SLAMF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.68202192
2germinal center formation (GO:0002467)6.22650576
3natural killer cell activation involved in immune response (GO:0002323)5.92921957
4regulation of chronic inflammatory response (GO:0002676)5.45596685
5negative regulation of protein localization to cell surface (GO:2000009)5.44911412
6regulation of T-helper 1 cell differentiation (GO:0045625)5.38357668
7regulation of vitamin D biosynthetic process (GO:0060556)5.10683469
8type I interferon signaling pathway (GO:0060337)4.95233385
9cellular response to type I interferon (GO:0071357)4.95233385
10response to type I interferon (GO:0034340)4.89335227
11negative regulation of interleukin-12 production (GO:0032695)4.65347628
12cellular response to interleukin-15 (GO:0071350)4.48198271
13regulation of interferon-alpha production (GO:0032647)4.45595115
14regulation of cytokine secretion involved in immune response (GO:0002739)4.37723034
15regulation of regulatory T cell differentiation (GO:0045589)4.31893538
16regulation of isotype switching to IgG isotypes (GO:0048302)4.26557239
17interferon-gamma-mediated signaling pathway (GO:0060333)4.10013855
18regulation of vitamin metabolic process (GO:0030656)4.00282198
19defense response to protozoan (GO:0042832)3.94619806
20ribosomal small subunit assembly (GO:0000028)3.93596425
21T-helper 1 type immune response (GO:0042088)3.92381796
22response to protozoan (GO:0001562)3.89485779
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.89237490
24immunoglobulin mediated immune response (GO:0016064)3.84108468
25T cell migration (GO:0072678)3.80838278
26positive regulation of interferon-alpha production (GO:0032727)3.73543397
27negative regulation of viral genome replication (GO:0045071)3.71549806
28positive regulation of Cdc42 GTPase activity (GO:0043089)3.69666357
29negative T cell selection (GO:0043383)3.69166382
30response to interleukin-15 (GO:0070672)3.67129030
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.66598837
32lipopolysaccharide-mediated signaling pathway (GO:0031663)3.63715819
33positive regulation of natural killer cell differentiation (GO:0032825)3.62716999
34regulation of interleukin-12 production (GO:0032655)3.60935102
35maturation of SSU-rRNA (GO:0030490)3.59251993
36regulation of immunoglobulin secretion (GO:0051023)3.58606858
37viral transcription (GO:0019083)3.57153502
38response to peptidoglycan (GO:0032494)3.55746956
39regulation of dendritic cell antigen processing and presentation (GO:0002604)3.55512725
40positive regulation of defense response to virus by host (GO:0002230)3.55237264
41positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.52495511
42macrophage activation involved in immune response (GO:0002281)3.52291690
43leukocyte degranulation (GO:0043299)3.50811260
44positive regulation of chemokine biosynthetic process (GO:0045080)3.50560828
45regulation of T-helper cell differentiation (GO:0045622)3.50375870
46regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.48742161
47negative regulation of cell killing (GO:0031342)3.45315531
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.45315531
49regulation of gamma-delta T cell activation (GO:0046643)3.45130528
50negative regulation of cytokine production involved in immune response (GO:0002719)3.43678220
51negative thymic T cell selection (GO:0045060)3.43224358
52translational termination (GO:0006415)3.43064946
53positive regulation of heat generation (GO:0031652)3.39078487
54positive regulation of interleukin-12 production (GO:0032735)3.38874326
55regulation of interferon-gamma biosynthetic process (GO:0045072)3.37054389
56cellular response to interferon-gamma (GO:0071346)3.35261855
57activation of MAPKKK activity (GO:0000185)3.34983636
58regulation of fever generation (GO:0031620)3.34255769
59dendritic cell differentiation (GO:0097028)3.33821549
60regulation of type I interferon-mediated signaling pathway (GO:0060338)3.32139172
61positive regulation of gamma-delta T cell activation (GO:0046645)3.30921613
62regulation of podosome assembly (GO:0071801)3.30919772
63positive T cell selection (GO:0043368)3.24246658
64branching involved in labyrinthine layer morphogenesis (GO:0060670)3.23112966
65positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.21493146
66negative regulation of T cell mediated immunity (GO:0002710)3.20883559
67regulation of interferon-beta biosynthetic process (GO:0045357)3.18681481
68regulation of chemokine biosynthetic process (GO:0045073)3.18005855
69positive regulation of type 2 immune response (GO:0002830)3.17864762
70regulation of antigen processing and presentation (GO:0002577)3.17563039
71regulation of B cell receptor signaling pathway (GO:0050855)3.16784996
72mast cell activation (GO:0045576)3.15919871
73positive regulation of NF-kappaB import into nucleus (GO:0042346)3.14850070
74positive regulation of isotype switching (GO:0045830)3.14758463
75positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14598262
76positive regulation of DNA recombination (GO:0045911)3.13991170
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.13712182
78regulation of isotype switching (GO:0045191)3.13702792
79regulation of axon regeneration (GO:0048679)3.13355672
80regulation of neuron projection regeneration (GO:0070570)3.13355672
81response to muramyl dipeptide (GO:0032495)3.13316828
82positive regulation by symbiont of host defense response (GO:0052509)3.11101992
83modulation by symbiont of host defense response (GO:0052031)3.11101992
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.11101992
85modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.11101992
86positive regulation by organism of defense response of other organism involved in symbiotic interact3.11101992
87modulation by symbiont of host immune response (GO:0052553)3.11101992
88positive regulation of antigen processing and presentation (GO:0002579)3.10996942
89B cell mediated immunity (GO:0019724)3.10765885
90alpha-beta T cell differentiation (GO:0046632)3.10620824
91regulation of T cell tolerance induction (GO:0002664)3.09318809
92antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.08878326
93ribonucleoprotein complex biogenesis (GO:0022613)3.08524876
94regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.08159986
95regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.06190318
96regulation of T cell receptor signaling pathway (GO:0050856)3.04649585
97response to interferon-gamma (GO:0034341)3.04345950
98T cell lineage commitment (GO:0002360)3.03564278
99positive regulation of interferon-beta production (GO:0032728)3.03203128
100regulation of alpha-beta T cell proliferation (GO:0046640)3.02822446
101antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.02383028
102negative regulation of nitric oxide biosynthetic process (GO:0045019)3.01752089
103regulation of interleukin-2 biosynthetic process (GO:0045076)3.01264666
104B cell proliferation (GO:0042100)3.00610333
105ribosomal large subunit biogenesis (GO:0042273)3.00098040
106positive regulation of cytokine biosynthetic process (GO:0042108)2.99762205
107regulation of interleukin-12 biosynthetic process (GO:0045075)2.99702314
108positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.98598071
109regulation of inflammatory response to antigenic stimulus (GO:0002861)2.98315093
110positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.98296846
111negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.98057841
112alpha-beta T cell activation (GO:0046631)2.96566343
113positive regulation of B cell proliferation (GO:0030890)2.95346215
114positive regulation of T-helper cell differentiation (GO:0045624)2.95056116
115negative regulation of myeloid cell apoptotic process (GO:0033033)2.92648599
116interferon-gamma production (GO:0032609)2.89796405
117regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.89672513
118mature B cell differentiation (GO:0002335)2.88214457
119dopamine transport (GO:0015872)2.87226143
120NIK/NF-kappaB signaling (GO:0038061)2.87026496
121positive regulation of interleukin-2 production (GO:0032743)2.86269800
122mast cell degranulation (GO:0043303)2.84311883
123mast cell activation involved in immune response (GO:0002279)2.84311883
124CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.81721984
125myeloid dendritic cell activation (GO:0001773)2.81136629
126T cell selection (GO:0045058)2.79376357
127T cell homeostasis (GO:0043029)2.79019215
128regulation of immunoglobulin production (GO:0002637)2.77607853
129positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.77467301
130positive regulation of protein homodimerization activity (GO:0090073)2.77466011
131lymphoid progenitor cell differentiation (GO:0002320)2.75931112
132transcription elongation from RNA polymerase I promoter (GO:0006362)2.75301296
133cotranslational protein targeting to membrane (GO:0006613)2.75118829
134activated T cell proliferation (GO:0050798)2.73622563
135negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.72991189
136natural killer cell activation (GO:0030101)2.72534375
137regulation of immunoglobulin mediated immune response (GO:0002889)2.71748805
138SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.70438608
139positive regulation of immunoglobulin mediated immune response (GO:0002891)2.69568083
140positive regulation of B cell mediated immunity (GO:0002714)2.69568083
141lymphocyte activation involved in immune response (GO:0002285)2.69512336
142regulation of B cell mediated immunity (GO:0002712)2.69265659
143regulation of interleukin-2 production (GO:0032663)2.68516370
144protein targeting to ER (GO:0045047)2.68112632
145tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68085764
146RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68085764
147positive regulation of humoral immune response (GO:0002922)2.67534369
148positive regulation of T cell cytokine production (GO:0002726)2.66274762
149positive thymic T cell selection (GO:0045059)2.65935199
150myeloid dendritic cell differentiation (GO:0043011)2.63309880
151somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.62839944
152isotype switching (GO:0045190)2.62839944
153somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.62839944
154cellular protein complex disassembly (GO:0043624)2.62446568
155transcription elongation from RNA polymerase III promoter (GO:0006385)2.61881031
156termination of RNA polymerase III transcription (GO:0006386)2.61881031
157T-helper cell differentiation (GO:0042093)2.61508758
158CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.61508758
159regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.59762146
160chaperone-mediated protein transport (GO:0072321)2.59730033
161positive regulation of interleukin-17 production (GO:0032740)2.58322445
162viral life cycle (GO:0019058)2.58290581
163rRNA processing (GO:0006364)2.56212868
164deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.56190619
165translational elongation (GO:0006414)2.55404956
166establishment of protein localization to endoplasmic reticulum (GO:0072599)2.54741425
167CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.54421923
168tumor necrosis factor-mediated signaling pathway (GO:0033209)2.54398809
169T cell differentiation (GO:0030217)2.54164854
170protein localization to endoplasmic reticulum (GO:0070972)2.53684370
171T cell receptor signaling pathway (GO:0050852)2.52993345
172nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.51944742
173regulation of memory T cell differentiation (GO:0043380)2.51615839
174positive regulation of interleukin-4 production (GO:0032753)2.51452606
175termination of RNA polymerase I transcription (GO:0006363)2.51155118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.18248442
2RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.92578125
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.54941961
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.48606997
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.48327557
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.43987695
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30825810
