SKAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)8.26064352
2negative thymic T cell selection (GO:0045060)7.81879529
3regulation of isotype switching to IgG isotypes (GO:0048302)7.65926511
4positive regulation of gamma-delta T cell activation (GO:0046645)7.55426024
5positive thymic T cell selection (GO:0045059)7.27593883
6positive T cell selection (GO:0043368)7.13653769
7interferon-gamma production (GO:0032609)7.10482890
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.79505791
9cellular response to interleukin-15 (GO:0071350)6.79084573
10thymic T cell selection (GO:0045061)6.72584445
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.52328738
12negative regulation of cell killing (GO:0031342)6.52328738
13response to interleukin-15 (GO:0070672)6.36914984
14regulation of gamma-delta T cell differentiation (GO:0045586)6.34923232
15T cell selection (GO:0045058)6.27190077
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.10338779
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.10338779
18leukocyte aggregation (GO:0070486)5.74576803
19regulation of gamma-delta T cell activation (GO:0046643)5.74411390
20* T cell receptor signaling pathway (GO:0050852)5.67939325
21regulation of T cell tolerance induction (GO:0002664)5.60558787
22T cell costimulation (GO:0031295)5.54782855
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.52921602
24T cell migration (GO:0072678)5.52493346
25lymphocyte costimulation (GO:0031294)5.51336922
26sequestering of actin monomers (GO:0042989)5.11741209
27antigen processing and presentation of endogenous antigen (GO:0019883)4.98012874
28regulation of T cell receptor signaling pathway (GO:0050856)4.86997362
29* antigen receptor-mediated signaling pathway (GO:0050851)4.62895304
30regulation of B cell receptor signaling pathway (GO:0050855)4.55262582
31positive regulation of tolerance induction (GO:0002645)4.53096989
32regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.48691015
33positive regulation of isotype switching (GO:0045830)4.43444746
34regulation of isotype switching (GO:0045191)4.33605714
35positive regulation of alpha-beta T cell proliferation (GO:0046641)4.33155181
36regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.27369435
37positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.27255946
38positive regulation of natural killer cell mediated immunity (GO:0002717)4.27255946
39regulation of alpha-beta T cell proliferation (GO:0046640)4.25384032
40regulation of natural killer cell mediated immunity (GO:0002715)4.24825709
41regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.24825709
42regulation of interleukin-2 biosynthetic process (GO:0045076)4.18771062
43cytidine deamination (GO:0009972)4.14907205
44cytidine metabolic process (GO:0046087)4.14907205
45cytidine catabolic process (GO:0006216)4.14907205
46positive regulation of T cell mediated cytotoxicity (GO:0001916)4.13250773
47regulation of interferon-gamma-mediated signaling pathway (GO:0060334)4.05939949
48regulation of response to interferon-gamma (GO:0060330)4.05334032
49positive regulation of DNA recombination (GO:0045911)4.01144825
50B cell receptor signaling pathway (GO:0050853)3.98119574
51regulation of B cell differentiation (GO:0045577)3.97686481
52tolerance induction (GO:0002507)3.97049604
53mast cell activation (GO:0045576)3.96811170
54T cell differentiation (GO:0030217)3.94437682
55pyrimidine ribonucleoside catabolic process (GO:0046133)3.92519694
56positive regulation of granulocyte differentiation (GO:0030854)3.91635877
57regulation of tolerance induction (GO:0002643)3.90337058
58regulation of immunoglobulin mediated immune response (GO:0002889)3.88459982
59alpha-beta T cell differentiation (GO:0046632)3.87555134
60activated T cell proliferation (GO:0050798)3.86403367
61positive regulation of interleukin-2 production (GO:0032743)3.85958755
62regulation of defense response to virus by virus (GO:0050690)3.82159250
63positive regulation of B cell mediated immunity (GO:0002714)3.80974041
64positive regulation of immunoglobulin mediated immune response (GO:0002891)3.80974041
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79836700
66positive regulation of B cell differentiation (GO:0045579)3.75697600
67regulation of leukocyte mediated cytotoxicity (GO:0001910)3.75282693
68alpha-beta T cell activation (GO:0046631)3.72750968
69regulation of B cell mediated immunity (GO:0002712)3.72561027
70positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.71924309
71T cell activation (GO:0042110)3.70250994
72regulation of immunoglobulin production (GO:0002637)3.69967434
73regulation of regulatory T cell differentiation (GO:0045589)3.68439718
74regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.65199567
75negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.63570717
76negative regulation of T cell receptor signaling pathway (GO:0050860)3.62639810
77positive regulation of immunoglobulin production (GO:0002639)3.61940204
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.56736681
79regulation of cell killing (GO:0031341)3.56175170
80alpha-beta T cell differentiation involved in immune response (GO:0002293)3.53166947
81alpha-beta T cell activation involved in immune response (GO:0002287)3.53166947
82T cell differentiation involved in immune response (GO:0002292)3.53166947
83positive regulation of cell killing (GO:0031343)3.52578569
84negative regulation of leukocyte mediated immunity (GO:0002704)3.49076475
85natural killer cell activation (GO:0030101)3.48299716
86CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.42861275
87T-helper cell differentiation (GO:0042093)3.42861275
88regulation of interleukin-12 biosynthetic process (GO:0045075)3.41951514
89regulation of type I interferon-mediated signaling pathway (GO:0060338)3.40417734
90DNA deamination (GO:0045006)3.40121082
91negative regulation of T cell mediated immunity (GO:0002710)3.37772610
92immunoglobulin mediated immune response (GO:0016064)3.37653786
93negative regulation of lymphocyte mediated immunity (GO:0002707)3.37510515
94regulation of interleukin-4 production (GO:0032673)3.28776317
95positive regulation of humoral immune response (GO:0002922)3.28045119
96leukocyte cell-cell adhesion (GO:0007159)3.26674052
97NIK/NF-kappaB signaling (GO:0038061)3.22588073
98neutrophil activation (GO:0042119)3.18029123
99lymphocyte migration (GO:0072676)3.16401257
100Arp2/3 complex-mediated actin nucleation (GO:0034314)3.16221044
101regulation of lymphocyte mediated immunity (GO:0002706)3.15897378
102positive regulation of T cell mediated immunity (GO:0002711)3.14867598
103positive regulation of T cell activation (GO:0050870)3.14594156
104signal peptide processing (GO:0006465)3.12546136
105V(D)J recombination (GO:0033151)3.11660497
106regulation of T cell mediated cytotoxicity (GO:0001914)3.10898495
107antigen processing and presentation via MHC class Ib (GO:0002475)3.10752264
108* immune response-activating cell surface receptor signaling pathway (GO:0002429)3.09422117
109positive regulation of lamellipodium assembly (GO:0010592)3.09086395
110regulation of T cell mediated immunity (GO:0002709)3.08662793
111positive regulation of defense response to virus by host (GO:0002230)3.08472024
112positive regulation of interleukin-4 production (GO:0032753)3.08076037
113detection of bacterium (GO:0016045)3.07982812
114T cell homeostasis (GO:0043029)3.07960277
115response to type I interferon (GO:0034340)3.07953446
116regulation of alpha-beta T cell activation (GO:0046634)3.07420291
117granulocyte activation (GO:0036230)3.06719080
118positive regulation of lymphocyte mediated immunity (GO:0002708)3.05026668
119negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04419849
120heterotypic cell-cell adhesion (GO:0034113)3.04329736
121cellular response to type I interferon (GO:0071357)3.04288388
122type I interferon signaling pathway (GO:0060337)3.04288388
123dendritic cell chemotaxis (GO:0002407)3.01900124
124regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00930540
125negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.99832330
126positive regulation of calcium-mediated signaling (GO:0050850)2.99753202
127mucosal-associated lymphoid tissue development (GO:0048537)2.99147458
128Peyers patch development (GO:0048541)2.99147458
129cellular defense response (GO:0006968)2.97489354
130B cell mediated immunity (GO:0019724)2.97266661
131neutrophil activation involved in immune response (GO:0002283)2.93950392
132regulation of antigen processing and presentation (GO:0002577)2.93295804
133negative regulation of T cell apoptotic process (GO:0070233)2.93063803
134natural killer cell differentiation (GO:0001779)2.92037855
135detection of other organism (GO:0098543)2.90081156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.37956771
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.16662490
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.32596527
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.15872763
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.78305297
6STAT4_19710469_ChIP-ChIP_TH1__Mouse3.63209025
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.61708050
8* RUNX_20019798_ChIP-Seq_JUKART_Human3.60503384
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.60139315
10* MYB_26560356_Chip-Seq_TH2_Human3.38051050
11MYC_22102868_ChIP-Seq_BL_Human3.10070293
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.06934900
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94271456
