

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | nuclear pore organization (GO:0006999) | 5.75648740 |
| 2 | nuclear pore complex assembly (GO:0051292) | 5.71597815 |
| 3 | DNA unwinding involved in DNA replication (GO:0006268) | 4.97104538 |
| 4 | protein localization to kinetochore (GO:0034501) | 4.86118496 |
| 5 | mitotic nuclear envelope disassembly (GO:0007077) | 4.57280158 |
| 6 | mitotic metaphase plate congression (GO:0007080) | 4.54826166 |
| 7 | mitotic sister chromatid cohesion (GO:0007064) | 4.34049664 |
| 8 | nucleobase biosynthetic process (GO:0046112) | 4.30900415 |
| 9 | establishment of integrated proviral latency (GO:0075713) | 4.30775428 |
| 10 | pore complex assembly (GO:0046931) | 4.29952125 |
| 11 | nuclear envelope disassembly (GO:0051081) | 4.29852200 |
| 12 | membrane disassembly (GO:0030397) | 4.29852200 |
| 13 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 4.23994711 |
| 14 | DNA replication initiation (GO:0006270) | 4.21828365 |
| 15 | IMP biosynthetic process (GO:0006188) | 4.19818071 |
| 16 | DNA replication-dependent nucleosome organization (GO:0034723) | 4.15284662 |
| 17 | DNA replication-dependent nucleosome assembly (GO:0006335) | 4.15284662 |
| 18 | protein localization to chromosome, centromeric region (GO:0071459) | 4.12511181 |
| 19 | regulation of spindle organization (GO:0090224) | 4.12236824 |
| 20 | metaphase plate congression (GO:0051310) | 4.10925346 |
| 21 | mitotic chromosome condensation (GO:0007076) | 4.10839248 |
| 22 | purine nucleobase biosynthetic process (GO:0009113) | 4.10591312 |
| 23 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.06414073 |
| 24 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 4.06256066 |
| 25 | mitotic sister chromatid segregation (GO:0000070) | 4.05029968 |
| 26 | sister chromatid segregation (GO:0000819) | 4.02275912 |
| 27 | positive regulation of chromosome segregation (GO:0051984) | 3.99911053 |
| 28 | kinetochore organization (GO:0051383) | 3.95190230 |
| 29 | DNA replication checkpoint (GO:0000076) | 3.92956819 |
| 30 | DNA strand elongation (GO:0022616) | 3.91695665 |
| 31 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.91451362 |
| 32 | formation of translation preinitiation complex (GO:0001731) | 3.88202686 |
| 33 | non-recombinational repair (GO:0000726) | 3.85061634 |
| 34 | double-strand break repair via nonhomologous end joining (GO:0006303) | 3.85061634 |
| 35 | * maturation of 5.8S rRNA (GO:0000460) | 3.84776386 |
| 36 | ribosome assembly (GO:0042255) | 3.84736182 |
| 37 | DNA geometric change (GO:0032392) | 3.72677069 |
| 38 | DNA duplex unwinding (GO:0032508) | 3.72301290 |
| 39 | IMP metabolic process (GO:0046040) | 3.68721155 |
| 40 | DNA ligation (GO:0006266) | 3.66363107 |
| 41 | regulation of mitotic spindle organization (GO:0060236) | 3.66099286 |
| 42 | establishment of chromosome localization (GO:0051303) | 3.63380083 |
| 43 | regulation of translational fidelity (GO:0006450) | 3.63207255 |
| 44 | regulation of centriole replication (GO:0046599) | 3.62464567 |
| 45 | regulation of chromosome segregation (GO:0051983) | 3.61382180 |
| 46 | chromatin remodeling at centromere (GO:0031055) | 3.60761759 |
| 47 | CENP-A containing nucleosome assembly (GO:0034080) | 3.56853331 |
| 48 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.56724353 |
| 49 | spindle checkpoint (GO:0031577) | 3.55352724 |
| 50 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 3.55133653 |
| 51 | negative regulation of chromosome segregation (GO:0051985) | 3.52772977 |
| 52 | positive regulation of mitotic metaphase/anaphase transition (GO:0045842) | 3.51954361 |
| 53 | positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101) | 3.51954361 |
| 54 | positive regulation of mitotic sister chromatid separation (GO:1901970) | 3.51954361 |
| 55 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.50355465 |
| 56 | negative regulation of sister chromatid segregation (GO:0033046) | 3.50355465 |
| 57 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.50355465 |
| 58 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.50355465 |
| 59 | spindle assembly checkpoint (GO:0071173) | 3.50146433 |
| 60 | regulation of centrosome cycle (GO:0046605) | 3.49641724 |
| 61 | DNA replication-independent nucleosome organization (GO:0034724) | 3.47763753 |
| 62 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.47763753 |
| 63 | mitotic spindle assembly checkpoint (GO:0007094) | 3.47430351 |
| 64 | mitotic spindle checkpoint (GO:0071174) | 3.47141465 |
| 65 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 3.45746501 |
| 66 | ribosome biogenesis (GO:0042254) | 3.43796230 |
| 67 | pre-miRNA processing (GO:0031054) | 3.43188246 |
| 68 | histone exchange (GO:0043486) | 3.42990945 |
| 69 | DNA double-strand break processing (GO:0000729) | 3.42888474 |
| 70 | nuclear envelope organization (GO:0006998) | 3.42879848 |
| 71 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.40513676 |
| 72 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.38347921 |
| 73 | regulation of histone H3-K9 methylation (GO:0051570) | 3.37593981 |
| 74 | synapsis (GO:0007129) | 3.37333513 |
| 75 | regulation of translational termination (GO:0006449) | 3.36840631 |
| 76 | regulation of mitotic sister chromatid separation (GO:0010965) | 3.35365474 |
| 77 | regulation of mitotic sister chromatid segregation (GO:0033047) | 3.35365474 |
| 78 | regulation of sister chromatid segregation (GO:0033045) | 3.35365474 |
| 79 | negative regulation of histone methylation (GO:0031061) | 3.35321494 |
| 80 | regulation of RNA export from nucleus (GO:0046831) | 3.35299070 |
| 81 | regulation of DNA endoreduplication (GO:0032875) | 3.33909983 |
| 82 | mitotic recombination (GO:0006312) | 3.31684729 |
| 83 | heterochromatin organization (GO:0070828) | 3.31059486 |
| 84 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.28653354 |
