ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to kinetochore (GO:0034501)	5.27534466
2	DNA unwinding involved in DNA replication (GO:0006268)	5.24027960
3	nuclear pore organization (GO:0006999)	4.98573575
4	nuclear pore complex assembly (GO:0051292)	4.90081744
5	mitotic metaphase plate congression (GO:0007080)	4.80806336
6	DNA replication initiation (GO:0006270)	4.61889880
7	protein localization to chromosome, centromeric region (GO:0071459)	4.61247799
8	DNA strand elongation involved in DNA replication (GO:0006271)	4.52713801
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.49129365
10	DNA replication checkpoint (GO:0000076)	4.43512191
11	kinetochore organization (GO:0051383)	4.32412889
12	DNA strand elongation (GO:0022616)	4.30897605
13	DNA replication-dependent nucleosome assembly (GO:0006335)	4.28712237
14	DNA replication-dependent nucleosome organization (GO:0034723)	4.28712237
15	mitotic sister chromatid segregation (GO:0000070)	4.22933375
16	metaphase plate congression (GO:0051310)	4.21173182
17	mitotic chromosome condensation (GO:0007076)	4.19285004
18	sister chromatid segregation (GO:0000819)	4.18512569
19	mitotic nuclear envelope disassembly (GO:0007077)	4.17559070
20	mitotic sister chromatid cohesion (GO:0007064)	4.14844497
21	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.10368632
22	regulation of spindle organization (GO:0090224)	4.00527108
23	telomere maintenance via semi-conservative replication (GO:0032201)	3.98477857
24	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.94165879
25	nucleobase biosynthetic process (GO:0046112)	3.90507571
26	CENP-A containing nucleosome assembly (GO:0034080)	3.87819157
27	nuclear envelope disassembly (GO:0051081)	3.87283731
28	membrane disassembly (GO:0030397)	3.87283731
29	chromatin remodeling at centromere (GO:0031055)	3.86491797
30	DNA replication-independent nucleosome organization (GO:0034724)	3.77510041
31	DNA replication-independent nucleosome assembly (GO:0006336)	3.77510041
32	kinetochore assembly (GO:0051382)	3.77416406
33	purine nucleobase biosynthetic process (GO:0009113)	3.77037865
34	pore complex assembly (GO:0046931)	3.76926453
35	mitotic recombination (GO:0006312)	3.74775972
36	attachment of spindle microtubules to kinetochore (GO:0008608)	3.68642055
37	establishment of chromosome localization (GO:0051303)	3.68451025
38	telomere maintenance via recombination (GO:0000722)	3.67278354
39	spindle checkpoint (GO:0031577)	3.66398872
40	regulation of chromosome segregation (GO:0051983)	3.61864371
41	histone exchange (GO:0043486)	3.61209404
42	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.59850671
43	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.59850671
44	negative regulation of chromosome segregation (GO:0051985)	3.58504014
45	IMP biosynthetic process (GO:0006188)	3.54838469
46	regulation of centrosome cycle (GO:0046605)	3.53436580
47	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.52879119
48	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.52879119
49	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.52879119
50	negative regulation of sister chromatid segregation (GO:0033046)	3.52879119
51	protein localization to chromosome (GO:0034502)	3.52070124
52	spindle assembly checkpoint (GO:0071173)	3.50230683
53	regulation of sister chromatid cohesion (GO:0007063)	3.48771872
54	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.48267132
55	DNA ligation (GO:0006266)	3.44703363
56	positive regulation of chromosome segregation (GO:0051984)	3.44682092
57	regulation of mitotic spindle organization (GO:0060236)	3.43781900
58	mitotic spindle checkpoint (GO:0071174)	3.43323744
59	mitotic spindle assembly checkpoint (GO:0007094)	3.43182794
60	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.42913561
61	chromosome condensation (GO:0030261)	3.42165384
62	DNA geometric change (GO:0032392)	3.41969002
63	formation of translation preinitiation complex (GO:0001731)	3.41107419
64	DNA duplex unwinding (GO:0032508)	3.40780183
65	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.40671292
66	pre-miRNA processing (GO:0031054)	3.40270729
67	establishment of integrated proviral latency (GO:0075713)	3.38327292
68	regulation of centriole replication (GO:0046599)	3.37437787
69	replication fork processing (GO:0031297)	3.33967517
70	chromatin assembly or disassembly (GO:0006333)	3.33813416
71	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.31626785
72	ATP-dependent chromatin remodeling (GO:0043044)	3.30481251
73	telomere maintenance via telomere lengthening (GO:0010833)	3.29733865
74	postreplication repair (GO:0006301)	3.29200246
75	regulation of sister chromatid segregation (GO:0033045)	3.29148483
76	regulation of mitotic sister chromatid separation (GO:0010965)	3.29148483
77	regulation of mitotic sister chromatid segregation (GO:0033047)	3.29148483
78	meiotic chromosome segregation (GO:0045132)	3.24993507
79	regulation of RNA export from nucleus (GO:0046831)	3.24942126
80	chromosome segregation (GO:0007059)	3.24262205
