SLA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.02967244
2ribosomal small subunit assembly (GO:0000028)6.89083644
3viral transcription (GO:0019083)6.65572736
4translational termination (GO:0006415)6.38099493
5ribosomal small subunit biogenesis (GO:0042274)5.66904366
6regulation of gamma-delta T cell differentiation (GO:0045586)5.46519876
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.43656775
8cotranslational protein targeting to membrane (GO:0006613)5.35116847
9translational elongation (GO:0006414)5.32227556
10protein targeting to ER (GO:0045047)5.31574013
11regulation of gamma-delta T cell activation (GO:0046643)5.09831882
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.05531971
13neutrophil activation involved in immune response (GO:0002283)5.01628429
14protein localization to endoplasmic reticulum (GO:0070972)5.01415155
15viral life cycle (GO:0019058)4.96867752
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.90619369
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.85878380
18cellular protein complex disassembly (GO:0043624)4.85583977
19maturation of SSU-rRNA (GO:0030490)4.85260456
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.84999087
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.84999087
22thrombin receptor signaling pathway (GO:0070493)4.64919982
23ribosomal large subunit biogenesis (GO:0042273)4.57828079
24negative regulation of erythrocyte differentiation (GO:0045647)4.49671061
25translational initiation (GO:0006413)4.45520045
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.39145725
27DNA deamination (GO:0045006)4.38108241
28protein complex disassembly (GO:0043241)4.25714224
29negative T cell selection (GO:0043383)4.12809532
30macromolecular complex disassembly (GO:0032984)4.01117128
31interferon-gamma production (GO:0032609)3.99455857
32antigen processing and presentation of endogenous antigen (GO:0019883)3.95655303
33Arp2/3 complex-mediated actin nucleation (GO:0034314)3.93268787
34neutrophil activation (GO:0042119)3.89578670
35protein neddylation (GO:0045116)3.82325591
36regulation of respiratory burst (GO:0060263)3.82189791
37Peyers patch development (GO:0048541)3.77620232
38mucosal-associated lymphoid tissue development (GO:0048537)3.77620232
39negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.76221753
40tolerance induction (GO:0002507)3.72889573
41positive T cell selection (GO:0043368)3.69587182
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.67882544
43cytidine deamination (GO:0009972)3.64284542
44cytidine metabolic process (GO:0046087)3.64284542
45cytidine catabolic process (GO:0006216)3.64284542
46positive regulation of mast cell activation (GO:0033005)3.64023408
47negative thymic T cell selection (GO:0045060)3.61528217
48purinergic nucleotide receptor signaling pathway (GO:0035590)3.60182635
49positive thymic T cell selection (GO:0045059)3.59840084
50leukocyte degranulation (GO:0043299)3.59791614
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.59633372
52activated T cell proliferation (GO:0050798)3.57464349
53nuclear-transcribed mRNA catabolic process (GO:0000956)3.55638611
54protein targeting to membrane (GO:0006612)3.53495734
55negative regulation of T-helper cell differentiation (GO:0045623)3.51844454
56negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.51844454
57regulation of alpha-beta T cell proliferation (GO:0046640)3.50393341
58positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50083881
59T cell homeostasis (GO:0043029)3.49791651
60positive regulation of alpha-beta T cell proliferation (GO:0046641)3.48146645
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.46950324
62regulation of platelet aggregation (GO:0090330)3.43665226
63mRNA catabolic process (GO:0006402)3.43465737
64granulocyte activation (GO:0036230)3.43308555
65mast cell activation (GO:0045576)3.42847285
66negative regulation of T cell mediated immunity (GO:0002710)3.41955007
67proteasome assembly (GO:0043248)3.39955315
68leukocyte migration involved in inflammatory response (GO:0002523)3.39140184
69G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.37830775
70positive regulation of isotype switching (GO:0045830)3.31782048
71T cell receptor signaling pathway (GO:0050852)3.30866867
72positive regulation of B cell differentiation (GO:0045579)3.30186662
73ribonucleoprotein complex biogenesis (GO:0022613)3.30012877
74negative regulation of T cell apoptotic process (GO:0070233)3.27836503
75regulation of regulatory T cell differentiation (GO:0045589)3.25581475
76pyrimidine ribonucleoside catabolic process (GO:0046133)3.24171870
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23363106
78regulation of B cell differentiation (GO:0045577)3.22288141
79leukocyte aggregation (GO:0070486)3.22080249
80positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.21696506
81positive regulation of natural killer cell mediated immunity (GO:0002717)3.21696506
82positive regulation of DNA recombination (GO:0045911)3.20419345
83positive regulation of tolerance induction (GO:0002645)3.19690437
84RNA catabolic process (GO:0006401)3.19509018
85B cell receptor signaling pathway (GO:0050853)3.17341433
86positive regulation of immunoglobulin mediated immune response (GO:0002891)3.16384954