| 85 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.28653354 |
| 86 | DNA topological change (GO:0006265) | 3.28413939 |
| 87 | kinetochore assembly (GO:0051382) | 3.27307485 |
| 88 | telomere maintenance via recombination (GO:0000722) | 3.24920756 |
| 89 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.24818614 |
| 90 | negative regulation of DNA repair (GO:0045738) | 3.24400564 |
| 91 | regulation of sister chromatid cohesion (GO:0007063) | 3.24343866 |
| 92 | protein localization to chromosome (GO:0034502) | 3.22775423 |
| 93 | DNA conformation change (GO:0071103) | 3.18196417 |
| 94 | spliceosomal snRNP assembly (GO:0000387) | 3.18061680 |
| 95 | chromatin assembly or disassembly (GO:0006333) | 3.16787524 |
| 96 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.14618840 |
| 97 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.14147313 |
| 98 | protein K6-linked ubiquitination (GO:0085020) | 3.14096510 |
| 99 | telomere maintenance via telomerase (GO:0007004) | 3.12888074 |
| 100 | RNA-dependent DNA replication (GO:0006278) | 3.12148036 |
| 101 | DNA strand renaturation (GO:0000733) | 3.11321598 |
| 102 | histone-serine phosphorylation (GO:0035404) | 3.10793716 |
| 103 | tRNA aminoacylation for protein translation (GO:0006418) | 3.10484221 |
| 104 | tRNA aminoacylation (GO:0043039) | 3.09853470 |
| 105 | amino acid activation (GO:0043038) | 3.09853470 |
| 106 | postreplication repair (GO:0006301) | 3.09538436 |
| 107 | histone H2A monoubiquitination (GO:0035518) | 3.08720427 |
| 108 | chromosome segregation (GO:0007059) | 3.08676497 |
| 109 | ATP-dependent chromatin remodeling (GO:0043044) | 3.08622567 |
| 110 | monoubiquitinated protein deubiquitination (GO:0035520) | 3.07274591 |
| 111 | negative regulation of DNA recombination (GO:0045910) | 3.07063968 |
| 112 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.04826965 |
| 113 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.04826965 |
| 114 | establishment of viral latency (GO:0019043) | 3.04627878 |
| 115 | maturation of SSU-rRNA (GO:0030490) | 3.04251042 |
| 116 | meiotic chromosome segregation (GO:0045132) | 3.01790703 |
| 117 | mitotic G2/M transition checkpoint (GO:0044818) | 3.01152897 |
| 118 | mRNA transport (GO:0051028) | 3.00876059 |
| 119 | replication fork processing (GO:0031297) | 3.00358141 |
| 120 | telomere maintenance via telomere lengthening (GO:0010833) | 2.99963536 |
| 121 | chromosome condensation (GO:0030261) | 2.99225059 |
| 122 | regulation of helicase activity (GO:0051095) | 2.98080160 |
| 123 | DNA synthesis involved in DNA repair (GO:0000731) | 2.97310391 |
| 124 | rRNA catabolic process (GO:0016075) | 2.96235830 |
| 125 | regulation of centrosome duplication (GO:0010824) | 2.95702765 |
| 126 | protein complex localization (GO:0031503) | 2.94701073 |
| 127 | lysine metabolic process (GO:0006553) | 2.94289705 |
| 128 | lysine catabolic process (GO:0006554) | 2.94289705 |
| 129 | telomere maintenance (GO:0000723) | 2.94268898 |
| 130 | chromatin assembly (GO:0031497) | 2.94223249 |
| 131 | translesion synthesis (GO:0019985) | 2.92187164 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 5.16757884 |
| 2 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 4.24121316 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.12828001 |
| 4 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.33731598 |
| 5 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 3.27796732 |
| 6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.13219591 |
| 7 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.99066365 |
| 8 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 2.91370754 |
| 9 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.83175162 |
| 10 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.77861210 |
| 11 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.76769400 |
| 12 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.54816617 |
| 13 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.45502458 |
| 14 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.44380852 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.40092654 |
| 16 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.37569491 |
| 17 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.36696745 |
| 18 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.31644750 |
| 19 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.28414357 |
| 20 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.13049192 |
| 21 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 2.09947000 |
| 22 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.05310950 |
| 23 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.04614639 |
| 24 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.04458461 |
| 25 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.04012537 |
| 26 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.02211264 |
| 27 | E2F7_22180533_ChIP-Seq_HELA_Human | 10.1508220 |
| 28 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.98743734 |
| 29 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.96525591 |
| 30 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.91842018 |
| 31 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.85919089 |
| 32 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.83251528 |
| 33 | MYC_22102868_ChIP-Seq_BL_Human | 1.80813073 |
| 34 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 1.79820011 |
| 35 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.73548539 |
| 36 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.68007989 |
| 37 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.64794229 |
| 38 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.63194486 |
| 39 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.63135486 |
| 40 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.62398078 |
