SKAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.69516637
2daunorubicin metabolic process (GO:0044597)5.19183958
3polyketide metabolic process (GO:0030638)5.19183958
4doxorubicin metabolic process (GO:0044598)5.19183958
5response to peptidoglycan (GO:0032494)4.89492297
6neutrophil activation involved in immune response (GO:0002283)4.88998333
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.75086375
8negative regulation of cell killing (GO:0031342)4.75086375
9immunoglobulin mediated immune response (GO:0016064)4.66069868
10positive regulation of mast cell activation (GO:0033005)4.21636379
11positive regulation by symbiont of host defense response (GO:0052509)4.10256169
12modulation by symbiont of host defense response (GO:0052031)4.10256169
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.10256169
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.10256169
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.10256169
16modulation by symbiont of host immune response (GO:0052553)4.10256169
17B cell mediated immunity (GO:0019724)3.80437190
18positive regulation of mast cell activation involved in immune response (GO:0033008)3.78784354
19positive regulation of mast cell degranulation (GO:0043306)3.78784354
20detection of molecule of bacterial origin (GO:0032490)3.72622235
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.71298052
22detection of bacterium (GO:0016045)3.67382888
23regulation of mast cell activation involved in immune response (GO:0033006)3.62434756
24positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.59800341
25respiratory burst (GO:0045730)3.59199352
26neutrophil activation (GO:0042119)3.57557609
27natural killer cell mediated cytotoxicity (GO:0042267)3.56480248
28natural killer cell mediated immunity (GO:0002228)3.56480248
29detection of external biotic stimulus (GO:0098581)3.56412439
30positive regulation of interferon-alpha production (GO:0032727)3.56021905
31regulation of interferon-beta biosynthetic process (GO:0045357)3.55389021
32granulocyte activation (GO:0036230)3.50272676
33regulation of gamma-delta T cell activation (GO:0046643)3.47265694
34regulation of B cell receptor signaling pathway (GO:0050855)3.45808402
35response to muramyl dipeptide (GO:0032495)3.44420691
36negative regulation of interleukin-12 production (GO:0032695)3.43900359
37regulation of platelet aggregation (GO:0090330)3.42799355
38production of molecular mediator involved in inflammatory response (GO:0002532)3.42035718
39leukocyte degranulation (GO:0043299)3.38272924
40regulation of myeloid leukocyte mediated immunity (GO:0002886)3.37177517
41positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.36306987
42macrophage activation involved in immune response (GO:0002281)3.35776044
43regulation of interferon-alpha production (GO:0032647)3.35745592
44negative regulation of phagocytosis (GO:0050765)3.34083698
45neutrophil mediated immunity (GO:0002446)3.27831696
46leukocyte migration involved in inflammatory response (GO:0002523)3.26956445
47defense response to protozoan (GO:0042832)3.26697844
48aminoglycoside antibiotic metabolic process (GO:0030647)3.26557183
49antigen processing and presentation of endogenous antigen (GO:0019883)3.22801701
50regulation of leukocyte degranulation (GO:0043300)3.21661711
51macrophage activation (GO:0042116)3.20930128
52thrombin receptor signaling pathway (GO:0070493)3.20265913
53B cell receptor signaling pathway (GO:0050853)3.19408984
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.18681331
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.18681331
56positive regulation of B cell differentiation (GO:0045579)3.16886705
57regulation of gamma-delta T cell differentiation (GO:0045586)3.15456201
58positive regulation of antigen processing and presentation (GO:0002579)3.12830878
59regulation of platelet activation (GO:0010543)3.12462863
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.11232329
61myeloid cell activation involved in immune response (GO:0002275)3.08490243
62pinocytosis (GO:0006907)3.06300434
63response to interferon-beta (GO:0035456)3.05266412
64negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.04972975
65positive regulation of leukocyte degranulation (GO:0043302)3.03982392
66hydrogen peroxide biosynthetic process (GO:0050665)3.03120212
67detection of biotic stimulus (GO:0009595)3.02958519
68cytidine deamination (GO:0009972)3.02733311
69cytidine metabolic process (GO:0046087)3.02733311
70cytidine catabolic process (GO:0006216)3.02733311
71type I interferon signaling pathway (GO:0060337)3.02701257
72cellular response to type I interferon (GO:0071357)3.02701257
73reactive oxygen species biosynthetic process (GO:1903409)3.02340752
74interferon-gamma production (GO:0032609)3.02257436
75interferon-gamma-mediated signaling pathway (GO:0060333)3.02253139
76response to type I interferon (GO:0034340)3.00334194
77response to interleukin-15 (GO:0070672)2.97815270
78regulation of T-helper 2 cell differentiation (GO:0045628)2.97568707
79negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.96498154
80negative regulation of T-helper cell differentiation (GO:0045623)2.96498154
81negative regulation of lymphocyte mediated immunity (GO:0002707)2.95281340
82positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.94754235
83response to protozoan (GO:0001562)2.94070990
84germinal center formation (GO:0002467)2.93772049
85leukocyte mediated cytotoxicity (GO:0001909)2.92923428
86positive regulation of defense response to virus by host (GO:0002230)2.92833495
87G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.92078449
88response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90795070
89response to host immune response (GO:0052572)2.90795070
90positive regulation of toll-like receptor signaling pathway (GO:0034123)2.89403102
91response to interferon-alpha (GO:0035455)2.89018563
92peptide catabolic process (GO:0043171)2.84085487
93negative regulation of T cell mediated immunity (GO:0002710)2.84056159
94regulation of antigen processing and presentation (GO:0002577)2.83326799
95regulation of B cell differentiation (GO:0045577)2.82470122
96mast cell activation (GO:0045576)2.82436997
97NIK/NF-kappaB signaling (GO:0038061)2.81181048
98negative regulation of interleukin-17 production (GO:0032700)2.80462301
99lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79909289
100positive regulation of gamma-delta T cell activation (GO:0046645)2.79421939
101cellular response to interleukin-15 (GO:0071350)2.78054415
102myeloid dendritic cell activation (GO:0001773)2.76888187
103cellular response to interferon-beta (GO:0035458)2.76471454
104positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.75553517
105regulation of germinal center formation (GO:0002634)2.74862106
106positive regulation of interferon-beta production (GO:0032728)2.74550591
107leukocyte aggregation (GO:0070486)2.73641947
108regulation of T cell mediated cytotoxicity (GO:0001914)2.72112056
109positive regulation of cellular amide metabolic process (GO:0034250)2.71559962
110negative regulation of leukocyte mediated immunity (GO:0002704)2.71069147
111regulation of hypersensitivity (GO:0002883)2.70486980
112lymphocyte mediated immunity (GO:0002449)2.69313954
113superoxide anion generation (GO:0042554)2.68612347
114positive regulation of type 2 immune response (GO:0002830)2.68517440
115regulation of interleukin-17 production (GO:0032660)2.67625845
116positive regulation of macrophage differentiation (GO:0045651)2.65682798
117positive regulation of T cell mediated cytotoxicity (GO:0001916)2.65627797
118Arp2/3 complex-mediated actin nucleation (GO:0034314)2.65342198
119regulation of regulatory T cell differentiation (GO:0045589)2.65142395
120regulation of mast cell activation (GO:0033003)2.64110482
121regulation of regulated secretory pathway (GO:1903305)2.64073398
122response to host (GO:0075136)2.63497013
123response to host defenses (GO:0052200)2.63497013
124response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.63497013
125regulation of necroptotic process (GO:0060544)2.62593798
126regulation of memory T cell differentiation (GO:0043380)2.62088219
127phagocytosis, engulfment (GO:0006911)2.62054307
128regulation of mast cell degranulation (GO:0043304)2.61633191
129microglial cell activation (GO:0001774)2.61170789
130dendritic cell differentiation (GO:0097028)2.60696762
131protein localization to kinetochore (GO:0034501)2.58263850
132positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.56633618
133positive regulation of chemokine biosynthetic process (GO:0045080)2.56432409
134myeloid leukocyte mediated immunity (GO:0002444)2.56290883
135leukocyte mediated immunity (GO:0002443)2.55713694
136positive regulation of protein import into nucleus, translocation (GO:0033160)2.54285598
137T-helper 1 type immune response (GO:0042088)2.54154109
138cellular extravasation (GO:0045123)2.53791105
139regulation of mammary gland epithelial cell proliferation (GO:0033599)2.53790850
140detection of other organism (GO:0098543)2.53712313
141negative regulation of cell cycle G2/M phase transition (GO:1902750)2.53480494
142myeloid dendritic cell differentiation (GO:0043011)2.51280079
143regulation of chemokine biosynthetic process (GO:0045073)2.50953945
144negative regulation of viral genome replication (GO:0045071)2.50930585
145regulation of RIG-I signaling pathway (GO:0039535)2.48862551
146negative regulation of growth of symbiont in host (GO:0044130)2.48006843
147negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.48006843
148modulation of growth of symbiont involved in interaction with host (GO:0044144)2.48006843
149regulation of growth of symbiont in host (GO:0044126)2.48006843
150myeloid leukocyte activation (GO:0002274)2.46239016
151antigen processing and presentation via MHC class Ib (GO:0002475)2.46136130
152adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.45415157
153cytokine secretion (GO:0050663)2.44928279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.58058590