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09362019
9NOTCH1_21737748_ChIP-Seq_TLL_Human3.07630886
10EZH2_22144423_ChIP-Seq_EOC_Human2.97348169
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.73357090
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72596341
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.72469960
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62976482
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.59939850
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58629355
17TAF15_26573619_Chip-Seq_HEK293_Human2.56845101
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.42336241
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.32485379
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31673632
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.27416011
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.24239845
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.23745480
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22117208
25* MAF_26560356_Chip-Seq_TH1_Human2.20560314
26E2F7_22180533_ChIP-Seq_HELA_Human2.14742335
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13984508
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09483710
29* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05166824
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01811589
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99814275
32* GBX2_23144817_ChIP-Seq_PC3_Human1.99792300
33MYC_22102868_ChIP-Seq_BL_Human1.96693932
34* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.96612545
35GATA1_22025678_ChIP-Seq_K562_Human1.96499854
36FUS_26573619_Chip-Seq_HEK293_Human1.96254653
37MYB_26560356_Chip-Seq_TH1_Human1.95685364
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.94970007
39VDR_22108803_ChIP-Seq_LS180_Human1.92847316
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92371220
41VDR_21846776_ChIP-Seq_THP-1_Human1.91061270
42SPI1_23547873_ChIP-Seq_NB4_Human1.90610897
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.90569939
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80892310
45VDR_24763502_ChIP-Seq_THP-1_Human1.80833920
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76067388
47VDR_24787735_ChIP-Seq_THP-1_Human1.74333216
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73839942
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73246957
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72270548
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.70746297
52IGF1R_20145208_ChIP-Seq_DFB_Human1.70112792
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67451645
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66705423
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64703219
56ELK1_19687146_ChIP-ChIP_HELA_Human1.63046026
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62352511
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60783136
59* NFE2_27457419_Chip-Seq_LIVER_Mouse1.58757717
60NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.58027789
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57834803
62* GATA3_27048872_Chip-Seq_THYMUS_Human1.57277346
63UTX_26944678_Chip-Seq_JUKART_Human1.56475475
64* MAF_26560356_Chip-Seq_TH2_Human1.54942410
65EWS_26573619_Chip-Seq_HEK293_Human1.53229892
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.53199696
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50174103
68RUNX_20019798_ChIP-Seq_JUKART_Human1.47813523
69* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46871532
70SPI1_23127762_ChIP-Seq_K562_Human1.46578895
71JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45712667
72SCL_19346495_ChIP-Seq_HPC-7_Human1.45156571
73* GATA3_26560356_Chip-Seq_TH2_Human1.44781289
74* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.41311050
75IRF1_19129219_ChIP-ChIP_H3396_Human1.39079925
76VDR_23849224_ChIP-Seq_CD4+_Human1.39040682
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38989996
78* NANOG_18555785_Chip-Seq_ESCs_Mouse1.38880985
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38090315
80P300_19829295_ChIP-Seq_ESCs_Human1.37431006
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.36085884
82* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35295102
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34484842
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.33821859
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.33546639
86* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.32339090
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.31403588
88* NMYC_18555785_Chip-Seq_ESCs_Mouse1.31343703
89* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30388037
90* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30180355
91IRF8_21731497_ChIP-ChIP_J774_Mouse1.29322932
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28818008
93* EZH2_27294783_Chip-Seq_NPCs_Mouse1.28778944
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28336235
95MYC_18555785_ChIP-Seq_MESCs_Mouse1.27373143
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.27261727
97* P300_18555785_Chip-Seq_ESCs_Mouse1.26916057
98MYC_18940864_ChIP-ChIP_HL60_Human1.26908278
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26680164
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26325281
101PU_27001747_Chip-Seq_BMDM_Mouse1.26129956
102* E2F1_18555785_Chip-Seq_ESCs_Mouse1.25257832
103* STAT3_18555785_Chip-Seq_ESCs_Mouse1.24278368
104KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24220817
105* CMYC_18555785_Chip-Seq_ESCs_Mouse1.22103675
106TP63_17297297_ChIP-ChIP_HaCaT_Human1.21698982
107TP63_19390658_ChIP-ChIP_HaCaT_Human1.21418301
108POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21266820
109* OCT4_18555785_Chip-Seq_ESCs_Mouse1.20053842
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20031218
111* P53_22387025_ChIP-Seq_ESCs_Mouse1.19491459
112* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19342087
113* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18721261
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16696616
115* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15772267
116* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15625030
117* KLF4_18555785_Chip-Seq_ESCs_Mouse1.14813019
118* ZFX_18555785_Chip-Seq_ESCs_Mouse1.14711341
119LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14565896
120* PRDM14_20953172_ChIP-Seq_ESCs_Human1.14564085
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14363836
122RNF2_27304074_Chip-Seq_NSC_Mouse1.13309857
123* SOX2_18555785_Chip-Seq_ESCs_Mouse1.12372930
124TCF7_22412390_ChIP-Seq_EML_Mouse1.12210471
125CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11487567
126* MYB_26560356_Chip-Seq_TH2_Human1.10868573
127VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09045995
128FOXP3_21729870_ChIP-Seq_TREG_Human1.08221008
129* PU1_27457419_Chip-Seq_LIVER_Mouse1.07526805
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06755414
131CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06734968
132KDM2B_26808549_Chip-Seq_DND41_Human1.06187233
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05481898
134MYC_19079543_ChIP-ChIP_MESCs_Mouse1.05068487
135ER_23166858_ChIP-Seq_MCF-7_Human1.04442438
136GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04433693
137* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03940800
138PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03254580
139* CTCF_18555785_Chip-Seq_ESCs_Mouse1.02677886
140KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02315080
141KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00831742
142* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00617312
143TTF2_22483619_ChIP-Seq_HELA_Human0.98148311
144PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97027210
145IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96651673
146SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96360855
147* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95889430
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95215126
149TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95215126
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.95021077
151TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94980238
152CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93665824
153CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93638432
154TAL1_26923725_Chip-Seq_HPCs_Mouse0.92500917
155ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92423484
156EZH2_27304074_Chip-Seq_ESCs_Mouse0.91519361
157PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91273592
158CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89940274
159ELK3_25401928_ChIP-Seq_HUVEC_Human0.89535346
160* STAT1_20625510_ChIP-Seq_HELA_Human0.85210589
161EGR1_19032775_ChIP-ChIP_M12_Human0.84712802
162GATA2_21666600_ChIP-Seq_HMVEC_Human0.83519065
163LXR_22292898_ChIP-Seq_THP-1_Human0.83390152
164GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81411846
165GATA1_19941826_ChIP-Seq_K562_Human0.80902997
166TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.80163220
167SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79423005
168BCL6_27268052_Chip-Seq_Bcells_Human0.77886740
169TFEB_21752829_ChIP-Seq_HELA_Human0.77539382
170KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.71167195
171KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.71167195
172KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.71167195
173* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.70324443
174BCOR_27268052_Chip-Seq_Bcells_Human0.69154217
175ELF1_20517297_ChIP-Seq_JURKAT_Human0.68211335
176TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67754077
177CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66221408
178GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65981582
179TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.65128543
180SMRT_27268052_Chip-Seq_Bcells_Human0.65117885
181NCOR1_26117541_ChIP-Seq_K562_Human0.63260028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.44502420
2MP0003880_abnormal_central_pattern3.82213637
3MP0005671_abnormal_response_to3.27525899
4MP0003763_abnormal_thymus_physiology3.09426889
5MP0006292_abnormal_olfactory_placode2.97535419
6MP0001835_abnormal_antigen_presentation2.70222561
7MP0001188_hyperpigmentation2.61001601
8MP0003300_gastrointestinal_ulcer2.56198444
9MP0005409_darkened_coat_color2.46576769
10MP0001800_abnormal_humoral_immune2.28273760
11MP0008057_abnormal_DNA_replication2.23632417
12MP0000685_abnormal_immune_system2.21650527
13MP0005423_abnormal_somatic_nervous2.19172457
14MP0005000_abnormal_immune_tolerance2.17621371
15MP0009379_abnormal_foot_pigmentation2.15600904
16MP0001790_abnormal_immune_system2.11893159
17MP0005387_immune_system_phenotype2.11893159
18MP0004947_skin_inflammation2.09236827
19MP0003136_yellow_coat_color2.04061531
20MP0009764_decreased_sensitivity_to2.03299945
21MP0002148_abnormal_hypersensitivity_rea2.02886019
22* MP0002723_abnormal_immune_serum2.01311998
23MP0001529_abnormal_vocalization1.96174462
24MP0004381_abnormal_hair_follicle1.91160943
25MP0001533_abnormal_skeleton_physiology1.91050476
26MP0001501_abnormal_sleep_pattern1.86923470
27MP0005058_abnormal_lysosome_morphology1.86187131
28* MP0002420_abnormal_adaptive_immunity1.83725981
29* MP0002452_abnormal_antigen_presenting1.81988952
30* MP0001819_abnormal_immune_cell1.80239962
31MP0003724_increased_susceptibility_to1.79480709
32MP0009785_altered_susceptibility_to1.78765111
33MP0002398_abnormal_bone_marrow1.78418309
34MP0005174_abnormal_tail_pigmentation1.77253213
35MP0002139_abnormal_hepatobiliary_system1.74935810
36MP0001905_abnormal_dopamine_level1.70642086
37MP0000703_abnormal_thymus_morphology1.67986213
38MP0003075_altered_response_to1.66640160
39MP0004510_myositis1.65828079
40MP0001853_heart_inflammation1.65290650
41* MP0005025_abnormal_response_to1.59757387
42MP0008469_abnormal_protein_level1.59593787
43MP0002396_abnormal_hematopoietic_system1.59261296
44MP0002163_abnormal_gland_morphology1.58080294
45MP0002277_abnormal_respiratory_mucosa1.55919661
46MP0000716_abnormal_immune_system1.55597575
47MP0001873_stomach_inflammation1.54214948
