SLC10A5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.44255818
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.44255818
3L-phenylalanine metabolic process (GO:0006558)7.08829686
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.08829686
5aromatic amino acid family catabolic process (GO:0009074)6.80999506
6indole-containing compound catabolic process (GO:0042436)6.26203205
7indolalkylamine catabolic process (GO:0046218)6.26203205
8tryptophan catabolic process (GO:0006569)6.26203205
9kynurenine metabolic process (GO:0070189)6.07271712
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.00419068
11bile acid biosynthetic process (GO:0006699)5.90135260
12tryptophan metabolic process (GO:0006568)5.89315110
13glyoxylate metabolic process (GO:0046487)5.72464011
14urea metabolic process (GO:0019627)5.64631181
15urea cycle (GO:0000050)5.64631181
16alpha-linolenic acid metabolic process (GO:0036109)5.50931004
17cysteine metabolic process (GO:0006534)5.46337825
18sulfur amino acid catabolic process (GO:0000098)5.32239978
19complement activation, alternative pathway (GO:0006957)5.25093786
20negative regulation of fibrinolysis (GO:0051918)5.24613599
21high-density lipoprotein particle remodeling (GO:0034375)5.22723666
22nitrogen cycle metabolic process (GO:0071941)5.18422311
23regulation of protein activation cascade (GO:2000257)5.17707217
24peptidyl-glutamic acid carboxylation (GO:0017187)5.13074058
25protein carboxylation (GO:0018214)5.13074058
26bile acid metabolic process (GO:0008206)5.09046713
27homocysteine metabolic process (GO:0050667)5.07163554
28regulation of fibrinolysis (GO:0051917)5.06953067
29serine family amino acid catabolic process (GO:0009071)5.05675956
30fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.02218406
31aromatic amino acid family metabolic process (GO:0009072)4.93217640
32regulation of complement activation (GO:0030449)4.85163460
33lysine catabolic process (GO:0006554)4.82195900
34lysine metabolic process (GO:0006553)4.82195900
35negative regulation of cell aging (GO:0090344)4.80987819
36amino-acid betaine metabolic process (GO:0006577)4.67075889
37tyrosine metabolic process (GO:0006570)4.64595979
38regulation of triglyceride catabolic process (GO:0010896)4.64435576
39alpha-amino acid catabolic process (GO:1901606)4.63312147
40reverse cholesterol transport (GO:0043691)4.60623129
41regulation of cholesterol esterification (GO:0010872)4.56965133
42plasma lipoprotein particle remodeling (GO:0034369)4.54914042
43protein-lipid complex remodeling (GO:0034368)4.54914042
44macromolecular complex remodeling (GO:0034367)4.54914042
45triglyceride homeostasis (GO:0070328)4.46975454
46acylglycerol homeostasis (GO:0055090)4.46975454
47nucleotide transmembrane transport (GO:1901679)4.46606240
48negative regulation of sterol transport (GO:0032372)4.44066880
49negative regulation of cholesterol transport (GO:0032375)4.44066880
50indolalkylamine metabolic process (GO:0006586)4.43189045
51cellular response to ATP (GO:0071318)4.40005143
52cellular ketone body metabolic process (GO:0046950)4.38348694
53cellular glucuronidation (GO:0052695)4.36818128
54phospholipid efflux (GO:0033700)4.35101675
55cellular biogenic amine catabolic process (GO:0042402)4.34037433
56amine catabolic process (GO:0009310)4.34037433
57glycine metabolic process (GO:0006544)4.32321802
58mitotic cell cycle arrest (GO:0071850)4.31859852
59coenzyme catabolic process (GO:0009109)4.30986330
60cellular amino acid catabolic process (GO:0009063)4.28977078
61drug catabolic process (GO:0042737)4.28895758
62* bile acid and bile salt transport (GO:0015721)4.27653648
63transepithelial transport (GO:0070633)4.26459269
64glutamate metabolic process (GO:0006536)4.24294187
65imidazole-containing compound metabolic process (GO:0052803)4.21381207
66regulation of skeletal muscle contraction (GO:0014819)4.20321127
67serine family amino acid metabolic process (GO:0009069)4.19258240
68benzene-containing compound metabolic process (GO:0042537)4.16025664
69ethanol oxidation (GO:0006069)4.15488434
70plasma lipoprotein particle clearance (GO:0034381)4.14437874
71meiotic chromosome segregation (GO:0045132)4.12442812
72cellular modified amino acid catabolic process (GO:0042219)4.12229289
73cholesterol efflux (GO:0033344)4.11409965
74serine family amino acid biosynthetic process (GO:0009070)4.01641135
75dicarboxylic acid biosynthetic process (GO:0043650)4.00375588
76regulation of bile acid biosynthetic process (GO:0070857)3.96462427
77low-density lipoprotein particle remodeling (GO:0034374)3.91341099
78plasma lipoprotein particle assembly (GO:0034377)3.90759570
79righting reflex (GO:0060013)3.90157409
80glucuronate metabolic process (GO:0019585)3.90123463
81uronic acid metabolic process (GO:0006063)3.90123463
82arginine metabolic process (GO:0006525)3.89900617
83aldehyde catabolic process (GO:0046185)3.84359562
84DNA strand renaturation (GO:0000733)3.83167813
85short-chain fatty acid metabolic process (GO:0046459)3.80420715
86phospholipid homeostasis (GO:0055091)3.78945445
87ketone body metabolic process (GO:1902224)3.78871124
88protein localization to cilium (GO:0061512)3.78864061
89very-low-density lipoprotein particle assembly (GO:0034379)3.78591462
90fibrinolysis (GO:0042730)3.78523920
91drug transmembrane transport (GO:0006855)3.78402812
92carboxylic acid catabolic process (GO:0046395)3.76530624
93organic acid catabolic process (GO:0016054)3.76530624
94cholesterol homeostasis (GO:0042632)3.76024881
95acetyl-CoA metabolic process (GO:0006084)3.74892406
96regulation of cholesterol homeostasis (GO:2000188)3.73568402
97urate metabolic process (GO:0046415)3.72721797
98exogenous drug catabolic process (GO:0042738)3.71297078
99sterol homeostasis (GO:0055092)3.70936879
