SLAMF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. These proteins are characterized by Ig domains. This protein is expressed in lymphoid tissues, and studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing many CD2 genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.84498718
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.84498718
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.84498718
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.84498718
5modulation by symbiont of host immune response (GO:0052553)6.84498718
6positive regulation by symbiont of host defense response (GO:0052509)6.84498718
7antigen processing and presentation of endogenous antigen (GO:0019883)6.55328425
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.44249355
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.33596265
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.33596265
11positive regulation of interferon-alpha production (GO:0032727)5.51557039
12regulation of interferon-beta biosynthetic process (GO:0045357)5.22854699
13regulation of interferon-alpha production (GO:0032647)5.17576446
14immunoglobulin mediated immune response (GO:0016064)5.00597119
15positive regulation of antigen processing and presentation (GO:0002579)4.98662296
16respiratory burst (GO:0045730)4.94566788
17macrophage activation involved in immune response (GO:0002281)4.91872602
18glycolipid catabolic process (GO:0019377)4.89971553
19cellular response to thyroid hormone stimulus (GO:0097067)4.83151623
20negative regulation of interleukin-12 production (GO:0032695)4.81773977
21oligosaccharide catabolic process (GO:0009313)4.77305022
22microglial cell activation (GO:0001774)4.76737930
23neutrophil activation involved in immune response (GO:0002283)4.72701675
24type I interferon signaling pathway (GO:0060337)4.63350657
25cellular response to type I interferon (GO:0071357)4.63350657
26response to type I interferon (GO:0034340)4.58506849
27response to peptidoglycan (GO:0032494)4.51735491
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.49611021
29response to host immune response (GO:0052572)4.49611021
30regulation of dendritic cell antigen processing and presentation (GO:0002604)4.47133246
31amino sugar catabolic process (GO:0046348)4.40612236
32regulation of antigen processing and presentation (GO:0002577)4.36073804
33ceramide catabolic process (GO:0046514)4.35358710
34cellular extravasation (GO:0045123)4.30422759
35positive regulation of chemokine biosynthetic process (GO:0045080)4.24946222
36regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.20590585
37interferon-gamma-mediated signaling pathway (GO:0060333)4.16510873
38regulation of macrophage chemotaxis (GO:0010758)4.15012397
39cellular response to interferon-beta (GO:0035458)4.14614044
40hydrogen peroxide biosynthetic process (GO:0050665)4.11270154
41natural killer cell mediated cytotoxicity (GO:0042267)4.10811383
42natural killer cell mediated immunity (GO:0002228)4.10811383
43positive regulation of interferon-beta production (GO:0032728)4.03485183
44response to host (GO:0075136)3.99394469
45response to host defenses (GO:0052200)3.99394469
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.99394469
47defense response to protozoan (GO:0042832)3.93672665
48macrophage activation (GO:0042116)3.86052236
49positive regulation of monocyte chemotaxis (GO:0090026)3.84240526
50lipopolysaccharide-mediated signaling pathway (GO:0031663)3.81610847
51response to thyroid hormone (GO:0097066)3.79323580
52cellular response to exogenous dsRNA (GO:0071360)3.78085916
53regulation of B cell receptor signaling pathway (GO:0050855)3.77352358
54barbed-end actin filament capping (GO:0051016)3.73060266
55positive regulation of mast cell degranulation (GO:0043306)3.69656623
56positive regulation of mast cell activation involved in immune response (GO:0033008)3.69656623
57response to interferon-beta (GO:0035456)3.69123890
58membrane lipid catabolic process (GO:0046466)3.61579096
59reactive oxygen species biosynthetic process (GO:1903409)3.61075868
60B cell mediated immunity (GO:0019724)3.58006390
61cellular response to interferon-gamma (GO:0071346)3.53389028
62apoptotic cell clearance (GO:0043277)3.52976169
63positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.50026613
64sphingolipid catabolic process (GO:0030149)3.48933607
65positive regulation of leukocyte degranulation (GO:0043302)3.48674615
66regulation of chemokine biosynthetic process (GO:0045073)3.47467902
67superoxide anion generation (GO:0042554)3.47174826
68myeloid cell activation involved in immune response (GO:0002275)3.45165305
69eosinophil migration (GO:0072677)3.45005082
