SKIV2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.14246680
2COPI coating of Golgi vesicle (GO:0048205)5.14246680
3alpha-linolenic acid metabolic process (GO:0036109)4.59059930
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.55756779
5L-phenylalanine catabolic process (GO:0006559)4.55756779
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.37004122
7L-phenylalanine metabolic process (GO:0006558)4.37004122
8regulation of cholesterol homeostasis (GO:2000188)4.35271785
9negative regulation of erythrocyte differentiation (GO:0045647)4.21964961
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.07958250
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.07958250
12urea metabolic process (GO:0019627)3.91917315
13urea cycle (GO:0000050)3.91917315
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.82746137
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.80306920
16lysine metabolic process (GO:0006553)3.75350733
17lysine catabolic process (GO:0006554)3.75350733
18positive regulation of histone deacetylation (GO:0031065)3.72244223
19aromatic amino acid family catabolic process (GO:0009074)3.72030339
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.71864198
21negative regulation of sterol transport (GO:0032372)3.71708960
22negative regulation of cholesterol transport (GO:0032375)3.71708960
23protein retention in ER lumen (GO:0006621)3.66118643
24complement activation, alternative pathway (GO:0006957)3.63755311
25regulation of gamma-delta T cell differentiation (GO:0045586)3.61861172
26regulation of fatty acid beta-oxidation (GO:0031998)3.61745744
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.59816243
28antigen processing and presentation of endogenous antigen (GO:0019883)3.59644861
29protein carboxylation (GO:0018214)3.55492163
30peptidyl-glutamic acid carboxylation (GO:0017187)3.55492163
31valine metabolic process (GO:0006573)3.51231875
32sulfur amino acid catabolic process (GO:0000098)3.51035690
33negative regulation of fibrinolysis (GO:0051918)3.50375203
34cysteine metabolic process (GO:0006534)3.49434336
35kynurenine metabolic process (GO:0070189)3.49279083
36positive thymic T cell selection (GO:0045059)3.46939982
37protein localization to endosome (GO:0036010)3.45294869
38nitrogen cycle metabolic process (GO:0071941)3.45153175
39positive regulation of gamma-delta T cell activation (GO:0046645)3.45149246
40glyoxylate metabolic process (GO:0046487)3.32597568
41proline biosynthetic process (GO:0006561)3.32563867
42regulation of protein activation cascade (GO:2000257)3.32449955
43phospholipid homeostasis (GO:0055091)3.31258885
44dicarboxylic acid biosynthetic process (GO:0043650)3.31214911
45positive regulation of fatty acid beta-oxidation (GO:0032000)3.25145486
46bile acid biosynthetic process (GO:0006699)3.24685790
47phospholipid efflux (GO:0033700)3.23304360
48cellular ketone body metabolic process (GO:0046950)3.19004625
49protein-lipid complex assembly (GO:0065005)3.18908815
50pinocytosis (GO:0006907)3.18754946
51high-density lipoprotein particle remodeling (GO:0034375)3.17840319
52positive regulation of Cdc42 GTPase activity (GO:0043089)3.17639826
53positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.15950455
54regulation of complement activation (GO:0030449)3.15158079
55embryonic process involved in female pregnancy (GO:0060136)3.14739995
56plasma lipoprotein particle clearance (GO:0034381)3.14187434
57plasma lipoprotein particle assembly (GO:0034377)3.12196429
58low-density lipoprotein particle clearance (GO:0034383)3.11437224
59activation of Rac GTPase activity (GO:0032863)3.11266831
60regulation of gamma-delta T cell activation (GO:0046643)3.10075215
61regulation of triglyceride catabolic process (GO:0010896)3.06616099
622-oxoglutarate metabolic process (GO:0006103)3.04213574
63regulation of fibrinolysis (GO:0051917)3.03411186
64indole-containing compound catabolic process (GO:0042436)3.03112549
65indolalkylamine catabolic process (GO:0046218)3.03112549
66tryptophan catabolic process (GO:0006569)3.03112549
67apoptotic process involved in morphogenesis (GO:0060561)3.01040440
68basement membrane organization (GO:0071711)3.00880804
69ethanol oxidation (GO:0006069)3.00161134
70reverse cholesterol transport (GO:0043691)3.00157942
71regulation of histone H3-K27 methylation (GO:0061085)2.98843741
72activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.97955488
73macroautophagy (GO:0016236)2.94397257
74positive regulation of lipid catabolic process (GO:0050996)2.94227772
75negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93881591
76negative regulation of cell killing (GO:0031342)2.93881591
77regulation of cholesterol storage (GO:0010885)2.92319555
78regulation of extracellular matrix disassembly (GO:0010715)2.91883082
79amino-acid betaine metabolic process (GO:0006577)2.88598816
80cell-substrate adherens junction assembly (GO:0007045)2.88300859
81focal adhesion assembly (GO:0048041)2.88300859
82bile acid metabolic process (GO:0008206)2.87807796
83positive regulation of nuclease activity (GO:0032075)2.86787249
84cellular modified amino acid catabolic process (GO:0042219)2.86291182
85mannose metabolic process (GO:0006013)2.83093171
86response to laminar fluid shear stress (GO:0034616)2.82036829
87positive regulation of triglyceride metabolic process (GO:0090208)2.81651052
88thymic T cell selection (GO:0045061)2.81457873
89glutamate metabolic process (GO:0006536)2.80534581
90homocysteine metabolic process (GO:0050667)2.80534204
91tricarboxylic acid metabolic process (GO:0072350)2.80450524
92aspartate family amino acid catabolic process (GO:0009068)2.79951804
93cholesterol efflux (GO:0033344)2.79442443
94adherens junction assembly (GO:0034333)2.78957841
