SKI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)3.53385972
2cytoskeletal anchoring at plasma membrane (GO:0007016)3.38780885
3protein heterotrimerization (GO:0070208)3.28155011
4stress fiber assembly (GO:0043149)3.18847720
5response to laminar fluid shear stress (GO:0034616)3.01596127
6layer formation in cerebral cortex (GO:0021819)2.92549936
7regulation of NFAT protein import into nucleus (GO:0051532)2.91743686
8plasma membrane repair (GO:0001778)2.90012214
9locomotory exploration behavior (GO:0035641)2.84636929
10cerebellar granule cell differentiation (GO:0021707)2.84496711
11positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.82272244
12synaptic vesicle maturation (GO:0016188)2.76435540
13regulation of extracellular matrix disassembly (GO:0010715)2.76321422
14apoptotic cell clearance (GO:0043277)2.73914398
15negative regulation of fatty acid transport (GO:2000192)2.73777287
16sodium ion export (GO:0071436)2.70878309
17protein localization to endosome (GO:0036010)2.69720781
18positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.68680966
19positive regulation of blood vessel endothelial cell migration (GO:0043536)2.67186957
20establishment of nucleus localization (GO:0040023)2.65471370
21positive regulation of receptor recycling (GO:0001921)2.65038829
22negative regulation of catenin import into nucleus (GO:0035414)2.64984134
23cell migration involved in heart development (GO:0060973)2.63906752
24adherens junction assembly (GO:0034333)2.63849881
25hippo signaling (GO:0035329)2.62195462
26regulation of ARF GTPase activity (GO:0032312)2.61132603
27mannose metabolic process (GO:0006013)2.61016232
28positive regulation of fibroblast migration (GO:0010763)2.60839684
29insulin-like growth factor receptor signaling pathway (GO:0048009)2.59947675
30vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.57117583
31atrioventricular valve morphogenesis (GO:0003181)2.56786981
32barbed-end actin filament capping (GO:0051016)2.56673536
33axon extension involved in axon guidance (GO:0048846)2.53561226
34neuron projection extension involved in neuron projection guidance (GO:1902284)2.53561226
35apoptotic process involved in morphogenesis (GO:0060561)2.48909940
36extracellular matrix assembly (GO:0085029)2.46987010
37regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46325139
38planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45729145
39cell-substrate junction assembly (GO:0007044)2.43362652
40cytoplasmic mRNA processing body assembly (GO:0033962)2.43326142
41peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.42477423
42regulation of p38MAPK cascade (GO:1900744)2.41545369
43regulation of ARF protein signal transduction (GO:0032012)2.40629025
44cell migration involved in sprouting angiogenesis (GO:0002042)2.40100109
45collagen fibril organization (GO:0030199)2.38192238
46bone trabecula formation (GO:0060346)2.37993210
47cortical cytoskeleton organization (GO:0030865)2.37578110
48embryonic process involved in female pregnancy (GO:0060136)2.36958642
49negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.36559967
50endodermal cell differentiation (GO:0035987)2.35918828
51regulation of synapse structural plasticity (GO:0051823)2.34891683
52focal adhesion assembly (GO:0048041)2.31955507
53cell-substrate adherens junction assembly (GO:0007045)2.31955507
54polarized epithelial cell differentiation (GO:0030859)2.31938724
55negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.30095411
56substrate adhesion-dependent cell spreading (GO:0034446)2.28478573
57synaptic vesicle docking involved in exocytosis (GO:0016081)2.28356760
58nerve growth factor signaling pathway (GO:0038180)2.24740093
59cellular potassium ion homeostasis (GO:0030007)2.23537609
60regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.23396299
61dendrite morphogenesis (GO:0048813)2.22993479
62cardiac myofibril assembly (GO:0055003)2.22534708
63vascular endothelial growth factor signaling pathway (GO:0038084)2.21852339
64epithelial cell-cell adhesion (GO:0090136)2.21666617
65activation of Rac GTPase activity (GO:0032863)2.20572288
66venous blood vessel morphogenesis (GO:0048845)2.20470734
67cellular response to monoamine stimulus (GO:0071868)2.19627832
68cellular response to catecholamine stimulus (GO:0071870)2.19627832
69protein targeting to plasma membrane (GO:0072661)2.19245251
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.18923639
71positive regulation of extracellular matrix organization (GO:1903055)2.18275026
72negative regulation of Ras protein signal transduction (GO:0046580)2.18192317
73glutamate secretion (GO:0014047)2.18027066
74maternal placenta development (GO:0001893)2.17736755
75semaphorin-plexin signaling pathway (GO:0071526)2.17537854
76basement membrane organization (GO:0071711)2.16728340
77negative regulation of cell killing (GO:0031342)2.16676062
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.16676062
