ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.34180059
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.16911648
3	protein localization to cilium (GO:0061512)	3.82345208
4	neural tube formation (GO:0001841)	3.69985070
5	detection of light stimulus involved in visual perception (GO:0050908)	3.69572774
6	detection of light stimulus involved in sensory perception (GO:0050962)	3.69572774
7	L-fucose catabolic process (GO:0042355)	3.64429694
8	fucose catabolic process (GO:0019317)	3.64429694
9	L-fucose metabolic process (GO:0042354)	3.64429694
10	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.60696962
11	epithelial cilium movement (GO:0003351)	3.55175151
12	establishment of protein localization to Golgi (GO:0072600)	3.43003399
13	indole-containing compound catabolic process (GO:0042436)	3.40680074
14	indolalkylamine catabolic process (GO:0046218)	3.40680074
15	tryptophan catabolic process (GO:0006569)	3.40680074
16	regulation of cilium movement (GO:0003352)	3.38561971
17	indolalkylamine metabolic process (GO:0006586)	3.35686387
18	negative regulation of protein localization to cell surface (GO:2000009)	3.33624289
19	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.27482891
20	presynaptic membrane assembly (GO:0097105)	3.27401900
21	photoreceptor cell maintenance (GO:0045494)	3.18189785
22	cellular ketone body metabolic process (GO:0046950)	3.17494403
23	pyrimidine nucleobase catabolic process (GO:0006208)	3.08388050
24	DNA double-strand break processing (GO:0000729)	3.06529870
25	axoneme assembly (GO:0035082)	3.06505071
26	cilium or flagellum-dependent cell motility (GO:0001539)	3.04287579
27	nonmotile primary cilium assembly (GO:0035058)	3.03793364
28	transmission of nerve impulse (GO:0019226)	3.02341439
29	platelet dense granule organization (GO:0060155)	3.02128280
30	regulation of memory T cell differentiation (GO:0043380)	3.00386920
31	cilium organization (GO:0044782)	2.96102063
32	cilium movement (GO:0003341)	2.95664888
33	cilium morphogenesis (GO:0060271)	2.92670109
34	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.89790240
35	cilium assembly (GO:0042384)	2.89144266
36	adaptation of signaling pathway (GO:0023058)	2.88382059
37	ketone body metabolic process (GO:1902224)	2.87762675
38	neuronal action potential (GO:0019228)	2.85044883
39	tryptophan metabolic process (GO:0006568)	2.83186590
40	presynaptic membrane organization (GO:0097090)	2.82728347
41	regulation of action potential (GO:0098900)	2.82416713
42	reflex (GO:0060004)	2.81045485
43	gamma-aminobutyric acid transport (GO:0015812)	2.80043899
44	nucleobase catabolic process (GO:0046113)	2.79926006
45	sulfation (GO:0051923)	2.78927935
46	positive regulation of developmental pigmentation (GO:0048087)	2.78457000
47	limb bud formation (GO:0060174)	2.76927887
48	somite development (GO:0061053)	2.76561458
49	response to pheromone (GO:0019236)	2.73511236
50	protein polyglutamylation (GO:0018095)	2.72633128
51	regulation of collateral sprouting (GO:0048670)	2.71033455
52	protein K11-linked deubiquitination (GO:0035871)	2.70737859
53	respiratory chain complex IV assembly (GO:0008535)	2.69735704
54	centriole replication (GO:0007099)	2.69553693
55	postsynaptic membrane organization (GO:0001941)	2.68969365
56	kynurenine metabolic process (GO:0070189)	2.68752711
57	regulation of pigment cell differentiation (GO:0050932)	2.68492795
58	C4-dicarboxylate transport (GO:0015740)	2.68485119
59	cornea development in camera-type eye (GO:0061303)	2.67724797
60	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.66632939
61	negative regulation of mast cell activation (GO:0033004)	2.65338599
62	indole-containing compound metabolic process (GO:0042430)	2.64329685
63	kidney morphogenesis (GO:0060993)	2.63494635
64	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.62188036
65	NADH dehydrogenase complex assembly (GO:0010257)	2.62188036
66	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.62188036
67	protein complex biogenesis (GO:0070271)	2.61402201
68	tachykinin receptor signaling pathway (GO:0007217)	2.60283709
69	protein targeting to Golgi (GO:0000042)	2.59974443
70	DNA deamination (GO:0045006)	2.59570258
71	adenosine metabolic process (GO:0046085)	2.58824979
72	piRNA metabolic process (GO:0034587)	2.58101853
73	preassembly of GPI anchor in ER membrane (GO:0016254)	2.56126620
