

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 6.26983706 |
| 2 | regulation of vitamin D biosynthetic process (GO:0060556) | 5.84695187 |
| 3 | regulation of chronic inflammatory response (GO:0002676) | 5.71486115 |
| 4 | neutrophil activation involved in immune response (GO:0002283) | 5.30003090 |
| 5 | negative regulation of interleukin-12 production (GO:0032695) | 5.07121140 |
| 6 | positive regulation of interferon-alpha production (GO:0032727) | 5.04093011 |
| 7 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.95856203 |
| 8 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.95856203 |
| 9 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.95856203 |
| 10 | modulation by symbiont of host immune response (GO:0052553) | 4.95856203 |
| 11 | positive regulation by symbiont of host defense response (GO:0052509) | 4.95856203 |
| 12 | modulation by symbiont of host defense response (GO:0052031) | 4.95856203 |
| 13 | regulation of cytokine secretion involved in immune response (GO:0002739) | 4.80769860 |
| 14 | regulation of interferon-alpha production (GO:0032647) | 4.76952354 |
| 15 | type I interferon signaling pathway (GO:0060337) | 4.73085300 |
| 16 | cellular response to type I interferon (GO:0071357) | 4.73085300 |
| 17 | response to type I interferon (GO:0034340) | 4.68842105 |
| 18 | regulation of vitamin metabolic process (GO:0030656) | 4.66144292 |
| 19 | antigen processing and presentation of endogenous antigen (GO:0019883) | 4.56016108 |
| 20 | granulocyte activation (GO:0036230) | 4.27311020 |
| 21 | regulation of T-helper 1 cell differentiation (GO:0045625) | 4.26954293 |
| 22 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 4.26473625 |
| 23 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.26473625 |
| 24 | regulation of fever generation (GO:0031620) | 4.24807403 |
| 25 | immunoglobulin mediated immune response (GO:0016064) | 4.22883469 |
| 26 | neutrophil activation (GO:0042119) | 4.19872726 |
| 27 | response to peptidoglycan (GO:0032494) | 4.16992872 |
| 28 | regulation of activation of Janus kinase activity (GO:0010533) | 4.13701550 |
| 29 | T-helper 1 type immune response (GO:0042088) | 4.13561853 |
| 30 | regulation of interferon-beta biosynthetic process (GO:0045357) | 4.11178767 |
| 31 | positive regulation of interleukin-12 production (GO:0032735) | 4.00480499 |
| 32 | branching involved in labyrinthine layer morphogenesis (GO:0060670) | 3.97165508 |
| 33 | positive regulation of type 2 immune response (GO:0002830) | 3.96371698 |
| 34 | positive regulation of natural killer cell differentiation (GO:0032825) | 3.95822445 |
| 35 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.92910675 |
| 36 | respiratory burst (GO:0045730) | 3.92513275 |
| 37 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.90140643 |
| 38 | lipopolysaccharide-mediated signaling pathway (GO:0031663) | 3.87660782 |
| 39 | macrophage activation involved in immune response (GO:0002281) | 3.85160816 |
| 40 | positive regulation of gamma-delta T cell activation (GO:0046645) | 3.82156011 |
| 41 | positive regulation of interferon-gamma biosynthetic process (GO:0045078) | 3.81910798 |
| 42 | positive regulation of antigen processing and presentation (GO:0002579) | 3.81626181 |
| 43 | regulation of podosome assembly (GO:0071801) | 3.81405575 |
| 44 | defense response to protozoan (GO:0042832) | 3.78756483 |
| 45 | cellular response to interferon-beta (GO:0035458) | 3.72886152 |
| 46 | regulation of RIG-I signaling pathway (GO:0039535) | 3.70981623 |
| 47 | response to interferon-alpha (GO:0035455) | 3.69966938 |
| 48 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.68486913 |
| 49 | positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725) | 3.68084158 |
| 50 | NIK/NF-kappaB signaling (GO:0038061) | 3.67295564 |
| 51 | myeloid dendritic cell differentiation (GO:0043011) | 3.67108047 |
| 52 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.66611800 |
| 53 | response to host immune response (GO:0052572) | 3.66611800 |
| 54 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.65183815 |
| 55 | positive regulation of interferon-beta production (GO:0032728) | 3.63314798 |
| 56 | negative regulation of viral genome replication (GO:0045071) | 3.61475785 |
| 57 | cellular response to zinc ion (GO:0071294) | 3.59788185 |
| 58 | positive regulation of chemokine biosynthetic process (GO:0045080) | 3.58591729 |
| 59 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.57989684 |
| 60 | germinal center formation (GO:0002467) | 3.57929884 |
| 61 | negative regulation of cytokine production involved in immune response (GO:0002719) | 3.56580951 |
| 62 | hydrogen peroxide biosynthetic process (GO:0050665) | 3.55246729 |
| 63 | cellular response to exogenous dsRNA (GO:0071360) | 3.54640624 |
| 64 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 3.52966701 |
| 65 | cellular response to interferon-alpha (GO:0035457) | 3.48947336 |
| 66 | T cell migration (GO:0072678) | 3.48811635 |
| 67 | positive regulation of T cell cytokine production (GO:0002726) | 3.47244611 |
| 68 | response to muramyl dipeptide (GO:0032495) | 3.45496887 |
| 69 | positive regulation of interleukin-17 production (GO:0032740) | 3.44187061 |
| 70 | myeloid dendritic cell activation (GO:0001773) | 3.41939736 |
| 71 | regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370) | 3.41897294 |
| 72 | positive regulation of NF-kappaB import into nucleus (GO:0042346) | 3.41846280 |
| 73 | regulation of type I interferon-mediated signaling pathway (GO:0060338) | 3.41644355 |
| 74 | negative regulation of interleukin-17 production (GO:0032700) | 3.39503188 |
| 75 | negative regulation of toll-like receptor 4 signaling pathway (GO:0034144) | 3.37308047 |
