SLAMF9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the signaling lymphocytic activation molecule family. The encoded protein is a cell surface molecule that consists of two extracellular immunoglobulin domains, a transmembrane domain and a short cytoplasmic tail that lacks the signal transduction motifs found in other family members. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.82423396
2neutrophil activation involved in immune response (GO:0002283)5.57004552
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.52063721
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.52063721
5modulation by symbiont of host immune response (GO:0052553)5.52063721
6positive regulation by symbiont of host defense response (GO:0052509)5.52063721
7modulation by symbiont of host defense response (GO:0052031)5.52063721
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.52063721
9regulation of vitamin D biosynthetic process (GO:0060556)5.40864986
10positive regulation of interferon-alpha production (GO:0032727)5.39293747
11regulation of interferon-alpha production (GO:0032647)5.12443797
12response to peptidoglycan (GO:0032494)5.07969379
13immunoglobulin mediated immune response (GO:0016064)5.03459948
14negative regulation of interleukin-12 production (GO:0032695)4.68141956
15glycosphingolipid catabolic process (GO:0046479)4.57633754
16regulation of interferon-beta biosynthetic process (GO:0045357)4.43926373
17macrophage activation involved in immune response (GO:0002281)4.42730872
18oligosaccharide catabolic process (GO:0009313)4.30827469
19microglial cell activation (GO:0001774)4.28439856
20regulation of vitamin metabolic process (GO:0030656)4.26184592
21respiratory burst (GO:0045730)4.24426571
22cellular response to zinc ion (GO:0071294)4.16881886
23positive regulation of monocyte chemotaxis (GO:0090026)4.16744916
24eosinophil chemotaxis (GO:0048245)4.14224072
25positive regulation of type 2 immune response (GO:0002830)4.13241271
26glycolipid catabolic process (GO:0019377)4.10431303
27negative regulation of inflammatory response to antigenic stimulus (GO:0002862)4.09257157
28lipopolysaccharide-mediated signaling pathway (GO:0031663)4.03068629
29neutrophil activation (GO:0042119)4.00897280
30granulocyte activation (GO:0036230)4.00177421
31cellular response to exogenous dsRNA (GO:0071360)3.96512945
32cellular response to type I interferon (GO:0071357)3.95599493
33type I interferon signaling pathway (GO:0060337)3.95599493
34production of molecular mediator involved in inflammatory response (GO:0002532)3.94420085
35response to type I interferon (GO:0034340)3.93178173
36T-helper 1 type immune response (GO:0042088)3.91340414
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.89359523
38response to host immune response (GO:0052572)3.89359523
39lymphocyte chemotaxis (GO:0048247)3.89315652
40positive regulation of cellular amide metabolic process (GO:0034250)3.87708302
41positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.87419920
42regulation of mononuclear cell migration (GO:0071675)3.83608729
43regulation of cytokine secretion involved in immune response (GO:0002739)3.83349276
44B cell mediated immunity (GO:0019724)3.78025481
45positive regulation of NF-kappaB import into nucleus (GO:0042346)3.75094537
46positive regulation of antigen processing and presentation (GO:0002579)3.72809900
47positive regulation of interferon-beta production (GO:0032728)3.71454296
48regulation of dendritic cell antigen processing and presentation (GO:0002604)3.69104152
49positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.68715479
50ceramide catabolic process (GO:0046514)3.66329510
51regulation of activation of Janus kinase activity (GO:0010533)3.65649777
52decidualization (GO:0046697)3.65277906
53cellular response to thyroid hormone stimulus (GO:0097067)3.65046293
54response to interferon-alpha (GO:0035455)3.64257107
55eosinophil migration (GO:0072677)3.63295240
56cellular response to interferon-alpha (GO:0035457)3.62636718
57positive regulation of heat generation (GO:0031652)3.61769739
58positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.59487131
59hydrogen peroxide biosynthetic process (GO:0050665)3.57382606
60regulation of membrane protein ectodomain proteolysis (GO:0051043)3.55996343
61monocyte chemotaxis (GO:0002548)3.53374520
62interferon-gamma-mediated signaling pathway (GO:0060333)3.53139088
63T cell migration (GO:0072678)3.52320636
64myeloid cell activation involved in immune response (GO:0002275)3.52144103
65macrophage activation (GO:0042116)3.51660399
66positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.50159838
67positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.50050941
68negative regulation of nitric oxide biosynthetic process (GO:0045019)3.49500112
69defense response to protozoan (GO:0042832)3.48707758
70positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.48052513
71positive regulation of mast cell activation involved in immune response (GO:0033008)3.47586095
72positive regulation of mast cell degranulation (GO:0043306)3.47586095
73regulation of fever generation (GO:0031620)3.44912084