74	regulation of sarcomere organization (GO:0060297)	2.55891557
75	protein localization to Golgi apparatus (GO:0034067)	2.54819717
76	photoreceptor cell development (GO:0042461)	2.53468059
77	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.52215467
78	serotonin metabolic process (GO:0042428)	2.50832196
79	negative regulation of systemic arterial blood pressure (GO:0003085)	2.50057117
80	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.49674236
81	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.49674236
82	regulation of translation, ncRNA-mediated (GO:0045974)	2.49674236
83	glutamate receptor signaling pathway (GO:0007215)	2.49655052
84	sympathetic nervous system development (GO:0048485)	2.49393586
85	spinal cord motor neuron differentiation (GO:0021522)	2.49147996
86	serotonin receptor signaling pathway (GO:0007210)	2.49085739
87	intraciliary transport (GO:0042073)	2.47670424
88	cytochrome complex assembly (GO:0017004)	2.46585056
89	synaptic transmission, cholinergic (GO:0007271)	2.45912525
90	regulation of meiosis I (GO:0060631)	2.45795376
91	regulation of hexokinase activity (GO:1903299)	2.45747986
92	regulation of glucokinase activity (GO:0033131)	2.45747986
93	protein K63-linked deubiquitination (GO:0070536)	2.45666890
94	membrane depolarization during action potential (GO:0086010)	2.44263547
95	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.42508945
96	cAMP catabolic process (GO:0006198)	2.41410167
97	primary amino compound metabolic process (GO:1901160)	2.40962178
98	neuronal action potential propagation (GO:0019227)	2.40158175
99	signal peptide processing (GO:0006465)	2.38972158
100	behavioral response to ethanol (GO:0048149)	2.38888431

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.44115973
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.34056892
3	VDR_22108803_ChIP-Seq_LS180_Human	3.06267536
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.83297823
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.80678082
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.78702362
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.72407812
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.67369094
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.63336704
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.54923863
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.49333494
12	P300_19829295_ChIP-Seq_ESCs_Human	2.27191983
13	FUS_26573619_Chip-Seq_HEK293_Human	2.27023074
14	EWS_26573619_Chip-Seq_HEK293_Human	2.26329782
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.25661251
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.22742850
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11905178
18	ER_23166858_ChIP-Seq_MCF-7_Human	2.05786745
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.98391028
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.87308192
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85429005
22	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.84550388
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.83831064
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.81175543
25	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.79214581
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.76977577
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70794586
28	BCAT_22108803_ChIP-Seq_LS180_Human	1.68400092
29	STAT3_23295773_ChIP-Seq_U87_Human	1.66114948
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.64854392
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.64854392
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64629870
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.56863135
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.56833296
35	AR_25329375_ChIP-Seq_VCAP_Human	1.56286298
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56184686
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.56184686
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.52908448
39	TCF4_23295773_ChIP-Seq_U87_Human	1.52216726
40	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.50691093
41	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.50527555
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.50496094
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.49877045
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45122561
