SLBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication checkpoint (GO:0000076)5.40768648
2eosinophil chemotaxis (GO:0048245)5.21396372
3CENP-A containing nucleosome assembly (GO:0034080)5.08618492
4chromatin remodeling at centromere (GO:0031055)4.98174137
5DNA strand elongation involved in DNA replication (GO:0006271)4.83203841
6DNA replication initiation (GO:0006270)4.80056727
7deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.79635658
8telomere maintenance via semi-conservative replication (GO:0032201)4.64302473
9kinetochore organization (GO:0051383)4.63428944
10eosinophil migration (GO:0072677)4.62506716
11mitotic metaphase plate congression (GO:0007080)4.59054569
12mitotic chromosome condensation (GO:0007076)4.57787836
13DNA strand elongation (GO:0022616)4.57088252
14attachment of spindle microtubules to kinetochore (GO:0008608)4.54808489
15DNA replication-independent nucleosome assembly (GO:0006336)4.44650615
16DNA replication-independent nucleosome organization (GO:0034724)4.44650615
17telomere maintenance via recombination (GO:0000722)4.25188853
18histone exchange (GO:0043486)4.24836322
19folic acid-containing compound biosynthetic process (GO:0009396)4.24326046
20meiotic chromosome segregation (GO:0045132)4.16557078
21protein localization to kinetochore (GO:0034501)4.14565283
22metaphase plate congression (GO:0051310)4.08401131
23kinetochore assembly (GO:0051382)4.06233279
24proteasome assembly (GO:0043248)4.05930079
25deoxyribose phosphate biosynthetic process (GO:0046385)4.04338029
262-deoxyribonucleotide biosynthetic process (GO:0009265)4.04338029
27establishment of integrated proviral latency (GO:0075713)4.01826944
28mitotic recombination (GO:0006312)4.00187429
29mitotic sister chromatid segregation (GO:0000070)3.99437150
30DNA replication-dependent nucleosome assembly (GO:0006335)3.96556350
31DNA replication-dependent nucleosome organization (GO:0034723)3.96556350
32maturation of 5.8S rRNA (GO:0000460)3.92073658
33pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.91462285
34piRNA metabolic process (GO:0034587)3.90017245
35DNA unwinding involved in DNA replication (GO:0006268)3.87446991
36nuclear pore complex assembly (GO:0051292)3.84121680
37establishment of chromosome localization (GO:0051303)3.84052536
38nucleotide-excision repair, DNA gap filling (GO:0006297)3.73193867
39regulation of double-strand break repair via homologous recombination (GO:0010569)3.72593699
40telomere maintenance via telomere lengthening (GO:0010833)3.71893697
41protein localization to chromosome, centromeric region (GO:0071459)3.68956187
42negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.63435181
43rRNA modification (GO:0000154)3.60335847
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.55293607
45maturation of SSU-rRNA (GO:0030490)3.54777505
46nucleobase-containing small molecule interconversion (GO:0015949)3.54697564
47ribosomal small subunit biogenesis (GO:0042274)3.52880421
48purine nucleobase biosynthetic process (GO:0009113)3.52027355
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.49991494
50protein K6-linked ubiquitination (GO:0085020)3.45656263
51dopamine transport (GO:0015872)3.39023439
52protein maturation by protein folding (GO:0022417)3.38012429
53ribosome biogenesis (GO:0042254)3.37869712
54mitotic sister chromatid cohesion (GO:0007064)3.37067903
55meiotic cell cycle (GO:0051321)3.36290361
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.36118663
57DNA methylation involved in gamete generation (GO:0043046)3.35628274
58sister chromatid segregation (GO:0000819)3.34652164
59rRNA methylation (GO:0031167)3.30073728
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30008809
61DNA synthesis involved in DNA repair (GO:0000731)3.29626663
62positive regulation of chromosome segregation (GO:0051984)3.29576236
63negative regulation of mRNA processing (GO:0050686)3.29397065
64base-excision repair (GO:0006284)3.28264065
65transcription-coupled nucleotide-excision repair (GO:0006283)3.26696117
66formation of translation preinitiation complex (GO:0001731)3.26445598
67translesion synthesis (GO:0019985)3.25709355
68IMP biosynthetic process (GO:0006188)3.24819899
69female gamete generation (GO:0007292)3.24521009
70viral transcription (GO:0019083)3.23322419
71regulation of mitochondrial translation (GO:0070129)3.23069210
72translational termination (GO:0006415)3.21894397
73DNA ligation (GO:0006266)3.21879524
747-methylguanosine mRNA capping (GO:0006370)3.20975990
75nucleobase biosynthetic process (GO:0046112)3.18621571
767-methylguanosine RNA capping (GO:0009452)3.18531077
77RNA capping (GO:0036260)3.18531077
78ribonucleoprotein complex biogenesis (GO:0022613)3.16763415
79chromatin assembly or disassembly (GO:0006333)3.16386962
80pyrimidine nucleotide catabolic process (GO:0006244)3.13351264
81cell cycle G1/S phase transition (GO:0044843)3.13341033
82G1/S transition of mitotic cell cycle (GO:0000082)3.13341033
83pore complex assembly (GO:0046931)3.13316244
84pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.11833204
85chromosome segregation (GO:0007059)3.11598945
86microtubule polymerization or depolymerization (GO:0031109)3.09499131
87establishment of viral latency (GO:0019043)3.08987980
88spindle checkpoint (GO:0031577)3.08966709
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.08806762