48MP0005310_abnormal_salivary_gland1.54079983
49MP0002102_abnormal_ear_morphology1.50126557
50MP0000689_abnormal_spleen_morphology1.49474196
51MP0004742_abnormal_vestibular_system1.47564089
52MP0002722_abnormal_immune_system1.44373781
53MP0002006_tumorigenesis1.41833141
54MP0002332_abnormal_exercise_endurance1.39404896
55MP0009745_abnormal_behavioral_response1.38430058
56MP0008058_abnormal_DNA_repair1.37208803
57MP0003866_abnormal_defecation1.36922050
58MP0002405_respiratory_system_inflammati1.36217309
59MP0002166_altered_tumor_susceptibility1.34704139
60MP0008004_abnormal_stomach_pH1.34278470
61MP0009840_abnormal_foam_cell1.34146162
62MP0002009_preneoplasia1.32863151
63MP0000566_synostosis1.32441658
64MP0003453_abnormal_keratinocyte_physiol1.32424806
65MP0005075_abnormal_melanosome_morpholog1.32237703
66MP0003436_decreased_susceptibility_to1.32228184
67MP0002736_abnormal_nociception_after1.31050061
68MP0009278_abnormal_bone_marrow1.30822263
69MP0009333_abnormal_splenocyte_physiolog1.30015252
70MP0000343_altered_response_to1.29905498
71MP0001968_abnormal_touch/_nociception1.29510935
72MP0001486_abnormal_startle_reflex1.29259747
73MP0003448_altered_tumor_morphology1.29125025
74MP0006276_abnormal_autonomic_nervous1.28863175
75MP0002933_joint_inflammation1.28048060
76MP0005379_endocrine/exocrine_gland_phen1.25905241
77MP0002095_abnormal_skin_pigmentation1.25646329
78MP0001545_abnormal_hematopoietic_system1.23091798
79MP0005397_hematopoietic_system_phenotyp1.23091798
80MP0002429_abnormal_blood_cell1.23050468
81MP0008877_abnormal_DNA_methylation1.22041941
82MP0005167_abnormal_blood-brain_barrier1.20223625
83MP0000604_amyloidosis1.18818737
84MP0002572_abnormal_emotion/affect_behav1.18370230
85MP0000015_abnormal_ear_pigmentation1.18073143
86MP0000858_altered_metastatic_potential1.16529046
87MP0002138_abnormal_hepatobiliary_system1.15597977
88MP0000465_gastrointestinal_hemorrhage1.15009926
89MP0003172_abnormal_lysosome_physiology1.13597570
90* MP0002419_abnormal_innate_immunity1.13521957
91MP0002272_abnormal_nervous_system1.13280942
92MP0002132_abnormal_respiratory_system1.11455306
93MP0005171_absent_coat_pigmentation1.11110101
94MP0003635_abnormal_synaptic_transmissio1.10637247
95MP0005166_decreased_susceptibility_to1.09397098
96MP0002998_abnormal_bone_remodeling1.07561729
97MP0003938_abnormal_ear_development1.07300084
98MP0010094_abnormal_chromosome_stability1.04852602
99MP0002063_abnormal_learning/memory/cond1.03447711
100MP0003806_abnormal_nucleotide_metabolis1.02424566
101MP0004859_abnormal_synaptic_plasticity1.01312082
102MP0002735_abnormal_chemical_nociception0.99900281
103MP0009763_increased_sensitivity_to0.98339375
104MP0006082_CNS_inflammation0.95885324
105MP0002254_reproductive_system_inflammat0.93704455
106MP0010155_abnormal_intestine_physiology0.93308441
107MP0004270_analgesia0.93254655
108MP0003787_abnormal_imprinting0.93222949
109MP0001440_abnormal_grooming_behavior0.92158718
110MP0008995_early_reproductive_senescence0.91687522
111MP0004142_abnormal_muscle_tone0.90388549
112MP0001663_abnormal_digestive_system0.89293144
113MP0005451_abnormal_body_composition0.88953254
114MP0003195_calcinosis0.88186224
115MP0003941_abnormal_skin_development0.87716030
116MP0003786_premature_aging0.86609214
117MP0001986_abnormal_taste_sensitivity0.85228217
118MP0006054_spinal_hemorrhage0.84823611
119MP0003656_abnormal_erythrocyte_physiolo0.84441229
120MP0002064_seizures0.84333842
121MP0003091_abnormal_cell_migration0.83905935
122MP0001542_abnormal_bone_strength0.83895060
123MP0001485_abnormal_pinna_reflex0.83753830
124MP0003646_muscle_fatigue0.82872608
125MP0009765_abnormal_xenobiotic_induced0.80549179
126MP0002067_abnormal_sensory_capabilities0.76727258
127MP0005390_skeleton_phenotype0.76170237
128MP0000490_abnormal_crypts_of0.74230364
129MP0003828_pulmonary_edema0.73864819
130MP0005645_abnormal_hypothalamus_physiol0.73289113
131MP0005165_increased_susceptibility_to0.73130225
132MP0003690_abnormal_glial_cell0.72442780
133MP0003045_fibrosis0.72009056
134MP0005464_abnormal_platelet_physiology0.71717872
135MP0001845_abnormal_inflammatory_respons0.69588518
136MP0000613_abnormal_salivary_gland0.69369441
137MP0002184_abnormal_innervation0.69360038
138MP0004808_abnormal_hematopoietic_stem0.68992377
139MP0008874_decreased_physiological_sensi0.68593354
140MP0002693_abnormal_pancreas_physiology0.66215683
141MP0005164_abnormal_response_to0.65772031
142MP0001348_abnormal_lacrimal_gland0.62304655
143MP0010307_abnormal_tumor_latency0.62244338
144MP0003183_abnormal_peptide_metabolism0.61246595
145MP0005266_abnormal_metabolism0.57895959
146MP0005647_abnormal_sex_gland0.57521264
147MP0005535_abnormal_body_temperature0.56375420
148MP0005076_abnormal_cell_differentiation0.53605138
149MP0004883_abnormal_blood_vessel0.52932551
150MP0000609_abnormal_liver_physiology0.52806761
151MP0000249_abnormal_blood_vessel0.51656199
152MP0001919_abnormal_reproductive_system0.51327316
153MP0000920_abnormal_myelination0.50234897
154MP0003795_abnormal_bone_structure0.50114002

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)5.44353159
2Myositis (HP:0100614)4.80464513
3Abnormality of glycolipid metabolism (HP:0010969)4.63664854
4Abnormality of liposaccharide metabolism (HP:0010968)4.63664854
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.63664854
6Granulocytopenia (HP:0001913)4.28463327
7Stomatitis (HP:0010280)4.10345572
8Autoimmune hemolytic anemia (HP:0001890)4.06973157
9Autoimmune thrombocytopenia (HP:0001973)4.04672324
10Pulmonary infiltrates (HP:0002113)4.02823355
11Panhypogammaglobulinemia (HP:0003139)3.83621186
12Keratoconjunctivitis (HP:0001096)3.82585031
13Recurrent bacterial skin infections (HP:0005406)3.81394207
14IgG deficiency (HP:0004315)3.74976382
15Gangrene (HP:0100758)3.57626492
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.51595791
17Reticulocytopenia (HP:0001896)3.47269147
18Vacuolated lymphocytes (HP:0001922)3.39677505
19Systemic lupus erythematosus (HP:0002725)3.37326605
20Recurrent abscess formation (HP:0002722)3.33894667
21Loss of speech (HP:0002371)3.30009225
