SLAMF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.26983706
2regulation of vitamin D biosynthetic process (GO:0060556)5.84695187
3regulation of chronic inflammatory response (GO:0002676)5.71486115
4neutrophil activation involved in immune response (GO:0002283)5.30003090
5negative regulation of interleukin-12 production (GO:0032695)5.07121140
6positive regulation of interferon-alpha production (GO:0032727)5.04093011
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.95856203
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.95856203
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.95856203
10modulation by symbiont of host immune response (GO:0052553)4.95856203
11positive regulation by symbiont of host defense response (GO:0052509)4.95856203
12modulation by symbiont of host defense response (GO:0052031)4.95856203
13regulation of cytokine secretion involved in immune response (GO:0002739)4.80769860
14regulation of interferon-alpha production (GO:0032647)4.76952354
15type I interferon signaling pathway (GO:0060337)4.73085300
16cellular response to type I interferon (GO:0071357)4.73085300
17response to type I interferon (GO:0034340)4.68842105
18regulation of vitamin metabolic process (GO:0030656)4.66144292
19antigen processing and presentation of endogenous antigen (GO:0019883)4.56016108
20granulocyte activation (GO:0036230)4.27311020
21regulation of T-helper 1 cell differentiation (GO:0045625)4.26954293
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26473625
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.26473625
24regulation of fever generation (GO:0031620)4.24807403
25immunoglobulin mediated immune response (GO:0016064)4.22883469
26neutrophil activation (GO:0042119)4.19872726
27response to peptidoglycan (GO:0032494)4.16992872
28regulation of activation of Janus kinase activity (GO:0010533)4.13701550
29T-helper 1 type immune response (GO:0042088)4.13561853
30regulation of interferon-beta biosynthetic process (GO:0045357)4.11178767
31positive regulation of interleukin-12 production (GO:0032735)4.00480499
32branching involved in labyrinthine layer morphogenesis (GO:0060670)3.97165508
33positive regulation of type 2 immune response (GO:0002830)3.96371698
34positive regulation of natural killer cell differentiation (GO:0032825)3.95822445
35interferon-gamma-mediated signaling pathway (GO:0060333)3.92910675
36respiratory burst (GO:0045730)3.92513275
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.90140643
38lipopolysaccharide-mediated signaling pathway (GO:0031663)3.87660782
39macrophage activation involved in immune response (GO:0002281)3.85160816
40positive regulation of gamma-delta T cell activation (GO:0046645)3.82156011
41positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.81910798
42positive regulation of antigen processing and presentation (GO:0002579)3.81626181
43regulation of podosome assembly (GO:0071801)3.81405575
44defense response to protozoan (GO:0042832)3.78756483
45cellular response to interferon-beta (GO:0035458)3.72886152
46regulation of RIG-I signaling pathway (GO:0039535)3.70981623
47response to interferon-alpha (GO:0035455)3.69966938
48regulation of alpha-beta T cell proliferation (GO:0046640)3.68486913
49positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.68084158
50NIK/NF-kappaB signaling (GO:0038061)3.67295564
51myeloid dendritic cell differentiation (GO:0043011)3.67108047
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.66611800
53response to host immune response (GO:0052572)3.66611800
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.65183815
55positive regulation of interferon-beta production (GO:0032728)3.63314798
56negative regulation of viral genome replication (GO:0045071)3.61475785
57cellular response to zinc ion (GO:0071294)3.59788185
58positive regulation of chemokine biosynthetic process (GO:0045080)3.58591729
59positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.57989684
60germinal center formation (GO:0002467)3.57929884
61negative regulation of cytokine production involved in immune response (GO:0002719)3.56580951
62hydrogen peroxide biosynthetic process (GO:0050665)3.55246729
63cellular response to exogenous dsRNA (GO:0071360)3.54640624
64regulation of interleukin-12 biosynthetic process (GO:0045075)3.52966701
65cellular response to interferon-alpha (GO:0035457)3.48947336
66T cell migration (GO:0072678)3.48811635
67positive regulation of T cell cytokine production (GO:0002726)3.47244611
68response to muramyl dipeptide (GO:0032495)3.45496887
69positive regulation of interleukin-17 production (GO:0032740)3.44187061
70myeloid dendritic cell activation (GO:0001773)3.41939736
71regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.41897294
72positive regulation of NF-kappaB import into nucleus (GO:0042346)3.41846280