| 41 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.62067211 |
| 42 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.59559491 |
| 43 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.59321097 |
| 44 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.59110064 |
| 45 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.48749358 |
| 46 | * EWS_26573619_Chip-Seq_HEK293_Human | 1.45518734 |
| 47 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.43566110 |
| 48 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.42350927 |
| 49 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.42005181 |
| 50 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.41288617 |
| 51 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.40810445 |
| 52 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.38861709 |
| 53 | FUS_26573619_Chip-Seq_HEK293_Human | 1.37785400 |
| 54 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.36954827 |
| 55 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.36787083 |
| 56 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.34883916 |
| 57 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.34151434 |
| 58 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.30670214 |
| 59 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.28726812 |
| 60 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.27060606 |
| 61 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.26686862 |
| 62 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.25144769 |
| 63 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.21870000 |
| 64 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.18069998 |
| 65 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.17466651 |
| 66 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.16651401 |
| 67 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.15943552 |
| 68 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.15343622 |
| 69 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.14448259 |
| 70 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.14214666 |
| 71 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.13662106 |
| 72 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.13309627 |
| 73 | * POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.13292642 |
| 74 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.11737795 |
| 75 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.08776822 |
| 76 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.08668798 |
| 77 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.08344760 |
| 78 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.07050102 |
| 79 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.06134941 |
| 80 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.05536841 |
| 81 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 1.04619046 |
| 82 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.02687402 |
| 83 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.02490048 |
| 84 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.01097380 |
| 85 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.00366575 |
| 86 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.99669303 |
| 87 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.99194772 |
| 88 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.97926247 |
| 89 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.96283794 |
| 90 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.96222912 |
| 91 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.95495326 |
| 92 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.94080532 |
| 93 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.92743351 |
| 94 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.92725463 |
| 95 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.92374017 |
| 96 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.91275245 |
| 97 | VDR_22108803_ChIP-Seq_LS180_Human | 0.90892752 |
| 98 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.87784136 |
| 99 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.87325362 |
| 100 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.86433322 |
| 101 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.84763034 |
| 102 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.84604584 |
| 103 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.84548782 |
| 104 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.84548782 |
| 105 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.84548782 |
| 106 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.83497522 |
| 107 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.81336969 |
| 108 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.80313387 |
| 109 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.78714988 |
| 110 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.77986960 |
| 111 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.77320044 |
| 112 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.75878663 |
| 113 | TCF3_18692474_ChIP-Seq_MESCs_Mouse | 0.75606188 |
| 114 | TAF15_26573619_Chip-Seq_HEK293_Human | 0.73970026 |
| 115 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.72897393 |
| 116 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.72184704 |
| 117 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.71202669 |
| 118 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.64969136 |
| 119 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.63931944 |
| 120 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 0.63748525 |
| 121 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.63706789 |
| 122 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.62925901 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010094_abnormal_chromosome_stability | 4.84017578 |
| 2 | MP0003693_abnormal_embryo_hatching | 4.75329793 |