| 76 | positive regulation of interleukin-8 biosynthetic process (GO:0045416) | 3.35217060 |
| 77 | myeloid cell activation involved in immune response (GO:0002275) | 3.32437158 |
| 78 | regulation of antigen processing and presentation (GO:0002577) | 3.31830909 |
| 79 | regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645) | 3.30057331 |
| 80 | positive regulation of defense response to virus by host (GO:0002230) | 3.28945345 |
| 81 | regulation of interferon-gamma biosynthetic process (GO:0045072) | 3.28206767 |
| 82 | B cell mediated immunity (GO:0019724) | 3.28018838 |
| 83 | dendritic cell differentiation (GO:0097028) | 3.27030191 |
| 84 | positive regulation of T-helper cell differentiation (GO:0045624) | 3.26245006 |
| 85 | negative regulation of nitric oxide biosynthetic process (GO:0045019) | 3.26010267 |
| 86 | regulation of T cell tolerance induction (GO:0002664) | 3.24953376 |
| 87 | regulation of type 2 immune response (GO:0002828) | 3.24419015 |
| 88 | cellular response to interferon-gamma (GO:0071346) | 3.23889959 |
| 89 | regulation of heat generation (GO:0031650) | 3.23558794 |
| 90 | regulation of tumor necrosis factor biosynthetic process (GO:0042534) | 3.23550975 |
| 91 | response to host (GO:0075136) | 3.23281877 |
| 92 | response to host defenses (GO:0052200) | 3.23281877 |
| 93 | response to defenses of other organism involved in symbiotic interaction (GO:0052173) | 3.23281877 |
| 94 | superoxide anion generation (GO:0042554) | 3.23189435 |
| 95 | negative regulation of inflammatory response to antigenic stimulus (GO:0002862) | 3.21424381 |
| 96 | regulation of interleukin-12 production (GO:0032655) | 3.21136848 |
| 97 | regulation of interleukin-17 production (GO:0032660) | 3.21060134 |
| 98 | response to protozoan (GO:0001562) | 3.20601988 |
| 99 | regulation of interleukin-8 biosynthetic process (GO:0045414) | 3.19846099 |
| 100 | cellular response to lipopolysaccharide (GO:0071222) | 3.17607184 |
| 101 | negative regulation of growth of symbiont in host (GO:0044130) | 3.17473184 |
| 102 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 3.17473184 |
| 103 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 3.17473184 |
| 104 | regulation of growth of symbiont in host (GO:0044126) | 3.17473184 |
| 105 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.15133180 |
| 106 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 3.15086912 |
| 107 | eosinophil chemotaxis (GO:0048245) | 3.14577174 |
| 108 | regulation of inflammatory response to antigenic stimulus (GO:0002861) | 3.14270684 |
| 109 | regulation of nitric oxide biosynthetic process (GO:0045428) | 3.13800870 |
| 110 | lymphocyte chemotaxis (GO:0048247) | 3.12847630 |
| 111 | cellular response to virus (GO:0098586) | 3.11675141 |
| 112 | reactive oxygen species biosynthetic process (GO:1903409) | 3.11538301 |
| 113 | positive regulation of nitric oxide biosynthetic process (GO:0045429) | 3.11206221 |
| 114 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 3.11143492 |
| 115 | response to interferon-gamma (GO:0034341) | 3.10791882 |
| 116 | positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770) | 3.10160409 |
| 117 | response to interferon-beta (GO:0035456) | 3.09914538 |
| 118 | positive regulation of response to biotic stimulus (GO:0002833) | 3.09122038 |
| 119 | regulation of membrane protein ectodomain proteolysis (GO:0051043) | 3.09108512 |
| 120 | cellular response to molecule of bacterial origin (GO:0071219) | 3.08935830 |
| 121 | regulation of B cell receptor signaling pathway (GO:0050855) | 3.08081799 |
| 122 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 3.07660711 |
| 123 | regulation of chemokine biosynthetic process (GO:0045073) | 3.06995596 |
| 124 | regulation of hypersensitivity (GO:0002883) | 3.06533311 |
| 125 | negative regulation of amino acid transport (GO:0051956) | 3.06207180 |
| 126 | negative regulation of myeloid cell apoptotic process (GO:0033033) | 3.04499607 |
| 127 | positive regulation of acute inflammatory response (GO:0002675) | 3.02107967 |
| 128 | regulation of immunoglobulin secretion (GO:0051023) | 3.01984706 |
| 129 | positive regulation of monocyte chemotaxis (GO:0090026) | 3.01975216 |
| 130 | regulation of NF-kappaB import into nucleus (GO:0042345) | 3.01854530 |
| 131 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 3.01733469 |
| 132 | regulation of T-helper 1 type immune response (GO:0002825) | 3.01113396 |
| 133 | regulation of syncytium formation by plasma membrane fusion (GO:0060142) | 3.00855591 |
| 134 | regulation of mononuclear cell migration (GO:0071675) | 3.00849180 |
| 135 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 2.99593412 |
| 136 | negative regulation of cell killing (GO:0031342) | 2.99593412 |
| 137 | microglial cell activation (GO:0001774) | 2.98125622 |
| 138 | positive regulation of heat generation (GO:0031652) | 2.97397462 |
| 139 | monocyte chemotaxis (GO:0002548) | 2.97388786 |
| 140 | * natural killer cell mediated immunity (GO:0002228) | 2.96965877 |
| 141 | * natural killer cell mediated cytotoxicity (GO:0042267) | 2.96965877 |
| 142 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.96867153 |
| 143 | regulation of T-helper cell differentiation (GO:0045622) | 2.96741926 |
| 144 | interferon-gamma secretion (GO:0072643) | 2.96725111 |
| 145 | activation of MAPKKK activity (GO:0000185) | 2.96251444 |
| 146 | regulation of CD4-positive, alpha-beta T cell activation (GO:2000514) | 2.96054783 |
| 147 | positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516) | 2.94221502 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 8.45105351 |
| 2 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 7.57508001 |