100cofactor catabolic process (GO:0051187)3.66079413
101L-methionine salvage (GO:0071267)3.64044078
102L-methionine biosynthetic process (GO:0071265)3.64044078
103amino acid salvage (GO:0043102)3.64044078
104intestinal cholesterol absorption (GO:0030299)3.63984191
105blood coagulation, intrinsic pathway (GO:0007597)3.63713454
106positive regulation of lipid catabolic process (GO:0050996)3.63513055
107positive regulation of lipoprotein lipase activity (GO:0051006)3.63469353
108positive regulation of triglyceride lipase activity (GO:0061365)3.63469353
109complement activation, classical pathway (GO:0006958)3.63049809
110flavonoid metabolic process (GO:0009812)3.61137543
111complement activation (GO:0006956)3.60811254
112protein activation cascade (GO:0072376)3.58008826
113cytolysis (GO:0019835)3.57542402
114L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.50849477
115estrogen biosynthetic process (GO:0006703)3.49854027
116oxidative demethylation (GO:0070989)3.33742614
117biotin metabolic process (GO:0006768)3.31020062
118purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.30280553
1193-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.30280553
120behavioral response to nicotine (GO:0035095)3.12263057
121S-adenosylmethionine metabolic process (GO:0046500)3.08693222
122methionine biosynthetic process (GO:0009086)3.07550873
123GDP-mannose metabolic process (GO:0019673)2.99390934
124purine ribonucleotide transport (GO:0015868)2.97513593
125estrogen metabolic process (GO:0008210)2.92437932
126detection of light stimulus involved in sensory perception (GO:0050962)2.89829994
127detection of light stimulus involved in visual perception (GO:0050908)2.89829994
128water-soluble vitamin biosynthetic process (GO:0042364)2.88085575
129sphingomyelin metabolic process (GO:0006684)2.86958622
130magnesium ion transport (GO:0015693)2.86415172
131rRNA methylation (GO:0031167)2.86059038
132alkaloid metabolic process (GO:0009820)2.83586705
133keratinocyte development (GO:0003334)2.82436220
134regulation of hexokinase activity (GO:1903299)2.78718568
135regulation of glucokinase activity (GO:0033131)2.78718568
136peptidyl-glutamic acid modification (GO:0018200)2.78328717
137nucleoside transmembrane transport (GO:1901642)2.77189029
138negative regulation of digestive system process (GO:0060457)2.75483346
139phosphate ion transmembrane transport (GO:0035435)2.74346776
140phenylpropanoid metabolic process (GO:0009698)2.73382992
141protein import into peroxisome matrix (GO:0016558)2.71126010
142respiratory chain complex IV assembly (GO:0008535)2.69720771
143nucleotide-sugar biosynthetic process (GO:0009226)2.69426827
144positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.69050596
145oligosaccharide catabolic process (GO:0009313)2.65131889
146epoxygenase P450 pathway (GO:0019373)2.64025141
147ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.64019390
148nucleoside bisphosphate biosynthetic process (GO:0033866)2.64019390
149purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.64019390
150heme transport (GO:0015886)2.61622489
151branched-chain amino acid catabolic process (GO:0009083)2.55903792
152lens fiber cell differentiation (GO:0070306)2.55023405
153cilium or flagellum-dependent cell motility (GO:0001539)2.54625275
154omega-hydroxylase P450 pathway (GO:0097267)2.50530745
155fatty acid homeostasis (GO:0055089)2.46974193
156bundle of His cell to Purkinje myocyte communication (GO:0086069)2.46378166
157peristalsis (GO:0030432)2.46067955
158sphingoid metabolic process (GO:0046519)2.45499930
159phosphatidylcholine biosynthetic process (GO:0006656)2.43373873
160aspartate family amino acid biosynthetic process (GO:0009067)2.42224640
161methionine metabolic process (GO:0006555)2.42089376
162purine nucleoside bisphosphate metabolic process (GO:0034032)2.40679047

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.25188481
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.10645660
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.86942427
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.48746839
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.17512947
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.87555489
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.58721748
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04441921
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.85048625
10SALL1_21062744_ChIP-ChIP_HESCs_Human3.64013886
11IGF1R_20145208_ChIP-Seq_DFB_Human2.71429602
12VDR_22108803_ChIP-Seq_LS180_Human2.69308506
13FUS_26573619_Chip-Seq_HEK293_Human2.45295539
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37595734
15EWS_26573619_Chip-Seq_HEK293_Human2.35156259
16* TAF15_26573619_Chip-Seq_HEK293_Human2.26641080
17HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10773392
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05998392
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6292309
20AR_21909140_ChIP-Seq_LNCAP_Human1.91055877
21AR_21572438_ChIP-Seq_LNCaP_Human1.88648946
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85128471
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84511489
24PKCTHETA_26484144_Chip-Seq_BREAST_Human1.81028789
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79510565
26ZNF274_21170338_ChIP-Seq_K562_Hela1.77925687
27ER_23166858_ChIP-Seq_MCF-7_Human1.77323165
28XRN2_22483619_ChIP-Seq_HELA_Human1.70104741
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.67876695
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65363519
31TP53_22573176_ChIP-Seq_HFKS_Human1.61109777
32HTT_18923047_ChIP-ChIP_STHdh_Human1.52564679
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52211151