70response to interferon-alpha (GO:0035455)3.42223226
71phagosome maturation (GO:0090382)3.42109536
72positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.42077179
73positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.41296942
74positive regulation of cellular amide metabolic process (GO:0034250)3.39194841
75positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.38813621
76macrophage differentiation (GO:0030225)3.37528549
77regulation of mononuclear cell migration (GO:0071675)3.35471392
78myeloid dendritic cell differentiation (GO:0043011)3.35434955
79negative regulation of viral genome replication (GO:0045071)3.35020246
80cellular response to cadmium ion (GO:0071276)3.34617766
81granulocyte activation (GO:0036230)3.32185389
82response to protozoan (GO:0001562)3.31499118
83response to interferon-gamma (GO:0034341)3.26768943
84lymphocyte chemotaxis (GO:0048247)3.26590941
85negative regulation of mast cell activation (GO:0033004)3.24672030
86N-acetylneuraminate metabolic process (GO:0006054)3.23884651
87negative regulation of cell killing (GO:0031342)3.22260005
88negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.22260005
89fat-soluble vitamin biosynthetic process (GO:0042362)3.21748946
90positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.21388505
91peptide catabolic process (GO:0043171)3.19129204
92response to muramyl dipeptide (GO:0032495)3.17274774
93positive regulation of toll-like receptor signaling pathway (GO:0034123)3.16920234
94adhesion of symbiont to host cell (GO:0044650)3.15900142
95virion attachment to host cell (GO:0019062)3.15900142
96regulation of mast cell activation involved in immune response (GO:0033006)3.15766974
97cellular response to interferon-alpha (GO:0035457)3.13751569
98detection of molecule of bacterial origin (GO:0032490)3.12390436
99regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.11719458
100eosinophil chemotaxis (GO:0048245)3.09630670
101positive regulation of type 2 immune response (GO:0002830)3.09372036
102detection of other organism (GO:0098543)3.08996202
103regulation of leukocyte degranulation (GO:0043300)3.08801224
104positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.08494936
105regulation of monocyte chemotaxis (GO:0090025)3.08134982
106T-helper 1 type immune response (GO:0042088)3.08002165
107lymphocyte mediated immunity (GO:0002449)3.07850660
108neutrophil activation (GO:0042119)3.07726701
109* intracellular pH reduction (GO:0051452)3.06923194
110regulation of hypersensitivity (GO:0002883)3.06372611
111regulation of vitamin D biosynthetic process (GO:0060556)3.05858507
112regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05259941
113myeloid dendritic cell activation (GO:0001773)3.03379928
114leukocyte mediated cytotoxicity (GO:0001909)3.03070002
115low-density lipoprotein particle clearance (GO:0034383)3.02561873
116monocyte chemotaxis (GO:0002548)3.01211704
117positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.00989927
118glycosphingolipid catabolic process (GO:0046479)2.99707401
119negative regulation of myeloid cell apoptotic process (GO:0033033)2.99440402
120regulation of mast cell degranulation (GO:0043304)2.99005216
121T cell migration (GO:0072678)2.97452979
122positive regulation of interleukin-12 production (GO:0032735)2.96108986
123regulation of cholesterol storage (GO:0010885)2.96096173
124detection of external biotic stimulus (GO:0098581)2.95310038
125positive regulation of macrophage cytokine production (GO:0060907)2.95269771
126production of molecular mediator involved in inflammatory response (GO:0002532)2.93674553
127NIK/NF-kappaB signaling (GO:0038061)2.92563036
128positive regulation of gamma-delta T cell activation (GO:0046645)2.92274395
129pinocytosis (GO:0006907)2.89519023
130I-kappaB phosphorylation (GO:0007252)2.88965591
131positive regulation of cAMP-mediated signaling (GO:0043950)2.87948473
132regulation of interferon-beta production (GO:0032648)2.87293145
133defense response to virus (GO:0051607)2.86519936
134myeloid leukocyte activation (GO:0002274)2.86279371
135granulocyte chemotaxis (GO:0071621)2.85610114
136regulation of T cell tolerance induction (GO:0002664)2.84967319
137negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.84866003
138detection of bacterium (GO:0016045)2.84511391
139regulation of mast cell activation (GO:0033003)2.83932479
140dendritic cell differentiation (GO:0097028)2.82706706
141regulation of superoxide anion generation (GO:0032928)2.82640333
142cellular response to zinc ion (GO:0071294)2.82103716
143positive regulation of mast cell activation (GO:0033005)2.81255646
144regulation of gamma-delta T cell activation (GO:0046643)2.80507241