81	double-strand break repair via nonhomologous end joining (GO:0006303)	3.24106239
82	non-recombinational repair (GO:0000726)	3.24106239
83	DNA packaging (GO:0006323)	3.18287847
84	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.17531855
85	DNA conformation change (GO:0071103)	3.16991538
86	synapsis (GO:0007129)	3.16327070
87	paraxial mesoderm development (GO:0048339)	3.15150181
88	ribosome assembly (GO:0042255)	3.12287582
89	heterochromatin organization (GO:0070828)	3.11693477
90	regulation of mitotic spindle checkpoint (GO:1903504)	3.09271734
91	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.09271734
92	mitotic G2/M transition checkpoint (GO:0044818)	3.09147632
93	DNA topological change (GO:0006265)	3.09047179
94	regulation of DNA methylation (GO:0044030)	3.09003613
95	folic acid-containing compound biosynthetic process (GO:0009396)	3.06530428
96	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.02828885
97	regulation of DNA endoreduplication (GO:0032875)	3.02488936
98	nuclear envelope organization (GO:0006998)	3.01754961
99	IMP metabolic process (GO:0046040)	2.99971020
100	microtubule depolymerization (GO:0007019)	2.99768315
101	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.99166798
102	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.99166798
103	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.99166798
104	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.96203458
105	translesion synthesis (GO:0019985)	2.94465988
106	DNA strand renaturation (GO:0000733)	2.93946191
107	protein K6-linked ubiquitination (GO:0085020)	2.92959239
108	base-excision repair (GO:0006284)	2.92886578
109	DNA double-strand break processing (GO:0000729)	2.90714837
110	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.89734041
111	regulation of centrosome duplication (GO:0010824)	2.89125606
112	regulation of double-strand break repair (GO:2000779)	2.88966881
113	positive regulation of histone H3-K4 methylation (GO:0051571)	2.88572947
114	negative regulation of RNA splicing (GO:0033119)	2.88543041
115	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.88516312
116	proteasome assembly (GO:0043248)	2.88194659
117	mismatch repair (GO:0006298)	2.87412874
118	telomere maintenance (GO:0000723)	2.86486879
119	telomere organization (GO:0032200)	2.85658502
120	histone-serine phosphorylation (GO:0035404)	2.85375894
121	* mitotic cell cycle (GO:0000278)	2.84187811
122	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)	2.83566442
123	mRNA splicing, via spliceosome (GO:0000398)	2.83566442
124	L-serine metabolic process (GO:0006563)	2.83536927
125	RNA splicing, via transesterification reactions (GO:0000375)	2.83535734
126	ribosome biogenesis (GO:0042254)	2.83175124

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	6.00578008
2	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.68087037
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.04143448
4	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.91440189
5	* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.99551374
6	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.99309606
7	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.97206221
8	* AR_21909140_ChIP-Seq_LNCAP_Human	2.85281961
9	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.74780161
10	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.60221407
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.48040418
12	* MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.47642815
13	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.45719483
14	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.37119507
15	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.32673992
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.30917582
17	XRN2_22483619_ChIP-Seq_HELA_Human	2.19959745
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.18784261
19	* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.17644444
20	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.16053707
21	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.12201244
22	* ETS1_20019798_ChIP-Seq_JURKAT_Human	2.05428304
23	* CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.02841897
24	MYCN_18555785_ChIP-Seq_MESCs_Mouse	2.02678424
25	E2F7_22180533_ChIP-Seq_HELA_Human	11.1626228
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.97576033
27	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.92910787
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.87810888
29	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.84661472
30	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.79367221
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77451612
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.75206036
33	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.71099725
34	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.71005702
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.69044000
36	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.65377032
37	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.64279854
38	* E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.61246918