| 3 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 5.65713237 |
| 4 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 5.52696535 |
| 5 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.91891544 |
| 6 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.76695629 |
| 7 | * IRF8_27001747_Chip-Seq_BMDM_Mouse | 4.43225082 |
| 8 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.75875393 |
| 9 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 3.53004929 |
| 10 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.44141176 |
| 11 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.22833281 |
| 12 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.14122866 |
| 13 | * Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 3.12334012 |
| 14 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 3.11998909 |
| 15 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.10845863 |
| 16 | * STAT4_19710469_ChIP-ChIP_TH1__Mouse | 3.07864664 |
| 17 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 2.58572623 |
| 18 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.57450492 |
| 19 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.00883365 |
| 20 | * MYB_26560356_Chip-Seq_TH2_Human | 1.99318745 |
| 21 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.87062845 |
| 22 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.84106773 |
| 23 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.83477216 |
| 24 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.82076036 |
| 25 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.82035567 |
| 26 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.76597604 |
| 27 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 1.76252729 |
| 28 | * MAF_26560356_Chip-Seq_TH1_Human | 1.70446046 |
| 29 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.67187910 |
| 30 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.65381036 |
| 31 | * MYB_26560356_Chip-Seq_TH1_Human | 1.62938024 |
| 32 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.59176684 |
| 33 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.59136367 |
| 34 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.56995768 |
| 35 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.54668213 |
| 36 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.53962968 |
| 37 | GATA1_22025678_ChIP-Seq_K562_Human | 1.49941714 |
| 38 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.49522876 |
| 39 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.47392820 |
| 40 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.44123302 |
| 41 | SPI1_23127762_ChIP-Seq_K562_Human | 1.44114332 |
| 42 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.44098789 |
| 43 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.39126046 |
| 44 | GATA3_26560356_Chip-Seq_TH2_Human | 1.34444421 |
| 45 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.33666045 |
| 46 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.29467405 |
| 47 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.28648193 |
| 48 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.26443108 |
| 49 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.24372777 |
| 50 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.24325441 |
| 51 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.23961638 |
| 52 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.19642682 |
| 53 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.16423908 |
| 54 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15550888 |
| 55 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.15492745 |
| 56 | * MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.12347686 |
| 57 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.12262186 |
| 58 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.10916799 |
| 59 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.10899177 |
| 60 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.08914502 |
| 61 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.08406175 |
| 62 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.07391561 |
| 63 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.06630811 |
| 64 | STAT1_20625510_ChIP-Seq_HELA_Human | 1.06363298 |
| 65 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.03646839 |
| 66 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.03646839 |
| 67 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.03646839 |
| 68 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.03060529 |
| 69 | UTX_26944678_Chip-Seq_JUKART_Human | 1.01699598 |
| 70 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.00719531 |
| 71 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.00443020 |
| 72 | GATA1_19941826_ChIP-Seq_K562_Human | 0.97921908 |
| 73 | KDM2B_26808549_Chip-Seq_DND41_Human | 0.94656592 |
| 74 | MAF_26560356_Chip-Seq_TH2_Human | 0.91318438 |
| 75 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.91172366 |
| 76 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.89928847 |
| 77 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.88568084 |
| 78 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.87483680 |
| 79 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.85060082 |
| 80 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.84684564 |
| 81 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.84294636 |
| 82 | * LXR_22292898_ChIP-Seq_THP-1_Human | 0.82615690 |
| 83 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.82304197 |
| 84 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 0.81842497 |
| 85 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.80560650 |
| 86 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.80178496 |