87positive regulation of B cell mediated immunity (GO:0002714)3.16384954
88negative regulation of thymocyte apoptotic process (GO:0070244)3.16355315
89negative regulation of lymphocyte mediated immunity (GO:0002707)3.15049276
90megakaryocyte development (GO:0035855)3.14988451
91cellular response to interleukin-15 (GO:0071350)3.14429932
92T cell migration (GO:0072678)3.12905365
93regulation of memory T cell differentiation (GO:0043380)3.12599102
94translation (GO:0006412)3.11774227
95regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.11044473
96regulation of natural killer cell mediated immunity (GO:0002715)3.11044473
97positive regulation of granulocyte differentiation (GO:0030854)3.09335189
98myeloid cell activation involved in immune response (GO:0002275)3.07512813
99regulation of isotype switching to IgG isotypes (GO:0048302)3.07287875
100T cell selection (GO:0045058)3.05108781
101dendritic cell chemotaxis (GO:0002407)3.04641099
102positive regulation of macrophage differentiation (GO:0045651)3.04475985
103thymic T cell selection (GO:0045061)3.03638380
104regulation of mast cell activation (GO:0033003)3.02753906
105cellular extravasation (GO:0045123)3.00681301
106positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.99308564
107antigen processing and presentation via MHC class Ib (GO:0002475)2.97534595
108T cell differentiation (GO:0030217)2.97438834
109response to interleukin-15 (GO:0070672)2.96543253
110regulation of B cell receptor signaling pathway (GO:0050855)2.96115292
111mast cell degranulation (GO:0043303)2.95167437
112mast cell activation involved in immune response (GO:0002279)2.95167437
113* antigen receptor-mediated signaling pathway (GO:0050851)2.93858257
114regulation of platelet activation (GO:0010543)2.93314941
115immunoglobulin mediated immune response (GO:0016064)2.88480115
116regulation of T cell receptor signaling pathway (GO:0050856)2.88189578
117pyrimidine nucleoside catabolic process (GO:0046135)2.86603946
118regulation of granulocyte differentiation (GO:0030852)2.83454752
119negative regulation of cell killing (GO:0031342)2.82764205
120negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.82764205
121regulation of leukocyte mediated cytotoxicity (GO:0001910)2.82701957
122respiratory chain complex IV assembly (GO:0008535)2.82499331
123peptidyl-arginine omega-N-methylation (GO:0035247)2.82271654
124actin nucleation (GO:0045010)2.82059394
125dendritic cell migration (GO:0036336)2.81719082
126modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80511125
127positive regulation by organism of defense response of other organism involved in symbiotic interact2.80511125
128modulation by symbiont of host immune response (GO:0052553)2.80511125
129positive regulation by symbiont of host defense response (GO:0052509)2.80511125
130modulation by symbiont of host defense response (GO:0052031)2.80511125
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80511125
132telomere maintenance via semi-conservative replication (GO:0032201)2.80270905
133mature B cell differentiation (GO:0002335)2.78319497
134ncRNA 3-end processing (GO:0043628)2.78284644
135regulation of T cell mediated cytotoxicity (GO:0001914)2.77703022
136positive regulation of T cell mediated cytotoxicity (GO:0001916)2.76657088
137regulation of B cell mediated immunity (GO:0002712)2.74841795
138lymphoid progenitor cell differentiation (GO:0002320)2.74722715
139negative regulation of myeloid cell apoptotic process (GO:0033033)2.73569171
140positive regulation of interleukin-4 production (GO:0032753)2.73387654
141purinergic receptor signaling pathway (GO:0035587)2.73241635
142negative regulation of alpha-beta T cell activation (GO:0046636)2.73009092
143negative regulation of leukocyte mediated immunity (GO:0002704)2.72745251
144regulation of cell killing (GO:0031341)2.72548774
145regulation of interleukin-2 biosynthetic process (GO:0045076)2.72542288
146lymphocyte costimulation (GO:0031294)2.72033728
147regulation of tolerance induction (GO:0002643)2.71463587
148DNA ligation (GO:0006266)2.70966022
149T cell costimulation (GO:0031295)2.70574894
150rRNA processing (GO:0006364)2.69084524
151regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.68169342
152platelet dense granule organization (GO:0060155)2.66894543
153rRNA metabolic process (GO:0016072)2.61445816
154deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59936555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.12778987
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43687158
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.30881144
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.26391805
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.13105828
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.12194523
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.04828853
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.04724742
9SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.00078988
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.80571913
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.75298931
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74637253