34DCP1A_22483619_ChIP-Seq_HELA_Human1.51732100
35CLOCK_20551151_ChIP-Seq_293T_Human1.51399837
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51076238
37HNF4A_19822575_ChIP-Seq_HepG2_Human1.48575229
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43853244
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40478452
40* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39415777
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38731383
42GATA1_22025678_ChIP-Seq_K562_Human1.38367201
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32255571
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31412435
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31122893
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29736701
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28365342
48RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25171503
49TP53_22127205_ChIP-Seq_IMR90_Human1.23026237
50FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22141520
51P68_20966046_ChIP-Seq_HELA_Human1.21757512
52ERA_21632823_ChIP-Seq_H3396_Human1.19965826
53E2F1_20622854_ChIP-Seq_HELA_Human1.17735424
54SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17272813
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13543470
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13095757
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11559275
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09535430
59NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.09096002
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09052707
61CBP_20019798_ChIP-Seq_JUKART_Human1.08099241
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08099241
63VDR_23849224_ChIP-Seq_CD4+_Human1.07404193
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07216177
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07098672
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06696258
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04980845
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03403245
69CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02528739
70ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02525445
71CHD1_26751641_Chip-Seq_LNCaP_Human1.02074107
72MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01859424
73GATA4_25053715_ChIP-Seq_YYC3_Human1.01659505
74GABP_17652178_ChIP-ChIP_JURKAT_Human1.01556413
75FOXP1_21924763_ChIP-Seq_HESCs_Human1.00864415
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00795171
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.00692589
78BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99931675
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99808979
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99739560
81MYC_19829295_ChIP-Seq_ESCs_Human0.99494654
82GBX2_23144817_ChIP-Seq_PC3_Human0.95929183
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93606048
84KDM5A_27292631_Chip-Seq_BREAST_Human0.93571729
85STAT3_23295773_ChIP-Seq_U87_Human0.92552625
86ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92122586
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91987283
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.90743822
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.87700693
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86325808
91CDX2_20551321_ChIP-Seq_CACO-2_Human0.85871382
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85108896
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85107055
94OCT4_20526341_ChIP-Seq_ESCs_Human0.84420405
95IRF8_22096565_ChIP-ChIP_GC-B_Human0.83892325
96CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83006585
97KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82934400
98ETS1_20019798_ChIP-Seq_JURKAT_Human0.82917150
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82585321
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82483253
101AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80465947
102RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80202975
103AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80072471
104ESR2_21235772_ChIP-Seq_MCF-7_Human0.79336168
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75361616
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74906017
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.73625309
108NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72013819
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72013819
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71650569
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71234366
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.69750147
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.69175768
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68147909
115ESR1_21235772_ChIP-Seq_MCF-7_Human0.67824414
116ZNF263_19887448_ChIP-Seq_K562_Human0.66060703
117FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.63390276
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61924831
119BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61100380
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60003141
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.59846700
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.58706514
123CEBPB_22108803_ChIP-Seq_LS180_Human0.58120801
124RARB_24833708_ChIP-Seq_LIVER_Mouse0.58114980
125EGR1_19032775_ChIP-ChIP_M12_Human0.57798184
126GATA6_25053715_ChIP-Seq_YYC3_Human0.57597904
127STAT1_17558387_ChIP-Seq_HELA_Human0.56254286
128PPAR_26484153_Chip-Seq_NCI-H1993_Human0.55928100
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55482708
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.54117975
131AR_20517297_ChIP-Seq_VCAP_Human0.54000963
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.53600928