22Severe combined immunodeficiency (HP:0004430)3.20963374
23Hemoptysis (HP:0002105)3.18487282
24Disinhibition (HP:0000734)3.15928484
25IgM deficiency (HP:0002850)3.14518864
26Joint swelling (HP:0001386)3.11438877
27Exertional dyspnea (HP:0002875)3.09853150
28Renal Fanconi syndrome (HP:0001994)3.03808914
29Increased hepatocellular lipid droplets (HP:0006565)3.03209548
30Dysostosis multiplex (HP:0000943)3.02718907
31Increased IgM level (HP:0003496)2.99459885
32T lymphocytopenia (HP:0005403)2.95718639
33Increased cerebral lipofuscin (HP:0011813)2.92123147
34Abnormality of T cell number (HP:0011839)2.91215044
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.89452576
36Abnormality of cells of the lymphoid lineage (HP:0012140)2.88022177
37Hypergammaglobulinemia (HP:0010702)2.87866470
38Chromsome breakage (HP:0040012)2.84265543
39Abnormality of the axillary hair (HP:0100134)2.84014996
40Abnormality of secondary sexual hair (HP:0009888)2.84014996
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.77792774
42Mutism (HP:0002300)2.76619104
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75405287
44Abnormality of the pleura (HP:0002103)2.73046017
45Polyneuropathy (HP:0001271)2.71064613
46Parakeratosis (HP:0001036)2.70511294
47Arterial thrombosis (HP:0004420)2.70258307
48Abnormality of B cell number (HP:0010975)2.69556289
49B lymphocytopenia (HP:0010976)2.69556289
50Abnormality of cells of the erythroid lineage (HP:0012130)2.69037540
51Progressive external ophthalmoplegia (HP:0000590)2.67882058
52Interstitial pulmonary disease (HP:0006530)2.65320112
53Gastrointestinal infarctions (HP:0005244)2.64589953
54Recurrent skin infections (HP:0001581)2.63127107
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.63079939
56Macrocytic anemia (HP:0001972)2.60863275
57Abnormal number of erythroid precursors (HP:0012131)2.56816377
58Chronic mucocutaneous candidiasis (HP:0002728)2.54353892
59Recurrent cutaneous fungal infections (HP:0011370)2.54353892
60Recurrent fungal infections (HP:0002841)2.47639360
61IgA deficiency (HP:0002720)2.46868437
62Agammaglobulinemia (HP:0004432)2.46832001
63Pallor (HP:0000980)2.46679199
64Abnormality of T cells (HP:0002843)2.45782908
65Restrictive lung disease (HP:0002091)2.44987132
66Emphysema (HP:0002097)2.44242743
67Anorexia (HP:0002039)2.43820159
68Recurrent gram-negative bacterial infections (HP:0005420)2.43625369
69Arthralgia (HP:0002829)2.42704369
70Hepatosplenomegaly (HP:0001433)2.40072880
71Diplopia (HP:0000651)2.39953187
72Abnormality of binocular vision (HP:0011514)2.39953187
73Abnormality of eosinophils (HP:0001879)2.37403085
74Chronic sinusitis (HP:0011109)2.37347183
75Abnormality of macrophages (HP:0004311)2.36914923
76Nuclear cataract (HP:0100018)2.36768784
77Increased serum ferritin (HP:0003281)2.35990837
78Combined immunodeficiency (HP:0005387)2.35681568
79Duplicated collecting system (HP:0000081)2.35346414
80Recurrent viral infections (HP:0004429)2.34276276
81Elevated erythrocyte sedimentation rate (HP:0003565)2.34202194
82Pulmonary embolism (HP:0002204)2.33847432
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.32903841
84Keratitis (HP:0000491)2.31731114
85Chronic obstructive pulmonary disease (HP:0006510)2.31351473
86Obstructive lung disease (HP:0006536)2.31351473
87Recurrent bronchitis (HP:0002837)2.30293886
883-Methylglutaconic aciduria (HP:0003535)2.28385982
89Chronic otitis media (HP:0000389)2.25333078
90Lipid accumulation in hepatocytes (HP:0006561)2.22455873
91Optic neuritis (HP:0100653)2.22346869
92Retrobulbar optic neuritis (HP:0100654)2.22346869
93Mitochondrial inheritance (HP:0001427)2.22030900
94Colitis (HP:0002583)2.21131857
95Glomerulonephritis (HP:0000099)2.20654606
96Glomerulopathy (HP:0100820)2.20521494
97Focal motor seizures (HP:0011153)2.19371978
98Abnormality of the pericardium (HP:0001697)2.15911545
99Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.14226093
100Meningitis (HP:0001287)2.13376106
101Abnormality of the renal collecting system (HP:0004742)2.11956091
102Abnormality of renal resorption (HP:0011038)2.11201533
103Eosinophilia (HP:0001880)2.09648346
104Acute necrotizing encephalopathy (HP:0006965)2.09566237
105Hematochezia (HP:0002573)2.08914198
106Urticaria (HP:0001025)2.08616510
107Respiratory difficulties (HP:0002880)2.08587693
108Basal ganglia calcification (HP:0002135)2.07593684
109Abnormality of the prostate (HP:0008775)2.07399541
110Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06681347
111Abnormality of polysaccharide metabolism (HP:0011012)2.06681347
112Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06681347
113Memory impairment (HP:0002354)2.03764124
114Abnormal ciliary motility (HP:0012262)2.03495275
115Pancytopenia (HP:0001876)2.02727520
116Thyroiditis (HP:0100646)2.01855232
117Lymphoma (HP:0002665)2.01215930
118Leukocytosis (HP:0001974)2.00921365
119Asplenia (HP:0001746)2.00453870
120Abnormality of the endocardium (HP:0004306)1.99799817
121Encephalitis (HP:0002383)1.99729964
122Vertigo (HP:0002321)1.97642775
123Aplastic anemia (HP:0001915)1.96377985
124Increased intramyocellular lipid droplets (HP:0012240)1.94124831
125Hepatocellular necrosis (HP:0001404)1.94038647
126Hypertensive crisis (HP:0100735)1.93713225
127Mucopolysacchariduria (HP:0008155)1.93549522
128Urinary glycosaminoglycan excretion (HP:0003541)1.93549522
129Abnormality of the preputium (HP:0100587)1.92821090
130Thrombocytosis (HP:0001894)1.92744805
131Abnormality of T cell physiology (HP:0011840)1.90226830
132Abnormal respiratory epithelium morphology (HP:0012253)1.89316841
133Abnormal respiratory motile cilium morphology (HP:0005938)1.89316841
134Absent/shortened dynein arms (HP:0200106)1.88810641
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.88810641
136Vasculitis (HP:0002633)1.88701062
137Abnormality of DNA repair (HP:0003254)1.85576583
138Recurrent sinusitis (HP:0011108)1.84897386
139Gastrointestinal stroma tumor (HP:0100723)1.84469222
140Increased CSF lactate (HP:0002490)1.83924027
141White forelock (HP:0002211)1.82565508
142Fair hair (HP:0002286)1.80339700