| 3 | MP0003111_abnormal_nucleus_morphology | 4.49522876 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 4.22439536 |
| 5 | MP0003077_abnormal_cell_cycle | 3.96055292 |
| 6 | MP0002254_reproductive_system_inflammat | 3.82516155 |
| 7 | MP0008057_abnormal_DNA_replication | 3.69121006 |
| 8 | MP0003123_paternal_imprinting | 3.65102991 |
| 9 | MP0008877_abnormal_DNA_methylation | 3.33741340 |
| 10 | MP0008058_abnormal_DNA_repair | 3.18719415 |
| 11 | MP0001730_embryonic_growth_arrest | 2.87570139 |
| 12 | MP0008007_abnormal_cellular_replicative | 2.73070207 |
| 13 | MP0010307_abnormal_tumor_latency | 2.61822180 |
| 14 | MP0010352_gastrointestinal_tract_polyps | 2.57268459 |
| 15 | MP0009697_abnormal_copulation | 2.53116316 |
| 16 | MP0000350_abnormal_cell_proliferation | 2.45189517 |
| 17 | MP0008932_abnormal_embryonic_tissue | 2.40556896 |
| 18 | MP0003121_genomic_imprinting | 2.40552756 |
| 19 | MP0002396_abnormal_hematopoietic_system | 2.20601436 |
| 20 | MP0001346_abnormal_lacrimal_gland | 2.11108810 |
| 21 | MP0001672_abnormal_embryogenesis/_devel | 2.10163696 |
| 22 | MP0005380_embryogenesis_phenotype | 2.10163696 |
| 23 | MP0001697_abnormal_embryo_size | 2.05130757 |
| 24 | MP0003984_embryonic_growth_retardation | 1.96151508 |
| 25 | MP0002088_abnormal_embryonic_growth/wei | 1.91544256 |
| 26 | MP0002084_abnormal_developmental_patter | 1.88749820 |
| 27 | MP0003567_abnormal_fetal_cardiomyocyte | 1.88727474 |
| 28 | MP0003890_abnormal_embryonic-extraembry | 1.88630733 |
| 29 | MP0003786_premature_aging | 1.86689139 |
| 30 | MP0004197_abnormal_fetal_growth/weight/ | 1.84154648 |
| 31 | MP0002085_abnormal_embryonic_tissue | 1.80580690 |
| 32 | MP0005076_abnormal_cell_differentiation | 1.77716694 |
| 33 | MP0002080_prenatal_lethality | 1.76972860 |
| 34 | MP0002086_abnormal_extraembryonic_tissu | 1.70583891 |
| 35 | MP0004808_abnormal_hematopoietic_stem | 1.64102443 |
| 36 | MP0002009_preneoplasia | 1.58571009 |
| 37 | MP0000537_abnormal_urethra_morphology | 1.52218013 |
| 38 | MP0002210_abnormal_sex_determination | 1.48296857 |
| 39 | MP0001873_stomach_inflammation | 1.41999170 |
| 40 | MP0010234_abnormal_vibrissa_follicle | 1.36544267 |
| 41 | MP0000313_abnormal_cell_death | 1.33035795 |
| 42 | MP0001145_abnormal_male_reproductive | 1.30524318 |
| 43 | MP0001929_abnormal_gametogenesis | 1.30263654 |
| 44 | MP0009672_abnormal_birth_weight | 1.30017296 |
| 45 | MP0010030_abnormal_orbit_morphology | 1.29525458 |
| 46 | MP0006292_abnormal_olfactory_placode | 1.29271185 |
| 47 | MP0001661_extended_life_span | 1.25763968 |
| 48 | MP0003787_abnormal_imprinting | 1.24433250 |
| 49 | MP0000490_abnormal_crypts_of | 1.24043778 |
| 50 | MP0001348_abnormal_lacrimal_gland | 1.23879327 |
| 51 | MP0001293_anophthalmia | 1.23652954 |
| 52 | MP0002102_abnormal_ear_morphology | 1.22660752 |
| 53 | MP0002019_abnormal_tumor_incidence | 1.20572518 |
| 54 | MP0002653_abnormal_ependyma_morphology | 1.17581815 |
| 55 | MP0009703_decreased_birth_body | 1.17278301 |
| 56 | MP0003119_abnormal_digestive_system | 1.15877259 |
| 57 | MP0002877_abnormal_melanocyte_morpholog | 1.13845131 |
| 58 | MP0006035_abnormal_mitochondrial_morpho | 1.11966445 |
| 59 | MP0003950_abnormal_plasma_membrane | 1.11043436 |
| 60 | MP0009053_abnormal_anal_canal | 1.11035916 |
| 61 | MP0003937_abnormal_limbs/digits/tail_de | 1.10361244 |
| 62 | MP0000653_abnormal_sex_gland | 1.10186059 |
| 63 | MP0002697_abnormal_eye_size | 1.10133420 |
| 64 | MP0004233_abnormal_muscle_weight | 1.09515034 |
| 65 | MP0003705_abnormal_hypodermis_morpholog | 1.07779631 |
| 66 | MP0003718_maternal_effect | 1.06419871 |
| 67 | MP0006054_spinal_hemorrhage | 1.02599481 |
| 68 | MP0002163_abnormal_gland_morphology | 1.02522710 |
| 69 | MP0000428_abnormal_craniofacial_morphol | 1.01409597 |
| 70 | MP0004264_abnormal_extraembryonic_tissu | 0.99497678 |
| 71 | MP0000703_abnormal_thymus_morphology | 0.97954809 |
| 72 | MP0002160_abnormal_reproductive_system | 0.95020124 |
| 73 | MP0005384_cellular_phenotype | 0.93159351 |
| 74 | MP0003315_abnormal_perineum_morphology | 0.92117095 |
| 75 | MP0003122_maternal_imprinting | 0.91183891 |
| 76 | MP0004147_increased_porphyrin_level | 0.90533879 |
| 77 | MP0003221_abnormal_cardiomyocyte_apopto | 0.89584340 |
| 78 | MP0001915_intracranial_hemorrhage | 0.87857641 |
| 79 | MP0006082_CNS_inflammation | 0.87603446 |
| 80 | MP0005621_abnormal_cell_physiology | 0.86292898 |
| 81 | MP0003941_abnormal_skin_development | 0.86185294 |
| 82 | MP0003698_abnormal_male_reproductive | 0.85054489 |
| 83 | MP0002111_abnormal_tail_morphology | 0.84298443 |
| 84 | MP0005397_hematopoietic_system_phenotyp | 0.84132947 |
| 85 | MP0001545_abnormal_hematopoietic_system | 0.84132947 |
| 86 | MP0000358_abnormal_cell_content/ | 0.82295475 |
| 87 | MP0001188_hyperpigmentation | 0.81393469 |
| 88 | MP0000733_abnormal_muscle_development | 0.81226019 |
| 89 | MP0010678_abnormal_skin_adnexa | 0.79883638 |
| 90 | MP0003115_abnormal_respiratory_system | 0.78044379 |
| 91 | MP0005379_endocrine/exocrine_gland_phen | 0.76584716 |
| 92 | MP0003935_abnormal_craniofacial_develop | 0.75690194 |
| 93 | MP0002233_abnormal_nose_morphology | 0.75653433 |
| 94 | MP0000647_abnormal_sebaceous_gland | 0.74904591 |
| 95 | MP0000432_abnormal_head_morphology | 0.74046555 |
| 96 | MP0005389_reproductive_system_phenotype | 0.73410353 |
| 97 | MP0003566_abnormal_cell_adhesion | 0.73386829 |
| 98 | MP0003861_abnormal_nervous_system | 0.73021133 |
| 99 | MP0002092_abnormal_eye_morphology | 0.72812305 |
| 100 | MP0005647_abnormal_sex_gland | 0.71748017 |
| 101 | MP0003763_abnormal_thymus_physiology | 0.70957988 |
| 102 | MP0002938_white_spotting | 0.70538952 |
| 103 | MP0004215_abnormal_myocardial_fiber | 0.68970457 |
| 104 | MP0009333_abnormal_splenocyte_physiolog | 0.68342034 |
| 105 | MP0006072_abnormal_retinal_apoptosis | 0.68315132 |
