SKP1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.61749326
2cytidine deamination (GO:0009972)7.37968310
3cytidine metabolic process (GO:0046087)7.37968310
4cytidine catabolic process (GO:0006216)7.37968310
5pyrimidine ribonucleoside catabolic process (GO:0046133)6.56193320
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.81230461
7sequestering of actin monomers (GO:0042989)4.27547441
8platelet dense granule organization (GO:0060155)4.17154691
9Arp2/3 complex-mediated actin nucleation (GO:0034314)4.00973634
10actin nucleation (GO:0045010)3.66512732
11negative regulation of calcium ion transport into cytosol (GO:0010523)3.60886096
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.59171023
13protein neddylation (GO:0045116)3.52738199
14DNA demethylation (GO:0080111)3.52038806
15response to pheromone (GO:0019236)3.51013142
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45485695
17behavioral response to nicotine (GO:0035095)3.40203894
18positive regulation of calcium-mediated signaling (GO:0050850)3.39031419
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.38907022
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.38907022
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.37075881
22ATP synthesis coupled proton transport (GO:0015986)3.37075881
23proteasome assembly (GO:0043248)3.28457750
24negative regulation of mast cell activation (GO:0033004)3.27559790
25anterograde synaptic vesicle transport (GO:0048490)3.23526775
26nonmotile primary cilium assembly (GO:0035058)3.20514119
27synapsis (GO:0007129)3.19848087
28DNA dealkylation (GO:0035510)3.16424872
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.16112588
30piRNA metabolic process (GO:0034587)3.11289657
31positive regulation of interleukin-8 secretion (GO:2000484)3.09365165
32pyrimidine nucleoside catabolic process (GO:0046135)3.06164442
33fucose catabolic process (GO:0019317)3.06075926
34L-fucose metabolic process (GO:0042354)3.06075926
35L-fucose catabolic process (GO:0042355)3.06075926
36kidney morphogenesis (GO:0060993)3.04194534
37positive regulation of defense response to virus by host (GO:0002230)3.00446502
38collecting duct development (GO:0072044)2.96496537
39eosinophil chemotaxis (GO:0048245)2.96431685
40pyrimidine-containing compound catabolic process (GO:0072529)2.95434386
41regulation of cellular amino acid metabolic process (GO:0006521)2.90692920
42respiratory electron transport chain (GO:0022904)2.88024857
43protein polyglutamylation (GO:0018095)2.87940664
44electron transport chain (GO:0022900)2.86077136
45water-soluble vitamin biosynthetic process (GO:0042364)2.85555035
46positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.85399789
47regulation of T cell receptor signaling pathway (GO:0050856)2.84468113
48protein complex biogenesis (GO:0070271)2.81935505
49regulation of B cell receptor signaling pathway (GO:0050855)2.80682135
50regulation of interleukin-8 secretion (GO:2000482)2.74226249
51negative regulation by host of viral transcription (GO:0043922)2.73776889
52detection of light stimulus involved in sensory perception (GO:0050962)2.73204530
53detection of light stimulus involved in visual perception (GO:0050908)2.73204530
54positive regulation of interleukin-1 beta secretion (GO:0050718)2.72974660
55negative regulation of telomere maintenance (GO:0032205)2.71198050
56positive regulation of natural killer cell mediated immunity (GO:0002717)2.71029537
57eosinophil migration (GO:0072677)2.68867356
58regulation of interleukin-1 beta secretion (GO:0050706)2.61488894
59iron-sulfur cluster assembly (GO:0016226)2.60447164
60metallo-sulfur cluster assembly (GO:0031163)2.60447164
61male meiosis (GO:0007140)2.60394005
62regulation of calcium-mediated signaling (GO:0050848)2.60248061
63negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.59798976
64male meiosis I (GO:0007141)2.59760211
65negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.59753516
66metanephric tubule development (GO:0072170)2.59043901
67metanephric nephron tubule development (GO:0072234)2.59043901
68positive regulation of interleukin-1 secretion (GO:0050716)2.58761049
69ubiquinone biosynthetic process (GO:0006744)2.57444500