73regulation of type I interferon-mediated signaling pathway (GO:0060338)3.41644355
74negative regulation of interleukin-17 production (GO:0032700)3.39503188
75negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.37308047
76positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.35217060
77myeloid cell activation involved in immune response (GO:0002275)3.32437158
78regulation of antigen processing and presentation (GO:0002577)3.31830909
79regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.30057331
80positive regulation of defense response to virus by host (GO:0002230)3.28945345
81regulation of interferon-gamma biosynthetic process (GO:0045072)3.28206767
82B cell mediated immunity (GO:0019724)3.28018838
83dendritic cell differentiation (GO:0097028)3.27030191
84positive regulation of T-helper cell differentiation (GO:0045624)3.26245006
85negative regulation of nitric oxide biosynthetic process (GO:0045019)3.26010267
86regulation of T cell tolerance induction (GO:0002664)3.24953376
87regulation of type 2 immune response (GO:0002828)3.24419015
88cellular response to interferon-gamma (GO:0071346)3.23889959
89regulation of heat generation (GO:0031650)3.23558794
90regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.23550975
91response to host (GO:0075136)3.23281877
92response to host defenses (GO:0052200)3.23281877
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23281877
94superoxide anion generation (GO:0042554)3.23189435
95negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.21424381
96regulation of interleukin-12 production (GO:0032655)3.21136848
97regulation of interleukin-17 production (GO:0032660)3.21060134
98response to protozoan (GO:0001562)3.20601988
99regulation of interleukin-8 biosynthetic process (GO:0045414)3.19846099
100cellular response to lipopolysaccharide (GO:0071222)3.17607184
101negative regulation of growth of symbiont in host (GO:0044130)3.17473184
102negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.17473184
103modulation of growth of symbiont involved in interaction with host (GO:0044144)3.17473184
104regulation of growth of symbiont in host (GO:0044126)3.17473184
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.15133180
106positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.15086912
107eosinophil chemotaxis (GO:0048245)3.14577174
108regulation of inflammatory response to antigenic stimulus (GO:0002861)3.14270684
109regulation of nitric oxide biosynthetic process (GO:0045428)3.13800870
110lymphocyte chemotaxis (GO:0048247)3.12847630
111cellular response to virus (GO:0098586)3.11675141
112reactive oxygen species biosynthetic process (GO:1903409)3.11538301
113positive regulation of nitric oxide biosynthetic process (GO:0045429)3.11206221
114positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.11143492
115response to interferon-gamma (GO:0034341)3.10791882
116positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.10160409
117response to interferon-beta (GO:0035456)3.09914538
118positive regulation of response to biotic stimulus (GO:0002833)3.09122038
119regulation of membrane protein ectodomain proteolysis (GO:0051043)3.09108512
120cellular response to molecule of bacterial origin (GO:0071219)3.08935830
121regulation of B cell receptor signaling pathway (GO:0050855)3.08081799
122positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.07660711
123regulation of chemokine biosynthetic process (GO:0045073)3.06995596
124regulation of hypersensitivity (GO:0002883)3.06533311
125negative regulation of amino acid transport (GO:0051956)3.06207180
126negative regulation of myeloid cell apoptotic process (GO:0033033)3.04499607
127positive regulation of acute inflammatory response (GO:0002675)3.02107967
128regulation of immunoglobulin secretion (GO:0051023)3.01984706
129positive regulation of monocyte chemotaxis (GO:0090026)3.01975216
130regulation of NF-kappaB import into nucleus (GO:0042345)3.01854530
131regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.01733469
132regulation of T-helper 1 type immune response (GO:0002825)3.01113396
133regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.00855591
134regulation of mononuclear cell migration (GO:0071675)3.00849180
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.99593412
136negative regulation of cell killing (GO:0031342)2.99593412
137microglial cell activation (GO:0001774)2.98125622
138positive regulation of heat generation (GO:0031652)2.97397462
139monocyte chemotaxis (GO:0002548)2.97388786
140* natural killer cell mediated immunity (GO:0002228)2.96965877
141* natural killer cell mediated cytotoxicity (GO:0042267)2.96965877
142regulation of T-helper 2 cell differentiation (GO:0045628)2.96867153