| 106 | MP0004133_heterotaxia | 0.68308961 |
| 107 | MP0003385_abnormal_body_wall | 0.68221193 |
| 108 | MP0002925_abnormal_cardiovascular_devel | 0.68041282 |
| 109 | MP0002398_abnormal_bone_marrow | 0.67892028 |
| 110 | MP0001286_abnormal_eye_development | 0.67771093 |
| 111 | MP0001849_ear_inflammation | 0.67004884 |
| 112 | MP0005220_abnormal_exocrine_pancreas | 0.66432469 |
| 113 | MP0001119_abnormal_female_reproductive | 0.66377043 |
| 114 | MP0002161_abnormal_fertility/fecundity | 0.66254837 |
| 115 | MP0000383_abnormal_hair_follicle | 0.65332848 |
| 116 | MP0003699_abnormal_female_reproductive | 0.64399014 |
| 117 | MP0002722_abnormal_immune_system | 0.63822692 |
| 118 | MP0002132_abnormal_respiratory_system | 0.62451180 |
| 119 | MP0002837_dystrophic_cardiac_calcinosis | 0.62405865 |
| 120 | MP0004084_abnormal_cardiac_muscle | 0.62234610 |
| 121 | MP0002114_abnormal_axial_skeleton | 0.60726515 |
| 122 | MP0000631_abnormal_neuroendocrine_gland | 0.60095643 |
| 123 | MP0001919_abnormal_reproductive_system | 0.58627600 |
| 124 | MP0003943_abnormal_hepatobiliary_system | 0.58562932 |
| 125 | MP0000266_abnormal_heart_morphology | 0.57619246 |
| 126 | MP0005023_abnormal_wound_healing | 0.57146491 |
| 127 | MP0002269_muscular_atrophy | 0.56354948 |
| 128 | MP0005187_abnormal_penis_morphology | 0.55829174 |
| 129 | MP0000689_abnormal_spleen_morphology | 0.54928891 |
| 130 | MP0000516_abnormal_urinary_system | 0.52887013 |
| 131 | MP0005367_renal/urinary_system_phenotyp | 0.52887013 |
| 132 | MP0003936_abnormal_reproductive_system | 0.52216598 |
| 133 | MP0002075_abnormal_coat/hair_pigmentati | 0.51479324 |
| 134 | MP0003755_abnormal_palate_morphology | 0.50534705 |
| 135 | MP0008770_decreased_survivor_rate | 0.49644560 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.66182308 |
| 2 | Colon cancer (HP:0003003) | 3.85898778 |
| 3 | Ependymoma (HP:0002888) | 3.73484691 |
| 4 | Medulloblastoma (HP:0002885) | 3.64391781 |
| 5 | Abnormality of the labia minora (HP:0012880) | 3.56066633 |
| 6 | Volvulus (HP:0002580) | 3.50986039 |
| 7 | Chromsome breakage (HP:0040012) | 3.44161917 |
| 8 | Abnormality of the anterior horn cell (HP:0006802) | 3.25261089 |
| 9 | Degeneration of anterior horn cells (HP:0002398) | 3.25261089 |
| 10 | Agnosia (HP:0010524) | 3.17848955 |
| 11 | Impulsivity (HP:0100710) | 3.09523145 |
| 12 | Increased nuchal translucency (HP:0010880) | 3.09420779 |
| 13 | Proximal placement of thumb (HP:0009623) | 3.07918922 |
| 14 | Patellar aplasia (HP:0006443) | 3.06327595 |
| 15 | Selective tooth agenesis (HP:0001592) | 3.06171900 |
| 16 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.01543696 |
| 17 | Breast hypoplasia (HP:0003187) | 2.98664321 |
| 18 | Abnormality of chromosome stability (HP:0003220) | 2.98110146 |
| 19 | Deviation of the thumb (HP:0009603) | 2.98092615 |
| 20 | Astrocytoma (HP:0009592) | 2.94135470 |
| 21 | Abnormality of the astrocytes (HP:0100707) | 2.94135470 |
| 22 | Rhabdomyosarcoma (HP:0002859) | 2.89214757 |
| 23 | Carpal bone hypoplasia (HP:0001498) | 2.89117447 |
| 24 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.84261174 |
| 25 | Cortical dysplasia (HP:0002539) | 2.72538548 |
| 26 | Abnormality of methionine metabolism (HP:0010901) | 2.72108633 |
| 27 | Cerebral hypomyelination (HP:0006808) | 2.70932478 |
| 28 | Glioma (HP:0009733) | 2.65643084 |
| 29 | Brushfield spots (HP:0001088) | 2.65369576 |
| 30 | Ectopic kidney (HP:0000086) | 2.62529223 |
| 31 | Meckel diverticulum (HP:0002245) | 2.62004503 |
| 32 | Pelvic girdle muscle weakness (HP:0003749) | 2.55888589 |
| 33 | Delayed closure of the anterior fontanelle (HP:0001476) | 2.47892401 |
| 34 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.46521565 |
| 35 | Myelodysplasia (HP:0002863) | 2.45964462 |
| 36 | Abnormality of the ileum (HP:0001549) | 2.45168297 |
| 37 | Basal cell carcinoma (HP:0002671) | 2.43894571 |
| 38 | Neoplasm of the oral cavity (HP:0100649) | 2.43103337 |
| 39 | Homocystinuria (HP:0002156) | 2.42824812 |
| 40 | Abnormality of homocysteine metabolism (HP:0010919) | 2.42824812 |
| 41 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.42261272 |
| 42 | Sloping forehead (HP:0000340) | 2.42042482 |
| 43 | Supernumerary spleens (HP:0009799) | 2.40128130 |
| 44 | Flat occiput (HP:0005469) | 2.38964438 |
| 45 | Prominent nose (HP:0000448) | 2.38582391 |
| 46 | Biliary tract neoplasm (HP:0100574) | 2.38260407 |
| 47 | Shoulder girdle muscle weakness (HP:0003547) | 2.37137462 |
| 48 | Neoplasm of the pancreas (HP:0002894) | 2.35568802 |
| 49 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.35317306 |
| 50 | Atresia of the external auditory canal (HP:0000413) | 2.34706309 |
| 51 | Abnormality of the preputium (HP:0100587) | 2.34431565 |
| 52 | Multiple enchondromatosis (HP:0005701) | 2.34256300 |
| 53 | Rough bone trabeculation (HP:0100670) | 2.32409807 |
| 54 | Duodenal stenosis (HP:0100867) | 2.31691327 |
| 55 | Small intestinal stenosis (HP:0012848) | 2.31691327 |
| 56 | Methylmalonic acidemia (HP:0002912) | 2.31241383 |
| 57 | Absent radius (HP:0003974) | 2.28926693 |
| 58 | Cafe-au-lait spot (HP:0000957) | 2.24377313 |
| 59 | Abnormal lung lobation (HP:0002101) | 2.22521815 |
| 60 | Oral leukoplakia (HP:0002745) | 2.21910374 |
| 61 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.19571580 |
| 62 | Abnormality of the pons (HP:0007361) | 2.18297059 |
| 63 | High pitched voice (HP:0001620) | 2.17412484 |
| 64 | Absent thumb (HP:0009777) | 2.16327235 |
| 65 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.16229852 |
| 66 | Short 4th metacarpal (HP:0010044) | 2.16229852 |
| 67 | Spinal muscular atrophy (HP:0007269) | 2.15635272 |
| 68 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.15314189 |
| 69 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.15314189 |
| 70 | Facial hemangioma (HP:0000329) | 2.13480598 |