70negative regulation of heart rate (GO:0010459)2.57114847
71DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.55994913
72negative regulation of oxidoreductase activity (GO:0051354)2.55789441
73indolalkylamine metabolic process (GO:0006586)2.53787370
74dopamine transport (GO:0015872)2.52199494
75lung epithelium development (GO:0060428)2.52013353
76negative T cell selection (GO:0043383)2.51973647
77T cell migration (GO:0072678)2.49673096
78regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.48704348
79epithelial cilium movement (GO:0003351)2.47253755
80lymphocyte chemotaxis (GO:0048247)2.46916988
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46323799
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.46323799
83NADH dehydrogenase complex assembly (GO:0010257)2.46323799
84regulation of lymphocyte chemotaxis (GO:1901623)2.46179026
85positive regulation of tolerance induction (GO:0002645)2.44951582
86regulation of chronic inflammatory response (GO:0002676)2.44388333
87positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.44311912
88mitochondrial respiratory chain complex assembly (GO:0033108)2.44059280
89signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.44025948
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.44025948
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.44025948
92proton transport (GO:0015992)2.43355042
93hydrogen ion transmembrane transport (GO:1902600)2.43259640
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42488285
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42488285
96positive regulation of lymphocyte migration (GO:2000403)2.42248348
97ubiquinone metabolic process (GO:0006743)2.41518065
98base-excision repair, AP site formation (GO:0006285)2.41471108
99signal peptide processing (GO:0006465)2.39477717
100positive regulation of cAMP-mediated signaling (GO:0043950)2.38975994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.63066569
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.61421627
3ZNF274_21170338_ChIP-Seq_K562_Hela3.29396381
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.01821639
5VDR_22108803_ChIP-Seq_LS180_Human2.95628873
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92214798
7EZH2_22144423_ChIP-Seq_EOC_Human2.70328865
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.69330371
9IGF1R_20145208_ChIP-Seq_DFB_Human2.61354942
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57797929
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52711687
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24957695
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20573197
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15958609
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.14485955
16TAF15_26573619_Chip-Seq_HEK293_Human2.07288186
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01061060
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00248608
19VDR_23849224_ChIP-Seq_CD4+_Human1.91233443
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86580357
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.81836785
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.78339719
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67908487
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67652432
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65810882
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62886470
27ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58974593
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58531749
29FUS_26573619_Chip-Seq_HEK293_Human1.56166842
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.55856661
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55419852
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.51885345
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47728832
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47196135
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.46310380
36EWS_26573619_Chip-Seq_HEK293_Human1.45571796
37BCAT_22108803_ChIP-Seq_LS180_Human1.45044862
38POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44852132