143regulation of T-helper cell differentiation (GO:0045622)2.96741926
144interferon-gamma secretion (GO:0072643)2.96725111
145activation of MAPKKK activity (GO:0000185)2.96251444
146regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.96054783
147positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.94221502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.45105351
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.57508001
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.65713237
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.52696535
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.91891544
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.76695629
7* IRF8_27001747_Chip-Seq_BMDM_Mouse4.43225082
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.75875393
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.53004929
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44141176
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.22833281
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.14122866
13* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.12334012
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.11998909
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10845863
16* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.07864664
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.58572623
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57450492
19* SPI1_23547873_ChIP-Seq_NB4_Human2.00883365
20* MYB_26560356_Chip-Seq_TH2_Human1.99318745
21RUNX_20019798_ChIP-Seq_JUKART_Human1.87062845
22BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84106773
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83477216
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82076036
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.82035567
26PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.76597604
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.76252729
28* MAF_26560356_Chip-Seq_TH1_Human1.70446046
29PU_27001747_Chip-Seq_BMDM_Mouse1.67187910
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.65381036
31* MYB_26560356_Chip-Seq_TH1_Human1.62938024
32CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59176684
33CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59136367
34VDR_24787735_ChIP-Seq_THP-1_Human1.56995768
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54668213
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53962968
37GATA1_22025678_ChIP-Seq_K562_Human1.49941714
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49522876
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.47392820
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44123302
41SPI1_23127762_ChIP-Seq_K562_Human1.44114332
42VDR_24763502_ChIP-Seq_THP-1_Human1.44098789
43GATA3_27048872_Chip-Seq_THYMUS_Human1.39126046
44GATA3_26560356_Chip-Seq_TH2_Human1.34444421
45CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33666045
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29467405
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28648193
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26443108
49PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24372777
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24325441
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23961638
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19642682
53SCL_19346495_ChIP-Seq_HPC-7_Human1.16423908
54* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15550888
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.15492745
56* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12347686
57VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12262186
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10916799
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10899177
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08914502
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08406175
62VDR_21846776_ChIP-Seq_THP-1_Human1.07391561
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06630811
64STAT1_20625510_ChIP-Seq_HELA_Human1.06363298
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03646839
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03646839
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03646839
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03060529
69UTX_26944678_Chip-Seq_JUKART_Human1.01699598
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00719531
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00443020
72GATA1_19941826_ChIP-Seq_K562_Human0.97921908
73KDM2B_26808549_Chip-Seq_DND41_Human0.94656592
74MAF_26560356_Chip-Seq_TH2_Human0.91318438
75NOTCH1_21737748_ChIP-Seq_TLL_Human0.91172366
76TP63_17297297_ChIP-ChIP_HaCaT_Human0.89928847
77GATA2_21666600_ChIP-Seq_HMVEC_Human0.88568084