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.61204735
40	DCP1A_22483619_ChIP-Seq_HELA_Human	1.57317504
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.56265219
42	GABP_19822575_ChIP-Seq_HepG2_Human	1.54333319
43	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.52090882
44	CIITA_25753668_ChIP-Seq_RAJI_Human	1.50503996
45	MYC_22102868_ChIP-Seq_BL_Human	1.49056166
46	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.47493759
47	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.46866123
48	EWS_26573619_Chip-Seq_HEK293_Human	1.44928712
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.43693661
50	* THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.39761541
51	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.38981444
52	KDM5A_27292631_Chip-Seq_BREAST_Human	1.38728082
53	FUS_26573619_Chip-Seq_HEK293_Human	1.37718735
54	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.34907327
55	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.33477525
56	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.32432241
57	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.25187599
58	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.23637168
59	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.21211528
60	* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.19724706
61	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.19348352
62	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.18451512
63	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.17011222
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16858387
65	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.15860268
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.15648600
67	* KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.15553650
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.15037844
69	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.12876638
70	* PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12551152
71	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.09292018
72	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.08639323
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.05992160
74	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.05294307
75	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.04670396
76	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.04553472
77	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.03806574
78	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.03679916
79	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.03670611
80	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.02087364
81	ZNF274_21170338_ChIP-Seq_K562_Hela	1.02003771
82	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.01819313
83	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.00396981
84	MYC_18940864_ChIP-ChIP_HL60_Human	0.99438401
85	* TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.99336512
86	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.97844836
87	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.96745998
88	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.95774999
89	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.90334691
90	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.89538483
91	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.86591818
92	* TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.86070853
93	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.85125268
94	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.84178703
95	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.84111524
96	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.84111524
97	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.84111524
98	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.84006315
99	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.83862778
100	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.83791190
101	TFEB_21752829_ChIP-Seq_HELA_Human	0.82454695
102	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.82393346
103	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.80869032
104	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.80835431
105	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.80113377
106	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.79120221
107	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	0.76926668
108	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.76826409
109	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.76259855
110	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.76127507
111	EZH2_22144423_ChIP-Seq_EOC_Human	0.75643345
112	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.75542465
113	CHD1_26751641_Chip-Seq_LNCaP_Human	0.75179855
114	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.72327054
115	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.70510449
116	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.63295369
117	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.62403627