145neutrophil chemotaxis (GO:0030593)2.80488747
146germinal center formation (GO:0002467)2.79659593
147regulation of podosome assembly (GO:0071801)2.76055400
148adhesion of symbiont to host (GO:0044406)2.75011803
149granulocyte migration (GO:0097530)2.73774390
150neutrophil migration (GO:1990266)2.73069266
151angiotensin maturation (GO:0002003)2.72915965
152positive regulation of bone remodeling (GO:0046852)2.71959880
153positive regulation of bone resorption (GO:0045780)2.71959880
154regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.70412111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.26832977
2IRF8_21731497_ChIP-ChIP_J774_Mouse8.04038760
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.90923592
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.80619629
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.87820851
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.74679884
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.04893920
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.66398968
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.61930045
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.02332142
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94311280
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.76284621
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54168696
14* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.53465131
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48529955
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44817993
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41678680
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40315215
19* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26585155
20BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97788535
21EGR1_19374776_ChIP-ChIP_THP-1_Human1.93653159
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.92881629
23PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.81052511
24CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.79349889
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.77297226
26SPI1_23547873_ChIP-Seq_NB4_Human1.75907500
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75054243
28LXR_22292898_ChIP-Seq_THP-1_Human1.72678962
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72008353
30CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65019621
31SPI1_23127762_ChIP-Seq_K562_Human1.61876835
32PU_27001747_Chip-Seq_BMDM_Mouse1.56364179
33MYB_26560356_Chip-Seq_TH2_Human1.55635072
34VDR_24787735_ChIP-Seq_THP-1_Human1.53009209
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52297834
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50379658
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.49202793
38VDR_24763502_ChIP-Seq_THP-1_Human1.47514827
39PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44372186
40MAF_26560356_Chip-Seq_TH1_Human1.36568356
41GATA1_22025678_ChIP-Seq_K562_Human1.32665317
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.29675734
43RUNX_20019798_ChIP-Seq_JUKART_Human1.29151058
44CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27702152
45EGR1_19032775_ChIP-ChIP_M12_Human1.24377320
46CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21164899
47PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20011178
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18069809
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17224508
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16193426
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14903627
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14308157
53LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10410245
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09619813
55GATA3_26560356_Chip-Seq_TH2_Human1.09508893
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08244536
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07695813
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07305302
59MYB_26560356_Chip-Seq_TH1_Human1.06624696
60GATA2_21666600_ChIP-Seq_HMVEC_Human1.06252116
61GATA3_27048872_Chip-Seq_THYMUS_Human1.05696389
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03679241
63* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03525242
64KDM2B_26808549_Chip-Seq_DND41_Human1.03458265
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02161482
66SCL_19346495_ChIP-Seq_HPC-7_Human1.01177331
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01075575
68STAT1_20625510_ChIP-Seq_HELA_Human0.99796173
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99637118
70BCL6_27268052_Chip-Seq_Bcells_Human0.99591433
71VDR_21846776_ChIP-Seq_THP-1_Human0.98434625
72EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97807250