74response to host (GO:0075136)3.42745952
75response to host defenses (GO:0052200)3.42745952
76response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.42745952
77antigen processing and presentation of endogenous antigen (GO:0019883)3.41890874
78positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.40884472
79positive regulation of chemokine biosynthetic process (GO:0045080)3.39122165
80amino sugar catabolic process (GO:0046348)3.38224903
81regulation of T-helper 2 cell differentiation (GO:0045628)3.37662816
82response to muramyl dipeptide (GO:0032495)3.37306187
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.34062041
84positive regulation of interleukin-12 production (GO:0032735)3.33548662
85superoxide anion generation (GO:0042554)3.31004686
86regulation of monocyte chemotaxis (GO:0090025)3.30322003
87positive regulation of T-helper 1 type immune response (GO:0002827)3.27976273
88positive regulation of mast cell activation (GO:0033005)3.27102360
89regulation of interferon-gamma biosynthetic process (GO:0045072)3.26485362
90myeloid dendritic cell differentiation (GO:0043011)3.25587452
91negative regulation of interleukin-17 production (GO:0032700)3.25536846
92positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.25105713
93branching involved in labyrinthine layer morphogenesis (GO:0060670)3.23355125
94positive regulation of lymphocyte migration (GO:2000403)3.22677071
95regulation of T-helper cell differentiation (GO:0045622)3.21845893
96regulation of inflammatory response to antigenic stimulus (GO:0002861)3.20945518
97NIK/NF-kappaB signaling (GO:0038061)3.20934330
98cellular response to interferon-beta (GO:0035458)3.20721637
99positive regulation of tissue remodeling (GO:0034105)3.17416432
100positive regulation of natural killer cell activation (GO:0032816)3.17387223
101regulation of antigen processing and presentation (GO:0002577)3.17349842
102regulation of podosome assembly (GO:0071801)3.16796307
103negative regulation of viral genome replication (GO:0045071)3.16370918
104positive regulation of T cell migration (GO:2000406)3.16045214
105cellular response to cadmium ion (GO:0071276)3.15673440
106regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.15576353
107membrane lipid catabolic process (GO:0046466)3.13921957
108reactive oxygen species biosynthetic process (GO:1903409)3.11856006
109sexual reproduction (GO:0019953)3.10600337
110lymphocyte mediated immunity (GO:0002449)3.10286279
111leukocyte mediated cytotoxicity (GO:0001909)3.09151603
112response to protozoan (GO:0001562)3.08798359
113regulation of T-helper 1 cell differentiation (GO:0045625)3.08774927
114positive regulation of T-helper cell differentiation (GO:0045624)3.07692991
115regulation of interleukin-17 production (GO:0032660)3.07201230
116regulation of RIG-I signaling pathway (GO:0039535)3.07183709
117regulation of chemokine biosynthetic process (GO:0045073)3.06388019
118negative regulation of myeloid cell apoptotic process (GO:0033033)3.06180182
119regulation of memory T cell differentiation (GO:0043380)3.05761835
120positive regulation of interleukin-17 production (GO:0032740)3.05738595
121positive regulation of natural killer cell differentiation (GO:0032825)3.04461031
122positive regulation of macrophage cytokine production (GO:0060907)3.02445925
123sphingolipid catabolic process (GO:0030149)3.01857465
124regulation of cholesterol storage (GO:0010885)3.01385859
125negative regulation of interleukin-1 beta production (GO:0032691)2.99809085
126negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.99448195
127adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.99116412
128positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.98710226
129positive regulation of interleukin-10 production (GO:0032733)2.98491311
130myeloid dendritic cell activation (GO:0001773)2.98341844
131positive regulation of defense response to virus by host (GO:0002230)2.98278440
132natural killer cell mediated immunity (GO:0002228)2.97196627
133natural killer cell mediated cytotoxicity (GO:0042267)2.97196627
134positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.96491867
135regulation of chronic inflammatory response (GO:0002676)2.96289655
136positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.96145936
137cellular response to interferon-gamma (GO:0071346)2.96143470
138response to thyroid hormone (GO:0097066)2.96089064
139negative regulation of interleukin-10 production (GO:0032693)2.95538433
140myeloid leukocyte activation (GO:0002274)2.95130782
141positive regulation of tumor necrosis factor production (GO:0032760)2.95059064
142regulation of B cell receptor signaling pathway (GO:0050855)2.94736969
143response to interferon-beta (GO:0035456)2.94628683
144cellular response to lipopolysaccharide (GO:0071222)2.92158743
145adhesion of symbiont to host cell (GO:0044650)2.89005758
146virion attachment to host cell (GO:0019062)2.89005758
147negative regulation of cytokine production involved in immune response (GO:0002719)2.88972679
148regulation of interleukin-12 production (GO:0032655)2.88764971
149regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.88308830
150regulation of nitric oxide biosynthetic process (GO:0045428)2.83775841
151cellular response to molecule of bacterial origin (GO:0071219)2.81230071
152positive regulation of osteoclast differentiation (GO:0045672)2.78338261
153fat-soluble vitamin biosynthetic process (GO:0042362)2.77527267
154regulation of growth of symbiont in host (GO:0044126)2.77136376
155negative regulation of growth of symbiont in host (GO:0044130)2.77136376
156negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.77136376
157modulation of growth of symbiont involved in interaction with host (GO:0044144)2.77136376
158regulation of T-helper 1 type immune response (GO:0002825)2.73995074
159regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.71686832
160regulation of NF-kappaB import into nucleus (GO:0042345)2.68965165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.72247631
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.67169441
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.60487718
4* IRF8_27001747_Chip-Seq_BMDM_Mouse5.08790407
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.79960688
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.49314988
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.28202038
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.96375003
9* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.73202193
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.57050159
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.15015740
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.05126402
13* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.99549811
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79488104
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.77149301
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.64284994
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.61989272
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.61605913
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55156805
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47052107
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.13724336
22SPI1_23547873_ChIP-Seq_NB4_Human2.02606697
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92057391
24* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.84281837
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.83464694
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78079303
27* PU_27001747_Chip-Seq_BMDM_Mouse1.71657157
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71349119
29* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69825981
30* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66071585
31VDR_24787735_ChIP-Seq_THP-1_Human1.61896067
32SPI1_23127762_ChIP-Seq_K562_Human1.61191168
33VDR_24763502_ChIP-Seq_THP-1_Human1.59307142
34* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58321340
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.56357918
36MYB_26560356_Chip-Seq_TH2_Human1.53103494
37TFEB_21752829_ChIP-Seq_HELA_Human1.49691613
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.48190414
39GATA1_22025678_ChIP-Seq_K562_Human1.47836213
40* LXR_22292898_ChIP-Seq_THP-1_Human1.46332319
41* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43929796
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43354094
43RUNX_20019798_ChIP-Seq_JUKART_Human1.42833376
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.42372899
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41997870
46* MAF_26560356_Chip-Seq_TH1_Human1.38272609
47* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38021673
48* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36624738
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36051214
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.31979700
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30712918
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28651105
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.25585612
54FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24294607
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20115730
56MYB_26560356_Chip-Seq_TH1_Human1.19886942
57TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17240376
58SCL_19346495_ChIP-Seq_HPC-7_Human1.17149448
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16853107
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16735854
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16702512
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16547447
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16199994
64* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13850769
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13543554
66* GATA3_26560356_Chip-Seq_TH2_Human1.13355125
67EGR1_19032775_ChIP-ChIP_M12_Human1.12614122
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.12580933
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12470632
70FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11773950
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.08607022