2E2F7_22180533_ChIP-Seq_HELA_Human5.00462578
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.90747672
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.71797790
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.42298499
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.19419031
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.16832122
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.05547497
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.95575176
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.88160445
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77847346
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.60966796
13* SCL_19346495_ChIP-Seq_HPC-7_Human2.60246211
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.49711956
15SPI1_23547873_ChIP-Seq_NB4_Human2.37021121
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35839707
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.24431119
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.24431119
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.24431119
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.20261774
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19683437
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.09417541
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02994652
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01556178
25BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99241458
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97051504
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95774071
28SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.94346487
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92461927
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86910080
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86770433
32* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85103100
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.84579270
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81786425
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.78616059
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75329473
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72452118
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.72273472
39MYB_26560356_Chip-Seq_TH2_Human1.67615542
40VDR_21846776_ChIP-Seq_THP-1_Human1.64631956
41GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64032764
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.60387031
43SPI1_23127762_ChIP-Seq_K562_Human1.57167573
44GATA1_19941826_ChIP-Seq_K562_Human1.52805529
45MYB_26560356_Chip-Seq_TH1_Human1.50574845
46VDR_24763502_ChIP-Seq_THP-1_Human1.48915947
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43607915
48MAF_26560356_Chip-Seq_TH1_Human1.42822365
49GATA2_19941826_ChIP-Seq_K562_Human1.42447836
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42064495
51GATA1_22025678_ChIP-Seq_K562_Human1.40929546
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40668074
53NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40418406
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39985585
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39490729
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35651470
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35405051
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34441129
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.31998302
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31557946
61PU_27001747_Chip-Seq_BMDM_Mouse1.29585520
62* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.26689159
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24808999
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24749264
65MYC_22102868_ChIP-Seq_BL_Human1.24502555
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24421459
67TCF7_22412390_ChIP-Seq_EML_Mouse1.23687111
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20801268
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.20273411
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18840968
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17822866
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17535034
73* TFEB_21752829_ChIP-Seq_HELA_Human1.14765747
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14297850
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14173188
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12385040
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06645369
78UTX_26944678_Chip-Seq_JUKART_Human1.05932305
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04949133
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04501222
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04278812
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04155287
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.03727066
84RUNX_20019798_ChIP-Seq_JUKART_Human1.02816699
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02592958
