SLC10A7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte differentiation (GO:0030854)4.60736571
2imidazole-containing compound metabolic process (GO:0052803)4.37183081
3positive regulation of B cell differentiation (GO:0045579)4.34128554
4negative regulation of execution phase of apoptosis (GO:1900118)3.51163166
5lipid translocation (GO:0034204)3.46568135
6phospholipid translocation (GO:0045332)3.46568135
7cellular response to ethanol (GO:0071361)3.35680269
8ribonucleoprotein complex disassembly (GO:0032988)3.35295452
9DNA unwinding involved in DNA replication (GO:0006268)3.28021767
10early endosome to late endosome transport (GO:0045022)3.23716835
11methionine biosynthetic process (GO:0009086)3.23284802
12regulation of B cell differentiation (GO:0045577)3.23254290
13nuclear pore complex assembly (GO:0051292)3.17886414
14T cell migration (GO:0072678)3.16658085
15interferon-gamma secretion (GO:0072643)3.14432693
16DNA topological change (GO:0006265)3.13028213
17mitotic sister chromatid cohesion (GO:0007064)3.12462620
18COPII vesicle coating (GO:0048208)3.05029259
19organelle disassembly (GO:1903008)3.03161667
20gonadal mesoderm development (GO:0007506)2.99900896
21monoubiquitinated protein deubiquitination (GO:0035520)2.97526444
22protein targeting to vacuole (GO:0006623)2.94093599
23protein targeting to lysosome (GO:0006622)2.94093599
24establishment of protein localization to vacuole (GO:0072666)2.94093599
25regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.91668953
26positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.91668953
27positive regulation of mRNA catabolic process (GO:0061014)2.90881123
28positive regulation of mRNA 3-end processing (GO:0031442)2.89510614
29DNA strand elongation involved in DNA replication (GO:0006271)2.89199712
30nuclear pore organization (GO:0006999)2.87798929
31telomere maintenance via semi-conservative replication (GO:0032201)2.85248563
32RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.83628637
33poly(A)+ mRNA export from nucleus (GO:0016973)2.82171147
34pore complex assembly (GO:0046931)2.81753408
35negative regulation of adaptive immune response (GO:0002820)2.80930779
36intra-Golgi vesicle-mediated transport (GO:0006891)2.80250468
37protein localization to kinetochore (GO:0034501)2.79631385
38positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.79560783
39regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.79560783
40microtubule anchoring (GO:0034453)2.79336786
41mitochondrial calcium ion transport (GO:0006851)2.78873961
42mitotic recombination (GO:0006312)2.76622981
43RNA destabilization (GO:0050779)2.75495381
44methionine metabolic process (GO:0006555)2.74834933
45DNA strand elongation (GO:0022616)2.74528369
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.73667818
47meiotic chromosome segregation (GO:0045132)2.73219100
48telomere maintenance via recombination (GO:0000722)2.71773780
49regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.70714312
50protein K11-linked deubiquitination (GO:0035871)2.70475565
51mitochondrial DNA replication (GO:0006264)2.70313749
52DNA replication initiation (GO:0006270)2.69053300
53short-chain fatty acid metabolic process (GO:0046459)2.68257624
54peroxisome fission (GO:0016559)2.67981516
55intra-S DNA damage checkpoint (GO:0031573)2.65566078
56folic acid-containing compound biosynthetic process (GO:0009396)2.65178027
57regulation of Golgi to plasma membrane protein transport (GO:0042996)2.64353766
58ether lipid metabolic process (GO:0046485)2.61405710
59resolution of meiotic recombination intermediates (GO:0000712)2.60808113
60ADP metabolic process (GO:0046031)2.59614550
61neural tube formation (GO:0001841)2.59387936
62interleukin-6-mediated signaling pathway (GO:0070102)2.58682260
63aspartate family amino acid biosynthetic process (GO:0009067)2.57577938
64phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.57530612
65somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.56769442
66isotype switching (GO:0045190)2.56769442
67somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.56769442
68positive regulation by organism of defense response of other organism involved in symbiotic interact2.56207364
69modulation by symbiont of host immune response (GO:0052553)2.56207364
70positive regulation by symbiont of host defense response (GO:0052509)2.56207364
71modulation by symbiont of host defense response (GO:0052031)2.56207364
72modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.56207364
73modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.56207364
74AMP metabolic process (GO:0046033)2.55042347
75regulation of DNA endoreduplication (GO:0032875)2.53238988
76DNA replication checkpoint (GO:0000076)2.51012766
77negative thymic T cell selection (GO:0045060)2.47576766
78regulation of regulatory T cell differentiation (GO:0045589)2.47115958
79male meiosis I (GO:0007141)2.45699324
80negative regulation of mast cell activation (GO:0033004)2.43599073
81negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.43535951
82androgen receptor signaling pathway (GO:0030521)2.43462460
83positive regulation of humoral immune response (GO:0002922)2.42774293
84regulation of meiosis I (GO:0060631)2.40655544
85mitotic nuclear envelope disassembly (GO:0007077)2.40443522
86regulation of mRNA 3-end processing (GO:0031440)2.40438391
87regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.40308640
88DNA geometric change (GO:0032392)2.39965966
89DNA duplex unwinding (GO:0032508)2.39088198
90regulation of chromatin silencing (GO:0031935)2.38632421
91nerve growth factor signaling pathway (GO:0038180)2.37066041
92B cell receptor signaling pathway (GO:0050853)2.36681737
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.36180095
94rRNA catabolic process (GO:0016075)2.36051931
95sulfur amino acid biosynthetic process (GO:0000097)2.35551317
96regulation of chemokine secretion (GO:0090196)2.35308819