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08459429
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07753161
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06337815
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05158995
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04785602
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04173363
78CLOCK_20551151_ChIP-Seq_293T_Human1.03466696
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00858723
80STAT1_20625510_ChIP-Seq_HELA_Human1.00802003
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00689574
82* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99463389
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99399700
84CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99326992
85IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99170350
86GATA3_27048872_Chip-Seq_THYMUS_Human0.99088295
87KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98728632
88KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97631418
89* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97514117
90VDR_21846776_ChIP-Seq_THP-1_Human0.96780816
91UBF1/2_26484160_Chip-Seq_HMECs_Human0.96518050
92ATF3_27146783_Chip-Seq_COLON_Human0.94168974
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93773907
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93537452
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93328590
96ZNF263_19887448_ChIP-Seq_K562_Human0.93153626
97RACK7_27058665_Chip-Seq_MCF-7_Human0.93090977
98CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92715828
99GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91323894
100PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90883471
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90140166
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89845766
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89845766
104SOX2_20726797_ChIP-Seq_SW620_Human0.89683692
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89654892
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80255772
107TRIM28_21343339_ChIP-Seq_HEK293_Human0.77717332
108SPI1_20517297_ChIP-Seq_HL60_Human0.77363797
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75534873
110UTX_26944678_Chip-Seq_JUKART_Human0.74664824
111EGR1_23403033_ChIP-Seq_LIVER_Mouse0.73910434
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72077886
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69830818
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.69608300
115RARG_19884340_ChIP-ChIP_MEFs_Mouse0.67624596
116CJUN_26792858_Chip-Seq_BT549_Human0.66421666
117* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65745706
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.64882424
119GATA1_19941826_ChIP-Seq_K562_Human0.64689383
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62997041
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.62210240
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.62117457
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61597907
124GATA2_19941826_ChIP-Seq_K562_Human0.61488522
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.60880002
126MAF_26560356_Chip-Seq_TH2_Human0.60572156
127* SMRT_27268052_Chip-Seq_Bcells_Human0.58739698
128SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.57432843
129SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.57432843
130* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.55979484
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.54657332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.32128600
2MP0002148_abnormal_hypersensitivity_rea4.20410234
3MP0003436_decreased_susceptibility_to4.11037117
4MP0009785_altered_susceptibility_to4.05696055
5MP0005058_abnormal_lysosome_morphology3.45165092
6MP0006082_CNS_inflammation3.39502971
7MP0005000_abnormal_immune_tolerance3.34622488
8MP0002419_abnormal_innate_immunity3.32908690
9MP0005671_abnormal_response_to3.28257540
10MP0005025_abnormal_response_to3.15308742
11MP0001790_abnormal_immune_system3.07348952
12MP0005387_immune_system_phenotype3.07348952
13MP0003303_peritoneal_inflammation2.92257163
14MP0003724_increased_susceptibility_to2.92134920
15MP0000685_abnormal_immune_system2.79129541
16MP0004510_myositis2.72541789
17MP0002452_abnormal_antigen_presenting2.70866275
18MP0001800_abnormal_humoral_immune2.65404132
19MP0002723_abnormal_immune_serum2.55142679
20MP0002139_abnormal_hepatobiliary_system2.31334675
21MP0001533_abnormal_skeleton_physiology2.28240400
22MP0005451_abnormal_body_composition2.24854170
23MP0001819_abnormal_immune_cell2.22068327
24MP0002420_abnormal_adaptive_immunity2.17817228
25MP0009840_abnormal_foam_cell2.17377572
26MP0003806_abnormal_nucleotide_metabolis2.10399054
27MP0009764_decreased_sensitivity_to1.96651545
28MP0001845_abnormal_inflammatory_respons1.93207295
29MP0001853_heart_inflammation1.90266836
30MP0005464_abnormal_platelet_physiology1.87669277
31MP0002405_respiratory_system_inflammati1.84219815
32MP0003075_altered_response_to1.83394174
33MP0008469_abnormal_protein_level1.81832713
34MP0005310_abnormal_salivary_gland1.80888948