13SCL_19346495_ChIP-Seq_HPC-7_Human2.70165738
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.69471167
15* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.62014839
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.61825947
17FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.59436559
18* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55219492
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53528758
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41747781
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.39534980
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.38682374
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25693865
24SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.19956677
25MYC_22102868_ChIP-Seq_BL_Human2.18028359
26MYB_26560356_Chip-Seq_TH2_Human2.16996228
27* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15852056
28VDR_23849224_ChIP-Seq_CD4+_Human2.15484925
29VDR_21846776_ChIP-Seq_THP-1_Human2.14151624
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.12130792
31FOXP3_21729870_ChIP-Seq_TREG_Human2.10612075
32ETS1_20019798_ChIP-Seq_JURKAT_Human2.09092433
33GATA3_26560356_Chip-Seq_TH2_Human2.08898109
34* SPI1_23547873_ChIP-Seq_NB4_Human2.08382910
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05480744
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04777455
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03337538
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03039153
39MAF_26560356_Chip-Seq_TH1_Human2.00334722
40ERG_20887958_ChIP-Seq_HPC-7_Mouse1.99846607
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99310631
42XRN2_22483619_ChIP-Seq_HELA_Human1.98589167
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.94617747
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93445434
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.92614897
46GATA1_22025678_ChIP-Seq_K562_Human1.90971727
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89223364
48MYB_26560356_Chip-Seq_TH1_Human1.87950203
49UTX_26944678_Chip-Seq_JUKART_Human1.82634125
50RUNX_20019798_ChIP-Seq_JUKART_Human1.80948436
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.79845431
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72848108
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71560165
54GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.71125295
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66324636
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64539099
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.64383950
58DCP1A_22483619_ChIP-Seq_HELA_Human1.63657006
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61842215
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61801975
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.57868066
62ELK1_19687146_ChIP-ChIP_HELA_Human1.57811413
63MAF_26560356_Chip-Seq_TH2_Human1.57368095
64GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.56537711
65VDR_24763502_ChIP-Seq_THP-1_Human1.54832337
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52210950
67TTF2_22483619_ChIP-Seq_HELA_Human1.52010303
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49919248
69BP1_19119308_ChIP-ChIP_Hs578T_Human1.49425876
70GATA1_19941826_ChIP-Seq_K562_Human1.47475495
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.45929648
72CIITA_25753668_ChIP-Seq_RAJI_Human1.42239026
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.41561686
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41403087
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38085426
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38072986
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.37437355
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35368574
79LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35040895
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33691080
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33305307
82GABP_19822575_ChIP-Seq_HepG2_Human1.32790549
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.27571301
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27361274
85SRF_21415370_ChIP-Seq_HL-1_Mouse1.27073971
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26508083
87* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24726734
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23883674
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23673858
90* TCF7_22412390_ChIP-Seq_EML_Mouse1.22996184
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21442909
92NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19096848
93NELFA_20434984_ChIP-Seq_ESCs_Mouse1.17219483
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15666734
95GATA2_19941826_ChIP-Seq_K562_Human1.15559257
96IRF1_19129219_ChIP-ChIP_H3396_Human1.13386719
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13084088
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.12608060
99BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11486031
100GATA3_26560356_Chip-Seq_TH1_Human1.10129903
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10094022
102PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09537130
103TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08878579