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87483680
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85060082
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84684564
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84294636
82* LXR_22292898_ChIP-Seq_THP-1_Human0.82615690
83ESR1_21235772_ChIP-Seq_MCF-7_Human0.82304197
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81842497
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80560650
86GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80178496
87SMRT_27268052_Chip-Seq_Bcells_Human0.79687643
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.76434979
89* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73493179
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72111473
91TCF7_22412390_ChIP-Seq_EML_Mouse0.71702572
92* EGR1_19032775_ChIP-ChIP_M12_Human0.70450891
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69432783
94EGR1_23403033_ChIP-Seq_LIVER_Mouse0.67178869
95TFEB_21752829_ChIP-Seq_HELA_Human0.65621275
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.64811629
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.64689145
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.63955057
99BCL6_27268052_Chip-Seq_Bcells_Human0.63523702
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.63062038
101RXR_22158963_ChIP-Seq_LIVER_Mouse0.62059658
102* GATA1_19941827_ChIP-Seq_MEL_Mouse0.61395029
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61061463
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61061463
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.61023598
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.59221980
107SOX2_20726797_ChIP-Seq_SW620_Human0.57842228
108CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.56461709
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.55836248
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.55836248
111MYC_22102868_ChIP-Seq_BL_Human0.55259279
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.55244019
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.53501595
114ELK3_25401928_ChIP-Seq_HUVEC_Human0.53241724
115CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.52836857
116HOXB4_20404135_ChIP-ChIP_EML_Mouse0.52751290
117JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.52523121
118* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.52434335
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.49569545
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.49557543
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.49405684
122KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.49015900

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.62935093
2MP0009785_altered_susceptibility_to4.16139539
3MP0002148_abnormal_hypersensitivity_rea3.87383663
4MP0005671_abnormal_response_to3.57681271
5MP0000685_abnormal_immune_system3.50820162
6MP0003436_decreased_susceptibility_to3.49751931
7MP0005387_immune_system_phenotype3.47776438
8MP0001790_abnormal_immune_system3.47776438
9MP0005000_abnormal_immune_tolerance3.39306191
10MP0006082_CNS_inflammation3.32310625
11MP0005025_abnormal_response_to3.19404206
12MP0002419_abnormal_innate_immunity3.01810847
13MP0001800_abnormal_humoral_immune3.00311860
14MP0003303_peritoneal_inflammation2.99617995
15MP0002452_abnormal_antigen_presenting2.95783726
16MP0002723_abnormal_immune_serum2.83339835
17MP0004510_myositis2.80754437
18MP0003724_increased_susceptibility_to2.77059498
19* MP0001819_abnormal_immune_cell2.52689185
20* MP0002420_abnormal_adaptive_immunity2.46419311
21MP0005451_abnormal_body_composition2.34522394
22MP0002139_abnormal_hepatobiliary_system2.16916427
23MP0005058_abnormal_lysosome_morphology2.14905279
24MP0002006_tumorigenesis2.12373608
25MP0004947_skin_inflammation2.02142754
26MP0008004_abnormal_stomach_pH1.98516607
27MP0001853_heart_inflammation1.95173260
28MP0001845_abnormal_inflammatory_respons1.89664937
29MP0000716_abnormal_immune_system1.88677582
30MP0002405_respiratory_system_inflammati1.88139717
31MP0002166_altered_tumor_susceptibility1.87792986
32MP0002332_abnormal_exercise_endurance1.86867025
33MP0005464_abnormal_platelet_physiology1.84087141
34MP0002398_abnormal_bone_marrow1.83110967
35MP0009764_decreased_sensitivity_to1.82971127
36MP0005310_abnormal_salivary_gland1.81761639
37MP0001533_abnormal_skeleton_physiology1.80248405
38MP0003448_altered_tumor_morphology1.79534437
39MP0010155_abnormal_intestine_physiology1.75056864
40MP0000569_abnormal_digit_pigmentation1.63075868
41MP0003172_abnormal_lysosome_physiology1.61779457
42MP0008469_abnormal_protein_level1.61299356
43MP0003195_calcinosis1.50351158
44MP0002429_abnormal_blood_cell1.47702689
45MP0009333_abnormal_splenocyte_physiolog1.46147562
46MP0002138_abnormal_hepatobiliary_system1.41515624