118	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.60754107
119	IGF1R_20145208_ChIP-Seq_DFB_Human	0.59841838

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	4.26279660
2	MP0010094_abnormal_chromosome_stability	4.20326900
3	MP0003111_abnormal_nucleus_morphology	4.00658437
4	MP0008057_abnormal_DNA_replication	3.75957441
5	MP0004957_abnormal_blastocyst_morpholog	3.62185250
6	MP0003077_abnormal_cell_cycle	3.49733115
7	MP0003123_paternal_imprinting	3.44315967
8	MP0009697_abnormal_copulation	2.67035051
9	MP0008058_abnormal_DNA_repair	2.66106362
10	MP0010030_abnormal_orbit_morphology	2.49923352
11	MP0003121_genomic_imprinting	2.48006331
12	MP0008932_abnormal_embryonic_tissue	2.42191203
13	MP0008007_abnormal_cellular_replicative	2.39973456
14	MP0001730_embryonic_growth_arrest	2.26847294
15	* MP0000350_abnormal_cell_proliferation	2.07684261
16	MP0008877_abnormal_DNA_methylation	2.04051075
17	MP0005380_embryogenesis_phenotype	1.95273965
18	MP0001672_abnormal_embryogenesis/_devel	1.95273965
19	MP0010352_gastrointestinal_tract_polyps	1.94468012
20	MP0009053_abnormal_anal_canal	1.88516565
21	MP0002085_abnormal_embryonic_tissue	1.84765186
22	MP0001697_abnormal_embryo_size	1.83058192
23	MP0004197_abnormal_fetal_growth/weight/	1.79937831
24	MP0002084_abnormal_developmental_patter	1.77984410
25	MP0010307_abnormal_tumor_latency	1.74705446
26	MP0003937_abnormal_limbs/digits/tail_de	1.74690884
27	MP0003984_embryonic_growth_retardation	1.74174437
28	MP0000537_abnormal_urethra_morphology	1.73872960
29	MP0002088_abnormal_embryonic_growth/wei	1.71519162
30	MP0001293_anophthalmia	1.71041092
31	MP0003567_abnormal_fetal_cardiomyocyte	1.69573851
32	MP0003122_maternal_imprinting	1.68269320
33	MP0002234_abnormal_pharynx_morphology	1.68240916
34	MP0002396_abnormal_hematopoietic_system	1.58094056
35	MP0005076_abnormal_cell_differentiation	1.57453929
36	MP0003890_abnormal_embryonic-extraembry	1.56766575
37	MP0002086_abnormal_extraembryonic_tissu	1.55743318
38	MP0002080_prenatal_lethality	1.55101681
39	MP0003119_abnormal_digestive_system	1.49506199
40	MP0005394_taste/olfaction_phenotype	1.41196849
41	MP0005499_abnormal_olfactory_system	1.41196849
42	MP0003385_abnormal_body_wall	1.40945463
43	MP0003705_abnormal_hypodermis_morpholog	1.38338224
44	MP0002938_white_spotting	1.33143823
45	MP0000428_abnormal_craniofacial_morphol	1.31177506
46	MP0003315_abnormal_perineum_morphology	1.26598658
47	MP0003786_premature_aging	1.24484550
48	MP0009672_abnormal_birth_weight	1.22969835
49	MP0003935_abnormal_craniofacial_develop	1.22806231
50	MP0003755_abnormal_palate_morphology	1.22136139
51	MP0004808_abnormal_hematopoietic_stem	1.21344783
52	MP0000049_abnormal_middle_ear	1.20742297
53	MP0002210_abnormal_sex_determination	1.20450979
54	MP0003115_abnormal_respiratory_system	1.19264867
55	MP0009703_decreased_birth_body	1.18385586
56	MP0002111_abnormal_tail_morphology	1.17204594
57	MP0003942_abnormal_urinary_system	1.17168550
58	MP0003136_yellow_coat_color	1.16448687
59	MP0001346_abnormal_lacrimal_gland	1.16364031
60	MP0000566_synostosis	1.12537185
61	MP0003718_maternal_effect	1.11662901
62	MP0006292_abnormal_olfactory_placode	1.10514956
63	MP0002249_abnormal_larynx_morphology	1.09907314
64	MP0005395_other_phenotype	1.09889823
65	MP0002932_abnormal_joint_morphology	1.08370646
66	MP0000432_abnormal_head_morphology	1.08320253
67	MP0000490_abnormal_crypts_of	1.07802853
68	MP0001286_abnormal_eye_development	1.06840301
69	MP0002092_abnormal_eye_morphology	1.06394140
70	* MP0000313_abnormal_cell_death	1.05747732
71	MP0001929_abnormal_gametogenesis	1.04796995
72	* MP0001145_abnormal_male_reproductive	1.04729266
73	MP0009250_abnormal_appendicular_skeleto	1.04323916
74	MP0006072_abnormal_retinal_apoptosis	1.04058315
75	MP0000631_abnormal_neuroendocrine_gland	1.02047116
76	MP0002282_abnormal_trachea_morphology	1.00939442
77	MP0002653_abnormal_ependyma_morphology	0.99234585
78	MP0003938_abnormal_ear_development	0.98167617
79	MP0000733_abnormal_muscle_development	0.95279450
80	MP0003699_abnormal_female_reproductive	0.94185815
81	MP0003941_abnormal_skin_development	0.93590302
82	MP0006054_spinal_hemorrhage	0.92781338
83	MP0001915_intracranial_hemorrhage	0.92300802
84	MP0002697_abnormal_eye_size	0.92164800
85	MP0002009_preneoplasia	0.91236230
86	MP0003861_abnormal_nervous_system	0.91040527
87	MP0002019_abnormal_tumor_incidence	0.89788085
88	MP0003787_abnormal_imprinting	0.89781127
89	* MP0000653_abnormal_sex_gland	0.89396859
90	MP0002114_abnormal_axial_skeleton	0.88966928
91	MP0002116_abnormal_craniofacial_bone	0.88934277
92	MP0000762_abnormal_tongue_morphology	0.86465338
93	MP0002233_abnormal_nose_morphology	0.85177456
94	MP0000647_abnormal_sebaceous_gland	0.84815289
95	MP0001661_extended_life_span	0.84702541
96	MP0004233_abnormal_muscle_weight	0.83797748
97	MP0003950_abnormal_plasma_membrane	0.83514489
98	MP0002751_abnormal_autonomic_nervous	0.83281471
99	MP0002160_abnormal_reproductive_system	0.81807639
100	MP0009278_abnormal_bone_marrow	0.81597904
101	MP0005391_vision/eye_phenotype	0.81549214