73TRIM28_21343339_ChIP-Seq_HEK293_Human0.97046326
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95991277
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95788540
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94066695
77ESR2_21235772_ChIP-Seq_MCF-7_Human0.93285405
78SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93188892
79BCOR_27268052_Chip-Seq_Bcells_Human0.91489844
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91168378
81* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91027103
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90353043
83UTX_26944678_Chip-Seq_JUKART_Human0.90329594
84SOX2_20726797_ChIP-Seq_SW620_Human0.88220799
85MYC_22102868_ChIP-Seq_BL_Human0.87470587
86NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87341231
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87341231
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.85628447
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84203028
90RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81153255
91CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78759690
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77974098
93SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.77616405
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77608301
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.76525634
96LXR_22158963_ChIP-Seq_LIVER_Mouse0.76090596
97GATA1_19941827_ChIP-Seq_MEL_Mouse0.75896575
98KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74469481
99JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72611390
100CJUN_26792858_Chip-Seq_BT549_Human0.72234608
101GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68828900
102MAF_26560356_Chip-Seq_TH2_Human0.68732667
103FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.68649253
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68462777
105PPARA_22158963_ChIP-Seq_LIVER_Mouse0.68374509
106RXR_22158963_ChIP-Seq_LIVER_Mouse0.67709728
107TFEB_21752829_ChIP-Seq_HELA_Human0.67496866
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67285258
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.64968854
110TCF7_22412390_ChIP-Seq_EML_Mouse0.64407443
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.63125375
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62138921
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.62053375
114TP63_17297297_ChIP-ChIP_HaCaT_Human0.61733623
115SPI1_20517297_ChIP-Seq_HL60_Human0.61273388
116GATA2_19941826_ChIP-Seq_K562_Human0.60702138
117GATA1_19941826_ChIP-Seq_K562_Human0.60531141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.13127798
2MP0006082_CNS_inflammation4.03702842
3MP0004510_myositis3.84478151
4MP0003303_peritoneal_inflammation3.72142074
5MP0005058_abnormal_lysosome_morphology3.67013820
6MP0009785_altered_susceptibility_to3.57609888
7MP0003436_decreased_susceptibility_to3.50270382
8MP0002419_abnormal_innate_immunity3.11495881
9MP0002148_abnormal_hypersensitivity_rea3.01886615
10MP0005025_abnormal_response_to3.01864635
11MP0005387_immune_system_phenotype2.93590730
12MP0001790_abnormal_immune_system2.93590730
13MP0005000_abnormal_immune_tolerance2.91635300
14MP0005671_abnormal_response_to2.69179388
15MP0003724_increased_susceptibility_to2.69109219
16MP0003172_abnormal_lysosome_physiology2.64181310
17MP0002452_abnormal_antigen_presenting2.58630695
18MP0000685_abnormal_immune_system2.52274367
19MP0002139_abnormal_hepatobiliary_system2.48080525
20MP0001800_abnormal_humoral_immune2.36757093
21MP0002723_abnormal_immune_serum2.33102150
22MP0001853_heart_inflammation2.13242659
23MP0004947_skin_inflammation2.13110952
24MP0005464_abnormal_platelet_physiology2.12572664
25MP0001533_abnormal_skeleton_physiology2.10557462
26MP0001819_abnormal_immune_cell2.10138461
27MP0002420_abnormal_adaptive_immunity2.03133863
28MP0000604_amyloidosis1.99070940
29MP0003075_altered_response_to1.98450465
30MP0003448_altered_tumor_morphology1.98040119
31MP0000343_altered_response_to1.93679306
32MP0004858_abnormal_nervous_system1.85191438
33MP0003191_abnormal_cellular_cholesterol1.83404878
34MP0001845_abnormal_inflammatory_respons1.81567810
35MP0003690_abnormal_glial_cell1.75799927
36MP0003806_abnormal_nucleotide_metabolis1.73451743
37MP0009764_decreased_sensitivity_to1.67978956
38MP0009840_abnormal_foam_cell1.66456819
39MP0005310_abnormal_salivary_gland1.64184961
40MP0008469_abnormal_protein_level1.63905337
41MP0002405_respiratory_system_inflammati1.62165327
42MP0002998_abnormal_bone_remodeling1.60823402
43MP0005166_decreased_susceptibility_to1.51620481
44MP0010155_abnormal_intestine_physiology1.48447240
45MP0009333_abnormal_splenocyte_physiolog1.48336462