45	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44322599
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.44073687
47	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.43346655
48	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.42944093
49	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.41353677
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40810684
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.40563187
52	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.37446972
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.36422164
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.34110239
55	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.31903456
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.31202098
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30588222
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30515358
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30515358
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30076700
61	P53_22387025_ChIP-Seq_ESCs_Mouse	1.29097253
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.28725746
63	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.26564504
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26559366
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.26081397
66	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.25819195
67	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25171127
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23008049
69	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.19566297
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19167571
71	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.19046506
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17751751
73	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.16481597
74	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.15467830
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13848171
76	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.13002974
77	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.12216335
78	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.11813906
79	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11353191
80	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.10586661
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.10059362
82	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09635262
83	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08566545
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08566545
85	P300_18555785_Chip-Seq_ESCs_Mouse	1.08083480
86	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.07692434
87	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06933302
88	TP53_16413492_ChIP-PET_HCT116_Human	1.05228020
89	CDX2_22108803_ChIP-Seq_LS180_Human	1.05116000
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05025220
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.02942796
92	KDM2B_26808549_Chip-Seq_REH_Human	1.01487650
93	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.00893112
94	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00629919
95	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.99938270
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99854453
97	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.99461993
98	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.98919480
99	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.98676472
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98362094

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.02920919
2	MP0003880_abnormal_central_pattern	2.95891065
3	MP0000569_abnormal_digit_pigmentation	2.74536294
4	MP0008877_abnormal_DNA_methylation	2.69564236
5	MP0001968_abnormal_touch/_nociception	2.44262983
6	MP0005551_abnormal_eye_electrophysiolog	2.43979033
7	MP0003787_abnormal_imprinting	2.25344030
8	MP0002736_abnormal_nociception_after	2.25262892
9	MP0009046_muscle_twitch	2.19530995
10	MP0004142_abnormal_muscle_tone	2.17170148
11	MP0004885_abnormal_endolymph	2.03219997
12	MP0005646_abnormal_pituitary_gland	1.96951673
13	MP0000372_irregular_coat_pigmentation	1.96772928
14	MP0002102_abnormal_ear_morphology	1.94415044
15	MP0010386_abnormal_urinary_bladder	1.94353115
16	MP0006072_abnormal_retinal_apoptosis	1.91990341