35MP0000343_altered_response_to1.80029874
36MP0010155_abnormal_intestine_physiology1.68632072
37MP0004947_skin_inflammation1.68027131
38MP0003448_altered_tumor_morphology1.66461486
39MP0006054_spinal_hemorrhage1.63750380
40MP0003950_abnormal_plasma_membrane1.62555418
41MP0003191_abnormal_cellular_cholesterol1.61252392
42MP0009333_abnormal_splenocyte_physiolog1.58756117
43MP0008260_abnormal_autophagy1.58271427
44MP0003690_abnormal_glial_cell1.57131894
45MP0002006_tumorigenesis1.50887680
46MP0000716_abnormal_immune_system1.50179692
47MP0002998_abnormal_bone_remodeling1.46607718
48MP0003172_abnormal_lysosome_physiology1.42340374
49MP0005166_decreased_susceptibility_to1.42206784
50MP0003656_abnormal_erythrocyte_physiolo1.40672056
51MP0000604_amyloidosis1.39350592
52MP0005167_abnormal_blood-brain_barrier1.38939893
53MP0004782_abnormal_surfactant_physiolog1.36826759
54MP0002398_abnormal_bone_marrow1.33554212
55MP0000858_altered_metastatic_potential1.32794249
56MP0005023_abnormal_wound_healing1.29682829
57MP0002277_abnormal_respiratory_mucosa1.28292833
58MP0002837_dystrophic_cardiac_calcinosis1.24178118
59MP0009278_abnormal_bone_marrow1.23877563
60MP0002166_altered_tumor_susceptibility1.21760799
61MP0002429_abnormal_blood_cell1.16190416
62MP0000689_abnormal_spleen_morphology1.14977478
63MP0009763_increased_sensitivity_to1.11701607
64MP0002138_abnormal_hepatobiliary_system1.11279772
65MP0003329_amyloid_beta_deposits1.11108968
66MP0005164_abnormal_response_to1.09526667
67MP0003828_pulmonary_edema1.07119001
68MP0005390_skeleton_phenotype1.06040377
69MP0010234_abnormal_vibrissa_follicle1.05400367
70MP0009765_abnormal_xenobiotic_induced1.05328150
71MP0001545_abnormal_hematopoietic_system1.04821763
72MP0005397_hematopoietic_system_phenotyp1.04821763
73MP0002722_abnormal_immune_system1.02637281
74MP0005165_increased_susceptibility_to0.99227345
75MP0003186_abnormal_redox_activity0.96011674
76MP0000371_diluted_coat_color0.90337116
77MP0005666_abnormal_adipose_tissue0.89077794
78MP0002877_abnormal_melanocyte_morpholog0.88764729
79MP0005410_abnormal_fertilization0.87900825
80MP0003646_muscle_fatigue0.86327008
81MP0010307_abnormal_tumor_latency0.81784954
82MP0005076_abnormal_cell_differentiation0.79928744
83MP0000249_abnormal_blood_vessel0.79791825
84MP0001727_abnormal_embryo_implantation0.79593166
85MP0003300_gastrointestinal_ulcer0.77833056
86MP0002136_abnormal_kidney_physiology0.75063634
87MP0004883_abnormal_blood_vessel0.72769200
88MP0008004_abnormal_stomach_pH0.72443936
89MP0001851_eye_inflammation0.72346308
90MP0001849_ear_inflammation0.70459277
91MP0001216_abnormal_epidermal_layer0.69282352
92MP0002254_reproductive_system_inflammat0.69148978
93MP0005257_abnormal_intraocular_pressure0.68679977
94MP0002933_joint_inflammation0.68078174
95MP0005647_abnormal_sex_gland0.67553962
96MP0000569_abnormal_digit_pigmentation0.66966583
97MP0008874_decreased_physiological_sensi0.65957853
98MP0010352_gastrointestinal_tract_polyps0.64582300
99MP0003566_abnormal_cell_adhesion0.64465176
100MP0003705_abnormal_hypodermis_morpholog0.64057894
101MP0008438_abnormal_cutaneous_collagen0.64039745
102MP0003195_calcinosis0.63500283
103MP0003795_abnormal_bone_structure0.63142244
104MP0000920_abnormal_myelination0.61445036
105MP0003634_abnormal_glial_cell0.61330291
106MP0003183_abnormal_peptide_metabolism0.61297349
107MP0005375_adipose_tissue_phenotype0.60082777
108MP0002295_abnormal_pulmonary_circulatio0.58738486
109MP0005595_abnormal_vascular_smooth0.58378519
110MP0010386_abnormal_urinary_bladder0.56798963
111MP0003763_abnormal_thymus_physiology0.55647552
112MP0005174_abnormal_tail_pigmentation0.54828059
113MP0003279_aneurysm0.54234802
114MP0000609_abnormal_liver_physiology0.51539827
115MP0000767_abnormal_smooth_muscle0.50583673
116MP0008873_increased_physiological_sensi0.49815182
117MP0002332_abnormal_exercise_endurance0.49425763
118MP0005584_abnormal_enzyme/coenzyme_acti0.48861043
119MP0003091_abnormal_cell_migration0.48370387
120MP0003453_abnormal_keratinocyte_physiol0.48215266
121MP0001542_abnormal_bone_strength0.47450947
122MP0005319_abnormal_enzyme/_coenzyme0.47281549
123MP0004130_abnormal_muscle_cell0.46825560
124MP0002693_abnormal_pancreas_physiology0.45077466
125MP0002090_abnormal_vision0.44848487
126MP0004808_abnormal_hematopoietic_stem0.44564851
127MP0001873_stomach_inflammation0.43606960
128MP0000465_gastrointestinal_hemorrhage0.42769792

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.81660313
2Recurrent bacterial skin infections (HP:0005406)7.39177000
3Systemic lupus erythematosus (HP:0002725)7.09611061
4Eczematoid dermatitis (HP:0000976)6.82461852
5Recurrent gram-negative bacterial infections (HP:0005420)5.76710058
6Mediastinal lymphadenopathy (HP:0100721)4.91103205
7Glomerulonephritis (HP:0000099)4.85506964
8Abnormality of macrophages (HP:0004311)4.67344001
9Recurrent skin infections (HP:0001581)4.41555786
10Gingivitis (HP:0000230)4.35665238
11Vacuolated lymphocytes (HP:0001922)4.33026995
12Autoimmune thrombocytopenia (HP:0001973)4.30965790
13Thick nail (HP:0001805)4.08739215
14Elevated erythrocyte sedimentation rate (HP:0003565)3.80539936
