SLC10A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)9.41430913
2regulation of guanylate cyclase activity (GO:0031282)8.15861556
3lipoprotein transport (GO:0042953)7.79555397
4NADH metabolic process (GO:0006734)7.51886583
5epoxygenase P450 pathway (GO:0019373)7.18023859
6fat-soluble vitamin biosynthetic process (GO:0042362)7.09021929
7indole-containing compound catabolic process (GO:0042436)6.67288581
8indolalkylamine catabolic process (GO:0046218)6.67288581
9tryptophan catabolic process (GO:0006569)6.67288581
10positive regulation of guanylate cyclase activity (GO:0031284)6.40217700
11aromatic amino acid family catabolic process (GO:0009074)6.33818621
12tryptophan metabolic process (GO:0006568)6.25087225
13hormone catabolic process (GO:0042447)6.00212059
14L-phenylalanine catabolic process (GO:0006559)5.90474612
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.90474612
16regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.90023861
17endocrine process (GO:0050886)5.90023861
18regulation of systemic arterial blood pressure by hormone (GO:0001990)5.90023861
19kynurenine metabolic process (GO:0070189)5.87486288
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.71214304
21L-phenylalanine metabolic process (GO:0006558)5.71214304
22drug transmembrane transport (GO:0006855)5.39364680
23virion attachment to host cell (GO:0019062)5.33648480
24adhesion of symbiont to host cell (GO:0044650)5.33648480
25lysine metabolic process (GO:0006553)5.32094427
26lysine catabolic process (GO:0006554)5.32094427
27regulation of systemic arterial blood pressure (GO:0003073)5.30092232
28drug metabolic process (GO:0017144)5.25653606
29homocysteine metabolic process (GO:0050667)5.25300454
30cysteine metabolic process (GO:0006534)5.10401624
31glyoxylate metabolic process (GO:0046487)5.09988252
32regulation of bile acid biosynthetic process (GO:0070857)5.04044168
33regulation of cGMP biosynthetic process (GO:0030826)4.95589237
34peptide hormone processing (GO:0016486)4.94917530
35urate metabolic process (GO:0046415)4.89849548
36sulfur amino acid catabolic process (GO:0000098)4.89716716
37amine catabolic process (GO:0009310)4.85396892
38cellular biogenic amine catabolic process (GO:0042402)4.85396892
39diacylglycerol metabolic process (GO:0046339)4.84448677
40regulation of cellular extravasation (GO:0002691)4.81642850
41indolalkylamine metabolic process (GO:0006586)4.80624759
42* bile acid and bile salt transport (GO:0015721)4.80217886
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.77829770
44peptide catabolic process (GO:0043171)4.77482542
45receptor guanylyl cyclase signaling pathway (GO:0007168)4.75821777
46bile acid biosynthetic process (GO:0006699)4.61612164
47aromatic amino acid family metabolic process (GO:0009072)4.59882192
48drug transport (GO:0015893)4.56389142
49adhesion of symbiont to host (GO:0044406)4.52867285
50drug catabolic process (GO:0042737)4.52825013
51digestion (GO:0007586)4.49082665
52plasma lipoprotein particle assembly (GO:0034377)4.42627789
53renal system process involved in regulation of blood volume (GO:0001977)4.42316690
54amino-acid betaine metabolic process (GO:0006577)4.37437620
55urea metabolic process (GO:0019627)4.35795318
56urea cycle (GO:0000050)4.35795318
57* bile acid metabolic process (GO:0008206)4.34794700
58glycolipid catabolic process (GO:0019377)4.32945162
59cellular response to nitric oxide (GO:0071732)4.32877851
60glycosphingolipid catabolic process (GO:0046479)4.28544428
61cellular glucuronidation (GO:0052695)4.26153218
62vitamin A metabolic process (GO:0006776)4.16482601
63regulation of vitamin metabolic process (GO:0030656)4.15162080
64vitamin transmembrane transport (GO:0035461)4.14741247
65serine family amino acid catabolic process (GO:0009071)4.14659387
66regulation of cGMP metabolic process (GO:0030823)4.13751491
67cellular ketone body metabolic process (GO:0046950)4.13742922
68drinking behavior (GO:0042756)4.13505950
69benzene-containing compound metabolic process (GO:0042537)4.08578758
70triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.05602851
71vitamin transport (GO:0051180)4.02692927
72alkaloid metabolic process (GO:0009820)4.01549587
73protein-lipid complex assembly (GO:0065005)4.00833494
74alpha-amino acid catabolic process (GO:1901606)3.97585050
75nitrogen cycle metabolic process (GO:0071941)3.97291607
76exogenous drug catabolic process (GO:0042738)3.94848809
77glucuronate metabolic process (GO:0019585)3.94488225
78uronic acid metabolic process (GO:0006063)3.94488225
79fat-soluble vitamin metabolic process (GO:0006775)3.93509661
80alpha-linolenic acid metabolic process (GO:0036109)3.89978120
81complement activation, alternative pathway (GO:0006957)3.85761730
82glutamate metabolic process (GO:0006536)3.83205317
83antibacterial humoral response (GO:0019731)3.79097637
84high-density lipoprotein particle remodeling (GO:0034375)3.77327251
85regulation of protein activation cascade (GO:2000257)3.76584714
86tyrosine metabolic process (GO:0006570)3.76312778
87peptidyl-glutamic acid carboxylation (GO:0017187)3.74950913
88protein carboxylation (GO:0018214)3.74950913
89cellular amino acid catabolic process (GO:0009063)3.74912722
90response to nitric oxide (GO:0071731)3.73399052
91positive regulation of cGMP biosynthetic process (GO:0030828)3.70458419
92antimicrobial humoral response (GO:0019730)3.68175596
93short-chain fatty acid metabolic process (GO:0046459)3.67000961
94cellular response to reactive nitrogen species (GO:1902170)3.66002948
95cGMP biosynthetic process (GO:0006182)3.65614736
96phospholipid efflux (GO:0033700)3.64566053