79cortical actin cytoskeleton organization (GO:0030866)2.16540254
80signal complex assembly (GO:0007172)2.16348907
81activation of JUN kinase activity (GO:0007257)2.15960354
82cell communication by electrical coupling (GO:0010644)2.15903002
83positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.15787605
84positive regulation of histone deacetylation (GO:0031065)2.15497517
85regulation of glucose import in response to insulin stimulus (GO:2001273)2.15134826
86negative regulation of heart growth (GO:0061117)2.15108351
87negative regulation of cardiac muscle tissue growth (GO:0055022)2.15108351
88vocalization behavior (GO:0071625)2.15074414
89lymph vessel development (GO:0001945)2.14867940
90positive regulation of glycogen biosynthetic process (GO:0045725)2.14785111
91regulation of hippo signaling (GO:0035330)2.14382295
92endothelial cell chemotaxis (GO:0035767)2.14194962
93NLS-bearing protein import into nucleus (GO:0006607)2.13967271
94establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.12664317
95positive regulation of protein dephosphorylation (GO:0035307)2.12621479
96neural tube development (GO:0021915)2.12239270
97negative regulation of myotube differentiation (GO:0010832)2.12048662
98regulation of clathrin-mediated endocytosis (GO:2000369)2.11137062
99hemidesmosome assembly (GO:0031581)2.10030824
100negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.09980705
101negative regulation of small GTPase mediated signal transduction (GO:0051058)2.09925471
1023-UTR-mediated mRNA stabilization (GO:0070935)2.09643621
103cell volume homeostasis (GO:0006884)2.08575023
104negative regulation of chondrocyte differentiation (GO:0032331)2.08526784
105neuromuscular process controlling balance (GO:0050885)2.08136271
106cell-cell junction maintenance (GO:0045217)2.07978256
107endocytic recycling (GO:0032456)2.07592435
108regulation of early endosome to late endosome transport (GO:2000641)2.06548943
109dendritic spine morphogenesis (GO:0060997)2.06358024
110regulation of tight junction assembly (GO:2000810)2.06264816
111cell adhesion mediated by integrin (GO:0033627)2.06160219
112activation of protein kinase A activity (GO:0034199)2.05427462
113regulation of extracellular matrix organization (GO:1903053)2.05273893
114positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.04954054
115substrate-dependent cell migration (GO:0006929)2.04714983
116hypotonic response (GO:0006971)2.04571343
117glucocorticoid receptor signaling pathway (GO:0042921)2.04501455
118cellular protein complex localization (GO:0034629)2.04435731
119amino acid import (GO:0043090)2.04234217
120cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.03805947
121negative regulation of homotypic cell-cell adhesion (GO:0034111)2.03790400
122positive regulation of myotube differentiation (GO:0010831)2.03789984
123response to fluid shear stress (GO:0034405)2.03547942
124platelet-derived growth factor receptor signaling pathway (GO:0048008)2.03482074
125regulation of SMAD protein import into nucleus (GO:0060390)2.01974395
126regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.01822614
127regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.01818576
128cell migration in hindbrain (GO:0021535)2.01791636
129axon extension (GO:0048675)2.01659148
130protein retention in ER lumen (GO:0006621)2.01113110
131dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.00965151
132pre-miRNA processing (GO:0031054)2.00811831
133epithelial cell differentiation involved in prostate gland development (GO:0060742)2.00769711
134actin filament bundle assembly (GO:0051017)2.00500152
135actin filament bundle organization (GO:0061572)2.00500152
136regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.00357092
137positive regulation of axon extension (GO:0045773)2.00056265
138regulation of lipid kinase activity (GO:0043550)1.99800512
139ovulation cycle (GO:0042698)1.99667088
140positive regulation of epithelial to mesenchymal transition (GO:0010718)1.99233732
141negative regulation of cell size (GO:0045792)1.98314063
142skin morphogenesis (GO:0043589)1.97894723
143positive regulation of SMAD protein import into nucleus (GO:0060391)1.95914314
144G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)1.95196713
145blood vessel endothelial cell migration (GO:0043534)1.94383104
146growth hormone receptor signaling pathway (GO:0060396)1.94010691
147clathrin coat assembly (GO:0048268)1.93938240
148heart morphogenesis (GO:0003007)1.93517595
149positive regulation of synapse maturation (GO:0090129)1.93385944
150adherens junction organization (GO:0034332)1.92662561
151regulation of establishment of planar polarity (GO:0090175)1.92578954
152negative regulation of cartilage development (GO:0061037)1.90813811
153regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.90662635
154positive regulation of Rap GTPase activity (GO:0032854)1.90224634
155cell junction maintenance (GO:0034331)1.89787946