46MP0000716_abnormal_immune_system1.42899783
47MP0002166_altered_tumor_susceptibility1.39135555
48MP0004782_abnormal_surfactant_physiolog1.38346601
49MP0002006_tumorigenesis1.37468804
50MP0010307_abnormal_tumor_latency1.33406461
51MP0001851_eye_inflammation1.29053036
52MP0005365_abnormal_bile_salt1.27109183
53MP0005167_abnormal_blood-brain_barrier1.21995442
54MP0002398_abnormal_bone_marrow1.20809285
55MP0003300_gastrointestinal_ulcer1.18369554
56MP0005164_abnormal_response_to1.17200736
57MP0005257_abnormal_intraocular_pressure1.16283531
58MP0002933_joint_inflammation1.14091217
59MP0000858_altered_metastatic_potential1.13882013
60MP0000689_abnormal_spleen_morphology1.12901742
61MP0002429_abnormal_blood_cell1.11118973
62MP0002090_abnormal_vision1.07799583
63MP0003279_aneurysm1.07417595
64MP0010386_abnormal_urinary_bladder1.05506525
65MP0008260_abnormal_autophagy1.00271954
66MP0002722_abnormal_immune_system0.98267469
67MP0002837_dystrophic_cardiac_calcinosis0.97486128
68MP0005390_skeleton_phenotype0.96450163
69MP0003329_amyloid_beta_deposits0.93794952
70MP0002877_abnormal_melanocyte_morpholog0.92351528
71MP0003566_abnormal_cell_adhesion0.91530438
72MP0009763_increased_sensitivity_to0.88205851
73MP0003186_abnormal_redox_activity0.87493316
74MP0008438_abnormal_cutaneous_collagen0.86905658
75MP0000371_diluted_coat_color0.85759087
76MP0009278_abnormal_bone_marrow0.83913759
77MP0002254_reproductive_system_inflammat0.83309235
78MP0000249_abnormal_blood_vessel0.82478060
79MP0005397_hematopoietic_system_phenotyp0.81042037
80MP0001545_abnormal_hematopoietic_system0.81042037
81MP0000465_gastrointestinal_hemorrhage0.78512267
82MP0001849_ear_inflammation0.77025767
83MP0000569_abnormal_digit_pigmentation0.76470906
84MP0005451_abnormal_body_composition0.74861318
85MP0004019_abnormal_vitamin_homeostasis0.74443330
86MP0006054_spinal_hemorrhage0.74223557
87MP0008874_decreased_physiological_sensi0.73183658
88MP0005647_abnormal_sex_gland0.72656923
89MP0000920_abnormal_myelination0.70145031
90MP0002136_abnormal_kidney_physiology0.69393133
91MP0003828_pulmonary_edema0.69041253
92MP0003656_abnormal_erythrocyte_physiolo0.68820915
93MP0000015_abnormal_ear_pigmentation0.68243910
94MP0003795_abnormal_bone_structure0.68044583
95MP0004883_abnormal_blood_vessel0.67631952
96MP0009765_abnormal_xenobiotic_induced0.67486584
97MP0002896_abnormal_bone_mineralization0.67215135
98MP0003453_abnormal_keratinocyte_physiol0.64738687
99MP0003183_abnormal_peptide_metabolism0.64589614
100MP0001501_abnormal_sleep_pattern0.63268903
101MP0005197_abnormal_uvea_morphology0.62445251
102MP0005023_abnormal_wound_healing0.61943496
103MP0001958_emphysema0.61194509
104MP0002277_abnormal_respiratory_mucosa0.60454254
105MP0003045_fibrosis0.59733499
106MP0005595_abnormal_vascular_smooth0.58535052
107MP0005319_abnormal_enzyme/_coenzyme0.57513699
108MP0002138_abnormal_hepatobiliary_system0.55989594
109MP0003091_abnormal_cell_migration0.55088666
110MP0002693_abnormal_pancreas_physiology0.54855989
111MP0003705_abnormal_hypodermis_morpholog0.51764414
112MP0003634_abnormal_glial_cell0.50658508
113MP0005076_abnormal_cell_differentiation0.50472888
114MP0003195_calcinosis0.50378865
115MP0002332_abnormal_exercise_endurance0.50174586
116MP0001663_abnormal_digestive_system0.48100428
117MP0008004_abnormal_stomach_pH0.47598640
118MP0005165_increased_susceptibility_to0.47304002

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.11465727
2Increased cerebral lipofuscin (HP:0011813)6.62961676
3Eczematoid dermatitis (HP:0000976)6.44892542
4Recurrent gram-negative bacterial infections (HP:0005420)6.39522472
5Recurrent bacterial skin infections (HP:0005406)6.22059174
6Increased neuronal autofluorescent lipopigment (HP:0002074)5.53571098
7Abnormality of macrophages (HP:0004311)5.15897602
8Abnormality of liposaccharide metabolism (HP:0010968)4.96861531
9Abnormality of glycosphingolipid metabolism (HP:0004343)4.96861531
10Abnormality of glycolipid metabolism (HP:0010969)4.96861531
11Chronic otitis media (HP:0000389)4.83352560
12Elevated erythrocyte sedimentation rate (HP:0003565)4.67224351
13Systemic lupus erythematosus (HP:0002725)4.64631496
14Vacuolated lymphocytes (HP:0001922)4.50678461
15Mediastinal lymphadenopathy (HP:0100721)4.37865932
16Loss of speech (HP:0002371)4.32989949
17Obstructive lung disease (HP:0006536)4.06532228
18Chronic obstructive pulmonary disease (HP:0006510)4.06532228
19Recurrent skin infections (HP:0001581)4.04270886
20Gingivitis (HP:0000230)3.95341208
21Autoimmune thrombocytopenia (HP:0001973)3.95250497
22Mutism (HP:0002300)3.91481942
23Dysostosis multiplex (HP:0000943)3.57026011
24Stomatitis (HP:0010280)3.43741985