| 87 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.79687643 |
| 88 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.76434979 |
| 89 | * PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.73493179 |
| 90 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.72111473 |
| 91 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.71702572 |
| 92 | * EGR1_19032775_ChIP-ChIP_M12_Human | 0.70450891 |
| 93 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.69432783 |
| 94 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.67178869 |
| 95 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.65621275 |
| 96 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.64811629 |
| 97 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.64689145 |
| 98 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.63955057 |
| 99 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.63523702 |
| 100 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.63062038 |
| 101 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 0.62059658 |
| 102 | * GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.61395029 |
| 103 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.61061463 |
| 104 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.61061463 |
| 105 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.61023598 |
| 106 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 0.59221980 |
| 107 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.57842228 |
| 108 | CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.56461709 |
| 109 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.55836248 |
| 110 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.55836248 |
| 111 | MYC_22102868_ChIP-Seq_BL_Human | 0.55259279 |
| 112 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 0.55244019 |
| 113 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.53501595 |
| 114 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.53241724 |
| 115 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.52836857 |
| 116 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.52751290 |
| 117 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.52523121 |
| 118 | * TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.52434335 |
| 119 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.49569545 |
| 120 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.49557543 |
| 121 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.49405684 |
| 122 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 0.49015900 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0001835_abnormal_antigen_presentation | 5.62935093 |
| 2 | MP0009785_altered_susceptibility_to | 4.16139539 |
| 3 | MP0002148_abnormal_hypersensitivity_rea | 3.87383663 |
| 4 | MP0005671_abnormal_response_to | 3.57681271 |
| 5 | MP0000685_abnormal_immune_system | 3.50820162 |
| 6 | MP0003436_decreased_susceptibility_to | 3.49751931 |
| 7 | MP0005387_immune_system_phenotype | 3.47776438 |
| 8 | MP0001790_abnormal_immune_system | 3.47776438 |
| 9 | MP0005000_abnormal_immune_tolerance | 3.39306191 |
| 10 | MP0006082_CNS_inflammation | 3.32310625 |
| 11 | MP0005025_abnormal_response_to | 3.19404206 |
| 12 | MP0002419_abnormal_innate_immunity | 3.01810847 |
| 13 | MP0001800_abnormal_humoral_immune | 3.00311860 |
| 14 | MP0003303_peritoneal_inflammation | 2.99617995 |
| 15 | MP0002452_abnormal_antigen_presenting | 2.95783726 |
| 16 | MP0002723_abnormal_immune_serum | 2.83339835 |
| 17 | MP0004510_myositis | 2.80754437 |
| 18 | MP0003724_increased_susceptibility_to | 2.77059498 |
| 19 | * MP0001819_abnormal_immune_cell | 2.52689185 |
| 20 | * MP0002420_abnormal_adaptive_immunity | 2.46419311 |
| 21 | MP0005451_abnormal_body_composition | 2.34522394 |
| 22 | MP0002139_abnormal_hepatobiliary_system | 2.16916427 |
| 23 | MP0005058_abnormal_lysosome_morphology | 2.14905279 |
| 24 | MP0002006_tumorigenesis | 2.12373608 |
| 25 | MP0004947_skin_inflammation | 2.02142754 |
| 26 | MP0008004_abnormal_stomach_pH | 1.98516607 |
| 27 | MP0001853_heart_inflammation | 1.95173260 |
| 28 | MP0001845_abnormal_inflammatory_respons | 1.89664937 |
| 29 | MP0000716_abnormal_immune_system | 1.88677582 |
| 30 | MP0002405_respiratory_system_inflammati | 1.88139717 |
| 31 | MP0002166_altered_tumor_susceptibility | 1.87792986 |
| 32 | MP0002332_abnormal_exercise_endurance | 1.86867025 |
| 33 | MP0005464_abnormal_platelet_physiology | 1.84087141 |
| 34 | MP0002398_abnormal_bone_marrow | 1.83110967 |
| 35 | MP0009764_decreased_sensitivity_to | 1.82971127 |
| 36 | MP0005310_abnormal_salivary_gland | 1.81761639 |
| 37 | MP0001533_abnormal_skeleton_physiology | 1.80248405 |
| 38 | MP0003448_altered_tumor_morphology | 1.79534437 |
| 39 | MP0010155_abnormal_intestine_physiology | 1.75056864 |
| 40 | MP0000569_abnormal_digit_pigmentation | 1.63075868 |
| 41 | MP0003172_abnormal_lysosome_physiology | 1.61779457 |
| 42 | MP0008469_abnormal_protein_level | 1.61299356 |
| 43 | MP0003195_calcinosis | 1.50351158 |
| 44 | MP0002429_abnormal_blood_cell | 1.47702689 |
| 45 | MP0009333_abnormal_splenocyte_physiolog | 1.46147562 |
| 46 | MP0002138_abnormal_hepatobiliary_system | 1.41515624 |
| 47 | MP0000689_abnormal_spleen_morphology | 1.41268552 |
| 48 | MP0003075_altered_response_to | 1.39793019 |
| 49 | MP0006054_spinal_hemorrhage | 1.37795105 |
| 50 | MP0000858_altered_metastatic_potential | 1.36561303 |
| 51 | MP0003763_abnormal_thymus_physiology | 1.34835346 |
| 52 | MP0002998_abnormal_bone_remodeling | 1.31892923 |
| 53 | MP0002722_abnormal_immune_system | 1.31690614 |
| 54 | MP0004782_abnormal_surfactant_physiolog | 1.20521945 |
| 55 | MP0005397_hematopoietic_system_phenotyp | 1.17079294 |
| 56 | MP0001545_abnormal_hematopoietic_system | 1.17079294 |