156Wnt signaling pathway, planar cell polarity pathway (GO:0060071)1.89783767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06862857
2* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.32234438
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.32110523
4WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.31987772
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.12360761
6* KDM2B_26808549_Chip-Seq_K562_Human2.05541459
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.01958817
8* KDM2B_26808549_Chip-Seq_DND41_Human2.01150844
9ZFP281_18757296_ChIP-ChIP_E14_Mouse1.99684294
10* VDR_21846776_ChIP-Seq_THP-1_Human1.98862387
11DROSHA_22980978_ChIP-Seq_HELA_Human1.97327411
12* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.91194816
13ZFP281_27345836_Chip-Seq_ESCs_Mouse1.89181040
14* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.88709052
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87534179
16RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86173608
17EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86173608
18EGR1_19374776_ChIP-ChIP_THP-1_Human1.83132662
19* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.81054557
20* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.79121452
21* KDM2B_26808549_Chip-Seq_JURKAT_Human1.76813586
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73939345
23* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.73095786
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72673144
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71082522
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.66767341
27* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64818994
28* ELK3_25401928_ChIP-Seq_HUVEC_Human1.58904306
29EZH2_22144423_ChIP-Seq_EOC_Human1.58381291
30* TCF7_22412390_ChIP-Seq_EML_Mouse1.54552699
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54417079
32* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53223075
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.53000246
34* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51631981
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.49967978
36* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49964086
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.49608968
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49241846
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49076464
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48913309
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.46356985
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45795055
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.45711546
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44893941
45LXR_22292898_ChIP-Seq_THP-1_Human1.42829389
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42243903
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41881969
48JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41305591
49AR_21572438_ChIP-Seq_LNCaP_Human1.39993682
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39743877
51CLOCK_20551151_ChIP-Seq_293T_Human1.39639354
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.39207012
53* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38775924
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.35781357
55* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34325109
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.34298957
57SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32739413
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.32625608
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32422098
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31373434
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30177903
62ZNF263_19887448_ChIP-Seq_K562_Human1.29105791
63* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28144476
64* RACK7_27058665_Chip-Seq_MCF-7_Human1.27110841
65* VDR_24763502_ChIP-Seq_THP-1_Human1.26809654
66* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.25613620
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.24144410
68* EZH2_27294783_Chip-Seq_ESCs_Mouse1.24031112
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23713096
70MYC_22102868_ChIP-Seq_BL_Human1.23584290
71* SA1_27219007_Chip-Seq_ERYTHROID_Human1.23325429
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.22800740
73TP53_16413492_ChIP-PET_HCT116_Human1.22615979
74SMC4_20622854_ChIP-Seq_HELA_Human1.21436235
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20193881
76* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19708769
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.18859880
78* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17252777
79DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16587915
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.16219749
81* RING1B_27294783_Chip-Seq_NPCs_Mouse1.15917317
82* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15789961
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15742830