133MYC_19915707_ChIP-ChIP_AK7_Human0.53200431
134ESET_19884257_ChIP-Seq_ESCs_Mouse0.52471140
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.52418674
136PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50626557
137CBP_21632823_ChIP-Seq_H3396_Human0.50266695
138SOX2_20726797_ChIP-Seq_SW620_Human0.50153718
139CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.49867525
140FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.48970621
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.48591789
142GATA2_19941826_ChIP-Seq_K562_Human0.48057152
143BCAT_22108803_ChIP-Seq_LS180_Human0.47630028
144PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46624551
145CDX2_22108803_ChIP-Seq_LS180_Human0.46429733
146LXR_22292898_ChIP-Seq_THP-1_Human0.46173013
147STAT3_1855785_ChIP-Seq_MESCs_Mouse0.44584977
148SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.44337506
149P53_21459846_ChIP-Seq_SAOS-2_Human0.44022347
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44016066
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.43565636
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43504620
153GATA1_19941826_ChIP-Seq_K562_Human0.42454336
154EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.42344392
155TAF2_19829295_ChIP-Seq_ESCs_Human0.42326713
156GATA1_19941827_ChIP-Seq_MEL_Mouse0.41622492
157GATA3_24758297_ChIP-Seq_MCF-7_Human0.40961943
158ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.39208332
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.37458681
160PIAS1_25552417_ChIP-Seq_VCAP_Human0.36481432
161NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.36214756
162FOXH1_21741376_ChIP-Seq_EPCs_Human0.36153959
163OCT4_21477851_ChIP-Seq_ESCs_Mouse0.35498766
164ERG_21242973_ChIP-ChIP_JURKAT_Human0.35430852
165NCOR_22424771_ChIP-Seq_293T_Human0.35302770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.17161753
2MP0005360_urolithiasis7.88963548
3MP0005085_abnormal_gallbladder_physiolo6.44983471
4MP0005365_abnormal_bile_salt6.11637314
5MP0008875_abnormal_xenobiotic_pharmacok5.14568322
6MP0003806_abnormal_nucleotide_metabolis4.07616158
7MP0003252_abnormal_bile_duct4.04294612
8MP0001986_abnormal_taste_sensitivity3.52044806
9MP0010329_abnormal_lipoprotein_level3.51482282
10MP0005083_abnormal_biliary_tract3.00326054
11MP0009840_abnormal_foam_cell2.93999246
12MP0005171_absent_coat_pigmentation2.89654039
13MP0000516_abnormal_urinary_system2.89383033
14MP0005367_renal/urinary_system_phenotyp2.89383033
15MP0001666_abnormal_nutrient_absorption2.85847761
16MP0005332_abnormal_amino_acid2.82880843
17MP0003195_calcinosis2.80446285
18MP0005423_abnormal_somatic_nervous2.77403812
19MP0005174_abnormal_tail_pigmentation2.71589972
20MP0003136_yellow_coat_color2.68509679
21MP0004019_abnormal_vitamin_homeostasis2.34038603
22MP0001188_hyperpigmentation2.21570428
23MP0000609_abnormal_liver_physiology2.11457542
24MP0003191_abnormal_cellular_cholesterol2.10867655
25MP0002118_abnormal_lipid_homeostasis2.05775788
26MP0003283_abnormal_digestive_organ2.04892107
27MP0002009_preneoplasia2.03879725
28MP0002138_abnormal_hepatobiliary_system2.03036012
29MP0003868_abnormal_feces_composition1.97800716
30MP0002909_abnormal_adrenal_gland1.89409491
31MP0001968_abnormal_touch/_nociception1.85460380
32MP0005551_abnormal_eye_electrophysiolog1.84397740
33MP0005319_abnormal_enzyme/_coenzyme1.82350359
34MP0008057_abnormal_DNA_replication1.81269867
35MP0003315_abnormal_perineum_morphology1.75226487
36MP0002736_abnormal_nociception_after1.75027433
37MP0003941_abnormal_skin_development1.69362486
38MP0009697_abnormal_copulation1.63334432
39MP0001764_abnormal_homeostasis1.62734140
40MP0004147_increased_porphyrin_level1.55848084
41MP0002735_abnormal_chemical_nociception1.55385261
42MP0005584_abnormal_enzyme/coenzyme_acti1.54475549
43MP0002234_abnormal_pharynx_morphology1.48959420
44MP0006276_abnormal_autonomic_nervous1.38781846
45MP0002638_abnormal_pupillary_reflex1.38187317
46MP0009643_abnormal_urine_homeostasis1.37452305
47MP0005451_abnormal_body_composition1.35266919
48MP0003943_abnormal_hepatobiliary_system1.21479010
49MP0003186_abnormal_redox_activity1.21244199
50MP0000566_synostosis1.21223489
51MP0003011_delayed_dark_adaptation1.18942330
52MP0000537_abnormal_urethra_morphology1.18576708
53MP0010386_abnormal_urinary_bladder1.14312460
54MP0000598_abnormal_liver_morphology1.13835558
55MP0005647_abnormal_sex_gland1.12407793
56MP0003656_abnormal_erythrocyte_physiolo1.12390194
57MP0000013_abnormal_adipose_tissue1.09908373
58MP0003705_abnormal_hypodermis_morpholog1.07829110
59MP0002254_reproductive_system_inflammat1.07626617
60MP0009764_decreased_sensitivity_to1.06807576
61MP0001919_abnormal_reproductive_system1.06202383
62MP0002160_abnormal_reproductive_system1.05729038
63MP0005636_abnormal_mineral_homeostasis1.04644257
64MP0005410_abnormal_fertilization1.01876353
65MP0003879_abnormal_hair_cell0.99558525
66MP0005187_abnormal_penis_morphology0.97158354
67MP0005084_abnormal_gallbladder_morpholo0.96776511
68MP0001664_abnormal_digestion0.95528832
69MP0000604_amyloidosis0.95371167
70MP0009763_increased_sensitivity_to0.95326568
71MP0005645_abnormal_hypothalamus_physiol0.91447521
72MP0005408_hypopigmentation0.87338913
73MP0005646_abnormal_pituitary_gland0.86991110
74MP0008469_abnormal_protein_level0.86283713
75MP0005386_behavior/neurological_phenoty0.86247193
76MP0004924_abnormal_behavior0.86247193
77MP0009642_abnormal_blood_homeostasis0.86176989
78MP0002876_abnormal_thyroid_physiology0.86017417
79MP0010368_abnormal_lymphatic_system0.85923139
80MP0004145_abnormal_muscle_electrophysio0.84394544
81MP0004215_abnormal_myocardial_fiber0.82360587
82MP0001944_abnormal_pancreas_morphology0.81690007
83MP0005220_abnormal_exocrine_pancreas0.79886369