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42767498
40AR_20517297_ChIP-Seq_VCAP_Human1.41786728
41P300_19829295_ChIP-Seq_ESCs_Human1.41184017
42FOXP3_21729870_ChIP-Seq_TREG_Human1.40107723
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39660906
44MYC_18940864_ChIP-ChIP_HL60_Human1.39079611
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35673126
46GBX2_23144817_ChIP-Seq_PC3_Human1.35149263
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.34725450
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34725450
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33005661
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32413437
51TP53_22573176_ChIP-Seq_HFKS_Human1.32401541
52ELK1_19687146_ChIP-ChIP_HELA_Human1.32225165
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32193967
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30248766
55GATA3_26560356_Chip-Seq_TH2_Human1.26658989
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.26424427
57NCOR_22424771_ChIP-Seq_293T_Human1.25119451
58GATA3_21878914_ChIP-Seq_MCF-7_Human1.24541714
59ER_23166858_ChIP-Seq_MCF-7_Human1.24109888
60NANOG_19829295_ChIP-Seq_ESCs_Human1.24043836
61SOX2_19829295_ChIP-Seq_ESCs_Human1.24043836
62MYC_19829295_ChIP-Seq_ESCs_Human1.21705834
63RNF2_27304074_Chip-Seq_NSC_Mouse1.21368510
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19804736
65PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19723858
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17794845
67PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.17448343
68ERG_20517297_ChIP-Seq_VCAP_Human1.16256452
69TAF2_19829295_ChIP-Seq_ESCs_Human1.16034482
70IRF1_19129219_ChIP-ChIP_H3396_Human1.15453720
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15364490
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09443447
73SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08198515
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05219505
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05200584
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05106491
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.05023147
78TCF4_22108803_ChIP-Seq_LS180_Human1.05008953
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05007537
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03963113
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.02585977
82NANOG_20526341_ChIP-Seq_ESCs_Human1.02117161
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01177902
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00880402
85CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00165694
86GATA6_21074721_ChIP-Seq_CACO-2_Human0.99641271
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97352323
88CBP_20019798_ChIP-Seq_JUKART_Human0.97352323
89SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97306823
90PHF8_20622853_ChIP-Seq_HELA_Human0.97127879
91ERA_21632823_ChIP-Seq_H3396_Human0.97027000
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96546778
93HTT_18923047_ChIP-ChIP_STHdh_Human0.96532127
94REST_21632747_ChIP-Seq_MESCs_Mouse0.96128905
95GATA3_27048872_Chip-Seq_THYMUS_Human0.95546382
96EZH2_27294783_Chip-Seq_NPCs_Mouse0.95020257
97RBPJ_21746931_ChIP-Seq_IB4_Human0.94889736
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94517661
99HOXB7_26014856_ChIP-Seq_BT474_Human0.93024869
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92996705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.94059386
2MP0005671_abnormal_response_to3.26125728
3MP0008877_abnormal_DNA_methylation2.72017270
4MP0002736_abnormal_nociception_after2.49053041
5MP0001968_abnormal_touch/_nociception2.35912543
6MP0005646_abnormal_pituitary_gland2.34952605
7MP0002653_abnormal_ependyma_morphology2.32128681
8MP0001984_abnormal_olfaction2.24218639
9MP0009785_altered_susceptibility_to2.10573016
10MP0005551_abnormal_eye_electrophysiolog2.02046832
11MP0002163_abnormal_gland_morphology2.01582225
12MP0006276_abnormal_autonomic_nervous1.95819822
13MP0001346_abnormal_lacrimal_gland1.92117288
14MP0003787_abnormal_imprinting1.91444853
15MP0000372_irregular_coat_pigmentation1.91056867
16MP0005645_abnormal_hypothalamus_physiol1.86495681