90negative regulation of meiosis (GO:0045835)3.06029604
91DNA deamination (GO:0045006)3.04682585
92rRNA processing (GO:0006364)3.04345420
93spliceosomal snRNP assembly (GO:0000387)3.04223798
94negative regulation of RNA splicing (GO:0033119)3.03547621
95regulation of centrosome cycle (GO:0046605)3.02966834
96microtubule depolymerization (GO:0007019)3.01981707
97spliceosomal complex assembly (GO:0000245)3.01378452
98chromosome condensation (GO:0030261)3.00442559
99negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00049353
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.99865189
101ribosome assembly (GO:0042255)2.99786496
102pseudouridine synthesis (GO:0001522)2.98167547
103pteridine-containing compound biosynthetic process (GO:0042559)2.97947389
104nuclear envelope disassembly (GO:0051081)2.96816640
105membrane disassembly (GO:0030397)2.96816640
106deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.95799712
107anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.94280874
108mitotic nuclear envelope disassembly (GO:0007077)2.92787146
109regulation of chromosome segregation (GO:0051983)2.92377954
110viral mRNA export from host cell nucleus (GO:0046784)2.91771582
111rRNA metabolic process (GO:0016072)2.90924025
112regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.90882658
113negative regulation of DNA-templated transcription, elongation (GO:0032785)2.90830868
114negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.90830868
115DNA biosynthetic process (GO:0071897)2.90321894
116pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.90175914
117pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89708476
118protein localization to chromosome (GO:0034502)2.89105066
119purine nucleotide salvage (GO:0032261)2.88988956
120pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.88786764
121nuclear pore organization (GO:0006999)2.88384002
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87113297
123ribosomal large subunit biogenesis (GO:0042273)2.86278645
124chaperone-mediated protein transport (GO:0072321)2.86053693
125IMP metabolic process (GO:0046040)2.85352602
126folic acid metabolic process (GO:0046655)2.85045505
127negative regulation of chromosome segregation (GO:0051985)2.83757254
128postreplication repair (GO:0006301)2.83142409
129pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.82876173
130negative regulation of mRNA metabolic process (GO:1903312)2.82808193
131mitotic G2/M transition checkpoint (GO:0044818)2.82425076
132negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.81796708
133negative regulation of sister chromatid segregation (GO:0033046)2.81796708
134negative regulation of mitotic sister chromatid separation (GO:2000816)2.81796708
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.81796708
136regulation of nuclear cell cycle DNA replication (GO:0033262)2.81746089
137regulation of translational termination (GO:0006449)2.81068368
138somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80497397
139isotype switching (GO:0045190)2.80497397
140somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80497397
141protein deneddylation (GO:0000338)2.79224094
142negative regulation of ligase activity (GO:0051352)2.79076175
143negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79076175
144positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78067717
145mitotic spindle checkpoint (GO:0071174)2.77921809
146telomere organization (GO:0032200)2.77714116
147telomere maintenance (GO:0000723)2.77161156
148deoxyribonucleotide biosynthetic process (GO:0009263)2.77077156
149regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76661635
150mitotic cell cycle (GO:0000278)2.75019320
151DNA duplex unwinding (GO:0032508)2.71376145
152protoporphyrinogen IX metabolic process (GO:0046501)2.71061560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* E2F7_22180533_ChIP-Seq_HELA_Human9.15552002
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.70181678
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.42984551
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.08938656
5* MYC_18555785_ChIP-Seq_MESCs_Mouse3.81021828
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.66741646
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.64988183
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.30821261
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.21332333
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.09212475
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.93259661
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80811379
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78306211
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.73080729
15* AR_21909140_ChIP-Seq_LNCAP_Human2.57704350
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.54841606
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54298007
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.54112179
19* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52609043
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52012790
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49083714
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44181125
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42968103
24VDR_23849224_ChIP-Seq_CD4+_Human2.33144407