84AHR_22903824_ChIP-Seq_MCF-7_Human1.15413976
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.15049218
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14089318
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.13964822
88* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13652464
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13490523
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.13324650
91TBX20_22328084_ChIP-Seq_HEART_Mouse1.13259235
92TBX20_22080862_ChIP-Seq_HEART_Mouse1.13259235
93* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.12995076
94CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12366220
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11063738
96TP53_20018659_ChIP-ChIP_R1E_Mouse1.10934705
97ESR1_21235772_ChIP-Seq_MCF-7_Human1.10871993
98* CREB1_26743006_Chip-Seq_LNCaP_Human1.07405527
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.06689101
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06624699
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06463578
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.06049125
103* CTCF_27219007_Chip-Seq_Bcells_Human1.04699729
104* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03178036
105* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03126075
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.03092376
107* UBF1/2_26484160_Chip-Seq_HMECs_Human1.02817401
108* P68_20966046_ChIP-Seq_HELA_Human1.02169201
109* MAF_26560356_Chip-Seq_TH1_Human1.01731737
110* TP53_22127205_ChIP-Seq_IMR90_Human1.00828551
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00447453
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99197698
113TET1_21451524_ChIP-Seq_MESCs_Mouse0.99166062
114CJUN_26792858_Chip-Seq_BT549_Human0.97207311
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96611180
116TP53_23651856_ChIP-Seq_MEFs_Mouse0.96267311
117ARNT_22903824_ChIP-Seq_MCF-7_Human0.95138002
118RXR_22108803_ChIP-Seq_LS180_Human0.95081521
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94818387
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94812684
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.93968725
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93817561
123GATA1_19941826_ChIP-Seq_K562_Human0.93415223
124BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93253437
125* RUNX1_22412390_ChIP-Seq_EML_Mouse0.92747393
126* UTX_26944678_Chip-Seq_JUKART_Human0.92169404
127* AR_19668381_ChIP-Seq_PC3_Human0.91864521
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91139069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.39284929
2MP0003705_abnormal_hypodermis_morpholog4.13336538
3MP0005275_abnormal_skin_tensile3.11911955
4MP0004859_abnormal_synaptic_plasticity3.10138365
5MP0005409_darkened_coat_color2.59323875
6MP0005503_abnormal_tendon_morphology2.52809137
7MP0005623_abnormal_meninges_morphology2.48898433
8MP0003279_aneurysm2.40870062
9MP0005076_abnormal_cell_differentiation2.34598504
10MP0003300_gastrointestinal_ulcer2.16007221
11MP0004272_abnormal_basement_membrane2.07657852
12MP0003303_peritoneal_inflammation2.03559776
13MP0001958_emphysema2.00793784
14MP0003566_abnormal_cell_adhesion2.00632801
15MP0004858_abnormal_nervous_system1.84477511
16MP0010234_abnormal_vibrissa_follicle1.82587962
17MP0003045_fibrosis1.75272778
18MP0008961_abnormal_basal_metabolism1.71556991
19MP0003091_abnormal_cell_migration1.70280761
20MP0004185_abnormal_adipocyte_glucose1.69389379
21MP0003329_amyloid_beta_deposits1.68871193
22* MP0000733_abnormal_muscle_development1.68362917
23MP0003385_abnormal_body_wall1.61680385
24MP0000751_myopathy1.59387396
25MP0001849_ear_inflammation1.58120233
26MP0009053_abnormal_anal_canal1.54921295
27MP0009780_abnormal_chondrocyte_physiolo1.52647460
28MP0004510_myositis1.52595007
29MP0003283_abnormal_digestive_organ1.50484062
30MP0010352_gastrointestinal_tract_polyps1.47422466
31MP0000534_abnormal_ureter_morphology1.46191957
32MP0000569_abnormal_digit_pigmentation1.40919408
33MP0010368_abnormal_lymphatic_system1.38475459
34MP0001299_abnormal_eye_distance/1.38413294
35MP0005508_abnormal_skeleton_morphology1.37153699
36MP0000537_abnormal_urethra_morphology1.30571202
37MP0005257_abnormal_intraocular_pressure1.28626707
38MP0000767_abnormal_smooth_muscle1.28481458
39MP0009384_cardiac_valve_regurgitation1.27592765
40MP0003115_abnormal_respiratory_system1.25531979
41MP0002896_abnormal_bone_mineralization1.23090673
42MP0008260_abnormal_autophagy1.22874465
43MP0000428_abnormal_craniofacial_morphol1.21969181
44MP0003453_abnormal_keratinocyte_physiol1.20316071
45* MP0004087_abnormal_muscle_fiber1.20047048
46MP0003635_abnormal_synaptic_transmissio1.19284511
47MP0002108_abnormal_muscle_morphology1.16716882
48MP0003690_abnormal_glial_cell1.16677737
49MP0005023_abnormal_wound_healing1.15910557
50MP0002925_abnormal_cardiovascular_devel1.15706514
51MP0004233_abnormal_muscle_weight1.15542897
52MP0004484_altered_response_of1.13227108
