SLC10A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene maps to a GC-rich region of the X chromosome and was identified by its proximity to a CpG island. It is thought to be a housekeeping gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.62727419
2DNA deamination (GO:0045006)4.75992890
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.24199942
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.24199942
5negative regulation of erythrocyte differentiation (GO:0045647)4.18910836
6viral transcription (GO:0019083)4.00598237
7translational termination (GO:0006415)3.91959765
8maturation of SSU-rRNA (GO:0030490)3.91201448
9DNA strand elongation involved in DNA replication (GO:0006271)3.84009453
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.83867948
11telomere maintenance via semi-conservative replication (GO:0032201)3.82995849
12COPI coating of Golgi vesicle (GO:0048205)3.77275406
13Golgi transport vesicle coating (GO:0048200)3.77275406
14antigen processing and presentation of endogenous antigen (GO:0019883)3.72397816
15cotranslational protein targeting to membrane (GO:0006613)3.72112602
16protein targeting to ER (GO:0045047)3.71462944
17DNA strand elongation (GO:0022616)3.66425545
18translational elongation (GO:0006414)3.55540675
19protein localization to endoplasmic reticulum (GO:0070972)3.53387818
20response to peptidoglycan (GO:0032494)3.52729007
21establishment of protein localization to endoplasmic reticulum (GO:0072599)3.52257269
22protein localization to endosome (GO:0036010)3.52038030
23ribosomal small subunit biogenesis (GO:0042274)3.49475570
24positive regulation of Cdc42 GTPase activity (GO:0043089)3.45799665
25DNA replication initiation (GO:0006270)3.45708988
26telomere maintenance via recombination (GO:0000722)3.45184978
27pinocytosis (GO:0006907)3.42801262
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.37403338
29protein maturation by protein folding (GO:0022417)3.35698439
30barbed-end actin filament capping (GO:0051016)3.24432197
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24271338
32nucleobase biosynthetic process (GO:0046112)3.18488597
33IMP biosynthetic process (GO:0006188)3.18422177
34platelet aggregation (GO:0070527)3.17996143
35stress fiber assembly (GO:0043149)3.13085567
36translational initiation (GO:0006413)3.12979147
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10353904
38negative regulation of phagocytosis (GO:0050765)3.09752053
39ribosomal large subunit biogenesis (GO:0042273)3.09651589
40viral life cycle (GO:0019058)3.09651289
41mitotic recombination (GO:0006312)3.05552456
42purine nucleobase biosynthetic process (GO:0009113)3.03655945
43angiogenesis involved in wound healing (GO:0060055)3.02423320
44regulation of early endosome to late endosome transport (GO:2000641)3.02343142
45ribonucleoprotein complex biogenesis (GO:0022613)3.00091585
46IMP metabolic process (GO:0046040)3.00064759
47formation of translation preinitiation complex (GO:0001731)2.97077163
48fibril organization (GO:0097435)2.96976960
49DNA replication checkpoint (GO:0000076)2.96493697
50pentose-phosphate shunt (GO:0006098)2.95858727
51extracellular fibril organization (GO:0043206)2.95690369
52antigen processing and presentation via MHC class Ib (GO:0002475)2.91629990
53cellular protein complex disassembly (GO:0043624)2.90348024
54positive regulation of receptor recycling (GO:0001921)2.87657467
55DNA unwinding involved in DNA replication (GO:0006268)2.86487152
56pseudouridine synthesis (GO:0001522)2.86231102
57ribosome biogenesis (GO:0042254)2.85641108
58telomere maintenance via telomere lengthening (GO:0010833)2.85480304
59positive regulation by symbiont of host defense response (GO:0052509)2.85386565
60modulation by symbiont of host defense response (GO:0052031)2.85386565
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.85386565
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.85386565
63positive regulation by organism of defense response of other organism involved in symbiotic interact2.85386565
64modulation by symbiont of host immune response (GO:0052553)2.85386565
65immunoglobulin mediated immune response (GO:0016064)2.84248375
66response to interferon-beta (GO:0035456)2.83901890
67regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.82804968
68CENP-A containing nucleosome assembly (GO:0034080)2.82614293
69folic acid-containing compound biosynthetic process (GO:0009396)2.82341821
70regulation of mast cell degranulation (GO:0043304)2.82236887
71Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81634147
72nucleotide-excision repair, DNA gap filling (GO:0006297)2.79187612
73negative regulation of homotypic cell-cell adhesion (GO:0034111)2.77284276
74signal peptide processing (GO:0006465)2.77036151
75skin morphogenesis (GO:0043589)2.76283278
76regulation of leukocyte degranulation (GO:0043300)2.75741063
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.72548862
78positive regulation of gamma-delta T cell activation (GO:0046645)2.72422001
79regulation of platelet aggregation (GO:0090330)2.72105268
80chaperone mediated protein folding requiring cofactor (GO:0051085)2.72098661
81modulation by symbiont of host cellular process (GO:0044068)2.71755863
82positive regulation of B cell differentiation (GO:0045579)2.71043680
83positive regulation of macrophage differentiation (GO:0045651)2.66765450
84hyaluronan catabolic process (GO:0030214)2.66726590
85lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66396172
86negative regulation of protein localization to plasma membrane (GO:1903077)2.66284625
87glucose catabolic process (GO:0006007)2.63988978
88modulation by virus of host process (GO:0019054)2.63060204
89deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61026398
90chromatin remodeling at centromere (GO:0031055)2.60977803
91proteasome assembly (GO:0043248)2.59709727
92rRNA processing (GO:0006364)2.59524398