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27020671
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18138566
27XRN2_22483619_ChIP-Seq_HELA_Human2.10900245
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.09883210
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04814873
30MYC_22102868_ChIP-Seq_BL_Human1.97026907
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.93520152
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92251185
33ELK1_19687146_ChIP-ChIP_HELA_Human1.91666093
34* DCP1A_22483619_ChIP-Seq_HELA_Human1.90554445
35FOXP3_21729870_ChIP-Seq_TREG_Human1.87849714
36TTF2_22483619_ChIP-Seq_HELA_Human1.84752039
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.77821625
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69984104
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65531553
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62715927
41MYC_18940864_ChIP-ChIP_HL60_Human1.57406736
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57315169
43GABP_19822575_ChIP-Seq_HepG2_Human1.55888895
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.55798140
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.54663428
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53933674
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53899659
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53499516
49ZNF263_19887448_ChIP-Seq_K562_Human1.46319573
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45480302
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42680947
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41807298
53* VDR_21846776_ChIP-Seq_THP-1_Human1.41537380
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39165402
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37134173
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.35938591
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35895733
58* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33593780
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.28678168
60* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26634602
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25899896
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24886288
63TFEB_21752829_ChIP-Seq_HELA_Human1.23490659
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22132611
65EWS_26573619_Chip-Seq_HEK293_Human1.21686371
66IRF1_19129219_ChIP-ChIP_H3396_Human1.21566117
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.19906347
68* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18565781
69FUS_26573619_Chip-Seq_HEK293_Human1.17944793
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15729757
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14944233
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12430609
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12116139
74* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12048031
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11337312
76* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10379318
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09092165
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02108775
79KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00906634
80* KDM5A_27292631_Chip-Seq_BREAST_Human1.00832132
81PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98106471
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97584367
83TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96873807
84POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94875256
85SPI1_23547873_ChIP-Seq_NB4_Human0.93962429
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.93470868
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91302409
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.90016684
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89467298
90* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88142927
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86800293
92GATA1_26923725_Chip-Seq_HPCs_Mouse0.86416964
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.86043438
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85877238
95TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.84725927
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82866338
97* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82229978
98IGF1R_20145208_ChIP-Seq_DFB_Human0.82191706
99* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82124672
100NCOR1_26117541_ChIP-Seq_K562_Human0.81794448
101SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81337881
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.81322186
103ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81018210
104TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80851343
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80846235
106CIITA_25753668_ChIP-Seq_RAJI_Human0.80809975
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.80405531
108STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79505928
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79362210
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79062160
111* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78972325
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.75443078
113RBPJ_22232070_ChIP-Seq_NCS_Mouse0.73558651
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72392304