| 57 | MP0009278_abnormal_bone_marrow | 1.15777934 |
| 58 | MP0002163_abnormal_gland_morphology | 1.15584531 |
| 59 | MP0000343_altered_response_to | 1.15116069 |
| 60 | MP0002277_abnormal_respiratory_mucosa | 1.14198217 |
| 61 | MP0005166_decreased_susceptibility_to | 1.11482035 |
| 62 | MP0010307_abnormal_tumor_latency | 1.10478231 |
| 63 | MP0003806_abnormal_nucleotide_metabolis | 1.10154378 |
| 64 | MP0002254_reproductive_system_inflammat | 1.07816190 |
| 65 | MP0000604_amyloidosis | 1.06781719 |
| 66 | MP0001348_abnormal_lacrimal_gland | 1.06360834 |
| 67 | MP0003646_muscle_fatigue | 1.02318461 |
| 68 | MP0003191_abnormal_cellular_cholesterol | 1.01288588 |
| 69 | MP0001501_abnormal_sleep_pattern | 1.01077322 |
| 70 | MP0003656_abnormal_erythrocyte_physiolo | 1.00055505 |
| 71 | MP0009763_increased_sensitivity_to | 0.95209896 |
| 72 | MP0003300_gastrointestinal_ulcer | 0.93825249 |
| 73 | MP0009840_abnormal_foam_cell | 0.92814158 |
| 74 | MP0005076_abnormal_cell_differentiation | 0.92781217 |
| 75 | MP0001542_abnormal_bone_strength | 0.90143730 |
| 76 | MP0001663_abnormal_digestive_system | 0.88445077 |
| 77 | MP0002933_joint_inflammation | 0.87313532 |
| 78 | MP0005174_abnormal_tail_pigmentation | 0.86179991 |
| 79 | MP0003186_abnormal_redox_activity | 0.84858268 |
| 80 | MP0005165_increased_susceptibility_to | 0.82975883 |
| 81 | MP0001873_stomach_inflammation | 0.80196879 |
| 82 | MP0000703_abnormal_thymus_morphology | 0.79504897 |
| 83 | MP0003183_abnormal_peptide_metabolism | 0.77900703 |
| 84 | MP0005390_skeleton_phenotype | 0.77624219 |
| 85 | MP0005164_abnormal_response_to | 0.76992098 |
| 86 | MP0005167_abnormal_blood-brain_barrier | 0.76907384 |
| 87 | MP0003091_abnormal_cell_migration | 0.76164886 |
| 88 | MP0003453_abnormal_keratinocyte_physiol | 0.74165374 |
| 89 | MP0008874_decreased_physiological_sensi | 0.73622924 |
| 90 | MP0005535_abnormal_body_temperature | 0.73055081 |
| 91 | MP0000371_diluted_coat_color | 0.71700593 |
| 92 | MP0003690_abnormal_glial_cell | 0.69490999 |
| 93 | MP0004883_abnormal_blood_vessel | 0.69179182 |
| 94 | MP0003045_fibrosis | 0.69065650 |
| 95 | MP0005647_abnormal_sex_gland | 0.67499181 |
| 96 | MP0000920_abnormal_myelination | 0.66761241 |
| 97 | MP0005266_abnormal_metabolism | 0.66156828 |
| 98 | MP0002136_abnormal_kidney_physiology | 0.65744452 |
| 99 | MP0000249_abnormal_blood_vessel | 0.65628734 |
| 100 | MP0001346_abnormal_lacrimal_gland | 0.65479246 |
| 101 | MP0004808_abnormal_hematopoietic_stem | 0.63722470 |
| 102 | MP0000015_abnormal_ear_pigmentation | 0.62997118 |
| 103 | MP0003866_abnormal_defecation | 0.61736892 |
| 104 | MP0003828_pulmonary_edema | 0.60872544 |
| 105 | MP0002693_abnormal_pancreas_physiology | 0.60643255 |
| 106 | MP0001851_eye_inflammation | 0.59419216 |
| 107 | MP0001881_abnormal_mammary_gland | 0.59406904 |
| 108 | MP0004858_abnormal_nervous_system | 0.58972646 |
| 109 | MP0005666_abnormal_adipose_tissue | 0.58607462 |
| 110 | MP0005023_abnormal_wound_healing | 0.58499278 |
| 111 | MP0008260_abnormal_autophagy | 0.58456498 |
| 112 | MP0010352_gastrointestinal_tract_polyps | 0.57842866 |
| 113 | MP0003566_abnormal_cell_adhesion | 0.53607550 |
| 114 | MP0002019_abnormal_tumor_incidence | 0.52739961 |
| 115 | MP0005381_digestive/alimentary_phenotyp | 0.51145963 |
| 116 | MP0005379_endocrine/exocrine_gland_phen | 0.49506367 |
| 117 | MP0003795_abnormal_bone_structure | 0.49276960 |
| 118 | MP0010386_abnormal_urinary_bladder | 0.48522956 |
| 119 | MP0000490_abnormal_crypts_of | 0.48370894 |
| 120 | MP0000609_abnormal_liver_physiology | 0.47467276 |
| 121 | MP0001764_abnormal_homeostasis | 0.46892580 |
| 122 | MP0005319_abnormal_enzyme/_coenzyme | 0.46801483 |
| 123 | MP0008057_abnormal_DNA_replication | 0.45035635 |
| 124 | MP0009765_abnormal_xenobiotic_induced | 0.44016883 |
| 125 | MP0000627_abnormal_mammary_gland | 0.43727916 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent abscess formation (HP:0002722) | 6.81257539 |
| 2 | Eczematoid dermatitis (HP:0000976) | 6.80110610 |
| 3 | Recurrent bacterial skin infections (HP:0005406) | 6.42435099 |
| 4 | Recurrent gram-negative bacterial infections (HP:0005420) | 5.55810147 |
| 5 | Autoimmune thrombocytopenia (HP:0001973) | 5.06567492 |
| 6 | Mediastinal lymphadenopathy (HP:0100721) | 5.00062169 |
| 7 | Abnormality of macrophages (HP:0004311) | 4.98117966 |
| 8 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.76127532 |
| 9 | Increased IgM level (HP:0003496) | 4.75148612 |
| 10 | Recurrent fungal infections (HP:0002841) | 4.33270814 |
| 11 | Recurrent viral infections (HP:0004429) | 4.28338163 |
| 12 | Vasculitis (HP:0002633) | 4.22275178 |
| 13 | Recurrent skin infections (HP:0001581) | 4.17214573 |
| 14 | Myositis (HP:0100614) | 4.16978728 |
| 15 | Stomatitis (HP:0010280) | 4.13894510 |
| 16 | Retrobulbar optic neuritis (HP:0100654) | 4.13192866 |
| 17 | Optic neuritis (HP:0100653) | 4.13192866 |
| 18 | Orchitis (HP:0100796) | 3.98840272 |
| 19 | Gingivitis (HP:0000230) | 3.90962477 |
| 20 | Obstructive lung disease (HP:0006536) | 3.85158411 |
| 21 | Chronic obstructive pulmonary disease (HP:0006510) | 3.85158411 |
| 22 | Dysostosis multiplex (HP:0000943) | 3.79733316 |
| 23 | Chronic otitis media (HP:0000389) | 3.69489083 |
| 24 | Cellulitis (HP:0100658) | 3.54516890 |
| 25 | Increased cerebral lipofuscin (HP:0011813) | 3.54127562 |
| 26 | Basal ganglia calcification (HP:0002135) | 3.48127200 |
| 27 | Increased neuronal autofluorescent lipopigment (HP:0002074) | 3.41271747 |
| 28 | Vacuolated lymphocytes (HP:0001922) | 3.40674143 |
| 29 | Gangrene (HP:0100758) | 3.38301964 |
| 30 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.33376167 |