93cell-substrate junction assembly (GO:0007044)2.57379692
94positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56002340
95negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.55369083
96negative regulation of stress fiber assembly (GO:0051497)2.54863391
97nuclear-transcribed mRNA catabolic process (GO:0000956)2.53494778
98negative regulation of cell killing (GO:0031342)2.53384137
99negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.53384137
100translation (GO:0006412)2.52263562
101regulation of myeloid leukocyte mediated immunity (GO:0002886)2.51459254
102B cell mediated immunity (GO:0019724)2.51247517
103regulation of superoxide anion generation (GO:0032928)2.51132120
104protein complex disassembly (GO:0043241)2.50776445
105mannose metabolic process (GO:0006013)2.50482936
106granulocyte activation (GO:0036230)2.50230452
107rRNA metabolic process (GO:0016072)2.49480623
108regulation of integrin activation (GO:0033623)2.48227356
109regulation of mast cell activation involved in immune response (GO:0033006)2.47815771
110DNA replication-independent nucleosome organization (GO:0034724)2.47243341
111DNA replication-independent nucleosome assembly (GO:0006336)2.47243341
112cellular response to zinc ion (GO:0071294)2.46964015
113protein targeting to membrane (GO:0006612)2.45724395
114positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.45363774
115neutrophil activation (GO:0042119)2.45305728
116adenosine receptor signaling pathway (GO:0001973)2.44986969
117mRNA catabolic process (GO:0006402)2.44625624
118membrane raft organization (GO:0031579)2.44593480
119response to interferon-alpha (GO:0035455)2.43937271
120regulation of metalloenzyme activity (GO:0048552)2.43781733
121response to laminar fluid shear stress (GO:0034616)2.43619729
122NADPH regeneration (GO:0006740)2.42441189
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.39796001
124homotypic cell-cell adhesion (GO:0034109)2.39334838
125regulation of extracellular matrix disassembly (GO:0010715)2.39066891
126mitotic nuclear envelope disassembly (GO:0007077)2.38625861
127transcription-coupled nucleotide-excision repair (GO:0006283)2.38391556
128antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.37610565
129cellular response to thyroid hormone stimulus (GO:0097067)2.37595581
130purine-containing compound salvage (GO:0043101)2.37431330
131thrombin receptor signaling pathway (GO:0070493)2.37127928
132macromolecular complex disassembly (GO:0032984)2.36902447
133RNA catabolic process (GO:0006401)2.35372909
134positive regulation of extracellular matrix organization (GO:1903055)2.34596070
135definitive hemopoiesis (GO:0060216)2.34193008
136hypotonic response (GO:0006971)2.33641759
137folic acid metabolic process (GO:0046655)2.32796542
138germinal center formation (GO:0002467)2.32052315
139hepatocyte apoptotic process (GO:0097284)2.32002654
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.31631582
141platelet degranulation (GO:0002576)2.31610355
142detection of bacterium (GO:0016045)2.31521944
143myeloid dendritic cell activation (GO:0001773)2.30154708
144decidualization (GO:0046697)2.29884640
145regulation of defense response to virus by virus (GO:0050690)2.29824792
146regulation of T-helper 2 cell differentiation (GO:0045628)2.29291202
147detection of other organism (GO:0098543)2.29190917
148G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.29189146
149UV protection (GO:0009650)2.29136988
150protein retention in ER lumen (GO:0006621)2.29128696
151leukocyte aggregation (GO:0070486)2.28479612
152positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27836697
153positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.27771654
154lipoxygenase pathway (GO:0019372)2.26410145
155regulation of apoptotic process involved in morphogenesis (GO:1902337)2.25972208
156G1/S transition of mitotic cell cycle (GO:0000082)2.25570942
157cell cycle G1/S phase transition (GO:0044843)2.25570942
158maturation of 5.8S rRNA (GO:0000460)2.25277097
159megakaryocyte development (GO:0035855)2.25248426
160regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.24788056
161telomere maintenance (GO:0000723)2.24649698
162cellular component biogenesis (GO:0044085)2.23472225
163telomere organization (GO:0032200)2.23237201
164ribosome assembly (GO:0042255)2.22475342
165neutrophil activation involved in immune response (GO:0002283)2.22309586
166GDP-mannose metabolic process (GO:0019673)2.22077250
167transcription elongation from RNA polymerase III promoter (GO:0006385)2.22044638
168termination of RNA polymerase III transcription (GO:0006386)2.22044638
169response to thyroid hormone (GO:0097066)2.21999767
170negative regulation of viral entry into host cell (GO:0046597)2.21602766
171cellular response to dsRNA (GO:0071359)2.21265485
172L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.20851605
173hemidesmosome assembly (GO:0031581)2.20717545
174platelet dense granule organization (GO:0060155)2.19539211
175retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.19503862
176epithelial cell-cell adhesion (GO:0090136)2.19432672
177response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.18804453
178response to host (GO:0075136)2.18804453
179response to host defenses (GO:0052200)2.18804453
180regulation of natural killer cell differentiation (GO:0032823)2.18131557
181response to protozoan (GO:0001562)2.17642887
182nuclear envelope disassembly (GO:0051081)2.17566661
183membrane disassembly (GO:0030397)2.17566661
184positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.17033108
185response to progesterone (GO:0032570)2.16551664
186defense response to protozoan (GO:0042832)2.16253100
187positive regulation of endothelial cell apoptotic process (GO:2000353)2.15732726
188NIK/NF-kappaB signaling (GO:0038061)2.15618076
189endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.15177777