17	MP0002837_dystrophic_cardiac_calcinosis	1.90718850
18	MP0009745_abnormal_behavioral_response	1.89024119
19	MP0002735_abnormal_chemical_nociception	1.86623841
20	MP0001486_abnormal_startle_reflex	1.78485128
21	MP0005253_abnormal_eye_physiology	1.78054152
22	MP0002638_abnormal_pupillary_reflex	1.74784118
23	MP0002876_abnormal_thyroid_physiology	1.74694900
24	MP0005645_abnormal_hypothalamus_physiol	1.71731016
25	MP0002272_abnormal_nervous_system	1.68863616
26	MP0001501_abnormal_sleep_pattern	1.68268754
27	MP0008872_abnormal_physiological_respon	1.67869983
28	MP0004043_abnormal_pH_regulation	1.65194421
29	MP0006276_abnormal_autonomic_nervous	1.62295707
30	MP0001984_abnormal_olfaction	1.60863687
31	MP0002234_abnormal_pharynx_morphology	1.57937065
32	MP0005084_abnormal_gallbladder_morpholo	1.57824702
33	MP0003136_yellow_coat_color	1.56580676
34	MP0000631_abnormal_neuroendocrine_gland	1.54726163
35	MP0006292_abnormal_olfactory_placode	1.53128217
36	MP0003646_muscle_fatigue	1.51437493
37	MP0001970_abnormal_pain_threshold	1.51027105
38	MP0002938_white_spotting	1.50245992
39	MP0002572_abnormal_emotion/affect_behav	1.49001305
40	MP0002064_seizures	1.46839655
41	MP0001529_abnormal_vocalization	1.44380024
42	MP0003635_abnormal_synaptic_transmissio	1.39589886
43	MP0004147_increased_porphyrin_level	1.39431046
44	MP0002733_abnormal_thermal_nociception	1.38597878
45	MP0004215_abnormal_myocardial_fiber	1.35142412
46	MP0005174_abnormal_tail_pigmentation	1.34422158
47	MP0000383_abnormal_hair_follicle	1.33730272
48	MP0004145_abnormal_muscle_electrophysio	1.30622671
49	MP0002067_abnormal_sensory_capabilities	1.29583952
50	MP0002751_abnormal_autonomic_nervous	1.26350887
51	MP0002557_abnormal_social/conspecific_i	1.24824984
52	MP0004133_heterotaxia	1.23821562
53	MP0000427_abnormal_hair_cycle	1.23326093
54	MP0001485_abnormal_pinna_reflex	1.21999318
55	MP0008875_abnormal_xenobiotic_pharmacok	1.19270598
56	MP0002063_abnormal_learning/memory/cond	1.17545345
57	MP0002184_abnormal_innervation	1.16395623
58	MP0004742_abnormal_vestibular_system	1.15709946
59	MP0003121_genomic_imprinting	1.15339521
60	MP0002095_abnormal_skin_pigmentation	1.14366133
61	MP0004924_abnormal_behavior	1.13312117
62	MP0005386_behavior/neurological_phenoty	1.13312117
63	MP0002734_abnormal_mechanical_nocicepti	1.12169038
64	MP0003890_abnormal_embryonic-extraembry	1.11426890
65	MP0005423_abnormal_somatic_nervous	1.10000535
66	MP0005085_abnormal_gallbladder_physiolo	1.09992253
67	MP0000647_abnormal_sebaceous_gland	1.07206901
68	MP0003252_abnormal_bile_duct	1.06956518
69	MP0008995_early_reproductive_senescence	1.03581379
70	MP0003011_delayed_dark_adaptation	1.03019148
71	MP0002928_abnormal_bile_duct	1.02317132
72	MP0005187_abnormal_penis_morphology	0.99254829
73	MP0001986_abnormal_taste_sensitivity	0.97529038
74	MP0000778_abnormal_nervous_system	0.97384889
75	MP0005410_abnormal_fertilization	0.96914926
76	MP0005195_abnormal_posterior_eye	0.94205184
77	MP0002752_abnormal_somatic_nervous	0.92490977
78	MP0008057_abnormal_DNA_replication	0.90870025
79	MP0003283_abnormal_digestive_organ	0.89077389
80	MP0000026_abnormal_inner_ear	0.88517011
81	MP0005379_endocrine/exocrine_gland_phen	0.88151921
82	MP0000230_abnormal_systemic_arterial	0.87980811
83	MP0003718_maternal_effect	0.87113926
84	MP0003122_maternal_imprinting	0.86807274
85	MP0001905_abnormal_dopamine_level	0.86288599
86	MP0003698_abnormal_male_reproductive	0.83651429
87	MP0001963_abnormal_hearing_physiology	0.82205658
88	MP0005075_abnormal_melanosome_morpholog	0.82126655
89	MP0004270_analgesia	0.81754863
90	MP0002909_abnormal_adrenal_gland	0.80404689
91	MP0005367_renal/urinary_system_phenotyp	0.79579353
92	MP0000516_abnormal_urinary_system	0.79579353
93	MP0001324_abnormal_eye_pigmentation	0.79418781
94	MP0000955_abnormal_spinal_cord	0.78870050
95	MP0004085_abnormal_heartbeat	0.78485882
96	MP0002822_catalepsy	0.78449566
97	MP0002138_abnormal_hepatobiliary_system	0.78281211
98	MP0001764_abnormal_homeostasis	0.77885073
99	MP0002229_neurodegeneration	0.76462276
100	MP0002163_abnormal_gland_morphology	0.74996358

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.28586832
2	Abnormality of the renal cortex (HP:0011035)	3.91282106
3	Abnormality of midbrain morphology (HP:0002418)	3.91101801
4	Molar tooth sign on MRI (HP:0002419)	3.91101801
5	Pancreatic fibrosis (HP:0100732)	3.90888085