102	MP0002161_abnormal_fertility/fecundity	0.80597871
103	MP0004264_abnormal_extraembryonic_tissu	0.80440539
104	MP0002102_abnormal_ear_morphology	0.80009263
105	MP0008789_abnormal_olfactory_epithelium	0.78744444
106	MP0002109_abnormal_limb_morphology	0.78608165
107	MP0002925_abnormal_cardiovascular_devel	0.77769579
108	MP0004133_heterotaxia	0.76529219
109	MP0000534_abnormal_ureter_morphology	0.76514403
110	MP0006035_abnormal_mitochondrial_morpho	0.75268601
111	MP0000569_abnormal_digit_pigmentation	0.74628531
112	MP0001849_ear_inflammation	0.73172003
113	MP0000427_abnormal_hair_cycle	0.73078520
114	MP0005187_abnormal_penis_morphology	0.72571666
115	MP0005389_reproductive_system_phenotype	0.72297160
116	MP0001119_abnormal_female_reproductive	0.72093599
117	MP0010234_abnormal_vibrissa_follicle	0.71934212
118	MP0005248_abnormal_Harderian_gland	0.71548355
119	MP0001529_abnormal_vocalization	0.71331862
120	MP0000358_abnormal_cell_content/	0.70724990
121	MP0003698_abnormal_male_reproductive	0.69758733
122	MP0002163_abnormal_gland_morphology	0.67342067
123	MP0000516_abnormal_urinary_system	0.66266429
124	MP0005367_renal/urinary_system_phenotyp	0.66266429
125	MP0002081_perinatal_lethality	0.65516248
126	MP0000372_irregular_coat_pigmentation	0.65478963
127	MP0003943_abnormal_hepatobiliary_system	0.63149544
128	MP0001299_abnormal_eye_distance/	0.59149906

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Birth length less than 3rd percentile (HP:0003561)	3.94854476
2	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	3.78269961
3	Short 4th metacarpal (HP:0010044)	3.78269961
4	Patellar aplasia (HP:0006443)	3.40496710
5	Chromsome breakage (HP:0040012)	3.32058744
6	Colon cancer (HP:0003003)	3.28033363
7	Aplasia/Hypoplasia of the patella (HP:0006498)	3.25699910
8	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.23440654
9	Selective tooth agenesis (HP:0001592)	3.18168624
10	Impulsivity (HP:0100710)	3.13879824
11	Medulloblastoma (HP:0002885)	3.08920755
12	Breast hypoplasia (HP:0003187)	3.06340159
13	Abnormal number of incisors (HP:0011064)	2.94108602
14	Abnormality of the labia minora (HP:0012880)	2.86759811
15	Meckel diverticulum (HP:0002245)	2.85511119
16	Volvulus (HP:0002580)	2.79435119
17	Abnormality of the 4th metacarpal (HP:0010012)	2.79158990
18	Increased nuchal translucency (HP:0010880)	2.78175310
19	Ectopic kidney (HP:0000086)	2.78147244
20	Nephroblastoma (Wilms tumor) (HP:0002667)	2.76085306
21	Abnormality of the ileum (HP:0001549)	2.74108257
22	Facial hemangioma (HP:0000329)	2.67275130
23	Abnormal lung lobation (HP:0002101)	2.66067915
24	Embryonal renal neoplasm (HP:0011794)	2.64434596
25	Atresia of the external auditory canal (HP:0000413)	2.62122769
26	Proximal placement of thumb (HP:0009623)	2.59068214
27	Supernumerary spleens (HP:0009799)	2.56829012
28	Duodenal stenosis (HP:0100867)	2.55701779
29	Small intestinal stenosis (HP:0012848)	2.55701779
30	Absent radius (HP:0003974)	2.55530093
31	Ependymoma (HP:0002888)	2.54321998
32	Abnormality of chromosome stability (HP:0003220)	2.53949410
33	Deviation of the thumb (HP:0009603)	2.52361434
34	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.42540993
35	Aplasia involving forearm bones (HP:0009822)	2.40193865
36	Absent forearm bone (HP:0003953)	2.40193865
37	Abdominal situs inversus (HP:0003363)	2.39058507
38	Abnormality of abdominal situs (HP:0011620)	2.39058507
39	Renal duplication (HP:0000075)	2.34513322
40	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.34189995
41	Rhabdomyosarcoma (HP:0002859)	2.31815562
42	Abnormality of the preputium (HP:0100587)	2.30155348
43	Oligodactyly (hands) (HP:0001180)	2.25440399
44	Reticulocytopenia (HP:0001896)	2.23274458
45	Diastasis recti (HP:0001540)	2.18100794
46	Oligodactyly (HP:0012165)	2.17649133
47	Abnormality of the duodenum (HP:0002246)	2.15952338
48	High anterior hairline (HP:0009890)	2.14886792
49	Abnormality of the astrocytes (HP:0100707)	2.13356323
50	Astrocytoma (HP:0009592)	2.13356323
51	Short middle phalanx of the 5th finger (HP:0004220)	2.11484642
52	Clubbing of toes (HP:0100760)	2.10854868
53	Abnormality of the phalanges of the hallux (HP:0010057)	2.07117966
54	Short thumb (HP:0009778)	2.06707573
55	Duplication of thumb phalanx (HP:0009942)	2.06097566
56	Septo-optic dysplasia (HP:0100842)	2.04907844
57	Aplasia/hypoplasia of the humerus (HP:0006507)	2.03369261
58	Oral leukoplakia (HP:0002745)	2.01966659
59	Neoplasm of striated muscle (HP:0009728)	2.01837488
60	Glioma (HP:0009733)	2.01250618
61	Long eyelashes (HP:0000527)	1.99463901
62	Absent septum pellucidum (HP:0001331)	1.98937786
63	Neoplasm of the oral cavity (HP:0100649)	1.98641294
64	Rib fusion (HP:0000902)	1.98290149
65	Cortical dysplasia (HP:0002539)	1.98257745
66	Bifid tongue (HP:0010297)	1.97792516
67	Sloping forehead (HP:0000340)	1.97277538
68	Microvesicular hepatic steatosis (HP:0001414)	1.95377370
69	Choanal atresia (HP:0000453)	1.95050693
70	Carpal bone hypoplasia (HP:0001498)	1.94582603
71	Supernumerary bones of the axial skeleton (HP:0009144)	1.93708774
72	Duplicated collecting system (HP:0000081)	1.92551465