97coenzyme catabolic process (GO:0009109)3.63455749
98cellular modified amino acid catabolic process (GO:0042219)3.61728992
99triglyceride homeostasis (GO:0070328)3.61245394
100acylglycerol homeostasis (GO:0055090)3.61245394
101intestinal absorption (GO:0050892)3.58947475
102indole-containing compound metabolic process (GO:0042430)3.58833247
103NAD biosynthetic process (GO:0009435)3.56728492
104carnitine metabolic process (GO:0009437)3.56319411
105phospholipid homeostasis (GO:0055091)3.55065700
106protein-lipid complex remodeling (GO:0034368)3.53821376
107macromolecular complex remodeling (GO:0034367)3.53821376
108plasma lipoprotein particle remodeling (GO:0034369)3.53821376
109ketone body metabolic process (GO:1902224)3.53095566
110intestinal cholesterol absorption (GO:0030299)3.53051069
111flavonoid metabolic process (GO:0009812)3.52737868
112regulation of complement activation (GO:0030449)3.50141355
113organic cation transport (GO:0015695)3.49629640
114cobalamin metabolic process (GO:0009235)3.49035964
115vitamin biosynthetic process (GO:0009110)3.48859920
116glutamine family amino acid biosynthetic process (GO:0009084)3.48266837
117maintenance of gastrointestinal epithelium (GO:0030277)3.47627676
118fructose metabolic process (GO:0006000)3.47352184
119ceramide catabolic process (GO:0046514)3.46864341
120positive regulation of glycoprotein biosynthetic process (GO:0010560)3.46421683
121positive regulation of triglyceride lipase activity (GO:0061365)3.45108508
122positive regulation of lipoprotein lipase activity (GO:0051006)3.45108508
123negative regulation of sterol transport (GO:0032372)3.43429325
124negative regulation of cholesterol transport (GO:0032375)3.43429325
125aspartate family amino acid catabolic process (GO:0009068)3.42362537
126regulation of cholesterol esterification (GO:0010872)3.41352333
1272-oxoglutarate metabolic process (GO:0006103)3.40510122
128reverse cholesterol transport (GO:0043691)3.39570172
129vitamin D metabolic process (GO:0042359)3.38816558
130low-density lipoprotein particle remodeling (GO:0034374)3.38211619
131regulation of triglyceride catabolic process (GO:0010896)3.38196602
132cGMP-mediated signaling (GO:0019934)3.36414809
133positive regulation of pseudopodium assembly (GO:0031274)3.35900720
134serine family amino acid metabolic process (GO:0009069)3.35458881
135phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.35142208
136regulation of fibrinolysis (GO:0051917)3.35141577
137dicarboxylic acid biosynthetic process (GO:0043650)3.34307981
138glycosylceramide metabolic process (GO:0006677)3.34126481
139carboxylic acid catabolic process (GO:0046395)3.33382782
140organic acid catabolic process (GO:0016054)3.33382782
141pyridine nucleotide biosynthetic process (GO:0019363)3.30020789
142nicotinamide nucleotide biosynthetic process (GO:0019359)3.30020789
143fatty acid beta-oxidation (GO:0006635)3.29902066
144fatty acid oxidation (GO:0019395)3.29594489
145acetyl-CoA metabolic process (GO:0006084)3.29271453
146negative regulation of fibrinolysis (GO:0051918)3.28314620
147positive regulation of lipid catabolic process (GO:0050996)3.27747075
148mRNA modification (GO:0016556)3.26669838
149sphingolipid catabolic process (GO:0030149)3.25366312
150lipid oxidation (GO:0034440)3.25032677
151arginine metabolic process (GO:0006525)3.22812452
152glycerol metabolic process (GO:0006071)3.21966913
153positive regulation of cGMP metabolic process (GO:0030825)3.21953651
154midgut development (GO:0007494)3.20414700
155lipoprotein metabolic process (GO:0042157)3.17353369
156L-ascorbic acid metabolic process (GO:0019852)3.15742332
157cholesterol efflux (GO:0033344)3.14924137
158digestive system process (GO:0022600)3.14287589
159renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.13314013
160phenol-containing compound catabolic process (GO:0019336)3.13252038
161sphingomyelin metabolic process (GO:0006684)3.12438928
162membrane lipid catabolic process (GO:0046466)3.12352399
163glomerulus development (GO:0032835)3.12336174
164sulfate transmembrane transport (GO:1902358)3.12177759
165regulation of cholesterol homeostasis (GO:2000188)3.11685295
166nucleoside diphosphate biosynthetic process (GO:0009133)3.11427338
167leukotriene metabolic process (GO:0006691)3.11403153
168very-low-density lipoprotein particle assembly (GO:0034379)3.11011198
169sexual reproduction (GO:0019953)3.09408557
170response to phenylpropanoid (GO:0080184)3.09080021
171positive regulation of glycoprotein metabolic process (GO:1903020)3.08649345
172transepithelial transport (GO:0070633)3.08488642
173actin filament depolymerization (GO:0030042)3.07081376
174response to nitrosative stress (GO:0051409)3.06853227
175imidazole-containing compound metabolic process (GO:0052803)3.05590162
176sterol homeostasis (GO:0055092)3.05356803
177angiotensin maturation (GO:0002003)12.4150152

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.98696416
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.31664539
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.12788123
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.40394430
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.34315417
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.43962715
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.31894886
8GATA1_22025678_ChIP-Seq_K562_Human3.01003686
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.94380958
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.91899272
11GATA6_25053715_ChIP-Seq_YYC3_Human2.50804523
12GBX2_23144817_ChIP-Seq_PC3_Human2.44658152