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.72031365
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.69785289
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.67444918
118PCGF2_27294783_Chip-Seq_ESCs_Mouse0.67380257
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67366894
120* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.66689877
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.66681183
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66677104
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.65972619
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.65241099
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.64833042
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.64833042
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.64833042
128POU3F2_20337985_ChIP-ChIP_501MEL_Human0.64430430
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.64336659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.90920518
2MP0003693_abnormal_embryo_hatching4.75278105
3MP0008057_abnormal_DNA_replication4.58879771
4MP0003111_abnormal_nucleus_morphology3.89851228
5MP0008877_abnormal_DNA_methylation3.83755460
6MP0004957_abnormal_blastocyst_morpholog3.82111313
7MP0003718_maternal_effect3.74774835
8MP0001529_abnormal_vocalization3.65308399
9MP0003077_abnormal_cell_cycle3.60478627
10MP0008932_abnormal_embryonic_tissue3.05352079
11MP0008058_abnormal_DNA_repair3.02252777
12MP0001905_abnormal_dopamine_level2.78014995
13MP0003806_abnormal_nucleotide_metabolis2.47673858
14MP0003136_yellow_coat_color2.47567992
15MP0002877_abnormal_melanocyte_morpholog2.44286389
16MP0003123_paternal_imprinting2.27307304
17MP0002102_abnormal_ear_morphology2.22200492
18MP0002210_abnormal_sex_determination2.13334097
19MP0008007_abnormal_cellular_replicative2.01447937
20MP0001929_abnormal_gametogenesis1.99952430
21MP0006292_abnormal_olfactory_placode1.98941467
22MP0003121_genomic_imprinting1.95953451
23MP0000653_abnormal_sex_gland1.80487780
24MP0006035_abnormal_mitochondrial_morpho1.74865519
25MP0003786_premature_aging1.73149220
26MP0001145_abnormal_male_reproductive1.68976837
27MP0000350_abnormal_cell_proliferation1.65401400
28MP0001119_abnormal_female_reproductive1.59488469
29MP0010352_gastrointestinal_tract_polyps1.59222648
30MP0009333_abnormal_splenocyte_physiolog1.58401857
31MP0003880_abnormal_central_pattern1.56464873
32MP0006036_abnormal_mitochondrial_physio1.54132892
33MP0001986_abnormal_taste_sensitivity1.52018202
34MP0005501_abnormal_skin_physiology1.49721136
35MP0000358_abnormal_cell_content/1.49637094
36MP0001730_embryonic_growth_arrest1.49344647
37MP0004808_abnormal_hematopoietic_stem1.47571585
38MP0004185_abnormal_adipocyte_glucose1.46833863
39MP0009379_abnormal_foot_pigmentation1.46029707
40MP0002396_abnormal_hematopoietic_system1.43069513
41MP0003763_abnormal_thymus_physiology1.38586764
42MP0003315_abnormal_perineum_morphology1.36893329
43MP0008260_abnormal_autophagy1.35966265
44MP0005395_other_phenotype1.32521462
45MP0003699_abnormal_female_reproductive1.32083298
46MP0003937_abnormal_limbs/digits/tail_de1.29428444
47MP0005409_darkened_coat_color1.27695941
48MP0005408_hypopigmentation1.25134556
49MP0001919_abnormal_reproductive_system1.23949933
50MP0001188_hyperpigmentation1.16221312
51MP0005389_reproductive_system_phenotype1.15732609
52MP0001697_abnormal_embryo_size1.14962775
53MP0002019_abnormal_tumor_incidence1.11293695
54MP0002161_abnormal_fertility/fecundity1.08822667
55MP0002085_abnormal_embryonic_tissue1.08123411
56MP0003698_abnormal_male_reproductive1.07314596
57MP0010234_abnormal_vibrissa_follicle1.07221844
58MP0005464_abnormal_platelet_physiology1.06356733
59MP0000313_abnormal_cell_death1.06006068
60MP0001881_abnormal_mammary_gland1.05701677
61MP0001545_abnormal_hematopoietic_system1.05512617
62MP0005397_hematopoietic_system_phenotyp1.05512617
63MP0005621_abnormal_cell_physiology1.04315397
64MP0003656_abnormal_erythrocyte_physiolo1.03863740
65MP0001727_abnormal_embryo_implantation1.02702831
66MP0002163_abnormal_gland_morphology1.01863594
67MP0000703_abnormal_thymus_morphology0.95390573
68MP0006072_abnormal_retinal_apoptosis0.95093952
69MP0001853_heart_inflammation0.94470214
70MP0000490_abnormal_crypts_of0.94436513
71MP0000566_synostosis0.92804297
72MP0002006_tumorigenesis0.91281211
73MP0005423_abnormal_somatic_nervous0.90951460
74MP0005076_abnormal_cell_differentiation0.90441368
75MP0004233_abnormal_muscle_weight0.90197052
76MP0008995_early_reproductive_senescence0.88917072
77MP0002796_impaired_skin_barrier0.88678265
78MP0005379_endocrine/exocrine_gland_phen0.87608773
79MP0010307_abnormal_tumor_latency0.86976174
80MP0009278_abnormal_bone_marrow0.86836523
81MP0000678_abnormal_parathyroid_gland0.86299719
82MP0005380_embryogenesis_phenotype0.85913784
83MP0001672_abnormal_embryogenesis/_devel0.85913784
84MP0002160_abnormal_reproductive_system0.85072170
85MP0003705_abnormal_hypodermis_morpholog0.84588436
86MP0006276_abnormal_autonomic_nervous0.84583390
87MP0000689_abnormal_spleen_morphology0.84077597
88MP0005171_absent_coat_pigmentation0.83680433
89MP0002080_prenatal_lethality0.83008617
90MP0003221_abnormal_cardiomyocyte_apopto0.81615086
91MP0001346_abnormal_lacrimal_gland0.81416101
92MP0000015_abnormal_ear_pigmentation0.80841247
93MP0002132_abnormal_respiratory_system0.80221976