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.35293259
98regulation of mRNA catabolic process (GO:0061013)2.34974981
99sister chromatid cohesion (GO:0007062)2.34680307
100interkinetic nuclear migration (GO:0022027)2.34598708
101regulation of nuclear cell cycle DNA replication (GO:0033262)2.33884755
102negative regulation of B cell proliferation (GO:0030889)2.33779680
103regulation of T cell tolerance induction (GO:0002664)2.33372715
104sister chromatid segregation (GO:0000819)2.33027821
105kinetochore organization (GO:0051383)2.31252483
106positive regulation of gamma-delta T cell activation (GO:0046645)2.31083015
107negative T cell selection (GO:0043383)2.30983779
108telomere maintenance via telomere lengthening (GO:0010833)2.30871423
109meiotic cell cycle (GO:0051321)2.30378741
110cilium or flagellum-dependent cell motility (GO:0001539)2.29987524
111metaphase plate congression (GO:0051310)2.29786323
112ER to Golgi vesicle-mediated transport (GO:0006888)2.29551178
113macroautophagy (GO:0016236)2.29030327
114regulation of telomere maintenance via telomerase (GO:0032210)2.28553698
115positive regulation of chemokine secretion (GO:0090197)2.28546233
116regulation of germinal center formation (GO:0002634)2.28463543
117auditory receptor cell differentiation (GO:0042491)2.28272806
118pinocytosis (GO:0006907)2.28118016
119tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.28004856
120RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.28004856
121nucleotide-sugar biosynthetic process (GO:0009226)2.27151173
122establishment of chromosome localization (GO:0051303)2.26505839
123Golgi transport vesicle coating (GO:0048200)2.26064054
124COPI coating of Golgi vesicle (GO:0048205)2.26064054
125thrombin receptor signaling pathway (GO:0070493)2.25932400
126positive regulation of alpha-beta T cell proliferation (GO:0046641)2.25800691
127leukocyte aggregation (GO:0070486)2.25648927
128hepatocyte apoptotic process (GO:0097284)2.24477353
129pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.24409559
130regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.24166587
131translesion synthesis (GO:0019985)2.23683380
132regulation of gamma-delta T cell differentiation (GO:0045586)2.23534537
133mismatch repair (GO:0006298)2.21955555
134magnesium ion transport (GO:0015693)2.21722763
135regulation of histone H3-K9 methylation (GO:0051570)2.21445726
136positive regulation of chromosome segregation (GO:0051984)2.20684622
137mitotic G2/M transition checkpoint (GO:0044818)2.20198909
138protein localization to chromosome, centromeric region (GO:0071459)2.19549390
139neutrophil activation involved in immune response (GO:0002283)2.19325915
140mitotic chromosome condensation (GO:0007076)2.18790097
141nucleotide-excision repair, DNA gap filling (GO:0006297)2.17648398
142attachment of spindle microtubules to kinetochore (GO:0008608)2.17322822
143protein K6-linked ubiquitination (GO:0085020)2.16517898
144detection of molecule of bacterial origin (GO:0032490)2.15985516
145CENP-A containing nucleosome assembly (GO:0034080)2.15697451
146maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.14428577
147telomere maintenance (GO:0000723)2.12035332
148nuclear envelope disassembly (GO:0051081)2.12005878
149membrane disassembly (GO:0030397)2.12005878
150mitotic sister chromatid segregation (GO:0000070)2.11430027
151spindle assembly involved in mitosis (GO:0090307)2.10743704
152telomere organization (GO:0032200)2.10192675
153Arp2/3 complex-mediated actin nucleation (GO:0034314)2.09928985
154DNA-dependent DNA replication (GO:0006261)2.09505383
155response to peptidoglycan (GO:0032494)2.07057976
156chromatin remodeling at centromere (GO:0031055)2.06448125
157positive regulation of mitotic sister chromatid separation (GO:1901970)2.05954001
158positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.05954001
159positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.05954001
160mitotic metaphase plate congression (GO:0007080)2.04640568
161definitive hemopoiesis (GO:0060216)2.04153235
162regulation of B cell receptor signaling pathway (GO:0050855)2.02137243
163mitotic G2 DNA damage checkpoint (GO:0007095)2.01981848
164positive regulation of DNA-dependent DNA replication (GO:2000105)2.01820931
165DNA synthesis involved in DNA repair (GO:0000731)2.01081145
166replication fork processing (GO:0031297)2.00941071
167somatic hypermutation of immunoglobulin genes (GO:0016446)1.99462212
168somatic diversification of immune receptors via somatic mutation (GO:0002566)1.99462212
169lipopolysaccharide biosynthetic process (GO:0009103)1.98777477
170IMP biosynthetic process (GO:0006188)1.98445599
171radial glial cell differentiation (GO:0060019)1.98106143
172regulation of spindle organization (GO:0090224)1.97756796
173lipopolysaccharide metabolic process (GO:0008653)1.97582677
174response to laminar fluid shear stress (GO:0034616)1.97412422
175DNA damage induced protein phosphorylation (GO:0006975)1.97403878
176trophoblast giant cell differentiation (GO:0060707)1.95627258
177DNA replication-dependent nucleosome organization (GO:0034723)1.95187749
178DNA replication-dependent nucleosome assembly (GO:0006335)1.95187749
179cytokine secretion (GO:0050663)1.94421986
180regulation of gene silencing (GO:0060968)1.94243653
181DNA conformation change (GO:0071103)1.93548060
182wound healing, spreading of cells (GO:0044319)1.93104776
183DNA replication-independent nucleosome assembly (GO:0006336)1.92671915
184DNA replication-independent nucleosome organization (GO:0034724)1.92671915
185detection of external biotic stimulus (GO:0098581)1.92282266
186response to X-ray (GO:0010165)1.91713028
187DNA damage response, detection of DNA damage (GO:0042769)1.91698019
188antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G1.91250937
189detection of other organism (GO:0098543)1.90253315
190regulation of attachment of spindle microtubules to kinetochore (GO:0051988)1.89937341