15Pustule (HP:0200039)3.80444978
16Increased cerebral lipofuscin (HP:0011813)3.68551606
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.62206469
18Abnormality of complement system (HP:0005339)3.58189345
19Stomatitis (HP:0010280)3.57189308
20Recurrent fungal infections (HP:0002841)3.55797661
21Neurofibrillary tangles (HP:0002185)3.50196179
22Increased IgM level (HP:0003496)3.48172443
23Mutism (HP:0002300)3.48031227
24Prostate neoplasm (HP:0100787)3.47565403
25Axonal loss (HP:0003447)3.46101935
26Chronic obstructive pulmonary disease (HP:0006510)3.44844294
27Obstructive lung disease (HP:0006536)3.44844294
28Recurrent viral infections (HP:0004429)3.40330326
29Basal ganglia calcification (HP:0002135)3.37927317
30Disinhibition (HP:0000734)3.36621967
31Periodontitis (HP:0000704)3.34972649
32Nuclear cataract (HP:0100018)3.33991973
33Osteolytic defects of the hand bones (HP:0009699)3.31954650
34Osteolytic defects of the phalanges of the hand (HP:0009771)3.31954650
35Abnormality of liposaccharide metabolism (HP:0010968)3.25961784
36Abnormality of glycosphingolipid metabolism (HP:0004343)3.25961784
37Abnormality of glycolipid metabolism (HP:0010969)3.25961784
38Complement deficiency (HP:0004431)3.23667402
39Vasculitis (HP:0002633)3.23529935
40Nephritis (HP:0000123)3.22165489
41Dysostosis multiplex (HP:0000943)3.21068652
42Gastrointestinal infarctions (HP:0005244)3.20490962
43Myositis (HP:0100614)3.19947453
44Orchitis (HP:0100796)3.19844280
45Cellulitis (HP:0100658)3.18047894
46Apathy (HP:0000741)3.16984964
47Interstitial pulmonary disease (HP:0006530)3.12207675
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.12185384
49Diminished motivation (HP:0000745)3.11756477
50Metaphyseal irregularity (HP:0003025)3.09855741
51Retrobulbar optic neuritis (HP:0100654)3.00446028
52Optic neuritis (HP:0100653)3.00446028
53Increased serum ferritin (HP:0003281)2.97994462
54Recurrent pneumonia (HP:0006532)2.87292094
55Chronic mucocutaneous candidiasis (HP:0002728)2.80673446
56Recurrent cutaneous fungal infections (HP:0011370)2.80673446
57Premature loss of primary teeth (HP:0006323)2.75688850
58Urticaria (HP:0001025)2.71866496
59Pulmonary infiltrates (HP:0002113)2.67988593
60Osteomyelitis (HP:0002754)2.67582536
61Recurrent lower respiratory tract infections (HP:0002783)2.57235869
62Meningitis (HP:0001287)2.56711411
63Amyloidosis (HP:0011034)2.54198693
64Tetraparesis (HP:0002273)2.52769346
65Hypergammaglobulinemia (HP:0010702)2.50707771
66Colitis (HP:0002583)2.45266007
67Myocardial infarction (HP:0001658)2.40115997
68Petechiae (HP:0000967)2.39977435
69Progressive visual loss (HP:0000529)2.38654629
70Hepatosplenomegaly (HP:0001433)2.37628579
71Poor head control (HP:0002421)2.37374881
72Cerebral inclusion bodies (HP:0100314)2.37247913
73Progressive neurologic deterioration (HP:0002344)2.37177450
74Agnosia (HP:0010524)2.36934661
75Neuronal loss in central nervous system (HP:0002529)2.33699709
76Purpura (HP:0000979)2.31920353
77Joint hemorrhage (HP:0005261)2.28676777
78Protuberant abdomen (HP:0001538)2.26310793
79Gangrene (HP:0100758)2.26285271
80Spontaneous hematomas (HP:0007420)2.25865150
81Thin bony cortex (HP:0002753)2.25512396
82Hematochezia (HP:0002573)2.23343002
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22358958
84Abnormality of iron homeostasis (HP:0011031)2.22089850
85Mucopolysacchariduria (HP:0008155)2.21737748
86Urinary glycosaminoglycan excretion (HP:0003541)2.21737748
87Abnormality of the costochondral junction (HP:0000919)2.21609849
88Chronic otitis media (HP:0000389)2.21347509
89Bone pain (HP:0002653)2.17371295
90Leukocytosis (HP:0001974)2.16330779
91Arterial thrombosis (HP:0004420)2.15530590
92Generalized aminoaciduria (HP:0002909)2.13732853
93Asymmetric septal hypertrophy (HP:0001670)2.12770979
94Abnormality of the prostate (HP:0008775)2.12539034
95Hypertensive crisis (HP:0100735)2.10128556
96Agammaglobulinemia (HP:0004432)2.09646212
97Eosinophilia (HP:0001880)2.09449456
98Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09033887
99Hemoptysis (HP:0002105)2.07753823
100Inappropriate behavior (HP:0000719)2.07248207
101Pathologic fracture (HP:0002756)2.06076836
102Abnormal delayed hypersensitivity skin test (HP:0002963)2.04954947
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02946003
104Abnormality of polysaccharide metabolism (HP:0011012)2.02946003
105Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02946003
106Dementia (HP:0000726)2.01593470
107Supranuclear gaze palsy (HP:0000605)1.98215293
108Skin ulcer (HP:0200042)1.97804073
109Personality changes (HP:0000751)1.96417033
110Keratoconjunctivitis sicca (HP:0001097)1.96204051
111Prolonged neonatal jaundice (HP:0006579)1.96095169
112Amaurosis fugax (HP:0100576)1.95860077
113Gingival bleeding (HP:0000225)1.94889981
114Upper motor neuron abnormality (HP:0002127)1.93264415
115Anorexia (HP:0002039)1.90505369
116Polyneuropathy (HP:0001271)1.90163480
117Inflammation of the large intestine (HP:0002037)1.89505737
118Retinal atrophy (HP:0001105)1.88723725
119Peripheral demyelination (HP:0011096)1.88386421
120Neoplasm of head and neck (HP:0012288)1.85948545