| 71 | Triphalangeal thumb (HP:0001199) | 2.13297840 |
| 72 | Neoplasm of striated muscle (HP:0009728) | 2.12158851 |
| 73 | Papillary thyroid carcinoma (HP:0002895) | 2.11894954 |
| 74 | Nephroblastoma (Wilms tumor) (HP:0002667) | 2.11163055 |
| 75 | Aplasia involving forearm bones (HP:0009822) | 2.09136842 |
| 76 | Absent forearm bone (HP:0003953) | 2.09136842 |
| 77 | Abnormality of glycolysis (HP:0004366) | 2.08213698 |
| 78 | Hypoplasia of the pons (HP:0012110) | 2.08000951 |
| 79 | Neoplasm of the colon (HP:0100273) | 2.06678021 |
| 80 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.06160519 |
| 81 | Premature graying of hair (HP:0002216) | 2.06143823 |
| 82 | Megaloblastic anemia (HP:0001889) | 2.04527537 |
| 83 | Long eyelashes (HP:0000527) | 2.02548413 |
| 84 | Increased serum pyruvate (HP:0003542) | 2.02506106 |
| 85 | Cutaneous melanoma (HP:0012056) | 2.02163015 |
| 86 | Ovarian neoplasm (HP:0100615) | 2.01568646 |
| 87 | Neoplasm of the adrenal cortex (HP:0100641) | 2.01089964 |
| 88 | Embryonal renal neoplasm (HP:0011794) | 2.00159768 |
| 89 | Abnormal number of incisors (HP:0011064) | 1.98423817 |
| 90 | Amaurosis fugax (HP:0100576) | 1.97801944 |
| 91 | Reticulocytopenia (HP:0001896) | 1.94549998 |
| 92 | Tongue fasciculations (HP:0001308) | 1.93160410 |
| 93 | Abnormality of alanine metabolism (HP:0010916) | 1.92906605 |
| 94 | Hyperalaninemia (HP:0003348) | 1.92906605 |
| 95 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.92906605 |
| 96 | Neoplasm of the small intestine (HP:0100833) | 1.91940165 |
| 97 | Clubbing of toes (HP:0100760) | 1.91020260 |
| 98 | Abnormality of the carotid arteries (HP:0005344) | 1.90968754 |
| 99 | Freckling (HP:0001480) | 1.89050721 |
| 100 | Cellular immunodeficiency (HP:0005374) | 1.88605546 |
| 101 | Gastrointestinal carcinoma (HP:0002672) | 1.88598642 |
| 102 | Malignant gastrointestinal tract tumors (HP:0006749) | 1.88598642 |
| 103 | Uterine neoplasm (HP:0010784) | 1.88162993 |
| 104 | Abnormality of serum amino acid levels (HP:0003112) | 1.87722840 |
| 105 | Abnormality of the duodenum (HP:0002246) | 1.87487896 |
| 106 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.86529462 |
| 107 | Spastic diplegia (HP:0001264) | 1.86471782 |
| 108 | Overlapping toe (HP:0001845) | 1.86253674 |
| 109 | Neoplasm of the rectum (HP:0100743) | 1.85847994 |
| 110 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.85475797 |
| 111 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.84881606 |
| 112 | Absent epiphyses (HP:0010577) | 1.84881606 |
| 113 | Progressive external ophthalmoplegia (HP:0000590) | 1.82282356 |
| 114 | Deep philtrum (HP:0002002) | 1.80728248 |
| 115 | Neoplasm of the adrenal gland (HP:0100631) | 1.80349733 |
| 116 | Missing ribs (HP:0000921) | 1.80276263 |
| 117 | Embryonal neoplasm (HP:0002898) | 1.80117154 |
| 118 | Acute myeloid leukemia (HP:0004808) | 1.79534322 |
| 119 | 11 pairs of ribs (HP:0000878) | 1.79004519 |
| 120 | Squamous cell carcinoma (HP:0002860) | 1.78117094 |
| 121 | Choanal atresia (HP:0000453) | 1.77978776 |
| 122 | Low anterior hairline (HP:0000294) | 1.77119050 |
| 123 | Tracheoesophageal fistula (HP:0002575) | 1.77062523 |
| 124 | Female pseudohermaphroditism (HP:0010458) | 1.76478753 |
| 125 | Thyroid carcinoma (HP:0002890) | 1.76028445 |
| 126 | Bone marrow hypocellularity (HP:0005528) | 1.75591818 |
| 127 | Abnormal spermatogenesis (HP:0008669) | 1.75401499 |
| 128 | Abnormality of chromosome segregation (HP:0002916) | 1.73250731 |
| 129 | Duplicated collecting system (HP:0000081) | 1.73178442 |
| 130 | Abnormality of the calcaneus (HP:0008364) | 1.73102018 |
| 131 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.72665895 |
| 132 | Horseshoe kidney (HP:0000085) | 1.72522644 |
| 133 | CNS hypomyelination (HP:0003429) | 1.71784443 |
| 134 | Shawl scrotum (HP:0000049) | 1.71764047 |
| 135 | Microvesicular hepatic steatosis (HP:0001414) | 1.70574600 |
| 136 | Short middle phalanx of the 5th finger (HP:0004220) | 1.70309673 |
| 137 | Abnormal biliary tract morphology (HP:0012440) | 1.66370826 |
| 138 | Curly hair (HP:0002212) | 1.65974504 |
| 139 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.60857000 |
| 140 | Small hand (HP:0200055) | 1.60184492 |
| 141 | Arteriovenous malformation (HP:0100026) | 1.58333906 |
| 142 | Macrocytic anemia (HP:0001972) | 1.57633603 |
| 143 | Limb hypertonia (HP:0002509) | 1.57225895 |
| 144 | Breast carcinoma (HP:0003002) | 1.55663102 |
| 145 | Hepatoblastoma (HP:0002884) | 1.53423214 |
| 146 | Hyperglycinemia (HP:0002154) | 1.53282586 |
| 147 | Skull defect (HP:0001362) | 1.51076234 |
| 148 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.49653555 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CDC7 | 4.91057592 |
| 2 | WEE1 | 4.41233924 |
| 3 | BUB1 | 3.97685798 |
| 4 | NEK2 | 3.33519514 |
| 5 | NEK1 | 3.12505291 |
| 6 | TSSK6 | 3.01337841 |
| 7 | BRSK2 | 2.70701463 |
| 8 | PBK | 2.62128773 |
| 9 | ACVR1B | 2.44354017 |
| 10 | CDK12 | 2.42098506 |
| 11 | TTK | 2.41504491 |
| 12 | TAF1 | 2.37959641 |
| 13 | SRPK1 | 2.30026567 |
| 14 | EIF2AK1 | 2.24970267 |
| 15 | MKNK1 | 2.21362915 |
| 16 | PLK3 | 2.14335407 |
| 17 | PLK1 | 2.00701333 |
| 18 | CCNB1 | 1.94000019 |
| 19 | MST4 | 1.87159933 |
| 20 | ATR | 1.86628109 |
| 21 | BRSK1 | 1.82411774 |
| 22 | PLK4 | 1.80738597 |
| 23 | PASK | 1.70955039 |
| 24 | PNCK | 1.66644598 |
| 25 | PDK4 | 1.60666921 |
| 26 | PDK3 | 1.60666921 |
| 27 | MKNK2 | 1.60654310 |
| 28 | AURKB | 1.59005097 |
| 29 | SCYL2 | 1.56026863 |
| 30 | CHEK1 | 1.54774827 |
| 31 | MAP3K13 | 1.54277195 |
| 32 | CHEK2 | 1.53489291 |
| 33 | CDK7 | 1.43766663 |
| 34 | RPS6KB2 | 1.40794179 |
| 35 | CDK4 | 1.40368774 |
| 36 | BCR | 1.38331902 |
| 37 | EEF2K | 1.37784822 |
| 38 | STK10 | 1.34050957 |
| 39 | EIF2AK3 | 1.32465232 |
| 40 | MAP3K8 | 1.22136433 |
| 41 | TNIK | 1.20422111 |