14MAF_26560356_Chip-Seq_TH1_Human2.85039928
15UTX_26944678_Chip-Seq_JUKART_Human2.78095450
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73533875
17* MYB_26560356_Chip-Seq_TH1_Human2.71793152
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.51311950
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.50145664
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.50036649
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.49758095
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38709239
23E2F7_22180533_ChIP-Seq_HELA_Human2.30455493
24GATA3_27048872_Chip-Seq_THYMUS_Human2.26069995
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.26048751
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.22145617
27MAF_26560356_Chip-Seq_TH2_Human2.06899944
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93642439
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.92167450
30SPI1_23547873_ChIP-Seq_NB4_Human1.91469858
31VDR_23849224_ChIP-Seq_CD4+_Human1.75437652
32* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73969327
33GABP_17652178_ChIP-ChIP_JURKAT_Human1.69183514
34FOXP3_21729870_ChIP-Seq_TREG_Human1.65314477
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.64097206
36SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62926828
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62304805
38RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.56423742
39VDR_21846776_ChIP-Seq_THP-1_Human1.55129203
40DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.54217816
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52091467
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46365325
43CIITA_25753668_ChIP-Seq_RAJI_Human1.44678939
44* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43593660
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42627779
46TCF7_22412390_ChIP-Seq_EML_Mouse1.41517053
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40879156
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39936803
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.37406052
50GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.35760810
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.34355101
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.33817126
53* GATA3_26560356_Chip-Seq_TH2_Human1.32275845
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.31697386
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31175861
56IRF8_27001747_Chip-Seq_BMDM_Mouse1.30956794
57* SPI1_23127762_ChIP-Seq_K562_Human1.25009306
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23180643
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23127598
60BCL6_27268052_Chip-Seq_Bcells_Human1.22712614
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21238491
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20257570
63VDR_24763502_ChIP-Seq_THP-1_Human1.19892702
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19653341
65SCL_19346495_ChIP-Seq_HPC-7_Human1.18671111
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15508945
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14800648
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14619873
69* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.13247100
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.12467623
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08815141
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08557479
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07387646
74ELK1_19687146_ChIP-ChIP_HELA_Human1.06585005
75KDM2B_26808549_Chip-Seq_DND41_Human1.04750582
76CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03700916
77VDR_24787735_ChIP-Seq_THP-1_Human1.02727603
78VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02549260
79PU_27001747_Chip-Seq_BMDM_Mouse1.02434367
80GATA3_26560356_Chip-Seq_TH1_Human1.02108627
81GATA1_22025678_ChIP-Seq_K562_Human1.01852078
82* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01384556
83BCOR_27268052_Chip-Seq_Bcells_Human1.01229630
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.00617554
85P300_27268052_Chip-Seq_Bcells_Human1.00486847
86BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00309158
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00147424
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99640941
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98559663
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98399426
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94459558
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94442897
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94246311
94GABP_19822575_ChIP-Seq_HepG2_Human0.89584863
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89030975
96TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88513231
97E2F4_17652178_ChIP-ChIP_JURKAT_Human0.88488089
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87660548
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.86518921
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.85620300
101SMRT_27268052_Chip-Seq_Bcells_Human0.85217104
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84922374
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83543147
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83169732
105RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82919869
106KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82901222
107KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82897273
108SPI1_20517297_ChIP-Seq_HL60_Human0.82782162
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81401247
110Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79522504
111RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79422405
112STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77980490
113* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77587302
114ETS1_20019798_ChIP-Seq_JURKAT_Human0.76269456
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76239177
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.75764515
117SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.75532859
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73742007
119XRN2_22483619_ChIP-Seq_HELA_Human0.73242495
120PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73231422
121TP63_19390658_ChIP-ChIP_HaCaT_Human0.73030987
122* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72873568
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72024685
124FLI1_21867929_ChIP-Seq_CD8_Mouse0.71779966
125PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.70541628
126KDM5A_27292631_Chip-Seq_BREAST_Human0.69916279
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.68051373
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.67601103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.40984696
2MP0005671_abnormal_response_to5.71144845
3MP0001835_abnormal_antigen_presentation3.42364377
4MP0000685_abnormal_immune_system3.41582307
5MP0002166_altered_tumor_susceptibility3.30066028
6MP0001800_abnormal_humoral_immune3.10525563
7MP0009333_abnormal_splenocyte_physiolog3.10360448
8MP0005000_abnormal_immune_tolerance2.91460851
9MP0000703_abnormal_thymus_morphology2.90724612
10* MP0002420_abnormal_adaptive_immunity2.86516148
11* MP0001819_abnormal_immune_cell2.83168860
12MP0006082_CNS_inflammation2.83058559
13MP0002006_tumorigenesis2.82403060
14* MP0002398_abnormal_bone_marrow2.81394844
15MP0009785_altered_susceptibility_to2.81219937
16* MP0002723_abnormal_immune_serum2.77555787
17* MP0005387_immune_system_phenotype2.56926599
18* MP0001790_abnormal_immune_system2.56926599
19MP0002405_respiratory_system_inflammati2.55017721
20* MP0000716_abnormal_immune_system2.46609852
21MP0002452_abnormal_antigen_presenting2.45635928
22MP0005025_abnormal_response_to2.38796453
23MP0002722_abnormal_immune_system2.36701342
24MP0003724_increased_susceptibility_to2.35783427
25MP0001873_stomach_inflammation2.22261778
26MP0002933_joint_inflammation2.17774012
27MP0000689_abnormal_spleen_morphology2.15843353
28MP0010155_abnormal_intestine_physiology2.09986485
29MP0004947_skin_inflammation2.06519580
30MP0005310_abnormal_salivary_gland2.06280685
31MP0003866_abnormal_defecation2.05668652
32* MP0002429_abnormal_blood_cell1.96877815
33MP0003436_decreased_susceptibility_to1.91597366
34MP0004381_abnormal_hair_follicle1.76772366
35MP0002396_abnormal_hematopoietic_system1.75202342
36MP0003303_peritoneal_inflammation1.72832710
37MP0003300_gastrointestinal_ulcer1.71513252
38MP0002148_abnormal_hypersensitivity_rea1.68348824
39MP0001845_abnormal_inflammatory_respons1.66064767
40MP0002419_abnormal_innate_immunity1.57707551
41MP0002693_abnormal_pancreas_physiology1.54248335
42MP0000858_altered_metastatic_potential1.53430272
43MP0005075_abnormal_melanosome_morpholog1.51859192
44MP0004510_myositis1.46721554
45MP0002009_preneoplasia1.35693019
46MP0002132_abnormal_respiratory_system1.34152879
47MP0005464_abnormal_platelet_physiology1.31109090
48MP0002877_abnormal_melanocyte_morpholog1.20522896
49MP0008469_abnormal_protein_level1.05698872
50MP0001986_abnormal_taste_sensitivity1.05219995
51MP0002019_abnormal_tumor_incidence1.04894538
52MP0003183_abnormal_peptide_metabolism1.04005325
53MP0003448_altered_tumor_morphology1.03549700
54MP0000490_abnormal_crypts_of1.03135346
55MP0002138_abnormal_hepatobiliary_system0.99712061
56MP0008961_abnormal_basal_metabolism0.99383539
57MP0002909_abnormal_adrenal_gland0.98633021
58MP0001533_abnormal_skeleton_physiology0.96156455
59MP0005645_abnormal_hypothalamus_physiol0.93795513