53MP0004145_abnormal_muscle_electrophysio1.12845143
54MP0004084_abnormal_cardiac_muscle1.12191795
55MP0009278_abnormal_bone_marrow1.12115674
56MP0006138_congestive_heart_failure1.10374829
57MP0005375_adipose_tissue_phenotype1.08504449
58MP0010630_abnormal_cardiac_muscle1.08107448
59MP0000003_abnormal_adipose_tissue1.07887210
60MP0005670_abnormal_white_adipose1.07001996
61MP0005167_abnormal_blood-brain_barrier1.04253032
62MP0003935_abnormal_craniofacial_develop1.04079888
63MP0003436_decreased_susceptibility_to1.03875482
64MP0003828_pulmonary_edema1.00507365
65MP0002060_abnormal_skin_morphology1.00409292
66MP0010030_abnormal_orbit_morphology0.99761175
67MP0000566_synostosis0.98672662
68MP0003191_abnormal_cellular_cholesterol0.97692519
69MP0002133_abnormal_respiratory_system0.97369079
70MP0005388_respiratory_system_phenotype0.97369079
71MP0003634_abnormal_glial_cell0.96800142
72MP0000678_abnormal_parathyroid_gland0.95839776
73MP0003942_abnormal_urinary_system0.94605250
74MP0002295_abnormal_pulmonary_circulatio0.94558444
75MP0001879_abnormal_lymphatic_vessel0.94421595
76MP0004947_skin_inflammation0.94252315
77MP0003172_abnormal_lysosome_physiology0.94139909
78MP0004130_abnormal_muscle_cell0.94083262
79MP0005058_abnormal_lysosome_morphology0.94035646
80MP0005666_abnormal_adipose_tissue0.91928449
81MP0000750_abnormal_muscle_regeneration0.91775233
82MP0002932_abnormal_joint_morphology0.91305712
83MP0002249_abnormal_larynx_morphology0.90093463
84MP0002998_abnormal_bone_remodeling0.89992370
85MP0002089_abnormal_postnatal_growth/wei0.89640673
86MP0001348_abnormal_lacrimal_gland0.89336872
87MP0002168_other_aberrant_phenotype0.88207624
88MP0002877_abnormal_melanocyte_morpholog0.88167186
89MP0003075_altered_response_to0.87699452
90MP0009840_abnormal_foam_cell0.86928741
91MP0002933_joint_inflammation0.86721660
92MP0008569_lethality_at_weaning0.85908040
93MP0001614_abnormal_blood_vessel0.84385494
94MP0005248_abnormal_Harderian_gland0.84034521
95MP0005451_abnormal_body_composition0.83894331
96MP0009250_abnormal_appendicular_skeleto0.83675204
97MP0004885_abnormal_endolymph0.83424342
98MP0003879_abnormal_hair_cell0.83416481
99MP0000266_abnormal_heart_morphology0.83224468
100MP0003755_abnormal_palate_morphology0.83204396
101MP0002234_abnormal_pharynx_morphology0.82864061
102MP0005595_abnormal_vascular_smooth0.82594816
103MP0000747_muscle_weakness0.82339590
104MP0002909_abnormal_adrenal_gland0.81267334
105MP0002796_impaired_skin_barrier0.80737739
106MP0003119_abnormal_digestive_system0.80378619
107MP0002063_abnormal_learning/memory/cond0.79565015
108* MP0002128_abnormal_blood_circulation0.78851379
109MP0005621_abnormal_cell_physiology0.78850664
110* MP0000759_abnormal_skeletal_muscle0.78425155
111MP0001915_intracranial_hemorrhage0.77547441
112* MP0002116_abnormal_craniofacial_bone0.77518329
113MP0005187_abnormal_penis_morphology0.76670081
114MP0000858_altered_metastatic_potential0.76479081
115MP0004270_analgesia0.76021019
116MP0005367_renal/urinary_system_phenotyp0.75517267
117MP0000516_abnormal_urinary_system0.75517267
118MP0001502_abnormal_circadian_rhythm0.75047838
119MP0001851_eye_inflammation0.74537077
120MP0000762_abnormal_tongue_morphology0.73037042
121MP0000920_abnormal_myelination0.73016961
122MP0001542_abnormal_bone_strength0.72665563
123MP0001533_abnormal_skeleton_physiology0.71545055
124MP0005423_abnormal_somatic_nervous0.71166592
125* MP0000432_abnormal_head_morphology0.71088780
126MP0009672_abnormal_birth_weight0.71008371
127MP0005390_skeleton_phenotype0.68774533
128MP0002115_abnormal_skeleton_extremities0.68714951
129MP0005369_muscle_phenotype0.67812285
130MP0001784_abnormal_fluid_regulation0.67533301
131MP0001544_abnormal_cardiovascular_syste0.65242697
132MP0005385_cardiovascular_system_phenoty0.65242697

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.52285396
2Cerebral aneurysm (HP:0004944)4.24663357
3* Shallow orbits (HP:0000586)3.99494470
4Premature rupture of membranes (HP:0001788)3.82724753
5Broad metatarsal (HP:0001783)3.52890656
6* Obstructive sleep apnea (HP:0002870)3.41312982
7Aortic dissection (HP:0002647)3.23093641
8Ankle contracture (HP:0006466)3.10156569
9Aortic aneurysm (HP:0004942)3.04654250
10Dilatation of the ascending aorta (HP:0005111)2.91452963
11* Mitral valve prolapse (HP:0001634)2.83931991
12Bladder diverticulum (HP:0000015)2.80622281
13Arterial tortuosity (HP:0005116)2.78152088
14Atrophic scars (HP:0001075)2.76176221
15Vascular tortuosity (HP:0004948)2.67532355
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.59420270
17Short 4th metacarpal (HP:0010044)2.59420270
18Broad face (HP:0000283)2.52702720
19Increased connective tissue (HP:0009025)2.49819037
20Ulnar bowing (HP:0003031)2.47829824
21Hyperacusis (HP:0010780)2.40770194
22Abnormality of the fingertips (HP:0001211)2.35222674
23Aneurysm (HP:0002617)2.34439448
24Fragile skin (HP:0001030)2.24153899
25* Genu recurvatum (HP:0002816)2.24140353