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08259780
105FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07455186
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07394702
107E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05751283
108E2F1_21310950_ChIP-Seq_MCF-7_Human1.04183952
109GATA3_27048872_Chip-Seq_THYMUS_Human1.03497824
110GATA2_21666600_ChIP-Seq_HMVEC_Human1.02767098
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01518286
112SMRT_27268052_Chip-Seq_Bcells_Human0.99416682
113NANOG_20526341_ChIP-Seq_ESCs_Human0.99395255
114GATA3_21878914_ChIP-Seq_MCF-7_Human0.97642282
115EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96203824
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95590227
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94786479
118VDR_22108803_ChIP-Seq_LS180_Human0.94647888
119MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94621291
120VDR_24787735_ChIP-Seq_THP-1_Human0.93499414
121MYC_18940864_ChIP-ChIP_HL60_Human0.92908250
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92378321
123BCL6_27268052_Chip-Seq_Bcells_Human0.92347411
124RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92007782
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91692087
126SPI1_23127762_ChIP-Seq_K562_Human0.91620290
127HTT_18923047_ChIP-ChIP_STHdh_Human0.91440109
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91172354
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.90041089
130* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90000042
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89867239
132PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89553579
133SPI1_20517297_ChIP-Seq_HL60_Human0.89315711
134EGR1_19374776_ChIP-ChIP_THP-1_Human0.89308343
135SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89191378
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89176555
137P300_27268052_Chip-Seq_Bcells_Human0.87863251
138AR_20517297_ChIP-Seq_VCAP_Human0.87548284
139SALL4_22934838_ChIP-ChIP_CD34+_Human0.84712852
140EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84362390
141CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84062062
142FOXA1_25329375_ChIP-Seq_VCAP_Human0.83700351
143FOXA1_27270436_Chip-Seq_PROSTATE_Human0.83700351
144ETS1_22383799_ChIP-Seq_G1ME_Mouse0.83376992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.29542840
2MP0003763_abnormal_thymus_physiology4.05801372
3MP0005671_abnormal_response_to3.78628645
4MP0000685_abnormal_immune_system3.25653119
5MP0003724_increased_susceptibility_to3.11451613
6MP0001835_abnormal_antigen_presentation3.07001852
7MP0009785_altered_susceptibility_to2.89808565
8MP0009333_abnormal_splenocyte_physiolog2.70501175
9MP0002398_abnormal_bone_marrow2.56052157
10MP0002166_altered_tumor_susceptibility2.55883298
11MP0001800_abnormal_humoral_immune2.54059876
12MP0002396_abnormal_hematopoietic_system2.51242028
13MP0002420_abnormal_adaptive_immunity2.45095397
14MP0005174_abnormal_tail_pigmentation2.44848867
15MP0000703_abnormal_thymus_morphology2.44135358
16MP0001819_abnormal_immune_cell2.43474477
17MP0002723_abnormal_immune_serum2.38891999
18MP0005000_abnormal_immune_tolerance2.35161893
19MP0005025_abnormal_response_to2.33279241
20MP0010155_abnormal_intestine_physiology2.24876401
21MP0002452_abnormal_antigen_presenting2.22185693
22MP0000716_abnormal_immune_system2.15191727
23MP0002722_abnormal_immune_system2.11945140
24MP0002006_tumorigenesis2.06269797
25MP0003866_abnormal_defecation2.04060719
26MP0000689_abnormal_spleen_morphology2.03674401
27MP0004808_abnormal_hematopoietic_stem2.02711356
28MP0001790_abnormal_immune_system2.01621785
29MP0005387_immune_system_phenotype2.01621785
30MP0005075_abnormal_melanosome_morpholog1.98577650
31MP0002148_abnormal_hypersensitivity_rea1.97963877
32MP0008004_abnormal_stomach_pH1.93389878
33MP0000490_abnormal_crypts_of1.93144378
34MP0003693_abnormal_embryo_hatching1.90103443
35MP0003436_decreased_susceptibility_to1.89117844
36MP0002429_abnormal_blood_cell1.87936556
37MP0010094_abnormal_chromosome_stability1.86627218
38MP0002095_abnormal_skin_pigmentation1.84724333
39MP0002405_respiratory_system_inflammati1.80743135
40MP0004381_abnormal_hair_follicle1.78571955
41MP0005464_abnormal_platelet_physiology1.70407615
42MP0002419_abnormal_innate_immunity1.62400057
43MP0005397_hematopoietic_system_phenotyp1.61849806
44MP0001545_abnormal_hematopoietic_system1.61849806
45MP0001853_heart_inflammation1.60505488
46MP0001873_stomach_inflammation1.60352579
47MP0005409_darkened_coat_color1.52810135
48MP0002132_abnormal_respiratory_system1.50631443
49MP0005084_abnormal_gallbladder_morpholo1.49786295
50MP0008058_abnormal_DNA_repair1.49594014
51MP0003303_peritoneal_inflammation1.47745623
52MP0002933_joint_inflammation1.44528074
53MP0006082_CNS_inflammation1.42200963
54MP0001845_abnormal_inflammatory_respons1.41001898
55MP0000465_gastrointestinal_hemorrhage1.40305863
56MP0003300_gastrointestinal_ulcer1.38937676
57MP0008007_abnormal_cellular_replicative1.37210285
58MP0004947_skin_inflammation1.34151845
59MP0004957_abnormal_blastocyst_morpholog1.33093637
60MP0003077_abnormal_cell_cycle1.32237573
61MP0008872_abnormal_physiological_respon1.29182455