94MP0002398_abnormal_bone_marrow0.79955234
95MP0005451_abnormal_body_composition0.79193168
96MP0001485_abnormal_pinna_reflex0.78844464
97MP0000858_altered_metastatic_potential0.78622855
98MP0004381_abnormal_hair_follicle0.77426772
99MP0004147_increased_porphyrin_level0.76974984
100MP0001661_extended_life_span0.76832836
101MP0003787_abnormal_imprinting0.75916465
102MP0002009_preneoplasia0.74389832
103MP0000681_abnormal_thyroid_gland0.74148634
104MP0002938_white_spotting0.74076763
105MP0004142_abnormal_muscle_tone0.74066395
106MP0001764_abnormal_homeostasis0.73748582
107MP0005310_abnormal_salivary_gland0.73040844
108MP0002722_abnormal_immune_system0.72759773
109MP0002166_altered_tumor_susceptibility0.71732112
110MP0000627_abnormal_mammary_gland0.71371700
111MP0000372_irregular_coat_pigmentation0.71281301
112MP0002084_abnormal_developmental_patter0.70954697
113MP0004145_abnormal_muscle_electrophysio0.69397121
114MP0002970_abnormal_white_adipose0.68356369
115MP0009697_abnormal_copulation0.68286613
116MP0002234_abnormal_pharynx_morphology0.67620362
117MP0002095_abnormal_skin_pigmentation0.67254250
118MP0003938_abnormal_ear_development0.66536427
119MP0002254_reproductive_system_inflammat0.65366243
120MP0002420_abnormal_adaptive_immunity0.65176059
121MP0005266_abnormal_metabolism0.63508177
122MP0001819_abnormal_immune_cell0.61805284
123MP0000462_abnormal_digestive_system0.61401417
124MP0009672_abnormal_birth_weight0.61337492
125MP0005623_abnormal_meninges_morphology0.61034311
126MP0001216_abnormal_epidermal_layer0.59902146
127MP0000631_abnormal_neuroendocrine_gland0.59404432
128MP0001915_intracranial_hemorrhage0.59105535
129MP0003950_abnormal_plasma_membrane0.58596282
130MP0000639_abnormal_adrenal_gland0.58220975
131MP0002429_abnormal_blood_cell0.58090255
132MP0002177_abnormal_outer_ear0.57750235
133MP0008872_abnormal_physiological_respon0.57714443
134MP0003984_embryonic_growth_retardation0.54443271
135MP0003755_abnormal_palate_morphology0.54093062
136MP0008789_abnormal_olfactory_epithelium0.53702685
137MP0003861_abnormal_nervous_system0.53543334
138MP0001800_abnormal_humoral_immune0.51427445
139MP0002086_abnormal_extraembryonic_tissu0.50676475
140MP0001186_pigmentation_phenotype0.49551531
141MP0000716_abnormal_immune_system0.49347497
142MP0002088_abnormal_embryonic_growth/wei0.49156159
143MP0003186_abnormal_redox_activity0.49018342
144MP0005384_cellular_phenotype0.48811081

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.60372808
2Chromsome breakage (HP:0040012)5.24583673
3Duplicated collecting system (HP:0000081)5.03831173
4Breast hypoplasia (HP:0003187)5.03677124
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.82790699
6Abnormality of the renal collecting system (HP:0004742)4.60098098
7Microvesicular hepatic steatosis (HP:0001414)4.58899666
8Reticulocytopenia (HP:0001896)3.97096688
9Abnormality of chromosome stability (HP:0003220)3.46099712
10Progressive muscle weakness (HP:0003323)3.37461439
11Patellar aplasia (HP:0006443)3.34220049
12Abnormality of cells of the erythroid lineage (HP:0012130)3.33386704
13Carpal bone hypoplasia (HP:0001498)3.28275907
14Ragged-red muscle fibers (HP:0003200)3.26073080
15Acute lymphatic leukemia (HP:0006721)3.13898584
16Abnormal number of erythroid precursors (HP:0012131)3.09672193
17Aplasia/Hypoplasia of the patella (HP:0006498)3.08837997
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.08454892
19Abnormality of the labia minora (HP:0012880)2.98227318
20Absent radius (HP:0003974)2.95120892
21Abnormality of the preputium (HP:0100587)2.93003994
22Meckel diverticulum (HP:0002245)2.92807464
23Multiple enchondromatosis (HP:0005701)2.87489781
24Absent forearm bone (HP:0003953)2.84085595
25Aplasia involving forearm bones (HP:0009822)2.84085595
26Cortical dysplasia (HP:0002539)2.79224490
27Abnormality of the ileum (HP:0001549)2.77283819
28Supernumerary spleens (HP:0009799)2.75158628
29Abnormality of glycolysis (HP:0004366)2.74865015
30Increased hepatocellular lipid droplets (HP:0006565)2.74018404
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.67473200
32Increased serum pyruvate (HP:0003542)2.64633894
33Poikiloderma (HP:0001029)2.61236643
34Cerebral hypomyelination (HP:0006808)2.59197161
35Macrocytic anemia (HP:0001972)2.59032890
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58353467
37Abnormality of the anterior horn cell (HP:0006802)2.57291553
38Degeneration of anterior horn cells (HP:0002398)2.57291553
39Secondary amenorrhea (HP:0000869)2.55554835
40Cholecystitis (HP:0001082)2.54064351
41Abnormal gallbladder physiology (HP:0012438)2.54064351
42Abnormality of the fetal cardiovascular system (HP:0010948)2.53661187
43Abnormal umbilical cord blood vessels (HP:0011403)2.53661187
44Single umbilical artery (HP:0001195)2.53661187
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.52290461
46Type I transferrin isoform profile (HP:0003642)2.50665058
47Clubbing of toes (HP:0100760)2.48702421
48Agnosia (HP:0010524)2.47307113
49Orthostatic hypotension (HP:0001278)2.46947811
50Pancytopenia (HP:0001876)2.44415321
51Small intestinal stenosis (HP:0012848)2.41636630
52Duodenal stenosis (HP:0100867)2.41636630
53Aplasia/Hypoplasia of the earlobes (HP:0009906)2.39707515
54Pallor (HP:0000980)2.38583278
55Ectopic kidney (HP:0000086)2.37405281
56Mitochondrial inheritance (HP:0001427)2.36427665