84MP0002697_abnormal_eye_size0.78905453
85MP0003693_abnormal_embryo_hatching0.78841730
86MP0000631_abnormal_neuroendocrine_gland0.78807573
87MP0009765_abnormal_xenobiotic_induced0.78021206
88MP0009046_muscle_twitch0.77047949
89MP0006036_abnormal_mitochondrial_physio0.76929907
90MP0005376_homeostasis/metabolism_phenot0.76038818
91MP0003111_abnormal_nucleus_morphology0.76026633
92MP0002078_abnormal_glucose_homeostasis0.75640845
93MP0005409_darkened_coat_color0.75398146
94MP0005670_abnormal_white_adipose0.74534253
95MP0000613_abnormal_salivary_gland0.74294282
96MP0001905_abnormal_dopamine_level0.73931954
97MP0001756_abnormal_urination0.70786656
98MP0002090_abnormal_vision0.70394072
99MP0001502_abnormal_circadian_rhythm0.69550502
100MP0003183_abnormal_peptide_metabolism0.69527197
101MP0002971_abnormal_brown_adipose0.66918540
102MP0003119_abnormal_digestive_system0.66901775
103MP0005334_abnormal_fat_pad0.66645656
104MP0005535_abnormal_body_temperature0.65965173
105MP0000427_abnormal_hair_cycle0.65565058
106MP0001324_abnormal_eye_pigmentation0.64692418
107MP0001661_extended_life_span0.63692748
108MP0005266_abnormal_metabolism0.63040889
109MP0004130_abnormal_muscle_cell0.61791877
110MP0001346_abnormal_lacrimal_gland0.61781900
111MP0001486_abnormal_startle_reflex0.61492792
112MP0002136_abnormal_kidney_physiology0.59378548
113MP0009053_abnormal_anal_canal0.59144429
114MP0003880_abnormal_central_pattern0.58703102
115MP0002928_abnormal_bile_duct0.58229841
116MP0004197_abnormal_fetal_growth/weight/0.57904969
117MP0005448_abnormal_energy_balance0.57788898
118MP0003890_abnormal_embryonic-extraembry0.57391691
119MP0003690_abnormal_glial_cell0.56667030
120MP0002822_catalepsy0.55208617
121MP0005501_abnormal_skin_physiology0.54594934
122MP0000747_muscle_weakness0.54120338
123MP0002069_abnormal_eating/drinking_beha0.54021412
124MP0000462_abnormal_digestive_system0.53838729
125MP0006035_abnormal_mitochondrial_morpho0.53699095
126MP0000639_abnormal_adrenal_gland0.51693023
127MP0003329_amyloid_beta_deposits0.51295804
128MP0004043_abnormal_pH_regulation0.51045695
129MP0003638_abnormal_response/metabolism_0.48654515
130MP0005464_abnormal_platelet_physiology0.48083702
131MP0005395_other_phenotype0.47822358
132MP0010234_abnormal_vibrissa_follicle0.47318643
133MP0004264_abnormal_extraembryonic_tissu0.46419964
134MP0003718_maternal_effect0.46416246
135MP0004782_abnormal_surfactant_physiolog0.45996505
136MP0003724_increased_susceptibility_to0.45276149
137MP0009384_cardiac_valve_regurgitation0.43954163
138MP0003953_abnormal_hormone_level0.41557461
139MP0002796_impaired_skin_barrier0.41526741
140MP0008873_increased_physiological_sensi0.40619658
141MP0008874_decreased_physiological_sensi0.40127579
142MP0005166_decreased_susceptibility_to0.39936535
143MP0005248_abnormal_Harderian_gland0.39236743
144MP0000230_abnormal_systemic_arterial0.38579594
145MP0000579_abnormal_nail_morphology0.37591811
146MP0008872_abnormal_physiological_respon0.37515543
147MP0003436_decreased_susceptibility_to0.37384885
148MP0001765_abnormal_ion_homeostasis0.37239774
149MP0004381_abnormal_hair_follicle0.36257385
150MP0005666_abnormal_adipose_tissue0.36056886
151MP0003075_altered_response_to0.34233147
152MP0002168_other_aberrant_phenotype0.32760887
153MP0005167_abnormal_blood-brain_barrier0.32683491
154MP0001853_heart_inflammation0.32193989
155MP0009672_abnormal_birth_weight0.31962537
156MP0009115_abnormal_fat_cell0.30779779
157MP0000538_abnormal_urinary_bladder0.29668412
158MP0002837_dystrophic_cardiac_calcinosis0.29209105
159MP0001881_abnormal_mammary_gland0.28921992
160MP0001845_abnormal_inflammatory_respons0.28750337
161MP0000249_abnormal_blood_vessel0.28465310
162MP0006082_CNS_inflammation0.27096713
163MP0003300_gastrointestinal_ulcer0.26526964

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.39472030
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.08198520
3Deep venous thrombosis (HP:0002625)7.05769908
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.52620989
5Hypobetalipoproteinemia (HP:0003563)6.39565872
6Prolonged partial thromboplastin time (HP:0003645)6.32161715
7Xanthomatosis (HP:0000991)6.18564914
8Complement deficiency (HP:0004431)5.23457803
9Testicular atrophy (HP:0000029)5.20439912
10Hyperlipoproteinemia (HP:0010980)5.10802616
11Attenuation of retinal blood vessels (HP:0007843)4.82334566
12Hypolipoproteinemia (HP:0010981)4.67420540
13Joint hemorrhage (HP:0005261)4.61757203
14Hyperammonemia (HP:0001987)4.61717977
15Epidermoid cyst (HP:0200040)4.58883611
16Hyperglycinemia (HP:0002154)4.57223796
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.56192076
18Fat malabsorption (HP:0002630)4.38766623
19Abnormality of the common coagulation pathway (HP:0010990)4.30040499
20Ketosis (HP:0001946)4.29270820
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26180673
22Abnormality of sulfur amino acid metabolism (HP:0004339)4.23710178
23Hyperglycinuria (HP:0003108)4.21551295
24Conjugated hyperbilirubinemia (HP:0002908)4.19719849
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.16407685
26Abnormality of serine family amino acid metabolism (HP:0010894)4.16059907
27Abnormality of glycine metabolism (HP:0010895)4.16059907
28Abnormality of methionine metabolism (HP:0010901)4.01820807
29Hypoalphalipoproteinemia (HP:0003233)3.90730952
30Abnormality of complement system (HP:0005339)3.78302659
31Hypoglycemic coma (HP:0001325)3.75996329
32Abnormality of pyrimidine metabolism (HP:0004353)3.72380009
33Rectovaginal fistula (HP:0000143)3.69577054
34Rectal fistula (HP:0100590)3.69577054
35Dyschromatopsia (HP:0007641)3.67462640
36Abnormality of the intrinsic pathway (HP:0010989)3.67288104
37Hypercholesterolemia (HP:0003124)3.62080844
38Rib fusion (HP:0000902)3.57320565