190proline biosynthetic process (GO:0006561)2.14940824
191exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.13707151
192regulation of respiratory burst (GO:0060263)2.13670733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14447971
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43783328
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.29017270
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.85673653
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.80781416
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.80597838
7ELK3_25401928_ChIP-Seq_HUVEC_Human2.65870256
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.61073055
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53497891
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.46571312
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.44081212
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36182968
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.29594239
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27305440
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25309858
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21479311
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.13827442
18LXR_22292898_ChIP-Seq_THP-1_Human2.12950690
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.11915303
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09356942
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07014472
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.06399723
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04721938
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04263234
25VDR_23849224_ChIP-Seq_CD4+_Human2.03293534
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00511018
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00178744
28RACK7_27058665_Chip-Seq_MCF-7_Human1.98350427
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98090958
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96862372
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96625988
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94762536
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93256874
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91861793
35MYC_22102868_ChIP-Seq_BL_Human1.89545237
36ZNF263_19887448_ChIP-Seq_K562_Human1.82330404
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80524397
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.79802934
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.79537480
40XRN2_22483619_ChIP-Seq_HELA_Human1.79018036
41SPI1_23547873_ChIP-Seq_NB4_Human1.77341892
42TCF7_22412390_ChIP-Seq_EML_Mouse1.77013240
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76485124
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75085117
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74949910
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73212052
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71472944
48VDR_21846776_ChIP-Seq_THP-1_Human1.69081051
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67572903
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.67134284
51FOXP3_21729870_ChIP-Seq_TREG_Human1.67029503
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66313829
53DCP1A_22483619_ChIP-Seq_HELA_Human1.64974278
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64689132
55* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63137190
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62986246
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60687983
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60524663
59GABP_19822575_ChIP-Seq_HepG2_Human1.60149078
60E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58167037
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57684511
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57663243
63SCL_19346495_ChIP-Seq_HPC-7_Human1.56110945
64E2F1_21310950_ChIP-Seq_MCF-7_Human1.56000379
65KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55757010
66KDM2B_26808549_Chip-Seq_DND41_Human1.55379390
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55374106
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.54196726
69ELK1_19687146_ChIP-ChIP_HELA_Human1.53876681
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.53389297
71AR_21909140_ChIP-Seq_LNCAP_Human1.52411487
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51781557
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51684375
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51452580
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50413844
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48060333
77MYB_26560356_Chip-Seq_TH2_Human1.45805216
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45190540
79GATA1_22025678_ChIP-Seq_K562_Human1.44236578
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.44197531
81* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42250130
82NCOR1_26117541_ChIP-Seq_K562_Human1.41594052
83SPI1_23127762_ChIP-Seq_K562_Human1.40464959
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39995593
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39698792
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39680898
87GATA1_19941826_ChIP-Seq_K562_Human1.39533328
88SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39349566
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39034805
90ATF3_27146783_Chip-Seq_COLON_Human1.38499110
91TTF2_22483619_ChIP-Seq_HELA_Human1.37816337
92GATA1_19941827_ChIP-Seq_MEL_Mouse1.35800191
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33955543
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33449632
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32897229
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32789047
97HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30508469
98MYB_26560356_Chip-Seq_TH1_Human1.29283037