62MP0000015_abnormal_ear_pigmentation1.24349289
63MP0003806_abnormal_nucleotide_metabolis1.22389709
64MP0001986_abnormal_taste_sensitivity1.21283533
65MP0002019_abnormal_tumor_incidence1.18718742
66MP0008877_abnormal_DNA_methylation1.08863845
67MP0008469_abnormal_protein_level1.07425568
68MP0000858_altered_metastatic_potential1.07158334
69MP0006292_abnormal_olfactory_placode1.06068579
70MP0008057_abnormal_DNA_replication1.06043878
71MP0002009_preneoplasia1.05231171
72MP0001663_abnormal_digestive_system1.02614248
73MP0003638_abnormal_response/metabolism_1.01976166
74MP0002163_abnormal_gland_morphology0.99389229
75MP0004142_abnormal_muscle_tone0.99181115
76MP0000230_abnormal_systemic_arterial0.98688077
77MP0003172_abnormal_lysosome_physiology0.97224995
78MP0005083_abnormal_biliary_tract0.95661810
79MP0003943_abnormal_hepatobiliary_system0.94175727
80MP0009278_abnormal_bone_marrow0.94164461
81MP0005646_abnormal_pituitary_gland0.92860211
82MP0001188_hyperpigmentation0.92099151
83MP0003448_altered_tumor_morphology0.91607095
84MP0008932_abnormal_embryonic_tissue0.91398682
85MP0004130_abnormal_muscle_cell0.90781391
86MP0005310_abnormal_salivary_gland0.88908327
87MP0004510_myositis0.87544693
88MP0005410_abnormal_fertilization0.87285543
89MP0000313_abnormal_cell_death0.86825778
90MP0002102_abnormal_ear_morphology0.85161878
91MP0006036_abnormal_mitochondrial_physio0.84305078
92MP0001968_abnormal_touch/_nociception0.84124917
93MP0005167_abnormal_blood-brain_barrier0.83969742
94MP0003828_pulmonary_edema0.83612269
95MP0002693_abnormal_pancreas_physiology0.82718820
96MP0002736_abnormal_nociception_after0.82668957
97MP0003787_abnormal_imprinting0.81555417
98MP0003111_abnormal_nucleus_morphology0.79451718
99MP0009765_abnormal_xenobiotic_induced0.78556460
100MP0003656_abnormal_erythrocyte_physiolo0.76440725
101MP0003786_premature_aging0.75894749
102MP0009764_decreased_sensitivity_to0.75730522
103MP0001533_abnormal_skeleton_physiology0.73005110
104MP0000249_abnormal_blood_vessel0.70816318
105MP0002254_reproductive_system_inflammat0.70590548
106MP0001765_abnormal_ion_homeostasis0.69661481
107MP0002277_abnormal_respiratory_mucosa0.69206716
108MP0009642_abnormal_blood_homeostasis0.68270002
109MP0000477_abnormal_intestine_morphology0.67934381
110MP0008873_increased_physiological_sensi0.67811428
111MP0009763_increased_sensitivity_to0.65936460
112MP0000372_irregular_coat_pigmentation0.65277853
113MP0006035_abnormal_mitochondrial_morpho0.65034443
114MP0002733_abnormal_thermal_nociception0.64644812
115MP0003183_abnormal_peptide_metabolism0.63110897
116MP0005535_abnormal_body_temperature0.62791448
117MP0008874_decreased_physiological_sensi0.61588531
118MP0001879_abnormal_lymphatic_vessel0.60494167
119MP0005381_digestive/alimentary_phenotyp0.58736315
120MP0003252_abnormal_bile_duct0.58567665
121MP0001851_eye_inflammation0.58560587
122MP0004883_abnormal_blood_vessel0.57415352
123MP0002138_abnormal_hepatobiliary_system0.56014584
124MP0001119_abnormal_female_reproductive0.54924361
125MP0001919_abnormal_reproductive_system0.54765130
126MP0002998_abnormal_bone_remodeling0.53187085
127MP0000350_abnormal_cell_proliferation0.52147264
128MP0001243_abnormal_dermal_layer0.50735438
129MP0003868_abnormal_feces_composition0.50288870
130MP0004147_increased_porphyrin_level0.47678667
131MP0003959_abnormal_lean_body0.47550954
132MP0000343_altered_response_to0.47317436

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.10605854
2Menorrhagia (HP:0000132)5.01947790
3T lymphocytopenia (HP:0005403)4.87477298
4Increased mean platelet volume (HP:0011877)4.80219563
5Abnormality of T cell number (HP:0011839)4.59459076
6Gingival bleeding (HP:0000225)4.40433934
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.24868575
8Decreased activity of mitochondrial respiratory chain (HP:0008972)4.24868575
9Abnormality of cells of the erythroid lineage (HP:0012130)4.19548180
10Abnormal number of erythroid precursors (HP:0012131)4.07097600
11Chronic otitis media (HP:0000389)3.98516052
12IgM deficiency (HP:0002850)3.90543086
13Abnormality of T cells (HP:0002843)3.88735851
14Elevated erythrocyte sedimentation rate (HP:0003565)3.86883240
15Severe combined immunodeficiency (HP:0004430)3.73879299
16Thrombocytosis (HP:0001894)3.72330470
17Macrocytic anemia (HP:0001972)3.69819292
18Panhypogammaglobulinemia (HP:0003139)3.57751461
19Stomatitis (HP:0010280)3.56048728
20Myositis (HP:0100614)3.52154868
21B lymphocytopenia (HP:0010976)3.51985803
22Abnormality of B cell number (HP:0010975)3.51985803
23Pallor (HP:0000980)3.45329773
24Increased intramyocellular lipid droplets (HP:0012240)3.44678622
25Thyroiditis (HP:0100646)3.40445782
26Recurrent bronchitis (HP:0002837)3.35710546
27Aplastic anemia (HP:0001915)3.32518721
28Combined immunodeficiency (HP:0005387)3.29380880
29IgG deficiency (HP:0004315)3.29212171
30Prolonged bleeding time (HP:0003010)3.18175777
31Autoimmune hemolytic anemia (HP:0001890)3.17781840
32Abnormality of macrophages (HP:0004311)3.11374617
33Ragged-red muscle fibers (HP:0003200)3.09263613
34Recurrent viral infections (HP:0004429)3.06067852
353-Methylglutaconic aciduria (HP:0003535)3.02323636
36Abnormal hemoglobin (HP:0011902)2.96305218
37Recurrent fungal infections (HP:0002841)2.92554090