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02460183
87* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99633897
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99586463
89STAT1_20625510_ChIP-Seq_HELA_Human0.97345696
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96917682
91EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92653435
92* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91626300
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91027712
94GATA3_26560356_Chip-Seq_TH2_Human0.90872361
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88240012
96GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88224205
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87371527
98GATA3_27048872_Chip-Seq_THYMUS_Human0.86920634
99RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86733731
100* SMRT_27268052_Chip-Seq_Bcells_Human0.85610149
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85419840
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84800788
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84056742
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83737524
105SPI1_20517297_ChIP-Seq_HL60_Human0.82545271
106ELK1_19687146_ChIP-ChIP_HELA_Human0.82542909
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82485812
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.80889438
109PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80403939
110SALL4_22934838_ChIP-ChIP_CD34+_Human0.79703567
111NCOR1_26117541_ChIP-Seq_K562_Human0.79549143
112VDR_24787735_ChIP-Seq_THP-1_Human0.78877327
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78651348
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.78338517
115FOXO3_23340844_ChIP-Seq_DLD1_Human0.77971607
116* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77520713
117* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77520713
118IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76850332
119* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.76641347
120SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76469723
121E2F1_21310950_ChIP-Seq_MCF-7_Human0.76153337
122SOX2_20726797_ChIP-Seq_SW620_Human0.75859946
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75586782
124ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75560160
125CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75162300
126VDR_23849224_ChIP-Seq_CD4+_Human0.73850116
127MAF_26560356_Chip-Seq_TH2_Human0.73114605
128TCF3_18692474_ChIP-Seq_MEFs_Mouse0.70955489
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.70048852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.01696980
2MP0003436_decreased_susceptibility_to3.20580164
3MP0009785_altered_susceptibility_to3.00239518
4MP0006082_CNS_inflammation2.79638522
5MP0002148_abnormal_hypersensitivity_rea2.79264283
6MP0002419_abnormal_innate_immunity2.65478643
7MP0005025_abnormal_response_to2.58339086
8MP0002396_abnormal_hematopoietic_system2.54859150
9* MP0005000_abnormal_immune_tolerance2.50883214
10* MP0002452_abnormal_antigen_presenting2.35784148
11MP0005671_abnormal_response_to2.35653849
12MP0000685_abnormal_immune_system2.34119499
13* MP0001800_abnormal_humoral_immune2.33327394
14MP0001790_abnormal_immune_system2.29209603
15MP0005387_immune_system_phenotype2.29209603
16* MP0002723_abnormal_immune_serum2.17869925
17MP0005058_abnormal_lysosome_morphology2.15591131
18MP0010352_gastrointestinal_tract_polyps2.13356481
19* MP0001819_abnormal_immune_cell2.08146129
20MP0005464_abnormal_platelet_physiology2.07451854
21* MP0002420_abnormal_adaptive_immunity2.07095901
22MP0003724_increased_susceptibility_to2.06002297
23MP0003172_abnormal_lysosome_physiology1.99801490
24MP0008004_abnormal_stomach_pH1.99421043
25MP0000569_abnormal_digit_pigmentation1.91068178
26MP0005075_abnormal_melanosome_morpholog1.84312770
27MP0003183_abnormal_peptide_metabolism1.83719050
28MP0002405_respiratory_system_inflammati1.82036224
29MP0003303_peritoneal_inflammation1.78009549
30MP0005397_hematopoietic_system_phenotyp1.75389551
31MP0001545_abnormal_hematopoietic_system1.75389551
32MP0001853_heart_inflammation1.74379320
33MP0002254_reproductive_system_inflammat1.72351376
34MP0008057_abnormal_DNA_replication1.71106468
35MP0000490_abnormal_crypts_of1.69224184
36* MP0002398_abnormal_bone_marrow1.67720865
37MP0010155_abnormal_intestine_physiology1.66914506
38MP0002277_abnormal_respiratory_mucosa1.66297909
39MP0005174_abnormal_tail_pigmentation1.64637409
40* MP0000716_abnormal_immune_system1.64429508
41MP0009278_abnormal_bone_marrow1.63437476
42MP0000689_abnormal_spleen_morphology1.59016517
43MP0000343_altered_response_to1.56035561
44MP0001845_abnormal_inflammatory_respons1.55757569
45MP0008260_abnormal_autophagy1.54761395
46MP0003191_abnormal_cellular_cholesterol1.54318348
47MP0002006_tumorigenesis1.53271699
48MP0003448_altered_tumor_morphology1.52101047
49MP0002166_altered_tumor_susceptibility1.50803842
50MP0004264_abnormal_extraembryonic_tissu1.48884772
