_abnormal_middle_ear1.07593903
41MP0001293_anophthalmia1.06884133
42MP0002138_abnormal_hepatobiliary_system1.05432759
43MP0009046_muscle_twitch1.04178474
44MP0004133_heterotaxia1.03482196
45MP0002272_abnormal_nervous_system1.00924918
46MP0000015_abnormal_ear_pigmentation1.00083826
47MP0001286_abnormal_eye_development1.00075875
48MP0008872_abnormal_physiological_respon0.94638943
49MP0000647_abnormal_sebaceous_gland0.94565145
50MP0008875_abnormal_xenobiotic_pharmacok0.94342110
51MP0003755_abnormal_palate_morphology0.93998782
52MP0005645_abnormal_hypothalamus_physiol0.92292383
53MP0001486_abnormal_startle_reflex0.87731629
54MP0000639_abnormal_adrenal_gland0.87065962
55MP0009250_abnormal_appendicular_skeleto0.87010634
56MP0005423_abnormal_somatic_nervous0.86006465
57MP0003567_abnormal_fetal_cardiomyocyte0.85738910
58MP0002067_abnormal_sensory_capabilities0.85611918
59MP0001324_abnormal_eye_pigmentation0.84389692
60MP0001963_abnormal_hearing_physiology0.82429291
61MP0003315_abnormal_perineum_morphology0.82302446
62MP0003121_genomic_imprinting0.82129123
63MP0003122_maternal_imprinting0.80831482
64MP0000462_abnormal_digestive_system0.80417040
65MP0001968_abnormal_touch/_nociception0.79782568
66MP0000749_muscle_degeneration0.79535712
67MP0001663_abnormal_digestive_system0.79433603
68MP0004134_abnormal_chest_morphology0.79153309
69MP0003937_abnormal_limbs/digits/tail_de0.77055297
70MP0005381_digestive/alimentary_phenotyp0.76473084
71MP0005253_abnormal_eye_physiology0.75550282
72MP0003137_abnormal_impulse_conducting0.73452136
73MP0005195_abnormal_posterior_eye0.72198171
74MP0004742_abnormal_vestibular_system0.72111450
75MP0005379_endocrine/exocrine_gland_phen0.71633233
76MP0000490_abnormal_crypts_of0.70629702
77MP0010094_abnormal_chromosome_stability0.69928251
78MP0002064_seizures0.69591651
79MP0002933_joint_inflammation0.69314198
80MP0002876_abnormal_thyroid_physiology0.69085924
81MP0009745_abnormal_behavioral_response0.68339778
82MP0003123_paternal_imprinting0.67520266
83MP0001984_abnormal_olfaction0.67413258
84MP0003806_abnormal_nucleotide_metabolis0.67007283
85MP0002752_abnormal_somatic_nervous0.66304665
86MP0001764_abnormal_homeostasis0.66157309
87MP0002163_abnormal_gland_morphology0.66066915
88MP0002210_abnormal_sex_determination0.65880689
89MP0002697_abnormal_eye_size0.65145401
90MP0002160_abnormal_reproductive_system0.64519347
91MP0002736_abnormal_nociception_after0.64376911
92MP0001905_abnormal_dopamine_level0.64156613
93MP0003077_abnormal_cell_cycle0.63254251
94MP0002234_abnormal_pharynx_morphology0.62113613
95MP0001348_abnormal_lacrimal_gland0.60196833
96MP0003119_abnormal_digestive_system0.58404826
97MP0003787_abnormal_imprinting0.57992378
98MP0002109_abnormal_limb_morphology0.56718485
99MP0001919_abnormal_reproductive_system0.55852969
100MP0005248_abnormal_Harderian_gland0.55553107

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.67510250
2Abnormality of the parietal bone (HP:0002696)4.57782928
3Reticulocytopenia (HP:0001896)4.51977947
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.19533788
5Absent/shortened dynein arms (HP:0200106)4.19533788
6Abnormality of the phalanges of the 2nd finger (HP:0009541)4.08151353
7Rhinitis (HP:0012384)3.66912913
8Partial duplication of the phalanx of hand (HP:0009999)3.59881534
9Maternal diabetes (HP:0009800)3.46338069
10Congenital, generalized hypertrichosis (HP:0004540)3.45731109
11Rib fusion (HP:0000902)3.41214261
12Abnormality of the diencephalon (HP:0010662)3.39180479
13Abnormality of the 2nd finger (HP:0004100)3.34232663
14Abnormal ciliary motility (HP:0012262)3.18929104
15Esophageal atresia (HP:0002032)3.14480624
16Muscle fiber splitting (HP:0003555)3.12591225
17Abnormality of cells of the erythroid lineage (HP:0012130)3.09546937
183-Methylglutaconic aciduria (HP:0003535)3.05417082
19Absent septum pellucidum (HP:0001331)3.03201735