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.77681070
96tryptophan metabolic process (GO:0006568)2.76923107
97pentose-phosphate shunt (GO:0006098)2.76740096
98acylglycerol homeostasis (GO:0055090)2.75500120
99triglyceride homeostasis (GO:0070328)2.75500120
100positive regulation of triglyceride biosynthetic process (GO:0010867)2.74946321
101regulation of mammary gland epithelial cell proliferation (GO:0033599)2.73936960
102NIK/NF-kappaB signaling (GO:0038061)2.73718553
103negative regulation of lipid transport (GO:0032369)2.73327738
104ketone body metabolic process (GO:1902224)2.72870391
105modulation by symbiont of host cellular process (GO:0044068)2.72568107
106glucose 6-phosphate metabolic process (GO:0051156)2.72071802
107acetyl-CoA metabolic process (GO:0006084)2.71395183
108response to muramyl dipeptide (GO:0032495)2.70762706
109negative thymic T cell selection (GO:0045060)2.70167601
110positive T cell selection (GO:0043368)2.68186550
111negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.67326352
112negative T cell selection (GO:0043383)2.66982029
113cell-substrate junction assembly (GO:0007044)2.64933225
114regulation of lipid catabolic process (GO:0050994)2.64917947
115regulation of sterol transport (GO:0032371)2.63170502
116regulation of cholesterol transport (GO:0032374)2.63170502
117epithelial cell differentiation involved in prostate gland development (GO:0060742)2.62062097
118negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61737743
119negative regulation of cell size (GO:0045792)2.61088635
120regulation of early endosome to late endosome transport (GO:2000641)2.61079052
121intestinal cholesterol absorption (GO:0030299)2.61040798
122protein-lipid complex remodeling (GO:0034368)2.60720689
123macromolecular complex remodeling (GO:0034367)2.60720689
124plasma lipoprotein particle remodeling (GO:0034369)2.60720689
125detection of bacterium (GO:0016045)2.59829753
126regulation of nuclease activity (GO:0032069)2.58344741
127alpha-amino acid catabolic process (GO:1901606)2.57966266
1283-UTR-mediated mRNA stabilization (GO:0070935)2.57933854
129endoplasmic reticulum unfolded protein response (GO:0030968)2.57839763
130spliceosomal tri-snRNP complex assembly (GO:0000244)2.57649239
131fatty acid homeostasis (GO:0055089)2.57326751
132positive regulation of extracellular matrix organization (GO:1903055)2.57047140
133fatty acid transmembrane transport (GO:1902001)2.56940504
134positive regulation of fatty acid biosynthetic process (GO:0045723)2.56507659
135detection of other organism (GO:0098543)2.55069246
136regulation of cholesterol biosynthetic process (GO:0045540)2.54145455
137proline metabolic process (GO:0006560)2.53315243
138regulation of fatty acid oxidation (GO:0046320)2.53262055
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.52115920
140drug catabolic process (GO:0042737)2.51983070
141complement activation, classical pathway (GO:0006958)2.51934938
142cholesterol homeostasis (GO:0042632)2.50580921
143protein-lipid complex subunit organization (GO:0071825)2.50028849
144positive regulation of fatty acid oxidation (GO:0046321)2.49913855
145regulation of ARF GTPase activity (GO:0032312)2.49822488
146modulation by virus of host process (GO:0019054)2.48966275
147maternal placenta development (GO:0001893)2.46693772
148regulation of glucose import in response to insulin stimulus (GO:2001273)2.44455851
149semaphorin-plexin signaling pathway (GO:0071526)2.43879709
150cytoskeletal anchoring at plasma membrane (GO:0007016)2.43808534
151stress fiber assembly (GO:0043149)2.43775453
152vesicle coating (GO:0006901)2.43546231
153positive regulation by symbiont of host defense response (GO:0052509)2.43271182
154modulation by symbiont of host defense response (GO:0052031)2.43271182
155modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.43271182
156modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.43271182
157positive regulation by organism of defense response of other organism involved in symbiotic interact2.43271182
158modulation by symbiont of host immune response (GO:0052553)2.43271182
159regulation of extracellular matrix organization (GO:1903053)2.43084143
160ER-nucleus signaling pathway (GO:0006984)2.42260761
161glucose catabolic process (GO:0006007)2.42218249
162positive regulation of blood vessel endothelial cell migration (GO:0043536)2.41567268
163regulation of defense response to virus by virus (GO:0050690)2.39462675
164negative regulation of viral release from host cell (GO:1902187)2.39379039
165regulation of NFAT protein import into nucleus (GO:0051532)2.39376095
166barbed-end actin filament capping (GO:0051016)2.37121118
167regulation of translational fidelity (GO:0006450)2.35865115
168skin morphogenesis (GO:0043589)2.35715053
169cellular response to epidermal growth factor stimulus (GO:0071364)2.34899193
170cellular response to unfolded protein (GO:0034620)2.34150824
171positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.33414524
172NADPH regeneration (GO:0006740)2.33290642
173response to peptidoglycan (GO:0032494)2.32595896
174negative regulation of fatty acid transport (GO:2000192)2.30414325
175germinal center formation (GO:0002467)2.29817248
176cellular response to virus (GO:0098586)2.29151166
177detection of external biotic stimulus (GO:0098581)2.28973095
178retrograde transport, endosome to Golgi (GO:0042147)2.28302740
179regulation of superoxide anion generation (GO:0032928)2.26215005
180regulation of necroptotic process (GO:0060544)2.26089141
181regulation of chromatin binding (GO:0035561)2.25561494
182snRNA metabolic process (GO:0016073)2.24398337
183activation of MAPKKK activity (GO:0000185)2.23273646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.60688705