60MP0003045_fibrosis0.92306339
61MP0004808_abnormal_hematopoietic_stem0.91318386
62MP0001853_heart_inflammation0.88368006
63MP0001944_abnormal_pancreas_morphology0.86288634
64MP0001851_eye_inflammation0.85175631
65MP0003693_abnormal_embryo_hatching0.84516854
66MP0002998_abnormal_bone_remodeling0.84198641
67MP0002163_abnormal_gland_morphology0.83408138
68MP0005379_endocrine/exocrine_gland_phen0.74706715
69MP0000613_abnormal_salivary_gland0.74079592
70MP0001663_abnormal_digestive_system0.72818258
71MP0004957_abnormal_blastocyst_morpholog0.70935677
72MP0002928_abnormal_bile_duct0.70444040
73MP0008057_abnormal_DNA_replication0.70170960
74MP0000013_abnormal_adipose_tissue0.68525710
75MP0003795_abnormal_bone_structure0.66937785
76MP0000465_gastrointestinal_hemorrhage0.66347920
77MP0009765_abnormal_xenobiotic_induced0.65803549
78MP0003787_abnormal_imprinting0.64642887
79MP0009763_increased_sensitivity_to0.62073978
80MP0000569_abnormal_digit_pigmentation0.61064088
81MP0003806_abnormal_nucleotide_metabolis0.60842659
82MP0001348_abnormal_lacrimal_gland0.58886315
83MP0003172_abnormal_lysosome_physiology0.58531571
84MP0008877_abnormal_DNA_methylation0.58117020
85MP0008058_abnormal_DNA_repair0.56737654
86MP0003077_abnormal_cell_cycle0.56720814
87MP0000372_irregular_coat_pigmentation0.56464457
88MP0000477_abnormal_intestine_morphology0.56440954
89MP0008872_abnormal_physiological_respon0.55534708
90MP0000015_abnormal_ear_pigmentation0.55125765
91MP0000249_abnormal_blood_vessel0.54873662
92MP0004883_abnormal_blood_vessel0.54420328
93MP0001243_abnormal_dermal_layer0.54160527
94MP0005166_decreased_susceptibility_to0.53357674
95MP0008007_abnormal_cellular_replicative0.52645755
96MP0008873_increased_physiological_sensi0.52618481
97MP0003252_abnormal_bile_duct0.51918666
98MP0005390_skeleton_phenotype0.51911670
99MP0000678_abnormal_parathyroid_gland0.51716521
100MP0003786_premature_aging0.51500716
101MP0003646_muscle_fatigue0.51384849
102MP0006072_abnormal_retinal_apoptosis0.50691150
103MP0001765_abnormal_ion_homeostasis0.50348090
104MP0002876_abnormal_thyroid_physiology0.50221713
105MP0008260_abnormal_autophagy0.49970741
106MP0002277_abnormal_respiratory_mucosa0.47587349
107MP0001919_abnormal_reproductive_system0.46573597
108MP0006292_abnormal_olfactory_placode0.46274359
109MP0004130_abnormal_muscle_cell0.46191909
110MP0009643_abnormal_urine_homeostasis0.45936827
111MP0000609_abnormal_liver_physiology0.45710410
112MP0000313_abnormal_cell_death0.45709376
113MP0002136_abnormal_kidney_physiology0.45245282
114MP0005023_abnormal_wound_healing0.44437427
115MP0005220_abnormal_exocrine_pancreas0.44197518
116MP0002095_abnormal_skin_pigmentation0.42823229
117MP0003191_abnormal_cellular_cholesterol0.42576740
118MP0010386_abnormal_urinary_bladder0.42173995
119MP0003959_abnormal_lean_body0.42019486
120MP0005451_abnormal_body_composition0.40701587
121MP0009764_decreased_sensitivity_to0.40641339
122MP0009278_abnormal_bone_marrow0.40498869
123MP0008874_decreased_physiological_sensi0.40261888
124MP0000604_amyloidosis0.40137560
125MP0005174_abnormal_tail_pigmentation0.40134272
126MP0010094_abnormal_chromosome_stability0.40086663
127MP0003075_altered_response_to0.39910875
128MP0009642_abnormal_blood_homeostasis0.39878753

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)8.71102814
2Abnormality of T cell number (HP:0011839)8.33132366
3Severe combined immunodeficiency (HP:0004430)7.38456122
4Combined immunodeficiency (HP:0005387)6.98197288
5Abnormality of T cells (HP:0002843)6.01442730
6Elevated erythrocyte sedimentation rate (HP:0003565)5.68637159
7Recurrent bronchitis (HP:0002837)5.52359893
8IgG deficiency (HP:0004315)5.20865900
9Hypoplasia of the thymus (HP:0000778)4.92434655
10Stomatitis (HP:0010280)4.73557610
11Thyroiditis (HP:0100646)4.70289957
12Recurrent cutaneous fungal infections (HP:0011370)4.62539485
13Chronic mucocutaneous candidiasis (HP:0002728)4.62539485
14Increased IgM level (HP:0003496)4.50232010
15IgM deficiency (HP:0002850)4.37815188
16Autoimmune hemolytic anemia (HP:0001890)4.37755595
17Abnormality of eosinophils (HP:0001879)4.37450959
18Recurrent fungal infections (HP:0002841)4.36930058
19Chronic diarrhea (HP:0002028)4.36543051
20Panhypogammaglobulinemia (HP:0003139)4.30646634
21Nasal polyposis (HP:0100582)4.19022883
22Abnormality of B cell number (HP:0010975)4.09358869
23B lymphocytopenia (HP:0010976)4.09358869
24Recurrent bacterial skin infections (HP:0005406)3.87694863
25Abnormality of T cell physiology (HP:0011840)3.82682367
26Myositis (HP:0100614)3.75371906
27Recurrent viral infections (HP:0004429)3.63601113
28Bronchitis (HP:0012387)3.56702917
29Chronic otitis media (HP:0000389)3.56428820
30Abnormal delayed hypersensitivity skin test (HP:0002963)3.56397383