20Increased hepatocellular lipid droplets (HP:0006565)3.00624250
21Macrocytic anemia (HP:0001972)2.98526068
22Chronic sinusitis (HP:0011109)2.86137193
23Chronic otitis media (HP:0000389)2.84511153
24Gastrointestinal atresia (HP:0002589)2.75660330
25Abnormal respiratory motile cilium physiology (HP:0012261)2.74374098
26Respiratory difficulties (HP:0002880)2.70550714
27Supernumerary ribs (HP:0005815)2.70316045
28Abnormal respiratory epithelium morphology (HP:0012253)2.67452849
29Abnormal respiratory motile cilium morphology (HP:0005938)2.67452849
30Lipid accumulation in hepatocytes (HP:0006561)2.64883088
31Supernumerary bones of the axial skeleton (HP:0009144)2.59422270
32Pancreatic cysts (HP:0001737)2.56313950
33Tubular atrophy (HP:0000092)2.54762458
34Depressed nasal tip (HP:0000437)2.50946141
35Abnormal number of erythroid precursors (HP:0012131)2.49687178
36Abnormality of midbrain morphology (HP:0002418)2.49589684
37Molar tooth sign on MRI (HP:0002419)2.49589684
38Partial duplication of thumb phalanx (HP:0009944)2.48055503
39Abnormality of the septum pellucidum (HP:0007375)2.45128786
40Abnormal biliary tract physiology (HP:0012439)2.43437542
41Bile duct proliferation (HP:0001408)2.43437542
42Facial hemangioma (HP:0000329)2.41765972
43Malnutrition (HP:0004395)2.40088107
44Anophthalmia (HP:0000528)2.38477620
45Hyperventilation (HP:0002883)2.36583610
46Renal Fanconi syndrome (HP:0001994)2.36206482
47Optic nerve hypoplasia (HP:0000609)2.29312404
48Mitochondrial inheritance (HP:0001427)2.28551467
49True hermaphroditism (HP:0010459)2.27255644
50Rectovaginal fistula (HP:0000143)2.23401452
51Rectal fistula (HP:0100590)2.23401452
52Colon cancer (HP:0003003)2.22650961
53Hypochromic microcytic anemia (HP:0004840)2.21871018
54Pancreatic fibrosis (HP:0100732)2.16551906
55Missing ribs (HP:0000921)2.16152026
56Hepatic necrosis (HP:0002605)2.11185822
57Hemivertebrae (HP:0002937)2.09605900
58Vertebral fusion (HP:0002948)2.09029162
59Aplasia/Hypoplasia involving the musculature (HP:0001460)2.06283957
60Buphthalmos (HP:0000557)2.04243850
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03624573
62Broad hallux (HP:0010055)2.03096468
63Pallor (HP:0000980)2.00573580
64Intestinal atresia (HP:0011100)1.99783537
65Increased CSF lactate (HP:0002490)1.98629234
66Nephronophthisis (HP:0000090)1.97950027
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96472531
68Abnormality of the middle phalanges of the toes (HP:0010183)1.95954152
69Duplication of thumb phalanx (HP:0009942)1.93843037
70Microvesicular hepatic steatosis (HP:0001414)1.91741824
71Sensory axonal neuropathy (HP:0003390)1.91266993
72Long nose (HP:0003189)1.88213320
73Holoprosencephaly (HP:0001360)1.87281220
7411 pairs of ribs (HP:0000878)1.84845198
75Broad toe (HP:0001837)1.83444475
76Hyporeflexia of lower limbs (HP:0002600)1.82531274
77Hepatocellular necrosis (HP:0001404)1.79910838
78Abnormality of the nasolacrimal system (HP:0000614)1.79559382
79Absent thumb (HP:0009777)1.79276117
80Abnormality of the phalanges of the hallux (HP:0010057)1.78901614
81Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.78223294
82Stenosis of the external auditory canal (HP:0000402)1.77611493
83Ventricular fibrillation (HP:0001663)1.76242853
84Nasolacrimal duct obstruction (HP:0000579)1.75226617
85Confusion (HP:0001289)1.75179464
86Concave nail (HP:0001598)1.73781625
87Intestinal fistula (HP:0100819)1.73353086
88Exertional dyspnea (HP:0002875)1.73102058
89Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72860116
90Vertebral hypoplasia (HP:0008417)1.72860116
91Medial flaring of the eyebrow (HP:0010747)1.72858959
92Humeroradial synostosis (HP:0003041)1.71095975
93Synostosis involving the elbow (HP:0003938)1.71095975
94Respiratory failure (HP:0002878)1.70308851
95Pendular nystagmus (HP:0012043)1.69528116
96Medulloblastoma (HP:0002885)1.68518014
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68441598
98Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68441598
99Abnormality of renal resorption (HP:0011038)1.68326125
100Triphalangeal thumb (HP:0001199)1.66240069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.05845110
2TLK13.82514799
3MAP3K103.35837058
4PNCK3.07765226
5MAP3K123.05624682
6VRK12.75412213
7EPHA32.72308443
8ZAK2.67008042
9NEK12.54063044
10CDC72.44069844
11WNK42.41991156
12WEE12.40280773
13VRK22.38676983
14PKN12.17079089
15NUAK11.90921292
16CDK31.81637982
17MAPK151.81476475
18MAP3K91.80712741
19STK391.69568709
20STK241.46504880
21MAP2K41.44444815
22ARAF1.44050788
23MOS1.41331471
24NEK21.38697300
25STK38L1.37637353
26RPS6KA51.27635121
27FGFR21.26594991
28DAPK31.26366735
29PINK11.25383764
30CDK81.18839353
31EPHA41.08677040
32MAPK71.07651934
33ADRBK21.07503821
34PASK1.04171205
35LATS11.03559630
36LRRK21.02461860
37WNK31.01373853
38SCYL20.97007184
39GRK10.95235038
40MAP2K70.94701413
41AURKA0.94263071
42AURKB0.89859526
43MUSK0.89778874
44UHMK10.89414684
45CSNK1G20.88984642
46RPS6KA40.87616065
47KDR0.85805468
48CDK190.85590394
49PRKG10.84682497
50MKNK10.81848806
51MAP3K40.81556102
52ROCK10.79838252
53DYRK30.78306327
54OXSR10.76556603
55CSNK1G10.76436202
56PAK20.75283838
57CSNK1G30.75263275
58INSRR0.71485769
59MKNK20.71378215
60SRPK10.69420436
61CCNB10.69337437
62CASK0.68874121
63PLK10.67089093
64PLK30.66862329
65DMPK0.62584228
66TRIM280.61606645
67DYRK20.60785544
68CSNK1A1L0.59102655
69BMPR20.58813940
70EPHB20.55257315
71TTK0.55207892
72TAOK30.54539002
73ADRBK10.53429965
74MAP3K130.49336809
75PRKCQ0.46371930
76MARK10.46199113
77ATR0.46010392
78MINK10.43349195
79MAPKAPK20.41847001
80PRKCG0.40704998
81DYRK1B0.39856072
82CSNK2A20.38526712
83TNIK0.38131380
84MELK0.37603017
85OBSCN0.36560540
86CHUK0.36148617
87LYN0.35988955
88STK30.35198377
89CSNK1E0.34274158
90WNK10.34181415
91MYLK0.33567247
92TGFBR10.32512533
93CSNK2A10.31211250
94BRAF0.30745870
95CSF1R0.30113200
96BLK0.29465513
97PHKG10.29414724
98PHKG20.29414724
99PRKCE0.29262118
100MAPK130.26629529

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.86177389
2Oxidative phosphorylation_Homo sapiens_hsa001903.94259828
3Systemic lupus erythematosus_Homo sapiens_hsa053223.77597354
4Parkinsons disease_Homo sapiens_hsa050123.57900952
5Proteasome_Homo sapiens_hsa030503.23559495
6Huntingtons disease_Homo sapiens_hsa050162.85656757
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.61502336
8Asthma_Homo sapiens_hsa053102.60884971
9Alzheimers disease_Homo sapiens_hsa050102.38090670
10Cardiac muscle contraction_Homo sapiens_hsa042602.28088929
11Alcoholism_Homo sapiens_hsa050342.22268959
12Allograft rejection_Homo sapiens_hsa053302.21561744
13Autoimmune thyroid disease_Homo sapiens_hsa053202.15958141
14Protein export_Homo sapiens_hsa030602.10812015
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.06623061
16Graft-versus-host disease_Homo sapiens_hsa053322.03719922
17Type I diabetes mellitus_Homo sapiens_hsa049401.64107055
18Basal cell carcinoma_Homo sapiens_hsa052171.52734386
19RNA degradation_Homo sapiens_hsa030181.48337246
20Homologous recombination_Homo sapiens_hsa034401.46998488
21Fanconi anemia pathway_Homo sapiens_hsa034601.46579840
22RNA polymerase_Homo sapiens_hsa030201.44449212
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.33592259
24Antigen processing and presentation_Homo sapiens_hsa046121.31806304
25Spliceosome_Homo sapiens_hsa030401.31482200
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.30394302
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27945079
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23451931
29Vitamin digestion and absorption_Homo sapiens_hsa049771.06907451
30Viral myocarditis_Homo sapiens_hsa054161.05233812
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04469351
32Nicotine addiction_Homo sapiens_hsa050331.02764883
33Hedgehog signaling pathway_Homo sapiens_hsa043401.02084148