| 31 | Recurrent cutaneous fungal infections (HP:0011370) | 3.33376167 |
| 32 | Meningitis (HP:0001287) | 3.30955058 |
| 33 | Gastrointestinal infarctions (HP:0005244) | 3.27706900 |
| 34 | Hypergammaglobulinemia (HP:0010702) | 3.23841277 |
| 35 | Interstitial pulmonary disease (HP:0006530) | 3.22967934 |
| 36 | Nuclear cataract (HP:0100018) | 3.22133911 |
| 37 | Mutism (HP:0002300) | 3.19538510 |
| 38 | Recurrent pneumonia (HP:0006532) | 3.16552561 |
| 39 | Pulmonary infiltrates (HP:0002113) | 3.12441813 |
| 40 | Recurrent bronchitis (HP:0002837) | 3.12185950 |
| 41 | Periodontitis (HP:0000704) | 3.10877507 |
| 42 | Abnormality of T cell number (HP:0011839) | 3.06777808 |
| 43 | Agammaglobulinemia (HP:0004432) | 3.06686085 |
| 44 | Parakeratosis (HP:0001036) | 2.96455387 |
| 45 | Pustule (HP:0200039) | 2.94817588 |
| 46 | Nasal polyposis (HP:0100582) | 2.90159932 |
| 47 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.86174898 |
| 48 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.86174898 |
| 49 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.86174898 |
| 50 | Autoimmune hemolytic anemia (HP:0001890) | 2.85535494 |
| 51 | Osteomyelitis (HP:0002754) | 2.84956780 |
| 52 | Tetraparesis (HP:0002273) | 2.82145704 |
| 53 | Recurrent lower respiratory tract infections (HP:0002783) | 2.80294217 |
| 54 | Hemoptysis (HP:0002105) | 2.79681149 |
| 55 | Prostate neoplasm (HP:0100787) | 2.79288642 |
| 56 | Encephalitis (HP:0002383) | 2.77308111 |
| 57 | Leukocytosis (HP:0001974) | 2.74626666 |
| 58 | Glomerulonephritis (HP:0000099) | 2.73444375 |
| 59 | Abnormality of glycolipid metabolism (HP:0010969) | 2.73191367 |
| 60 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.73191367 |
| 61 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.73191367 |
| 62 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.71525112 |
| 63 | Mucopolysacchariduria (HP:0008155) | 2.71525112 |
| 64 | Urticaria (HP:0001025) | 2.70600826 |
| 65 | Systemic lupus erythematosus (HP:0002725) | 2.69865917 |
| 66 | Thick nail (HP:0001805) | 2.67849998 |
| 67 | Arterial thrombosis (HP:0004420) | 2.64918345 |
| 68 | T lymphocytopenia (HP:0005403) | 2.62974845 |
| 69 | Eosinophilia (HP:0001880) | 2.62952977 |
| 70 | Increased serum ferritin (HP:0003281) | 2.61750687 |
| 71 | Polyneuropathy (HP:0001271) | 2.59401987 |
| 72 | Neurofibrillary tangles (HP:0002185) | 2.53853818 |
| 73 | Loss of speech (HP:0002371) | 2.53709442 |
| 74 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.51623636 |
| 75 | Chronic sinusitis (HP:0011109) | 2.48431690 |
| 76 | Premature loss of primary teeth (HP:0006323) | 2.48318851 |
| 77 | Apathy (HP:0000741) | 2.46032384 |
| 78 | Colitis (HP:0002583) | 2.45764928 |
| 79 | Abnormality of B cell number (HP:0010975) | 2.44050520 |
| 80 | Abnormality of the nasal mucosa (HP:0000433) | 2.43753219 |
| 81 | Abnormality of T cells (HP:0002843) | 2.42533691 |
| 82 | Gingival bleeding (HP:0000225) | 2.42133944 |
| 83 | Porencephaly (HP:0002132) | 2.41405335 |
| 84 | IgG deficiency (HP:0004315) | 2.40567976 |
| 85 | Progressive neurologic deterioration (HP:0002344) | 2.37546696 |
| 86 | Keratoconjunctivitis sicca (HP:0001097) | 2.36183221 |
| 87 | Myocardial infarction (HP:0001658) | 2.34192237 |
| 88 | Diminished motivation (HP:0000745) | 2.33933055 |
| 89 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 2.33890371 |
| 90 | Disinhibition (HP:0000734) | 2.33598195 |
| 91 | Axonal loss (HP:0003447) | 2.32942074 |
| 92 | Thyroiditis (HP:0100646) | 2.31255047 |
| 93 | Gastrointestinal stroma tumor (HP:0100723) | 2.29959466 |
| 94 | Nausea (HP:0002018) | 2.27432791 |
| 95 | Poor head control (HP:0002421) | 2.27385240 |
| 96 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.27123817 |
| 97 | Abnormality of eosinophils (HP:0001879) | 2.26361956 |
| 98 | Emphysema (HP:0002097) | 2.26043892 |
| 99 | B lymphocytopenia (HP:0010976) | 2.25758468 |
| 100 | Joint swelling (HP:0001386) | 2.25226831 |
| 101 | IgA deficiency (HP:0002720) | 2.23630457 |
| 102 | Inflammation of the large intestine (HP:0002037) | 2.23206006 |
| 103 | Granulocytopenia (HP:0001913) | 2.20317286 |
| 104 | Vertigo (HP:0002321) | 2.19943343 |
| 105 | Sepsis (HP:0100806) | 2.19897975 |
| 106 | Purpura (HP:0000979) | 2.18587546 |
| 107 | Abnormality of T cell physiology (HP:0011840) | 2.18509739 |
| 108 | Inappropriate behavior (HP:0000719) | 2.17990551 |
| 109 | Amyloidosis (HP:0011034) | 2.17758971 |
| 110 | Keratoconjunctivitis (HP:0001096) | 2.17520276 |
| 111 | Lymphopenia (HP:0001888) | 2.16690954 |
| 112 | Metaphyseal irregularity (HP:0003025) | 2.16563449 |
| 113 | Pulmonary embolism (HP:0002204) | 2.16387195 |
| 114 | Memory impairment (HP:0002354) | 2.14561030 |
| 115 | Keratitis (HP:0000491) | 2.12958917 |
| 116 | Anorexia (HP:0002039) | 2.12119452 |
| 117 | Arthralgia (HP:0002829) | 2.11076455 |
| 118 | Combined immunodeficiency (HP:0005387) | 2.09588378 |
| 119 | Gastrointestinal inflammation (HP:0004386) | 2.07990433 |
| 120 | Skin ulcer (HP:0200042) | 2.07789090 |
| 121 | Acne (HP:0001061) | 2.07545571 |
| 122 | Abnormality of iron homeostasis (HP:0011031) | 2.06069979 |
| 123 | Recurrent sinusitis (HP:0011108) | 2.05134002 |
| 124 | Glomerulopathy (HP:0100820) | 2.04225547 |
| 125 | Abnormality of the pericardium (HP:0001697) | 2.03840159 |
| 126 | Abnormality of the pleura (HP:0002103) | 2.02642761 |
| 127 | Abnormality of the endocardium (HP:0004306) | 2.02507729 |
| 128 | Increased IgE level (HP:0003212) | 2.00367751 |
| 129 | Hematochezia (HP:0002573) | 1.99609320 |
| 130 | Severe combined immunodeficiency (HP:0004430) | 1.99183218 |
| 131 | Agnosia (HP:0010524) | 1.98929164 |
| 132 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 1.97130007 |