25Myositis (HP:0100614)3.40072099
26Recurrent fungal infections (HP:0002841)3.34725825
27Basal ganglia calcification (HP:0002135)3.34510594
28Nasal polyposis (HP:0100582)3.33744755
29Neurofibrillary tangles (HP:0002185)3.31350393
30Axonal loss (HP:0003447)3.22949198
31Recurrent viral infections (HP:0004429)3.14342863
32Mucopolysacchariduria (HP:0008155)3.13194315
33Urinary glycosaminoglycan excretion (HP:0003541)3.13194315
34Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.12865171
35Interstitial pulmonary disease (HP:0006530)3.10954526
36Hepatosplenomegaly (HP:0001433)3.09113852
37Abnormality of the nasal mucosa (HP:0000433)3.09090054
38Recurrent cutaneous fungal infections (HP:0011370)3.06374352
39Chronic mucocutaneous candidiasis (HP:0002728)3.06374352
40Orchitis (HP:0100796)3.05516550
41Disinhibition (HP:0000734)2.98301369
42Vasculitis (HP:0002633)2.94978014
43Abnormality of mucopolysaccharide metabolism (HP:0011020)2.94579311
44Abnormality of polysaccharide metabolism (HP:0011012)2.94579311
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.94579311
46Metaphyseal irregularity (HP:0003025)2.90249350
47Myocardial infarction (HP:0001658)2.85792937
48Upper motor neuron abnormality (HP:0002127)2.79969718
49Spontaneous hematomas (HP:0007420)2.79076730
50Glomerulonephritis (HP:0000099)2.78506928
51Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.76894172
52Periodontitis (HP:0000704)2.74559584
53Cellulitis (HP:0100658)2.73853166
54Increased IgM level (HP:0003496)2.68558265
55Urticaria (HP:0001025)2.65327463
56Poor head control (HP:0002421)2.64979405
57Neuronal loss in central nervous system (HP:0002529)2.59538992
58Optic neuritis (HP:0100653)2.57541565
59Retrobulbar optic neuritis (HP:0100654)2.57541565
60Tetraparesis (HP:0002273)2.56886703
61Recurrent bronchitis (HP:0002837)2.51985656
62Malnutrition (HP:0004395)2.51596877
63Nuclear cataract (HP:0100018)2.47129255
64Premature loss of primary teeth (HP:0006323)2.46074047
65Nephritis (HP:0000123)2.45408986
66Osteomyelitis (HP:0002754)2.45181077
67Emphysema (HP:0002097)2.42582914
68Thick nail (HP:0001805)2.42349169
69Pustule (HP:0200039)2.40029129
70Chronic sinusitis (HP:0011109)2.38534602
71Cerebral inclusion bodies (HP:0100314)2.34503679
72Protuberant abdomen (HP:0001538)2.32761198
73Progressive visual loss (HP:0000529)2.32599176
74Bone pain (HP:0002653)2.32075049
75Pulmonary infiltrates (HP:0002113)2.29452707
76Meningitis (HP:0001287)2.29182843
77Recurrent pneumonia (HP:0006532)2.28201693
78Prostate neoplasm (HP:0100787)2.27345809
79Hypergammaglobulinemia (HP:0010702)2.24777994
80Hematochezia (HP:0002573)2.24390495
81Progressive neurologic deterioration (HP:0002344)2.24316684
82Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22828875
83Colitis (HP:0002583)2.22353336
84Retinal atrophy (HP:0001105)2.21908813
85Inappropriate behavior (HP:0000719)2.18249016
86Recurrent lower respiratory tract infections (HP:0002783)2.17653822
87Abnormality of the periventricular white matter (HP:0002518)2.17435410
88Gingival bleeding (HP:0000225)2.16618813
89Petechiae (HP:0000967)2.15717267
90Thoracic kyphosis (HP:0002942)2.13027030
91Leukocytosis (HP:0001974)2.12460005
92Abnormality of complement system (HP:0005339)2.10199932
93Dementia (HP:0000726)2.10015452
94Agnosia (HP:0010524)2.09697440
95Diminished motivation (HP:0000745)2.09088059
96Pathologic fracture (HP:0002756)2.07384022
97Conjunctival telangiectasia (HP:0000524)2.06917776
98Purpura (HP:0000979)2.06539880
99Joint hemorrhage (HP:0005261)2.05143360
100Amyloidosis (HP:0011034)2.04490446
101Personality changes (HP:0000751)2.04009061
102Hemoptysis (HP:0002105)2.02573659
103Apathy (HP:0000741)1.98826525
104Xanthomatosis (HP:0000991)1.98781825
105Restrictive lung disease (HP:0002091)1.95281383
106Cardiomegaly (HP:0001640)1.93115075
107Esophageal varix (HP:0002040)1.92221324
108Abnormality of iron homeostasis (HP:0011031)1.92093982
109Vertebral compression fractures (HP:0002953)1.91748295
110Nausea (HP:0002018)1.91381194
111Thin bony cortex (HP:0002753)1.90233228
112Arterial thrombosis (HP:0004420)1.87094066
113J-shaped sella turcica (HP:0002680)1.85705268
114Prolonged neonatal jaundice (HP:0006579)1.84688179
115Porencephaly (HP:0002132)1.84669642
116Osteolytic defects of the hand bones (HP:0009699)1.84565977
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.84565977
118Supranuclear gaze palsy (HP:0000605)1.82312047
119Peripheral demyelination (HP:0011096)1.82144674
120Abnormality of the pericardium (HP:0001697)1.81556386
121Inflammation of the large intestine (HP:0002037)1.81201864
122Complement deficiency (HP:0004431)1.81007054
123Increased serum ferritin (HP:0003281)1.80153155
124Skin ulcer (HP:0200042)1.79870787