26Type 1 muscle fiber predominance (HP:0003803)2.24048772
27Striae distensae (HP:0001065)2.22418134
28Abnormality of the 4th metacarpal (HP:0010012)2.21629240
29Wrist flexion contracture (HP:0001239)2.21037614
30Peritonitis (HP:0002586)2.18525635
31Increased variability in muscle fiber diameter (HP:0003557)2.16180402
32Overgrowth (HP:0001548)2.15943561
33Deviation of the hallux (HP:0010051)2.12273813
34Achilles tendon contracture (HP:0001771)2.12053054
35Distal upper limb amyotrophy (HP:0007149)2.10764451
36Upper limb amyotrophy (HP:0009129)2.10764451
37Bronchomalacia (HP:0002780)2.09881254
38Neurofibrillary tangles (HP:0002185)2.07724065
39Bowel diverticulosis (HP:0005222)2.07563045
40Biconcave vertebral bodies (HP:0004586)2.06483810
41Segmental peripheral demyelination/remyelination (HP:0003481)2.05746582
42Abnormality of the distal phalanx of the thumb (HP:0009617)2.02925814
43Hallux valgus (HP:0001822)2.02442477
44Mildly elevated creatine phosphokinase (HP:0008180)2.02335749
45Dysmetric saccades (HP:0000641)2.01718193
46Cerebral inclusion bodies (HP:0100314)2.00895294
47Action tremor (HP:0002345)2.00307169
48Long palpebral fissure (HP:0000637)1.99401000
49Soft skin (HP:0000977)1.97389726
50Renal duplication (HP:0000075)1.96487325
51Thin bony cortex (HP:0002753)1.96377040
52Genetic anticipation (HP:0003743)1.96106658
53Vertebral compression fractures (HP:0002953)1.95951541
54Supranuclear gaze palsy (HP:0000605)1.93839167
55Mild short stature (HP:0003502)1.93668374
56Urethral obstruction (HP:0000796)1.92440666
57Spinal rigidity (HP:0003306)1.92361179
58Macroorchidism (HP:0000053)1.90433866
59Abnormality of skeletal muscle fiber size (HP:0012084)1.89685113
60Premature skin wrinkling (HP:0100678)1.88797800
61Lower limb amyotrophy (HP:0007210)1.87082240
62Flat cornea (HP:0007720)1.86835497
63Long eyelashes (HP:0000527)1.85503204
64Scapular winging (HP:0003691)1.85365683
65* Hyperextensible skin (HP:0000974)1.83638535
66Neoplasm of the heart (HP:0100544)1.83212319
67Buphthalmos (HP:0000557)1.81880377
68* Arnold-Chiari malformation (HP:0002308)1.81284248
69Vertebral arch anomaly (HP:0008438)1.80932959
70Blue sclerae (HP:0000592)1.80490473
71Spinal cord lesions (HP:0100561)1.80406935
72Syringomyelia (HP:0003396)1.80406935
73Abnormality of the Achilles tendon (HP:0005109)1.79862938
74Difficulty running (HP:0009046)1.79776385
75Milia (HP:0001056)1.79473834
76Cervical subluxation (HP:0003308)1.79249471
77* Disproportionate tall stature (HP:0001519)1.78993254
78Mitral regurgitation (HP:0001653)1.78984450
79Increased density of long bones (HP:0006392)1.78079558
80Turricephaly (HP:0000262)1.77395361
81Onion bulb formation (HP:0003383)1.76663134
82Hypoventilation (HP:0002791)1.76055555
83Distal lower limb amyotrophy (HP:0008944)1.75538100
84Spondylolisthesis (HP:0003302)1.75482247
85Persistence of primary teeth (HP:0006335)1.75224681
86Follicular hyperkeratosis (HP:0007502)1.74670221
87Lymphangioma (HP:0100764)1.72681775
88Abnormality of the lower motor neuron (HP:0002366)1.72107756
89Broad ribs (HP:0000885)1.71695488
90Subacute progressive viral hepatitis (HP:0006572)1.71640141
91Hypoplasia of the iris (HP:0007676)1.70688159
92Renovascular hypertension (HP:0100817)1.69972643
93* Pointed chin (HP:0000307)1.69768658
94Broad thumb (HP:0011304)1.69619389
95Hemiplegia (HP:0002301)1.69608935
96Hematochezia (HP:0002573)1.69575894
97Centrally nucleated skeletal muscle fibers (HP:0003687)1.67643063
98Hyporeflexia of lower limbs (HP:0002600)1.66719968
99Slender build (HP:0001533)1.65983766
100Enlarged penis (HP:0000040)1.65678086
101Trigonocephaly (HP:0000243)1.65269765
102Ectopia lentis (HP:0001083)1.65268108
103Sudden death (HP:0001699)1.65177119
104Hand muscle atrophy (HP:0009130)1.65144108
105Elfin facies (HP:0004428)1.63818919
106Wormian bones (HP:0002645)1.63697045
107Ankyloglossia (HP:0010296)1.63387169
108Advanced eruption of teeth (HP:0006288)1.63225516
109Round ear (HP:0100830)1.62845544
110Hammertoe (HP:0001765)1.61444092
111* Joint laxity (HP:0001388)1.60928264
112Osteolytic defects of the hand bones (HP:0009699)1.60914248
113Osteolytic defects of the phalanges of the hand (HP:0009771)1.60914248
114* Camptodactyly of toe (HP:0001836)1.59966906
115Asymmetry of the thorax (HP:0001555)1.58979096
116* Dislocated radial head (HP:0003083)1.58549375
117Hip contracture (HP:0003273)1.58225871
118Aplasia involving bones of the upper limbs (HP:0009823)1.57998938
119Aplasia of the phalanges of the hand (HP:0009802)1.57998938
120Aplasia involving bones of the extremities (HP:0009825)1.57998938
121Difficulty climbing stairs (HP:0003551)1.57733607
122Hypercortisolism (HP:0001578)1.57299784
123Sparse lateral eyebrow (HP:0005338)1.57267496
124Stridor (HP:0010307)1.57047237
125Insomnia (HP:0100785)1.56724356
126Precocious puberty (HP:0000826)1.55179171
127Overriding aorta (HP:0002623)1.54643248
128Abnormality of the phalanges of the hallux (HP:0010057)1.54573496
129Rapidly progressive (HP:0003678)1.54473482