38Abnormality of T cell physiology (HP:0011840)2.91716265
39Increased muscle lipid content (HP:0009058)2.87298241
40Hyperlipoproteinemia (HP:0010980)2.82782776
41Nasal polyposis (HP:0100582)2.82427084
42Abnormality of eosinophils (HP:0001879)2.81394238
43Obstructive lung disease (HP:0006536)2.76356332
44Chronic obstructive pulmonary disease (HP:0006510)2.76356332
45Hepatocellular necrosis (HP:0001404)2.76027999
46Joint swelling (HP:0001386)2.72499512
47Meningitis (HP:0001287)2.70240430
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.69561017
49Petechiae (HP:0000967)2.69346943
50Autoimmune thrombocytopenia (HP:0001973)2.67155411
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66526322
52Recurrent abscess formation (HP:0002722)2.64195891
53Abnormality of the nasal mucosa (HP:0000433)2.63191144
54Muscle fiber atrophy (HP:0100295)2.59720001
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.58406368
56Vasculitis (HP:0002633)2.58244213
57Eosinophilia (HP:0001880)2.58153118
58Exertional dyspnea (HP:0002875)2.56755740
59Type 2 muscle fiber atrophy (HP:0003554)2.54649278
60Increased hepatocellular lipid droplets (HP:0006565)2.53350458
61Hypoproteinemia (HP:0003075)2.50527853
62Abnormality of the prostate (HP:0008775)2.48320785
63Gastrointestinal infarctions (HP:0005244)2.48265457
64Acute lymphatic leukemia (HP:0006721)2.46514507
65Chest pain (HP:0100749)2.45119907
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.44108551
67Hypoplasia of the thymus (HP:0000778)2.43336568
68Encephalitis (HP:0002383)2.43236914
69Granulocytopenia (HP:0001913)2.42825379
70Lymphopenia (HP:0001888)2.41118101
71Chronic mucocutaneous candidiasis (HP:0002728)2.41106614
72Recurrent cutaneous fungal infections (HP:0011370)2.41106614
73Eczematoid dermatitis (HP:0000976)2.39603975
74Optic neuritis (HP:0100653)2.38028195
75Retrobulbar optic neuritis (HP:0100654)2.38028195
76Episodic fever (HP:0001954)2.37055595
77Lymphoma (HP:0002665)2.36594902
78Pustule (HP:0200039)2.36197010
79Epistaxis (HP:0000421)2.35770130
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.34721239
81Dyschromatopsia (HP:0007641)2.32625222
82Abnormality of the heme biosynthetic pathway (HP:0010472)2.32592198
83Aplasia/Hypoplasia of the thymus (HP:0010515)2.29422180
84Colon cancer (HP:0003003)2.27844709
85Leukocytosis (HP:0001974)2.27715676
86Pancytopenia (HP:0001876)2.27689127
87Reduced antithrombin III activity (HP:0001976)2.27631486
88Arterial thrombosis (HP:0004420)2.26826957
89Recurrent skin infections (HP:0001581)2.26683550
90Hypochromic anemia (HP:0001931)2.25242442
91Spontaneous hematomas (HP:0007420)2.20609138
92Poikilocytosis (HP:0004447)2.19266330
93Abnormal pupillary function (HP:0007686)2.16769462
94Keratoconjunctivitis sicca (HP:0001097)2.16723454
95Hypergammaglobulinemia (HP:0010702)2.15936477
96Absent rod-and cone-mediated responses on ERG (HP:0007688)2.15584612
97Hepatic necrosis (HP:0002605)2.14857536
98Renal Fanconi syndrome (HP:0001994)2.14567837
99Orchitis (HP:0100796)2.14434533
100Basal cell carcinoma (HP:0002671)2.12395309
101Abnormal platelet function (HP:0011869)2.12237808
102Impaired platelet aggregation (HP:0003540)2.12237808
103Keratoconjunctivitis (HP:0001096)2.12060423
104Increased IgM level (HP:0003496)2.10311726
105Abnormality of iron homeostasis (HP:0011031)2.09844567
106Pulmonary infiltrates (HP:0002113)2.09563993
107Respiratory difficulties (HP:0002880)2.09106078
108Congenital, generalized hypertrichosis (HP:0004540)2.06795780
109Anorexia (HP:0002039)2.06787807
110Amaurosis fugax (HP:0100576)2.05586948
111Myelodysplasia (HP:0002863)2.03278252
112Microcytic anemia (HP:0001935)2.02638547
113Lipid accumulation in hepatocytes (HP:0006561)2.02427755
114Acute hepatic failure (HP:0006554)2.02412605
115Hemoptysis (HP:0002105)2.01978849
116Absent thumb (HP:0009777)2.01513165
117Abnormality of transition element cation homeostasis (HP:0011030)2.00737395
118Mediastinal lymphadenopathy (HP:0100721)2.00285461
119Gastrointestinal inflammation (HP:0004386)1.99832666
120Inflammation of the large intestine (HP:0002037)1.98344851
121Oral leukoplakia (HP:0002745)1.97059171
122Abnormal platelet volume (HP:0011876)1.95372419
123Increased IgE level (HP:0003212)1.94884986
124Purpura (HP:0000979)1.93846113
125Hypochromic microcytic anemia (HP:0004840)1.93628541
126Acanthocytosis (HP:0001927)1.92919998
127Recurrent bacterial skin infections (HP:0005406)1.91783068
128Bruising susceptibility (HP:0000978)1.91529569
129Stomach cancer (HP:0012126)1.90886567
130Decreased central vision (HP:0007663)1.90063490
131Agammaglobulinemia (HP:0004432)1.89023995
13211 pairs of ribs (HP:0000878)1.88928281
133Increased serum lactate (HP:0002151)1.88063044
134Pulmonary embolism (HP:0002204)1.87963560
135Chronic diarrhea (HP:0002028)1.87419935
136Entropion (HP:0000621)1.86950870
137Congenital stationary night blindness (HP:0007642)1.86110404
138Abnormality of the common coagulation pathway (HP:0010990)1.86041974
139Abnormal rod and cone electroretinograms (HP:0008323)1.83784992
140Gangrene (HP:0100758)1.82535344
141Urticaria (HP:0001025)1.82110163
142Increased serum ferritin (HP:0003281)1.81346564
143Vertigo (HP:0002321)1.80154230
144Hepatosplenomegaly (HP:0001433)1.73306777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.24541112
2NME24.21127717
3MAP4K13.91645444
4RIPK43.87336043
5TLK13.74391231
6SRPK13.26490522
7EIF2AK12.99535575
8JAK32.62005223
9ZAP702.33444406
10TEC2.32824021
11TESK22.24813905
12BTK2.19869709
13KIT2.08030115
14IKBKE1.98706670
15FES1.81372966
16BLK1.80061827
17CDK191.72770442
18SYK1.70656087
19MUSK1.67688945
20NLK1.59990349
21MAP3K121.59652939
22LCK1.58476034
23BMPR21.58359221
24PIK3CG1.57053317
25STK161.55153095
26FRK1.53582978
27BUB11.52247550
28MAP4K21.51805014
29ITK1.49895634
30IRAK41.49256364
31FLT31.43047249
32MKNK21.36718124
33TBK11.36418816
34KDR1.36024823
35CAMKK21.35379129
36TNIK1.33645205
37BMX1.29514769
38ACVR1B1.26305108
39TGFBR11.25752937
40CSF1R1.19888830
41PIM21.14228324
42MAP3K111.13825761
43ZAK1.13600438
44WEE11.13149616
45LYN1.12949239
46MKNK11.09806918
47PTK2B1.08243448
48CDC71.03278441
49BMPR1B1.00730144
50MATK1.00152330
51CLK10.99665373
52PIM10.99233598
53FGFR40.97781070
54IKBKB0.96912917
55GRK50.96088732
56MYLK0.93820006
57HCK0.92627287
58VRK10.92384663
59SIK30.92179680
60FGR0.91762082
61CSK0.87869993
62EIF2AK30.87784780
63IRAK10.87619308
64GRK60.87010865
65TYK20.85351328
66STK100.82240266
67MST40.81530195
68PASK0.81034554
69NEK90.76816033
70MAPK40.74811242
71DYRK30.74637671
72BCKDK0.74353992
73IRAK30.74126834
74MAP2K60.73730867
75MAPK130.73074420
76EEF2K0.69403815
77ADRBK10.68590720
78GRK10.67051276
79NUAK10.65208373
80PDK10.65058417
81JAK10.63855204
82MAP2K30.63672363
83HIPK20.61929586
84SIK20.59970369
85TGFBR20.57514504
86MAPK120.55492056
87MAP3K140.55364355
88DAPK20.53326518
89CDK80.53170959
90JAK20.51827639
91VRK20.51579606
92STK30.51569155
93ILK0.50644976
94CDK70.49273680
95CDK90.48378871
96MAPKAPK30.48203145
97MAP3K50.47370707
98FYN0.46665224
99FGFR30.43733670
100STK40.41683392
101RPS6KB20.39722569
102ADRBK20.39280382
103CDK40.39092739
104RPS6KA40.39068409
105TNK20.38991143
106EIF2AK20.38909015
107AURKB0.38898754
108PLK10.37805713
109ABL10.37289821
110LRRK20.37176696
111CSNK1G10.35816166
112GRK70.35736466
113RPS6KA50.35336766
114DYRK1B0.35199978
115NEK20.35002060
116ATR0.34937494
117PRKD20.34799192
118IGF1R0.34508958
119MAPK110.34486984
120DAPK10.34395642
121CSNK1G30.33670512
122CAMKK10.32794624
123CAMK10.32427657
124TRIM280.32302662
125PRKCD0.29742158
126PRKG20.29033520
127DAPK30.28798772
128AURKA0.28130289
129TAOK10.27902261
130MAP3K80.26914690
131PINK10.26080871
132CSNK2A20.26000305
133OXSR10.25699064
134PRKCQ0.25216903
135CDK60.25210274
136MST1R0.24984267
137YES10.24825281
138MARK30.24806386
139TAOK30.24196661
140PIK3CA0.23844069
141PRKD10.23471416
142CHUK0.22858546
143STK240.21694793
144TRPM70.21367963
145PRKCA0.20614106
146MAPKAPK20.20163055
147ERN10.20013157

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.60719647
2Primary immunodeficiency_Homo sapiens_hsa053404.30077847
3DNA replication_Homo sapiens_hsa030303.18519901
4Type I diabetes mellitus_Homo sapiens_hsa049402.48036908
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.34319555
6Spliceosome_Homo sapiens_hsa030402.30840183
7Mismatch repair_Homo sapiens_hsa034302.27677739
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.26730358
9T cell receptor signaling pathway_Homo sapiens_hsa046602.15798508
10Homologous recombination_Homo sapiens_hsa034402.13496713
11RNA polymerase_Homo sapiens_hsa030202.11464149
12Hematopoietic cell lineage_Homo sapiens_hsa046402.04239879
13Antigen processing and presentation_Homo sapiens_hsa046122.01119512
14Measles_Homo sapiens_hsa051621.98382416
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96550059
16Base excision repair_Homo sapiens_hsa034101.92358034
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.83984314
18Pyrimidine metabolism_Homo sapiens_hsa002401.73020003
19Staphylococcus aureus infection_Homo sapiens_hsa051501.68035275
20Proteasome_Homo sapiens_hsa030501.65765690
21Protein export_Homo sapiens_hsa030601.65438844
22Non-homologous end-joining_Homo sapiens_hsa034501.61954755
23Nucleotide excision repair_Homo sapiens_hsa034201.55180646
24Herpes simplex infection_Homo sapiens_hsa051681.54352146
25Allograft rejection_Homo sapiens_hsa053301.52840982
26Graft-versus-host disease_Homo sapiens_hsa053321.50901904
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.48213815
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46507374
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44687816
30Acute myeloid leukemia_Homo sapiens_hsa052211.41176996
31Sulfur relay system_Homo sapiens_hsa041221.40352043
32Jak-STAT signaling pathway_Homo sapiens_hsa046301.38608449
33Leishmaniasis_Homo sapiens_hsa051401.32110977
34B cell receptor signaling pathway_Homo sapiens_hsa046621.28810875
35Fanconi anemia pathway_Homo sapiens_hsa034601.25397746
36Shigellosis_Homo sapiens_hsa051311.25366594
37Rheumatoid arthritis_Homo sapiens_hsa053231.20259259
38Basal transcription factors_Homo sapiens_hsa030221.19546072
39Other glycan degradation_Homo sapiens_hsa005111.18747572
40Arachidonic acid metabolism_Homo sapiens_hsa005901.18360947
41Regulation of autophagy_Homo sapiens_hsa041401.16566931
42Nitrogen metabolism_Homo sapiens_hsa009101.16124979
43Cell cycle_Homo sapiens_hsa041101.14962670