34Folate biosynthesis_Homo sapiens_hsa007900.98455574
35Rheumatoid arthritis_Homo sapiens_hsa053230.97722861
36Primary immunodeficiency_Homo sapiens_hsa053400.95476720
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93803931
38Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92151268
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89411031
40Butanoate metabolism_Homo sapiens_hsa006500.84988281
41Cell cycle_Homo sapiens_hsa041100.84472075
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83813184
43RNA transport_Homo sapiens_hsa030130.82795954
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77925858
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77833265
46Caffeine metabolism_Homo sapiens_hsa002320.72354140
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69054485
48TGF-beta signaling pathway_Homo sapiens_hsa043500.66771577
49Mismatch repair_Homo sapiens_hsa034300.65942252
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.65739593
51Chemical carcinogenesis_Homo sapiens_hsa052040.64835840
52Leishmaniasis_Homo sapiens_hsa051400.61659287
53Staphylococcus aureus infection_Homo sapiens_hsa051500.60950661
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60050760
55Tryptophan metabolism_Homo sapiens_hsa003800.59873844
56Hippo signaling pathway_Homo sapiens_hsa043900.59852094
57DNA replication_Homo sapiens_hsa030300.58718700
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.55707489
59Cocaine addiction_Homo sapiens_hsa050300.54040279
60Sulfur relay system_Homo sapiens_hsa041220.53597721
61Epstein-Barr virus infection_Homo sapiens_hsa051690.52879709
62Wnt signaling pathway_Homo sapiens_hsa043100.51730971
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50617067
64Notch signaling pathway_Homo sapiens_hsa043300.50245021
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49671278
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49457821
67Nitrogen metabolism_Homo sapiens_hsa009100.46359546
68p53 signaling pathway_Homo sapiens_hsa041150.44643931
69Melanogenesis_Homo sapiens_hsa049160.42777534
70Linoleic acid metabolism_Homo sapiens_hsa005910.42225380
71Regulation of autophagy_Homo sapiens_hsa041400.40733497
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39721660
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39020905
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38141074
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.35819646
76Olfactory transduction_Homo sapiens_hsa047400.35334853
77Amphetamine addiction_Homo sapiens_hsa050310.34419692
78Peroxisome_Homo sapiens_hsa041460.34107563
79Phototransduction_Homo sapiens_hsa047440.32070055
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31719511
81Calcium signaling pathway_Homo sapiens_hsa040200.31034721
82Propanoate metabolism_Homo sapiens_hsa006400.28655365
83Taste transduction_Homo sapiens_hsa047420.27647166
84Retinol metabolism_Homo sapiens_hsa008300.26604307
85Dopaminergic synapse_Homo sapiens_hsa047280.26600425
86Serotonergic synapse_Homo sapiens_hsa047260.25479954
87Basal transcription factors_Homo sapiens_hsa030220.24936064
88Axon guidance_Homo sapiens_hsa043600.24524544
89African trypanosomiasis_Homo sapiens_hsa051430.24382375
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23189001
91Circadian entrainment_Homo sapiens_hsa047130.22779250
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19945938
93Oocyte meiosis_Homo sapiens_hsa041140.18772469
94Metabolic pathways_Homo sapiens_hsa011000.18554879
95Viral carcinogenesis_Homo sapiens_hsa052030.18417968
96Tyrosine metabolism_Homo sapiens_hsa003500.17826729
97beta-Alanine metabolism_Homo sapiens_hsa004100.17799834
98Morphine addiction_Homo sapiens_hsa050320.17022912
99mRNA surveillance pathway_Homo sapiens_hsa030150.16740572
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16344274

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