31Lymphopenia (HP:0001888)3.54363029
32Eczematoid dermatitis (HP:0000976)3.48432235
33Eosinophilia (HP:0001880)3.47503716
34Leukocytosis (HP:0001974)3.41305147
35Abnormality of the nasal mucosa (HP:0000433)3.39159231
36Joint swelling (HP:0001386)3.39020868
37Abnormality of cells of the lymphoid lineage (HP:0012140)3.37896309
38Abnormality of macrophages (HP:0004311)3.33346817
39Abnormality of the fingertips (HP:0001211)3.18690686
40Granulocytopenia (HP:0001913)3.05340852
41Optic neuritis (HP:0100653)3.00575403
42Retrobulbar optic neuritis (HP:0100654)3.00575403
43Papilloma (HP:0012740)2.96696498
44Verrucae (HP:0200043)2.96696498
45Gastrointestinal stroma tumor (HP:0100723)2.84828806
46Recurrent gram-negative bacterial infections (HP:0005420)2.77418316
47Recurrent sinusitis (HP:0011108)2.75944980
48Meningitis (HP:0001287)2.74927337
49Lymphoma (HP:0002665)2.74920346
50Pustule (HP:0200039)2.74832658
51Hemoptysis (HP:0002105)2.73588650
52Hypergammaglobulinemia (HP:0010702)2.70337239
53Colitis (HP:0002583)2.68982218
54Agammaglobulinemia (HP:0004432)2.63463320
55Orchitis (HP:0100796)2.63387697
56Pulmonary infiltrates (HP:0002113)2.55004978
57Encephalitis (HP:0002383)2.48814008
58Cellulitis (HP:0100658)2.43799813
59Cheilitis (HP:0100825)2.43783371
60Prolonged bleeding time (HP:0003010)2.42615249
61Vasculitis (HP:0002633)2.39776706
62Recurrent skin infections (HP:0001581)2.38540788
63Gastrointestinal infarctions (HP:0005244)2.38509582
64Urticaria (HP:0001025)2.35090147
65IgA deficiency (HP:0002720)2.32246971
66Recurrent otitis media (HP:0000403)2.32085260
67Abnormality of the pleura (HP:0002103)2.27884940
68Bronchiectasis (HP:0002110)2.25488244
69Hypochromic anemia (HP:0001931)2.24044456
70Skin rash (HP:0000988)2.23399173
71Aplasia/Hypoplasia of the thymus (HP:0010515)2.20084330
72Prostate neoplasm (HP:0100787)2.17353316
73Amyotrophic lateral sclerosis (HP:0007354)2.17089168
74Recurrent abscess formation (HP:0002722)2.15298935
75Reduced subcutaneous adipose tissue (HP:0003758)2.14783218
76Chronic obstructive pulmonary disease (HP:0006510)2.12890522
77Obstructive lung disease (HP:0006536)2.12890522
78Autoimmune thrombocytopenia (HP:0001973)2.11795468
79Basal cell carcinoma (HP:0002671)2.08738640
80Sepsis (HP:0100806)2.07737835
81Keratoconjunctivitis sicca (HP:0001097)2.05018656
82Stomach cancer (HP:0012126)2.03638118
83Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.02169352
84Neutropenia (HP:0001875)2.00415193
85Glomerulopathy (HP:0100820)1.96436552
86Gingival bleeding (HP:0000225)1.96325539
87Osteomyelitis (HP:0002754)1.96230356
88Recurrent pneumonia (HP:0006532)1.95681532
89Aplastic anemia (HP:0001915)1.94971910
90Recurrent lower respiratory tract infections (HP:0002783)1.93060603
91Chronic sinusitis (HP:0011109)1.92166350
92Congenital stationary night blindness (HP:0007642)1.91861493
93Mediastinal lymphadenopathy (HP:0100721)1.86746985
94Microcytic anemia (HP:0001935)1.86003028
95Gingivitis (HP:0000230)1.85815454
96Renal cortical cysts (HP:0000803)1.84829505
97Keratoconjunctivitis (HP:0001096)1.82558459
98Spontaneous hematomas (HP:0007420)1.81315718
99Hypoproteinemia (HP:0003075)1.78140837
100Inflammation of the large intestine (HP:0002037)1.75992292
101Ureteral stenosis (HP:0000071)1.74778568
102Anorexia (HP:0002039)1.73344979
103Gastrointestinal inflammation (HP:0004386)1.72835710
104Abnormality of the endocardium (HP:0004306)1.71029493
105Entropion (HP:0000621)1.70484513
106Ureteral obstruction (HP:0006000)1.67345502
107Poikiloderma (HP:0001029)1.65916081
108Menstrual irregularities (HP:0000858)1.65575414
109Keratitis (HP:0000491)1.65214720
110Increased IgE level (HP:0003212)1.64930929
111Abnormality of the prostate (HP:0008775)1.64532429
112Gangrene (HP:0100758)1.62899999
113Abnormality of the thymus (HP:0000777)1.60485499
114Arterial thrombosis (HP:0004420)1.59251444
115Muscle fiber atrophy (HP:0100295)1.57627723
116Epistaxis (HP:0000421)1.57353686
117Cellular immunodeficiency (HP:0005374)1.56155428
118Prominent metopic ridge (HP:0005487)1.54811506
119Chest pain (HP:0100749)1.54748429
120Type 2 muscle fiber atrophy (HP:0003554)1.54268361
121Polyneuropathy (HP:0001271)1.54162578
122Pulmonary embolism (HP:0002204)1.53667415
123Acute hepatic failure (HP:0006554)1.52816622
124Petechiae (HP:0000967)1.52033512

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.05611876
2MAP4K15.56514001
3ZAP703.90902578
4ITK3.43398097
5JAK33.12889592
6FGFR43.06085910
7KDR3.02877166
8RIPK43.00010813
9IKBKE2.89477893
10NLK2.47796465
11TESK22.21761728
12STK102.11287812
13TYK22.09853252
14GRK62.07972018
15LCK2.02528153
16MAP3K121.93856028
17JAK11.92183299
18FGFR31.87276016
19TEC1.77855710
20CSK1.67308393
21PASK1.60045173
22NME21.58421447