57Abnormal lung lobation (HP:0002101)2.35573959
58Increased nuchal translucency (HP:0010880)2.35205485
59Horseshoe kidney (HP:0000085)2.35019842
60Triphalangeal thumb (HP:0001199)2.32071700
61Squamous cell carcinoma (HP:0002860)2.31916593
62Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.29057804
63Decreased activity of mitochondrial respiratory chain (HP:0008972)2.29057804
64Entropion (HP:0000621)2.27861010
65Rough bone trabeculation (HP:0100670)2.27460231
66Absent thumb (HP:0009777)2.25643923
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25010278
68Abnormality of alanine metabolism (HP:0010916)2.25010278
69Hyperalaninemia (HP:0003348)2.25010278
703-Methylglutaconic aciduria (HP:0003535)2.23453586
71Aplasia/Hypoplasia involving the musculature (HP:0001460)2.23288142
72Premature ovarian failure (HP:0008209)2.22268442
73Proximal placement of thumb (HP:0009623)2.21139104
74Acute necrotizing encephalopathy (HP:0006965)2.20934195
75Colon cancer (HP:0003003)2.19760259
76Testicular atrophy (HP:0000029)2.19038243
77Selective tooth agenesis (HP:0001592)2.19030385
78Adrenal hypoplasia (HP:0000835)2.18659850
79Hypertensive crisis (HP:0100735)2.18456193
80Abnormality of the umbilical cord (HP:0010881)2.18099838
81Exertional dyspnea (HP:0002875)2.17383105
82Abnormal protein glycosylation (HP:0012346)2.15974281
83Abnormal glycosylation (HP:0012345)2.15974281
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15974281
85Abnormal protein N-linked glycosylation (HP:0012347)2.15974281
86Trismus (HP:0000211)2.15798625
87Rhabdomyosarcoma (HP:0002859)2.14731107
88Sloping forehead (HP:0000340)2.14262618
89Lipid accumulation in hepatocytes (HP:0006561)2.13922297
90Medulloblastoma (HP:0002885)2.13710990
91B lymphocytopenia (HP:0010976)2.13698298
92Abnormality of B cell number (HP:0010975)2.13698298
93Progressive external ophthalmoplegia (HP:0000590)2.11389433
94Insomnia (HP:0100785)2.10696212
95Short thumb (HP:0009778)2.09526651
96Microretrognathia (HP:0000308)2.09052632
97Increased CSF lactate (HP:0002490)2.08555120
98Petechiae (HP:0000967)2.08077780
99Nephroblastoma (Wilms tumor) (HP:0002667)2.07977883
100Impulsivity (HP:0100710)2.07707697
101Abnormality of the heme biosynthetic pathway (HP:0010472)2.06424674
102Hypoplasia of the capital femoral epiphysis (HP:0003090)2.06261626
103Ureteral duplication (HP:0000073)2.05472079
104Fatigue (HP:0012378)2.04208273
105Hepatocellular necrosis (HP:0001404)2.00607818
106Facial hemangioma (HP:0000329)2.00581733
107Deviation of the thumb (HP:0009603)1.99512475
108Myelodysplasia (HP:0002863)1.99279704
109Increased intramyocellular lipid droplets (HP:0012240)1.98958246
110Abnormality of the carotid arteries (HP:0005344)1.98762606
111Aplasia/Hypoplasia of the breasts (HP:0010311)1.98235776
112Agammaglobulinemia (HP:0004432)1.97748001
113Bone marrow hypocellularity (HP:0005528)1.97547076
114Recurrent viral infections (HP:0004429)1.96616440
115Abnormality of reticulocytes (HP:0004312)1.96603004
116Combined immunodeficiency (HP:0005387)1.96542272
117Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93517657
118Breast aplasia (HP:0100783)1.93384467
119Embryonal renal neoplasm (HP:0011794)1.92939305
120Oral leukoplakia (HP:0002745)1.92796892
121IgM deficiency (HP:0002850)1.91782152
122Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.91521015
123Renal Fanconi syndrome (HP:0001994)1.91292076
124Hypergonadotropic hypogonadism (HP:0000815)1.90088736
125Abnormality of cochlea (HP:0000375)1.90051988
126Type 2 muscle fiber atrophy (HP:0003554)1.88321403
127Aplasia/Hypoplasia of the thymus (HP:0010515)1.87953579
128Cutaneous melanoma (HP:0012056)1.87846637
129Hepatosplenomegaly (HP:0001433)1.87704041
130Abnormality of the duodenum (HP:0002246)1.87702951
131Aplastic anemia (HP:0001915)1.87571660
132Reduced antithrombin III activity (HP:0001976)1.86722447
133Short middle phalanx of the 5th finger (HP:0004220)1.85579774
134Respiratory difficulties (HP:0002880)1.84820980
135Lactic acidosis (HP:0003128)1.84231370
136Atrophy/Degeneration involving motor neurons (HP:0007373)1.82586938
137Exercise intolerance (HP:0003546)1.80802943
138Limb dystonia (HP:0002451)1.79730846
139Cleft eyelid (HP:0000625)1.79677035
140Abnormal mitochondria in muscle tissue (HP:0008316)1.78497292
141Acute encephalopathy (HP:0006846)1.78480527
142Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.77690323
143Abnormality of chromosome segregation (HP:0002916)1.77115839
144CNS hypomyelination (HP:0003429)1.76818145
145Hepatic necrosis (HP:0002605)1.76684539
146Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76251963
147Prostate neoplasm (HP:0100787)1.74338011
148Stenosis of the external auditory canal (HP:0000402)1.73880946
149Autoimmune hemolytic anemia (HP:0001890)1.73027581
150Fetal akinesia sequence (HP:0001989)1.72685032
151Muscle fiber atrophy (HP:0100295)1.72507524
152Severe combined immunodeficiency (HP:0004430)1.72435812
153Irregular epiphyses (HP:0010582)1.71462119
154Aplasia of the musculature (HP:0100854)1.71201038
155Pulmonary fibrosis (HP:0002206)1.70779471
156Postnatal microcephaly (HP:0005484)1.70704392
157Increased serum lactate (HP:0002151)1.70472952
158Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.69444002
159Abnormal trabecular bone morphology (HP:0100671)1.69046443
160Abnormality of DNA repair (HP:0003254)1.67847311