130Abnormality of dentin (HP:0010299)1.54167981
131* Narrow palate (HP:0000189)1.53603147
132Neonatal short-limb short stature (HP:0008921)1.52700490
133Venous abnormality (HP:0002624)1.52482382
134Bundle branch block (HP:0011710)1.52040147
135Distal lower limb muscle weakness (HP:0009053)1.51476180
136Abnormality of oral frenula (HP:0000190)1.51188576
137Protruding ear (HP:0000411)1.49169175
138Abnormal ossification of hand bones (HP:0005921)1.48892429
139* Abnormality of the radial head (HP:0003995)1.48781623
140Decreased motor nerve conduction velocity (HP:0003431)1.48361086
141Diplopia (HP:0000651)1.47689587
142Abnormality of binocular vision (HP:0011514)1.47689587

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.83085713
2RIPK12.75789351
3PKN22.46508198
4SMG12.45863643
5PDGFRA2.28770617
6DMPK2.28039065
7CDK122.22330504
8TTN2.18605509
9LATS22.16691221
10LATS12.15413258
11EEF2K2.09557478
12PRKD32.08524454
13MAP3K92.07035645
14TGFBR22.00919366
15TAOK11.87537579
16CAMK1G1.79963872
17DDR21.78427265
18TYRO31.75935369
19PTK61.69548098
20PAK61.57544368
21MAP3K101.56229650
22KSR21.51831305
23CAMK1D1.49550974
24MAP3K131.46564993
25EPHB21.41463948
26CAMKK11.41199756
27EPHB11.35343885
28ICK1.34252776
29STK381.34075689
30SIK21.24884357
31RET1.24823064
32PTK21.24300381
33SIK11.22943902
34PRKCH1.22604745
35ALK1.21637598
36EPHA31.17135223
37BMX1.13480515
38DAPK21.13204728
39EPHA41.13139940
40FER1.11893434
41PDGFRB1.11752574
42PRKD21.10874264
43MAP3K21.07881160
44MTOR1.06255155
45ERN11.05518103
46MARK21.02226996
47NTRK11.00986029
48MAP3K31.00357338
49NTRK31.00016374
50PAK40.99801784
51STK110.96731055
52NTRK20.94078035
53PAK20.93670282
54MAP3K70.93631219
55FGFR10.92552759
56UHMK10.90741677
57STK100.90279970
58FGFR20.86030577
59FGFR40.84138721
60FGFR30.83891408
61SGK30.83603026
62IRAK30.79841373
63CDK60.78013086
64KSR10.75850380
65ZAP700.75346969
66MAPK70.74825966
67RPS6KC10.74254565
68RPS6KL10.74254565
69CAMK40.73766288
70PRKD10.73583804
71MAP3K60.72556901
72MOS0.71829953
73RIPK40.71366827
74TAOK20.70409714
75MINK10.70201192
76MARK10.68293904
77ARAF0.68184946
78PTK2B0.67517564
79LRRK20.66650181
80MAP3K40.65135398
81WNK10.64580193
82JAK10.63574404
83CAMKK20.62281769
84SIK30.62015742
85SGK2230.61782193
86SGK4940.61782193
87PRPF4B0.60528033
88PAK30.58034881
89PHKG20.55786265
90PHKG10.55786265
91FES0.54986220
92CDC42BPA0.54687570
93MAP3K110.54214611
94MAPK100.53768087
95CDK50.53582713
96RPS6KA60.53232202
97MAP3K10.53108541
98RPS6KA20.52900207
99DYRK1B0.52714652
100CDK90.51873072
101SGK20.51747388
102BRD40.51664828
103HCK0.50001512
104ROCK20.49107127
105MAP2K40.47760376
106STK30.47497718
107IRAK20.47497346
108EPHA20.46939651
109ROCK10.46910233
110LMTK20.46196071
111MELK0.46190454
112TNK20.45423572
113CSK0.44532391
114PDPK10.44505550
115MAPK120.43071075
116PRKG20.42468696
117FYN0.41636929
118JAK30.40640781
119CDK150.40349883
120JAK20.39280720
121TRPM70.38891789
122HIPK20.38506861
123MAP2K30.37700484
124MAP4K10.37114703
125CAMK10.36323617
126SRC0.36262468
127PDK10.36256013
128MAPK80.35545381
129ERBB20.35393397
130SGK10.34614357

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65888425
2Focal adhesion_Homo sapiens_hsa045101.50990941
3Adherens junction_Homo sapiens_hsa045201.43223476
4Dilated cardiomyopathy_Homo sapiens_hsa054141.43030827
5ECM-receptor interaction_Homo sapiens_hsa045121.42327523
6Long-term potentiation_Homo sapiens_hsa047201.38716368
7Prion diseases_Homo sapiens_hsa050201.37455340
8Proteoglycans in cancer_Homo sapiens_hsa052051.36928419
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.36685397
10Chronic myeloid leukemia_Homo sapiens_hsa052201.35099106
11Glioma_Homo sapiens_hsa052141.34249318
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33677297
13Estrogen signaling pathway_Homo sapiens_hsa049151.31389790
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30569710
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28503983
16GnRH signaling pathway_Homo sapiens_hsa049121.27759719
17Dorso-ventral axis formation_Homo sapiens_hsa043201.26934925
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24977868
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24472102
20Hippo signaling pathway_Homo sapiens_hsa043901.21562198
21Renal cell carcinoma_Homo sapiens_hsa052111.21112139
22VEGF signaling pathway_Homo sapiens_hsa043701.20270773
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19982120
24Axon guidance_Homo sapiens_hsa043601.19378752
25Amoebiasis_Homo sapiens_hsa051461.18321134
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18294878
27Gastric acid secretion_Homo sapiens_hsa049711.17955028
28Neurotrophin signaling pathway_Homo sapiens_hsa047221.17496491
29mTOR signaling pathway_Homo sapiens_hsa041501.15315728
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14606068
31Renin secretion_Homo sapiens_hsa049241.14593910
32Endometrial cancer_Homo sapiens_hsa052131.14589817
33Oxytocin signaling pathway_Homo sapiens_hsa049211.13005703