191negative regulation of phagocytosis (GO:0050765)1.89413156
192negative regulation of interleukin-12 production (GO:0032695)1.88891249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.59641527
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.80741124
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51877275
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37793748
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.12712544
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.88413574
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82469817
8GATA1_22025678_ChIP-Seq_K562_Human2.80228579
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.77918425
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.73051772
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54592170
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.50138038
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.48184203
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23687999
15TAF15_26573619_Chip-Seq_HEK293_Human2.22030426
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21253502
17FUS_26573619_Chip-Seq_HEK293_Human2.13723917
18* IRF8_21731497_ChIP-ChIP_J774_Mouse2.10959299
19MYC_18555785_ChIP-Seq_MESCs_Mouse2.02244321
20IGF1R_20145208_ChIP-Seq_DFB_Human1.98548983
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.94380011
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93682560
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91847367
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89420952
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.86180990
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85964690
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84792879
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.83465787
29EWS_26573619_Chip-Seq_HEK293_Human1.78366529
30ELK1_19687146_ChIP-ChIP_HELA_Human1.78075700
31AR_21909140_ChIP-Seq_LNCAP_Human1.69954731
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66725722
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66004365
34SPI1_23547873_ChIP-Seq_NB4_Human1.65987463
35* MYB_26560356_Chip-Seq_TH2_Human1.65384889
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61349112
37* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60484156
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.60346757
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59176135
40ER_23166858_ChIP-Seq_MCF-7_Human1.58843741
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58526725
42* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57345958
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57320367
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56275827
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56272796
46SCL_19346495_ChIP-Seq_HPC-7_Human1.54714568
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52073212
48* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49711842
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47140039
50SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46781655
51MYB_26560356_Chip-Seq_TH1_Human1.44806705
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44174784
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44078898
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.43169721
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.42738478
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.41043135
57VDR_22108803_ChIP-Seq_LS180_Human1.37889742
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.37624376
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36598995
60MYC_22102868_ChIP-Seq_BL_Human1.36281317
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35745297
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35240424
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.35171399
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.33694980
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30721937
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.28871007
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28066624
68CBP_20019798_ChIP-Seq_JUKART_Human1.28066624
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27950618
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.27267950
71TFEB_21752829_ChIP-Seq_HELA_Human1.26759274
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26000754
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24726173
74* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23822787
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23501985
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20928982
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20699253
78* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20289705
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19430694
80MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19138148
81* VDR_23849224_ChIP-Seq_CD4+_Human1.18605883
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17900743
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17861061
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16776584
85CIITA_25753668_ChIP-Seq_RAJI_Human1.16736888
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16692074
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16241291
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15826260
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15425113
90* GBX2_23144817_ChIP-Seq_PC3_Human1.14786550
91* FOXP3_21729870_ChIP-Seq_TREG_Human1.14040779
92FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13985153
93* STAT3_23295773_ChIP-Seq_U87_Human1.13730249
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12744108
95TP63_17297297_ChIP-ChIP_HaCaT_Human1.12300781
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12238535
97CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11706474
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11160583
99NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10697512
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10684214
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09735945
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.09685999
103IRF1_19129219_ChIP-ChIP_H3396_Human1.09574016
104NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09202917
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09000238
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08276735
107GATA3_27048872_Chip-Seq_THYMUS_Human1.08006102
108GATA3_26560356_Chip-Seq_TH2_Human1.07682402
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.07284461
110* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06777959
111VDR_21846776_ChIP-Seq_THP-1_Human1.05407893
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.05200071
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.03953874
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.03833167
115RUNX_20019798_ChIP-Seq_JUKART_Human1.03140059
116SMAD_19615063_ChIP-ChIP_OVARY_Human1.02585532
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02574990
118SALL4_22934838_ChIP-ChIP_CD34+_Human1.02193057
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01988946
120E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01717433
121FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.00959958
122KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00874461
123KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00874461
124KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00874461
125CDX2_22108803_ChIP-Seq_LS180_Human0.98312258
126* SMAD4_21799915_ChIP-Seq_A2780_Human0.96887722
127BRD4_25478319_ChIP-Seq_HGPS_Human0.96699844
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96370638
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95927689
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95136204
131P53_22387025_ChIP-Seq_ESCs_Mouse0.94294537
132RUNX1_22412390_ChIP-Seq_EML_Mouse0.93991658
133YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93335964
134SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.92728202
135Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91961420
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91481742
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.91374953
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90926491
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90811339
140FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90367724
141SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90358373
142SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90358373
143DCP1A_22483619_ChIP-Seq_HELA_Human0.89310483
144VDR_24763502_ChIP-Seq_THP-1_Human0.87733948
145HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87465096
146PU_27001747_Chip-Seq_BMDM_Mouse0.87338689
147TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85414674
148MAF_26560356_Chip-Seq_TH1_Human0.85413554
149PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85265018
150UTX_26944678_Chip-Seq_JUKART_Human0.85132077
151GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84713931
152RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83773589
153STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82595472
154KDM5A_27292631_Chip-Seq_BREAST_Human0.82243466
155MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80964016
156JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.79883123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence2.94977185
2MP0008057_abnormal_DNA_replication2.83627994
3MP0003183_abnormal_peptide_metabolism2.50388567
4MP0003693_abnormal_embryo_hatching2.32192134
5MP0002396_abnormal_hematopoietic_system2.25320828
6MP0010094_abnormal_chromosome_stability2.19667190
7MP0003656_abnormal_erythrocyte_physiolo2.15772893
8MP0008438_abnormal_cutaneous_collagen2.11233724
9MP0003111_abnormal_nucleus_morphology2.07563603
10MP0003718_maternal_effect1.97934021
11MP0003077_abnormal_cell_cycle1.96119488
12MP0008058_abnormal_DNA_repair1.95429806
13MP0006054_spinal_hemorrhage1.91721704
14MP0010352_gastrointestinal_tract_polyps1.79335738
15MP0008877_abnormal_DNA_methylation1.78537533
16MP0001835_abnormal_antigen_presentation1.72149696
17MP0009278_abnormal_bone_marrow1.63931842
18MP0005174_abnormal_tail_pigmentation1.63654791
19MP0000490_abnormal_crypts_of1.60269145
20MP0002822_catalepsy1.58130528
21MP0008007_abnormal_cellular_replicative1.56813618
22MP0003806_abnormal_nucleotide_metabolis1.52979567
23MP0000383_abnormal_hair_follicle1.50761383
24MP0004957_abnormal_blastocyst_morpholog1.49918709
25MP0003950_abnormal_plasma_membrane1.49576661
26MP0001800_abnormal_humoral_immune1.49044714
27MP0002139_abnormal_hepatobiliary_system1.41101271
28MP0009333_abnormal_splenocyte_physiolog1.40895538
29MP0002452_abnormal_antigen_presenting1.40682969
30MP0002166_altered_tumor_susceptibility1.39873104
31MP0003566_abnormal_cell_adhesion1.38581549
32MP0000569_abnormal_digit_pigmentation1.37867716
33MP0004808_abnormal_hematopoietic_stem1.37079921
34MP0001790_abnormal_immune_system1.35657142
35MP0005387_immune_system_phenotype1.35657142
36MP0002419_abnormal_innate_immunity1.31069443
37MP0002006_tumorigenesis1.30710036
38MP0000372_irregular_coat_pigmentation1.29949495
39MP0008932_abnormal_embryonic_tissue1.29012224
40MP0003252_abnormal_bile_duct1.27629309
41MP0005085_abnormal_gallbladder_physiolo1.27134262
42MP0003300_gastrointestinal_ulcer1.25329051
43MP0002420_abnormal_adaptive_immunity1.24457927
44MP0001819_abnormal_immune_cell1.23530104
45MP0010307_abnormal_tumor_latency1.21949694
46MP0003763_abnormal_thymus_physiology1.21895335
47MP0002398_abnormal_bone_marrow1.21878139
48MP0005503_abnormal_tendon_morphology1.21500303
49MP0002723_abnormal_immune_serum1.19710634
50MP0001764_abnormal_homeostasis1.19094619
51MP0005000_abnormal_immune_tolerance1.18902115
52MP0003724_increased_susceptibility_to1.18723358
53MP0005671_abnormal_response_to1.18542728