| 133 | Abnormality of the prostate (HP:0008775) | 1.96410452 |
| 134 | Osteolytic defects of the hand bones (HP:0009699) | 1.96148321 |
| 135 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 1.96148321 |
| 136 | Neuronal loss in central nervous system (HP:0002529) | 1.95958449 |
| 137 | Complement deficiency (HP:0004431) | 1.93315998 |
| 138 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 1.91332446 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP3K14 | 5.36217257 |
| 2 | TBK1 | 3.84943606 |
| 3 | TYK2 | 3.80716535 |
| 4 | PBK | 3.74909165 |
| 5 | RIPK4 | 3.66975541 |
| 6 | BLK | 3.28527509 |
| 7 | IKBKE | 3.22131825 |
| 8 | JAK3 | 3.08759113 |
| 9 | IRAK4 | 3.04578594 |
| 10 | MAP4K1 | 2.91618791 |
| 11 | TAOK2 | 2.89039514 |
| 12 | IKBKB | 2.78726750 |
| 13 | JAK1 | 2.64976642 |
| 14 | DDR2 | 2.64905854 |
| 15 | PRPF4B | 2.62068468 |
| 16 | MAP3K13 | 2.61784226 |
| 17 | IRAK3 | 2.33065948 |
| 18 | TXK | 2.29963093 |
| 19 | KIT | 2.16417602 |
| 20 | CHUK | 1.82539253 |
| 21 | PIM2 | 1.81064336 |
| 22 | SYK | 1.75401094 |
| 23 | TAOK1 | 1.72611515 |
| 24 | FGFR4 | 1.54982848 |
| 25 | ERN1 | 1.51322001 |
| 26 | CDC42BPA | 1.49861491 |
| 27 | NEK9 | 1.46988473 |
| 28 | CSK | 1.42566965 |
| 29 | ZAP70 | 1.41990538 |
| 30 | BMPR2 | 1.39387191 |
| 31 | TAOK3 | 1.34849502 |
| 32 | MAP3K3 | 1.34595594 |
| 33 | TGFBR2 | 1.26818893 |
| 34 | HCK | 1.26772806 |
| 35 | CSF1R | 1.24517578 |
| 36 | FGFR3 | 1.24430533 |
| 37 | LYN | 1.19895332 |
| 38 | LCK | 1.18509233 |
| 39 | PIM1 | 1.17662082 |
| 40 | STK4 | 1.16695164 |
| 41 | MST4 | 1.13744009 |
| 42 | RPS6KA4 | 1.11941646 |
| 43 | EPHB1 | 1.10644750 |
| 44 | NME2 | 1.08769414 |
| 45 | BTK | 1.07015895 |
| 46 | EPHA3 | 1.05868360 |
| 47 | EIF2AK2 | 1.03667513 |
| 48 | JAK2 | 1.02914928 |
| 49 | BMX | 0.94694024 |
| 50 | MAP2K3 | 0.92047243 |
| 51 | TYRO3 | 0.89905291 |
| 52 | IRAK1 | 0.87657741 |
| 53 | ARAF | 0.86484986 |
| 54 | ACVR1B | 0.83986217 |
| 55 | TEC | 0.82817787 |
| 56 | MARK3 | 0.82657116 |
| 57 | MAP3K10 | 0.81748385 |
| 58 | SIK3 | 0.78710632 |
| 59 | MATK | 0.77345141 |
| 60 | PRKCQ | 0.76106753 |
| 61 | ABL2 | 0.75879433 |
| 62 | FGR | 0.71863873 |
| 63 | MAP3K5 | 0.70524928 |
| 64 | PRKCD | 0.68664871 |
| 65 | FES | 0.67882781 |
| 66 | HIPK2 | 0.66569645 |
| 67 | MST1R | 0.65804191 |
| 68 | ITK | 0.64776087 |
| 69 | LATS2 | 0.64309519 |
| 70 | ABL1 | 0.62929354 |
| 71 | TRPM7 | 0.61766494 |
| 72 | STK10 | 0.61410134 |
| 73 | DYRK3 | 0.60502948 |
| 74 | SIK2 | 0.58780763 |
| 75 | YES1 | 0.57920910 |
| 76 | EGFR | 0.53035423 |
| 77 | PKN1 | 0.52636951 |
| 78 | NLK | 0.52151275 |
| 79 | IRAK2 | 0.51657594 |
| 80 | MAP2K6 | 0.51617252 |
| 81 | ERBB3 | 0.50576130 |
| 82 | NUAK1 | 0.48194770 |
| 83 | MAPK4 | 0.47144214 |
| 84 | DAPK2 | 0.42802705 |
| 85 | GRK7 | 0.40387072 |
| 86 | TESK2 | 0.39218990 |
| 87 | GRK6 | 0.38101823 |
| 88 | STK3 | 0.36887609 |
| 89 | RPS6KA5 | 0.36691635 |
| 90 | MAPKAPK2 | 0.36457612 |
| 91 | CLK1 | 0.36287867 |
| 92 | PDGFRA | 0.35993999 |
| 93 | LRRK2 | 0.35472766 |
| 94 | ADRBK2 | 0.34928402 |
| 95 | MAPK7 | 0.34453335 |
| 96 | CDK12 | 0.31644942 |
| 97 | MOS | 0.30010251 |
| 98 | DAPK3 | 0.26252669 |
| 99 | RIPK1 | 0.24252065 |
| 100 | MAP3K1 | 0.24107942 |
| 101 | FYN | 0.23999082 |
| 102 | TESK1 | 0.23573920 |
| 103 | DYRK1B | 0.22603210 |
| 104 | PDK1 | 0.22336023 |
| 105 | BCR | 0.20857454 |
| 106 | BMPR1B | 0.20154967 |
| 107 | MAP3K11 | 0.19757194 |
| 108 | INSR | 0.19599391 |
| 109 | TLK1 | 0.19554089 |
| 110 | RPS6KA1 | 0.18862259 |
| 111 | RPS6KL1 | 0.18155872 |
| 112 | RPS6KC1 | 0.18155872 |
| 113 | IGF1R | 0.17192471 |
| 114 | STK24 | 0.16889439 |
| 115 | PDGFRB | 0.16819301 |
| 116 | RAF1 | 0.16673633 |
| 117 | CDK4 | 0.16654880 |
| 118 | PTK6 | 0.15510282 |
| 119 | CDK6 | 0.15481577 |
| 120 | RPS6KA6 | 0.14698735 |
| 121 | TNK2 | 0.14241127 |
| 122 | MAPK3 | 0.12856541 |
| 123 | MAP3K12 | 0.12373824 |
| 124 | PDPK1 | 0.12103001 |
| 125 | EIF2AK1 | 0.11570279 |
| 126 | MAPK11 | 0.10932611 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Graft-versus-host disease_Homo sapiens_hsa05332 | 4.02478403 |
| 2 | Allograft rejection_Homo sapiens_hsa05330 | 3.73316617 |
| 3 | Leishmaniasis_Homo sapiens_hsa05140 | 3.12704162 |
| 4 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 2.94503643 |
| 5 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.81042521 |
| 6 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.80837986 |
| 7 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.75680390 |
| 8 | Measles_Homo sapiens_hsa05162 | 2.45231400 |
| 9 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.44540286 |
| 10 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 2.42353186 |
| 11 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.40534640 |
| 12 | Legionellosis_Homo sapiens_hsa05134 | 2.21200419 |
| 13 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.15640774 |
| 14 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.12595106 |
| 15 | Influenza A_Homo sapiens_hsa05164 | 2.09330332 |
| 16 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 2.05100448 |
| 17 | Pertussis_Homo sapiens_hsa05133 | 2.04840119 |
| 18 | Asthma_Homo sapiens_hsa05310 | 2.04000795 |
| 19 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 2.03680766 |
| 20 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.02711434 |
| 21 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.97630742 |
| 22 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.96659927 |
| 23 | Malaria_Homo sapiens_hsa05144 | 1.96016030 |
| 24 | Tuberculosis_Homo sapiens_hsa05152 | 1.95571865 |
| 25 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.85062754 |
| 26 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.78848145 |