161Shoulder girdle muscle weakness (HP:0003547)1.66374830
162Reduced subcutaneous adipose tissue (HP:0003758)1.66010568
163Increased muscle lipid content (HP:0009058)1.65877024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.57003003
2MAP3K104.45928804
3BUB13.70233474
4PLK43.47763538
5WEE13.40985721
6SCYL23.32771186
7TTK2.94931390
8VRK22.77634181
9EIF2AK12.71095933
10ACVR1B2.61006689
11VRK12.18939603
12SRPK12.14957929
13NEK22.13517054
14NEK12.05295446
15BRAF2.03882977
16SMG11.99469486
17KDR1.99054924
18TAOK31.91304833
19PLK11.90747070
20MAP3K61.85768013
21TLK11.81095230
22MAPKAPK51.80899469
23BMPR21.77880222
24EIF2AK31.74486655
25TESK11.67143086
26STK161.67055761
27CHEK21.62255432
28PIM21.50651751
29MOS1.50106887
30BCKDK1.47087962
31STK101.41350874
32PNCK1.39283257
33IRAK31.35753430
34AURKB1.33529284
35CSNK1G31.33341602
36PLK31.31550903
37ATR1.31524240
38CCNB11.27439937
39BRSK21.26073762
40TAOK21.22729250
41MAP3K111.20752887
42MELK1.19967027
43TSSK61.16755083
44CDK121.16198127
45MKNK11.09508483
46ARAF1.09201724
47CDK71.08989646
48PRPF4B1.08575775
49PBK1.08238824
50TNIK1.07004109
51CSNK1G11.05821547
52EEF2K1.05194044
53MAP3K81.03300634
54CDK81.02997294
55AURKA1.01475727
56DAPK11.00831685
57FES1.00532869
58IRAK40.98480784
59MUSK0.97028221
60DYRK30.96261851
61MKNK20.94210559
62DYRK20.94115782
63NME20.91303153
64ATM0.86292392
65MST40.85496039
66EIF2AK20.83775943
67RPS6KB20.83619240
68CHEK10.82698552
69CLK10.82666882
70MAP2K30.82263438
71CSNK1G20.79280703
72RPS6KA50.78836609
73STK40.77671114
74ERN10.77664787
75MAPK130.77208077
76PLK20.77010315
77BRSK10.76897800
78CDK190.75588830
79MAPK110.74521547
80ABL20.70012534
81CASK0.69919163
82PAK40.68820619
83TESK20.66905908
84TAF10.65919293
85KSR20.64736759
86ADRBK20.64576450
87NUAK10.64041140
88* CSNK2A10.59475846
89TRIM280.59326053
90BLK0.58954262
91* CDK10.58312256
92CDK140.58156350
93CDK11A0.57043688
94* CDK20.55775968
95BMPR1B0.54824891
96LATS20.54591072
97NME10.54354510
98MAP3K140.53888248
99CDK60.53691710
100LIMK10.52519888
101* CSNK2A20.52312831
102LRRK20.51569565
103TYRO30.51120105
104MST1R0.50387617
105AKT20.50273588
106CDK150.49052532
107RAF10.47969234
108CDK180.47644607
109STK240.47567323
110PASK0.44989057
111ZAK0.44336229
112BMX0.43114654
113PRKCI0.42653525
114GRK60.42198532
115ROCK20.40694017
116CDK30.40560212
117MET0.38982705
118BRD40.38928312
119MAP3K120.38793955
120CDK40.38618760
121ADRBK10.38498532
122ERBB40.38320811
123CSNK1A1L0.37835732
124JAK30.37284979
125LYN0.35736522
126NLK0.35193241
127RPS6KA40.33873994
128MAP3K90.32129240
129PIM10.32121193
130MAP3K130.31214579
131MAP2K70.30963674
132PAK10.30315357
133MAP4K10.30256771
134FGR0.29903902
135YES10.27645340
136STK390.27187941
137MAPKAPK30.26571079
138CSNK1D0.25851614
139CDK90.24651537

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.95764788
2Mismatch repair_Homo sapiens_hsa034303.98684048
3Homologous recombination_Homo sapiens_hsa034403.68503121
4Ribosome_Homo sapiens_hsa030103.64015687
5RNA polymerase_Homo sapiens_hsa030203.29858082
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.03124971
7Cell cycle_Homo sapiens_hsa041102.91224800
8Non-homologous end-joining_Homo sapiens_hsa034502.90457955
9Fanconi anemia pathway_Homo sapiens_hsa034602.82777358
10Spliceosome_Homo sapiens_hsa030402.79760385
11Proteasome_Homo sapiens_hsa030502.79460784
12Nucleotide excision repair_Homo sapiens_hsa034202.79042016
13Basal transcription factors_Homo sapiens_hsa030222.78033480
14Base excision repair_Homo sapiens_hsa034102.72440500
15RNA transport_Homo sapiens_hsa030132.44848811
16Pyrimidine metabolism_Homo sapiens_hsa002402.44755434
17RNA degradation_Homo sapiens_hsa030182.27577089
18Oxidative phosphorylation_Homo sapiens_hsa001902.20070896
19Parkinsons disease_Homo sapiens_hsa050122.08431224
20Huntingtons disease_Homo sapiens_hsa050161.70680359
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.59468086
22Sulfur relay system_Homo sapiens_hsa041221.51214071
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.49889187
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48981886
25p53 signaling pathway_Homo sapiens_hsa041151.45718396
26Biosynthesis of amino acids_Homo sapiens_hsa012301.44331261
27One carbon pool by folate_Homo sapiens_hsa006701.44269031
28Purine metabolism_Homo sapiens_hsa002301.41077270
29Pentose phosphate pathway_Homo sapiens_hsa000301.35294323
30Alzheimers disease_Homo sapiens_hsa050101.28680242
31Protein export_Homo sapiens_hsa030601.27185376
32Oocyte meiosis_Homo sapiens_hsa041141.23626416
33mRNA surveillance pathway_Homo sapiens_hsa030151.20847053
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16335728
35Systemic lupus erythematosus_Homo sapiens_hsa053221.08782543
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07239261
37Carbon metabolism_Homo sapiens_hsa012001.07038129
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02314820
39Ether lipid metabolism_Homo sapiens_hsa005650.97517387
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93792836
41Fatty acid elongation_Homo sapiens_hsa000620.92878207
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85662971
43Folate biosynthesis_Homo sapiens_hsa007900.85057882
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85028358
45Epstein-Barr virus infection_Homo sapiens_hsa051690.84420412
46N-Glycan biosynthesis_Homo sapiens_hsa005100.80411336