54MP0001986_abnormal_taste_sensitivity1.17632781
55MP0009785_altered_susceptibility_to1.17107378
56MP0010329_abnormal_lipoprotein_level1.16940538
57MP0001879_abnormal_lymphatic_vessel1.16773681
58MP0000685_abnormal_immune_system1.15814172
59MP0003279_aneurysm1.15630935
60MP0001915_intracranial_hemorrhage1.15536756
61MP0002405_respiratory_system_inflammati1.15261994
62MP0003436_decreased_susceptibility_to1.14558907
63MP0005275_abnormal_skin_tensile1.14558498
64MP0003136_yellow_coat_color1.13653488
65MP0009840_abnormal_foam_cell1.13299527
66MP0000689_abnormal_spleen_morphology1.12562889
67MP0002009_preneoplasia1.11589415
68MP0000858_altered_metastatic_potential1.11069019
69MP0000371_diluted_coat_color1.10925300
70MP0003045_fibrosis1.10361472
71MP0010678_abnormal_skin_adnexa1.09155509
72MP0001545_abnormal_hematopoietic_system1.09128023
73MP0005397_hematopoietic_system_phenotyp1.09128023
74MP0001666_abnormal_nutrient_absorption1.08086392
75MP0005025_abnormal_response_to1.07386169
76MP0003868_abnormal_feces_composition1.06476559
77MP0001853_heart_inflammation1.06280318
78MP0005076_abnormal_cell_differentiation1.05828630
79MP0002722_abnormal_immune_system1.04499036
80MP0003448_altered_tumor_morphology1.04227269
81MP0010155_abnormal_intestine_physiology1.04014584
82MP0002098_abnormal_vibrissa_morphology1.03949303
83MP0000716_abnormal_immune_system1.03846736
84MP0000465_gastrointestinal_hemorrhage1.02381898
85MP0000350_abnormal_cell_proliferation1.02070569
86MP0006072_abnormal_retinal_apoptosis1.01831814
87MP0004883_abnormal_blood_vessel1.01295405
88MP0000613_abnormal_salivary_gland0.99790910
89MP0000703_abnormal_thymus_morphology0.99365135
90MP0005332_abnormal_amino_acid0.98199440
91MP0005257_abnormal_intraocular_pressure0.97228613
92MP0002019_abnormal_tumor_incidence0.96935621
93MP0002060_abnormal_skin_morphology0.96920889
94MP0002429_abnormal_blood_cell0.96134375
95MP0002933_joint_inflammation0.95313092
96MP0002148_abnormal_hypersensitivity_rea0.95077221
97MP0009115_abnormal_fat_cell0.94929225
98MP0001293_anophthalmia0.94776044
99MP0001873_stomach_inflammation0.93995725
100MP0008961_abnormal_basal_metabolism0.93326090
101MP0005023_abnormal_wound_healing0.92706622
102MP0003195_calcinosis0.92251138
103MP0003705_abnormal_hypodermis_morpholog0.91734285
104MP0000767_abnormal_smooth_muscle0.88919204
105MP0003221_abnormal_cardiomyocyte_apopto0.88738758
106MP0005220_abnormal_exocrine_pancreas0.88686643
107MP0003941_abnormal_skin_development0.88362976
108MP0000566_synostosis0.86817307
109MP0001851_eye_inflammation0.86756232
110MP0001533_abnormal_skeleton_physiology0.86711061
111MP0002277_abnormal_respiratory_mucosa0.85223302
112MP0001929_abnormal_gametogenesis0.85171237
113MP0005376_homeostasis/metabolism_phenot0.84521908
114MP0005645_abnormal_hypothalamus_physiol0.84505185
115MP0000733_abnormal_muscle_development0.84284310
116MP0002638_abnormal_pupillary_reflex0.83787404
117MP0009697_abnormal_copulation0.83767519
118MP0000609_abnormal_liver_physiology0.83733664
119MP0000015_abnormal_ear_pigmentation0.83712032
120MP0005647_abnormal_sex_gland0.83219218
121MP0005310_abnormal_salivary_gland0.83162660
122MP0003567_abnormal_fetal_cardiomyocyte0.83106831
123MP0005395_other_phenotype0.82613003
124MP0002876_abnormal_thyroid_physiology0.82477204
125MP0003091_abnormal_cell_migration0.82028816
126MP0005365_abnormal_bile_salt0.81784447
127MP0001243_abnormal_dermal_layer0.81632202
128MP0004264_abnormal_extraembryonic_tissu0.79645588
129MP0005390_skeleton_phenotype0.79466491
130MP0005164_abnormal_response_to0.78462907
131MP0004947_skin_inflammation0.78009962
132MP0004197_abnormal_fetal_growth/weight/0.76834152
133MP0002086_abnormal_extraembryonic_tissu0.76723647
134MP0001845_abnormal_inflammatory_respons0.76242389
135MP0005451_abnormal_body_composition0.75000057
136MP0003786_premature_aging0.74741385
137MP0005408_hypopigmentation0.74706208
138MP0005464_abnormal_platelet_physiology0.73183861
139MP0005253_abnormal_eye_physiology0.73153287
140MP0000598_abnormal_liver_morphology0.72801130
141MP0003172_abnormal_lysosome_physiology0.71957345
142MP0005058_abnormal_lysosome_morphology0.71560014
143MP0006082_CNS_inflammation0.70694193
144MP0003943_abnormal_hepatobiliary_system0.69967251
145MP0002971_abnormal_brown_adipose0.69586872

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)3.99630723
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.93518869
3Renal cortical cysts (HP:0000803)3.80587343
4Autoimmune hemolytic anemia (HP:0001890)3.55787707
5Albinism (HP:0001022)3.17638605
6Acanthocytosis (HP:0001927)2.96706741
7Large for gestational age (HP:0001520)2.79161082
8Papillary thyroid carcinoma (HP:0002895)2.76389450
9Acute lymphatic leukemia (HP:0006721)2.71554641
10Ectopic kidney (HP:0000086)2.68451444
11IgM deficiency (HP:0002850)2.67262445
12Duplicated collecting system (HP:0000081)2.62767806
13Gingival bleeding (HP:0000225)2.61558101
14Abnormality of the renal collecting system (HP:0004742)2.53739400
15Recurrent abscess formation (HP:0002722)2.49777644
16Gonadotropin excess (HP:0000837)2.47700375
17Limb hypertonia (HP:0002509)2.39193356
18Abnormality of the prostate (HP:0008775)2.38336313
19Abnormality of the renal cortex (HP:0011035)2.32930609
20Severe combined immunodeficiency (HP:0004430)2.31947434
21Neurodegeneration (HP:0002180)2.30176063
22Hypoplasia of the pons (HP:0012110)2.29519413
23Papilledema (HP:0001085)2.29099635
24Abnormality of the pons (HP:0007361)2.23258357
25Intestinal atresia (HP:0011100)2.22786226
26Prolonged bleeding time (HP:0003010)2.21074759
27Chronic mucocutaneous candidiasis (HP:0002728)2.18128115
28Recurrent cutaneous fungal infections (HP:0011370)2.18128115
29Abnormality of the fingertips (HP:0001211)2.15655312
30Tubulointerstitial nephritis (HP:0001970)2.15257803
31Recurrent viral infections (HP:0004429)2.15257624
32Abnormality of chromosome stability (HP:0003220)2.14257790