6	True hermaphroditism (HP:0010459)	3.73352964
7	Medial flaring of the eyebrow (HP:0010747)	3.58990837
8	Nephronophthisis (HP:0000090)	3.42083249
9	Renal cortical cysts (HP:0000803)	3.25560281
10	Hyperventilation (HP:0002883)	3.22680472
11	Abnormality of the renal medulla (HP:0100957)	3.20839019
12	Congenital stationary night blindness (HP:0007642)	3.01711219
13	Gait imbalance (HP:0002141)	2.98558165
14	Congenital primary aphakia (HP:0007707)	2.91520218
15	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.90396637
16	Progressive cerebellar ataxia (HP:0002073)	2.86058913
17	Attenuation of retinal blood vessels (HP:0007843)	2.82525781
18	Chronic hepatic failure (HP:0100626)	2.71958863
19	Cystic liver disease (HP:0006706)	2.70565910
20	Nephrogenic diabetes insipidus (HP:0009806)	2.65265204
21	Gaze-evoked nystagmus (HP:0000640)	2.65115351
22	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.62441539
23	Absent/shortened dynein arms (HP:0200106)	2.62441539
24	Tubular atrophy (HP:0000092)	2.57652755
25	Volvulus (HP:0002580)	2.56672230
26	Genetic anticipation (HP:0003743)	2.56598292
27	Polydipsia (HP:0001959)	2.56426980
28	Abnormal drinking behavior (HP:0030082)	2.56426980
29	Congenital sensorineural hearing impairment (HP:0008527)	2.55117365
30	Bony spicule pigmentary retinopathy (HP:0007737)	2.53047418
31	Abolished electroretinogram (ERG) (HP:0000550)	2.50214454
32	Hypothermia (HP:0002045)	2.48544419
33	Genital tract atresia (HP:0001827)	2.43430430
34	Inability to walk (HP:0002540)	2.37415230
35	Thyroid-stimulating hormone excess (HP:0002925)	2.36953189
36	Febrile seizures (HP:0002373)	2.36526325
37	Vaginal atresia (HP:0000148)	2.35667666
38	Type II lissencephaly (HP:0007260)	2.35563329
39	Broad-based gait (HP:0002136)	2.33737315
40	Dialeptic seizures (HP:0011146)	2.33717944
41	Methylmalonic acidemia (HP:0002912)	2.32066664
42	Protruding tongue (HP:0010808)	2.30580580
43	Increased corneal curvature (HP:0100692)	2.29870517
44	Keratoconus (HP:0000563)	2.29870517
45	Progressive inability to walk (HP:0002505)	2.25327084
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.25242959
47	Congenital hepatic fibrosis (HP:0002612)	2.25010996
48	Congenital, generalized hypertrichosis (HP:0004540)	2.24980105
49	Poor coordination (HP:0002370)	2.23667730
50	Hemiparesis (HP:0001269)	2.22262354
51	Focal motor seizures (HP:0011153)	2.21376054
52	Abnormal ciliary motility (HP:0012262)	2.20841247
53	Hypoproteinemia (HP:0003075)	2.18941898
54	Stomach cancer (HP:0012126)	2.18661690
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.17176288
56	Lissencephaly (HP:0001339)	2.15601147
57	Absent speech (HP:0001344)	2.13861437
58	Sclerocornea (HP:0000647)	2.10501817
59	Abnormal respiratory motile cilium morphology (HP:0005938)	2.09727218
60	Abnormal respiratory epithelium morphology (HP:0012253)	2.09727218
61	Intestinal atresia (HP:0011100)	2.08175550
62	Pendular nystagmus (HP:0012043)	2.07783843
63	Anencephaly (HP:0002323)	2.07726155
64	Polyuria (HP:0000103)	2.06574356
65	Furrowed tongue (HP:0000221)	2.04593312
66	Tubulointerstitial nephritis (HP:0001970)	2.01303342
67	Postaxial foot polydactyly (HP:0001830)	2.01219615
68	Thyroiditis (HP:0100646)	1.99064701
69	Tubulointerstitial abnormality (HP:0001969)	1.97280973
70	Limb dystonia (HP:0002451)	1.97059987
71	Focal seizures (HP:0007359)	1.95370361
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.94413967
73	Abnormality of alanine metabolism (HP:0010916)	1.94413967
74	Hyperalaninemia (HP:0003348)	1.94413967
75	Optic nerve hypoplasia (HP:0000609)	1.94000322
76	Male pseudohermaphroditism (HP:0000037)	1.93243457
77	Widely spaced teeth (HP:0000687)	1.91226253
78	Fair hair (HP:0002286)	1.89342192
79	Abnormal respiratory motile cilium physiology (HP:0012261)	1.89087588
80	Decreased central vision (HP:0007663)	1.86651459
81	Absence seizures (HP:0002121)	1.84060348
82	Atonic seizures (HP:0010819)	1.83861063
83	Drooling (HP:0002307)	1.82959372
84	Postaxial hand polydactyly (HP:0001162)	1.82880014
85	Hypoplasia of the fovea (HP:0007750)	1.82467624
86	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.82467624
87	Mitochondrial inheritance (HP:0001427)	1.78850138
88	Increased CSF lactate (HP:0002490)	1.78621328
89	Pachygyria (HP:0001302)	1.77202656
90	Constricted visual fields (HP:0001133)	1.77169384