17MP0001529_abnormal_vocalization1.81855737
18MP0003011_delayed_dark_adaptation1.75797548
19MP0006072_abnormal_retinal_apoptosis1.72658925
20MP0002837_dystrophic_cardiac_calcinosis1.69281767
21MP0004742_abnormal_vestibular_system1.67132374
22MP0008872_abnormal_physiological_respon1.65113914
23MP0008789_abnormal_olfactory_epithelium1.64129414
24MP0003122_maternal_imprinting1.64075890
25MP0001905_abnormal_dopamine_level1.57377749
26MP0002876_abnormal_thyroid_physiology1.54882223
27MP0008875_abnormal_xenobiotic_pharmacok1.54139369
28MP0001835_abnormal_antigen_presentation1.50713238
29MP0004142_abnormal_muscle_tone1.48333399
30MP0002148_abnormal_hypersensitivity_rea1.46010253
31MP0006082_CNS_inflammation1.45909553
32MP0005253_abnormal_eye_physiology1.45202959
33MP0003195_calcinosis1.41319697
34MP0006292_abnormal_olfactory_placode1.40343827
35MP0009745_abnormal_behavioral_response1.39330208
36MP0004885_abnormal_endolymph1.34925683
37MP0001919_abnormal_reproductive_system1.34105296
38MP0009333_abnormal_splenocyte_physiolog1.33661405
39MP0010386_abnormal_urinary_bladder1.33106869
40MP0002822_catalepsy1.32845882
41MP0002277_abnormal_respiratory_mucosa1.30979679
42MP0003866_abnormal_defecation1.28712590
43MP0005248_abnormal_Harderian_gland1.27983000
44MP0001970_abnormal_pain_threshold1.27955703
45MP0003121_genomic_imprinting1.26533126
46MP0005389_reproductive_system_phenotype1.23745833
47MP0005394_taste/olfaction_phenotype1.23289852
48MP0005499_abnormal_olfactory_system1.23289852
49MP0002733_abnormal_thermal_nociception1.22753428
50MP0002735_abnormal_chemical_nociception1.20113230
51MP0002166_altered_tumor_susceptibility1.19539025
52MP0005379_endocrine/exocrine_gland_phen1.18855914
53MP0002272_abnormal_nervous_system1.18377486
54MP0000427_abnormal_hair_cycle1.14601550
55MP0001800_abnormal_humoral_immune1.14411715
56MP0005410_abnormal_fertilization1.14277271
57MP0002693_abnormal_pancreas_physiology1.12175970
58MP0005387_immune_system_phenotype1.09839505
59MP0001790_abnormal_immune_system1.09839505
60MP0002723_abnormal_immune_serum1.09085525
61MP0002095_abnormal_skin_pigmentation1.08863850
62MP0001873_stomach_inflammation1.08491079
63MP0005000_abnormal_immune_tolerance1.07087847
64MP0008058_abnormal_DNA_repair1.06776720
65MP0001986_abnormal_taste_sensitivity1.05537228
66MP0002006_tumorigenesis1.04881689
67MP0009046_muscle_twitch1.04532113
68MP0005075_abnormal_melanosome_morpholog1.03931626
69MP0000569_abnormal_digit_pigmentation1.03731678
70MP0005377_hearing/vestibular/ear_phenot1.03557273
71MP0003878_abnormal_ear_physiology1.03557273
72MP0003786_premature_aging1.02561617
73MP0006036_abnormal_mitochondrial_physio1.00306600
74MP0001485_abnormal_pinna_reflex0.99912302
75MP0005025_abnormal_response_to0.98912253
76MP0002572_abnormal_emotion/affect_behav0.97895591
77MP0002420_abnormal_adaptive_immunity0.97054149
78MP0001764_abnormal_homeostasis0.96785147
79MP0003646_muscle_fatigue0.93374743
80MP0003137_abnormal_impulse_conducting0.93265134
81MP0003763_abnormal_thymus_physiology0.92964359
82MP0001819_abnormal_immune_cell0.92485092
83MP0003283_abnormal_digestive_organ0.91891228
84MP0004145_abnormal_muscle_electrophysio0.90376094
85MP0002557_abnormal_social/conspecific_i0.89783912
86MP0001486_abnormal_startle_reflex0.87042311
87MP0005195_abnormal_posterior_eye0.86999862
88MP0002064_seizures0.86875166
89MP0009764_decreased_sensitivity_to0.86840931
90MP0001440_abnormal_grooming_behavior0.86442933
91MP0002160_abnormal_reproductive_system0.82290657
92MP0004924_abnormal_behavior0.80464158
93MP0005386_behavior/neurological_phenoty0.80464158
94MP0001929_abnormal_gametogenesis0.80059476
95MP0002734_abnormal_mechanical_nocicepti0.78809760
96MP0002067_abnormal_sensory_capabilities0.77126362
97MP0005084_abnormal_gallbladder_morpholo0.74951662
98MP0002638_abnormal_pupillary_reflex0.74845609
99MP0005636_abnormal_mineral_homeostasis0.74443500
100MP0002138_abnormal_hepatobiliary_system0.74248108

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.34877702
2Acute encephalopathy (HP:0006846)3.78282703
3Abnormal mitochondria in muscle tissue (HP:0008316)3.77436666
4Progressive macrocephaly (HP:0004481)3.73896780