| 42 | ATM | 1.17743994 |
| 43 | RPS6KA4 | 1.16145626 |
| 44 | BRD4 | 1.13181392 |
| 45 | CDK2 | 1.08132288 |
| 46 | MAP3K10 | 1.05890886 |
| 47 | AURKA | 1.05819939 |
| 48 | ALK | 1.05206338 |
| 49 | TRIM28 | 1.05038328 |
| 50 | WNK3 | 1.04582811 |
| 51 | MELK | 1.04559953 |
| 52 | TGFBR1 | 1.03335861 |
| 53 | EPHA2 | 1.03194538 |
| 54 | VRK1 | 0.99287870 |
| 55 | PAK4 | 0.93352936 |
| 56 | DYRK3 | 0.92677245 |
| 57 | PKN2 | 0.91476825 |
| 58 | NLK | 0.90184809 |
| 59 | STK3 | 0.89700154 |
| 60 | ZAK | 0.87478975 |
| 61 | FLT3 | 0.87063507 |
| 62 | BMPR1B | 0.86421363 |
| 63 | CDK6 | 0.85585743 |
| 64 | CDK1 | 0.84796719 |
| 65 | MAP3K14 | 0.84161069 |
| 66 | STK4 | 0.78371685 |
| 67 | EIF2AK2 | 0.77572772 |
| 68 | PDK2 | 0.77399487 |
| 69 | TLK1 | 0.77103143 |
| 70 | ERBB4 | 0.76365308 |
| 71 | STK16 | 0.73827388 |
| 72 | STK39 | 0.73494058 |
| 73 | CSNK1G1 | 0.73403426 |
| 74 | CAMK1G | 0.72268021 |
| 75 | CAMK1D | 0.69036204 |
| 76 | CSNK2A2 | 0.68834598 |
| 77 | FGFR1 | 0.68755458 |
| 78 | MTOR | 0.68171716 |
| 79 | CLK1 | 0.66426219 |
| 80 | STK24 | 0.65943437 |
| 81 | AKT3 | 0.61807003 |
| 82 | CDK3 | 0.60720385 |
| 83 | LATS1 | 0.59969602 |
| 84 | TESK2 | 0.59627061 |
| 85 | CSNK1E | 0.56399043 |
| 86 | PRKDC | 0.54271152 |
| 87 | PIM1 | 0.51822679 |
| 88 | TESK1 | 0.50638144 |
| 89 | CSNK2A1 | 0.50073499 |
| 90 | PLK2 | 0.48840124 |
| 91 | VRK2 | 0.47018521 |
| 92 | OXSR1 | 0.46882709 |
| 93 | NME1 | 0.46106654 |
| 94 | PAK1 | 0.44780273 |
| 95 | LATS2 | 0.43946179 |
| 96 | CSNK1D | 0.42819986 |
| 97 | BRAF | 0.41078321 |
| 98 | MAPK14 | 0.40508042 |
| 99 | OBSCN | 0.39786443 |
| 100 | PRKCI | 0.39046100 |
| 101 | MAPKAPK5 | 0.38718069 |
| 102 | MAP3K4 | 0.38400289 |
| 103 | STK38L | 0.37834675 |
| 104 | MARK3 | 0.37045231 |
| 105 | YES1 | 0.35846925 |
| 106 | RPS6KB1 | 0.35607503 |
| 107 | DAPK1 | 0.35217309 |
| 108 | ERBB3 | 0.34292991 |
| 109 | SMG1 | 0.34109944 |
| 110 | GSK3B | 0.33326423 |
| 111 | MET | 0.31345125 |
| 112 | CDK8 | 0.31056857 |
| 113 | NUAK1 | 0.30598847 |
| 114 | MAP2K3 | 0.29205310 |
| 115 | AKT2 | 0.28002254 |
| 116 | PAK2 | 0.27102577 |
| 117 | MAPK10 | 0.23186301 |
| 118 | NEK9 | 0.23082006 |
| 119 | MAPK1 | 0.22997894 |
| 120 | LRRK2 | 0.22476128 |
| 121 | CSNK1G3 | 0.19684839 |
| 122 | CSNK1A1L | 0.19682648 |
| 123 | AKT1 | 0.19628433 |
| 124 | RPS6KA5 | 0.19353758 |
| 125 | MAPK8 | 0.18956949 |
| 126 | MAPK9 | 0.18043312 |
| 127 | TTN | 0.17023069 |
| 128 | KSR1 | 0.15946578 |
| 129 | NME2 | 0.15143807 |
| 130 | MAP3K5 | 0.14890152 |
| 131 | ZAP70 | 0.14488611 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.48179769 |
| 2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.16040240 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 4.11114154 |
| 4 | RNA transport_Homo sapiens_hsa03013 | 3.76717518 |
| 5 | Spliceosome_Homo sapiens_hsa03040 | 3.44747980 |
| 6 | Cell cycle_Homo sapiens_hsa04110 | 3.34568439 |
| 7 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.82652042 |
| 8 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.73502747 |
| 9 | Base excision repair_Homo sapiens_hsa03410 | 2.62299093 |
| 10 | RNA polymerase_Homo sapiens_hsa03020 | 2.62291645 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.61797015 |
| 12 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.56149099 |
| 13 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.42834993 |
| 14 | Proteasome_Homo sapiens_hsa03050 | 2.29852987 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 2.19649473 |
| 16 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.12570490 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.07696728 |
| 18 | * RNA degradation_Homo sapiens_hsa03018 | 1.86012487 |
| 19 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.79148116 |
| 20 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.70246064 |
| 21 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.67981297 |
| 22 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.66921077 |
| 23 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.64715937 |
| 24 | Protein export_Homo sapiens_hsa03060 | 1.58447265 |
| 25 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.54666635 |
| 26 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.52284621 |
| 27 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.48073872 |
| 28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.46106401 |
| 29 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.36655830 |
| 30 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.36303500 |
| 31 | Ribosome_Homo sapiens_hsa03010 | 1.30650096 |
| 32 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.24876492 |
| 33 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.24007635 |
| 34 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.17695221 |
| 35 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.12156973 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.09644312 |
| 37 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 1.01116564 |
| 38 | HTLV-I infection_Homo sapiens_hsa05166 | 0.96081467 |
| 39 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.96047446 |
| 40 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.95338434 |
| 41 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.94090505 |
| 42 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.93462663 |
| 43 | Thyroid cancer_Homo sapiens_hsa05216 | 0.92507342 |
| 44 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.84981803 |
| 45 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.83873530 |
| 46 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.82648070 |
| 47 | Colorectal cancer_Homo sapiens_hsa05210 | 0.82049601 |
| 48 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.80349832 |
| 49 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.79770530 |
| 50 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.79764689 |