39Vaginal fistula (HP:0004320)3.54614901
40Intestinal fistula (HP:0100819)3.49178126
41Poikiloderma (HP:0001029)3.44486254
42Abnormality of fatty-acid metabolism (HP:0004359)3.35695105
43Hyperbilirubinemia (HP:0002904)3.34597919
44Popliteal pterygium (HP:0009756)3.32679176
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27532543
46Abnormality of nucleobase metabolism (HP:0010932)3.19677861
47Delayed CNS myelination (HP:0002188)3.19214512
48Steatorrhea (HP:0002570)3.18050510
49Ketoacidosis (HP:0001993)3.13788058
50Congenital stationary night blindness (HP:0007642)3.13152102
51Choroideremia (HP:0001139)3.10500829
52Hepatocellular carcinoma (HP:0001402)3.07274925
53Abnormality of serum amino acid levels (HP:0003112)3.06231858
54Abnormality of purine metabolism (HP:0004352)2.93326788
55Acanthocytosis (HP:0001927)2.90034223
56Bony spicule pigmentary retinopathy (HP:0007737)2.89167515
57Myocardial infarction (HP:0001658)2.86499721
58Metabolic acidosis (HP:0001942)2.85744241
59Spontaneous abortion (HP:0005268)2.81641088
60Skin nodule (HP:0200036)2.77802379
61Hypochromic microcytic anemia (HP:0004840)2.76265185
62Anteriorly placed anus (HP:0001545)2.76241716
63Short chin (HP:0000331)2.75436439
64Turricephaly (HP:0000262)2.75019062
65Gout (HP:0001997)2.73424920
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.72903955
67Vascular calcification (HP:0004934)2.72760859
68Facial diplegia (HP:0001349)2.71595634
69Systemic lupus erythematosus (HP:0002725)2.67064421
70Lethargy (HP:0001254)2.61489249
71Dicarboxylic aciduria (HP:0003215)2.57709401
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57709401
73Malnutrition (HP:0004395)2.52136018
74Chorioretinal atrophy (HP:0000533)2.51373654
75Thin bony cortex (HP:0002753)2.49954045
76Akinesia (HP:0002304)2.47731537
77Hypoglycemic seizures (HP:0002173)2.47730140
78Abnormal albumin level (HP:0012116)2.45786892
79Hypoalbuminemia (HP:0003073)2.45786892
80Enlarged epiphyses (HP:0010580)2.45430328
81Lipid accumulation in hepatocytes (HP:0006561)2.44253613
82Pigmentary retinal degeneration (HP:0001146)2.44056169
83Spastic diplegia (HP:0001264)2.43207370
84Widely patent fontanelles and sutures (HP:0004492)2.42970178
85Cardiovascular calcification (HP:0011915)2.40847785
86Increased hepatocellular lipid droplets (HP:0006565)2.39581620
87Glomerulonephritis (HP:0000099)2.38853116
88Abnormal gallbladder morphology (HP:0012437)2.37837373
89Aplasia of the musculature (HP:0100854)2.37812821
90Short humerus (HP:0005792)2.35135334
91Cerebral edema (HP:0002181)2.34978567
92Chronic hepatic failure (HP:0100626)2.34858039
93Irritability (HP:0000737)2.33377427
94Mitral stenosis (HP:0001718)2.32182010
95Cholelithiasis (HP:0001081)2.30324714
96Neonatal onset (HP:0003623)2.28299768
97Recurrent gram-negative bacterial infections (HP:0005420)2.26059358
98Squamous cell carcinoma (HP:0002860)2.24557646
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.24315562
100Mesangial abnormality (HP:0001966)2.23668710
101Esophageal varix (HP:0002040)2.23646625
102Pancreatitis (HP:0001733)2.21577241
103Sensorimotor neuropathy (HP:0007141)2.21301692
104Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19443500
105Generalized aminoaciduria (HP:0002909)2.18791837
106Annular pancreas (HP:0001734)2.18530662
107Cholecystitis (HP:0001082)2.17360751
108Abnormal gallbladder physiology (HP:0012438)2.17360751
109Patellar aplasia (HP:0006443)2.16755017
110Facial hemangioma (HP:0000329)2.15940454
111Azoospermia (HP:0000027)2.15644559
112Abnormality of proline metabolism (HP:0010907)2.15171001
113Hydroxyprolinuria (HP:0003080)2.15171001
114Alkalosis (HP:0001948)2.14712883
115Abnormality of homocysteine metabolism (HP:0010919)2.14556182
116Homocystinuria (HP:0002156)2.14556182
117Abnormal urine phosphate concentration (HP:0012599)2.14006462
118Enlarged kidneys (HP:0000105)2.13988457
119Menorrhagia (HP:0000132)2.13660042
120Poikilocytosis (HP:0004447)2.10496207
121Vomiting (HP:0002013)2.10043165
122Delayed epiphyseal ossification (HP:0002663)2.08943934
123Flat occiput (HP:0005469)2.08007220
124Late onset (HP:0003584)2.08003653
125Rickets (HP:0002748)2.07694626
126Fetal akinesia sequence (HP:0001989)2.06246619
127Reduced antithrombin III activity (HP:0001976)2.05959785
128Aplasia/hypoplasia of the humerus (HP:0006507)2.05942833
129Hypothermia (HP:0002045)2.05017175
130Gingival bleeding (HP:0000225)2.04253486
131Amniotic constriction ring (HP:0009775)2.04027975
132Abnormality of placental membranes (HP:0011409)2.04027975
133Amyloidosis (HP:0011034)2.03560038
134Ulnar bowing (HP:0003031)2.02835618
135Decreased circulating renin level (HP:0003351)2.02666940
136Decreased central vision (HP:0007663)2.02273223
137Brushfield spots (HP:0001088)2.01397733
138Megaloblastic anemia (HP:0001889)2.01303949
139Renal Fanconi syndrome (HP:0001994)2.00170778
140Opisthotonus (HP:0002179)2.00095864
141Aplasia/Hypoplasia of the patella (HP:0006498)1.98206401
142Proximal tubulopathy (HP:0000114)1.96574760
143Thrombophlebitis (HP:0004418)1.96158266
144Cheilitis (HP:0100825)1.96018693
145Abnormality of the gallbladder (HP:0005264)1.95553867
146Hyperinsulinemic hypoglycemia (HP:0000825)1.95476259
147Abnormal enzyme/coenzyme activity (HP:0012379)1.95154046
148Hemorrhage of the eye (HP:0011885)1.94254247
149Glycosuria (HP:0003076)1.93770764
150Abnormality of urine glucose concentration (HP:0011016)1.93770764
151Increased purine levels (HP:0004368)1.91387687
152Hyperuricemia (HP:0002149)1.91387687
153Absent thumb (HP:0009777)1.91268952
154Right ventricular cardiomyopathy (HP:0011663)1.90014910
155Epiphyseal stippling (HP:0010655)1.88272940
156Abnormal epiphyseal ossification (HP:0010656)1.87992006
157Renal cortical cysts (HP:0000803)1.87835240