47MP0000689_abnormal_spleen_morphology1.41268552
48MP0003075_altered_response_to1.39793019
49MP0006054_spinal_hemorrhage1.37795105
50MP0000858_altered_metastatic_potential1.36561303
51MP0003763_abnormal_thymus_physiology1.34835346
52MP0002998_abnormal_bone_remodeling1.31892923
53MP0002722_abnormal_immune_system1.31690614
54MP0004782_abnormal_surfactant_physiolog1.20521945
55MP0005397_hematopoietic_system_phenotyp1.17079294
56MP0001545_abnormal_hematopoietic_system1.17079294
57MP0009278_abnormal_bone_marrow1.15777934
58MP0002163_abnormal_gland_morphology1.15584531
59MP0000343_altered_response_to1.15116069
60MP0002277_abnormal_respiratory_mucosa1.14198217
61MP0005166_decreased_susceptibility_to1.11482035
62MP0010307_abnormal_tumor_latency1.10478231
63MP0003806_abnormal_nucleotide_metabolis1.10154378
64MP0002254_reproductive_system_inflammat1.07816190
65MP0000604_amyloidosis1.06781719
66MP0001348_abnormal_lacrimal_gland1.06360834
67MP0003646_muscle_fatigue1.02318461
68MP0003191_abnormal_cellular_cholesterol1.01288588
69MP0001501_abnormal_sleep_pattern1.01077322
70MP0003656_abnormal_erythrocyte_physiolo1.00055505
71MP0009763_increased_sensitivity_to0.95209896
72MP0003300_gastrointestinal_ulcer0.93825249
73MP0009840_abnormal_foam_cell0.92814158
74MP0005076_abnormal_cell_differentiation0.92781217
75MP0001542_abnormal_bone_strength0.90143730
76MP0001663_abnormal_digestive_system0.88445077
77MP0002933_joint_inflammation0.87313532
78MP0005174_abnormal_tail_pigmentation0.86179991
79MP0003186_abnormal_redox_activity0.84858268
80MP0005165_increased_susceptibility_to0.82975883
81MP0001873_stomach_inflammation0.80196879
82MP0000703_abnormal_thymus_morphology0.79504897
83MP0003183_abnormal_peptide_metabolism0.77900703
84MP0005390_skeleton_phenotype0.77624219
85MP0005164_abnormal_response_to0.76992098
86MP0005167_abnormal_blood-brain_barrier0.76907384
87MP0003091_abnormal_cell_migration0.76164886
88MP0003453_abnormal_keratinocyte_physiol0.74165374
89MP0008874_decreased_physiological_sensi0.73622924
90MP0005535_abnormal_body_temperature0.73055081
91MP0000371_diluted_coat_color0.71700593
92MP0003690_abnormal_glial_cell0.69490999
93MP0004883_abnormal_blood_vessel0.69179182
94MP0003045_fibrosis0.69065650
95MP0005647_abnormal_sex_gland0.67499181
96MP0000920_abnormal_myelination0.66761241
97MP0005266_abnormal_metabolism0.66156828
98MP0002136_abnormal_kidney_physiology0.65744452
99MP0000249_abnormal_blood_vessel0.65628734
100MP0001346_abnormal_lacrimal_gland0.65479246
101MP0004808_abnormal_hematopoietic_stem0.63722470
102MP0000015_abnormal_ear_pigmentation0.62997118
103MP0003866_abnormal_defecation0.61736892
104MP0003828_pulmonary_edema0.60872544
105MP0002693_abnormal_pancreas_physiology0.60643255
106MP0001851_eye_inflammation0.59419216
107MP0001881_abnormal_mammary_gland0.59406904
108MP0004858_abnormal_nervous_system0.58972646
109MP0005666_abnormal_adipose_tissue0.58607462
110MP0005023_abnormal_wound_healing0.58499278
111MP0008260_abnormal_autophagy0.58456498
112MP0010352_gastrointestinal_tract_polyps0.57842866
113MP0003566_abnormal_cell_adhesion0.53607550
114MP0002019_abnormal_tumor_incidence0.52739961
115MP0005381_digestive/alimentary_phenotyp0.51145963
116MP0005379_endocrine/exocrine_gland_phen0.49506367
117MP0003795_abnormal_bone_structure0.49276960
118MP0010386_abnormal_urinary_bladder0.48522956
119MP0000490_abnormal_crypts_of0.48370894
120MP0000609_abnormal_liver_physiology0.47467276
121MP0001764_abnormal_homeostasis0.46892580
122MP0005319_abnormal_enzyme/_coenzyme0.46801483
123MP0008057_abnormal_DNA_replication0.45035635
124MP0009765_abnormal_xenobiotic_induced0.44016883
125MP0000627_abnormal_mammary_gland0.43727916

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.81257539
2Eczematoid dermatitis (HP:0000976)6.80110610
3Recurrent bacterial skin infections (HP:0005406)6.42435099
4Recurrent gram-negative bacterial infections (HP:0005420)5.55810147
5Autoimmune thrombocytopenia (HP:0001973)5.06567492
6Mediastinal lymphadenopathy (HP:0100721)5.00062169
7Abnormality of macrophages (HP:0004311)4.98117966
8Elevated erythrocyte sedimentation rate (HP:0003565)4.76127532
9Increased IgM level (HP:0003496)4.75148612
10Recurrent fungal infections (HP:0002841)4.33270814
11Recurrent viral infections (HP:0004429)4.28338163
12Vasculitis (HP:0002633)4.22275178
13Recurrent skin infections (HP:0001581)4.17214573
14Myositis (HP:0100614)4.16978728
15Stomatitis (HP:0010280)4.13894510
16Retrobulbar optic neuritis (HP:0100654)4.13192866
17Optic neuritis (HP:0100653)4.13192866
18Orchitis (HP:0100796)3.98840272
19Gingivitis (HP:0000230)3.90962477
20Obstructive lung disease (HP:0006536)3.85158411
21Chronic obstructive pulmonary disease (HP:0006510)3.85158411
22Dysostosis multiplex (HP:0000943)3.79733316