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.07202839
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.82735726
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.34268362
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.23088745
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00438817
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.81098250
8MYC_22102868_ChIP-Seq_BL_Human2.63550108
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.42646964
10VDR_21846776_ChIP-Seq_THP-1_Human2.22634726
11LXR_22292898_ChIP-Seq_THP-1_Human2.20553076
12* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17439963
13KDM2B_26808549_Chip-Seq_DND41_Human2.17009530
14TCF7_22412390_ChIP-Seq_EML_Mouse2.16803581
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.12560856
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.12484723
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12418165
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02524914
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94123034
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91775628
21CLOCK_20551151_ChIP-Seq_293T_Human1.87607428
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79444924
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.77857153
24MAF_26560356_Chip-Seq_TH1_Human1.77107323
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.75897400
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.74183574
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.72196368
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68998445
29UTX_26944678_Chip-Seq_JUKART_Human1.68378882
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.66273081
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63786898
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62988131
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62565547
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58991213
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57476392
36RACK7_27058665_Chip-Seq_MCF-7_Human1.49337050
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.48863855
38RUNX_20019798_ChIP-Seq_JUKART_Human1.48730137
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.47475316
40CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.47469811
41E2F7_22180533_ChIP-Seq_HELA_Human1.46376235
42ZNF263_19887448_ChIP-Seq_K562_Human1.45947588
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.43740966
44GATA1_19941826_ChIP-Seq_K562_Human1.43256593
45GATA1_22025678_ChIP-Seq_K562_Human1.42835845
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40457564
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40020475
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.39796544
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36616956
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.36522749
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35531989
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35517726
53VDR_24763502_ChIP-Seq_THP-1_Human1.34759387
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.34351654
55KDM2B_26808549_Chip-Seq_K562_Human1.33030261
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.32634799
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32596439
58* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31221066
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30857689
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30791578
61EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30457384
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.30320795
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30293157
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29485276
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29019834
66SCL_19346495_ChIP-Seq_HPC-7_Human1.28899582
67MYB_26560356_Chip-Seq_TH1_Human1.28667189
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28433673
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27591001
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26138873
71P68_20966046_ChIP-Seq_HELA_Human1.25154581
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.24806840
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24715355
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24191846
75FOXM1_23109430_ChIP-Seq_U2OS_Human1.23762685
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21720380
77ATF3_27146783_Chip-Seq_COLON_Human1.21268720
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20466095
79MAF_26560356_Chip-Seq_TH2_Human1.20042394
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19778849
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19652345
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19558524
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19544057
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19241317
85SPI1_23127762_ChIP-Seq_K562_Human1.19210880
86CREB1_26743006_Chip-Seq_LNCaP_Human1.18725931
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17231526
88MYB_26560356_Chip-Seq_TH2_Human1.16819751
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16486058
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16393453
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15960774
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15510137
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15055169
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15038101
95MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14823931
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14620517
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.14481972
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14388754
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12828696
100SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12748077
101GATA2_19941826_ChIP-Seq_K562_Human1.11381788
102IRF8_27001747_Chip-Seq_BMDM_Mouse1.10776290
103BCOR_27268052_Chip-Seq_Bcells_Human1.10181768
104SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09648135
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09461651
106NCOR1_26117541_ChIP-Seq_K562_Human1.07887116
107RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07784039
108MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07398530
109* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07203202
110CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05583092
111TP53_22127205_ChIP-Seq_IMR90_Human1.04804173
112RUNX1_22412390_ChIP-Seq_EML_Mouse1.03935031
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03532649
114RUNX1_27514584_Chip-Seq_MCF-7_Human1.02770912
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02290192
116SMC4_20622854_ChIP-Seq_HELA_Human1.02215011
117MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02016624
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01853816
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01042367
120TBX20_22080862_ChIP-Seq_HEART_Mouse1.00760541
121TBX20_22328084_ChIP-Seq_HEART_Mouse1.00760541
122TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00705473
123SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00578437
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00228568
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00021957
126BCL6_27268052_Chip-Seq_Bcells_Human0.99736007
127ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99444465
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99032574
129RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97521732
130SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97413690
131ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96751488
132CIITA_25753668_ChIP-Seq_RAJI_Human0.96654379
133SA1_27219007_Chip-Seq_ERYTHROID_Human0.96203259
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95737152
135CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95597755
136GATA3_27048872_Chip-Seq_THYMUS_Human0.95186763
137CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95101319
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94617621
139STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94481950

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.95698225
2MP0002139_abnormal_hepatobiliary_system4.81482582
3MP0005365_abnormal_bile_salt3.76684268
4MP0005085_abnormal_gallbladder_physiolo3.25211781
5MP0003705_abnormal_hypodermis_morpholog3.07598881
6MP0009840_abnormal_foam_cell2.89809541
7MP0008260_abnormal_autophagy2.87278718
8MP0003252_abnormal_bile_duct2.86102115
9MP0003300_gastrointestinal_ulcer2.84496137
10MP0010329_abnormal_lipoprotein_level2.63653975
11MP0008875_abnormal_xenobiotic_pharmacok2.58944434
12MP0003191_abnormal_cellular_cholesterol2.57728517
13MP0005083_abnormal_biliary_tract2.33892271
14MP0008961_abnormal_basal_metabolism2.18207910
15MP0001666_abnormal_nutrient_absorption2.05385045
16MP0000609_abnormal_liver_physiology2.00166020
17MP0002877_abnormal_melanocyte_morpholog1.96397566
18MP0000858_altered_metastatic_potential1.92715566
19MP0005670_abnormal_white_adipose1.77653198
20MP0000604_amyloidosis1.74564807
21MP0000685_abnormal_immune_system1.73267581
22MP0004858_abnormal_nervous_system1.70937310
23MP0003303_peritoneal_inflammation1.70660802
24MP0010234_abnormal_vibrissa_follicle1.67355409
25MP0002118_abnormal_lipid_homeostasis1.65557596
26MP0004947_skin_inflammation1.65458400
27MP0004130_abnormal_muscle_cell1.62138517
28MP0009333_abnormal_splenocyte_physiolog1.53958539
29MP0003172_abnormal_lysosome_physiology1.52322763
30MP0002166_altered_tumor_susceptibility1.50923132
31MP0002138_abnormal_hepatobiliary_system1.49742852
32MP0003806_abnormal_nucleotide_metabolis1.48961311
33MP0005332_abnormal_amino_acid1.47818780
34MP0003436_decreased_susceptibility_to1.46573996
35MP0005058_abnormal_lysosome_morphology1.44887356
36MP0002396_abnormal_hematopoietic_system1.44841203
37MP0003329_amyloid_beta_deposits1.43102670
38MP0001873_stomach_inflammation1.41635244
39MP0004185_abnormal_adipocyte_glucose1.39622913
40MP0005076_abnormal_cell_differentiation1.38335830
41MP0005666_abnormal_adipose_tissue1.36180512
42MP0004233_abnormal_muscle_weight1.35583685
43MP0005464_abnormal_platelet_physiology1.33848618
44MP0003656_abnormal_erythrocyte_physiolo1.30298203
45MP0000569_abnormal_digit_pigmentation1.27409117
46MP0005584_abnormal_enzyme/coenzyme_acti1.24355391
47MP0001800_abnormal_humoral_immune1.24221917
48MP0005319_abnormal_enzyme/_coenzyme1.22799180
49MP0001790_abnormal_immune_system1.22780978
50MP0005387_immune_system_phenotype1.22780978
51MP0005375_adipose_tissue_phenotype1.22157805
52MP0001533_abnormal_skeleton_physiology1.21244055
53MP0004272_abnormal_basement_membrane1.21207288
54MP0009643_abnormal_urine_homeostasis1.20969289
55MP0005409_darkened_coat_color1.20914201
56MP0003763_abnormal_thymus_physiology1.20549920
57MP0009278_abnormal_bone_marrow1.20146901
58MP0004264_abnormal_extraembryonic_tissu1.19361167
59MP0001915_intracranial_hemorrhage1.18619616
60MP0001348_abnormal_lacrimal_gland1.16837447
61MP0010352_gastrointestinal_tract_polyps1.16760459
62MP0001853_heart_inflammation1.16299781
63MP0002254_reproductive_system_inflammat1.16152515
64MP0002089_abnormal_postnatal_growth/wei1.16128536
65MP0000678_abnormal_parathyroid_gland1.15863574
66MP0002060_abnormal_skin_morphology1.13808754
67MP0004510_myositis1.12806525
68MP0003045_fibrosis1.10361854
69MP0003183_abnormal_peptide_metabolism1.10281123
70MP0001661_extended_life_span1.10206744
71MP0000598_abnormal_liver_morphology1.10189377