34Type II diabetes mellitus_Homo sapiens_hsa049301.12840487
35Circadian entrainment_Homo sapiens_hsa047131.12779528
36Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11632233
37Basal cell carcinoma_Homo sapiens_hsa052171.10437541
38Salivary secretion_Homo sapiens_hsa049701.10224756
39Rap1 signaling pathway_Homo sapiens_hsa040151.10135245
40Gap junction_Homo sapiens_hsa045401.09835252
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09317525
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08179664
43Colorectal cancer_Homo sapiens_hsa052101.07382211
44Cholinergic synapse_Homo sapiens_hsa047251.06862649
45Notch signaling pathway_Homo sapiens_hsa043301.06799857
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.06555950
47Central carbon metabolism in cancer_Homo sapiens_hsa052301.06190572
48Glutamatergic synapse_Homo sapiens_hsa047241.05463578
49Melanogenesis_Homo sapiens_hsa049161.05053318
50ErbB signaling pathway_Homo sapiens_hsa040121.04573982
51Pancreatic cancer_Homo sapiens_hsa052121.04477488
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03366837
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02918302
54B cell receptor signaling pathway_Homo sapiens_hsa046621.02891172
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01518586
56Long-term depression_Homo sapiens_hsa047301.01106682
57Thyroid cancer_Homo sapiens_hsa052161.01103134
58Nitrogen metabolism_Homo sapiens_hsa009101.00772097
59Inositol phosphate metabolism_Homo sapiens_hsa005620.99817774
60Osteoclast differentiation_Homo sapiens_hsa043800.99803177
61MAPK signaling pathway_Homo sapiens_hsa040100.97822245
62Amphetamine addiction_Homo sapiens_hsa050310.97756014
63Olfactory transduction_Homo sapiens_hsa047400.97568554
64MicroRNAs in cancer_Homo sapiens_hsa052060.97271531
65TGF-beta signaling pathway_Homo sapiens_hsa043500.96832284
66Hedgehog signaling pathway_Homo sapiens_hsa043400.96441643
67Platelet activation_Homo sapiens_hsa046110.95976584
68cAMP signaling pathway_Homo sapiens_hsa040240.95138601
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95100124
70Endocytosis_Homo sapiens_hsa041440.94684157
71Dopaminergic synapse_Homo sapiens_hsa047280.94208000
72Non-small cell lung cancer_Homo sapiens_hsa052230.93226338
73Cocaine addiction_Homo sapiens_hsa050300.93138070
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91785803
75AMPK signaling pathway_Homo sapiens_hsa041520.91400798
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.91182840
77Wnt signaling pathway_Homo sapiens_hsa043100.90942022
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90807128
79Small cell lung cancer_Homo sapiens_hsa052220.89211516
80Viral myocarditis_Homo sapiens_hsa054160.88690220
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88541230
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87176537
83Choline metabolism in cancer_Homo sapiens_hsa052310.85706441
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84919335
85Tight junction_Homo sapiens_hsa045300.83927638
86Prolactin signaling pathway_Homo sapiens_hsa049170.83542656
87Toxoplasmosis_Homo sapiens_hsa051450.82840900
88Morphine addiction_Homo sapiens_hsa050320.82509323
89Insulin resistance_Homo sapiens_hsa049310.82237867
90Bladder cancer_Homo sapiens_hsa052190.81896065
91Other glycan degradation_Homo sapiens_hsa005110.81192203
92Insulin secretion_Homo sapiens_hsa049110.79648465
93Acute myeloid leukemia_Homo sapiens_hsa052210.79632394
94Protein digestion and absorption_Homo sapiens_hsa049740.78714921
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78228444
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76533647
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.76445730
98Pathways in cancer_Homo sapiens_hsa052000.76340639
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75841054
100T cell receptor signaling pathway_Homo sapiens_hsa046600.75059408
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.74433955
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74127611
103Hepatitis B_Homo sapiens_hsa051610.74040871
104Chemokine signaling pathway_Homo sapiens_hsa040620.73061023
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.72026174
106Insulin signaling pathway_Homo sapiens_hsa049100.71926283
107Prostate cancer_Homo sapiens_hsa052150.71736516
108Ras signaling pathway_Homo sapiens_hsa040140.71577574
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71429311
110TNF signaling pathway_Homo sapiens_hsa046680.69452494
111GABAergic synapse_Homo sapiens_hsa047270.68790740
112Synaptic vesicle cycle_Homo sapiens_hsa047210.68316665
113FoxO signaling pathway_Homo sapiens_hsa040680.68117201
114HIF-1 signaling pathway_Homo sapiens_hsa040660.67563012
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66358353
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64706923
117Lysine degradation_Homo sapiens_hsa003100.61651809

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