143Mediastinal lymphadenopathy (HP:0100721)1.80240742
144Lymphopenia (HP:0001888)1.80077009
145Conical tooth (HP:0000698)1.78350554
146Clubbing of toes (HP:0100760)1.77236073
147Keratoconjunctivitis sicca (HP:0001097)1.76502126
148Aplasia/Hypoplasia of the spleen (HP:0010451)1.75923246
149Type 2 muscle fiber atrophy (HP:0003554)1.75498002
150Abnormality of chromosome stability (HP:0003220)1.75155700
151Increased IgE level (HP:0003212)1.75069853
152Erythroderma (HP:0001019)1.74894887
153Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.74523871
154Decreased activity of mitochondrial respiratory chain (HP:0008972)1.74523871
155Chronic diarrhea (HP:0002028)1.74512230
156Eczematoid dermatitis (HP:0000976)1.74043687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.40510776
2STK163.62173894
3TBK13.01946976
4MAP4K12.87014729
5PRPF4B2.77153583
6TAOK22.64340943
7RIPK42.64162286
8CASK2.58943182
9MAP3K122.33709728
10MATK2.31769740
11IRAK32.17644233
12IRAK42.16377308
13EPHA42.16088736
14BMPR22.02615124
15NME11.91513814
16SRPK11.87228592
17DDR21.84693841
18RIPK11.83941777
19JAK11.79838366
20TNIK1.78013197
21MAP2K71.75603135
22TAOK31.69523144
23JAK31.61707592
24MAP3K111.58034926
25MAP3K141.56394569
26GRK71.56020506
27MOS1.55715547
28IKBKB1.55665078
29IRAK21.49148783
30FES1.48951303
31ADRBK21.48160502
32FGR1.46678153
33SYK1.46044817
34MKNK21.46003879
35TEC1.44591996
36PNCK1.43141291
37NME21.40002030
38NTRK31.36095020
39MKNK11.35783606
40TAOK11.34522245
41MST41.34302400
42ZAP701.31384054
43BLK1.29955298
44IRAK11.23260388
45MUSK1.22518310
46CDC42BPA1.20745093
47BRD41.20330264
48EIF2AK11.18634581
49CLK11.17538222
50IKBKE1.17397374
51ERN11.11539450
52PRKD21.10762570
53JAK21.10527227
54* LCK1.08984079
55MAP3K31.08335158
56PIM11.07910298
57GRK61.07784748
58CSF1R1.07507899
59STK101.06448562
60EIF2AK31.03872631
61MAP3K131.02793899
62SIK20.98596659
63VRK10.98158138
64BTK0.97468855
65BMPR1B0.95716081
66PRKCQ0.95538948
67* LYN0.94124868
68MAP2K30.93364692
69NLK0.93085464
70MAP3K50.92945125
71ITK0.91736549
72KIT0.91689905
73EIF2AK20.90489185
74FGFR40.90216132
75TNK20.86857262
76YES10.86201584
77TLK10.86136046
78TGFBR20.83667227
79NEK90.81900474
80HCK0.81510974
81TYRO30.80177454
82MARK30.79754664
83NUAK10.78643180
84CDK80.74018985
85CDK30.72022804
86TSSK60.69751148
87RPS6KA50.69009462
88EPHA30.68859089
89HIPK20.68115536
90PLK40.67535857
91MAP3K10.66210438
92ZAK0.63710433
93PBK0.63033951
94CHUK0.62879253
95PKN10.59816288
96ROCK20.59681374
97CAMK2B0.59518612
98NEK60.59207013
99CDK190.58940855
100GRK10.58916283
101TYK20.58601898
102ACVR1B0.56783768
103PLK20.56074412
104CDK40.52721005
105CSK0.52637119
106MAPK40.50988927
107MAP3K40.50826379
108MAPK110.50617161
109TGFBR10.49044059
110STK240.46953859
111TIE10.45707521
112FGFR30.45622311
113CAMK2A0.44712272
114BUB10.44255735
115RAF10.44223794
116CDC70.42909884
117GRK50.42294823
118DAPK10.42089246
119MAPK130.42075549
120STK390.41833909
121PDK10.41720356
122INSR0.41125462
123ATR0.41003008
124DYRK20.38821200
125DAPK30.37443513
126MAPK70.36568327
127TESK20.36533612
128PIM20.36457167
129MAPKAPK50.34437564
130CDK60.34409493
131DYRK1A0.34309595
132MAP2K60.34201638
133SIK30.33891884
134KDR0.32768923
135TTK0.32257182
136CAMK10.32254490
137PINK10.31301719
138MAPKAPK20.29447485
139EGFR0.27359546
140ABL10.22872871
141MELK0.21675227
142PRKCD0.21633200
143CAMKK20.20447600
144ABL20.19058148
145MAPK30.18076287
146ARAF0.17615209
147DAPK20.16975610
148RPS6KC10.15731259
149RPS6KL10.15731259
150DYRK30.15513311
151EPHB10.13394234
152RPS6KA60.11966850
153PRKCH0.11547794

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.54301716
2Ribosome_Homo sapiens_hsa030103.44309126
3Allograft rejection_Homo sapiens_hsa053302.87325760
4Graft-versus-host disease_Homo sapiens_hsa053322.67359805
5RNA polymerase_Homo sapiens_hsa030202.58997852
6Autoimmune thyroid disease_Homo sapiens_hsa053202.37103037
7Staphylococcus aureus infection_Homo sapiens_hsa051502.18712758
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.15677539
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.08443210
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04436814
11Nicotine addiction_Homo sapiens_hsa050332.01476979
12T cell receptor signaling pathway_Homo sapiens_hsa046601.96202189
13Fanconi anemia pathway_Homo sapiens_hsa034601.92530459
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82297041
15Asthma_Homo sapiens_hsa053101.81681025
16Viral myocarditis_Homo sapiens_hsa054161.80282150
17Proteasome_Homo sapiens_hsa030501.78348575
18Homologous recombination_Homo sapiens_hsa034401.70831305
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69104281
20Mismatch repair_Homo sapiens_hsa034301.68145792
21Oxidative phosphorylation_Homo sapiens_hsa001901.66371974
22Type I diabetes mellitus_Homo sapiens_hsa049401.62701643
23Spliceosome_Homo sapiens_hsa030401.61185354
24DNA replication_Homo sapiens_hsa030301.61174125
25Toxoplasmosis_Homo sapiens_hsa051451.60770971
26Hematopoietic cell lineage_Homo sapiens_hsa046401.55955987
27Legionellosis_Homo sapiens_hsa051341.55215357
28Other glycan degradation_Homo sapiens_hsa005111.51565561
29Non-homologous end-joining_Homo sapiens_hsa034501.38312191
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.37868753
31Basal transcription factors_Homo sapiens_hsa030221.32266359
32Pyrimidine metabolism_Homo sapiens_hsa002401.31799300
33Nucleotide excision repair_Homo sapiens_hsa034201.29091019
34* Measles_Homo sapiens_hsa051621.28287139
35RNA degradation_Homo sapiens_hsa030181.27266041
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22163091
37Hepatitis C_Homo sapiens_hsa051601.22035991
38Alzheimers disease_Homo sapiens_hsa050101.21383884
39Salmonella infection_Homo sapiens_hsa051321.20954433
40Lysosome_Homo sapiens_hsa041421.20921795
41Phototransduction_Homo sapiens_hsa047441.20909712
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19307544
43Parkinsons disease_Homo sapiens_hsa050121.18278377
44Rheumatoid arthritis_Homo sapiens_hsa053231.10196124
45Apoptosis_Homo sapiens_hsa042101.07878234
46Serotonergic synapse_Homo sapiens_hsa047261.05153282