72MP0005621_abnormal_cell_physiology1.08414764
73MP0002998_abnormal_bone_remodeling1.07027932
74MP0005257_abnormal_intraocular_pressure1.06935724
75MP0003279_aneurysm1.05081212
76MP0004808_abnormal_hematopoietic_stem1.05004070
77MP0005501_abnormal_skin_physiology1.03487278
78MP0000003_abnormal_adipose_tissue1.01261609
79MP0002971_abnormal_brown_adipose0.99800796
80MP0003566_abnormal_cell_adhesion0.97801744
81MP0001730_embryonic_growth_arrest0.97649690
82MP0001958_emphysema0.97376102
83MP0002796_impaired_skin_barrier0.97062781
84MP0002909_abnormal_adrenal_gland0.96068307
85MP0008469_abnormal_protein_level0.95255039
86MP0003075_altered_response_to0.95033508
87MP0002933_joint_inflammation0.94397367
88MP0000703_abnormal_thymus_morphology0.93560582
89MP0003866_abnormal_defecation0.93310327
90MP0002405_respiratory_system_inflammati0.92954329
91MP0001835_abnormal_antigen_presentation0.91833387
92MP0002429_abnormal_blood_cell0.91693375
93MP0003868_abnormal_feces_composition0.90198385
94MP0010155_abnormal_intestine_physiology0.89738843
95MP0005023_abnormal_wound_healing0.87749271
96MP0003111_abnormal_nucleus_morphology0.87391921
97MP0003283_abnormal_digestive_organ0.87230444
98MP0000733_abnormal_muscle_development0.87068989
99MP0009780_abnormal_chondrocyte_physiolo0.87068022
100MP0000751_myopathy0.86517227
101MP0002723_abnormal_immune_serum0.86133000
102MP0005334_abnormal_fat_pad0.85509265
103MP0004381_abnormal_hair_follicle0.85454319
104MP0009763_increased_sensitivity_to0.84906525
105MP0000490_abnormal_crypts_of0.84847029
106MP0000747_muscle_weakness0.84325538
107MP0002452_abnormal_antigen_presenting0.83200449
108MP0001845_abnormal_inflammatory_respons0.82759246
109MP0000767_abnormal_smooth_muscle0.80930467
110MP0002398_abnormal_bone_marrow0.80887324
111MP0001851_eye_inflammation0.79907927
112MP0003690_abnormal_glial_cell0.79833770
113MP0009931_abnormal_skin_appearance0.79640966
114MP0003453_abnormal_keratinocyte_physiol0.79298819
115MP0001216_abnormal_epidermal_layer0.78761970
116MP0004019_abnormal_vitamin_homeostasis0.78718077
117MP0001849_ear_inflammation0.78594158
118MP0006082_CNS_inflammation0.78496188
119MP0002078_abnormal_glucose_homeostasis0.78466351
120MP0005025_abnormal_response_to0.78272011
121MP0002136_abnormal_kidney_physiology0.78269354
122MP0002928_abnormal_bile_duct0.78049257
123MP0002132_abnormal_respiratory_system0.77751483
124MP0002420_abnormal_adaptive_immunity0.77703752
125MP0009785_altered_susceptibility_to0.77536282
126MP0003195_calcinosis0.77512726
127MP0002970_abnormal_white_adipose0.75880474
128MP0001819_abnormal_immune_cell0.75865173
129MP0008874_decreased_physiological_sensi0.75475078
130MP0002006_tumorigenesis0.75130443
131MP0005000_abnormal_immune_tolerance0.74249551
132MP0000689_abnormal_spleen_morphology0.74231801
133MP0002419_abnormal_innate_immunity0.74048385
134MP0000716_abnormal_immune_system0.72676500
135MP0003091_abnormal_cell_migration0.71638943
136MP0005451_abnormal_body_composition0.71385736
137MP0002722_abnormal_immune_system0.69881384
138MP0009642_abnormal_blood_homeostasis0.69743883
139MP0008438_abnormal_cutaneous_collagen0.69603193
140MP0001756_abnormal_urination0.69156727
141MP0005397_hematopoietic_system_phenotyp0.68362761
142MP0001545_abnormal_hematopoietic_system0.68362761
143MP0001765_abnormal_ion_homeostasis0.68254795

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.89430810
2Xanthomatosis (HP:0000991)3.84339273
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.58689231
4Complement deficiency (HP:0004431)3.54640677
5Intrahepatic cholestasis (HP:0001406)3.46818139
6Abnormality of monocarboxylic acid metabolism (HP:0010996)3.37187732
7Protrusio acetabuli (HP:0003179)3.11009920
8Vertebral compression fractures (HP:0002953)3.07661098
9Cerebral aneurysm (HP:0004944)2.99582289
10Premature rupture of membranes (HP:0001788)2.96092362
11Broad face (HP:0000283)2.91735533
12Hyperlipoproteinemia (HP:0010980)2.87089053
13Nasal polyposis (HP:0100582)2.87028566
14Myocardial infarction (HP:0001658)2.86631332
15Abnormality of the common coagulation pathway (HP:0010990)2.85536227
16Cervical subluxation (HP:0003308)2.74226748
17Mitral stenosis (HP:0001718)2.69644123
18Hypobetalipoproteinemia (HP:0003563)2.69368964
19Ketosis (HP:0001946)2.68283346
20Abnormality of complement system (HP:0005339)2.65610907
21Eczematoid dermatitis (HP:0000976)2.64049756
22Epidermoid cyst (HP:0200040)2.60631366
23Abnormality of the nasal mucosa (HP:0000433)2.58565791
24Hypercholesterolemia (HP:0003124)2.56986222
25Distal lower limb amyotrophy (HP:0008944)2.55733035
26Increased connective tissue (HP:0009025)2.54173617
27Flat acetabular roof (HP:0003180)2.49408377
28Cellulitis (HP:0100658)2.47211781
29Hyperacusis (HP:0010780)2.43645106
30Prolonged partial thromboplastin time (HP:0003645)2.43471962
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.43017321
32Biconcave vertebral bodies (HP:0004586)2.42489157
33Hypoalphalipoproteinemia (HP:0003233)2.40413890
34Distal upper limb amyotrophy (HP:0007149)2.33255452
35Upper limb amyotrophy (HP:0009129)2.33255452
36Achilles tendon contracture (HP:0001771)2.33049906
37Thin bony cortex (HP:0002753)2.32835416
38J-shaped sella turcica (HP:0002680)2.32203569
39Hypolipoproteinemia (HP:0010981)2.31585297
40Joint hemorrhage (HP:0005261)2.31237806
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.30523041
42Macroorchidism (HP:0000053)2.30001022
43Hyperammonemia (HP:0001987)2.28348664
44Hemorrhage of the eye (HP:0011885)2.27882088
45Hand muscle atrophy (HP:0009130)2.26067007
46Abnormality of the lower motor neuron (HP:0002366)2.24905309
47Polycythemia (HP:0001901)2.24171941
48Mucopolysacchariduria (HP:0008155)2.20445343
49Urinary glycosaminoglycan excretion (HP:0003541)2.20445343
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13752851
51Spastic diplegia (HP:0001264)2.13193582
52Skin nodule (HP:0200036)2.12668157
53Aneurysm (HP:0002617)2.11254215
54Long toe (HP:0010511)2.09904382
55Aortic aneurysm (HP:0004942)2.09263577
56Abnormality of polysaccharide metabolism (HP:0011012)2.08846280
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08846280
58Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08846280
59Reticulocytosis (HP:0001923)2.08756833
60Global brain atrophy (HP:0002283)2.08351358
61Dilatation of the ascending aorta (HP:0005111)2.06596750
62Abnormality of macrophages (HP:0004311)2.06309169
63Interstitial pulmonary disease (HP:0006530)2.04996105
64Increased IgE level (HP:0003212)2.02803771
65Abnormality of the Achilles tendon (HP:0005109)2.02477084
66Centrally nucleated skeletal muscle fibers (HP:0003687)2.01523134
67Acanthocytosis (HP:0001927)2.00908860
68Distal lower limb muscle weakness (HP:0009053)2.00819575
69Ketoacidosis (HP:0001993)2.00737780
70Papilloma (HP:0012740)1.98368772
71Verrucae (HP:0200043)1.98368772
72Ulnar bowing (HP:0003031)1.97586465
73Long palpebral fissure (HP:0000637)1.97157390
74Gingival bleeding (HP:0000225)1.97028039
75Mitral valve prolapse (HP:0001634)1.96495867
76Abnormality of the intrinsic pathway (HP:0010989)1.96010767
77Obstructive sleep apnea (HP:0002870)1.95715814
78Heterotopia (HP:0002282)1.93100457
79Turricephaly (HP:0000262)1.92357840
80Short nail (HP:0001799)1.91805573
81Hypoglycemic coma (HP:0001325)1.91145986
82Systemic lupus erythematosus (HP:0002725)1.90532532
83Striae distensae (HP:0001065)1.90239406
84Back pain (HP:0003418)1.90055946
85Pseudobulbar signs (HP:0002200)1.90041667
86Cerebral inclusion bodies (HP:0100314)1.88553471
87Cholelithiasis (HP:0001081)1.87559914
88Disproportionate tall stature (HP:0001519)1.87367940
89Broad metatarsal (HP:0001783)1.86932534
90Cholecystitis (HP:0001082)1.85891362
91Abnormal gallbladder physiology (HP:0012438)1.85891362
92Gastrointestinal infarctions (HP:0005244)1.85154425
93Abnormality of the thoracic spine (HP:0100711)1.84388163
94Increased CSF protein (HP:0002922)1.84256718
95Insomnia (HP:0100785)1.83918218
96Metaphyseal cupping (HP:0003021)1.83685427
97Esophageal varix (HP:0002040)1.83056315
98Hypertensive crisis (HP:0100735)1.83041192
99Blue sclerae (HP:0000592)1.82874728
100Dysmetric saccades (HP:0000641)1.82624942
101Lymphangioma (HP:0100764)1.81533395
102Asymmetry of the thorax (HP:0001555)1.81475681
103Neonatal onset (HP:0003623)1.81111899
104Ankyloglossia (HP:0010296)1.80643694
105Chronic otitis media (HP:0000389)1.80270767
106Segmental peripheral demyelination/remyelination (HP:0003481)1.78860763
107Increased mean platelet volume (HP:0011877)1.78594620
108Abnormal gallbladder morphology (HP:0012437)1.78130345
109Recurrent viral infections (HP:0004429)1.78073900
110Hyperbilirubinemia (HP:0002904)1.78015126
111Abnormal platelet volume (HP:0011876)1.76191284
112Autoimmune thrombocytopenia (HP:0001973)1.76034105
113Hepatocellular carcinoma (HP:0001402)1.75373492
114Difficulty climbing stairs (HP:0003551)1.75266365
115Polygenic inheritance (HP:0010982)1.75251656
116Peritonitis (HP:0002586)1.75166873
117Sensorimotor neuropathy (HP:0007141)1.75155674
118Late onset (HP:0003584)1.74895555
119Fat malabsorption (HP:0002630)1.74765535
120Hypertriglyceridemia (HP:0002155)1.74744891
121Spinal cord lesions (HP:0100561)1.74528975
122Syringomyelia (HP:0003396)1.74528975
123Abnormality of the fingertips (HP:0001211)1.74050811
124Abnormality of oral frenula (HP:0000190)1.74008800
125T lymphocytopenia (HP:0005403)1.73927689
126Recurrent abscess formation (HP:0002722)1.73660564
127Menorrhagia (HP:0000132)1.73465157
128Recurrent bronchitis (HP:0002837)1.72929819
129Gingivitis (HP:0000230)1.72794610
130Amyloidosis (HP:0011034)1.72694822
131Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72434255
132Renovascular hypertension (HP:0100817)1.72045834
133Poikilocytosis (HP:0004447)1.72013076
134Fragile skin (HP:0001030)1.71843204
135Abnormality of purine metabolism (HP:0004352)1.71225850
136Mitral regurgitation (HP:0001653)1.70092812
137Stroke (HP:0001297)1.70009276
138Increased variability in muscle fiber diameter (HP:0003557)1.69538145
139Emphysema (HP:0002097)1.68541746
140Pustule (HP:0200039)1.68192261
141Entropion (HP:0000621)1.68102722
142Recurrent gram-negative bacterial infections (HP:0005420)1.67937945
143Loss of speech (HP:0002371)1.67877780
144Hyporeflexia of lower limbs (HP:0002600)1.67699297
145Ectopia lentis (HP:0001083)1.67218493
146Neoplasm of the heart (HP:0100544)1.66735185
147Increased serum ferritin (HP:0003281)1.66724543
148Impaired platelet aggregation (HP:0003540)1.66658518
149Abnormal platelet function (HP:0011869)1.66658518
150Fatigue (HP:0012378)1.66483071
151Purpura (HP:0000979)1.66100954
152Recurrent bacterial skin infections (HP:0005406)1.66097834
153Dysostosis multiplex (HP:0000943)1.66029884
154Frequent falls (HP:0002359)1.65932777
155Axonal loss (HP:0003447)1.65138590
156Neuronal loss in central nervous system (HP:0002529)1.64597708
157Elevated alkaline phosphatase (HP:0003155)1.64496345
158Wormian bones (HP:0002645)1.63659257
159Stridor (HP:0010307)1.63534935
160Abnormality of the distal phalanges of the toes (HP:0010182)1.63381628
161Dislocated radial head (HP:0003083)1.62033858
162Atrophic scars (HP:0001075)1.61902824
163Arterial tortuosity (HP:0005116)1.61726894
164Lower limb amyotrophy (HP:0007210)1.60185204
165Osteolytic defects of the phalanges of the hand (HP:0009771)1.59962716
166Osteolytic defects of the hand bones (HP:0009699)1.59962716
167Ragged-red muscle fibers (HP:0003200)1.59770702
168Nuclear cataract (HP:0100018)1.59075274
169Mildly elevated creatine phosphokinase (HP:0008180)1.58658039
170Obstructive lung disease (HP:0006536)1.58199462
171Chronic obstructive pulmonary disease (HP:0006510)1.58199462
172Easy fatigability (HP:0003388)1.57817490

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.25077108
2ERN13.40661877
3MAP3K103.34422867
4SMG13.18308153
5PKN23.13015387
6EEF2K3.05122892
7PRPF4B3.00117218
8SIK12.81720000
9FGFR42.76835063
10MAP4K12.71617767
11IRAK32.25623002
12PTK62.01435715
13RIPK11.87773110
14TYK21.85941730
15GRK61.73478993
16ICK1.72699753
17EPHB11.71407101
18SIK21.65162817
19RIPK41.64170641
20TTN1.63262098
21MAP3K131.62695909
22JAK11.62309525
23MAP3K71.55564517
24CAMK1G1.51109399
25NME21.51038019
26EPHA21.49170572
27STK101.42187842
28MAP3K31.32539489
29CAMK1D1.31801037
30TAOK11.31551864
31TBK11.27517736
32BCKDK1.25262353
33LRRK21.24952802
34JAK31.23784069
35PDGFRA1.21735270
36SIK31.21088719
37TAOK31.20308580
38ZAP701.14449056
39CDK121.12056750
40KSR21.12038316
41JAK21.10806909
42IRAK41.10641106
43MAP3K111.10508814
44PRKCH1.09527101
45ITK1.07756403
46FGFR31.05273220
47RET1.04200863
48TGFBR21.03308304
49TAOK21.00970143
50MAP2K30.98503904
51FGFR20.96269580
52MTOR0.96140323
53TYRO30.95400269
54CDC42BPA0.93154538
55IKBKE0.88256480
56CSK0.87705546
57HCK0.85864333
58DYRK1B0.85532382
59MAP3K60.84420058
60PIM20.83823331
61BLK0.82154880
62CAMKK10.81864628
63MAPK110.80693800
64PDK10.79106382
65CSF1R0.78449773
66PRKD30.77430545
67ALK0.77364026
68MAP3K80.75656253
69PTK20.74761930
70ARAF0.74184007
71BMX0.74152790
72SCYL20.71866940
73FLT30.70663711
74MARK20.70143886
75PDGFRB0.70053526
76EPHA30.68854488
77PDPK10.64773782
78PAK60.62872382
79PAK20.62390727
80CDK60.61243672
81PDK40.60725739
82PDK30.60725739
83MAP3K90.60040404
84MET0.59503591
85MAP3K10.59115915
86IRAK20.58911248
87BTK0.58795915
88SYK0.57914696
89DAPK20.56035581
90SGK30.54647550
91PRKD10.54645237
92DDR20.54313188
93LCK0.53918958
94CDK70.53601709
95CDK40.52687274
96HIPK20.52483754
97TNK20.51442321
98MOS0.51342249
99KIT0.51338466
100MAP3K140.50731751
101NTRK10.50537111
102MAPK150.50041847
103TESK20.49237530
104PTK2B0.49170426
105BRAF0.49023008
106DMPK0.48356729
107RAF10.47603905
108MAPK120.47512443
109FES0.47358330
110RPS6KA20.46882656
111RPS6KC10.46515568
112RPS6KL10.46515568
113PRKCQ0.46035398
114MAP2K20.45407800
115FGR0.45173335
116PRKAA20.43772503
117NEK20.43252097
118STK110.42484043
119MAPKAPK20.40996832
120PAK40.40579107
121FYN0.39854711
122PRKD20.39683126
123EGFR0.39514460
124TESK10.39057125
125RPS6KB20.38942937
126MST1R0.38770290
127CHUK0.38449687
128PIK3CG0.38326786
129LMTK20.37402412
130PRKAA10.36225187
131MAP3K20.36160508
132KDR0.36078912
133MAP2K60.32807946
134MAPK70.31880089
135MARK30.29306068
136NEK90.28590092

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.70237724
2Other glycan degradation_Homo sapiens_hsa005113.54832105
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.99196045
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.98135555
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.51794913
6Arginine biosynthesis_Homo sapiens_hsa002202.44289312
7Fatty acid degradation_Homo sapiens_hsa000712.00262557
8Tryptophan metabolism_Homo sapiens_hsa003801.93927185
9Complement and coagulation cascades_Homo sapiens_hsa046101.88661891
10PPAR signaling pathway_Homo sapiens_hsa033201.87205391
11Caffeine metabolism_Homo sapiens_hsa002321.81148223
12Staphylococcus aureus infection_Homo sapiens_hsa051501.75522832
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73032791
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72069794
15Bile secretion_Homo sapiens_hsa049761.70971614
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69514492
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60651116
18Lysine degradation_Homo sapiens_hsa003101.57316849
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56872077
20Fructose and mannose metabolism_Homo sapiens_hsa000511.56841952
21Bladder cancer_Homo sapiens_hsa052191.49087296
22ABC transporters_Homo sapiens_hsa020101.46733587
23Selenocompound metabolism_Homo sapiens_hsa004501.45278118
24Fatty acid metabolism_Homo sapiens_hsa012121.44673850
25Notch signaling pathway_Homo sapiens_hsa043301.44248154
26Butanoate metabolism_Homo sapiens_hsa006501.43679245
27Propanoate metabolism_Homo sapiens_hsa006401.37105692
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31956102
29Thyroid cancer_Homo sapiens_hsa052161.30950540
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.28897911
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26793246
32Fat digestion and absorption_Homo sapiens_hsa049751.26496924
33Pyruvate metabolism_Homo sapiens_hsa006201.26129502
34Insulin resistance_Homo sapiens_hsa049311.19725603
35Galactose metabolism_Homo sapiens_hsa000521.16727487
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15985764
37B cell receptor signaling pathway_Homo sapiens_hsa046621.15630856
38Adipocytokine signaling pathway_Homo sapiens_hsa049201.14677763
39Influenza A_Homo sapiens_hsa051641.11821913
40Endometrial cancer_Homo sapiens_hsa052131.11329463
41Hepatitis B_Homo sapiens_hsa051611.11113721
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10909685
43Small cell lung cancer_Homo sapiens_hsa052221.09739399
44Apoptosis_Homo sapiens_hsa042101.07747500
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.06264591
46Viral carcinogenesis_Homo sapiens_hsa052031.04256977
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04154551
48Glycerolipid metabolism_Homo sapiens_hsa005611.02272292
49Lysosome_Homo sapiens_hsa041421.01869807
50Primary immunodeficiency_Homo sapiens_hsa053400.99432027
51Peroxisome_Homo sapiens_hsa041460.99040397
52TNF signaling pathway_Homo sapiens_hsa046680.96508647
53Histidine metabolism_Homo sapiens_hsa003400.95789398