73	Broad thumb (HP:0011304)	1.92308201
74	Neoplasm of the pancreas (HP:0002894)	1.92254736
75	Supernumerary ribs (HP:0005815)	1.92240656
76	Myelodysplasia (HP:0002863)	1.91978565
77	Abnormality of the anterior horn cell (HP:0006802)	1.90779652
78	Degeneration of anterior horn cells (HP:0002398)	1.90779652
79	Bilateral microphthalmos (HP:0007633)	1.90756470
80	Abnormality of the septum pellucidum (HP:0007375)	1.88684585
81	Abnormality of the carotid arteries (HP:0005344)	1.88342252
82	Tracheoesophageal fistula (HP:0002575)	1.87132441
83	Short humerus (HP:0005792)	1.86932985
84	Hyperglycinemia (HP:0002154)	1.86217045
85	Shawl scrotum (HP:0000049)	1.85184255
86	Broad phalanges of the hand (HP:0009768)	1.84165178
87	Abnormality of cochlea (HP:0000375)	1.84023573
88	Horseshoe kidney (HP:0000085)	1.83006835
89	Triphalangeal thumb (HP:0001199)	1.82357101
90	Prominent nose (HP:0000448)	1.81429556
91	Short 5th finger (HP:0009237)	1.81288153
92	Overlapping toe (HP:0001845)	1.79786484
93	Microglossia (HP:0000171)	1.79548859
94	Microtia (HP:0008551)	1.79451035
95	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.79023178
96	Pelvic girdle muscle weakness (HP:0003749)	1.78551142
97	Abnormality of methionine metabolism (HP:0010901)	1.78128280
98	High pitched voice (HP:0001620)	1.77841626
99	Neoplasm of the colon (HP:0100273)	1.77592337
100	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.77017369
101	Facial cleft (HP:0002006)	1.76666933
102	Absent thumb (HP:0009777)	1.76300412
103	Abnormality of DNA repair (HP:0003254)	1.75018266
104	Megaloblastic anemia (HP:0001889)	1.74060402
105	Premature graying of hair (HP:0002216)	1.72527849
106	Hepatoblastoma (HP:0002884)	1.72181502
107	Preauricular skin tag (HP:0000384)	1.71877050
108	Skin tags (HP:0010609)	1.71874064
109	Malignant gastrointestinal tract tumors (HP:0006749)	1.71638230
110	Gastrointestinal carcinoma (HP:0002672)	1.71638230
111	Rough bone trabeculation (HP:0100670)	1.71128317
112	Abnormality of the renal collecting system (HP:0004742)	1.70807568
113	Preaxial hand polydactyly (HP:0001177)	1.70087769
114	Broad finger (HP:0001500)	1.69860299
115	Agnosia (HP:0010524)	1.69728199
116	Short tibia (HP:0005736)	1.69712797
117	Cafe-au-lait spot (HP:0000957)	1.69649442
118	Syringomyelia (HP:0003396)	1.69616542
119	Spinal cord lesions (HP:0100561)	1.69616542
120	Shallow orbits (HP:0000586)	1.69010722
121	Multiple enchondromatosis (HP:0005701)	1.68601837
122	Capillary hemangiomas (HP:0005306)	1.68253073
123	Skull defect (HP:0001362)	1.67860176
124	Partial agenesis of the corpus callosum (HP:0001338)	1.67786070
125	Esophageal atresia (HP:0002032)	1.66540171
126	Arteriovenous malformation (HP:0100026)	1.65826557
127	Increased serum pyruvate (HP:0003542)	1.65735289
128	Trigonocephaly (HP:0000243)	1.65685212
129	Abnormality of alanine metabolism (HP:0010916)	1.61840388
130	Hyperalaninemia (HP:0003348)	1.61840388
131	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.61840388
132	Hypoplastic pelvis (HP:0008839)	1.61812535
133	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.61797672
134	Abnormality of glycolysis (HP:0004366)	1.59953990
135	Bicornuate uterus (HP:0000813)	1.59615321
136	Gastrointestinal atresia (HP:0002589)	1.58452903
137	Cleft eyelid (HP:0000625)	1.56615688
138	Abnormality of the pons (HP:0007361)	1.56371657
139	Macrocytic anemia (HP:0001972)	1.55480841
140	Abnormality of serum amino acid levels (HP:0003112)	1.54893131
141	Premature ovarian failure (HP:0008209)	1.53152116
142	Hypoplasia of the pons (HP:0012110)	1.52097456
143	Intestinal atresia (HP:0011100)	1.51863805
144	Dandy-Walker malformation (HP:0001305)	1.51383303
145	Gonadotropin excess (HP:0000837)	1.51358086
146	Abnormality of chromosome segregation (HP:0002916)	1.50661622
147	Embryonal neoplasm (HP:0002898)	1.50091050

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	5.14108833
2	BUB1	4.04155122
3	WEE1	3.99760064
4	NEK2	3.39270160
5	PBK	2.80359967
6	TTK	2.72975107
7	SRPK1	2.70805455
8	MKNK1	2.45664257
9	PLK4	2.37267958
10	CDK12	2.36426051
11	BRSK2	2.31362181
12	EIF2AK1	2.26719847
13	NEK1	2.22681833
14	PLK1	2.20982530
15	ACVR1B	2.15553359
16	PLK3	1.90877552
17	NUAK1	1.90701080
18	VRK2	1.90671791
19	ATR	1.83505368
20	TSSK6	1.82866483
21	CDK7	1.82654441
22	AURKB	1.79919992
23	CHEK2	1.77892944
24	MKNK2	1.76068752
25	LATS1	1.74788584
26	DYRK3	1.63351539
27	CCNB1	1.60262332
28	RPS6KA4	1.55318956
29	BRSK1	1.53913887
30	CHEK1	1.49691208
31	PASK	1.49525368
32	CDK4	1.45241083
33	STK3	1.35361351
34	MAP3K10	1.34264331
35	MAP3K8	1.33942574
36	BRD4	1.30192198
37	LATS2	1.27964446
38	BMPR1B	1.25367266
39	TGFBR1	1.23864884
40	TRIM28	1.21796407
41	RPS6KB2	1.21474124
42	PAK4	1.19404443
43	STK10	1.17934537
44	TAF1	1.16627660
45	VRK1	1.15210942
46	NME1	1.14237633
47	MELK	1.14145112
48	AURKA	1.11340185
49	ATM	1.11333004
50	EEF2K	1.10686931
51	STK38L	1.08927330
52	STK4	1.08729151
53	CDK6	1.07547232
54	TESK2	1.06908921
55	* CDK2	1.05526007
56	EIF2AK3	1.02238831
57	TLK1	0.98710151
58	ICK	0.98120807
59	CDK1	0.89756572
60	MET	0.86250137