158Hypophosphatemic rickets (HP:0004912)1.86830263
159Renal tubular dysfunction (HP:0000124)1.86763161
160Abnormal cartilage morphology (HP:0002763)1.85440898
161Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85211823
162Atrioventricular block (HP:0001678)1.84678066
163Abnormality of vitamin metabolism (HP:0100508)1.84606671
164Cystic hygroma (HP:0000476)1.84247017
165Absent radius (HP:0003974)1.83555298
166Abnormality of the hepatic vasculature (HP:0006707)1.82757814
167Elevated hepatic transaminases (HP:0002910)1.82687999
168Hypoplastic nipples (HP:0002557)1.77678362
169Abnormal biliary tract morphology (HP:0012440)1.76072658
170Narrow nasal bridge (HP:0000446)1.74891068
171Aplasia involving forearm bones (HP:0009822)1.71276178

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.70043855
2SIK14.58149700
3FGFR44.15371307
4ERN13.98965754
5PIM23.41625210
6INSRR3.35916648
7TAOK33.25312842
8TNIK3.20646821
9ERBB43.02327935
10BMPR1B2.86213310
11MST1R2.83092040
12FRK2.68471643
13MAP2K42.12802071
14LATS12.08672805
15STK162.05178737
16BCR2.04124214
17STK392.00793182
18MAPK111.96822736
19CASK1.94318541
20ACVR1B1.92948989
21PKN21.85761417
22PIK3CG1.78458698
23FLT31.78416031
24TRIM281.68454591
25MST41.63426700
26TYK21.61958568
27BRSK21.60927399
28FER1.60134307
29TNK21.60091060
30PTK61.54288501
31EIF2AK11.40983541
32NEK91.37004943
33FGFR21.35584174
34LMTK21.32858006
35MAP3K71.32824533
36ABL21.32189110
37DAPK21.30016207
38PRKAA21.22642913
39NLK1.22271846
40STK38L1.21672770
41MARK11.20129779
42MAP3K41.19326427
43TAOK11.19200634
44CAMK1G1.17080686
45WNK11.16091936
46KDR1.15587026
47TRIB31.14468451
48JAK21.14453313
49GRK61.13789239
50ERBB21.12795067
51MAP3K141.12689939
52EIF2AK31.11698648
53MKNK21.07338624
54MET1.04503777
55STK111.00487344
56PINK10.99065953
57MAP2K70.97954772
58JAK10.97377888
59MAP3K100.95724236
60TBK10.95580056
61CSNK1A1L0.93851470
62ERBB30.93745729
63IRAK30.92545052
64ZAK0.91515272
65MAP2K30.90943749
66PRKD30.89717359
67MUSK0.88773184
68MAPK40.88425946
69PRKCZ0.87974405
70RIPK10.87051283
71SGK30.85338237
72TIE10.82416035
73CAMKK20.82128229
74CDK120.82093804
75MAP3K30.80553087
76TLK10.78220575
77PNCK0.77817952
78PRKAA10.77609077
79PRKCI0.77184245
80ADRBK10.76000990
81CCNB10.74561591
82EPHB10.74544331
83SGK20.72567359
84MAPK150.71884042
85MAP3K120.71820554
86CHEK20.70782468
87PRKACG0.69952957
88MAP2K60.69667653
89GRK10.68667293
90GSK3A0.67857599
91CDK60.66736292
92MAPK120.66344051
93CAMK2G0.64158774
94PIM10.63417900
95TESK20.62716187
96PHKG20.62589974
97PHKG10.62589974
98CSK0.61876463
99CDK80.61821612
100AKT30.61414939
101OXSR10.61122830
102CAMK1D0.61112706
103DYRK1B0.61042028
104CSNK1D0.60135148
105MAPK130.59208239
106MAPK70.58490527
107EPHA30.58321962
108ADRBK20.57925207
109WNK40.57289745
110PTK20.56893481
111SIK20.55367911
112NUAK10.54847706
113SGK2230.54805895
114SGK4940.54805895
115IKBKE0.54773099
116FGFR30.54556817
117PDPK10.53870636
118MAP3K110.53191670
119PRKCQ0.53128840
120MKNK10.52045837
121SIK30.51956812
122CSNK1E0.51769518
123RPS6KB10.51706822
124ATM0.51372005
125CSF1R0.48818567
126TGFBR20.48070458
127CSNK1G10.47929451
128PIK3CA0.46990544
129PRKCE0.46045904
130IGF1R0.42899193
131PDK40.42712262
132PDK30.42712262
133TAOK20.42312331
134MAPK80.41958463
135MINK10.40497204
136WNK30.39550972
137PBK0.39298972
138MAP3K20.39185256
139PKN10.35379183
140PRKD20.34795035
141MAP2K10.34644223
142MAP3K50.33698035
143NEK60.33195443
144AKT10.33001095
145TTK0.32320708
146EPHA40.32076158
147MAP2K20.31067313
148PDK10.30772206
149EPHA20.30428071
150GSK3B0.30405321
151NEK20.30287977
152EGFR0.29550271
153DYRK30.29534196
154RPS6KA30.29386674
155RET0.29337812
156MTOR0.29077195
157BMX0.28352160
158PRKCG0.28102924
159CDK40.28044063
160PRKCA0.27275521
161STK30.26981347
162MAP3K10.26858274
163MYLK0.25706519
164PRKG20.24942616
165CAMK40.23899988

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39453203
2Nitrogen metabolism_Homo sapiens_hsa009103.65532008
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.42184038
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.23902767
5Arginine biosynthesis_Homo sapiens_hsa002202.99171294
6Tryptophan metabolism_Homo sapiens_hsa003802.72147822
7Complement and coagulation cascades_Homo sapiens_hsa046102.62649713
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.60962626
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60148827
10Fatty acid degradation_Homo sapiens_hsa000712.49071106
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.46099205
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42303629
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33192332
14Butanoate metabolism_Homo sapiens_hsa006502.21697600
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11012688
16Peroxisome_Homo sapiens_hsa041462.09123756
17Propanoate metabolism_Homo sapiens_hsa006401.99054806
18Histidine metabolism_Homo sapiens_hsa003401.94641430
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.91432745
20Chemical carcinogenesis_Homo sapiens_hsa052041.90004394
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87623468
22PPAR signaling pathway_Homo sapiens_hsa033201.84497701
23Fatty acid metabolism_Homo sapiens_hsa012121.77477178
24Caffeine metabolism_Homo sapiens_hsa002321.76804348
25beta-Alanine metabolism_Homo sapiens_hsa004101.76034865
26Sphingolipid metabolism_Homo sapiens_hsa006001.75586532
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.74585106
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69858297
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69239577
30Retinol metabolism_Homo sapiens_hsa008301.68661828
31Staphylococcus aureus infection_Homo sapiens_hsa051501.65711709
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61137805