44p53 signaling pathway_Homo sapiens_hsa041151.08065663
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07784284
46RNA degradation_Homo sapiens_hsa030181.07372069
47Osteoclast differentiation_Homo sapiens_hsa043801.06352300
48Hepatitis B_Homo sapiens_hsa051611.04335197
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03170185
50Autoimmune thyroid disease_Homo sapiens_hsa053201.02153100
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.02143211
52Linoleic acid metabolism_Homo sapiens_hsa005911.02124838
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01384661
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99449120
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98038167
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95442304
57African trypanosomiasis_Homo sapiens_hsa051430.93368640
58RNA transport_Homo sapiens_hsa030130.90514657
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87901635
60Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87212796
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86031717
62Epstein-Barr virus infection_Homo sapiens_hsa051690.85379038
63One carbon pool by folate_Homo sapiens_hsa006700.84364758
64Purine metabolism_Homo sapiens_hsa002300.82683279
65Viral myocarditis_Homo sapiens_hsa054160.81977958
66HTLV-I infection_Homo sapiens_hsa051660.79827918
67Platelet activation_Homo sapiens_hsa046110.78874844
68Collecting duct acid secretion_Homo sapiens_hsa049660.78325449
69Phototransduction_Homo sapiens_hsa047440.77430001
70Malaria_Homo sapiens_hsa051440.75919690
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75317886
72Asthma_Homo sapiens_hsa053100.73755686
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73253892
74Folate biosynthesis_Homo sapiens_hsa007900.69728396
75Influenza A_Homo sapiens_hsa051640.68744909
76Oxidative phosphorylation_Homo sapiens_hsa001900.68052848
77Glycerolipid metabolism_Homo sapiens_hsa005610.67394451
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66095230
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65894671
80Apoptosis_Homo sapiens_hsa042100.64394422
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58750693
82Thyroid cancer_Homo sapiens_hsa052160.58190189
83Systemic lupus erythematosus_Homo sapiens_hsa053220.57510013
84Phagosome_Homo sapiens_hsa041450.57390788
85Olfactory transduction_Homo sapiens_hsa047400.56510574
86mRNA surveillance pathway_Homo sapiens_hsa030150.55340134
87Toxoplasmosis_Homo sapiens_hsa051450.53361812
88Chemokine signaling pathway_Homo sapiens_hsa040620.52547378
89Viral carcinogenesis_Homo sapiens_hsa052030.52446169
90Chronic myeloid leukemia_Homo sapiens_hsa052200.51910578
91Pertussis_Homo sapiens_hsa051330.51761138
92Prolactin signaling pathway_Homo sapiens_hsa049170.50774122
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.50677686
94Serotonergic synapse_Homo sapiens_hsa047260.49593128
95Endocytosis_Homo sapiens_hsa041440.49468103
96Salmonella infection_Homo sapiens_hsa051320.46354530
97Legionellosis_Homo sapiens_hsa051340.45974051
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44927876
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44807706
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44642028
101N-Glycan biosynthesis_Homo sapiens_hsa005100.43993299
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43890108
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.43526688
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41370118
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40744923
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40686024
107Non-small cell lung cancer_Homo sapiens_hsa052230.40667020
108Caffeine metabolism_Homo sapiens_hsa002320.40662140
109Hepatitis C_Homo sapiens_hsa051600.40374997
110Pentose phosphate pathway_Homo sapiens_hsa000300.39019564
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37234650
112VEGF signaling pathway_Homo sapiens_hsa043700.36793703
113Parkinsons disease_Homo sapiens_hsa050120.36574836
114Sulfur metabolism_Homo sapiens_hsa009200.36572190
115Colorectal cancer_Homo sapiens_hsa052100.34759642
116Morphine addiction_Homo sapiens_hsa050320.34461988
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33842875
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.33027765
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32778712
120TNF signaling pathway_Homo sapiens_hsa046680.32413622
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31519395
122Tuberculosis_Homo sapiens_hsa051520.31442742
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29898087
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29564087
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28008852
126Pancreatic secretion_Homo sapiens_hsa049720.27310265
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.26421307
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25637567
129Calcium signaling pathway_Homo sapiens_hsa040200.25577125
130Pancreatic cancer_Homo sapiens_hsa052120.25515539
131Notch signaling pathway_Homo sapiens_hsa043300.23908809
132ABC transporters_Homo sapiens_hsa020100.22993921
133Huntingtons disease_Homo sapiens_hsa050160.22492693

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