23SYK1.48646882
24MST41.48130164
25TBK11.47130961
26MAP3K141.42257851
27BLK1.32442118
28PRKCH1.28820754
29BTK1.25861645
30MAP3K111.21640457
31IRAK41.20346511
32MAP4K21.12288488
33PRKCQ1.12050166
34HCK1.05830869
35PRPF4B1.05531676
36HIPK21.04529164
37MAP3K130.97202274
38TNK20.95681236
39CAMKK20.89962382
40PRKD20.84742182
41TAOK30.82727750
42CAMKK10.82510745
43TGFBR20.80844822
44IKBKB0.80805756
45LYN0.77931392
46IRAK10.76146167
47EPHB10.75323432
48TESK10.75306713
49KIT0.74251567
50SIK30.74214330
51ADRBK20.72066600
52FLT30.70978157
53MARK30.70930315
54RIPK10.68415199
55MAPK150.68361962
56FGR0.67633432
57CHUK0.67411236
58MAP2K20.65975824
59JAK20.64806570
60MAP3K100.63510083
61CLK10.62238593
62TLK10.62123044
63RPS6KA40.60966127
64MAP2K30.59923437
65GRK70.58735274
66INSRR0.58442967
67MAPK110.56648420
68EPHA30.55654224
69SCYL20.54621829
70INSR0.53136057
71MARK20.52999784
72PDGFRB0.52289066
73GRK10.52070803
74PIM10.50981519
75MAP3K10.49835734
76ZAK0.48778162
77LRRK20.46770483
78FGFR10.45782037
79CDK190.45720859
80NUAK10.45554087
81IGF1R0.42292692
82SIK20.42255503
83MAPK120.41715989
84IRAK20.40456403
85MAPKAPK30.39895862
86ACVR1B0.39620679
87CDK120.39179032
88MAPKAPK20.37842281
89MAP3K30.37115444
90MAPK70.36369956
91BMPR20.35552591
92MATK0.35065625
93MYLK0.32533297
94DAPK10.31533839
95MAP2K60.30132363
96PIK3CA0.29162861
97MAPK30.28849745
98CDK90.28263454
99* FYN0.28226968
100PDK10.27610591
101MAP3K70.26172534
102MELK0.25404701
103PDPK10.25222136
104BCKDK0.24323803
105PTK60.23527062
106TAOK20.23062713
107IRAK30.22984632
108EIF2AK30.22941296
109DYRK1B0.21942579
110ERN10.21622225
111PRKD30.21443951
112BRD40.21282219
113ILK0.20592856
114PKN20.20439799
115EEF2K0.19754552
116ABL10.19274249
117SRPK10.19049453
118PRKCD0.18477766
119TYRO30.18096692
120STK40.18056545
121RPS6KA60.16950025
122CSF1R0.16741517
123CDC70.16263690
124TAOK10.16217839
125FES0.15244840
126STK160.15194996
127PIK3CG0.14931156
128RPS6KA50.14421336
129PTK20.13741695
130CDK40.13302668
131CSNK1G10.13183937

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.28386666
2T cell receptor signaling pathway_Homo sapiens_hsa046604.02761070
3Graft-versus-host disease_Homo sapiens_hsa053323.46431325
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046503.40618441
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.21197902
6Allograft rejection_Homo sapiens_hsa053302.97534269
7Antigen processing and presentation_Homo sapiens_hsa046122.90036260
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.83951395
9Measles_Homo sapiens_hsa051622.80339994
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.36108852
11Hematopoietic cell lineage_Homo sapiens_hsa046402.30477583
12Autoimmune thyroid disease_Homo sapiens_hsa053202.18587535
13Protein export_Homo sapiens_hsa030602.17909087
14Staphylococcus aureus infection_Homo sapiens_hsa051501.89053578
15Type I diabetes mellitus_Homo sapiens_hsa049401.73930376
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.71810560
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65067575
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.62877720
19Viral myocarditis_Homo sapiens_hsa054161.58998062
20Leishmaniasis_Homo sapiens_hsa051401.52670846
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43675322
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43650177
23Osteoclast differentiation_Homo sapiens_hsa043801.40588633
24Non-homologous end-joining_Homo sapiens_hsa034501.33725115
25Herpes simplex infection_Homo sapiens_hsa051681.32059243
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21293352
27Asthma_Homo sapiens_hsa053101.18313719
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11971427
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11262677
30Chemokine signaling pathway_Homo sapiens_hsa040621.08711069
31HTLV-I infection_Homo sapiens_hsa051661.00431004
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98417649
33Leukocyte transendothelial migration_Homo sapiens_hsa046700.98009561
34B cell receptor signaling pathway_Homo sapiens_hsa046620.97522177
35Other glycan degradation_Homo sapiens_hsa005110.97159088
36Hepatitis B_Homo sapiens_hsa051610.93992564
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90325633
38Shigellosis_Homo sapiens_hsa051310.89508169
39Proteasome_Homo sapiens_hsa030500.87627615
40Toxoplasmosis_Homo sapiens_hsa051450.86621923
41Prolactin signaling pathway_Homo sapiens_hsa049170.86037534
42Acute myeloid leukemia_Homo sapiens_hsa052210.85748829
43Pancreatic cancer_Homo sapiens_hsa052120.84107676
44RNA degradation_Homo sapiens_hsa030180.83758414
45Colorectal cancer_Homo sapiens_hsa052100.82563956
46NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78255982
47Ribosome_Homo sapiens_hsa030100.76427682