5True hermaphroditism (HP:0010459)3.68273340
6Pancreatic cysts (HP:0001737)3.67611612
7Mitochondrial inheritance (HP:0001427)3.55387402
8Decreased central vision (HP:0007663)3.47176208
9Abnormality of midbrain morphology (HP:0002418)3.43569434
10Molar tooth sign on MRI (HP:0002419)3.43569434
11Aplastic anemia (HP:0001915)3.40873343
12Congenital stationary night blindness (HP:0007642)3.26446939
13Pancreatic fibrosis (HP:0100732)3.25971954
14Increased CSF lactate (HP:0002490)3.14302628
15Hypoproteinemia (HP:0003075)3.12463288
16Absent/shortened dynein arms (HP:0200106)3.09630091
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.09630091
18Stomatitis (HP:0010280)3.04093690
19Abolished electroretinogram (ERG) (HP:0000550)3.03246705
20Absent rod-and cone-mediated responses on ERG (HP:0007688)3.02039073
21Attenuation of retinal blood vessels (HP:0007843)2.95468183
22Abnormality of the renal cortex (HP:0011035)2.89617479
23Generalized aminoaciduria (HP:0002909)2.89062182
24Renal cortical cysts (HP:0000803)2.85191049
25Hepatic necrosis (HP:0002605)2.78232027
26Medial flaring of the eyebrow (HP:0010747)2.77877737
27IgG deficiency (HP:0004315)2.75688135
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.75466941
29Increased IgM level (HP:0003496)2.72838364
30Hepatocellular necrosis (HP:0001404)2.72667380
31Elevated erythrocyte sedimentation rate (HP:0003565)2.72273165
32Optic disc pallor (HP:0000543)2.68462334
33Abnormal rod and cone electroretinograms (HP:0008323)2.64032975
34Nephronophthisis (HP:0000090)2.63647020
35Thyroiditis (HP:0100646)2.57372433
36Cerebral edema (HP:0002181)2.56731705
37Abnormality of T cell number (HP:0011839)2.54354981
38Severe combined immunodeficiency (HP:0004430)2.49541590
39Pendular nystagmus (HP:0012043)2.43007906
40Hypothermia (HP:0002045)2.35974499
41T lymphocytopenia (HP:0005403)2.35896057
423-Methylglutaconic aciduria (HP:0003535)2.35079339
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33591986
44Polydipsia (HP:0001959)2.33034267
45Abnormal drinking behavior (HP:0030082)2.33034267
46Abnormality of the labia minora (HP:0012880)2.27430896
47Autoimmune hemolytic anemia (HP:0001890)2.27336347
48Abnormality of the prostate (HP:0008775)2.22291394
49Abnormality of alanine metabolism (HP:0010916)2.21888427
50Hyperalaninemia (HP:0003348)2.21888427
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21888427
52Polyphagia (HP:0002591)2.20496208
53Abnormality of the renal medulla (HP:0100957)2.19616216
54Failure to thrive in infancy (HP:0001531)2.17363998
55Methylmalonic aciduria (HP:0012120)2.14707555
56Renal Fanconi syndrome (HP:0001994)2.13542689
57Gait imbalance (HP:0002141)2.12633862
58Abnormality of B cell number (HP:0010975)2.12063218
59Pancytopenia (HP:0001876)2.10730078
60Congenital primary aphakia (HP:0007707)2.09790721
61Methylmalonic acidemia (HP:0002912)2.07643395
62Abnormal respiratory epithelium morphology (HP:0012253)2.06888174
63Abnormal respiratory motile cilium morphology (HP:0005938)2.06888174
64Lactic acidosis (HP:0003128)2.06151331
65Ketoacidosis (HP:0001993)2.06048744
66Cystic liver disease (HP:0006706)2.04580353
67Increased serum lactate (HP:0002151)2.03894051
68Hyperglycinemia (HP:0002154)2.03347411
69Nephrogenic diabetes insipidus (HP:0009806)2.01004590
70Increased hepatocellular lipid droplets (HP:0006565)1.96101387
71Type II lissencephaly (HP:0007260)1.95563482
72Colon cancer (HP:0003003)1.95310176
73Increased corneal curvature (HP:0100692)1.92793114
74Keratoconus (HP:0000563)1.92793114
75Male pseudohermaphroditism (HP:0000037)1.90751611
76Abnormality of serum amino acid levels (HP:0003112)1.90547692
77Ketosis (HP:0001946)1.90372245
78Aplasia/hypoplasia of the uterus (HP:0008684)1.88592749
79Lethargy (HP:0001254)1.88015423
80Abnormality of eosinophils (HP:0001879)1.86802085
81Polyuria (HP:0000103)1.85267452
82Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84538715
83Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84538715
84Sclerocornea (HP:0000647)1.83884929
85Lipid accumulation in hepatocytes (HP:0006561)1.83866701
86Hypoalbuminemia (HP:0003073)1.83266956
87Abnormal albumin level (HP:0012116)1.83266956