33Abnormality of alanine metabolism (HP:0010916)2.14140779
34Hyperalaninemia (HP:0003348)2.14140779
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14140779
36Abnormality of the common coagulation pathway (HP:0010990)2.13018291
37Poor head control (HP:0002421)2.09016735
38Hyperlipoproteinemia (HP:0010980)2.08390919
39Reticulocytopenia (HP:0001896)2.03904361
40Epidermoid cyst (HP:0200040)2.01486337
41Medial flaring of the eyebrow (HP:0010747)2.00904870
42Medulloblastoma (HP:0002885)2.00138326
43Gastrointestinal inflammation (HP:0004386)1.98896403
44Poikilocytosis (HP:0004447)1.98543886
45Thyroid carcinoma (HP:0002890)1.97806601
46T lymphocytopenia (HP:0005403)1.97610937
47Inflammation of the large intestine (HP:0002037)1.97360736
48Volvulus (HP:0002580)1.96210643
49Increased serum pyruvate (HP:0003542)1.95043143
50Birth length less than 3rd percentile (HP:0003561)1.92799831
51Premature rupture of membranes (HP:0001788)1.90265183
52Obstructive lung disease (HP:0006536)1.90071060
53Chronic obstructive pulmonary disease (HP:0006510)1.90071060
54Unilateral renal agenesis (HP:0000122)1.89226543
55Menstrual irregularities (HP:0000858)1.88631341
56Aplasia/Hypoplasia of the tibia (HP:0005772)1.88144012
57Eosinophilia (HP:0001880)1.87095483
58Episodic fever (HP:0001954)1.86505079
59Abnormality of T cell number (HP:0011839)1.85825933
60Recurrent fungal infections (HP:0002841)1.84457469
61Metaphyseal dysplasia (HP:0100255)1.83884311
62Eczematoid dermatitis (HP:0000976)1.83868421
63Meckel diverticulum (HP:0002245)1.83174832
64Abnormality of the ileum (HP:0001549)1.82294783
65Cellulitis (HP:0100658)1.80723619
66IgG deficiency (HP:0004315)1.80647111
67Pancreatic cysts (HP:0001737)1.79093465
68Type I transferrin isoform profile (HP:0003642)1.79050234
69Lymphoma (HP:0002665)1.78643338
70Recurrent sinusitis (HP:0011108)1.78371229
71Acute myeloid leukemia (HP:0004808)1.77338496
72Nonimmune hydrops fetalis (HP:0001790)1.77119960
73Aplasia/Hypoplasia of the uvula (HP:0010293)1.77094927
74Congenital primary aphakia (HP:0007707)1.77028359
75Recurrent pneumonia (HP:0006532)1.76733193
76Basal ganglia calcification (HP:0002135)1.76123345
77Breech presentation (HP:0001623)1.75791234
78Short tibia (HP:0005736)1.75384674
79Fair hair (HP:0002286)1.75319885
80Meningitis (HP:0001287)1.74693690
81Abnormality of T cell physiology (HP:0011840)1.74611044
82Recurrent bronchitis (HP:0002837)1.74343994
83Myelodysplasia (HP:0002863)1.73981994
84Prostate neoplasm (HP:0100787)1.73581447
85Pustule (HP:0200039)1.73213227
86Abnormality of the intrinsic pathway (HP:0010989)1.73074525
87Small epiphyses (HP:0010585)1.72892890
88Deep philtrum (HP:0002002)1.72749558
89Aplastic anemia (HP:0001915)1.71240893
90Encephalitis (HP:0002383)1.71044903
91Osteolytic defects of the phalanges of the hand (HP:0009771)1.70927778
92Osteolytic defects of the hand bones (HP:0009699)1.70927778
93Epistaxis (HP:0000421)1.70492280
94Prolonged partial thromboplastin time (HP:0003645)1.69994076
95Selective tooth agenesis (HP:0001592)1.69799566
96Autoimmune thrombocytopenia (HP:0001973)1.69628908
97Osteomyelitis (HP:0002754)1.69092270
9811 pairs of ribs (HP:0000878)1.68913559
99Absent radius (HP:0003974)1.68861375
100Cervical subluxation (HP:0003308)1.68662292
101Abnormality of T cells (HP:0002843)1.68444622
102Abnormality of methionine metabolism (HP:0010901)1.68360515
103Ectropion (HP:0000656)1.68097374
104Chronic diarrhea (HP:0002028)1.68048468
105Agnosia (HP:0010524)1.67675167
106Thyroiditis (HP:0100646)1.67652153
107Recurrent lower respiratory tract infections (HP:0002783)1.67348135
108Granulocytopenia (HP:0001913)1.66761494
109Exocrine pancreatic insufficiency (HP:0001738)1.66173423
110Hypergonadotropic hypogonadism (HP:0000815)1.65754741
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65736100
112Abnormal protein N-linked glycosylation (HP:0012347)1.65736100
113Abnormal protein glycosylation (HP:0012346)1.65736100
114Abnormal glycosylation (HP:0012345)1.65736100
115Abnormal delayed hypersensitivity skin test (HP:0002963)1.65643702
116Glioma (HP:0009733)1.65623557
117Blepharitis (HP:0000498)1.65187662
118IgA deficiency (HP:0002720)1.64752826
119Spontaneous hematomas (HP:0007420)1.64637480
120Reduced antithrombin III activity (HP:0001976)1.63933304
121Increased mean platelet volume (HP:0011877)1.63008076
122Chronic otitis media (HP:0000389)1.62371124
123Long eyelashes (HP:0000527)1.62013580
124Central scotoma (HP:0000603)1.61665450
125Upper limb muscle weakness (HP:0003484)1.61009999
126Supernumerary spleens (HP:0009799)1.59994551
127Curly hair (HP:0002212)1.59867604
128Leukopenia (HP:0001882)1.59769802
129B lymphocytopenia (HP:0010976)1.59677503
130Abnormality of B cell number (HP:0010975)1.59677503
131Submucous cleft hard palate (HP:0000176)1.59283959
132Colitis (HP:0002583)1.58986795
133Proximal tubulopathy (HP:0000114)1.58873630
134Agammaglobulinemia (HP:0004432)1.58782748
135Abnormality of the preputium (HP:0100587)1.58120683
136Neoplasm of striated muscle (HP:0009728)1.57577014
137Deviation of the thumb (HP:0009603)1.57528835
138Periodontitis (HP:0000704)1.57494646
139Azoospermia (HP:0000027)1.57292642
140Rhabdomyosarcoma (HP:0002859)1.56839335
141Neutropenia (HP:0001875)1.56561252
142Abnormal spermatogenesis (HP:0008669)1.56350593
143Abnormal platelet volume (HP:0011876)1.56216476
144Abnormality of DNA repair (HP:0003254)1.55853091
145Widely spaced teeth (HP:0000687)1.55770300
146Clubbing of toes (HP:0100760)1.55282495
147Cone-rod dystrophy (HP:0000548)1.55018862
148Overlapping toe (HP:0001845)1.54921361
149Dislocated radial head (HP:0003083)1.54858138
150Nephrogenic diabetes insipidus (HP:0009806)1.54843775
151Pancreatic islet-cell hyperplasia (HP:0004510)1.54013859
152Sparse lateral eyebrow (HP:0005338)1.53153895
153Spondylolisthesis (HP:0003302)1.52280390
154Aplasia involving forearm bones (HP:0009822)1.51638376
155Absent forearm bone (HP:0003953)1.51638376