| 27 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.73572762 |
| 28 | African trypanosomiasis_Homo sapiens_hsa05143 | 1.63386981 |
| 29 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.63218403 |
| 30 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 1.61394910 |
| 31 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.50380773 |
| 32 | Viral myocarditis_Homo sapiens_hsa05416 | 1.48725921 |
| 33 | Salmonella infection_Homo sapiens_hsa05132 | 1.48414421 |
| 34 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.46593049 |
| 35 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.45364923 |
| 36 | Apoptosis_Homo sapiens_hsa04210 | 1.42083391 |
| 37 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.38460988 |
| 38 | Lysosome_Homo sapiens_hsa04142 | 1.37616616 |
| 39 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 1.30358133 |
| 40 | Phagosome_Homo sapiens_hsa04145 | 1.25164847 |
| 41 | Shigellosis_Homo sapiens_hsa05131 | 1.16584760 |
| 42 | Hepatitis C_Homo sapiens_hsa05160 | 1.14687352 |
| 43 | Hepatitis B_Homo sapiens_hsa05161 | 1.12272819 |
| 44 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.08770778 |
| 45 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.05918553 |
| 46 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.96326424 |
| 47 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.86444014 |
| 48 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.81373947 |
| 49 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.79133399 |
| 50 | Other glycan degradation_Homo sapiens_hsa00511 | 0.76307221 |
| 51 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.74080626 |
| 52 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.70886182 |
| 53 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.70642203 |
| 54 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.69774965 |
| 55 | Amoebiasis_Homo sapiens_hsa05146 | 0.66424565 |
| 56 | Bladder cancer_Homo sapiens_hsa05219 | 0.66154030 |
| 57 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.57120130 |
| 58 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.55231527 |
| 59 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.54983330 |
| 60 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.53879244 |
| 61 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.52496346 |
| 62 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.50979813 |
| 63 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.50618593 |
| 64 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.50602349 |
| 65 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.50529036 |
| 66 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.48009205 |
| 67 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.47053379 |
| 68 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.46624615 |
| 69 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.46127053 |
| 70 | Prion diseases_Homo sapiens_hsa05020 | 0.45564669 |
| 71 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.44624579 |
| 72 | Proteasome_Homo sapiens_hsa03050 | 0.43120263 |
| 73 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.42610808 |
| 74 | Platelet activation_Homo sapiens_hsa04611 | 0.42554983 |
| 75 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.41859822 |
| 76 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.40971396 |
| 77 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.39558899 |
| 78 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.39445389 |
| 79 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.37048104 |
| 80 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.36146305 |
| 81 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.36052840 |
| 82 | HTLV-I infection_Homo sapiens_hsa05166 | 0.34512481 |
| 83 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.32372783 |
| 84 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.30806939 |
| 85 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.26943159 |
| 86 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.24667894 |
| 87 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.23630884 |
| 88 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.23416812 |
| 89 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.23025607 |
| 90 | Mineral absorption_Homo sapiens_hsa04978 | 0.18363151 |
| 91 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.18344627 |
| 92 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.17780110 |
| 93 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.15320359 |
| 94 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.14581762 |
| 95 | Endocytosis_Homo sapiens_hsa04144 | 0.13946556 |
| 96 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.13405025 |
| 97 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.12773511 |
| 98 | Insulin resistance_Homo sapiens_hsa04931 | 0.12452854 |
| 99 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.12361495 |
| 100 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.12291638 |
| 101 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.10559328 |
| 102 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.10164521 |
| 103 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.08690438 |
| 104 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.07409104 |
| 105 | Galactose metabolism_Homo sapiens_hsa00052 | 0.07160492 |
| 106 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.06171046 |
| 107 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.05256554 |
| 108 | Prostate cancer_Homo sapiens_hsa05215 | 0.04609450 |
| 109 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.04290718 |
| 110 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.02725535 |
| 111 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.01734467 |