61	ZAK	0.83028413
62	STK39	0.80559995
63	EPHA2	0.78038453
64	SCYL2	0.78017015
65	MTOR	0.76793604
66	EIF2AK2	0.75524703
67	PNCK	0.74596086
68	WNK4	0.74209161
69	MAP3K9	0.72701054
70	FLT3	0.71868131
71	TESK1	0.70015672
72	ALK	0.68549147
73	PDK2	0.68351939
74	MST4	0.66922256
75	TNIK	0.66507793
76	CDK8	0.63626384
77	WNK3	0.63528524
78	NME2	0.60578795
79	CSNK2A2	0.59052277
80	MAP4K2	0.58137514
81	CSNK2A1	0.56676293
82	PAK2	0.56290760
83	INSRR	0.56131993
84	MAP3K4	0.55361724
85	FGFR1	0.55035388
86	PAK1	0.54847137
87	CSNK1E	0.51692310
88	MUSK	0.50236780
89	ERBB4	0.49665208
90	CAMK1D	0.48475087
91	CSNK1G2	0.48400088
92	PKN2	0.47704961
93	MAPKAPK5	0.47188048
94	PRKDC	0.47177273
95	AKT2	0.46783121
96	RAF1	0.45940391
97	PDK4	0.45507797
98	PDK3	0.45507797
99	BCR	0.44831990
100	CLK1	0.43527882
101	OXSR1	0.42771290
102	STK24	0.41728372
103	MAPK14	0.41082823
104	YES1	0.40890875
105	ERBB3	0.40125755
106	DDR2	0.39497777
107	CSNK1A1L	0.38460291
108	LRRK2	0.38222338
109	AKT3	0.36930415
110	CAMK1G	0.36702402
111	CSNK1G3	0.35673669
112	ARAF	0.35563094
113	CDK19	0.34456475
114	AKT1	0.34125362
115	CSNK1D	0.33765083
116	TAOK2	0.33016539
117	CDK3	0.32062241
118	GSK3B	0.32033290
119	CSNK1G1	0.31399903
120	DYRK2	0.30212053
121	PDGFRA	0.30106837
122	RPS6KA5	0.28523017
123	PLK2	0.28504096
124	CDK9	0.27937910
125	STK16	0.27576967
126	PTK6	0.26355361
127	PRKCI	0.26131928
128	KDR	0.25648795
129	TTN	0.24157923
130	MAPK1	0.24131643
131	BRAF	0.22015362
132	EPHB2	0.21815275

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	5.17751943
2	Mismatch repair_Homo sapiens_hsa03430	4.35465588
3	* Cell cycle_Homo sapiens_hsa04110	3.61820506
4	RNA transport_Homo sapiens_hsa03013	3.52613208
5	Spliceosome_Homo sapiens_hsa03040	3.51940208
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.51203778
7	Base excision repair_Homo sapiens_hsa03410	3.05818609
8	Homologous recombination_Homo sapiens_hsa03440	2.94780228
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.80869889
10	One carbon pool by folate_Homo sapiens_hsa00670	2.58121696
11	RNA polymerase_Homo sapiens_hsa03020	2.51494995
12	Fanconi anemia pathway_Homo sapiens_hsa03460	2.48743672
13	mRNA surveillance pathway_Homo sapiens_hsa03015	2.27162865
14	Pyrimidine metabolism_Homo sapiens_hsa00240	2.16671379
15	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.15425988
16	Ribosome_Homo sapiens_hsa03010	2.08141138
17	Non-homologous end-joining_Homo sapiens_hsa03450	2.04814455
18	RNA degradation_Homo sapiens_hsa03018	1.98298340
19	p53 signaling pathway_Homo sapiens_hsa04115	1.94784364
20	Proteasome_Homo sapiens_hsa03050	1.93952075
21	Basal transcription factors_Homo sapiens_hsa03022	1.83879081
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.64222183
23	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.57562657
24	Oocyte meiosis_Homo sapiens_hsa04114	1.56312585
25	Basal cell carcinoma_Homo sapiens_hsa05217	1.43734366
26	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.42959074
27	* Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.37596411
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28400848
29	MicroRNAs in cancer_Homo sapiens_hsa05206	1.27079076
30	Protein export_Homo sapiens_hsa03060	1.24464572
31	Pyruvate metabolism_Homo sapiens_hsa00620	1.22675255
32	Hippo signaling pathway_Homo sapiens_hsa04390	1.19038476
33	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.18133386
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18086342
35	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.17586726
36	Purine metabolism_Homo sapiens_hsa00230	1.16469429
37	* Viral carcinogenesis_Homo sapiens_hsa05203	1.15041333
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.10511414
39	Propanoate metabolism_Homo sapiens_hsa00640	1.10362866
40	* Epstein-Barr virus infection_Homo sapiens_hsa05169	1.09150330
41	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.05943414
42	HTLV-I infection_Homo sapiens_hsa05166	1.02876706
43	Steroid biosynthesis_Homo sapiens_hsa00100	1.02531748
44	Fatty acid elongation_Homo sapiens_hsa00062	1.02457037
45	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.02289132
46	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.99676115
47	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.97800627
48	Huntingtons disease_Homo sapiens_hsa05016	0.89309249
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.87835508
50	Parkinsons disease_Homo sapiens_hsa05012	0.87673744
51	* Small cell lung cancer_Homo sapiens_hsa05222	0.87571512
52	Sulfur relay system_Homo sapiens_hsa04122	0.87492102
53	* Herpes simplex infection_Homo sapiens_hsa05168	0.81003264
54	Adherens junction_Homo sapiens_hsa04520	0.79724115
55	Oxidative phosphorylation_Homo sapiens_hsa00190	0.79478402
56	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.79069793
57	Thyroid cancer_Homo sapiens_hsa05216	0.78421576
58	Colorectal cancer_Homo sapiens_hsa05210	0.76163124
59	Alcoholism_Homo sapiens_hsa05034	0.75351075
60	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.71812176
61	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.71596893