88Combined immunodeficiency (HP:0005387)1.82987441
89Progressive microcephaly (HP:0000253)1.79460438
90Aplasia/Hypoplasia of the tongue (HP:0010295)1.78827680
91Increased intramyocellular lipid droplets (HP:0012240)1.78608543
92Leukodystrophy (HP:0002415)1.78268972
93X-linked dominant inheritance (HP:0001423)1.77703721
94Respiratory failure (HP:0002878)1.76587417
95Abnormality of T cells (HP:0002843)1.76187893
96B lymphocytopenia (HP:0010976)1.75770897
97Poor suck (HP:0002033)1.75334828
98Furrowed tongue (HP:0000221)1.74541065
99Chronic bronchitis (HP:0004469)1.74516255
100Abnormal respiratory motile cilium physiology (HP:0012261)1.73262047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.75156553
2KDR3.59136991
3FRK3.13104034
4MAP4K23.05511414
5ZAK2.50679636
6BCR2.29584818
7TLK12.27377528
8TESK22.23059061
9WNK32.02207147
10ADRBK21.98614888
11GRK11.90428919
12LIMK11.81039812
13ITK1.80980250
14VRK21.73265416
15BCKDK1.71219572
16NUAK11.69778892
17MAP4K11.66134732
18PINK11.57032724
19VRK11.48274599
20CAMKK21.44429971
21MAPK131.41337614
22CDK191.40046376
23MAP3K91.37032515
24BMPR1B1.33425526
25TEC1.32737585
26CSNK1G31.31243060
27PAK31.28353417
28STK161.27401032
29MAP2K71.26638793
30INSRR1.25592077
31EPHA31.25478742
32CSNK1G21.21826840
33DYRK21.12953802
34TRIM281.11150536
35ERBB31.10873474
36PASK1.10632480
37PLK21.07896577
38MAPKAPK31.04731384
39CSNK1A1L1.03951687
40PRKCQ1.03300586
41SYK0.96053532
42CSNK1G10.94952649
43TESK10.94845524
44EIF2AK10.88797919
45GRK50.88090454
46PRKCE0.87051245
47FES0.84592988
48MST40.82924038
49MAP3K40.81623033
50IRAK40.80404343
51DAPK10.78801730
52WNK40.73274105
53CASK0.72887882
54CAMKK10.71385841
55LCK0.70214968
56PRKCH0.68583269
57IKBKB0.68286250
58CAMK2A0.67964229
59RPS6KA50.67666858
60ADRBK10.67050587
61OXSR10.67011588
62PKN10.66387301
63NME10.65836967
64GRK60.64760789
65LYN0.61776957
66SRPK10.61182569
67TAOK30.59939926
68PIK3CA0.59572468
69SIK30.58122386
70PTK2B0.57879647
71CAMK10.56242308
72EIF2AK30.55993539
73PRKCG0.55568096
74MAP3K120.54961523
75PRKACA0.54092472
76RPS6KA40.53551739
77FER0.53494677
78CAMK2D0.53459560
79PRKCA0.53328222
80SCYL20.53292802
81MYLK0.53103562
82MKNK20.51985955
83PHKG20.51855325
84PHKG10.51855325
85MINK10.51389065
86PLK30.51065781
87OBSCN0.50299299
88MUSK0.50001090
89BTK0.48675421
90IKBKE0.46603876
91IGF1R0.45245389
92MAP2K60.42702994
93GRK70.42049646
94PRKD30.41344466
95CSNK2A10.41281621
96PAK60.40729932
97TIE10.40327870
98MKNK10.40187403
99CSNK1A10.39867346
100ROCK10.37337030

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.63924663
2Primary immunodeficiency_Homo sapiens_hsa053403.53218204
3Protein export_Homo sapiens_hsa030603.45535757
4Oxidative phosphorylation_Homo sapiens_hsa001903.39479283
5Parkinsons disease_Homo sapiens_hsa050122.81386201
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23061769
7Phototransduction_Homo sapiens_hsa047442.12232581
8Autoimmune thyroid disease_Homo sapiens_hsa053202.06919716
9Graft-versus-host disease_Homo sapiens_hsa053322.03937199
10Allograft rejection_Homo sapiens_hsa053301.95852931
11Type I diabetes mellitus_Homo sapiens_hsa049401.88537140
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85397636
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82023845
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74928529
15RNA polymerase_Homo sapiens_hsa030201.74579236
16Collecting duct acid secretion_Homo sapiens_hsa049661.73947373
17Antigen processing and presentation_Homo sapiens_hsa046121.67794783
18Alzheimers disease_Homo sapiens_hsa050101.61403807
19Hematopoietic cell lineage_Homo sapiens_hsa046401.60655194
20Butanoate metabolism_Homo sapiens_hsa006501.60505549
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58555537
22Linoleic acid metabolism_Homo sapiens_hsa005911.57899395
23Huntingtons disease_Homo sapiens_hsa050161.50218393
24Steroid biosynthesis_Homo sapiens_hsa001001.44515386
25Selenocompound metabolism_Homo sapiens_hsa004501.43122246
26Asthma_Homo sapiens_hsa053101.39630754
27Rheumatoid arthritis_Homo sapiens_hsa053231.38820665
28Propanoate metabolism_Homo sapiens_hsa006401.37468749
29Cardiac muscle contraction_Homo sapiens_hsa042601.37375969