121Esophageal neoplasm (HP:0100751)1.85948545
122Sepsis (HP:0100806)1.83873664
123Abnormality of the vasculature of the conjunctiva (HP:0008054)1.83431211
124Arthralgia (HP:0002829)1.81893519
125Nausea (HP:0002018)1.81055841
126Abnormality of the pericardium (HP:0001697)1.79534185
127Joint swelling (HP:0001386)1.78733166
128Autoimmune hemolytic anemia (HP:0001890)1.78367392
129Vertebral compression fractures (HP:0002953)1.77526945
130Cardiomegaly (HP:0001640)1.76873028
131Loss of speech (HP:0002371)1.76781970
132Glomerulopathy (HP:0100820)1.76189684
133Abnormality of transition element cation homeostasis (HP:0011030)1.75808040
134J-shaped sella turcica (HP:0002680)1.75089150
135Xanthomatosis (HP:0000991)1.74484277
136Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.70749605
137Keratoconjunctivitis (HP:0001096)1.70703422
138Cervical subluxation (HP:0003308)1.70348458
139Hyperparathyroidism (HP:0000843)1.69360679
140Cutaneous melanoma (HP:0012056)1.65509174
141Conjunctival telangiectasia (HP:0000524)1.63369975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.86389848
2RIPK44.31400351
3DDR24.05412561
4TYK23.96614245
5TBK13.54871940
6BLK3.49923033
7PBK3.14666654
8IRAK43.02058628
9IKBKE2.70841336
10IRAK32.58417723
11IKBKB2.49392519
12JAK12.38298208
13JAK32.32076404
14ERN12.14077607
15TGFBR22.12529898
16MAP4K12.05113823
17TXK1.98323155
18PIM21.96021737
19MAP3K91.94849724
20KIT1.84925064
21GRK71.83561466
22STK241.65705787
23HCK1.64404957
24PRPF4B1.63117835
25BMPR21.62486628
26CSK1.59687244
27CHUK1.50704171
28SYK1.46076032
29MAP3K131.43735985
30NEK91.42949295
31MST41.39357505
32BTK1.39340363
33EIF2AK21.38748958
34LYN1.36068186
35CSF1R1.35562379
36NME21.30941585
37JAK21.30896259
38TEC1.29880905
39EPHB11.27401825
40ZAP701.23769427
41FGR1.13924550
42TESK11.12289564
43CDC42BPA1.11437616
44YES11.06557161
45EPHB21.06238475
46ABL21.04966463
47KSR21.01696667
48MATK1.01046058
49LCK1.00001399
50PIM10.96162446
51LATS20.95802205
52ACVR1B0.95794429
53MAP3K50.92511219
54CLK10.90387024
55STK100.85331163
56PAK40.84371833
57ADRBK20.83937296
58FES0.83351759
59FGFR40.83254795
60ARAF0.83024610
61BMX0.82758986
62TAOK30.81310886
63PRKCD0.79675801
64LIMK10.79444285
65PDGFRA0.78557172
66RIPK10.77492960
67STK40.75762147
68MAP2K30.74945479
69EPHA30.74291357
70ITK0.73905090
71MAP3K110.72706113
72MARK30.70022094
73BRAF0.69028723
74MOS0.66293716
75PKN20.61627784
76EGFR0.60652621
77RAF10.57952274
78ABL10.57811141
79MAP3K30.56091117
80ERBB30.54851964
81FGFR30.54566001
82TESK20.54326608
83CAMKK20.53509969
84MAP3K10.53468375
85TRPM70.53030832
86PRKCQ0.51863458
87ILK0.50952180
88IRAK10.49832872
89MST1R0.49541091
90GSK3A0.46848821
91KSR10.46000756
92TRIB30.45017211
93MAP2K60.44704044
94TAOK20.44240711
95CDK60.43513156
96MAPKAPK20.42348539
97RPS6KA40.42144035
98ICK0.41420215
99PIK3CG0.37061554
100DAPK30.36840673
101MAP3K100.34563769
102PDK20.33494396
103DYRK1B0.33449913
104MAP3K120.33355775
105MAP3K80.32826768
106IGF1R0.32410048
107PAK10.31672576
108TAOK10.31195206
109RPS6KL10.30415656
110RPS6KC10.30415656
111BCKDK0.29751616
112CAMKK10.29294615
113SIK30.29105349
114TYRO30.27646554
115CDK180.26695832
116TTN0.26259131
117CDK150.26072109
118TGFBR10.24342058
119FYN0.23521243
120CDK11A0.23440001
121CDK140.23410743
122LRRK20.22151178
123IRAK20.21411456
124PDK10.20860808
125INSR0.20212458
126PKN10.19562154
127SIK20.19478665
128RPS6KA60.18394919
129CAMK1D0.17544077
130STK30.17275433
131PDPK10.16558555
132SRC0.15402551
133MAPK40.14934998
134PDGFRB0.13067135

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.02905483
2Graft-versus-host disease_Homo sapiens_hsa053323.41157656
3Allograft rejection_Homo sapiens_hsa053303.33684190
4Leishmaniasis_Homo sapiens_hsa051403.22103453
5Toll-like receptor signaling pathway_Homo sapiens_hsa046203.01232080
6Pertussis_Homo sapiens_hsa051332.57012423
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.53579789
8Legionellosis_Homo sapiens_hsa051342.51051086
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.43998413
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.35189994
11Osteoclast differentiation_Homo sapiens_hsa043802.28307261
12Malaria_Homo sapiens_hsa051442.27052144
13Rheumatoid arthritis_Homo sapiens_hsa053232.18336408
14Type I diabetes mellitus_Homo sapiens_hsa049402.16265495
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.14723407
16Tuberculosis_Homo sapiens_hsa051522.14590688
17Measles_Homo sapiens_hsa051622.09409638
18Asthma_Homo sapiens_hsa053102.06948403
19Lysosome_Homo sapiens_hsa041422.03468280
20NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02313083
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95323228
22African trypanosomiasis_Homo sapiens_hsa051431.93321063
23Influenza A_Homo sapiens_hsa051641.91435997
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.65265245
25Toxoplasmosis_Homo sapiens_hsa051451.65189026
26Autoimmune thyroid disease_Homo sapiens_hsa053201.62214125
27Phagosome_Homo sapiens_hsa041451.62211237
28Salmonella infection_Homo sapiens_hsa051321.61567026
29TNF signaling pathway_Homo sapiens_hsa046681.61494402