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.44253432
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.37436472
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.26023844
16CDX2_20551321_ChIP-Seq_CACO-2_Human1.95792747
17NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.95304538
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93289729
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88809567
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82745755
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79023018
22PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.76355525
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.65331497
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63408503
25FOXO3_23340844_ChIP-Seq_DLD1_Human1.61300668
26LXR_22292898_ChIP-Seq_THP-1_Human1.58442874
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58242089
28CLOCK_20551151_ChIP-Seq_293T_Human1.54812650
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.54215606
30* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52149310
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51671770
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51657093
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.46152925
34* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42984955
35* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.42824719
36* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41413000
37NFE2_27457419_Chip-Seq_LIVER_Mouse1.41005622
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.40331917
39FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40055677
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.37931395
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.35593646
42VDR_22108803_ChIP-Seq_LS180_Human1.34436291
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.32988751
44HTT_18923047_ChIP-ChIP_STHdh_Human1.32587013
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.32355705
46BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.31760707
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31151684
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.30318394
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29627497
50GATA2_19941826_ChIP-Seq_K562_Human1.26862490
51TAF15_26573619_Chip-Seq_HEK293_Human1.26400979
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24654191
53HNF4A_19822575_ChIP-Seq_HepG2_Human1.24383073
54FOXA1_25552417_ChIP-Seq_VCAP_Human1.24163205
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22378608
56GATA4_25053715_ChIP-Seq_YYC3_Human1.22347310
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18428477
58* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18212800
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18199557
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.18089175
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17899581
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16806742
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15107692
64SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15100512
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14572543
66BCOR_27268052_Chip-Seq_Bcells_Human1.13716730
67RACK7_27058665_Chip-Seq_MCF-7_Human1.13258099
68GATA1_19941826_ChIP-Seq_K562_Human1.13132764
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12572032
70SA1_27219007_Chip-Seq_Bcells_Human1.12048190
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11682661
72BCL6_27268052_Chip-Seq_Bcells_Human1.10886965
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09608883
74* P300_19829295_ChIP-Seq_ESCs_Human1.09419707
75P53_22387025_ChIP-Seq_ESCs_Mouse1.08300428
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08162716
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08162716
78RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07714408
79KLF5_25053715_ChIP-Seq_YYC3_Human1.07643214
80KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07449819
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07405706
82SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07259269
83* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06431576
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.06024535
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05440096
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05240891
87JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04881649
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.04152881
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.04073287
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03686762
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03085725
92OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02648002
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02501296
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.02174259
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01917228
96* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01516013
97EGR1_19032775_ChIP-ChIP_M12_Human1.01250097
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01232015
99SOX2_20726797_ChIP-Seq_SW620_Human1.00446168
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.00105630
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00037852
102ESR1_21235772_ChIP-Seq_MCF-7_Human0.99601778
103AR_21909140_ChIP-Seq_LNCAP_Human0.99541134
104OCT4_18555785_Chip-Seq_ESCs_Mouse0.99091793
105ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98339964
106NANOG_20526341_ChIP-Seq_ESCs_Human0.98111271
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97968469
108P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97621179
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95913764
110ESR1_20079471_ChIP-ChIP_T-47D_Human0.95768973
111CDX2_22108803_ChIP-Seq_LS180_Human0.95585700
112GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95397271
113STAT1_17558387_ChIP-Seq_HELA_Human0.94902284
114CTCF_27219007_Chip-Seq_Bcells_Human0.94542257
115TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94319884
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93957737
117PU1_27457419_Chip-Seq_LIVER_Mouse0.93779971
118RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93735818
119P300_18555785_Chip-Seq_ESCs_Mouse0.93606390
120CMYC_18555785_Chip-Seq_ESCs_Mouse0.92750389
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.91331508
122DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91041159
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.90272758
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90088748
125SMAD4_21799915_ChIP-Seq_A2780_Human0.90082577
126SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89784881
127SOX2_18555785_Chip-Seq_ESCs_Mouse0.89440300
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89404396
129KDM2B_26808549_Chip-Seq_REH_Human0.88443000
130BCAT_22108803_ChIP-Seq_LS180_Human0.88248391
131* RXR_22108803_ChIP-Seq_LS180_Human0.87178608
132SMAD1_18555785_Chip-Seq_ESCs_Mouse0.87094684
133NMYC_18555785_Chip-Seq_ESCs_Mouse0.87022550
134TAL1_26923725_Chip-Seq_HPCs_Mouse0.87008643
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86532284
136* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86217797
137ZFX_18555785_Chip-Seq_ESCs_Mouse0.86215863
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86214549
139CEBPB_22108803_ChIP-Seq_LS180_Human0.86152043
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85552137
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85530047
142VDR_24763502_ChIP-Seq_THP-1_Human0.85365333
143ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84910200
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.84855665
145* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84579583
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84488420
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83963376
148IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83763198
149AR_25329375_ChIP-Seq_VCAP_Human0.83757503
150NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83000116
151* VDR_24787735_ChIP-Seq_THP-1_Human0.82621999
152GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82491842
153CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.81811784
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81439084
155CTCF_18555785_Chip-Seq_ESCs_Mouse0.81052199
156STAT1_20625510_ChIP-Seq_HELA_Human0.80835511
157GATA2_21666600_ChIP-Seq_HMVEC_Human0.80674378
158ZNF263_19887448_ChIP-Seq_K562_Human0.79939030
159THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79465802
160RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79298527
161FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79250593
162CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78530735
163SOX2_22085726_ChIP-Seq_NPCs_Mouse0.77114414
164CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76675050
165NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76119061
166FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75650545
167SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75643549
168ESR2_21235772_ChIP-Seq_MCF-7_Human0.75643295
169TP63_23658742_ChIP-Seq_EP156T_Human0.75505761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.76544731
2MP0002139_abnormal_hepatobiliary_system6.94017913
3* MP0005085_abnormal_gallbladder_physiolo5.34790721
4* MP0005365_abnormal_bile_salt5.15186992
5MP0008875_abnormal_xenobiotic_pharmacok4.49819719
6MP0003252_abnormal_bile_duct4.05005523
7MP0009379_abnormal_foot_pigmentation3.86453878
8MP0004019_abnormal_vitamin_homeostasis3.17350423
9MP0005332_abnormal_amino_acid3.11583931
10MP0003195_calcinosis3.08532714
11MP0010329_abnormal_lipoprotein_level2.80294050
12MP0003806_abnormal_nucleotide_metabolis2.73425456
13MP0002138_abnormal_hepatobiliary_system2.72871537
14* MP0001666_abnormal_nutrient_absorption2.59732510
15MP0010234_abnormal_vibrissa_follicle2.55249697
16MP0003191_abnormal_cellular_cholesterol2.39031582
17MP0005409_darkened_coat_color2.30767620
18MP0002876_abnormal_thyroid_physiology2.18541572
19MP0009643_abnormal_urine_homeostasis1.98133339
20MP0000490_abnormal_crypts_of1.85293304
21MP0009697_abnormal_copulation1.84868710
22MP0004043_abnormal_pH_regulation1.83645973
23* MP0002118_abnormal_lipid_homeostasis1.61342908
24MP0005636_abnormal_mineral_homeostasis1.59115226
25MP0005319_abnormal_enzyme/_coenzyme1.54987874
26* MP0000609_abnormal_liver_physiology1.54727172
27MP0001764_abnormal_homeostasis1.53943480
28MP0003878_abnormal_ear_physiology1.53829780
29MP0005377_hearing/vestibular/ear_phenot1.53829780
30MP0009840_abnormal_foam_cell1.52607269
31MP0001188_hyperpigmentation1.52349810
32MP0000678_abnormal_parathyroid_gland1.50815767
33MP0005083_abnormal_biliary_tract1.50513203
34MP0010352_gastrointestinal_tract_polyps1.50089619
35MP0005084_abnormal_gallbladder_morpholo1.47179903
36MP0004264_abnormal_extraembryonic_tissu1.47043020
37* MP0003868_abnormal_feces_composition1.45532511
38MP0005451_abnormal_body_composition1.44314825
39MP0000538_abnormal_urinary_bladder1.40646389
40MP0005584_abnormal_enzyme/coenzyme_acti1.34664769
41MP0009764_decreased_sensitivity_to1.34279815
42MP0001765_abnormal_ion_homeostasis1.30713490
43MP0002822_catalepsy1.29826977
44MP0005670_abnormal_white_adipose1.29740057
45MP0004270_analgesia1.26954076
46MP0001501_abnormal_sleep_pattern1.26759383
47MP0001756_abnormal_urination1.23290703
48MP0004147_increased_porphyrin_level1.23121354
49MP0002136_abnormal_kidney_physiology1.20097580
50MP0000566_synostosis1.20018652
51MP0003186_abnormal_redox_activity1.05371117
52MP0002396_abnormal_hematopoietic_system0.98343785
53MP0002971_abnormal_brown_adipose0.98192876
54MP0004782_abnormal_surfactant_physiolog0.95995755
55MP0004858_abnormal_nervous_system0.93871279
56MP0005647_abnormal_sex_gland0.93739159
57MP0002277_abnormal_respiratory_mucosa0.90183252
58MP0008469_abnormal_protein_level0.88799184
59MP0003724_increased_susceptibility_to0.85091009
60MP0010155_abnormal_intestine_physiology0.83799476
61MP0009115_abnormal_fat_cell0.83784729
62* MP0009642_abnormal_blood_homeostasis0.83657047
63MP0002928_abnormal_bile_duct0.81259486
64MP0000537_abnormal_urethra_morphology0.74033119
65MP0000598_abnormal_liver_morphology0.72685245
66MP0001664_abnormal_digestion0.72003150
67MP0005408_hypopigmentation0.70791486
68MP0001663_abnormal_digestive_system0.70780835
69MP0002796_impaired_skin_barrier0.70148514
70MP0001873_stomach_inflammation0.68683819
71MP0005535_abnormal_body_temperature0.68571648
72MP0003183_abnormal_peptide_metabolism0.67489978
73MP0001485_abnormal_pinna_reflex0.67419250
74MP0005666_abnormal_adipose_tissue0.66912130
75MP0005174_abnormal_tail_pigmentation0.65770061
76MP0009763_increased_sensitivity_to0.65271137
77MP0005220_abnormal_exocrine_pancreas0.65199884
78MP0001661_extended_life_span0.63352058
79MP0000249_abnormal_blood_vessel0.60726642
80MP0008872_abnormal_physiological_respon0.60484930
81MP0009765_abnormal_xenobiotic_induced0.60003244
82MP0000230_abnormal_systemic_arterial0.59775092
83MP0000465_gastrointestinal_hemorrhage0.59703905
84MP0006138_congestive_heart_failure0.59261799
85MP0005381_digestive/alimentary_phenotyp0.58561718
86MP0002078_abnormal_glucose_homeostasis0.58490558
87MP0003866_abnormal_defecation0.58450768
88MP0005166_decreased_susceptibility_to0.58064407
89MP0002132_abnormal_respiratory_system0.57758721
90MP0005501_abnormal_skin_physiology0.57207071
91MP0001845_abnormal_inflammatory_respons0.56946308
92MP0000015_abnormal_ear_pigmentation0.56845898
93MP0005334_abnormal_fat_pad0.56767510
94MP0002166_altered_tumor_susceptibility0.55339876
95MP0005464_abnormal_platelet_physiology0.54482864
96MP0008260_abnormal_autophagy0.53923229
97MP0005448_abnormal_energy_balance0.51658174
98MP0001835_abnormal_antigen_presentation0.51469009
99MP0002254_reproductive_system_inflammat0.50932051
100MP0005025_abnormal_response_to0.50304998
101MP0005167_abnormal_blood-brain_barrier0.50218149
102MP0002168_other_aberrant_phenotype0.50072171
103MP0005646_abnormal_pituitary_gland0.49580132
104MP0005395_other_phenotype0.48952866
105MP0004381_abnormal_hair_follicle0.48857972
106MP0000604_amyloidosis0.48638650
107MP0009333_abnormal_splenocyte_physiolog0.47701989
108MP0003953_abnormal_hormone_level0.47606625
109MP0002896_abnormal_bone_mineralization0.46720614
110MP0004947_skin_inflammation0.46559055
111MP0006082_CNS_inflammation0.46554241
112MP0005376_homeostasis/metabolism_phenot0.46511096
113MP0005248_abnormal_Harderian_gland0.46444569
114MP0003303_peritoneal_inflammation0.45818134
115MP0009384_cardiac_valve_regurgitation0.45639157
116MP0010386_abnormal_urinary_bladder0.45527163
117MP0003300_gastrointestinal_ulcer0.44578881
118MP0001881_abnormal_mammary_gland0.44352619
119MP0000462_abnormal_digestive_system0.43295027
120MP0009785_altered_susceptibility_to0.42861343
121MP0002098_abnormal_vibrissa_morphology0.42110323
122MP0002135_abnormal_kidney_morphology0.41243370
123MP0000579_abnormal_nail_morphology0.40870627
124MP0004484_altered_response_of0.40777610
125MP0003011_delayed_dark_adaptation0.40252136
126MP0000516_abnormal_urinary_system0.38801182
127MP0003638_abnormal_response/metabolism_0.37866257
128MP0003656_abnormal_erythrocyte_physiolo0.36915274
129MP0000477_abnormal_intestine_morphology0.36799733
130MP0003436_decreased_susceptibility_to0.35955817
131MP0003690_abnormal_glial_cell0.34975102
132MP0005058_abnormal_lysosome_morphology0.34322609
133MP0006036_abnormal_mitochondrial_physio0.33812784
134MP0002419_abnormal_innate_immunity0.32715640
135MP0003718_maternal_effect0.32351936
136MP0003879_abnormal_hair_cell0.29913386

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)5.95747000
2Intrahepatic cholestasis (HP:0001406)5.75621372
3Abnormality of vitamin B metabolism (HP:0004340)5.57652206
4Widely patent fontanelles and sutures (HP:0004492)5.19597335
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.09914783
6Conjugated hyperbilirubinemia (HP:0002908)4.99425455
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.98534507
8Prolonged partial thromboplastin time (HP:0003645)4.68166624
9Abnormality of aspartate family amino acid metabolism (HP:0010899)4.42145729
10Hyperglycinuria (HP:0003108)4.40667401
11Hyperactive renin-angiotensin system (HP:0000841)4.23729241
12Deep venous thrombosis (HP:0002625)4.16169649
13Xanthomatosis (HP:0000991)4.14607298
14Pigmentary retinal degeneration (HP:0001146)4.13045947
15Abnormality of sulfur amino acid metabolism (HP:0004339)4.13025314
16Hypobetalipoproteinemia (HP:0003563)4.10485282
17Joint hemorrhage (HP:0005261)4.03021648
18Nausea (HP:0002018)3.94820064
19Metabolic alkalosis (HP:0200114)3.93667909
20Thin bony cortex (HP:0002753)3.87294505
21Wide cranial sutures (HP:0010537)3.84396628
22Abnormality of glycine metabolism (HP:0010895)3.82667717
23Abnormality of serine family amino acid metabolism (HP:0010894)3.82667717
24Hyperammonemia (HP:0001987)3.72133107
25Complement deficiency (HP:0004431)3.67016938
26Ketosis (HP:0001946)3.63544683
27Abnormality of purine metabolism (HP:0004352)3.59632238
28Abnormality of proline metabolism (HP:0010907)3.58731677
29Hydroxyprolinuria (HP:0003080)3.58731677
30Gout (HP:0001997)3.51840278
31* Chronic diarrhea (HP:0002028)3.48644776
32Megaloblastic anemia (HP:0001889)3.45457467
33Hyperglycinemia (HP:0002154)3.44986658
34Abnormality of nucleobase metabolism (HP:0010932)3.44927685
35Alkalosis (HP:0001948)3.43593618
36Facial shape deformation (HP:0011334)3.42216372
37Potter facies (HP:0002009)3.42216372
38Proximal tubulopathy (HP:0000114)3.42102902
39Abnormality of fatty-acid metabolism (HP:0004359)3.36063012
40Decreased circulating renin level (HP:0003351)3.32802187
41Ketoacidosis (HP:0001993)3.25903872
42Epidermoid cyst (HP:0200040)3.25669633
43* Fat malabsorption (HP:0002630)3.24900347
44Abnormality of chloride homeostasis (HP:0011422)3.20974888
45Hyperlipoproteinemia (HP:0010980)3.18688092
46Hypomagnesemia (HP:0002917)3.16213898
47Vascular calcification (HP:0004934)3.15688152
48Abnormality of pyrimidine metabolism (HP:0004353)3.15518578
49Posterior subcapsular cataract (HP:0007787)3.10759159
50Abdominal distention (HP:0003270)3.06988433
51Tetany (HP:0001281)3.04828435
52Hypolipoproteinemia (HP:0010981)3.04478112
53Congenital sensorineural hearing impairment (HP:0008527)3.03818569
54Hypoglycemic coma (HP:0001325)3.02402792
55Hyperuricemia (HP:0002149)3.01680922
56Increased purine levels (HP:0004368)3.01680922
57Abnormality of methionine metabolism (HP:0010901)2.98884004
58Enlarged epiphyses (HP:0010580)2.95640786
59Metabolic acidosis (HP:0001942)2.95492930
60Increased circulating renin level (HP:0000848)2.85290118
61Abnormal urine phosphate concentration (HP:0012599)2.79096251
62Abnormality of the common coagulation pathway (HP:0010990)2.78172284
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.74612179
64Hyperparathyroidism (HP:0000843)2.74042042
65Delayed epiphyseal ossification (HP:0002663)2.73912572
66Cardiovascular calcification (HP:0011915)2.73247018
67Delayed CNS myelination (HP:0002188)2.71102144
68Hyperbilirubinemia (HP:0002904)2.68687501
69Abnormality of magnesium homeostasis (HP:0004921)2.67100565
70Dicarboxylic aciduria (HP:0003215)2.66925972
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66925972
72Enlarged kidneys (HP:0000105)2.65292335
73Renal cortical cysts (HP:0000803)2.63047701
74Hypoalphalipoproteinemia (HP:0003233)2.60819772
75Hyperaldosteronism (HP:0000859)2.60626639
76Generalized aminoaciduria (HP:0002909)2.60600455
77Abnormality of renin-angiotensin system (HP:0000847)2.59756696
78Malnutrition (HP:0004395)2.59610875
79Hypoglycemic seizures (HP:0002173)2.58616966
80Hypokalemic alkalosis (HP:0001949)2.58268296
81Abnormal urine output (HP:0012590)2.57124697
82Abnormality of complement system (HP:0005339)2.56140804
83Hyperphosphaturia (HP:0003109)2.55180464
84Systemic lupus erythematosus (HP:0002725)2.53815699
85Abnormality of the intrinsic pathway (HP:0010989)2.53786547
86Abnormality of the costochondral junction (HP:0000919)2.51523411
87Abnormality of renal excretion (HP:0011036)2.50490971
88Polyuria (HP:0000103)2.50345809
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.48742552
90Abnormality of serum amino acid levels (HP:0003112)2.48051560
91Abnormality of small intestinal villus morphology (HP:0011472)2.47651451
92Villous atrophy (HP:0011473)2.47651451
93Confusion (HP:0001289)2.47430806
94Hypotension (HP:0002615)2.47258397
95Alveolar cell carcinoma (HP:0006519)2.45726600
96Symptomatic seizures (HP:0011145)2.41821625
97Eczematoid dermatitis (HP:0000976)2.40747928
98Renal tubular acidosis (HP:0001947)2.36967019
99Focal segmental glomerulosclerosis (HP:0000097)2.36646339
100Rickets (HP:0002748)2.36453002
101Glycosuria (HP:0003076)2.35266481
102Abnormality of urine glucose concentration (HP:0011016)2.35266481
103Abnormal glucose tolerance (HP:0001952)2.32289361
104Hypercholesterolemia (HP:0003124)2.30293630
105Recurrent gram-negative bacterial infections (HP:0005420)2.28067139
106Lethargy (HP:0001254)2.26114798
107Subcapsular cataract (HP:0000523)2.25322538
108Hepatocellular carcinoma (HP:0001402)2.24988400
109Abnormality of vitamin metabolism (HP:0100508)2.22340417
110Poikilocytosis (HP:0004447)2.21294749
111Pancreatitis (HP:0001733)2.19888140
112Hemorrhage of the eye (HP:0011885)2.15061749
113Ileus (HP:0002595)2.12496176
114Myocardial infarction (HP:0001658)2.10520311
115Spontaneous abortion (HP:0005268)2.10246535
116Neoplasm of the tracheobronchial system (HP:0100552)2.09708857
117Hyperphosphatemia (HP:0002905)2.09680737
118Abnormal enzyme/coenzyme activity (HP:0012379)2.09671469
119Vomiting (HP:0002013)2.09357375
120Nephrolithiasis (HP:0000787)2.07476466
121Gingivitis (HP:0000230)2.05653251
122Hypophosphatemic rickets (HP:0004912)2.02972731
123Polydipsia (HP:0001959)2.02822072
124Abnormal drinking behavior (HP:0030082)2.02822072
125Sensorimotor neuropathy (HP:0007141)2.00748537
126Protuberant abdomen (HP:0001538)2.00474089
127Gastrointestinal dysmotility (HP:0002579)1.99076715
128Acanthocytosis (HP:0001927)1.98436356
129Hypophosphatemia (HP:0002148)1.98416852
130Cerebral palsy (HP:0100021)1.97247905
131Hyperventilation (HP:0002883)1.96597825
132Right ventricular cardiomyopathy (HP:0011663)1.96330708
133Abnormality of the vitamin B12 metabolism (HP:0004341)1.95090726
134Vacuolated lymphocytes (HP:0001922)1.94615761
135Mitral stenosis (HP:0001718)1.93894074
136Multiple lipomas (HP:0001012)1.90888011
137Irritability (HP:0000737)1.90067745
138Renal tubular dysfunction (HP:0000124)1.89564828
139White forelock (HP:0002211)1.87661723
140Growth hormone excess (HP:0000845)1.84316540
141Patchy hypopigmentation of hair (HP:0011365)1.81628219
142Hypocalcemia (HP:0002901)1.78122036
143Abnormality of alkaline phosphatase activity (HP:0004379)1.77889100
144Paresthesia (HP:0003401)1.76408703
145Segmental peripheral demyelination/remyelination (HP:0003481)1.74154203
146Glomerulosclerosis (HP:0000096)1.71786660
147Metaphyseal irregularity (HP:0003025)1.71653485
148Hypoalbuminemia (HP:0003073)1.69758916
149Abnormal albumin level (HP:0012116)1.69758916
150Dehydration (HP:0001944)1.61779001
151Peripheral demyelination (HP:0011096)1.60785068
152Macrocytic anemia (HP:0001972)1.59885889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B9.01004356
2FRK4.91392040
3WNK33.97502938
4MAP3K103.68318896
5INSRR3.65817961
6BCKDK2.75798326
7OXSR12.75695351
8MAP3K142.71121475
9SIK32.67081253
10EPHA22.55012600
11STK38L2.43923564
12CASK2.43426801
13MST1R2.18157770
14STK392.05515339
15SIK12.04478794
16AKT32.01780912
17TAOK31.99572011
18IRAK31.95378359
19PDK21.94606667
20SGK21.93319578
21WNK41.89013655
22FGFR41.86585337
23TESK21.85741679
24ERBB41.76637269
25MAP3K21.74834687
26ERN11.59294316
27SGK31.58060032
28SGK4941.54727862
29SGK2231.54727862
30MAPK111.54273554
31ZAK1.54162541
32MET1.44310498
33MYLK1.35920797
34LATS11.34233184
35MAP4K11.33538408
36TXK1.28923038
37PIK3CA1.26675022
38DDR21.26642435
39RIPK41.25919547
40TNIK1.23035868
41PIK3CG1.22429944
42PRKAA21.21899163
43EPHB11.18681611
44PRPF4B1.17691354
45GRK11.16641404
46MATK1.13941342
47MAP3K71.11111603
48NEK91.02983408
49STK241.01763001
50NUAK11.01222949
51PINK11.00822126
52MAP3K11.00778777
53MAP2K71.00426897
54MST40.95145622
55BMPR20.92214587
56PIM10.91234347
57PDPK10.87927047
58ADRBK20.87873594
59TIE10.85576405
60MAP2K40.84319827
61IRAK40.82594492
62DYRK1B0.82203470
63JAK10.80624958
64NLK0.79869170
65BMPR1B0.79851545
66PRKAA10.79711267
67TYK20.79560072
68IKBKE0.77656212
69PRKG20.76955054
70CDK80.76340414
71ERBB20.74306481
72TGFBR20.73713354
73GRK60.72981417
74MAP3K130.72142837
75TEC0.72078082
76YES10.70862641
77PDK10.70168990
78CDC42BPA0.70118299
79MAP3K110.69833779
80TESK10.67954705
81PTK60.67391648
82EIF2AK20.67183450
83TAOK10.66021472
84ITK0.64206483
85CHUK0.63817545
86MAPK70.63747267
87LMTK20.63564001
88CAMK2G0.60352309
89EPHB20.57920649
90PRKCZ0.54242024
91PRKCQ0.52696525
92IRAK20.52547667
93IRAK10.52015713
94EPHA30.51966958
95IKBKB0.51938111
96KSR20.51489306
97EPHA40.50581887
98CSF1R0.50366093
99MAPK150.49527287
100MAP3K120.47970928
101PRKCE0.47449115
102TBK10.47136428
103PRKACG0.46051093
104MAPK40.44915990
105PRKCD0.44779557
106TAOK20.44430716
107SRC0.44376041
108FYN0.44012297
109FGFR20.43581756
110STK30.43325332
111GSK3A0.42472447
112MAP2K60.42349259
113SGK10.41635495
114BTK0.41176581
115RET0.41018267
116PKN10.40771670
117PRKCA0.40299489
118CAMK2D0.40155519
119PTK20.39765173
120NEK60.38173037
121JAK20.37404598
122FER0.37002450
123SYK0.36616489
124PDGFRA0.36524907
125KIT0.36270500
126DAPK20.35840588
127RIPK10.35377577
128CDK190.35078113
129MAP2K20.33343747
130CSK0.33257667
131CDK60.32998335
132ABL20.32551004
133CAMK2B0.32534698
134IGF1R0.31423023
135MAP3K30.31211336
136FGFR30.29445827
137CAMK40.29428926
138CDK30.29205074
139MARK30.29204559
140PAK40.29116986
141MAPK120.28874047
142MELK0.28082894
143TRIB30.24225436
144LYN0.22301169
145PRKACA0.21577054
146MAP3K80.21514455
147BMX0.20594366
148RPS6KA20.20190605
149LCK0.20015818
150MAPKAPK20.17057355

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.52577961
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33850641
3Tryptophan metabolism_Homo sapiens_hsa003802.91157533
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.55900399
5Arginine biosynthesis_Homo sapiens_hsa002202.53679385
6Sulfur metabolism_Homo sapiens_hsa009202.47524709
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.45085898
8Butanoate metabolism_Homo sapiens_hsa006502.41386972
9Peroxisome_Homo sapiens_hsa041462.37250164
10Fatty acid degradation_Homo sapiens_hsa000712.36957883
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34404373
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32996408
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27983398
14Nitrogen metabolism_Homo sapiens_hsa009102.22950018
15Histidine metabolism_Homo sapiens_hsa003402.21935870
16Complement and coagulation cascades_Homo sapiens_hsa046102.11480094
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05956884
18beta-Alanine metabolism_Homo sapiens_hsa004102.02696113
19Propanoate metabolism_Homo sapiens_hsa006402.00651725
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.97893725
21Vitamin digestion and absorption_Homo sapiens_hsa049771.96106818
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.94041407
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93745403
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91730482
25PPAR signaling pathway_Homo sapiens_hsa033201.91223154
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.86042759
27* Bile secretion_Homo sapiens_hsa049761.74712019
28Fatty acid metabolism_Homo sapiens_hsa012121.65514746
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61740589
30Chemical carcinogenesis_Homo sapiens_hsa052041.60830490
31Starch and sucrose metabolism_Homo sapiens_hsa005001.55810785
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55154221
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.47440034
34Retinol metabolism_Homo sapiens_hsa008301.46528529