125Asymmetric septal hypertrophy (HP:0001670)1.79336901
126Global brain atrophy (HP:0002283)1.75964308
127Increased CSF protein (HP:0002922)1.75723596
128T lymphocytopenia (HP:0005403)1.74476770
129Spondylolisthesis (HP:0003302)1.72896171

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.72575392
2BLK4.49425816
3TBK14.21388410
4KIT3.60637354
5RIPK43.52648314
6TYK23.49380276
7MAP3K143.27537330
8ERN13.04901767
9IRAK32.94072519
10IKBKE2.92954165
11IRAK42.55732742
12MAP4K12.35936417
13DDR22.15070888
14JAK12.13299455
15JAK32.11429247
16IKBKB1.97352148
17PRPF4B1.83054286
18CAMKK21.79406575
19ACVR1B1.75761617
20FGR1.74845551
21TXK1.74593634
22CSF1R1.71312660
23FGFR41.70366792
24CSK1.69150950
25CDC42BPA1.65528358
26TAOK31.63538685
27SYK1.58894264
28BMX1.54203235
29MAP3K131.48097103
30NME21.47956128
31NEK91.46434989
32MATK1.45937763
33ABL21.45197193
34FES1.42466956
35TAOK21.41173764
36TGFBR21.40966423
37ZAP701.35466337
38EPHB11.29693686
39HCK1.29476185
40TESK21.28214356
41RPS6KA41.26778799
42PIM21.22613661
43LYN1.21600841
44TAOK11.20132418
45PDK21.11920465
46LCK1.08938701
47JAK21.03862698
48LIMK11.00219382
49FGFR30.98715468
50RIPK10.96580604
51CHUK0.91671667
52MOS0.91334471
53CAMK1G0.87220370
54RPS6KA20.82417794
55ARAF0.79833461
56GRK70.78613984
57BTK0.78278075
58TRPM70.76347988
59EGFR0.75185302
60BMPR20.74229910
61TRIB30.73026662
62MST1R0.72856454
63TGFBR10.72463866
64ERBB30.71314535
65ABL10.71270719
66RPS6KL10.68592461
67RPS6KC10.68592461
68PRKCD0.68547325
69STK40.62271160
70PIM10.61842970
71DAPK20.58586852
72MAP3K90.58070376
73MAPK120.56460930
74ITK0.56405365
75EIF2AK20.56351467
76EPHA30.53830866
77MAP2K60.53228777
78MARK30.52431692
79TTN0.52023451
80PTK60.49915241
81EPHB20.49615311
82PRKCH0.49410713
83GRK10.47807087
84MAPK70.46448299
85PDGFRB0.46278574
86MAP2K30.44960037
87STK100.44623411
88ADRBK20.44277762
89MST40.43592790
90TEC0.42543468
91KDR0.41611484
92PDGFRA0.40644056
93FYN0.40471616
94MAP3K10.40330924
95MAP3K80.40058502
96TNK20.39408162
97MAP3K50.38386977
98IRAK20.38112189
99LRRK20.37365628
100PDPK10.36487294
101PAK40.35793755
102TESK10.33854941
103CDK60.33685788
104TYRO30.32734359
105KSR20.32731551
106PDK10.31272162
107DAPK30.30701962
108PRKCQ0.30144226
109MAP3K30.29224230
110MAP3K60.28779979
111YES10.28116693
112SRC0.26062842
113CAMKK10.25848568
114IGF1R0.24249258
115SIK30.23756396
116MAPKAPK20.22896463
117RPS6KA50.20891689
118CAMK1D0.19192033
119INSR0.17737650
120PRKG20.17515049
121RPS6KA60.17510511
122IRAK10.16724682
123ALK0.16380721
124CLK10.16180602
125ERBB40.16002914
126MAP3K110.15092825
127MAPK40.14826067
128GSK3A0.13886397

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.52788118
2Staphylococcus aureus infection_Homo sapiens_hsa051503.38449845
3Lysosome_Homo sapiens_hsa041422.98451063
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.97244350
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.57813211
6Tuberculosis_Homo sapiens_hsa051522.50036913
7Pertussis_Homo sapiens_hsa051332.49045513
8Malaria_Homo sapiens_hsa051442.48478241
9Osteoclast differentiation_Homo sapiens_hsa043802.44908706
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.31253209
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.26765665
12Rheumatoid arthritis_Homo sapiens_hsa053232.25330678
13Antigen processing and presentation_Homo sapiens_hsa046122.18648965
14Phagosome_Homo sapiens_hsa041452.17076815
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.15874354
16Graft-versus-host disease_Homo sapiens_hsa053322.13054541
17Legionellosis_Homo sapiens_hsa051342.04968620
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.91118304
19Measles_Homo sapiens_hsa051621.82945513
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72747818
21Other glycan degradation_Homo sapiens_hsa005111.72441006
22Influenza A_Homo sapiens_hsa051641.72127526
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69404433
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.69245298
25Salmonella infection_Homo sapiens_hsa051321.68298427
26Allograft rejection_Homo sapiens_hsa053301.65790727
27B cell receptor signaling pathway_Homo sapiens_hsa046621.64877880
28TNF signaling pathway_Homo sapiens_hsa046681.57620326
29Toxoplasmosis_Homo sapiens_hsa051451.53110886
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49505899
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48870785
32Herpes simplex infection_Homo sapiens_hsa051681.44243958
33African trypanosomiasis_Homo sapiens_hsa051431.42790371
34Chemokine signaling pathway_Homo sapiens_hsa040621.37648234
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37323895
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33668659
37Asthma_Homo sapiens_hsa053101.30154135