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03262172
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02056590
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01505424
50Huntingtons disease_Homo sapiens_hsa050160.99771561
51B cell receptor signaling pathway_Homo sapiens_hsa046620.97660482
52Herpes simplex infection_Homo sapiens_hsa051680.97530100
53Leishmaniasis_Homo sapiens_hsa051400.96921431
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96408302
55Antigen processing and presentation_Homo sapiens_hsa046120.92965341
56Base excision repair_Homo sapiens_hsa034100.90703215
57Systemic lupus erythematosus_Homo sapiens_hsa053220.90658875
58Taste transduction_Homo sapiens_hsa047420.90074855
59Purine metabolism_Homo sapiens_hsa002300.90074153
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90057295
61African trypanosomiasis_Homo sapiens_hsa051430.88871861
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.87825105
63Glutamatergic synapse_Homo sapiens_hsa047240.87604625
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85925707
65Ether lipid metabolism_Homo sapiens_hsa005650.83868281
66Epstein-Barr virus infection_Homo sapiens_hsa051690.81332253
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81065801
68Osteoclast differentiation_Homo sapiens_hsa043800.80517307
69Long-term potentiation_Homo sapiens_hsa047200.80312667
70Prion diseases_Homo sapiens_hsa050200.78681151
71Long-term depression_Homo sapiens_hsa047300.78326507
72Morphine addiction_Homo sapiens_hsa050320.75736010
73Acute myeloid leukemia_Homo sapiens_hsa052210.74370873
74Calcium signaling pathway_Homo sapiens_hsa040200.72749413
75Phagosome_Homo sapiens_hsa041450.72362101
76Amphetamine addiction_Homo sapiens_hsa050310.72283004
77Prolactin signaling pathway_Homo sapiens_hsa049170.72256431
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71739236
79Protein export_Homo sapiens_hsa030600.71566686
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.71550135
81Salivary secretion_Homo sapiens_hsa049700.70192078
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68144412
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67498247
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.64957920
85Circadian entrainment_Homo sapiens_hsa047130.60569791
86Renin secretion_Homo sapiens_hsa049240.60462941
87Viral carcinogenesis_Homo sapiens_hsa052030.59517232
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58367920
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56843255
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56145810
91Chemokine signaling pathway_Homo sapiens_hsa040620.55762673
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55123054
93RNA transport_Homo sapiens_hsa030130.54374834
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51462634
95Pertussis_Homo sapiens_hsa051330.50444258
96Collecting duct acid secretion_Homo sapiens_hsa049660.49226974
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48988413
98Type II diabetes mellitus_Homo sapiens_hsa049300.47789677
99Bladder cancer_Homo sapiens_hsa052190.47249605
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46756510
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46523112
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44315650
103Shigellosis_Homo sapiens_hsa051310.44243317
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43866946
105Arachidonic acid metabolism_Homo sapiens_hsa005900.43691275
106Malaria_Homo sapiens_hsa051440.43639938
107TNF signaling pathway_Homo sapiens_hsa046680.43360475
108Choline metabolism in cancer_Homo sapiens_hsa052310.43139030
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42462188
110VEGF signaling pathway_Homo sapiens_hsa043700.41377246
111GABAergic synapse_Homo sapiens_hsa047270.41183594
112Hepatitis B_Homo sapiens_hsa051610.41178730
113Linoleic acid metabolism_Homo sapiens_hsa005910.40498057
114Tuberculosis_Homo sapiens_hsa051520.39174380
115p53 signaling pathway_Homo sapiens_hsa041150.38501367
116MAPK signaling pathway_Homo sapiens_hsa040100.38230076
117Ras signaling pathway_Homo sapiens_hsa040140.37485867
118Dopaminergic synapse_Homo sapiens_hsa047280.37418074
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.37392037
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36172203
121Influenza A_Homo sapiens_hsa051640.35933207
122Sphingolipid metabolism_Homo sapiens_hsa006000.35635588
123Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35610451
124HTLV-I infection_Homo sapiens_hsa051660.35536148
125mRNA surveillance pathway_Homo sapiens_hsa030150.34527363
126Axon guidance_Homo sapiens_hsa043600.33430614
127Amoebiasis_Homo sapiens_hsa051460.33111357
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.31628269
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31009986
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23171267
131Insulin resistance_Homo sapiens_hsa049310.20873242
132HIF-1 signaling pathway_Homo sapiens_hsa040660.19185766
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.18630883
134Chronic myeloid leukemia_Homo sapiens_hsa052200.15790780
135FoxO signaling pathway_Homo sapiens_hsa040680.14272896
136Complement and coagulation cascades_Homo sapiens_hsa046100.14158824
137Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13846440
138Sulfur metabolism_Homo sapiens_hsa009200.13540880
139Pancreatic cancer_Homo sapiens_hsa052120.13150893
140Small cell lung cancer_Homo sapiens_hsa052220.09307486
141Endocytosis_Homo sapiens_hsa041440.08154695
142Tryptophan metabolism_Homo sapiens_hsa003800.06267737
143Fructose and mannose metabolism_Homo sapiens_hsa000510.05986295
144Dorso-ventral axis formation_Homo sapiens_hsa043200.04549857
145Platelet activation_Homo sapiens_hsa046110.01332714
146Renin-angiotensin system_Homo sapiens_hsa04614-0.0724698
147mTOR signaling pathway_Homo sapiens_hsa04150-0.0678001
148Notch signaling pathway_Homo sapiens_hsa04330-0.0470772
149Galactose metabolism_Homo sapiens_hsa00052-0.0278541
150Prostate cancer_Homo sapiens_hsa05215-0.0072208

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