54Biosynthesis of amino acids_Homo sapiens_hsa012300.94108272
55Shigellosis_Homo sapiens_hsa051310.93500344
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92270317
57Renal cell carcinoma_Homo sapiens_hsa052110.92001262
58Carbon metabolism_Homo sapiens_hsa012000.91911720
59Measles_Homo sapiens_hsa051620.91754413
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89199109
61beta-Alanine metabolism_Homo sapiens_hsa004100.88263245
62Focal adhesion_Homo sapiens_hsa045100.87843039
63Chronic myeloid leukemia_Homo sapiens_hsa052200.87307392
64Herpes simplex infection_Homo sapiens_hsa051680.86974108
65Type II diabetes mellitus_Homo sapiens_hsa049300.86148748
66T cell receptor signaling pathway_Homo sapiens_hsa046600.85322786
67Viral myocarditis_Homo sapiens_hsa054160.84035358
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83963866
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83784003
70Fatty acid biosynthesis_Homo sapiens_hsa000610.83783079
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83687110
72Amoebiasis_Homo sapiens_hsa051460.83603363
73Tuberculosis_Homo sapiens_hsa051520.82334173
74ErbB signaling pathway_Homo sapiens_hsa040120.82184493
75Starch and sucrose metabolism_Homo sapiens_hsa005000.81987374
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81198822
77HIF-1 signaling pathway_Homo sapiens_hsa040660.80777564
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79184037
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79033412
80Endocytosis_Homo sapiens_hsa041440.78564486
81Chemical carcinogenesis_Homo sapiens_hsa052040.78376436
82HTLV-I infection_Homo sapiens_hsa051660.78239497
83Choline metabolism in cancer_Homo sapiens_hsa052310.77087817
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.76642660
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75565294
86Osteoclast differentiation_Homo sapiens_hsa043800.75477785
87mTOR signaling pathway_Homo sapiens_hsa041500.73967496
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.73888287
89GnRH signaling pathway_Homo sapiens_hsa049120.73612197
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.71810199
91Glucagon signaling pathway_Homo sapiens_hsa049220.70975016
92Salmonella infection_Homo sapiens_hsa051320.70549728
93Phenylalanine metabolism_Homo sapiens_hsa003600.70447720
94AMPK signaling pathway_Homo sapiens_hsa041520.70286201
95Inositol phosphate metabolism_Homo sapiens_hsa005620.69138684
96Acute myeloid leukemia_Homo sapiens_hsa052210.68596001
97Prostate cancer_Homo sapiens_hsa052150.68291433
98Insulin signaling pathway_Homo sapiens_hsa049100.66332040
99Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66293604
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66290026
101Non-small cell lung cancer_Homo sapiens_hsa052230.66234399
102N-Glycan biosynthesis_Homo sapiens_hsa005100.65519239
103Pertussis_Homo sapiens_hsa051330.65375783
104Dorso-ventral axis formation_Homo sapiens_hsa043200.65231510
105MicroRNAs in cancer_Homo sapiens_hsa052060.64479854
106Epstein-Barr virus infection_Homo sapiens_hsa051690.64025094
107Sulfur relay system_Homo sapiens_hsa041220.64016269
108Colorectal cancer_Homo sapiens_hsa052100.63836796
109VEGF signaling pathway_Homo sapiens_hsa043700.63167995
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.62194768
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.60006031
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59947372
113Pentose phosphate pathway_Homo sapiens_hsa000300.59481567
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.59030263
115Malaria_Homo sapiens_hsa051440.58977107
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57031814
117Vibrio cholerae infection_Homo sapiens_hsa051100.55939128
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55383762
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.54217159
120Pancreatic cancer_Homo sapiens_hsa052120.53519429
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52808252
122Toxoplasmosis_Homo sapiens_hsa051450.52621593
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52409132
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.50784326
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49543740
126Adherens junction_Homo sapiens_hsa045200.49530880
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48436776
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48111954
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45196242
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.44736096
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.44403542
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.44093355
133Sulfur metabolism_Homo sapiens_hsa009200.43979166
134Prion diseases_Homo sapiens_hsa050200.42273531
135Glioma_Homo sapiens_hsa052140.42257123
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41737008
137Platelet activation_Homo sapiens_hsa046110.41524043
138Tyrosine metabolism_Homo sapiens_hsa003500.40671830
139Leishmaniasis_Homo sapiens_hsa051400.39698429
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38932503
141Estrogen signaling pathway_Homo sapiens_hsa049150.37739086
142Hepatitis C_Homo sapiens_hsa051600.37036106
143Retinol metabolism_Homo sapiens_hsa008300.36419182
144Prolactin signaling pathway_Homo sapiens_hsa049170.36384828
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35805202
146Antigen processing and presentation_Homo sapiens_hsa046120.34567356
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34414216
148Proteoglycans in cancer_Homo sapiens_hsa052050.32489668
149Chemokine signaling pathway_Homo sapiens_hsa040620.31270045
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31037590

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