156Myositis (HP:0100614)1.50926417
157Mesomelia (HP:0003027)1.50824536
158Abnormality of eosinophils (HP:0001879)1.50247547
159Abnormality of the nasal septum (HP:0000419)1.49942518
160Proximal placement of thumb (HP:0009623)1.49475548
161Lymphopenia (HP:0001888)1.49414890
162Recurrent bacterial skin infections (HP:0005406)1.47101279
163Bone marrow hypocellularity (HP:0005528)1.45434462
164Amaurosis fugax (HP:0100576)1.45292922
165Prominent nose (HP:0000448)1.45157927
166Cheilitis (HP:0100825)1.44937059
167Vacuolated lymphocytes (HP:0001922)1.44908065
168Leukocytosis (HP:0001974)1.44634098
169Limited elbow extension (HP:0001377)1.44572109
170Skull defect (HP:0001362)1.44216437
171Adrenal hypoplasia (HP:0000835)1.44003435
172Panhypogammaglobulinemia (HP:0003139)1.41960493
173Combined immunodeficiency (HP:0005387)1.41846135
174Abnormality of cells of the lymphoid lineage (HP:0012140)1.41805182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK32.92779958
2MAP3K42.56369133
3CAMKK22.37625369
4ZAK2.36156022
5CDK122.30122137
6EPHA22.19114807
7STK102.09511672
8ERBB32.06975284
9IRAK42.06902873
10NEK21.94060392
11WNK11.91880219
12BLK1.88877688
13MAP4K11.87761674
14CDC71.82860596
15PDK21.80672169
16STK391.77327584
17STK31.74848547
18TEC1.74218729
19BMPR21.65303963
20TTK1.65114179
21MAP4K21.60519400
22JAK31.53654597
23EIF2AK31.45881471
24WEE11.43642976
25TRPM71.41750379
26TNIK1.39105931
27TXK1.38505989
28TNK21.37605896
29MAP2K71.37398378
30PASK1.36974138
31CLK11.36740578
32CDK71.36360828
33MAP3K141.34042250
34SRPK11.33382449
35SYK1.33082190
36RIPK41.31560559
37WNK41.31510382
38EEF2K1.31205343
39ERN11.30688440
40ATR1.30415826
41MST41.29150074
42MAP3K101.27893320
43PLK41.27767813
44ACVR1B1.27373774
45RPS6KA41.26569708
46TRIM281.26565783
47RPS6KB21.20892848
48RAF11.17231892
49STK41.16736289
50PIM11.15190942
51SCYL21.15082803
52TGFBR11.11562386
53FLT31.09141029
54FGFR31.09060628
55CSF1R1.08768586
56EIF2AK21.08393142
57ZAP701.06801653
58BTK1.06533574
59PBK1.06445206
60AKT31.05381486
61TAOK31.04943260
62ITK1.04818393
63STK241.04203701
64MKNK11.01309052
65NME11.00419154
66TYK20.99564733
67MAP3K20.99514353
68STK160.99236684
69CSK0.98350960
70PNCK0.98116555
71TIE10.96595832
72BRD40.95715781
73BUB10.95477691
74SIK20.94563549
75LATS10.94134721
76IKBKB0.94088841
77KSR20.94088032
78MAP3K80.93064942
79TAF10.92722888
80EPHA30.91281536
81AURKB0.90947024
82CHUK0.90744840
83BRSK20.87392652
84NUAK10.86033329
85MKNK20.85826871
86VRK10.85747347
87TGFBR20.85196709
88CHEK20.85112308
89IRAK10.84618990
90PLK10.83805092
91CDK40.79969561
92BMPR1B0.79775905
93KDR0.77194015
94CDK80.76697207
95IKBKE0.75022041
96MELK0.74576671
97CDK30.74036895
98JAK20.73820279
99DYRK30.73567614
100ATM0.73458045
101RPS6KA50.72566049
102NLK0.72049309
103MAP3K50.71443875
104YES10.69896183
105FRK0.69369310
106RIPK10.69047102
107PRKCQ0.69010174
108NEK60.67278773
109NME20.65948692
110MAPKAPK30.65941575
111TLK10.65773150
112FER0.65420261
113LRRK20.64790199
114GRK10.64073480
115KSR10.63178616
116JAK10.61678916
117TSSK60.61172928
118CHEK10.61073478
119CDK60.60409711
120LYN0.60308885
121PRPF4B0.58328682
122KIT0.57864162
123PLK30.56227440
124SIK10.55653826
125LCK0.55096524
126EPHB10.54795549
127BCR0.54085501
128EIF2AK10.53931695
129HCK0.52035314
130GRK60.51256194
131PTK60.50946756
132MAP3K60.50873508
133PIK3CG0.50732043
134INSRR0.50593526
135NEK10.50593042
136NEK90.49576634
137CAMK1D0.48801477
138MET0.47667974
139EGFR0.43790694
140MAPK70.42773192
141PINK10.41930125
142PRKCE0.41216415
143RPS6KB10.41002471
144RET0.40412059
145PLK20.39825113

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.03828670
2Mismatch repair_Homo sapiens_hsa034302.46262967
3Homologous recombination_Homo sapiens_hsa034402.26792426
4Non-homologous end-joining_Homo sapiens_hsa034502.26484530
5Selenocompound metabolism_Homo sapiens_hsa004502.17782802
6Base excision repair_Homo sapiens_hsa034102.14329304
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.14257779
8Dorso-ventral axis formation_Homo sapiens_hsa043202.06874344
9Cell cycle_Homo sapiens_hsa041102.02895822
10Fanconi anemia pathway_Homo sapiens_hsa034602.01345611
11One carbon pool by folate_Homo sapiens_hsa006701.96392112
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94296666
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.92917029
14Fatty acid elongation_Homo sapiens_hsa000621.83991733
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.83855371
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.70950196
17Primary immunodeficiency_Homo sapiens_hsa053401.69947330
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66671872
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56295637
20Propanoate metabolism_Homo sapiens_hsa006401.50832286
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50289247
22p53 signaling pathway_Homo sapiens_hsa041151.49903704
23Protein export_Homo sapiens_hsa030601.46213423
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43927353
25Antigen processing and presentation_Homo sapiens_hsa046121.42730922
26Nucleotide excision repair_Homo sapiens_hsa034201.42080441
27Hematopoietic cell lineage_Homo sapiens_hsa046401.40834283
28RNA transport_Homo sapiens_hsa030131.40424040
29Linoleic acid metabolism_Homo sapiens_hsa005911.40080561
30Spliceosome_Homo sapiens_hsa030401.38128077
31Herpes simplex infection_Homo sapiens_hsa051681.38012719
32Butanoate metabolism_Homo sapiens_hsa006501.37201169
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.36829306
34Measles_Homo sapiens_hsa051621.36051102
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.35905863
36Sulfur metabolism_Homo sapiens_hsa009201.31444735
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30026525
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.29897881
39Basal transcription factors_Homo sapiens_hsa030221.26951458
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26586178
41ABC transporters_Homo sapiens_hsa020101.25685813