23Chronic otitis media (HP:0000389)3.69489083
24Cellulitis (HP:0100658)3.54516890
25Increased cerebral lipofuscin (HP:0011813)3.54127562
26Basal ganglia calcification (HP:0002135)3.48127200
27Increased neuronal autofluorescent lipopigment (HP:0002074)3.41271747
28Vacuolated lymphocytes (HP:0001922)3.40674143
29Gangrene (HP:0100758)3.38301964
30Chronic mucocutaneous candidiasis (HP:0002728)3.33376167
31Recurrent cutaneous fungal infections (HP:0011370)3.33376167
32Meningitis (HP:0001287)3.30955058
33Gastrointestinal infarctions (HP:0005244)3.27706900
34Hypergammaglobulinemia (HP:0010702)3.23841277
35Interstitial pulmonary disease (HP:0006530)3.22967934
36Nuclear cataract (HP:0100018)3.22133911
37Mutism (HP:0002300)3.19538510
38Recurrent pneumonia (HP:0006532)3.16552561
39Pulmonary infiltrates (HP:0002113)3.12441813
40Recurrent bronchitis (HP:0002837)3.12185950
41Periodontitis (HP:0000704)3.10877507
42Abnormality of T cell number (HP:0011839)3.06777808
43Agammaglobulinemia (HP:0004432)3.06686085
44Parakeratosis (HP:0001036)2.96455387
45Pustule (HP:0200039)2.94817588
46Nasal polyposis (HP:0100582)2.90159932
47Abnormality of polysaccharide metabolism (HP:0011012)2.86174898
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86174898
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86174898
50Autoimmune hemolytic anemia (HP:0001890)2.85535494
51Osteomyelitis (HP:0002754)2.84956780
52Tetraparesis (HP:0002273)2.82145704
53Recurrent lower respiratory tract infections (HP:0002783)2.80294217
54Hemoptysis (HP:0002105)2.79681149
55Prostate neoplasm (HP:0100787)2.79288642
56Encephalitis (HP:0002383)2.77308111
57Leukocytosis (HP:0001974)2.74626666
58Glomerulonephritis (HP:0000099)2.73444375
59Abnormality of glycolipid metabolism (HP:0010969)2.73191367
60Abnormality of liposaccharide metabolism (HP:0010968)2.73191367
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.73191367
62Urinary glycosaminoglycan excretion (HP:0003541)2.71525112
63Mucopolysacchariduria (HP:0008155)2.71525112
64Urticaria (HP:0001025)2.70600826
65Systemic lupus erythematosus (HP:0002725)2.69865917
66Thick nail (HP:0001805)2.67849998
67Arterial thrombosis (HP:0004420)2.64918345
68T lymphocytopenia (HP:0005403)2.62974845
69Eosinophilia (HP:0001880)2.62952977
70Increased serum ferritin (HP:0003281)2.61750687
71Polyneuropathy (HP:0001271)2.59401987
72Neurofibrillary tangles (HP:0002185)2.53853818
73Loss of speech (HP:0002371)2.53709442
74Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51623636
75Chronic sinusitis (HP:0011109)2.48431690
76Premature loss of primary teeth (HP:0006323)2.48318851
77Apathy (HP:0000741)2.46032384
78Colitis (HP:0002583)2.45764928
79Abnormality of B cell number (HP:0010975)2.44050520
80Abnormality of the nasal mucosa (HP:0000433)2.43753219
81Abnormality of T cells (HP:0002843)2.42533691
82Gingival bleeding (HP:0000225)2.42133944
83Porencephaly (HP:0002132)2.41405335
84IgG deficiency (HP:0004315)2.40567976
85Progressive neurologic deterioration (HP:0002344)2.37546696
86Keratoconjunctivitis sicca (HP:0001097)2.36183221
87Myocardial infarction (HP:0001658)2.34192237
88Diminished motivation (HP:0000745)2.33933055
89Abnormal delayed hypersensitivity skin test (HP:0002963)2.33890371
90Disinhibition (HP:0000734)2.33598195
91Axonal loss (HP:0003447)2.32942074
92Thyroiditis (HP:0100646)2.31255047
93Gastrointestinal stroma tumor (HP:0100723)2.29959466
94Nausea (HP:0002018)2.27432791
95Poor head control (HP:0002421)2.27385240
96Abnormality of cells of the lymphoid lineage (HP:0012140)2.27123817
97Abnormality of eosinophils (HP:0001879)2.26361956
98Emphysema (HP:0002097)2.26043892
99B lymphocytopenia (HP:0010976)2.25758468
100Joint swelling (HP:0001386)2.25226831
101IgA deficiency (HP:0002720)2.23630457
102Inflammation of the large intestine (HP:0002037)2.23206006
103Granulocytopenia (HP:0001913)2.20317286
104Vertigo (HP:0002321)2.19943343
105Sepsis (HP:0100806)2.19897975
106Purpura (HP:0000979)2.18587546
107Abnormality of T cell physiology (HP:0011840)2.18509739
108Inappropriate behavior (HP:0000719)2.17990551
109Amyloidosis (HP:0011034)2.17758971
110Keratoconjunctivitis (HP:0001096)2.17520276
111Lymphopenia (HP:0001888)2.16690954
112Metaphyseal irregularity (HP:0003025)2.16563449
113Pulmonary embolism (HP:0002204)2.16387195
114Memory impairment (HP:0002354)2.14561030
115Keratitis (HP:0000491)2.12958917
116Anorexia (HP:0002039)2.12119452
117Arthralgia (HP:0002829)2.11076455
118Combined immunodeficiency (HP:0005387)2.09588378
119Gastrointestinal inflammation (HP:0004386)2.07990433
120Skin ulcer (HP:0200042)2.07789090
121Acne (HP:0001061)2.07545571
122Abnormality of iron homeostasis (HP:0011031)2.06069979
123Recurrent sinusitis (HP:0011108)2.05134002
124Glomerulopathy (HP:0100820)2.04225547