91	Methylmalonic aciduria (HP:0012120)	1.75904690
92	Colon cancer (HP:0003003)	1.75409470
93	Acute necrotizing encephalopathy (HP:0006965)	1.74983861
94	Progressive macrocephaly (HP:0004481)	1.74627516
95	Abnormal biliary tract physiology (HP:0012439)	1.73704614
96	Bile duct proliferation (HP:0001408)	1.73704614
97	Specific learning disability (HP:0001328)	1.73252663
98	Small hand (HP:0200055)	1.72915046
99	Retinitis pigmentosa (HP:0000510)	1.71071196
100	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.70738633

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.02546854
2	MAP4K2	3.19563235
3	ADRBK2	2.67123423
4	MAPK13	2.50038290
5	CASK	2.43871362
6	BMPR1B	2.38207723
7	WNK3	2.35526753
8	TAOK3	2.24370192
9	CAMKK2	2.02115282
10	INSRR	1.99100234
11	NUAK1	1.96456996
12	TNIK	1.96441117
13	MAP3K4	1.92766233
14	GRK1	1.85671340
15	ZAK	1.84034118
16	ACVR1B	1.83858810
17	MARK1	1.68142588
18	PINK1	1.60121709
19	NTRK3	1.54742423
20	OXSR1	1.52297961
21	WNK4	1.44316310
22	STK39	1.41565445
23	TRIM28	1.30877581
24	EPHA4	1.25551341
25	TLK1	1.22025093
26	PRKCG	1.12731246
27	PRKCE	1.10187518
28	MKNK2	1.10143815
29	ADRBK1	1.08120277
30	PAK3	1.06858502
31	TXK	1.04447338
32	NEK2	0.96952312
33	CSNK1G1	0.95443367
34	MAP2K7	0.93865875
35	CSNK1G2	0.93675939
36	NEK1	0.91758886
37	PLK2	0.91356533
38	CSNK1G3	0.90689527
39	TEC	0.88551439
40	TIE1	0.87534542
41	MUSK	0.86764282
42	CCNB1	0.86739129
43	FGFR2	0.86680589
44	CSNK1A1L	0.85714647
45	ERBB3	0.83298783
46	BCR	0.82073399
47	SIK2	0.80373074
48	STK3	0.77813895
49	TAF1	0.77638219
50	DYRK2	0.76681899
51	MAPKAPK5	0.76040935
52	PNCK	0.75880914
53	STK38L	0.74526675
54	DAPK2	0.74333414
55	SGK2	0.73066362
56	CDK3	0.72661370
57	MAPKAPK3	0.70143776
58	PTK2B	0.68693154
59	CAMK2A	0.68658583
60	MARK3	0.63833127
61	VRK1	0.62697479
62	NTRK2	0.59982425
63	AKT3	0.59509859
64	PKN1	0.59507374
65	PLK4	0.59266407
66	MST4	0.59106483
67	MKNK1	0.55030374
68	NLK	0.53782472
69	PHKG1	0.53154332
70	PHKG2	0.53154332
71	CAMK4	0.50418350
72	PRKACA	0.48855366
73	MAPK15	0.47987525
74	PIK3CG	0.47491741
75	MINK1	0.46835000
76	TGFBR1	0.46685288
77	OBSCN	0.46144330
78	ITK	0.46125917
79	PIK3CA	0.45640316
80	CAMK1	0.45498571
81	CSNK1A1	0.44648062
82	EIF2AK3	0.43090908
83	CHUK	0.42862299
84	PRKG1	0.42376509
85	CSNK1D	0.41888311
86	IKBKB	0.41481662
87	SGK223	0.41000831
88	SGK494	0.41000831
89	EPHA3	0.40539900
90	CDK19	0.40291612
91	TNK2	0.38899829
92	CAMKK1	0.38134004
93	PRKCQ	0.36967305
94	PRKCZ	0.34396120
95	PRKCA	0.33849282
96	UHMK1	0.33656612
97	PRKACB	0.33432445
98	TRPM7	0.33021175
99	MAP2K6	0.31962036
100	RPS6KA5	0.30864675

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.90053516
2	Nicotine addiction_Homo sapiens_hsa05033	2.78804988
3	Butanoate metabolism_Homo sapiens_hsa00650	2.33607991
4	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33208921
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.32530719
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.24637840
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.24146998
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.21186747
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.11870816
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.11420165
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.09350980
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.06064797
13	Ether lipid metabolism_Homo sapiens_hsa00565	1.98252128
14	Protein export_Homo sapiens_hsa03060	1.90668171
15	Taste transduction_Homo sapiens_hsa04742	1.87631691
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.87386032
17	Propanoate metabolism_Homo sapiens_hsa00640	1.66914481
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.64766173
19	Homologous recombination_Homo sapiens_hsa03440	1.62534219
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.61815384
21	Morphine addiction_Homo sapiens_hsa05032	1.59612577
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.57396593
23	Basal transcription factors_Homo sapiens_hsa03022	1.56236069
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.55899857
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.52548973
26	Olfactory transduction_Homo sapiens_hsa04740	1.52109482
27	Regulation of autophagy_Homo sapiens_hsa04140	1.47455344
28	Caffeine metabolism_Homo sapiens_hsa00232	1.46772257
29	Circadian entrainment_Homo sapiens_hsa04713	1.46024669