42Peroxisome_Homo sapiens_hsa041461.25159180
43Malaria_Homo sapiens_hsa051441.25143106
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22783536
45Leishmaniasis_Homo sapiens_hsa051401.21944893
46Other glycan degradation_Homo sapiens_hsa005111.21263492
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21248987
48Small cell lung cancer_Homo sapiens_hsa052221.14240971
49Ether lipid metabolism_Homo sapiens_hsa005651.14135899
50Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13873219
51Complement and coagulation cascades_Homo sapiens_hsa046101.12482069
52T cell receptor signaling pathway_Homo sapiens_hsa046601.12092284
53Systemic lupus erythematosus_Homo sapiens_hsa053221.11378083
54Viral carcinogenesis_Homo sapiens_hsa052031.11336210
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10687721
56Folate biosynthesis_Homo sapiens_hsa007901.10449673
57Legionellosis_Homo sapiens_hsa051341.09246472
58TGF-beta signaling pathway_Homo sapiens_hsa043501.08901398
59Pyrimidine metabolism_Homo sapiens_hsa002401.08838421
60MicroRNAs in cancer_Homo sapiens_hsa052061.07247624
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04874196
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04540053
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02326498
64RNA polymerase_Homo sapiens_hsa030201.01132264
65RNA degradation_Homo sapiens_hsa030180.99933005
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.99224604
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97732414
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97658295
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96923385
70Prostate cancer_Homo sapiens_hsa052150.96822501
71Caffeine metabolism_Homo sapiens_hsa002320.96421312
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95511268
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.94934532
74Epstein-Barr virus infection_Homo sapiens_hsa051690.94885825
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93386506
76Purine metabolism_Homo sapiens_hsa002300.93092976
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91795474
78Fat digestion and absorption_Homo sapiens_hsa049750.91618928
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91490418
80Graft-versus-host disease_Homo sapiens_hsa053320.90751346
81Apoptosis_Homo sapiens_hsa042100.90315703
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88844164
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88645734
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.87873253
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.87672648
86B cell receptor signaling pathway_Homo sapiens_hsa046620.87332377
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85981211
88ECM-receptor interaction_Homo sapiens_hsa045120.85796401
89HTLV-I infection_Homo sapiens_hsa051660.85346359
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85327851
91Chemical carcinogenesis_Homo sapiens_hsa052040.84853260
92mRNA surveillance pathway_Homo sapiens_hsa030150.84467983
93Shigellosis_Homo sapiens_hsa051310.83831445
94N-Glycan biosynthesis_Homo sapiens_hsa005100.83688374
95Osteoclast differentiation_Homo sapiens_hsa043800.83112142
96Fatty acid metabolism_Homo sapiens_hsa012120.83052080
97Viral myocarditis_Homo sapiens_hsa054160.82819245
98Hepatitis B_Homo sapiens_hsa051610.82554379
99Adherens junction_Homo sapiens_hsa045200.81514095
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.80444153
101Notch signaling pathway_Homo sapiens_hsa043300.80044317
102Toxoplasmosis_Homo sapiens_hsa051450.77585279
103Ribosome_Homo sapiens_hsa030100.75378129
104Taste transduction_Homo sapiens_hsa047420.75295486
105Renin-angiotensin system_Homo sapiens_hsa046140.74764781
106Autoimmune thyroid disease_Homo sapiens_hsa053200.74732959
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74579462
108Allograft rejection_Homo sapiens_hsa053300.72382680
109TNF signaling pathway_Homo sapiens_hsa046680.72231188
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72141688
111Platelet activation_Homo sapiens_hsa046110.72124671
112Chronic myeloid leukemia_Homo sapiens_hsa052200.71670378
113Influenza A_Homo sapiens_hsa051640.70753916
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69375414
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68231942
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.65091552
117Focal adhesion_Homo sapiens_hsa045100.64645816
118Melanoma_Homo sapiens_hsa052180.63559499
119Asthma_Homo sapiens_hsa053100.62179466
120Hepatitis C_Homo sapiens_hsa051600.62005435
121Sphingolipid metabolism_Homo sapiens_hsa006000.61910540
122Vitamin digestion and absorption_Homo sapiens_hsa049770.61680777
123Lysosome_Homo sapiens_hsa041420.59568255
124Nitrogen metabolism_Homo sapiens_hsa009100.59317254
125Lysine degradation_Homo sapiens_hsa003100.59221882
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55216006
127Staphylococcus aureus infection_Homo sapiens_hsa051500.54997711
128Steroid biosynthesis_Homo sapiens_hsa001000.54596244
129Pancreatic cancer_Homo sapiens_hsa052120.54425917
130Pathways in cancer_Homo sapiens_hsa052000.54383352
131Proteoglycans in cancer_Homo sapiens_hsa052050.54370314
132Proteasome_Homo sapiens_hsa030500.53365485
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52108490
134Retinol metabolism_Homo sapiens_hsa008300.51613592
135Tuberculosis_Homo sapiens_hsa051520.51391281
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.50787258
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49814596
138Sulfur relay system_Homo sapiens_hsa041220.48299492
139Arachidonic acid metabolism_Homo sapiens_hsa005900.48177076
140Pancreatic secretion_Homo sapiens_hsa049720.47739951
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47721915
142Fatty acid biosynthesis_Homo sapiens_hsa000610.46094176
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44659520

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