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45977789
36Phenylalanine metabolism_Homo sapiens_hsa003601.41985968
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.40438918
38Staphylococcus aureus infection_Homo sapiens_hsa051501.40225217
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.34474902
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30054767
41Pyruvate metabolism_Homo sapiens_hsa006201.29360835
42ABC transporters_Homo sapiens_hsa020101.27365029
43Caffeine metabolism_Homo sapiens_hsa002321.26737619
44Selenocompound metabolism_Homo sapiens_hsa004501.26342626
45Fat digestion and absorption_Homo sapiens_hsa049751.25795196
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23554929
47Tyrosine metabolism_Homo sapiens_hsa003501.16124500
48Arginine and proline metabolism_Homo sapiens_hsa003301.13350285
49Fatty acid elongation_Homo sapiens_hsa000621.11741620
50Folate biosynthesis_Homo sapiens_hsa007901.05796285
51Lysine degradation_Homo sapiens_hsa003101.02929445
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99656037
53Steroid biosynthesis_Homo sapiens_hsa001000.99468545
54Mineral absorption_Homo sapiens_hsa049780.97912426
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97279114
56Glutathione metabolism_Homo sapiens_hsa004800.96438509
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92293120
58Asthma_Homo sapiens_hsa053100.88479554
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.84902760
60Carbon metabolism_Homo sapiens_hsa012000.84481725
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83595043
62Glycerolipid metabolism_Homo sapiens_hsa005610.75964481
63Fructose and mannose metabolism_Homo sapiens_hsa000510.71068863
64Renin-angiotensin system_Homo sapiens_hsa046140.69606531
65Biosynthesis of amino acids_Homo sapiens_hsa012300.66665523
66Allograft rejection_Homo sapiens_hsa053300.62894412
67Pancreatic secretion_Homo sapiens_hsa049720.59226313
68Autoimmune thyroid disease_Homo sapiens_hsa053200.57597600
69Graft-versus-host disease_Homo sapiens_hsa053320.54802835
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53492838
71Sulfur relay system_Homo sapiens_hsa041220.52807627
72Metabolic pathways_Homo sapiens_hsa011000.52645970
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52338649
74Galactose metabolism_Homo sapiens_hsa000520.48424162
75Vitamin B6 metabolism_Homo sapiens_hsa007500.47481637
76Protein digestion and absorption_Homo sapiens_hsa049740.43380857
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43049385
78Renin secretion_Homo sapiens_hsa049240.41956515
79Type I diabetes mellitus_Homo sapiens_hsa049400.38193767
80Other glycan degradation_Homo sapiens_hsa005110.35745879
81Pentose phosphate pathway_Homo sapiens_hsa000300.35374744
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34382182
83Cocaine addiction_Homo sapiens_hsa050300.32524580
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.32067706
85Arachidonic acid metabolism_Homo sapiens_hsa005900.30140316
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29376069
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28214833
88Linoleic acid metabolism_Homo sapiens_hsa005910.22892991
89One carbon pool by folate_Homo sapiens_hsa006700.22559937
90Glucagon signaling pathway_Homo sapiens_hsa049220.20517566
91Antigen processing and presentation_Homo sapiens_hsa046120.20180137
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.19790748
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19576148
94Fatty acid biosynthesis_Homo sapiens_hsa000610.18292163
95Serotonergic synapse_Homo sapiens_hsa047260.15564895
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.15553502
97Leishmaniasis_Homo sapiens_hsa051400.14561086
98Amphetamine addiction_Homo sapiens_hsa050310.14512024
99Insulin secretion_Homo sapiens_hsa049110.14446879
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.14179463
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13058062
102Hepatitis C_Homo sapiens_hsa051600.10830599
103Collecting duct acid secretion_Homo sapiens_hsa049660.10467355
104Insulin resistance_Homo sapiens_hsa049310.09235625
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08173712
106Tight junction_Homo sapiens_hsa045300.07887629
107Sphingolipid metabolism_Homo sapiens_hsa006000.07518779
108Hematopoietic cell lineage_Homo sapiens_hsa046400.07496360
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.07276941
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.05674712
111Regulation of autophagy_Homo sapiens_hsa041400.05124908
112GnRH signaling pathway_Homo sapiens_hsa049120.04617688
113AMPK signaling pathway_Homo sapiens_hsa041520.04559017
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.02837261
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.02765136
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.02646511
117Viral myocarditis_Homo sapiens_hsa054160.02546279
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.02101618
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.01459392
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.01424809
121Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0344471
122Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0327344
123Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0212023
124Ether lipid metabolism_Homo sapiens_hsa00565-0.0131220
125Toxoplasmosis_Homo sapiens_hsa05145-0.0117343
126Gap junction_Homo sapiens_hsa04540-0.0079770
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0073144
128African trypanosomiasis_Homo sapiens_hsa05143-0.0025903

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