51MP0000858_altered_metastatic_potential1.47343015
52* MP0002429_abnormal_blood_cell1.45983757
53MP0003806_abnormal_nucleotide_metabolis1.45940777
54MP0002722_abnormal_immune_system1.45101017
55MP0001533_abnormal_skeleton_physiology1.42641100
56MP0004947_skin_inflammation1.41374361
57MP0004808_abnormal_hematopoietic_stem1.40932968
58MP0008469_abnormal_protein_level1.36349843
59MP0005310_abnormal_salivary_gland1.32767141
60MP0003866_abnormal_defecation1.29982404
61MP0009764_decreased_sensitivity_to1.27814039
62MP0001851_eye_inflammation1.26726123
63MP0009333_abnormal_splenocyte_physiolog1.25251077
64MP0003011_delayed_dark_adaptation1.21564213
65MP0000465_gastrointestinal_hemorrhage1.20773178
66MP0010307_abnormal_tumor_latency1.16573418
67MP0003300_gastrointestinal_ulcer1.14624853
68MP0003828_pulmonary_edema1.14420621
69MP0004510_myositis1.13672839
70MP0003186_abnormal_redox_activity1.13048614
71MP0004782_abnormal_surfactant_physiolog1.12575097
72MP0005451_abnormal_body_composition1.11379262
73MP0003075_altered_response_to1.08811860
74MP0003693_abnormal_embryo_hatching1.07959904
75MP0003566_abnormal_cell_adhesion1.01963878
76MP0005167_abnormal_blood-brain_barrier1.01351693
77MP0003077_abnormal_cell_cycle1.01168046
78MP0008007_abnormal_cellular_replicative1.00853266
79MP0005257_abnormal_intraocular_pressure1.00014376
80MP0000371_diluted_coat_color0.98703387
81MP0004957_abnormal_blastocyst_morpholog0.95855803
82MP0010094_abnormal_chromosome_stability0.95558818
83MP0006292_abnormal_olfactory_placode0.94209907
84MP0003763_abnormal_thymus_physiology0.92984350
85MP0002019_abnormal_tumor_incidence0.92566649
86MP0002132_abnormal_respiratory_system0.91555586
87MP0001873_stomach_inflammation0.90672683
88MP0002998_abnormal_bone_remodeling0.89520843
89MP0009763_increased_sensitivity_to0.89389950
90MP0002332_abnormal_exercise_endurance0.87812981
91MP0000015_abnormal_ear_pigmentation0.87625271
92MP0005023_abnormal_wound_healing0.87138514
93MP0005390_skeleton_phenotype0.85709247
94MP0006054_spinal_hemorrhage0.81911104
95MP0000703_abnormal_thymus_morphology0.81617196
96MP0001663_abnormal_digestive_system0.80297564
97MP0000313_abnormal_cell_death0.79414997
98MP0003656_abnormal_erythrocyte_physiolo0.77705865
99MP0002139_abnormal_hepatobiliary_system0.77234032
100MP0003453_abnormal_keratinocyte_physiol0.77208598
101MP0003045_fibrosis0.76944415
102MP0005165_increased_susceptibility_to0.76929663
103MP0002877_abnormal_melanocyte_morpholog0.75799413
104MP0005164_abnormal_response_to0.74269185
105MP0002933_joint_inflammation0.74096328
106MP0009840_abnormal_foam_cell0.73166300
107MP0003795_abnormal_bone_structure0.72800366
108MP0003638_abnormal_response/metabolism_0.72223005
109MP0004381_abnormal_hair_follicle0.70142766
110MP0000249_abnormal_blood_vessel0.69653051
111MP0000604_amyloidosis0.69426177
112MP0004883_abnormal_blood_vessel0.68994935
113MP0002095_abnormal_skin_pigmentation0.68815287
114MP0008874_decreased_physiological_sensi0.68630808
115MP0005166_decreased_susceptibility_to0.68187060
116MP0003111_abnormal_nucleus_morphology0.67860302
117MP0009765_abnormal_xenobiotic_induced0.66870708
118MP0002138_abnormal_hepatobiliary_system0.65417413
119MP0003252_abnormal_bile_duct0.64351353
120MP0003690_abnormal_glial_cell0.60711024
121MP0000230_abnormal_systemic_arterial0.59155135
122MP0000609_abnormal_liver_physiology0.56908660
123MP0005084_abnormal_gallbladder_morpholo0.55826086
124MP0004484_altered_response_of0.55601030

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.36549474
2Recurrent bacterial skin infections (HP:0005406)5.85143902
3Eczematoid dermatitis (HP:0000976)5.40580249
4Myositis (HP:0100614)4.57297533
5Elevated erythrocyte sedimentation rate (HP:0003565)4.42391789
6Recurrent gram-negative bacterial infections (HP:0005420)4.35688427
7Purpura (HP:0000979)4.09756810
8Abnormal platelet volume (HP:0011876)3.97700985
9Abnormality of macrophages (HP:0004311)3.90365855
10Orchitis (HP:0100796)3.81687819
11Increased mean platelet volume (HP:0011877)3.75967000
12Menorrhagia (HP:0000132)3.74218033
13Gingivitis (HP:0000230)3.63981988
14Abnormality of glycolipid metabolism (HP:0010969)3.57309245
15Abnormality of liposaccharide metabolism (HP:0010968)3.57309245
16Abnormality of glycosphingolipid metabolism (HP:0004343)3.57309245
17Vacuolated lymphocytes (HP:0001922)3.49158839
18Recurrent skin infections (HP:0001581)3.48900567
19Mediastinal lymphadenopathy (HP:0100721)3.42840853
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.37405503
21Chromsome breakage (HP:0040012)3.35754516
22Recurrent fungal infections (HP:0002841)3.26290884
23Cellulitis (HP:0100658)3.17721177
24Obstructive lung disease (HP:0006536)3.08553866
25Chronic obstructive pulmonary disease (HP:0006510)3.08553866
26T lymphocytopenia (HP:0005403)3.04684450
27Autoimmune thrombocytopenia (HP:0001973)2.99054676
28Abnormality of T cell number (HP:0011839)2.97334355
29Recurrent viral infections (HP:0004429)2.97090496
30Periodontitis (HP:0000704)2.96894306