30	ABC transporters_Homo sapiens_hsa02010	1.43519214
31	Glutamatergic synapse_Homo sapiens_hsa04724	1.40349140
32	GABAergic synapse_Homo sapiens_hsa04727	1.37008872
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.35527546
34	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.34486895
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.33025873
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.32393706
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30694319
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.30328142
39	Serotonergic synapse_Homo sapiens_hsa04726	1.30323697
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11650705
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.11098533
42	Retinol metabolism_Homo sapiens_hsa00830	1.10289374
43	Insulin secretion_Homo sapiens_hsa04911	1.08945983
44	Parkinsons disease_Homo sapiens_hsa05012	1.03354521
45	Salivary secretion_Homo sapiens_hsa04970	1.02389987
46	RNA degradation_Homo sapiens_hsa03018	1.02127892
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97999791
48	Glycerolipid metabolism_Homo sapiens_hsa00561	0.96498043
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.94093769
50	Dopaminergic synapse_Homo sapiens_hsa04728	0.89103106
51	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.88817124
52	RNA polymerase_Homo sapiens_hsa03020	0.87981165
53	Histidine metabolism_Homo sapiens_hsa00340	0.87773940
54	Calcium signaling pathway_Homo sapiens_hsa04020	0.87456881
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85361464
56	Amphetamine addiction_Homo sapiens_hsa05031	0.82935186
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.82691814
58	Peroxisome_Homo sapiens_hsa04146	0.81104773
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80856869
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79696492
61	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.78139715
62	Cocaine addiction_Homo sapiens_hsa05030	0.76461970
63	Renin secretion_Homo sapiens_hsa04924	0.75529572
64	Huntingtons disease_Homo sapiens_hsa05016	0.74023698
65	Circadian rhythm_Homo sapiens_hsa04710	0.71543109
66	Asthma_Homo sapiens_hsa05310	0.70186697
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.68769814
68	Long-term depression_Homo sapiens_hsa04730	0.66138470
69	Type I diabetes mellitus_Homo sapiens_hsa04940	0.65225152
70	Alzheimers disease_Homo sapiens_hsa05010	0.64657469
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.62467627
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.62366493
73	Purine metabolism_Homo sapiens_hsa00230	0.61816696
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61567281
75	Graft-versus-host disease_Homo sapiens_hsa05332	0.57268631
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.56993600
77	Cholinergic synapse_Homo sapiens_hsa04725	0.55326625
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53870684
79	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.53519720
80	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.50959575
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49375530
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49218942
83	Metabolic pathways_Homo sapiens_hsa01100	0.46869485
84	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.46082601
85	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44800020
86	Pancreatic secretion_Homo sapiens_hsa04972	0.43055944
87	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.42146504
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.41779423
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.41495273
90	Primary immunodeficiency_Homo sapiens_hsa05340	0.40566187
91	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40318415
92	Gastric acid secretion_Homo sapiens_hsa04971	0.40198217
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36840926
94	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.36562505
95	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.35749307
96	Rheumatoid arthritis_Homo sapiens_hsa05323	0.33383996
97	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.31958001
98	Mineral absorption_Homo sapiens_hsa04978	0.31952958
99	Lysine degradation_Homo sapiens_hsa00310	0.31877446
100	Fatty acid degradation_Homo sapiens_hsa00071	0.31859518

SKINT1L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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