125Abnormality of the pericardium (HP:0001697)2.03840159
126Abnormality of the pleura (HP:0002103)2.02642761
127Abnormality of the endocardium (HP:0004306)2.02507729
128Increased IgE level (HP:0003212)2.00367751
129Hematochezia (HP:0002573)1.99609320
130Severe combined immunodeficiency (HP:0004430)1.99183218
131Agnosia (HP:0010524)1.98929164
132Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97130007
133Abnormality of the prostate (HP:0008775)1.96410452
134Osteolytic defects of the hand bones (HP:0009699)1.96148321
135Osteolytic defects of the phalanges of the hand (HP:0009771)1.96148321
136Neuronal loss in central nervous system (HP:0002529)1.95958449
137Complement deficiency (HP:0004431)1.93315998
138Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91332446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.36217257
2TBK13.84943606
3TYK23.80716535
4PBK3.74909165
5RIPK43.66975541
6BLK3.28527509
7IKBKE3.22131825
8JAK33.08759113
9IRAK43.04578594
10MAP4K12.91618791
11TAOK22.89039514
12IKBKB2.78726750
13JAK12.64976642
14DDR22.64905854
15PRPF4B2.62068468
16MAP3K132.61784226
17IRAK32.33065948
18TXK2.29963093
19KIT2.16417602
20CHUK1.82539253
21PIM21.81064336
22SYK1.75401094
23TAOK11.72611515
24FGFR41.54982848
25ERN11.51322001
26CDC42BPA1.49861491
27NEK91.46988473
28CSK1.42566965
29ZAP701.41990538
30BMPR21.39387191
31TAOK31.34849502
32MAP3K31.34595594
33TGFBR21.26818893
34HCK1.26772806
35CSF1R1.24517578
36FGFR31.24430533
37LYN1.19895332
38LCK1.18509233
39PIM11.17662082
40STK41.16695164
41MST41.13744009
42RPS6KA41.11941646
43EPHB11.10644750
44NME21.08769414
45BTK1.07015895
46EPHA31.05868360
47EIF2AK21.03667513
48JAK21.02914928
49BMX0.94694024
50MAP2K30.92047243
51TYRO30.89905291
52IRAK10.87657741
53ARAF0.86484986
54ACVR1B0.83986217
55TEC0.82817787
56MARK30.82657116
57MAP3K100.81748385
58SIK30.78710632
59MATK0.77345141
60PRKCQ0.76106753
61ABL20.75879433
62FGR0.71863873
63MAP3K50.70524928
64PRKCD0.68664871
65FES0.67882781
66HIPK20.66569645
67MST1R0.65804191
68ITK0.64776087
69LATS20.64309519
70ABL10.62929354
71TRPM70.61766494
72STK100.61410134
73DYRK30.60502948
74SIK20.58780763
75YES10.57920910
76EGFR0.53035423
77PKN10.52636951
78NLK0.52151275
79IRAK20.51657594
80MAP2K60.51617252
81ERBB30.50576130
82NUAK10.48194770
83MAPK40.47144214
84DAPK20.42802705
85GRK70.40387072
86TESK20.39218990
87GRK60.38101823
88STK30.36887609
89RPS6KA50.36691635
90MAPKAPK20.36457612
91CLK10.36287867
92PDGFRA0.35993999
93LRRK20.35472766
94ADRBK20.34928402
95MAPK70.34453335
96CDK120.31644942
97MOS0.30010251
98DAPK30.26252669
99RIPK10.24252065
100MAP3K10.24107942
101FYN0.23999082
102TESK10.23573920
103DYRK1B0.22603210
104PDK10.22336023
105BCR0.20857454
106BMPR1B0.20154967
107MAP3K110.19757194
108INSR0.19599391
109TLK10.19554089
110RPS6KA10.18862259
111RPS6KL10.18155872
112RPS6KC10.18155872
113IGF1R0.17192471
114STK240.16889439
115PDGFRB0.16819301
116RAF10.16673633
117CDK40.16654880
118PTK60.15510282
119CDK60.15481577
120RPS6KA60.14698735
121TNK20.14241127
122MAPK30.12856541
123MAP3K120.12373824
124PDPK10.12103001
125EIF2AK10.11570279
126MAPK110.10932611

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.02478403
2Allograft rejection_Homo sapiens_hsa053303.73316617
3Leishmaniasis_Homo sapiens_hsa051403.12704162
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.94503643
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.81042521
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.80837986
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.75680390
8Measles_Homo sapiens_hsa051622.45231400
9Type I diabetes mellitus_Homo sapiens_hsa049402.44540286
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.42353186
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.40534640
12Legionellosis_Homo sapiens_hsa051342.21200419
13Osteoclast differentiation_Homo sapiens_hsa043802.15640774
14Staphylococcus aureus infection_Homo sapiens_hsa051502.12595106
15Influenza A_Homo sapiens_hsa051642.09330332
16Autoimmune thyroid disease_Homo sapiens_hsa053202.05100448
17Pertussis_Homo sapiens_hsa051332.04840119
18Asthma_Homo sapiens_hsa053102.04000795
19Rheumatoid arthritis_Homo sapiens_hsa053232.03680766
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02711434
21Primary immunodeficiency_Homo sapiens_hsa053401.97630742
22TNF signaling pathway_Homo sapiens_hsa046681.96659927
23Malaria_Homo sapiens_hsa051441.96016030
24Tuberculosis_Homo sapiens_hsa051521.95571865
25Herpes simplex infection_Homo sapiens_hsa051681.85062754
26Antigen processing and presentation_Homo sapiens_hsa046121.78848145
27B cell receptor signaling pathway_Homo sapiens_hsa046621.73572762
28African trypanosomiasis_Homo sapiens_hsa051431.63386981
29Toxoplasmosis_Homo sapiens_hsa051451.63218403
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61394910