38Apoptosis_Homo sapiens_hsa042101.28846237
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25145027
40Collecting duct acid secretion_Homo sapiens_hsa049661.24874116
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22007676
42Primary immunodeficiency_Homo sapiens_hsa053401.21293063
43Complement and coagulation cascades_Homo sapiens_hsa046101.19591510
44Viral myocarditis_Homo sapiens_hsa054161.18379599
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16681821
46Shigellosis_Homo sapiens_hsa051311.16339211
47Hepatitis C_Homo sapiens_hsa051601.14486115
48Hematopoietic cell lineage_Homo sapiens_hsa046401.08920404
49Jak-STAT signaling pathway_Homo sapiens_hsa046301.00756247
50Amoebiasis_Homo sapiens_hsa051460.97990170
51Hepatitis B_Homo sapiens_hsa051610.96334010
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.91223118
53Type I diabetes mellitus_Homo sapiens_hsa049400.89573147
54Mineral absorption_Homo sapiens_hsa049780.83756802
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81207435
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80834210
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77452809
58Bladder cancer_Homo sapiens_hsa052190.75155953
59Prion diseases_Homo sapiens_hsa050200.70930632
60Autoimmune thyroid disease_Homo sapiens_hsa053200.67567458
61Sulfur metabolism_Homo sapiens_hsa009200.66413185
62Fructose and mannose metabolism_Homo sapiens_hsa000510.65898906
63Prolactin signaling pathway_Homo sapiens_hsa049170.62069544
64Sphingolipid metabolism_Homo sapiens_hsa006000.61973937
65T cell receptor signaling pathway_Homo sapiens_hsa046600.60361330
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.60221883
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60099501
68HIF-1 signaling pathway_Homo sapiens_hsa040660.57306911
69Platelet activation_Homo sapiens_hsa046110.55879193
70Vibrio cholerae infection_Homo sapiens_hsa051100.55298352
71Acute myeloid leukemia_Homo sapiens_hsa052210.53798058
72Arginine biosynthesis_Homo sapiens_hsa002200.52261811
73Caffeine metabolism_Homo sapiens_hsa002320.51622060
74Pancreatic cancer_Homo sapiens_hsa052120.50600241
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.48508676
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.47544833
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46917542
78Steroid biosynthesis_Homo sapiens_hsa001000.44999109
79Type II diabetes mellitus_Homo sapiens_hsa049300.44421113
80Synaptic vesicle cycle_Homo sapiens_hsa047210.43075764
81Pentose phosphate pathway_Homo sapiens_hsa000300.42631076
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41497947
83Chronic myeloid leukemia_Homo sapiens_hsa052200.38851335
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36111216
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35241091
86Epstein-Barr virus infection_Homo sapiens_hsa051690.34738575
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34435913
88VEGF signaling pathway_Homo sapiens_hsa043700.34057862
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34032027
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31759375
91Renin-angiotensin system_Homo sapiens_hsa046140.31238664
92Galactose metabolism_Homo sapiens_hsa000520.30059634
93Endocytosis_Homo sapiens_hsa041440.29483186
94ABC transporters_Homo sapiens_hsa020100.28551712
95GnRH signaling pathway_Homo sapiens_hsa049120.27770341
96Notch signaling pathway_Homo sapiens_hsa043300.27098444
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26362762
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.25347295
99Glutathione metabolism_Homo sapiens_hsa004800.24080230
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23903030
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.23465671
102Viral carcinogenesis_Homo sapiens_hsa052030.22702692
103Systemic lupus erythematosus_Homo sapiens_hsa053220.22079216
104Renal cell carcinoma_Homo sapiens_hsa052110.21066044
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.20997422
106PPAR signaling pathway_Homo sapiens_hsa033200.20840572
107Dorso-ventral axis formation_Homo sapiens_hsa043200.20455238
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19684746
109Small cell lung cancer_Homo sapiens_hsa052220.19333483
110Proteoglycans in cancer_Homo sapiens_hsa052050.19054625
111Proteasome_Homo sapiens_hsa030500.18907802
112HTLV-I infection_Homo sapiens_hsa051660.17516284
113Ether lipid metabolism_Homo sapiens_hsa005650.17479552
114Tryptophan metabolism_Homo sapiens_hsa003800.17406980
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16115387
116Estrogen signaling pathway_Homo sapiens_hsa049150.13507794

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