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36136429
31Homologous recombination_Homo sapiens_hsa034401.27379014
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.27052779
33Nitrogen metabolism_Homo sapiens_hsa009101.23855305
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17570216
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.14190279
36Sulfur metabolism_Homo sapiens_hsa009201.14180087
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13243676
38Mismatch repair_Homo sapiens_hsa034301.12980254
39Ether lipid metabolism_Homo sapiens_hsa005651.11888504
40One carbon pool by folate_Homo sapiens_hsa006701.10732395
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10126085
42Regulation of autophagy_Homo sapiens_hsa041401.08424697
43Peroxisome_Homo sapiens_hsa041461.07545078
44Olfactory transduction_Homo sapiens_hsa047401.04241659
45Non-homologous end-joining_Homo sapiens_hsa034501.02828030
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01432094
47RNA degradation_Homo sapiens_hsa030180.97495548
48T cell receptor signaling pathway_Homo sapiens_hsa046600.93802975
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92550240
50Fanconi anemia pathway_Homo sapiens_hsa034600.91472961
51Nicotine addiction_Homo sapiens_hsa050330.86270281
52Basal transcription factors_Homo sapiens_hsa030220.86074493
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83979738
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83574081
55Nucleotide excision repair_Homo sapiens_hsa034200.80271642
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78269915
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77611096
58Fatty acid elongation_Homo sapiens_hsa000620.75832082
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.75013423
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74250073
61Chemical carcinogenesis_Homo sapiens_hsa052040.71877475
62Arachidonic acid metabolism_Homo sapiens_hsa005900.69967974
63Purine metabolism_Homo sapiens_hsa002300.69926315
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67911757
65Morphine addiction_Homo sapiens_hsa050320.67563128
66Synaptic vesicle cycle_Homo sapiens_hsa047210.66477784
67Taste transduction_Homo sapiens_hsa047420.66146735
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64919599
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62152129
70Base excision repair_Homo sapiens_hsa034100.62016720
71Pyrimidine metabolism_Homo sapiens_hsa002400.61087117
72Retinol metabolism_Homo sapiens_hsa008300.60528876
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59849920
74Tryptophan metabolism_Homo sapiens_hsa003800.59107045
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58161268
76Metabolic pathways_Homo sapiens_hsa011000.57558172
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56599292
78Salmonella infection_Homo sapiens_hsa051320.56223782
79GABAergic synapse_Homo sapiens_hsa047270.55706507
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.54903890
81DNA replication_Homo sapiens_hsa030300.53047513
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51554245
83Ribosome_Homo sapiens_hsa030100.50340620
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.49824132
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48108647
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47567765
87Measles_Homo sapiens_hsa051620.42498367
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.39518977
89Serotonergic synapse_Homo sapiens_hsa047260.37944781
90Circadian entrainment_Homo sapiens_hsa047130.37233307
91Viral myocarditis_Homo sapiens_hsa054160.36997217
92Ovarian steroidogenesis_Homo sapiens_hsa049130.36973321
93beta-Alanine metabolism_Homo sapiens_hsa004100.36821376
94Insulin secretion_Homo sapiens_hsa049110.36355249
95Vibrio cholerae infection_Homo sapiens_hsa051100.35984706
96Caffeine metabolism_Homo sapiens_hsa002320.35707448
97Systemic lupus erythematosus_Homo sapiens_hsa053220.33565091
98Fat digestion and absorption_Homo sapiens_hsa049750.33169054
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32085738
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31789300

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