99RUNX1_22412390_ChIP-Seq_EML_Mouse1.28782145
100ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27860160
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.26866619
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26823814
103MAF_26560356_Chip-Seq_TH1_Human1.25584490
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24655342
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24366983
106CLOCK_20551151_ChIP-Seq_293T_Human1.24145378
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22691757
108HIF1A_21447827_ChIP-Seq_MCF-7_Human1.21955524
109SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21695107
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.20917286
111TFEB_21752829_ChIP-Seq_HELA_Human1.20385000
112CIITA_25753668_ChIP-Seq_RAJI_Human1.20377198
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19967678
114IRF8_27001747_Chip-Seq_BMDM_Mouse1.19215586
115VDR_24763502_ChIP-Seq_THP-1_Human1.19196230
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19174647
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18572344
118BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18134278
119GATA2_21666600_ChIP-Seq_HMVEC_Human1.17588997
120ELF1_20517297_ChIP-Seq_JURKAT_Human1.16558181
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15095631
122LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14048113
123P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13922296
124GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13296630
125KDM5A_27292631_Chip-Seq_BREAST_Human1.12455722
126SA1_27219007_Chip-Seq_ERYTHROID_Human1.12089790
127P68_20966046_ChIP-Seq_HELA_Human1.12032620
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11871404
129MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11413696
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11221477
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09866014
132BCOR_27268052_Chip-Seq_Bcells_Human1.07414782
133P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06951419
134CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06321451
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06061073
136PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05948007
137UTX_26944678_Chip-Seq_JUKART_Human1.05853539
138STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04933985
139CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04376173
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04346643
141SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04346643
142KDM2B_26808549_Chip-Seq_JURKAT_Human1.03863058
143* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03554313
144BCL6_27268052_Chip-Seq_Bcells_Human1.02179692
145ESR1_21235772_ChIP-Seq_MCF-7_Human1.01363560
146E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01223457
147GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01112805
148ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00718473
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97813892
150POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97770942
151CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96550890
152STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95769132
153ELK1_22589737_ChIP-Seq_MCF10A_Human0.94860911
154THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93639369
155NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93307166
156MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93248484
157RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93090908
158STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92606881
159KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91683724
160MAF_26560356_Chip-Seq_TH2_Human0.91079807
161CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.90016641
162HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89943815

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.56053948
2MP0003705_abnormal_hypodermis_morpholog3.10298543
3MP0001835_abnormal_antigen_presentation3.09492848
4MP0003693_abnormal_embryo_hatching2.75969191
5MP0005451_abnormal_body_composition2.63855401
6MP0006054_spinal_hemorrhage2.27521225
7MP0005671_abnormal_response_to2.23122532
8MP0009333_abnormal_splenocyte_physiolog2.21724307
9MP0004957_abnormal_blastocyst_morpholog2.18771623
10MP0003763_abnormal_thymus_physiology2.18272644
11MP0010094_abnormal_chromosome_stability2.13412504
12MP0003436_decreased_susceptibility_to2.12946446
13MP0009785_altered_susceptibility_to2.11194517
14MP0003724_increased_susceptibility_to2.07042820
15MP0008057_abnormal_DNA_replication2.05363392
16MP0004808_abnormal_hematopoietic_stem2.05161860
17MP0002166_altered_tumor_susceptibility1.98806169
18MP0005397_hematopoietic_system_phenotyp1.96348519
19MP0001545_abnormal_hematopoietic_system1.96348519
20MP0000685_abnormal_immune_system1.94213000
21MP0000490_abnormal_crypts_of1.94180445
22MP0004510_myositis1.91015404
23MP0009840_abnormal_foam_cell1.90950939
24MP0008260_abnormal_autophagy1.90927094
25MP0008007_abnormal_cellular_replicative1.87760099
26MP0005025_abnormal_response_to1.81912947
27MP0003077_abnormal_cell_cycle1.81632369
28MP0001800_abnormal_humoral_immune1.80369720
29MP0002452_abnormal_antigen_presenting1.79762497
30MP0002398_abnormal_bone_marrow1.77105483
31MP0003453_abnormal_keratinocyte_physiol1.76274535
32MP0003111_abnormal_nucleus_morphology1.75768991
33MP0002419_abnormal_innate_immunity1.72368516
34MP0005000_abnormal_immune_tolerance1.72128608
35MP0002420_abnormal_adaptive_immunity1.71801683
36MP0010352_gastrointestinal_tract_polyps1.70315999
37MP0001819_abnormal_immune_cell1.69888585
38MP0002148_abnormal_hypersensitivity_rea1.68256289
39MP0002723_abnormal_immune_serum1.67017313
40MP0002006_tumorigenesis1.64243403
41MP0002796_impaired_skin_barrier1.61169748
42MP0000689_abnormal_spleen_morphology1.60032763
43MP0005464_abnormal_platelet_physiology1.59683819
44MP0000465_gastrointestinal_hemorrhage1.55932110
45MP0002405_respiratory_system_inflammati1.55790468
46MP0008004_abnormal_stomach_pH1.55727192
47MP0010155_abnormal_intestine_physiology1.53958349
48MP0001849_ear_inflammation1.53798806
49MP0002722_abnormal_immune_system1.53392213
50MP0000716_abnormal_immune_system1.51166161
51MP0005501_abnormal_skin_physiology1.48969328
52MP0001853_heart_inflammation1.47104376
53MP0003091_abnormal_cell_migration1.46230083
54MP0005275_abnormal_skin_tensile1.44670979
55MP0002429_abnormal_blood_cell1.44025891
56MP0005076_abnormal_cell_differentiation1.41688812
57MP0001790_abnormal_immune_system1.41653628
58MP0005387_immune_system_phenotype1.41653628
59MP0010234_abnormal_vibrissa_follicle1.40869778
60MP0008058_abnormal_DNA_repair1.37836444
61MP0003186_abnormal_redox_activity1.36594980
62MP0001533_abnormal_skeleton_physiology1.35692837
63MP0001873_stomach_inflammation1.32591044
64MP0005174_abnormal_tail_pigmentation1.32505661
65MP0003172_abnormal_lysosome_physiology1.31156661
66MP0000858_altered_metastatic_potential1.30240224
67MP0001845_abnormal_inflammatory_respons1.29318832
68MP0004272_abnormal_basement_membrane1.28390145
69MP0003300_gastrointestinal_ulcer1.24049170
70MP0005083_abnormal_biliary_tract1.23815507
71MP0008438_abnormal_cutaneous_collagen1.23404260
72MP0005023_abnormal_wound_healing1.22732281
73MP0000703_abnormal_thymus_morphology1.22158504
74MP0003656_abnormal_erythrocyte_physiolo1.21449777
75MP0010307_abnormal_tumor_latency1.21164206
76MP0002019_abnormal_tumor_incidence1.20865285
77MP0003075_altered_response_to1.20386010
78MP0002998_abnormal_bone_remodeling1.18362815
79MP0002132_abnormal_respiratory_system1.18214438
80MP0004947_skin_inflammation1.16604118
81MP0002933_joint_inflammation1.15250190
82MP0003303_peritoneal_inflammation1.14704751
83MP0005058_abnormal_lysosome_morphology1.14351910
84MP0000343_altered_response_to1.14271853
85MP0001851_eye_inflammation1.12656511
86MP0004185_abnormal_adipocyte_glucose1.10637381
87MP0008469_abnormal_protein_level1.09639926
88MP0003786_premature_aging1.09196322
89MP0003806_abnormal_nucleotide_metabolis1.08251790
90MP0000350_abnormal_cell_proliferation1.04310018
91MP0002877_abnormal_melanocyte_morpholog1.04076422
92MP0005165_increased_susceptibility_to1.04005500
93MP0006082_CNS_inflammation1.02906359
94MP0001216_abnormal_epidermal_layer1.02756123
95MP0005075_abnormal_melanosome_morpholog1.02316546
96MP0009931_abnormal_skin_appearance0.99517345
97MP0002095_abnormal_skin_pigmentation0.99488003
98MP0009278_abnormal_bone_marrow0.98065473
99MP0009379_abnormal_foot_pigmentation0.97520103
100MP0005164_abnormal_response_to0.97314470
101MP0005257_abnormal_intraocular_pressure0.96763830
102MP0003448_altered_tumor_morphology0.96170374
103MP0003566_abnormal_cell_adhesion0.94815054
104MP0008932_abnormal_embryonic_tissue0.94503618
105MP0003866_abnormal_defecation0.92434920
106MP0000313_abnormal_cell_death0.92395613
107MP0000015_abnormal_ear_pigmentation0.92242210
108MP0003950_abnormal_plasma_membrane0.89840204
109MP0005390_skeleton_phenotype0.88048038
110MP0000767_abnormal_smooth_muscle0.87597488
111MP0005666_abnormal_adipose_tissue0.87169397
112MP0004233_abnormal_muscle_weight0.87015815
113MP0004782_abnormal_surfactant_physiolog0.86116540
114MP0002060_abnormal_skin_morphology0.85633024
115MP0004147_increased_porphyrin_level0.85494813
116MP0005621_abnormal_cell_physiology0.85271172
117MP0005375_adipose_tissue_phenotype0.83429189
118MP0009384_cardiac_valve_regurgitation0.81643997
119MP0003191_abnormal_cellular_cholesterol0.80941177
120MP0001730_embryonic_growth_arrest0.80732237
121MP0003279_aneurysm0.79944510
122MP0001542_abnormal_bone_strength0.79327297
123MP0000249_abnormal_blood_vessel0.77377147
124MP0004381_abnormal_hair_follicle0.75619160
125MP0001243_abnormal_dermal_layer0.73458980
126MP0003123_paternal_imprinting0.73063377
127MP0001958_emphysema0.71004333
128MP0003943_abnormal_hepatobiliary_system0.70953822
129MP0003795_abnormal_bone_structure0.70023343
130MP0000477_abnormal_intestine_morphology0.67376706
131MP0000598_abnormal_liver_morphology0.66642039
132MP0010368_abnormal_lymphatic_system0.65738397
133MP0009764_decreased_sensitivity_to0.64521181
134MP0009763_increased_sensitivity_to0.63016936
135MP0003828_pulmonary_edema0.61783268

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)4.41341316
2Aplastic anemia (HP:0001915)4.14618436
3Abnormal number of erythroid precursors (HP:0012131)4.02051779
4Abnormality of cells of the erythroid lineage (HP:0012130)3.89935058
5Menorrhagia (HP:0000132)3.81908861
6Premature rupture of membranes (HP:0001788)3.78224604
7Reticulocytopenia (HP:0001896)3.33930782
8Elevated erythrocyte sedimentation rate (HP:0003565)3.25632301
9Eczematoid dermatitis (HP:0000976)3.22699152
10Petechiae (HP:0000967)3.20892498
11Recurrent abscess formation (HP:0002722)3.09220773
12IgM deficiency (HP:0002850)2.98797270
13Chronic otitis media (HP:0000389)2.88945851
14Abnormality of T cell physiology (HP:0011840)2.88599119
15Myositis (HP:0100614)2.87431789
16Distal lower limb muscle weakness (HP:0009053)2.80439898
17Dysostosis multiplex (HP:0000943)2.80380199
18Distal lower limb amyotrophy (HP:0008944)2.73797933
19Recurrent viral infections (HP:0004429)2.68790328
20Cervical subluxation (HP:0003308)2.65312226
21Entropion (HP:0000621)2.63516880
22Recurrent bacterial skin infections (HP:0005406)2.62149661
23Reduced antithrombin III activity (HP:0001976)2.61569845
2411 pairs of ribs (HP:0000878)2.53940430
25Beaking of vertebral bodies (HP:0004568)2.50130674
26Birth length less than 3rd percentile (HP:0003561)2.50007581
27Increased connective tissue (HP:0009025)2.49069928
28Poor head control (HP:0002421)2.46549345
29Pallor (HP:0000980)2.43855151
30Abnormality of glycolipid metabolism (HP:0010969)2.41122637
31Abnormality of liposaccharide metabolism (HP:0010968)2.41122637
32Abnormality of glycosphingolipid metabolism (HP:0004343)2.41122637
33Prolonged bleeding time (HP:0003010)2.41074460
34Oral leukoplakia (HP:0002745)2.39558710
35Abnormality of T cells (HP:0002843)2.39273814
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.37223565
37Increased serum ferritin (HP:0003281)2.36185058
38Pustule (HP:0200039)2.35416216
39Fragile skin (HP:0001030)2.34416667
40Recurrent bronchitis (HP:0002837)2.34053077
41Recurrent fungal infections (HP:0002841)2.30743471
42Vacuolated lymphocytes (HP:0001922)2.29646631
43Nonimmune hydrops fetalis (HP:0001790)2.29366905
44Microretrognathia (HP:0000308)2.28996198
45Achilles tendon contracture (HP:0001771)2.28314942
46Abnormality of the Achilles tendon (HP:0005109)2.27855342
47Hepatosplenomegaly (HP:0001433)2.27170792
48Vertebral compression fractures (HP:0002953)2.27156756
49Dilatation of the ascending aorta (HP:0005111)2.25160154
50Abnormal gallbladder physiology (HP:0012438)2.22395144
51Cholecystitis (HP:0001082)2.22395144
52Type I transferrin isoform profile (HP:0003642)2.20508520
53Hypertensive crisis (HP:0100735)2.19849987
54Broad face (HP:0000283)2.18040157
55Panhypogammaglobulinemia (HP:0003139)2.18018773
56Polycythemia (HP:0001901)2.17379460
57Macrocytic anemia (HP:0001972)2.17342692
58J-shaped sella turcica (HP:0002680)2.16926523
59Atrophic scars (HP:0001075)2.16623888
60Epistaxis (HP:0000421)2.16141787
61Abnormality of polysaccharide metabolism (HP:0011012)2.16073101
62Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16073101
63Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16073101
64Pulmonary fibrosis (HP:0002206)2.16001047
65Loss of speech (HP:0002371)2.14919847
66Autoimmune thrombocytopenia (HP:0001973)2.13034103
67Rough bone trabeculation (HP:0100670)2.13009369
68Osteolytic defects of the hand bones (HP:0009699)2.12397410
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.12397410
70Lymphoma (HP:0002665)2.11522791
71Abnormality of the prostate (HP:0008775)2.11046824
72Mucopolysacchariduria (HP:0008155)2.10990127
73Urinary glycosaminoglycan excretion (HP:0003541)2.10990127
74Bruising susceptibility (HP:0000978)2.10745659
75Pancytopenia (HP:0001876)2.09304160
76Abnormality of B cell number (HP:0010975)2.08234940
77B lymphocytopenia (HP:0010976)2.08234940
78Blue sclerae (HP:0000592)2.05980081
79Degeneration of anterior horn cells (HP:0002398)2.05974579
80Abnormality of the anterior horn cell (HP:0006802)2.05974579
81Spinal rigidity (HP:0003306)2.05693830
82Acute myeloid leukemia (HP:0004808)2.05493028
83Generalized amyotrophy (HP:0003700)2.05480478
84Spondylolisthesis (HP:0003302)2.05456289
85Interstitial pulmonary disease (HP:0006530)2.05233731
86Abnormal platelet volume (HP:0011876)2.04794790
87Recurrent skin infections (HP:0001581)2.04330593
88Fatigue (HP:0012378)2.03722379
89Myocardial infarction (HP:0001658)2.03716857
90Axonal loss (HP:0003447)2.03707558
91Abnormality of macrophages (HP:0004311)2.03259744
92Thoracic kyphosis (HP:0002942)2.02197288
93Periodontitis (HP:0000704)2.01618781
94Ankle contracture (HP:0006466)2.01547332
95Protrusio acetabuli (HP:0003179)2.01238408
96Poikiloderma (HP:0001029)2.00929099
97IgG deficiency (HP:0004315)2.00168732
98Myelodysplasia (HP:0002863)1.99152711
99Abnormality of the lumbar spine (HP:0100712)1.98288766
100Cutaneous melanoma (HP:0012056)1.97624379
101Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97199928
102Abnormal protein N-linked glycosylation (HP:0012347)1.97199928
103Abnormal protein glycosylation (HP:0012346)1.97199928
104Abnormal glycosylation (HP:0012345)1.97199928
105Easy fatigability (HP:0003388)1.97024461
106Hypertriglyceridemia (HP:0002155)1.96636224
107Abnormality of the heme biosynthetic pathway (HP:0010472)1.96291665
108Cerebral aneurysm (HP:0004944)1.95790417
109Increased neuronal autofluorescent lipopigment (HP:0002074)1.92464290
110Abnormality of iron homeostasis (HP:0011031)1.91135330
111Chronic mucocutaneous candidiasis (HP:0002728)1.91049608
112Recurrent cutaneous fungal infections (HP:0011370)1.91049608
113Increased IgE level (HP:0003212)1.91001721
114Abnormality of skeletal muscle fiber size (HP:0012084)1.89557435
115Elbow flexion contracture (HP:0002987)1.89499783
116Short nail (HP:0001799)1.89167902
117Purpura (HP:0000979)1.88740896
118Albinism (HP:0001022)1.87105976
119Aortic dissection (HP:0002647)1.85198974
120Breast hypoplasia (HP:0003187)1.85071757
121Granulocytopenia (HP:0001913)1.85033818
122Increased variability in muscle fiber diameter (HP:0003557)1.84555378
123Aortic aneurysm (HP:0004942)1.84488210
124Joint stiffness (HP:0001387)1.84441413
125Abnormality of the distal phalanges of the toes (HP:0010182)1.84231528
126Colon cancer (HP:0003003)1.83750247
127Abnormality of the thoracic spine (HP:0100711)1.83383451
128Gastrointestinal dysmotility (HP:0002579)1.82793047
129Distal upper limb amyotrophy (HP:0007149)1.81637197
130Upper limb amyotrophy (HP:0009129)1.81637197
131Cellulitis (HP:0100658)1.81114390
132Slender build (HP:0001533)1.79849432
133Trismus (HP:0000211)1.79776331
134Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79181418
135Centrally nucleated skeletal muscle fibers (HP:0003687)1.79063766
136Reduced subcutaneous adipose tissue (HP:0003758)1.78476857
137Osteomyelitis (HP:0002754)1.78223375
138Gingival bleeding (HP:0000225)1.78193287
139Hemorrhage of the eye (HP:0011885)1.78126122
140Agnosia (HP:0010524)1.77712229
141Meningitis (HP:0001287)1.77614467
142Bone marrow hypocellularity (HP:0005528)1.77257597
143Impaired platelet aggregation (HP:0003540)1.76951933
144Abnormal platelet function (HP:0011869)1.76951933
145Multiple enchondromatosis (HP:0005701)1.76444616
146Thin bony cortex (HP:0002753)1.75342511
147Spontaneous hematomas (HP:0007420)1.74515053
148Sparse eyelashes (HP:0000653)1.74001974
149Increased mean platelet volume (HP:0011877)1.73913226
150Eosinophilia (HP:0001880)1.73872597
151Basal ganglia calcification (HP:0002135)1.73556610
152Papilledema (HP:0001085)1.73438921
153Obstructive lung disease (HP:0006536)1.72610022
154Chronic obstructive pulmonary disease (HP:0006510)1.72610022
155Increased density of long bones (HP:0006392)1.72373929
156T lymphocytopenia (HP:0005403)1.71842648
157Increased cerebral lipofuscin (HP:0011813)1.71696501
158Premature graying of hair (HP:0002216)1.71534280
159Wormian bones (HP:0002645)1.70486073
160Peritonitis (HP:0002586)1.70145248
161Nail dystrophy (HP:0008404)1.68666777
162Mitral regurgitation (HP:0001653)1.67277861
163Vascular tortuosity (HP:0004948)1.66318722
164Reticulocytosis (HP:0001923)1.65789168
165Gastrointestinal inflammation (HP:0004386)1.65039240
166Hyperparathyroidism (HP:0000843)1.64323791
167Aneurysm (HP:0002617)1.63936192
168Increased IgM level (HP:0003496)1.63421437
169Bone pain (HP:0002653)1.62253232

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.26956258
2MAP4K13.12261144
3PIM22.93874061
4SIK12.74823782
5PRPF4B2.65752946
6EIF2AK12.54035389
7ACVR1B2.48817627
8BUB12.38383863
9EPHA22.28701722
10TAOK22.23382561
11STK162.18577077
12SMG12.12153376
13KIT2.08855880
14TEC2.04480499
15WEE11.97390864
16LMTK21.93182078
17FLT31.91488748
18JAK31.90515381
19RPS6KA41.89226577
20EEF2K1.85403294
21RIPK41.82723498
22BTK1.76005938
23KDR1.74264435
24EIF2AK31.74251710
25TTN1.62825420
26CDC71.62002239
27ARAF1.60939244
28TYK21.59284621
29MAP2K31.58713000
30SCYL21.58352214
31ZAP701.56791689
32TXK1.56106280
33BRSK21.55932289
34MYLK1.50499703
35IRAK41.46289610
36BMX1.45403459
37TAOK31.44309596
38TGFBR11.43852002
39STK101.42460951
40RPS6KB21.42139650
41TBK11.41572324
42MST1R1.41294349
43EPHB11.41287349
44IRAK31.39389570
45TAOK11.38144868
46SIK31.36659947
47LRRK21.32459491
48VRK11.30583132
49MAP3K111.28974771
50ERN11.25728769
51MAP3K31.24255981
52NEK21.21914666
53CSF1R1.20921412
54ICK1.19468220
55MAP3K11.19156761
56CDK71.18198825
57PIM11.17097121
58MAPKAPK31.15762996
59BLK1.14111710
60NEK91.13602211
61ILK1.09332449
62IKBKB1.08269428
63IKBKE1.00296421
64PTK21.00155919
65PRKD20.99887999
66IRAK20.99622410
67PASK0.99577647
68MKNK10.99567073
69MAP3K140.98632322
70SRPK10.97537723
71TSSK60.94039464
72CDK80.93970663
73SYK0.93810556
74RIPK10.92053713
75TGFBR20.91344086
76MAP3K80.90666393
77AURKB0.90616902
78LIMK10.87221406
79TESK20.85164471
80ITK0.84907076
81ATR0.83203529
82PAK40.82625213
83PTK60.81150059
84MST40.80558527
85DYRK30.78840555
86MAP3K130.77179442
87TRPM70.76851454
88HIPK20.76758577
89PLK40.76647429
90CDK40.75804461
91PDGFRA0.75079398
92LYN0.75009465
93PKN20.74586482
94PDPK10.74001907
95CDC42BPA0.73995670
96LCK0.72258733
97EPHA30.71215979
98MOS0.70599334
99BRAF0.68963436
100NLK0.68324844
101MAPK110.66471766
102EPHB20.66424705
103PAK10.63953291
104BCKDK0.63594534
105KSR20.62844048
106PTK2B0.61856182
107MAP3K60.61588233
108ZAK0.61387801
109MAP3K120.60943476
110TESK10.60462492
111STK30.59129690
112JAK10.58613604
113PLK10.58598749
114DDR20.58523814
115TNK20.57779523
116TRIB30.57769439
117RAF10.57707476
118CDK120.57038108
119VRK20.56710248
120ABL20.56427165
121TTK0.55119644
122STK240.54827725
123RPS6KA20.53401952
124CHUK0.52476097
125MAP3K100.50835027
126EIF2AK20.49711117
127STK40.49565217
128BRSK10.49422260
129HCK0.48960245
130MTOR0.47442534
131CLK10.47434160
132PRKG20.47242602
133CSK0.45850694
134MAP2K20.45770315
135GRK60.45594964
136STK380.45587965
137RPS6KA60.45192927
138MARK20.44443672
139CHEK20.44056407
140PIK3CG0.43486353
141BMPR20.43447000
142MAPKAPK50.43219329
143CDK60.43183012
144MAPKAPK20.42980851
145MKNK20.42911773
146IRAK10.42629551
147MATK0.42525812
148PDK10.41657724
149MET0.41421943
150MAP3K50.41412584
151FGFR40.41151381
152RPS6KC10.40894834
153RPS6KL10.40894834
154DAPK30.39899269

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.16077655
2Ribosome_Homo sapiens_hsa030103.32062419
3Mismatch repair_Homo sapiens_hsa034303.05399441
4Base excision repair_Homo sapiens_hsa034102.67652171
5RNA polymerase_Homo sapiens_hsa030202.54855820
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.47309160
7Homologous recombination_Homo sapiens_hsa034402.35216999
8Proteasome_Homo sapiens_hsa030502.30750073
9Pyrimidine metabolism_Homo sapiens_hsa002402.22148710
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15268506
11Nucleotide excision repair_Homo sapiens_hsa034202.12707815
12One carbon pool by folate_Homo sapiens_hsa006701.89451512
13Protein export_Homo sapiens_hsa030601.80100049
14Antigen processing and presentation_Homo sapiens_hsa046121.79644788
15Bladder cancer_Homo sapiens_hsa052191.77270889
16Cell cycle_Homo sapiens_hsa041101.75578591
17Spliceosome_Homo sapiens_hsa030401.75402199
18Non-homologous end-joining_Homo sapiens_hsa034501.73399755
19RNA transport_Homo sapiens_hsa030131.66444063
20Primary immunodeficiency_Homo sapiens_hsa053401.58181033
21Non-small cell lung cancer_Homo sapiens_hsa052231.52702020
22Herpes simplex infection_Homo sapiens_hsa051681.42203745
23p53 signaling pathway_Homo sapiens_hsa041151.39658193
24RNA degradation_Homo sapiens_hsa030181.38457224
25Legionellosis_Homo sapiens_hsa051341.36454819
26Leishmaniasis_Homo sapiens_hsa051401.34067886
27Folate biosynthesis_Homo sapiens_hsa007901.32857561
28Other glycan degradation_Homo sapiens_hsa005111.30873724
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.30779147
30Endocytosis_Homo sapiens_hsa041441.28167958
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26927016
32N-Glycan biosynthesis_Homo sapiens_hsa005101.25894615
33Focal adhesion_Homo sapiens_hsa045101.25844719
34Measles_Homo sapiens_hsa051621.25838826
35ECM-receptor interaction_Homo sapiens_hsa045121.24026001
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.21613462
37VEGF signaling pathway_Homo sapiens_hsa043701.20789247
38Vibrio cholerae infection_Homo sapiens_hsa051101.19790222
39Hematopoietic cell lineage_Homo sapiens_hsa046401.17344267
40Pentose phosphate pathway_Homo sapiens_hsa000301.16844605
41Caffeine metabolism_Homo sapiens_hsa002321.15877048
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.14870706
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12943429
44Amoebiasis_Homo sapiens_hsa051461.12129543
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12127336
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.11152301
47Purine metabolism_Homo sapiens_hsa002301.10784255
48Fructose and mannose metabolism_Homo sapiens_hsa000511.09524631
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09408608
50Endometrial cancer_Homo sapiens_hsa052131.07465010
51Renal cell carcinoma_Homo sapiens_hsa052111.06736849
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.06114431
53Epstein-Barr virus infection_Homo sapiens_hsa051691.04175706
54Basal transcription factors_Homo sapiens_hsa030221.02904193
55Phagosome_Homo sapiens_hsa041451.02705330
56Notch signaling pathway_Homo sapiens_hsa043301.01329728
57Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00437862
58Proteoglycans in cancer_Homo sapiens_hsa052050.99687802
59Fanconi anemia pathway_Homo sapiens_hsa034600.98992471
60Sulfur relay system_Homo sapiens_hsa041220.97719660
61Shigellosis_Homo sapiens_hsa051310.94448285
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93490942
63Apoptosis_Homo sapiens_hsa042100.91311025
64Malaria_Homo sapiens_hsa051440.89154876
65Chemokine signaling pathway_Homo sapiens_hsa040620.88391913
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87971348
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86725924
68Hepatitis B_Homo sapiens_hsa051610.86079284
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.85151073
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84517611
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82320486
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.81954263
73Influenza A_Homo sapiens_hsa051640.81919492
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81689066
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.79589548
76B cell receptor signaling pathway_Homo sapiens_hsa046620.79534380
77Pertussis_Homo sapiens_hsa051330.79263304
78Lysosome_Homo sapiens_hsa041420.78774231
79Small cell lung cancer_Homo sapiens_hsa052220.78679818
80Osteoclast differentiation_Homo sapiens_hsa043800.77892825
81Viral carcinogenesis_Homo sapiens_hsa052030.75775992
82Toxoplasmosis_Homo sapiens_hsa051450.73870947
83HTLV-I infection_Homo sapiens_hsa051660.71828206
84Glioma_Homo sapiens_hsa052140.71507505
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.71441515
86Prostate cancer_Homo sapiens_hsa052150.70731001
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69517202
88Allograft rejection_Homo sapiens_hsa053300.69000742
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68384623
90Glutathione metabolism_Homo sapiens_hsa004800.67668605
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67500673
92Prion diseases_Homo sapiens_hsa050200.67499153
93Thyroid cancer_Homo sapiens_hsa052160.67075403
94Acute myeloid leukemia_Homo sapiens_hsa052210.67031733
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.65921285
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65739509
97Galactose metabolism_Homo sapiens_hsa000520.65518726
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65270449
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.63646829
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63283897
101Insulin signaling pathway_Homo sapiens_hsa049100.63159292
102Selenocompound metabolism_Homo sapiens_hsa004500.61511149
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60928597
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60632796
105Viral myocarditis_Homo sapiens_hsa054160.59784700
106Tuberculosis_Homo sapiens_hsa051520.59232628
107Insulin resistance_Homo sapiens_hsa049310.58503305
108TNF signaling pathway_Homo sapiens_hsa046680.57831445
109HIF-1 signaling pathway_Homo sapiens_hsa040660.56027380
110mTOR signaling pathway_Homo sapiens_hsa041500.54786615
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.54408493
112Inositol phosphate metabolism_Homo sapiens_hsa005620.53053381
113Chronic myeloid leukemia_Homo sapiens_hsa052200.51474337
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51436907
115Colorectal cancer_Homo sapiens_hsa052100.50470857
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49975977
117Melanoma_Homo sapiens_hsa052180.49927146
118Graft-versus-host disease_Homo sapiens_hsa053320.49710166
119Sphingolipid metabolism_Homo sapiens_hsa006000.49665117
120ErbB signaling pathway_Homo sapiens_hsa040120.49067413
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48700783
122Staphylococcus aureus infection_Homo sapiens_hsa051500.48591480
123Arachidonic acid metabolism_Homo sapiens_hsa005900.47306190
124Pancreatic cancer_Homo sapiens_hsa052120.45425076
125Platelet activation_Homo sapiens_hsa046110.44085423
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42765814
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.42114251
128Salmonella infection_Homo sapiens_hsa051320.41782579
129Asthma_Homo sapiens_hsa053100.40954836
130Renin-angiotensin system_Homo sapiens_hsa046140.40616931
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37514434
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36425356
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35762450
134Hepatitis C_Homo sapiens_hsa051600.35075022
135T cell receptor signaling pathway_Homo sapiens_hsa046600.34862249
136Vitamin B6 metabolism_Homo sapiens_hsa007500.34107116
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33337580
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32703374
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31840568
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31461938

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