47Vitamin B6 metabolism_Homo sapiens_hsa007500.80165748
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77930893
49Bladder cancer_Homo sapiens_hsa052190.77823127
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75798428
51Chronic myeloid leukemia_Homo sapiens_hsa052200.66858760
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64799609
53Alcoholism_Homo sapiens_hsa050340.64336956
54Pyruvate metabolism_Homo sapiens_hsa006200.63638493
55Linoleic acid metabolism_Homo sapiens_hsa005910.60990495
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59823129
57Arachidonic acid metabolism_Homo sapiens_hsa005900.59310067
58Herpes simplex infection_Homo sapiens_hsa051680.59098629
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57292673
60Selenocompound metabolism_Homo sapiens_hsa004500.55646948
61Ovarian steroidogenesis_Homo sapiens_hsa049130.55198105
62Non-small cell lung cancer_Homo sapiens_hsa052230.55087046
63Primary immunodeficiency_Homo sapiens_hsa053400.54511627
64Viral carcinogenesis_Homo sapiens_hsa052030.54397346
65Glutathione metabolism_Homo sapiens_hsa004800.54331513
66Fructose and mannose metabolism_Homo sapiens_hsa000510.51354645
67Sphingolipid metabolism_Homo sapiens_hsa006000.51262172
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50139080
69Galactose metabolism_Homo sapiens_hsa000520.49723199
70Steroid biosynthesis_Homo sapiens_hsa001000.49690287
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49145319
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.48958056
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48815962
74TGF-beta signaling pathway_Homo sapiens_hsa043500.48573296
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47585030
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.45528025
77MicroRNAs in cancer_Homo sapiens_hsa052060.44984889
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.43427937
79HTLV-I infection_Homo sapiens_hsa051660.42288954
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41915904
81Acute myeloid leukemia_Homo sapiens_hsa052210.39568896
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38921069
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38816885
84Hematopoietic cell lineage_Homo sapiens_hsa046400.38290057
85Serotonergic synapse_Homo sapiens_hsa047260.36910381
86Shigellosis_Homo sapiens_hsa051310.35049960
87Vibrio cholerae infection_Homo sapiens_hsa051100.34405632
88Phototransduction_Homo sapiens_hsa047440.34029985
89Metabolic pathways_Homo sapiens_hsa011000.33219734
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.31464790
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31230343
92B cell receptor signaling pathway_Homo sapiens_hsa046620.30371101
93Sulfur metabolism_Homo sapiens_hsa009200.29959616
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.28760560
95Graft-versus-host disease_Homo sapiens_hsa053320.25975458
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25149989
97Asthma_Homo sapiens_hsa053100.24486674
98Autoimmune thyroid disease_Homo sapiens_hsa053200.24062485
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23552848
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23186590
101Colorectal cancer_Homo sapiens_hsa052100.22239633
102Legionellosis_Homo sapiens_hsa051340.22049361
103Allograft rejection_Homo sapiens_hsa053300.21786762
104Other glycan degradation_Homo sapiens_hsa005110.21700851
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21661544
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21615630
107Dorso-ventral axis formation_Homo sapiens_hsa043200.21490324
108Salmonella infection_Homo sapiens_hsa051320.21253296
109Pancreatic cancer_Homo sapiens_hsa052120.20213833
110Cardiac muscle contraction_Homo sapiens_hsa042600.19664134
111Long-term depression_Homo sapiens_hsa047300.18877482
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18430148
113Influenza A_Homo sapiens_hsa051640.18379421
114Thyroid cancer_Homo sapiens_hsa052160.17937052
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.15216880
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14858916
117Rheumatoid arthritis_Homo sapiens_hsa053230.14680569
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.12755581
119Small cell lung cancer_Homo sapiens_hsa052220.12535119
120Chemokine signaling pathway_Homo sapiens_hsa040620.12404651
121Apoptosis_Homo sapiens_hsa042100.11978649
122Hedgehog signaling pathway_Homo sapiens_hsa043400.11356873
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.11290804
124Regulation of autophagy_Homo sapiens_hsa041400.10954932
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10089678
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10056330
127Antigen processing and presentation_Homo sapiens_hsa046120.09813951
128Collecting duct acid secretion_Homo sapiens_hsa049660.09804990
129Pathways in cancer_Homo sapiens_hsa052000.09730733
130Hepatitis B_Homo sapiens_hsa051610.09623721
131Measles_Homo sapiens_hsa051620.07955742
132Choline metabolism in cancer_Homo sapiens_hsa052310.07359261
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.06498431
134Renal cell carcinoma_Homo sapiens_hsa052110.06161671
135Viral myocarditis_Homo sapiens_hsa054160.03531783
136Prostate cancer_Homo sapiens_hsa052150.02823145

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