31Petechiae (HP:0000967)2.91344039
32Systemic lupus erythematosus (HP:0002725)2.90421846
33Reduced antithrombin III activity (HP:0001976)2.88074570
34Increased cerebral lipofuscin (HP:0011813)2.87139235
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.83857620
36Vasculitis (HP:0002633)2.81025231
37Optic neuritis (HP:0100653)2.80672728
38Retrobulbar optic neuritis (HP:0100654)2.80672728
39Gastrointestinal infarctions (HP:0005244)2.79531167
40Agnosia (HP:0010524)2.77011481
41Pustule (HP:0200039)2.72432589
42Keratoconjunctivitis (HP:0001096)2.68294059
43Prostate neoplasm (HP:0100787)2.63394500
44Abnormality of the prostate (HP:0008775)2.62808987
45Abnormality of the vasculature of the conjunctiva (HP:0008054)2.56682848
46Interstitial pulmonary disease (HP:0006530)2.53367282
47Meningitis (HP:0001287)2.51254377
48Thrombocytosis (HP:0001894)2.51078217
49Gastrointestinal inflammation (HP:0004386)2.48294996
50Abnormality of T cells (HP:0002843)2.48098400
51Gingival bleeding (HP:0000225)2.47724475
52Urticaria (HP:0001025)2.47043242
53Hypochromic microcytic anemia (HP:0004840)2.46470640
54IgM deficiency (HP:0002850)2.45323127
55Stomatitis (HP:0010280)2.44853748
56Pulmonary infiltrates (HP:0002113)2.44438409
57Spontaneous hematomas (HP:0007420)2.44365861
58Osteomyelitis (HP:0002754)2.43870641
59Leukocytosis (HP:0001974)2.42527252
60Cheilitis (HP:0100825)2.38899711
61Panhypogammaglobulinemia (HP:0003139)2.37963984
62Abnormality of T cell physiology (HP:0011840)2.32871400
63Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.31362076
64Upper motor neuron abnormality (HP:0002127)2.30639516
65Axonal loss (HP:0003447)2.29301955
66Recurrent cutaneous fungal infections (HP:0011370)2.26506587
67Chronic mucocutaneous candidiasis (HP:0002728)2.26506587
68Joint swelling (HP:0001386)2.25844236
69Epistaxis (HP:0000421)2.25674399
70Basal ganglia calcification (HP:0002135)2.24895970
71Nasal polyposis (HP:0100582)2.24380161
72Disinhibition (HP:0000734)2.23880224
73Loss of speech (HP:0002371)2.22831127
74Autoimmune hemolytic anemia (HP:0001890)2.21392407
75Chest pain (HP:0100749)2.21178058
76Episodic fever (HP:0001954)2.21053782
77Hypochromic anemia (HP:0001931)2.20403895
78Pulmonary embolism (HP:0002204)2.20354561
79Conjunctival telangiectasia (HP:0000524)2.19788494
80Chronic otitis media (HP:0000389)2.18516265
81Recurrent pneumonia (HP:0006532)2.16528484
82Abnormal delayed hypersensitivity skin test (HP:0002963)2.15232717
83Abnormality of the pleura (HP:0002103)2.13876200
84Anorexia (HP:0002039)2.13503960
85Abnormality of iron homeostasis (HP:0011031)2.13213031
86Gangrene (HP:0100758)2.12849140
87Aplastic anemia (HP:0001915)2.12786138
88Abnormality of the nasal mucosa (HP:0000433)2.12616278
89Vertigo (HP:0002321)2.11772737
90Myelodysplasia (HP:0002863)2.11633071
91Hemoptysis (HP:0002105)2.10836681
92Bruising susceptibility (HP:0000978)2.10581663
93Poor head control (HP:0002421)2.09369930
94Fatigue (HP:0012378)2.09295507
95Eosinophilia (HP:0001880)2.07960763
96Premature loss of primary teeth (HP:0006323)2.07391936
97Agammaglobulinemia (HP:0004432)2.07082833
98Glomerulopathy (HP:0100820)2.06003359
99Myocardial infarction (HP:0001658)2.02590004
100Prolonged bleeding time (HP:0003010)2.02001597
101Increased serum ferritin (HP:0003281)2.01980273
102Bilateral microphthalmos (HP:0007633)1.99821797
103Polyneuropathy (HP:0001271)1.98136990
104Recurrent lower respiratory tract infections (HP:0002783)1.97432509
105Granulocytopenia (HP:0001913)1.95732886
106Increased IgM level (HP:0003496)1.95505177
107Chronic diarrhea (HP:0002028)1.95032574
108Dyschromatopsia (HP:0007641)1.93635005
109Arterial thrombosis (HP:0004420)1.93342733
110Hematochezia (HP:0002573)1.92753017
111Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90937331
112Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90937331
113Abnormality of polysaccharide metabolism (HP:0011012)1.90937331
114Pathologic fracture (HP:0002756)1.90760386
115Inflammation of the large intestine (HP:0002037)1.90748924
116Clubbing of toes (HP:0100760)1.90585566
117Skin rash (HP:0000988)1.90484231
118Skin ulcer (HP:0200042)1.89938624
119Type I transferrin isoform profile (HP:0003642)1.89845493
120Mucosal telangiectasiae (HP:0100579)1.89027817
121Mucopolysacchariduria (HP:0008155)1.88535922
122Urinary glycosaminoglycan excretion (HP:0003541)1.88535922
123Dysostosis multiplex (HP:0000943)1.88024243
124Hypergammaglobulinemia (HP:0010702)1.87646755
125Colitis (HP:0002583)1.85861376
126Leukopenia (HP:0001882)1.85526275
127Encephalitis (HP:0002383)1.85448593
128Abnormal platelet function (HP:0011869)1.84351287
129Impaired platelet aggregation (HP:0003540)1.84351287
130Thick nail (HP:0001805)1.83719302
131Glomerulonephritis (HP:0000099)1.83073007
132Hepatosplenomegaly (HP:0001433)1.82527731
133Multiple enchondromatosis (HP:0005701)1.80661665
134Keratoconjunctivitis sicca (HP:0001097)1.80611100
135Abnormality of chromosome stability (HP:0003220)1.79911594
136Joint hemorrhage (HP:0005261)1.79780544