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66794683
63	Antigen processing and presentation_Homo sapiens_hsa04612	0.66375771
64	Wnt signaling pathway_Homo sapiens_hsa04310	0.66279154
65	Selenocompound metabolism_Homo sapiens_hsa00450	0.63922753
66	Notch signaling pathway_Homo sapiens_hsa04330	0.61886310
67	Lysine degradation_Homo sapiens_hsa00310	0.61208920
68	Prostate cancer_Homo sapiens_hsa05215	0.59745882
69	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.59059385
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.59034448
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.58737120
72	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.57916848
73	* Pathways in cancer_Homo sapiens_hsa05200	0.52747309
74	Metabolic pathways_Homo sapiens_hsa01100	0.52679464
75	mTOR signaling pathway_Homo sapiens_hsa04150	0.50832946
76	Pentose phosphate pathway_Homo sapiens_hsa00030	0.50326556
77	Bladder cancer_Homo sapiens_hsa05219	0.50257252
78	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.49486292
79	Proteoglycans in cancer_Homo sapiens_hsa05205	0.47310314
80	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.45208383
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.45011241
82	Viral myocarditis_Homo sapiens_hsa05416	0.43602413
83	Hepatitis B_Homo sapiens_hsa05161	0.42647916
84	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.42325540
85	Endometrial cancer_Homo sapiens_hsa05213	0.41278494
86	Butanoate metabolism_Homo sapiens_hsa00650	0.40829521
87	Tight junction_Homo sapiens_hsa04530	0.40316358
88	Arginine biosynthesis_Homo sapiens_hsa00220	0.39462740
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38036085
90	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.37799832
91	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.37739723
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.37413630
93	Non-small cell lung cancer_Homo sapiens_hsa05223	0.37310676
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36856208
95	Alzheimers disease_Homo sapiens_hsa05010	0.36163131
96	Legionellosis_Homo sapiens_hsa05134	0.36063564
97	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.35999093
98	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.35700054
99	Caffeine metabolism_Homo sapiens_hsa00232	0.35308563
100	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.35156932
101	Melanoma_Homo sapiens_hsa05218	0.33121115
102	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32002904
103	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.30820279
104	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29155533
105	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.28668822
106	Nitrogen metabolism_Homo sapiens_hsa00910	0.28278350
107	Apoptosis_Homo sapiens_hsa04210	0.27578964
108	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.27189731
109	Renin-angiotensin system_Homo sapiens_hsa04614	0.26392929
110	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.26373550
111	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.26091742
112	Folate biosynthesis_Homo sapiens_hsa00790	0.25983501
113	Pancreatic cancer_Homo sapiens_hsa05212	0.25482791
114	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.24556111
115	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.24456945
116	Phototransduction_Homo sapiens_hsa04744	0.23462194
117	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.22658161
118	* FoxO signaling pathway_Homo sapiens_hsa04068	0.22090519
119	Olfactory transduction_Homo sapiens_hsa04740	0.21821595
120	Carbon metabolism_Homo sapiens_hsa01200	0.19865323
121	Peroxisome_Homo sapiens_hsa04146	0.19817490
122	Glutathione metabolism_Homo sapiens_hsa00480	0.19675371
123	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.19637508
124	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.19501332
125	Sulfur metabolism_Homo sapiens_hsa00920	0.19439851
126	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.17514187
127	Shigellosis_Homo sapiens_hsa05131	0.16909037
128	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.16169515
129	Focal adhesion_Homo sapiens_hsa04510	0.15065938
130	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.13405640
131	Tryptophan metabolism_Homo sapiens_hsa00380	0.13156883
132	Renal cell carcinoma_Homo sapiens_hsa05211	0.12295036
133	AMPK signaling pathway_Homo sapiens_hsa04152	0.10881034
134	Glioma_Homo sapiens_hsa05214	0.10835365
135	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.10712508
136	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.09408702
137	Measles_Homo sapiens_hsa05162	0.08922874
138	ECM-receptor interaction_Homo sapiens_hsa04512	0.07965680
139	Melanogenesis_Homo sapiens_hsa04916	0.07664483
140	Influenza A_Homo sapiens_hsa05164	0.07582980
141	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.06203650
142	Acute myeloid leukemia_Homo sapiens_hsa05221	0.03827926
143	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.02638479

SKP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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