| 51 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.79090606 |
| 52 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.77756429 |
| 53 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.74797967 |
| 54 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.68969027 |
| 55 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.66923377 |
| 56 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.65167532 |
| 57 | Adherens junction_Homo sapiens_hsa04520 | 0.65087998 |
| 58 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.64073122 |
| 59 | Huntingtons disease_Homo sapiens_hsa05016 | 0.60883889 |
| 60 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.57996184 |
| 61 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.55817861 |
| 62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.53819799 |
| 63 | Alcoholism_Homo sapiens_hsa05034 | 0.53717830 |
| 64 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.52706428 |
| 65 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.50400989 |
| 66 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.48894208 |
| 67 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.48777367 |
| 68 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.48012490 |
| 69 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.47055053 |
| 70 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.46422381 |
| 71 | Carbon metabolism_Homo sapiens_hsa01200 | 0.45944536 |
| 72 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.45694244 |
| 73 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.43439888 |
| 74 | Prostate cancer_Homo sapiens_hsa05215 | 0.43274845 |
| 75 | Legionellosis_Homo sapiens_hsa05134 | 0.43133132 |
| 76 | Tight junction_Homo sapiens_hsa04530 | 0.42955814 |
| 77 | Parkinsons disease_Homo sapiens_hsa05012 | 0.42166576 |
| 78 | Endometrial cancer_Homo sapiens_hsa05213 | 0.40923091 |
| 79 | Pathways in cancer_Homo sapiens_hsa05200 | 0.40804419 |
| 80 | Viral myocarditis_Homo sapiens_hsa05416 | 0.39819387 |
| 81 | Hepatitis B_Homo sapiens_hsa05161 | 0.39695338 |
| 82 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.39480525 |
| 83 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.39249076 |
| 84 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.38882877 |
| 85 | Lysine degradation_Homo sapiens_hsa00310 | 0.38526528 |
| 86 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.38158950 |
| 87 | Metabolic pathways_Homo sapiens_hsa01100 | 0.37491219 |
| 88 | Bladder cancer_Homo sapiens_hsa05219 | 0.37157480 |
| 89 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.37062358 |
| 90 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.34948129 |
| 91 | Apoptosis_Homo sapiens_hsa04210 | 0.34529104 |
| 92 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.34372140 |
| 93 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.34081954 |
| 94 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.33467243 |
| 95 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.33346879 |
| 96 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.33308908 |
| 97 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.30512760 |
| 98 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.30328429 |
| 99 | Melanoma_Homo sapiens_hsa05218 | 0.29175217 |
| 100 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.28966526 |
| 101 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.28157392 |
| 102 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.27988766 |
| 103 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.27264380 |
| 104 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.26184742 |
| 105 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.25151721 |
| 106 | Peroxisome_Homo sapiens_hsa04146 | 0.24748740 |
| 107 | Shigellosis_Homo sapiens_hsa05131 | 0.24642508 |
| 108 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.24637372 |
| 109 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.24567996 |
| 110 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.22903336 |
| 111 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.22358226 |
| 112 | Influenza A_Homo sapiens_hsa05164 | 0.22233546 |
| 113 | Measles_Homo sapiens_hsa05162 | 0.22191071 |
| 114 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.21766925 |
| 115 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.21218384 |
| 116 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.20852500 |
| 117 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.20803385 |
| 118 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.20530951 |
| 119 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.19758349 |
| 120 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.19506451 |
| 121 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.19499484 |
| 122 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.17287267 |
| 123 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.17225934 |
| 124 | Glioma_Homo sapiens_hsa05214 | 0.17123620 |
| 125 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.16873182 |
| 126 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.15690719 |
| 127 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.14934952 |
| 128 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.14878519 |
| 129 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.14369306 |
| 130 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.13172119 |
| 131 | Alzheimers disease_Homo sapiens_hsa05010 | 0.12575531 |
| 132 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.12008369 |
| 133 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.11813486 |
| 134 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.11721239 |
| 135 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.11466702 |
| 136 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.11323371 |
| 137 | Circadian rhythm_Homo sapiens_hsa04710 | 0.10472606 |