137Amyloidosis (HP:0011034)1.78141133
138Combined immunodeficiency (HP:0005387)1.78047413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.96626520
2KIT3.14423250
3TGFBR23.09606000
4ERN13.04371317
5IRAK42.86761357
6MAP3K142.84505828
7BLK2.83289274
8RIPK42.38249480
9MAP4K12.37275846
10IRAK32.30763487
11STK102.18670076
12TBK12.10510271
13IKBKB2.10248332
14MATK2.09875604
15* CSF1R2.03376059
16TYK22.00968908
17ADRBK21.92886270
18GRK71.89917774
19GRK61.86395422
20JAK31.81417233
21GRK51.81101080
22PIM21.67144219
23IKBKE1.59643335
24BTK1.57594209
25TEC1.57269882
26FLT31.56569356
27NME21.43240073
28GRK11.43106720
29TAOK31.43042883
30TNK21.37228491
31PIK3CG1.37074081
32MOS1.34939807
33CSK1.32758104
34ZAP701.32715411
35MAP3K121.31880441
36EIF2AK21.31393567
37TXK1.27459573
38PTK2B1.24643611
39SYK1.23119319
40CHUK1.19695017
41MAP2K31.11314603
42PIM11.11160871
43PAK41.09753262
44FGFR31.07790631
45LYN1.07438921
46SIK31.05944247
47BMX1.01869581
48JAK11.00865470
49NEK91.00178951
50MYLK1.00122805
51MAP3K130.99624676
52STK40.98771119
53TESK20.98636769
54CDK70.96913811
55LCK0.96668903
56TTK0.96341007
57CLK10.95537263
58MAP3K10.93594527
59TRPM70.92550599
60MST1R0.90679693
61PDK10.90155205
62* HCK0.90072475
63MAP3K20.88870248
64PRKG20.86936791
65EPHB10.86595471
66MAPK70.86042698
67STK30.79012572
68RPS6KA40.78108072
69YES10.77327054
70ITK0.76681579
71JAK20.76437021
72PDPK10.73095563
73EIF2AK10.72384842
74MAP3K110.71698978
75ACVR1B0.68676438
76PRKCD0.67329985
77HIPK20.59700294
78IRAK20.59429898
79MAP3K50.59208555
80FES0.58912229
81ABL10.57522360
82PRPF4B0.56668535
83WEE10.56548681
84PRKCQ0.56327083
85TAOK20.54879061
86EPHA30.54593755
87KSR20.54231429
88CAMKK20.53486299
89MAPKAPK20.53286350
90MST40.53269638
91CDK60.52913125
92PBK0.52726995
93MAPK120.51906578
94ARAF0.51522841
95TAOK10.50411083
96ABL20.50389140
97BMPR20.49857165
98CDK40.49425817
99EGFR0.47764942
100NEK20.46656499
101* FYN0.46546265
102CAMK40.46466384
103CAMK1D0.46086854
104TGFBR10.45602053
105RPS6KB20.44974245
106STK240.44552822
107MAP3K30.44374381
108ATR0.43782663
109MAP2K60.43421117
110MARK30.42650780
111SCYL20.42368150
112PLK10.42201697
113LRRK20.40957989
114ILK0.37868128
115RAF10.37628940
116DYRK30.36282039
117IRAK10.35696125
118FER0.35413807
119FGR0.34645799
120BRSK20.34016916
121CDK190.33359785
122MAPK110.33025862
123* IGF1R0.32926974
124ADRBK10.32616005
125MAP3K60.32118078
126CHEK20.31640383
127PRKD10.31255712
128CDC42BPA0.31034517
129RPS6KA60.30995832
130MAPK40.30350323
131CDC70.29592891
132MAPKAPK30.29138445
133DAPK20.29025889
134AURKB0.28183027
135FGFR40.27605462
136MAP3K80.27175510
137ZAK0.25664690
138MAP3K100.23972312
139EIF2AK30.23815414

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.03774844
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.39366787
3RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.26759360
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23830160
5Staphylococcus aureus infection_Homo sapiens_hsa051502.23029194
6Other glycan degradation_Homo sapiens_hsa005112.22661506
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19610440
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.16268602
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.10865890
10Legionellosis_Homo sapiens_hsa051342.09929150
11Osteoclast differentiation_Homo sapiens_hsa043801.93885945
12Pertussis_Homo sapiens_hsa051331.91994291
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.91667396
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.90291874
15Herpes simplex infection_Homo sapiens_hsa051681.81274878
16Measles_Homo sapiens_hsa051621.80131699
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76067760
18Tuberculosis_Homo sapiens_hsa051521.74811039
19B cell receptor signaling pathway_Homo sapiens_hsa046621.74691641
20DNA replication_Homo sapiens_hsa030301.71282585
21Lysosome_Homo sapiens_hsa041421.67370400
22Malaria_Homo sapiens_hsa051441.66917624
23Influenza A_Homo sapiens_hsa051641.61787161
24Graft-versus-host disease_Homo sapiens_hsa053321.60857775
25Allograft rejection_Homo sapiens_hsa053301.58181413
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55273287
27Hematopoietic cell lineage_Homo sapiens_hsa046401.50980062
28Antigen processing and presentation_Homo sapiens_hsa046121.44969057
29Apoptosis_Homo sapiens_hsa042101.41964846
30Toxoplasmosis_Homo sapiens_hsa051451.39462204
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38010962
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.35723717
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30262985
34Primary immunodeficiency_Homo sapiens_hsa053401.29516608
35TNF signaling pathway_Homo sapiens_hsa046681.27298042
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24677529
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21338010
38Homologous recombination_Homo sapiens_hsa034401.20174296
39Salmonella infection_Homo sapiens_hsa051321.19409654
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18196840