33Selenocompound metabolism_Homo sapiens_hsa004501.59604727
34Bile secretion_Homo sapiens_hsa049761.58642811
35Sulfur metabolism_Homo sapiens_hsa009201.52005732
36Phenylalanine metabolism_Homo sapiens_hsa003601.51793868
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50509533
38Starch and sucrose metabolism_Homo sapiens_hsa005001.40038572
39Pyruvate metabolism_Homo sapiens_hsa006201.37841332
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37398349
41Nicotine addiction_Homo sapiens_hsa050331.36859147
42Tyrosine metabolism_Homo sapiens_hsa003501.36621173
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36457734
44Fat digestion and absorption_Homo sapiens_hsa049751.29880321
45ABC transporters_Homo sapiens_hsa020101.26511608
46Fatty acid elongation_Homo sapiens_hsa000621.25772616
47Folate biosynthesis_Homo sapiens_hsa007901.24754249
48Circadian rhythm_Homo sapiens_hsa047101.24166403
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.22011477
50Steroid biosynthesis_Homo sapiens_hsa001001.17808493
51Basal transcription factors_Homo sapiens_hsa030221.17076641
52Biosynthesis of amino acids_Homo sapiens_hsa012301.13509719
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13114359
54Carbon metabolism_Homo sapiens_hsa012001.12692185
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.10113883
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07824758
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.07407584
58Vitamin digestion and absorption_Homo sapiens_hsa049771.07011913
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98220186
60Arginine and proline metabolism_Homo sapiens_hsa003300.98119375
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95503847
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94043595
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92899812
64Taste transduction_Homo sapiens_hsa047420.89513105
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88369600
66Vitamin B6 metabolism_Homo sapiens_hsa007500.88004584
67Sulfur relay system_Homo sapiens_hsa041220.87544497
68Lysine degradation_Homo sapiens_hsa003100.85341973
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85041860
70Non-homologous end-joining_Homo sapiens_hsa034500.81069564
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76094076
72Fanconi anemia pathway_Homo sapiens_hsa034600.73560267
73Glycerolipid metabolism_Homo sapiens_hsa005610.73198629
74Phototransduction_Homo sapiens_hsa047440.72399333
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71582342
76One carbon pool by folate_Homo sapiens_hsa006700.70282666
77Glutathione metabolism_Homo sapiens_hsa004800.69602994
78Pentose phosphate pathway_Homo sapiens_hsa000300.54327768
79Inositol phosphate metabolism_Homo sapiens_hsa005620.54056601
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53572711
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51923169
82Fatty acid biosynthesis_Homo sapiens_hsa000610.51185359
83Hedgehog signaling pathway_Homo sapiens_hsa043400.47334971
84Metabolic pathways_Homo sapiens_hsa011000.46467107
85N-Glycan biosynthesis_Homo sapiens_hsa005100.46449617
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45298002
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41388751
88mTOR signaling pathway_Homo sapiens_hsa041500.41351223
89Galactose metabolism_Homo sapiens_hsa000520.34772077
90Ether lipid metabolism_Homo sapiens_hsa005650.33409322
91Serotonergic synapse_Homo sapiens_hsa047260.29897481
92Prion diseases_Homo sapiens_hsa050200.29690901
93Fructose and mannose metabolism_Homo sapiens_hsa000510.29670010
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28661741
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28276559
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28048404
97Insulin secretion_Homo sapiens_hsa049110.27390287
98GABAergic synapse_Homo sapiens_hsa047270.26680046
99Glutamatergic synapse_Homo sapiens_hsa047240.26493092
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24421351
101Insulin resistance_Homo sapiens_hsa049310.23666917
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.19868249
103Linoleic acid metabolism_Homo sapiens_hsa005910.16794196
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16417183
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.15344815
106Glucagon signaling pathway_Homo sapiens_hsa049220.08401612
107Renin-angiotensin system_Homo sapiens_hsa046140.04439942
108AMPK signaling pathway_Homo sapiens_hsa041520.01054352
109Amoebiasis_Homo sapiens_hsa05146-0.2401037
110Bladder cancer_Homo sapiens_hsa05219-0.2400312
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2199577
112Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1938317
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1928967
114Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1721260
115Regulation of autophagy_Homo sapiens_hsa04140-0.1617030
116African trypanosomiasis_Homo sapiens_hsa05143-0.1596048
117Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1557282
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1472870
119Hepatitis C_Homo sapiens_hsa05160-0.1464542
120Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1368973
121Protein digestion and absorption_Homo sapiens_hsa04974-0.1314573
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1289637
123Insulin signaling pathway_Homo sapiens_hsa04910-0.1112492
124Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0839810
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0750442
126Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0681502
127Mineral absorption_Homo sapiens_hsa04978-0.0429782
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0252238

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