30B cell receptor signaling pathway_Homo sapiens_hsa046621.57858967
31Antigen processing and presentation_Homo sapiens_hsa046121.54626683
32Herpes simplex infection_Homo sapiens_hsa051681.52010625
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50696137
34Other glycan degradation_Homo sapiens_hsa005111.50415481
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.48677964
36Chemokine signaling pathway_Homo sapiens_hsa040621.40904396
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.39122768
38Prion diseases_Homo sapiens_hsa050201.36413560
39Apoptosis_Homo sapiens_hsa042101.35599205
40Hematopoietic cell lineage_Homo sapiens_hsa046401.26046334
41Sulfur metabolism_Homo sapiens_hsa009201.24849263
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23563338
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.19911038
44Viral myocarditis_Homo sapiens_hsa054161.19310595
45Shigellosis_Homo sapiens_hsa051311.13482174
46Complement and coagulation cascades_Homo sapiens_hsa046101.13316598
47Primary immunodeficiency_Homo sapiens_hsa053401.09318722
48Galactose metabolism_Homo sapiens_hsa000521.02425889
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02166167
50Bladder cancer_Homo sapiens_hsa052190.97214284
51Hepatitis C_Homo sapiens_hsa051600.95937849
52Hepatitis B_Homo sapiens_hsa051610.93173330
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88948229
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88032496
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85902450
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84010750
57Amoebiasis_Homo sapiens_hsa051460.84004551
58Fructose and mannose metabolism_Homo sapiens_hsa000510.80327840
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78987461
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.74185343
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73557027
62T cell receptor signaling pathway_Homo sapiens_hsa046600.65779454
63PPAR signaling pathway_Homo sapiens_hsa033200.62254971
64Caffeine metabolism_Homo sapiens_hsa002320.58036348
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54173458
66Prolactin signaling pathway_Homo sapiens_hsa049170.49099375
67Chronic myeloid leukemia_Homo sapiens_hsa052200.46438057
68Pentose phosphate pathway_Homo sapiens_hsa000300.46422277
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46273209
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46138643
71Acute myeloid leukemia_Homo sapiens_hsa052210.45829792
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44681180
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43198111
74Collecting duct acid secretion_Homo sapiens_hsa049660.42915564
75Mineral absorption_Homo sapiens_hsa049780.42690483
76Pancreatic cancer_Homo sapiens_hsa052120.42191202
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.42070115
78Platelet activation_Homo sapiens_hsa046110.41542573
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.40239985
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40217173
81Synaptic vesicle cycle_Homo sapiens_hsa047210.39384079
82Renin-angiotensin system_Homo sapiens_hsa046140.38252870
83Glutathione metabolism_Homo sapiens_hsa004800.37363843
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.36110774
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36040892
86Epstein-Barr virus infection_Homo sapiens_hsa051690.35182796
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32477935
88Endocytosis_Homo sapiens_hsa041440.32009376
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.31726651
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30014685
91HIF-1 signaling pathway_Homo sapiens_hsa040660.24973933
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22904204
93Viral carcinogenesis_Homo sapiens_hsa052030.22803386
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22645597
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22351834
96Ether lipid metabolism_Homo sapiens_hsa005650.21102566
97Arachidonic acid metabolism_Homo sapiens_hsa005900.21030595
98Systemic lupus erythematosus_Homo sapiens_hsa053220.19778468
99Proteoglycans in cancer_Homo sapiens_hsa052050.19041777
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17637640
101Steroid biosynthesis_Homo sapiens_hsa001000.16830642
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14905601
103Tryptophan metabolism_Homo sapiens_hsa003800.14686832
104Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14399906
105Renal cell carcinoma_Homo sapiens_hsa052110.13899496
106VEGF signaling pathway_Homo sapiens_hsa043700.13852038
107Type II diabetes mellitus_Homo sapiens_hsa049300.13429916
108Sphingolipid metabolism_Homo sapiens_hsa006000.12739981
109Vibrio cholerae infection_Homo sapiens_hsa051100.12598353
110HTLV-I infection_Homo sapiens_hsa051660.12292979
111Small cell lung cancer_Homo sapiens_hsa052220.10019913
112Insulin resistance_Homo sapiens_hsa049310.08029071
113FoxO signaling pathway_Homo sapiens_hsa040680.07441514
114Notch signaling pathway_Homo sapiens_hsa043300.01994350
115MAPK signaling pathway_Homo sapiens_hsa040100.01696211

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