41Phagosome_Homo sapiens_hsa041451.17208122
42Shigellosis_Homo sapiens_hsa051311.16891384
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15100396
44African trypanosomiasis_Homo sapiens_hsa051431.12858794
45Rheumatoid arthritis_Homo sapiens_hsa053231.11022452
46Asthma_Homo sapiens_hsa053101.08034027
47Base excision repair_Homo sapiens_hsa034101.07211221
48Arachidonic acid metabolism_Homo sapiens_hsa005901.07086175
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05161288
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.04637604
51Acute myeloid leukemia_Homo sapiens_hsa052211.03462465
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03378149
53Hepatitis B_Homo sapiens_hsa051611.02393295
54Mismatch repair_Homo sapiens_hsa034301.01584867
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97070780
56p53 signaling pathway_Homo sapiens_hsa041150.95369058
57Chemokine signaling pathway_Homo sapiens_hsa040620.93169344
58Non-homologous end-joining_Homo sapiens_hsa034500.92022293
59Caffeine metabolism_Homo sapiens_hsa002320.91100937
60Fanconi anemia pathway_Homo sapiens_hsa034600.90293316
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88870293
62Hepatitis C_Homo sapiens_hsa051600.87062981
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86209826
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84341335
65Fructose and mannose metabolism_Homo sapiens_hsa000510.82310446
66Pancreatic cancer_Homo sapiens_hsa052120.81125596
67Galactose metabolism_Homo sapiens_hsa000520.80613710
68Non-small cell lung cancer_Homo sapiens_hsa052230.75622303
69Platelet activation_Homo sapiens_hsa046110.75329011
70Collecting duct acid secretion_Homo sapiens_hsa049660.73411519
71One carbon pool by folate_Homo sapiens_hsa006700.72898778
72Endocytosis_Homo sapiens_hsa041440.72739423
73Vitamin B6 metabolism_Homo sapiens_hsa007500.69562230
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67725341
75Chronic myeloid leukemia_Homo sapiens_hsa052200.67638916
76Complement and coagulation cascades_Homo sapiens_hsa046100.67546358
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66164531
78Small cell lung cancer_Homo sapiens_hsa052220.65847075
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64527958
80Pentose phosphate pathway_Homo sapiens_hsa000300.63732588
81Ribosome_Homo sapiens_hsa030100.63571555
82Cell cycle_Homo sapiens_hsa041100.62250018
83Autoimmune thyroid disease_Homo sapiens_hsa053200.61113292
84Viral myocarditis_Homo sapiens_hsa054160.60977675
85Viral carcinogenesis_Homo sapiens_hsa052030.59816537
86Type I diabetes mellitus_Homo sapiens_hsa049400.57918015
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54441629
88Epstein-Barr virus infection_Homo sapiens_hsa051690.54096832
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53745497
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51036788
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49113842
92Sulfur metabolism_Homo sapiens_hsa009200.48804514
93T cell receptor signaling pathway_Homo sapiens_hsa046600.48451424
94Folate biosynthesis_Homo sapiens_hsa007900.48426386
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.47741541
96Systemic lupus erythematosus_Homo sapiens_hsa053220.46840757
97Nucleotide excision repair_Homo sapiens_hsa034200.46404248
98Renal cell carcinoma_Homo sapiens_hsa052110.45914321
99VEGF signaling pathway_Homo sapiens_hsa043700.43199517
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42601530
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41969690
102Amoebiasis_Homo sapiens_hsa051460.41894884
103HTLV-I infection_Homo sapiens_hsa051660.40099138
104Thyroid cancer_Homo sapiens_hsa052160.38750750
105Dorso-ventral axis formation_Homo sapiens_hsa043200.38184452
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38134163
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.37847644
108Sphingolipid metabolism_Homo sapiens_hsa006000.37434261
109MicroRNAs in cancer_Homo sapiens_hsa052060.37394719
110RNA degradation_Homo sapiens_hsa030180.37258071
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36813134
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.35990730
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.35334926
114Renin-angiotensin system_Homo sapiens_hsa046140.34781085
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.34336237
116Notch signaling pathway_Homo sapiens_hsa043300.33027894
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32824776
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32401911
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32383022
120Prolactin signaling pathway_Homo sapiens_hsa049170.28069662
121Regulation of autophagy_Homo sapiens_hsa041400.26807087
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24077586
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.22174018
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.21748149
125HIF-1 signaling pathway_Homo sapiens_hsa040660.21392246

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