48African trypanosomiasis_Homo sapiens_hsa051430.75309806
49Influenza A_Homo sapiens_hsa051640.74956482
50Spliceosome_Homo sapiens_hsa030400.73974627
51Apoptosis_Homo sapiens_hsa042100.73205476
52TNF signaling pathway_Homo sapiens_hsa046680.71772414
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71529971
54Non-small cell lung cancer_Homo sapiens_hsa052230.70065527
55p53 signaling pathway_Homo sapiens_hsa041150.69035256
56Systemic lupus erythematosus_Homo sapiens_hsa053220.64695510
57Viral carcinogenesis_Homo sapiens_hsa052030.62169733
58Thyroid cancer_Homo sapiens_hsa052160.60929618
59Epstein-Barr virus infection_Homo sapiens_hsa051690.60267205
60Legionellosis_Homo sapiens_hsa051340.60188465
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59007438
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57928917
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53664416
64Nucleotide excision repair_Homo sapiens_hsa034200.53463344
65Pertussis_Homo sapiens_hsa051330.51378829
66VEGF signaling pathway_Homo sapiens_hsa043700.50986204
67Rheumatoid arthritis_Homo sapiens_hsa053230.50379857
68Basal transcription factors_Homo sapiens_hsa030220.50312724
69Hepatitis C_Homo sapiens_hsa051600.48208542
70Mismatch repair_Homo sapiens_hsa034300.47283988
71Malaria_Homo sapiens_hsa051440.47185199
72Regulation of autophagy_Homo sapiens_hsa041400.47024648
73RNA polymerase_Homo sapiens_hsa030200.46103294
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43474363
75Platelet activation_Homo sapiens_hsa046110.42956562
76Endocytosis_Homo sapiens_hsa041440.40614820
77Base excision repair_Homo sapiens_hsa034100.40371405
78Tuberculosis_Homo sapiens_hsa051520.40295553
79Phagosome_Homo sapiens_hsa041450.38828342
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38717259
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38509024
82mRNA surveillance pathway_Homo sapiens_hsa030150.38041057
83Homologous recombination_Homo sapiens_hsa034400.37737286
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37458476
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.37216227
86Linoleic acid metabolism_Homo sapiens_hsa005910.37113473
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36972340
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36744127
89Salmonella infection_Homo sapiens_hsa051320.36245455
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35226971
91DNA replication_Homo sapiens_hsa030300.33448925
92Chronic myeloid leukemia_Homo sapiens_hsa052200.33151003
93Phototransduction_Homo sapiens_hsa047440.32236378
94Lysosome_Homo sapiens_hsa041420.31191068
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30482546
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30263220
97FoxO signaling pathway_Homo sapiens_hsa040680.29829132
98Inositol phosphate metabolism_Homo sapiens_hsa005620.29037424
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28459695
100Cell cycle_Homo sapiens_hsa041100.28176804
101Insulin resistance_Homo sapiens_hsa049310.27940709
102MAPK signaling pathway_Homo sapiens_hsa040100.26810566
103Pyrimidine metabolism_Homo sapiens_hsa002400.25137498
104Arachidonic acid metabolism_Homo sapiens_hsa005900.24769290
105Caffeine metabolism_Homo sapiens_hsa002320.24263857
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23956578
107Type II diabetes mellitus_Homo sapiens_hsa049300.21782084
108Choline metabolism in cancer_Homo sapiens_hsa052310.21586664
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.21435682
110N-Glycan biosynthesis_Homo sapiens_hsa005100.21260969
111Notch signaling pathway_Homo sapiens_hsa043300.20858010
112Insulin secretion_Homo sapiens_hsa049110.20594379
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20426844
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19648992
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.19247578
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.18135744
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18122425
118Endometrial cancer_Homo sapiens_hsa052130.17738247
119Olfactory transduction_Homo sapiens_hsa047400.16275243
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14576073
121Ras signaling pathway_Homo sapiens_hsa040140.12136840
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11232376
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10132685
124ABC transporters_Homo sapiens_hsa020100.09904475
125Ether lipid metabolism_Homo sapiens_hsa005650.08608977
126Dorso-ventral axis formation_Homo sapiens_hsa043200.08597905
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.07649676
128mTOR signaling pathway_Homo sapiens_hsa041500.07235452
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.05737502

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