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50380773
32Viral myocarditis_Homo sapiens_hsa054161.48725921
33Salmonella infection_Homo sapiens_hsa051321.48414421
34Chemokine signaling pathway_Homo sapiens_hsa040621.46593049
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.45364923
36Apoptosis_Homo sapiens_hsa042101.42083391
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38460988
38Lysosome_Homo sapiens_hsa041421.37616616
39Hematopoietic cell lineage_Homo sapiens_hsa046401.30358133
40Phagosome_Homo sapiens_hsa041451.25164847
41Shigellosis_Homo sapiens_hsa051311.16584760
42Hepatitis C_Homo sapiens_hsa051601.14687352
43Hepatitis B_Homo sapiens_hsa051611.12272819
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08770778
45T cell receptor signaling pathway_Homo sapiens_hsa046601.05918553
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96326424
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86444014
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81373947
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.79133399
50Other glycan degradation_Homo sapiens_hsa005110.76307221
51Acute myeloid leukemia_Homo sapiens_hsa052210.74080626
52Epstein-Barr virus infection_Homo sapiens_hsa051690.70886182
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.70642203
54Prolactin signaling pathway_Homo sapiens_hsa049170.69774965
55Amoebiasis_Homo sapiens_hsa051460.66424565
56Bladder cancer_Homo sapiens_hsa052190.66154030
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57120130
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55231527
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54983330
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53879244
61Sphingolipid metabolism_Homo sapiens_hsa006000.52496346
62Chronic myeloid leukemia_Homo sapiens_hsa052200.50979813
63Collecting duct acid secretion_Homo sapiens_hsa049660.50618593
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50602349
65Viral carcinogenesis_Homo sapiens_hsa052030.50529036
66Pancreatic cancer_Homo sapiens_hsa052120.48009205
67Small cell lung cancer_Homo sapiens_hsa052220.47053379
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.46624615
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46127053
70Prion diseases_Homo sapiens_hsa050200.45564669
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.44624579
72Proteasome_Homo sapiens_hsa030500.43120263
73Tryptophan metabolism_Homo sapiens_hsa003800.42610808
74Platelet activation_Homo sapiens_hsa046110.42554983
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41859822
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40971396
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39558899
78Sulfur metabolism_Homo sapiens_hsa009200.39445389
79HIF-1 signaling pathway_Homo sapiens_hsa040660.37048104
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36146305
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36052840
82HTLV-I infection_Homo sapiens_hsa051660.34512481
83Type II diabetes mellitus_Homo sapiens_hsa049300.32372783
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.30806939
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26943159
86Dorso-ventral axis formation_Homo sapiens_hsa043200.24667894
87p53 signaling pathway_Homo sapiens_hsa041150.23630884
88VEGF signaling pathway_Homo sapiens_hsa043700.23416812
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23025607
90Mineral absorption_Homo sapiens_hsa049780.18363151
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18344627
92Systemic lupus erythematosus_Homo sapiens_hsa053220.17780110
93FoxO signaling pathway_Homo sapiens_hsa040680.15320359
94Complement and coagulation cascades_Homo sapiens_hsa046100.14581762
95Endocytosis_Homo sapiens_hsa041440.13946556
96Proteoglycans in cancer_Homo sapiens_hsa052050.13405025
97Notch signaling pathway_Homo sapiens_hsa043300.12773511
98Insulin resistance_Homo sapiens_hsa049310.12452854
99MicroRNAs in cancer_Homo sapiens_hsa052060.12361495
100Caffeine metabolism_Homo sapiens_hsa002320.12291638
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10559328
102MAPK signaling pathway_Homo sapiens_hsa040100.10164521
103PPAR signaling pathway_Homo sapiens_hsa033200.08690438
104Fructose and mannose metabolism_Homo sapiens_hsa000510.07409104
105Galactose metabolism_Homo sapiens_hsa000520.07160492
106Renin-angiotensin system_Homo sapiens_hsa046140.06171046
107Vibrio cholerae infection_Homo sapiens_hsa051100.05256554
108Prostate cancer_Homo sapiens_hsa052150.04609450
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.04290718
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.02725535
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.01734467

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »