SLC10A4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alkaloid metabolic process (GO:0009820)9.76383066
2catecholamine transport (GO:0051937)9.36977322
3catechol-containing compound biosynthetic process (GO:0009713)8.40641165
4catecholamine biosynthetic process (GO:0042423)8.40641165
5neurotransmitter biosynthetic process (GO:0042136)7.18107008
6neurotransmitter catabolic process (GO:0042135)7.12926266
7dopamine metabolic process (GO:0042417)7.09133853
8response to insecticide (GO:0017085)6.64786755
9regulation of dopamine metabolic process (GO:0042053)6.51862630
10regulation of catecholamine metabolic process (GO:0042069)6.51862630
11behavioral response to nicotine (GO:0035095)6.38316750
12monoamine transport (GO:0015844)6.06077064
13mating behavior (GO:0007617)6.02612790
14synaptic transmission, cholinergic (GO:0007271)5.71962661
15synaptic transmission, dopaminergic (GO:0001963)5.63759838
16neurotransmitter metabolic process (GO:0042133)5.56301092
17phenol-containing compound biosynthetic process (GO:0046189)5.52761821
18neuron cell-cell adhesion (GO:0007158)5.44281423
19toxin metabolic process (GO:0009404)5.15471986
20prepulse inhibition (GO:0060134)5.07873231
21catecholamine metabolic process (GO:0006584)4.94906433
22catechol-containing compound metabolic process (GO:0009712)4.94906433
23synaptic vesicle exocytosis (GO:0016079)4.94053734
24negative regulation of microtubule polymerization (GO:0031115)4.92982367
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.71843616
26serotonin metabolic process (GO:0042428)4.70888719
27negative regulation of neurotransmitter transport (GO:0051589)4.60170578
28response to amphetamine (GO:0001975)4.57946266
29cellular response to nicotine (GO:0071316)4.57646420
30primary amino compound metabolic process (GO:1901160)4.55483608
31response to cocaine (GO:0042220)4.55165313
32regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.52793834
33regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.52793834
34regulation of dopamine secretion (GO:0014059)4.49087293
35behavioral response to ethanol (GO:0048149)4.44607081
36norepinephrine metabolic process (GO:0042415)4.43518655
37regulation of neurotransmitter levels (GO:0001505)4.38362979
38glutamate secretion (GO:0014047)4.35013404
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.32702490
40neurotransmitter secretion (GO:0007269)4.29835179
41regulation of short-term neuronal synaptic plasticity (GO:0048172)4.17282342
42behavioral response to cocaine (GO:0048148)4.14957406
43response to water (GO:0009415)4.06701779
44multicellular organismal aging (GO:0010259)4.03610397
45neurotransmitter transport (GO:0006836)4.03111562
46microtubule depolymerization (GO:0007019)3.91284631
47sympathetic nervous system development (GO:0048485)3.89491334
48pyrimidine nucleobase catabolic process (GO:0006208)3.88831795
49DNA double-strand break processing (GO:0000729)3.85456943
50regulation of synaptic transmission, dopaminergic (GO:0032225)3.82848068
51neuromuscular synaptic transmission (GO:0007274)3.79209088
52synapsis (GO:0007129)3.78318825
53enteric nervous system development (GO:0048484)3.77965557
54dopaminergic neuron differentiation (GO:0071542)3.65397173
55peripheral nervous system neuron development (GO:0048935)3.64063166
56establishment of synaptic vesicle localization (GO:0097480)3.58696182
57synaptic vesicle transport (GO:0048489)3.58696182
58vocalization behavior (GO:0071625)3.55287406
59response to nicotine (GO:0035094)3.54491488
60resolution of meiotic recombination intermediates (GO:0000712)3.54348474
61response to corticosterone (GO:0051412)3.53053452
62chromatin remodeling at centromere (GO:0031055)3.50317500
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.50198053
64regulation of vesicle fusion (GO:0031338)3.49165073
65presynaptic membrane assembly (GO:0097105)3.48926551
66kinetochore organization (GO:0051383)3.48862448
67response to amine (GO:0014075)3.45217344
68tyrosine metabolic process (GO:0006570)3.43634355
69mechanosensory behavior (GO:0007638)3.43011536
70CENP-A containing nucleosome assembly (GO:0034080)3.42117932
71positive regulation of neurotransmitter transport (GO:0051590)3.41489704
72mitotic sister chromatid segregation (GO:0000070)3.35630005
73DNA replication-dependent nucleosome organization (GO:0034723)3.34143564
74DNA replication-dependent nucleosome assembly (GO:0006335)3.34143564
75glycoside metabolic process (GO:0016137)3.33185095
76kinetochore assembly (GO:0051382)3.32697777
77sister chromatid segregation (GO:0000819)3.31241256
78synaptic vesicle maturation (GO:0016188)3.31088615
79regulation of oxidative phosphorylation (GO:0002082)3.26101576
80neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.25638570
81neuron maturation (GO:0042551)3.20438132
82regulation of neurotransmitter uptake (GO:0051580)3.17868998
83male meiosis (GO:0007140)3.17139588
84cell migration in hindbrain (GO:0021535)3.16563404
85proline transport (GO:0015824)3.15446495
86DNA replication-independent nucleosome organization (GO:0034724)3.15267773
87DNA replication-independent nucleosome assembly (GO:0006336)3.15267773
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14383683
89regulation of respiratory gaseous exchange (GO:0043576)3.13052378
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12326478
91DNA topological change (GO:0006265)3.12236356
92postsynaptic membrane organization (GO:0001941)3.11155233
93positive regulation of cell size (GO:0045793)3.10732952
94regulation of synapse structural plasticity (GO:0051823)3.09899426
95opioid receptor signaling pathway (GO:0038003)3.05193777
96regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04970861
97striatum development (GO:0021756)3.01475531
98regulation of neurotransmitter transport (GO:0051588)3.00987366
99regulation of mitochondrial translation (GO:0070129)2.99776664
100cerebellar Purkinje cell layer development (GO:0021680)2.98231138
101establishment of mitochondrion localization (GO:0051654)2.97945811
102positive regulation of glomerulus development (GO:0090193)2.97357484
103energy coupled proton transport, down electrochemical gradient (GO:0015985)2.97009178
104ATP synthesis coupled proton transport (GO:0015986)2.97009178
105auditory behavior (GO:0031223)2.96095830
106presynaptic membrane organization (GO:0097090)2.96081896
107viral mRNA export from host cell nucleus (GO:0046784)2.94540353
108response to mineralocorticoid (GO:0051385)2.93120274
109response to pain (GO:0048265)2.92585810
110histone exchange (GO:0043486)2.92075590
111regulation of synaptic vesicle exocytosis (GO:2000300)2.91554011
112exploration behavior (GO:0035640)2.91409050
113multi-organism reproductive behavior (GO:0044705)2.90764814
114replication fork processing (GO:0031297)2.90666464
115protein localization to chromosome (GO:0034502)2.89452380
116energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.89170161
117ATP hydrolysis coupled proton transport (GO:0015991)2.89170161
118DNA damage response, detection of DNA damage (GO:0042769)2.88169931
119positive regulation of vesicle fusion (GO:0031340)2.87517317
120protein localization to synapse (GO:0035418)2.85102895
121reproductive behavior (GO:0019098)2.85018295
122attachment of spindle microtubules to kinetochore (GO:0008608)2.83782621
123nucleobase catabolic process (GO:0046113)2.82199380
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.81539808
125translesion synthesis (GO:0019985)2.80014263
126chromosome organization involved in meiosis (GO:0070192)2.79755497
127neuromuscular process controlling posture (GO:0050884)2.78151234
128locomotory behavior (GO:0007626)2.76205058
129sensory perception of smell (GO:0007608)2.75674643
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.74623222
131mitochondrion transport along microtubule (GO:0047497)2.74623222
132establishment of protein localization to mitochondrial membrane (GO:0090151)2.74025342
133electron transport chain (GO:0022900)2.73487597
134male meiosis I (GO:0007141)2.70009318
135positive regulation of growth hormone secretion (GO:0060124)2.67991416
136outer ear morphogenesis (GO:0042473)2.67493140
137neuron recognition (GO:0008038)2.66186458
138regulation of nuclear cell cycle DNA replication (GO:0033262)2.66013481
139positive regulation of RNA splicing (GO:0033120)2.62692185
140regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.61193218
141maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61150190
142protoporphyrinogen IX metabolic process (GO:0046501)2.60597307
143protein polyglutamylation (GO:0018095)2.60534365
144positive regulation of dendritic spine morphogenesis (GO:0061003)2.58747724
145microtubule polymerization or depolymerization (GO:0031109)2.58651375
146mitochondrial respiratory chain complex assembly (GO:0033108)2.57934689
147regulation of transcription regulatory region DNA binding (GO:2000677)2.55641222
148cardiac ventricle formation (GO:0003211)2.55533684
149protein localization to kinetochore (GO:0034501)2.55110419
150positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.54833609
151piRNA metabolic process (GO:0034587)2.52714103
152DNA unwinding involved in DNA replication (GO:0006268)2.52371172
153protoporphyrinogen IX biosynthetic process (GO:0006782)2.51453702
154protein complex biogenesis (GO:0070271)2.50839842
155mitotic metaphase plate congression (GO:0007080)2.47814341
156growth hormone secretion (GO:0030252)2.47339141
157protein localization to chromosome, centromeric region (GO:0071459)2.45244365
158negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44553607
159nonmotile primary cilium assembly (GO:0035058)2.44543245
160DNA synthesis involved in DNA repair (GO:0000731)2.44525766
161positive regulation of cell cycle G2/M phase transition (GO:1902751)2.44197663
162positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.44197663
163negative regulation of DNA recombination (GO:0045910)2.43334021
164protein K6-linked ubiquitination (GO:0085020)2.39654502
165histone H2A acetylation (GO:0043968)2.39436873
166protein localization to cilium (GO:0061512)2.39328636
167chaperone-mediated protein complex assembly (GO:0051131)2.38490892
168cardiac chamber formation (GO:0003207)2.37728975
169response to auditory stimulus (GO:0010996)2.37508156
170metaphase plate congression (GO:0051310)2.37220179
171peptidyl-arginine methylation (GO:0018216)2.36308771
172peptidyl-arginine N-methylation (GO:0035246)2.36308771
173spindle checkpoint (GO:0031577)2.36299741
174chromatin assembly or disassembly (GO:0006333)2.35887056
175peptidyl-arginine omega-N-methylation (GO:0035247)2.34903879
176lipopolysaccharide biosynthetic process (GO:0009103)2.34554167
177mitotic spindle checkpoint (GO:0071174)2.34229927
178meiosis I (GO:0007127)2.33344567
179positive regulation of cell cycle checkpoint (GO:1901978)2.33186052
180regulation of microtubule polymerization (GO:0031113)2.32892100
181mitotic chromosome condensation (GO:0007076)2.32748495
182dopamine biosynthetic process (GO:0042416)11.7889264
183dopamine transport (GO:0015872)11.2776969
184phenol-containing compound catabolic process (GO:0019336)11.2365602

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.13138245
2E2F7_22180533_ChIP-Seq_HELA_Human4.93311463
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.87435509
4TAF15_26573619_Chip-Seq_HEK293_Human3.66437007
5GBX2_23144817_ChIP-Seq_PC3_Human3.21514248
6* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.17267647
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.14428958
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12962662
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.05310377
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.95638446
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93769761
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83016543
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.79571563
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71008839
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.69277535
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68322739
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.65414041
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.62477105
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58286980
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.58086672
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56615425
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56343376
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56343376
24NR3C1_23031785_ChIP-Seq_PC12_Mouse2.49105527
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48106869
26REST_21632747_ChIP-Seq_MESCs_Mouse2.43886229
27BMI1_23680149_ChIP-Seq_NPCS_Mouse2.42048301
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37182708
29* EZH2_27304074_Chip-Seq_ESCs_Mouse2.37136665
30IGF1R_20145208_ChIP-Seq_DFB_Human2.36242777
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34101077
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31091643
33MYC_18555785_ChIP-Seq_MESCs_Mouse2.29555024
34SALL1_21062744_ChIP-ChIP_HESCs_Human2.28279576
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27200410
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20694231
37REST_18959480_ChIP-ChIP_MESCs_Mouse2.14529382
38* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13860593
39CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04962100
40ZNF274_21170338_ChIP-Seq_K562_Hela1.98739328
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97344778
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.96635719
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.94919602
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94103225
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92446516
46* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91451600
47DROSHA_22980978_ChIP-Seq_HELA_Human1.84850895
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82369729
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79100670
50AR_21572438_ChIP-Seq_LNCaP_Human1.78004978
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.77027338
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.73380624
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.72081610
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71551941
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71128517
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69668474
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.69293564
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63236078
59AR_21909140_ChIP-Seq_LNCAP_Human1.60544159
60P300_19829295_ChIP-Seq_ESCs_Human1.60185773
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59092417
62VDR_22108803_ChIP-Seq_LS180_Human1.58159709
63MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57868279
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57862559
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56085804
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54086979
67ETS1_20019798_ChIP-Seq_JURKAT_Human1.52888795
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51355050
69ELK1_19687146_ChIP-ChIP_HELA_Human1.49797675
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49189081
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.48528372
72TTF2_22483619_ChIP-Seq_HELA_Human1.46168428
73* SMAD4_21799915_ChIP-Seq_A2780_Human1.46072729
74BCAT_22108803_ChIP-Seq_LS180_Human1.44288923
75RARB_27405468_Chip-Seq_BRAIN_Mouse1.44009155
76IRF1_19129219_ChIP-ChIP_H3396_Human1.41616862
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.38925612
78CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.38434326
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37157257
80MYC_18940864_ChIP-ChIP_HL60_Human1.31845884
81XRN2_22483619_ChIP-Seq_HELA_Human1.31367069
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.30985264
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30832330
84* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30662316
85* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26368637
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.25174284
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.25095910
88RNF2_27304074_Chip-Seq_NSC_Mouse1.23612773
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23560592
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.23233521
91MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21602322
92NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20822835
93MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18486966
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18199665
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18038361
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.17877845
97AR_25329375_ChIP-Seq_VCAP_Human1.17680840
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16585055
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15485490
100RING1B_27294783_Chip-Seq_ESCs_Mouse1.12950456
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12915937
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12871457
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12727296
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11899995
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11787748
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11782642
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11600457
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11600457
109MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11429125
110FUS_26573619_Chip-Seq_HEK293_Human1.10988272
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10069478
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08960773
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08077311
114RUNX2_22187159_ChIP-Seq_PCA_Human1.07870297
115DCP1A_22483619_ChIP-Seq_HELA_Human1.01480656
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.01400338
117VDR_23849224_ChIP-Seq_CD4+_Human1.01318149
118GATA1_26923725_Chip-Seq_HPCs_Mouse1.01222917
119TP53_22573176_ChIP-Seq_HFKS_Human1.00301574
120DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99838827
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99352678
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98920080
123ER_23166858_ChIP-Seq_MCF-7_Human0.98238562
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97971912
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97546307
126EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96640098
127FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96557602
128* JUN_21703547_ChIP-Seq_K562_Human0.96422297
129SOX9_26525672_Chip-Seq_HEART_Mouse0.96343791
130RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95112064
131PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94465999
132* PRDM14_20953172_ChIP-Seq_ESCs_Human0.93929554
133STAT3_23295773_ChIP-Seq_U87_Human0.93681476
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93305553
135OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92867761
136PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92726102
137MYC_19079543_ChIP-ChIP_MESCs_Mouse0.92449622
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91489944
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90402517
140SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90189087
141EWS_26573619_Chip-Seq_HEK293_Human0.90101213
142HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89586108
143EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87472041
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87097804
145ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87072208
146TP53_18474530_ChIP-ChIP_U2OS_Human0.86345153
147WT1_19549856_ChIP-ChIP_CCG9911_Human0.85527850
148CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85227245
149CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85060593
150MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84844764
151KLF5_20875108_ChIP-Seq_MESCs_Mouse0.84781867
152TCF4_23295773_ChIP-Seq_U87_Human0.84561824
153CTCF_27219007_Chip-Seq_Bcells_Human0.84432190
154RING1B_27294783_Chip-Seq_NPCs_Mouse0.84224632
155AR_19668381_ChIP-Seq_PC3_Human0.81314434
156GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81296501
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80473412
158TP53_16413492_ChIP-PET_HCT116_Human0.80265896
159POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.79690098
160REST_19997604_ChIP-ChIP_NEURONS_Mouse0.78475964
161TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.78251498
162RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78195493
163MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.77068403

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy6.41175884
2MP0001905_abnormal_dopamine_level5.39686988
3MP0006276_abnormal_autonomic_nervous4.58686991
4MP0001529_abnormal_vocalization4.48186755
5MP0003880_abnormal_central_pattern3.95039363
6MP0004859_abnormal_synaptic_plasticity3.08003252
7MP0003122_maternal_imprinting2.89822601
8MP0003635_abnormal_synaptic_transmissio2.88716619
9MP0009046_muscle_twitch2.73452731
10MP0009745_abnormal_behavioral_response2.67176055
11MP0001501_abnormal_sleep_pattern2.66569399
12MP0003567_abnormal_fetal_cardiomyocyte2.66507403
13MP0002638_abnormal_pupillary_reflex2.65361832
14MP0005386_behavior/neurological_phenoty2.45995767
15MP0004924_abnormal_behavior2.45995767
16MP0010386_abnormal_urinary_bladder2.37418286
17MP0005423_abnormal_somatic_nervous2.36874989
18MP0008877_abnormal_DNA_methylation2.34324834
19MP0002064_seizures2.34211572
20MP0002139_abnormal_hepatobiliary_system2.34109268
21MP0002572_abnormal_emotion/affect_behav2.33169657
22MP0002909_abnormal_adrenal_gland2.30478713
23MP0002733_abnormal_thermal_nociception2.23804472
24MP0010094_abnormal_chromosome_stability2.22463807
25MP0008872_abnormal_physiological_respon2.17179387
26MP0002063_abnormal_learning/memory/cond2.15526905
27MP0000538_abnormal_urinary_bladder2.08861895
28MP0001440_abnormal_grooming_behavior2.08362123
29MP0004270_analgesia2.06218876
30MP0002734_abnormal_mechanical_nocicepti1.99977574
31MP0000049_abnormal_middle_ear1.99959672
32MP0001188_hyperpigmentation1.96642252
33MP0008789_abnormal_olfactory_epithelium1.87806367
34MP0005409_darkened_coat_color1.86074757
35MP0002272_abnormal_nervous_system1.83544921
36MP0002751_abnormal_autonomic_nervous1.81795468
37MP0002184_abnormal_innervation1.81273511
38MP0001970_abnormal_pain_threshold1.80729865
39MP0003937_abnormal_limbs/digits/tail_de1.80663793
40MP0008058_abnormal_DNA_repair1.80640128
41MP0004147_increased_porphyrin_level1.78136103
42MP0002653_abnormal_ependyma_morphology1.68400224
43MP0002557_abnormal_social/conspecific_i1.67694155
44MP0001486_abnormal_startle_reflex1.66487368
45MP0000569_abnormal_digit_pigmentation1.64957364
46MP0003111_abnormal_nucleus_morphology1.62069489
47MP0001968_abnormal_touch/_nociception1.59348621
48MP0002009_preneoplasia1.58647873
49MP0005535_abnormal_body_temperature1.54554873
50MP0005645_abnormal_hypothalamus_physiol1.53461818
51MP0000566_synostosis1.49924222
52MP0002067_abnormal_sensory_capabilities1.48420825
53MP0000778_abnormal_nervous_system1.36445912
54MP0003718_maternal_effect1.36380630
55MP0005646_abnormal_pituitary_gland1.36372078
56MP0002332_abnormal_exercise_endurance1.35255564
57MP0003077_abnormal_cell_cycle1.35170067
58MP0005171_absent_coat_pigmentation1.30539586
59MP0001664_abnormal_digestion1.29296347
60MP0008995_early_reproductive_senescence1.29112950
61MP0003861_abnormal_nervous_system1.28983424
62MP0000955_abnormal_spinal_cord1.27835555
63MP0004811_abnormal_neuron_physiology1.26246619
64MP0004142_abnormal_muscle_tone1.26067372
65MP0000516_abnormal_urinary_system1.25033334
66MP0005367_renal/urinary_system_phenotyp1.25033334
67MP0003693_abnormal_embryo_hatching1.25022697
68MP0002233_abnormal_nose_morphology1.20947258
69MP0002736_abnormal_nociception_after1.19226921
70MP0008932_abnormal_embryonic_tissue1.18394016
71MP0002066_abnormal_motor_capabilities/c1.16732720
72MP0002735_abnormal_chemical_nociception1.15682941
73MP0004858_abnormal_nervous_system1.13755785
74MP0005248_abnormal_Harderian_gland1.13035829
75MP0004957_abnormal_blastocyst_morpholog1.11959066
76MP0002697_abnormal_eye_size1.08945650
77MP0001293_anophthalmia1.08906934
78MP0002882_abnormal_neuron_morphology1.06248578
79MP0006292_abnormal_olfactory_placode1.04741581
80MP0003385_abnormal_body_wall1.04411559
81MP0002210_abnormal_sex_determination1.04336150
82MP0000631_abnormal_neuroendocrine_gland1.03104224
83MP0000751_myopathy1.01939926
84MP0005551_abnormal_eye_electrophysiolog0.99881921
85MP0005253_abnormal_eye_physiology0.99010952
86MP0002837_dystrophic_cardiac_calcinosis0.96720990
87MP0003755_abnormal_palate_morphology0.95311289
88MP0003632_abnormal_nervous_system0.94443678
89MP0008569_lethality_at_weaning0.93787318
90MP0002938_white_spotting0.93635326
91MP0001929_abnormal_gametogenesis0.92594442
92MP0000647_abnormal_sebaceous_gland0.92521595
93MP0003698_abnormal_male_reproductive0.92494498
94MP0003631_nervous_system_phenotype0.90279231
95MP0000639_abnormal_adrenal_gland0.90247967
96MP0003935_abnormal_craniofacial_develop0.89693578
97MP0002090_abnormal_vision0.87368203
98MP0000579_abnormal_nail_morphology0.87249880
99MP0009379_abnormal_foot_pigmentation0.86618633
100MP0003787_abnormal_imprinting0.84902134
101MP0001502_abnormal_circadian_rhythm0.83690848
102MP0000026_abnormal_inner_ear0.83580491
103MP0003656_abnormal_erythrocyte_physiolo0.83455919
104MP0008874_decreased_physiological_sensi0.83280202
105MP0001346_abnormal_lacrimal_gland0.82649491
106MP0003868_abnormal_feces_composition0.82254302
107MP0002085_abnormal_embryonic_tissue0.82021333
108MP0001286_abnormal_eye_development0.81149737
109MP0002152_abnormal_brain_morphology0.81136902
110MP0002084_abnormal_developmental_patter0.80411787
111MP0003123_paternal_imprinting0.79452310
112MP0003943_abnormal_hepatobiliary_system0.78361122
113MP0009250_abnormal_appendicular_skeleto0.78305833
114MP0002069_abnormal_eating/drinking_beha0.78041655
115MP0001672_abnormal_embryogenesis/_devel0.77992119
116MP0005380_embryogenesis_phenotype0.77992119
117MP0000537_abnormal_urethra_morphology0.77532111
118MP0003942_abnormal_urinary_system0.75903912
119MP0000653_abnormal_sex_gland0.75727450
120MP0005394_taste/olfaction_phenotype0.75550325
121MP0005499_abnormal_olfactory_system0.75550325
122MP0003938_abnormal_ear_development0.75278373
123MP0003121_genomic_imprinting0.75095788
124MP0002249_abnormal_larynx_morphology0.74382451
125MP0000534_abnormal_ureter_morphology0.74305632
126MP0003633_abnormal_nervous_system0.71203680
127MP0002163_abnormal_gland_morphology0.70556922
128MP0000747_muscle_weakness0.70259657
129MP0001984_abnormal_olfaction0.70138275
130MP0003329_amyloid_beta_deposits0.69928514
131MP0004085_abnormal_heartbeat0.68720111
132MP0002752_abnormal_somatic_nervous0.67731436
133MP0001943_abnormal_respiration0.65938949
134MP0005197_abnormal_uvea_morphology0.65009859
135MP0004883_abnormal_blood_vessel0.64585498
136MP0005187_abnormal_penis_morphology0.63235116
137MP0003183_abnormal_peptide_metabolism0.62552624
138MP0004742_abnormal_vestibular_system0.61753404
139MP0001340_abnormal_eyelid_morphology0.61152533
140MP0001177_atelectasis0.59720430
141MP0002229_neurodegeneration0.59100957
142MP0002102_abnormal_ear_morphology0.57732499
143MP0005379_endocrine/exocrine_gland_phen0.55453866
144MP0001299_abnormal_eye_distance/0.54371525
145MP0002127_abnormal_cardiovascular_syste0.54049192
146MP0001270_distended_abdomen0.54045400
147MP0006035_abnormal_mitochondrial_morpho0.53657385
148MP0003866_abnormal_defecation0.53296596
149MP0001881_abnormal_mammary_gland0.52779022
150MP0006072_abnormal_retinal_apoptosis0.48171389
151MP0000013_abnormal_adipose_tissue0.47882859

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)9.56370835
2Pheochromocytoma (HP:0002666)6.19781254
3Neuroendocrine neoplasm (HP:0100634)5.55381545
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.35728705
5Myokymia (HP:0002411)5.04095398
6Visual hallucinations (HP:0002367)4.90771516
7Failure to thrive in infancy (HP:0001531)4.63155308
8Abnormal pupillary function (HP:0007686)4.61681711
9Orthostatic hypotension (HP:0001278)4.49074346
10Intestinal atresia (HP:0011100)4.30971011
11Hypoventilation (HP:0002791)4.15611392
12Potter facies (HP:0002009)4.05336366
13Facial shape deformation (HP:0011334)4.05336366
14Esophageal atresia (HP:0002032)3.80113402
15Hypokinesia (HP:0002375)3.69837018
16Cerebral hemorrhage (HP:0001342)3.61972046
17Progressive cerebellar ataxia (HP:0002073)3.60555022
18Cortical dysplasia (HP:0002539)3.58092710
19Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.57383435
20Focal seizures (HP:0007359)3.51529922
21Hypercortisolism (HP:0001578)3.47368643
22Limb hypertonia (HP:0002509)3.46985017
23Abnormal autonomic nervous system physiology (HP:0012332)3.46970240
24Abnormality of calcium-phosphate metabolism (HP:0100530)3.23475240
25Oligodactyly (hands) (HP:0001180)3.20886313
26Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.16385454
27Cerebral inclusion bodies (HP:0100314)3.13366236
28Abnormality of the parathyroid morphology (HP:0011766)3.12767004
29Delayed gross motor development (HP:0002194)3.10119445
30Focal motor seizures (HP:0011153)3.09799352
31Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.08568429
32Neoplasm of the peripheral nervous system (HP:0100007)3.08059022
33Morphological abnormality of the pyramidal tract (HP:0002062)3.07417110
34Acute necrotizing encephalopathy (HP:0006965)3.07209329
35Agitation (HP:0000713)3.05890245
36Supernumerary spleens (HP:0009799)3.03197237
37Amblyopia (HP:0000646)3.00593858
38Muscular hypotonia of the trunk (HP:0008936)2.93275191
39Mitochondrial inheritance (HP:0001427)2.91763091
40Abnormality of the phalanges of the 2nd finger (HP:0009541)2.85985311
41Hypotension (HP:0002615)2.85328114
42Anxiety (HP:0000739)2.80518342
43Diminished movement (HP:0002374)2.79325165
44Gastrointestinal atresia (HP:0002589)2.79025484
45Exotropia (HP:0000577)2.77045325
46Abnormality of the phalanges of the 5th finger (HP:0004213)2.76914088
47Oligodactyly (HP:0012165)2.75860366
48Abnormal mitochondria in muscle tissue (HP:0008316)2.75504461
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.73207021
50Progressive macrocephaly (HP:0004481)2.67903620
51Birth length less than 3rd percentile (HP:0003561)2.65959216
52Postural tremor (HP:0002174)2.62492637
53Abnormal number of erythroid precursors (HP:0012131)2.60148169
54Poor suck (HP:0002033)2.56175241
55Delusions (HP:0000746)2.55970189
56Rigidity (HP:0002063)2.55449390
57Short middle phalanx of the 5th finger (HP:0004220)2.53566593
58Generalized tonic-clonic seizures (HP:0002069)2.53216510
59Emotional lability (HP:0000712)2.52966213
60Thyroid carcinoma (HP:0002890)2.46986197
61Retinal dysplasia (HP:0007973)2.46461601
62Abnormality of the labia minora (HP:0012880)2.46079685
63Dyskinesia (HP:0100660)2.45967565
64Increased hepatocellular lipid droplets (HP:0006565)2.43086213
65Hyperthyroidism (HP:0000836)2.40119528
66Long nose (HP:0003189)2.38396686
67Atonic seizures (HP:0010819)2.34527418
68Neuroblastic tumors (HP:0004376)2.34119622
69Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.34119622
70Neuroblastoma (HP:0003006)2.34119622
71Primitive neuroectodermal tumor (HP:0030065)2.34119622
72Torticollis (HP:0000473)2.31650410
73Acute encephalopathy (HP:0006846)2.31337342
74Abnormality of cells of the erythroid lineage (HP:0012130)2.28853875
75Hyperparathyroidism (HP:0000843)2.28682979
76Gait imbalance (HP:0002141)2.28302202
77Increased CSF lactate (HP:0002490)2.27595466
78Bradykinesia (HP:0002067)2.25314921
79Aplasia/Hypoplasia of the sternum (HP:0006714)2.23665901
80Ankle clonus (HP:0011448)2.22674456
81Supranuclear gaze palsy (HP:0000605)2.21578499
82Genital tract atresia (HP:0001827)2.21025482
83Abnormal lung lobation (HP:0002101)2.20784325
84Megalencephaly (HP:0001355)2.19807312
85Craniofacial dystonia (HP:0012179)2.19355221
86Reticulocytosis (HP:0001923)2.17055193
87Hepatocellular necrosis (HP:0001404)2.16073408
88Absence seizures (HP:0002121)2.15454272
89Split foot (HP:0001839)2.14732421
90Progressive inability to walk (HP:0002505)2.14125715
91Polyphagia (HP:0002591)2.13298794
92Depression (HP:0000716)2.12349237
93Nephrogenic diabetes insipidus (HP:0009806)2.12339190
94Bicornuate uterus (HP:0000813)2.12270957
95Nephronophthisis (HP:0000090)2.10058518
96Short palpebral fissure (HP:0012745)2.08584461
97Neonatal hypoglycemia (HP:0001998)2.08406909
98Aplasia/Hypoplasia of the spleen (HP:0010451)2.07905596
99Focal dystonia (HP:0004373)2.06759805
100Abnormality of the duodenum (HP:0002246)2.06397811
101Myoclonus (HP:0001336)2.05919498
102Vaginal atresia (HP:0000148)2.05730609
103Lipid accumulation in hepatocytes (HP:0006561)2.05313444
104Gastroesophageal reflux (HP:0002020)2.05064383
105Partial agenesis of the corpus callosum (HP:0001338)2.04526451
106Depressed nasal tip (HP:0000437)2.04268971
107Volvulus (HP:0002580)2.02901010
108Action tremor (HP:0002345)2.01711215
109Limb dystonia (HP:0002451)13.4233102
110Lissencephaly (HP:0001339)1.99803694
111Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.99444734
112Myotonia (HP:0002486)1.98570184
113Congenital primary aphakia (HP:0007707)1.97536933
114Specific learning disability (HP:0001328)1.94024465
115Abnormality of the corticospinal tract (HP:0002492)1.91624023
116Amyotrophic lateral sclerosis (HP:0007354)1.90133240
117Dialeptic seizures (HP:0011146)1.90056818
118Medial flaring of the eyebrow (HP:0010747)1.88587677
119Asplenia (HP:0001746)1.86570403
120Renal Fanconi syndrome (HP:0001994)1.85462561
121Fetal akinesia sequence (HP:0001989)1.85245882
122Horseshoe kidney (HP:0000085)1.85172391
123Goiter (HP:0000853)1.84965844
124Preaxial hand polydactyly (HP:0001177)1.84678332
125Abnormality of the 4th metacarpal (HP:0010012)1.84310631
126Truncal ataxia (HP:0002078)1.84137795
127Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80068371
128Abnormality of the vocal cords (HP:0008777)1.80039069
129Annular pancreas (HP:0001734)1.78345977
130Medulloblastoma (HP:0002885)1.78006055
131Colon cancer (HP:0003003)1.77083843
132Optic disc pallor (HP:0000543)1.76847099
133Drooling (HP:0002307)1.76490104
134Abnormality of reticulocytes (HP:0004312)1.76137736
135Protruding tongue (HP:0010808)1.74402788
136Neurofibrillary tangles (HP:0002185)1.74048747
137Increased nuchal translucency (HP:0010880)1.73596673
138Febrile seizures (HP:0002373)1.73336251
139Abnormality of the lower motor neuron (HP:0002366)1.73035500
140True hermaphroditism (HP:0010459)1.70806568
141Patellar aplasia (HP:0006443)1.70039316
142Abnormality of the antihelix (HP:0009738)1.69846282
143Polymicrogyria (HP:0002126)1.69786811
144Abnormality of the 2nd finger (HP:0004100)1.69743891
145Rapidly progressive (HP:0003678)1.69659968
146Abnormality of pain sensation (HP:0010832)1.69657260
147Impaired pain sensation (HP:0007328)1.69657260
148Dysautonomia (HP:0002459)1.69372417
149Epileptic encephalopathy (HP:0200134)1.68970363
150Psychosis (HP:0000709)1.68737387
151Microvesicular hepatic steatosis (HP:0001414)1.68724569
152Sclerocornea (HP:0000647)1.68200374
153Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.67991318
154Autoamputation (HP:0001218)1.67531367
155Adrenal overactivity (HP:0002717)1.67389994
156Mask-like facies (HP:0000298)1.66582944
157Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.66350313
158Peripheral hypomyelination (HP:0007182)1.65122750
159Choreoathetosis (HP:0001266)1.64050366
160Cerebellar dysplasia (HP:0007033)1.63688672
161Poor coordination (HP:0002370)1.63149880
162Papilledema (HP:0001085)1.62880605
163Anophthalmia (HP:0000528)1.62511429
164Termporal pattern (HP:0011008)1.62346971
165Triphalangeal thumb (HP:0001199)1.61527831
166Anencephaly (HP:0002323)1.60164883
167Ulnar claw (HP:0001178)1.58564924
168Cutaneous finger syndactyly (HP:0010554)1.57966213
169Chorioretinal atrophy (HP:0000533)1.57505356
170Hyperglycinemia (HP:0002154)1.53481746
171Aplasia/Hypoplasia of the earlobes (HP:0009906)1.53006037
172Aplasia/Hypoplasia of the patella (HP:0006498)1.52803849
173Renal hypoplasia (HP:0000089)1.52745227
174Hemiparesis (HP:0001269)1.52101633
175Aganglionic megacolon (HP:0002251)1.51638749
176Heterotopia (HP:0002282)1.51420017
177Neoplasm of the oral cavity (HP:0100649)1.50975660
178Absent radius (HP:0003974)1.50876350
179Growth hormone deficiency (HP:0000824)1.50506715
180Ectopic kidney (HP:0000086)1.50314489
181Excessive salivation (HP:0003781)1.50081583

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK54.72574959
2MAP3K123.93379874
3GRK53.66121451
4CSNK1G33.64885310
5PBK3.46700583
6PNCK3.38053909
7BUB13.36514325
8NTRK13.24383354
9CSNK1G23.17685340
10MAP3K92.96077612
11MAP3K42.77493472
12CSNK1G12.65796719
13WEE12.42315881
14MARK12.40123486
15PLK42.32784967
16NTRK32.29841109
17GRK62.25710924
18MINK12.25221561
19CDC72.24865391
20MAP2K72.22873587
21ARAF2.19368368
22SRPK12.15152139
23GRK72.06070808
24PLK22.00698097
25MAP2K42.00449263
26TTK1.97302222
27NEK21.86260905
28ALK1.75936883
29EIF2AK11.70457048
30NTRK21.68653731
31FGR1.61416346
32PKN11.61086007
33TNIK1.58394276
34MAP4K21.54293312
35DYRK31.51354966
36RET1.50739877
37MKNK21.49500391
38LATS21.46367761
39CCNB11.45296094
40MKNK11.43925729
41CAMK2A1.43464245
42UHMK11.35112463
43CDK31.33976225
44CHEK21.33055440
45CDK151.30821568
46CDK181.30738255
47CASK1.27703084
48ADRBK11.27051275
49NME11.26479704
50CAMK2B1.26101946
51BRSK21.24798930
52BRD41.24370373
53WNK41.23323216
54CDK141.20358153
55MAPK131.19537558
56CDK11A1.18544591
57PLK11.16486562
58ADRBK21.15707852
59CDK51.15352515
60PTK2B1.14061479
61ZAK1.13972271
62STK391.13626849
63RPS6KA41.12528141
64WNK31.06608356
65TSSK61.03335178
66VRK21.02169160
67CAMK2D1.01508409
68CAMK2G0.98576221
69MATK0.96776703
70BRSK10.96189564
71KSR20.94851554
72ATR0.93872648
73FLT30.91799672
74TRIM280.91476243
75NUAK10.91368953
76PRKCG0.90298086
77PIM20.88936672
78SCYL20.87685336
79VRK10.87537936
80STK160.87071312
81CDK80.85279725
82EPHA40.84912011
83LIMK10.84903601
84PHKG10.83807186
85PHKG20.83807186
86NME20.82303801
87PTK20.79869134
88ATM0.79657730
89DYRK1A0.78661492
90BCKDK0.78576265
91MAP3K100.74278673
92BMPR1B0.70787232
93PAK60.67869722
94MAP2K10.66854374
95MYLK0.62912105
96SIK20.60106697
97PAK30.60068904
98PINK10.59610582
99MET0.58847538
100EPHB20.58596981
101AURKA0.58199960
102CHEK10.57748841
103AURKB0.53303341
104CLK10.53171618
105KSR10.53095491
106EIF2AK30.53070158
107WNK10.52297079
108TAF10.51086716
109YES10.49621238
110PLK30.49519617
111AKT30.49400302
112LMTK20.48999935
113RAF10.48320856
114CSNK1E0.48239993
115CDK10.47841704
116PRKDC0.47705233
117TYRO30.47606630
118CDK20.47455207
119CAMK1G0.47027353
120ERBB40.46148571
121MAP3K130.45691231
122DAPK20.45653573
123PRKCE0.45469410
124CDK190.44640771
125DAPK10.44607025
126DYRK20.42425804
127RPS6KA50.41617609
128FES0.39968374
129CSNK2A10.39688981
130CSNK1A1L0.39055592
131PRKACA0.38668297
132CSNK1A10.37806846
133MOS0.36598819
134SYK0.36252814
135OXSR10.35951314
136SGK4940.35756353
137SGK2230.35756353
138EIF2AK20.34455042
139FYN0.33528261
140CDK70.33378445
141ERBB30.32440180
142ROCK20.31922482
143PRKD30.31319726
144STK110.31170849
145BCR0.30589866
146RPS6KA20.28082514
147CSNK1D0.28035063
148PRKCZ0.27196308
149MAP3K20.26934370
150MAPK40.26709142
151PRKCB0.26192674
152CAMKK20.24944365
153BRAF0.24720421
154NEK10.24141315
155IGF1R0.23278094
156PRKACB0.22445978
157PRKACG0.20667416
158CSNK2A20.20320553

Predicted pathways (KEGG)

RankGene SetZ-score
1Cocaine addiction_Homo sapiens_hsa050304.74934405
2Synaptic vesicle cycle_Homo sapiens_hsa047214.06710605
3Parkinsons disease_Homo sapiens_hsa050123.82168222
4Amphetamine addiction_Homo sapiens_hsa050313.54416338
5Oxidative phosphorylation_Homo sapiens_hsa001903.41900850
6Tyrosine metabolism_Homo sapiens_hsa003503.32379218
7Phenylalanine metabolism_Homo sapiens_hsa003603.09499180
8Dopaminergic synapse_Homo sapiens_hsa047282.93173833
9DNA replication_Homo sapiens_hsa030302.82388161
10Serotonergic synapse_Homo sapiens_hsa047262.59060149
11Collecting duct acid secretion_Homo sapiens_hsa049662.53593942
12Fanconi anemia pathway_Homo sapiens_hsa034602.51286664
13Mismatch repair_Homo sapiens_hsa034302.50948120
14Nicotine addiction_Homo sapiens_hsa050332.40984657
15Basal transcription factors_Homo sapiens_hsa030222.35562922
16Base excision repair_Homo sapiens_hsa034102.31850302
17Homologous recombination_Homo sapiens_hsa034402.29495546
18Alzheimers disease_Homo sapiens_hsa050102.28849675
19Cell cycle_Homo sapiens_hsa041102.25526613
20Cholinergic synapse_Homo sapiens_hsa047252.23168267
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94261140
22Vibrio cholerae infection_Homo sapiens_hsa051101.89557468
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89172421
24Non-homologous end-joining_Homo sapiens_hsa034501.88254383
25Nucleotide excision repair_Homo sapiens_hsa034201.85483995
26Huntingtons disease_Homo sapiens_hsa050161.83393389
27RNA polymerase_Homo sapiens_hsa030201.83387591
28Spliceosome_Homo sapiens_hsa030401.79657901
29RNA transport_Homo sapiens_hsa030131.78874834
30Histidine metabolism_Homo sapiens_hsa003401.76403268
31Sulfur relay system_Homo sapiens_hsa041221.71364588
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69891154
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59416630
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54497492
35Cardiac muscle contraction_Homo sapiens_hsa042601.54046653
36Nitrogen metabolism_Homo sapiens_hsa009101.52954621
37Circadian entrainment_Homo sapiens_hsa047131.51837447
38GABAergic synapse_Homo sapiens_hsa047271.51475092
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44427634
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41294733
41Alcoholism_Homo sapiens_hsa050341.40271701
42Long-term depression_Homo sapiens_hsa047301.39682974
43Insulin secretion_Homo sapiens_hsa049111.38713157
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36412818
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35767595
46Gap junction_Homo sapiens_hsa045401.34300309
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33576970
48Long-term potentiation_Homo sapiens_hsa047201.32760072
49Olfactory transduction_Homo sapiens_hsa047401.29952460
50mRNA surveillance pathway_Homo sapiens_hsa030151.29599849
51Selenocompound metabolism_Homo sapiens_hsa004501.29396147
52Glutamatergic synapse_Homo sapiens_hsa047241.28085537
53Salivary secretion_Homo sapiens_hsa049701.22716504
54Renin secretion_Homo sapiens_hsa049241.21391230
55RNA degradation_Homo sapiens_hsa030181.18367386
56Morphine addiction_Homo sapiens_hsa050321.17136970
57Pyrimidine metabolism_Homo sapiens_hsa002401.16812046
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14359201
59Linoleic acid metabolism_Homo sapiens_hsa005911.14256417
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13241083
61Tryptophan metabolism_Homo sapiens_hsa003801.13222329
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12368922
63Taste transduction_Homo sapiens_hsa047421.11525266
64Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06522434
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05906282
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04750314
67Ether lipid metabolism_Homo sapiens_hsa005651.04034103
68Protein export_Homo sapiens_hsa030601.03421587
69Fatty acid metabolism_Homo sapiens_hsa012121.02318906
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01297494
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99421778
72GnRH signaling pathway_Homo sapiens_hsa049120.98311475
73Gastric acid secretion_Homo sapiens_hsa049710.97684266
74Calcium signaling pathway_Homo sapiens_hsa040200.96151124
75Vitamin B6 metabolism_Homo sapiens_hsa007500.95491273
76Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95061991
77One carbon pool by folate_Homo sapiens_hsa006700.94112481
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.92026881
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91985248
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87460993
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84903969
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83970967
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83403727
84Purine metabolism_Homo sapiens_hsa002300.83101108
85Estrogen signaling pathway_Homo sapiens_hsa049150.80957820
86African trypanosomiasis_Homo sapiens_hsa051430.77155926
87Oxytocin signaling pathway_Homo sapiens_hsa049210.75760853
88Proteasome_Homo sapiens_hsa030500.73912144
89Lysine degradation_Homo sapiens_hsa003100.72600234
90Basal cell carcinoma_Homo sapiens_hsa052170.69752407
91Pyruvate metabolism_Homo sapiens_hsa006200.67727519
92Rheumatoid arthritis_Homo sapiens_hsa053230.64820919
93Carbon metabolism_Homo sapiens_hsa012000.63858182
94Melanogenesis_Homo sapiens_hsa049160.63232447
95Phagosome_Homo sapiens_hsa041450.62496383
96Thyroid hormone synthesis_Homo sapiens_hsa049180.62209075
97Biosynthesis of amino acids_Homo sapiens_hsa012300.60501134
98Axon guidance_Homo sapiens_hsa043600.58793052
99Fatty acid biosynthesis_Homo sapiens_hsa000610.58487413
100Fatty acid elongation_Homo sapiens_hsa000620.58417526
101Thyroid cancer_Homo sapiens_hsa052160.57431093
102Dorso-ventral axis formation_Homo sapiens_hsa043200.57020366
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55318425
104MicroRNAs in cancer_Homo sapiens_hsa052060.54431620
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53412618
106Butanoate metabolism_Homo sapiens_hsa006500.52621510
107Pancreatic secretion_Homo sapiens_hsa049720.49285289
108Hedgehog signaling pathway_Homo sapiens_hsa043400.48799165
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.48656898
110Steroid biosynthesis_Homo sapiens_hsa001000.48080830
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45355971
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45152585
113Hippo signaling pathway_Homo sapiens_hsa043900.44028191
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.43740826
115Glucagon signaling pathway_Homo sapiens_hsa049220.42310426
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41455683
117p53 signaling pathway_Homo sapiens_hsa041150.40908629
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39076426
119cAMP signaling pathway_Homo sapiens_hsa040240.37742886
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.36165299
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.35716973
122Oocyte meiosis_Homo sapiens_hsa041140.35114108
123Prion diseases_Homo sapiens_hsa050200.34743737
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34373053
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33924441
126Type II diabetes mellitus_Homo sapiens_hsa049300.32612459
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32029853
128Wnt signaling pathway_Homo sapiens_hsa043100.31714097
129Bile secretion_Homo sapiens_hsa049760.31345783
130Peroxisome_Homo sapiens_hsa041460.31303519
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28731848
132Colorectal cancer_Homo sapiens_hsa052100.28047725
133Phototransduction_Homo sapiens_hsa047440.27862341
134Dilated cardiomyopathy_Homo sapiens_hsa054140.27681734
135ErbB signaling pathway_Homo sapiens_hsa040120.25564046
136Ovarian steroidogenesis_Homo sapiens_hsa049130.25411499
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24499409
138Prolactin signaling pathway_Homo sapiens_hsa049170.24260121
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.22412955
140Arginine and proline metabolism_Homo sapiens_hsa003300.20344313
141Choline metabolism in cancer_Homo sapiens_hsa052310.20277094
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.19409164
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18509894
144Metabolic pathways_Homo sapiens_hsa011000.17909614
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.17766046
146MAPK signaling pathway_Homo sapiens_hsa040100.17359375
147Glioma_Homo sapiens_hsa052140.17007106
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.16670944
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.14588083
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.14279646
151Glycerolipid metabolism_Homo sapiens_hsa005610.13643984
152Propanoate metabolism_Homo sapiens_hsa006400.10831307
153Sulfur metabolism_Homo sapiens_hsa009200.10776308
154Ribosome_Homo sapiens_hsa030100.09111294
155Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08126035

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