SLC11A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cysteine metabolic process (GO:0006534)4.56535878
2glycosphingolipid catabolic process (GO:0046479)4.39796517
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.38595740
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.38595740
5modulation by symbiont of host immune response (GO:0052553)4.38595740
6positive regulation by symbiont of host defense response (GO:0052509)4.38595740
7modulation by symbiont of host defense response (GO:0052031)4.38595740
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.38595740
9low-density lipoprotein particle clearance (GO:0034383)4.18034634
10ceramide catabolic process (GO:0046514)4.10093772
11response to lipoprotein particle (GO:0055094)4.05121663
12glycolipid catabolic process (GO:0019377)3.98733367
13lysine metabolic process (GO:0006553)3.97568243
14lysine catabolic process (GO:0006554)3.97568243
15cellular response to ethanol (GO:0071361)3.93046866
16sphingoid metabolic process (GO:0046519)3.88172573
17dicarboxylic acid biosynthetic process (GO:0043650)3.87825671
18oligosaccharide catabolic process (GO:0009313)3.87147512
19kynurenine metabolic process (GO:0070189)3.83936343
20regulation of vitamin D biosynthetic process (GO:0060556)3.77242389
21cellular response to thyroid hormone stimulus (GO:0097067)3.77131827
22sphingosine metabolic process (GO:0006670)3.76257959
23L-alpha-amino acid transmembrane transport (GO:1902475)3.74128091
24positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.73683976
25diol metabolic process (GO:0034311)3.73574138
26membrane lipid catabolic process (GO:0046466)3.68673478
27regulation of cholesterol storage (GO:0010885)3.60913613
28regulation of mononuclear cell migration (GO:0071675)3.58638526
29sphingolipid catabolic process (GO:0030149)3.52983843
30branching involved in labyrinthine layer morphogenesis (GO:0060670)3.52016980
31homocysteine metabolic process (GO:0050667)3.46641874
32positive regulation of heat generation (GO:0031652)3.44139136
33regulation of interferon-beta biosynthetic process (GO:0045357)3.39887294
34indole-containing compound catabolic process (GO:0042436)3.38651548
35indolalkylamine catabolic process (GO:0046218)3.38651548
36tryptophan catabolic process (GO:0006569)3.38651548
37macroautophagy (GO:0016236)3.38394259
38regulation of cholesterol homeostasis (GO:2000188)3.37108540
39positive regulation of interferon-alpha production (GO:0032727)3.36556387
40plasma lipoprotein particle clearance (GO:0034381)3.31398071
41urate metabolic process (GO:0046415)3.28750614
42positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.28082639
43osteoclast differentiation (GO:0030316)3.27523443
44sulfur amino acid catabolic process (GO:0000098)3.25593914
45regulation of chronic inflammatory response (GO:0002676)3.22689810
46apoptotic cell clearance (GO:0043277)3.22634518
47drug transmembrane transport (GO:0006855)3.18150555
48macrophage activation involved in immune response (GO:0002281)3.16534877
49regulation of interferon-alpha production (GO:0032647)3.16518102
50regulation of apoptotic cell clearance (GO:2000425)3.14766679
51import into cell (GO:0098657)3.12115369
52regulation of membrane protein ectodomain proteolysis (GO:0051043)3.11153434
53protoporphyrinogen IX metabolic process (GO:0046501)3.10090494
54vitamin transmembrane transport (GO:0035461)3.05600184
55valine metabolic process (GO:0006573)2.96718960
56drug transport (GO:0015893)2.95266242
57detection of molecule of bacterial origin (GO:0032490)2.94748086
58epithelial cell differentiation involved in prostate gland development (GO:0060742)2.94419787
59response to thyroid hormone (GO:0097066)2.92075866
60adhesion of symbiont to host (GO:0044406)2.90582369
61regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.90539728
62regulation of immunoglobulin secretion (GO:0051023)2.90305896
63regulation of fever generation (GO:0031620)2.89954990
64negative regulation of systemic arterial blood pressure (GO:0003085)2.89908128
65alpha-linolenic acid metabolic process (GO:0036109)2.87619677
66amyloid precursor protein catabolic process (GO:0042987)2.87375600
67protoporphyrinogen IX biosynthetic process (GO:0006782)2.85811241
68positive regulation of cellular amide metabolic process (GO:0034250)2.84097434
69triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.83196447
70intestinal cholesterol absorption (GO:0030299)2.82804446
71negative regulation of lipid storage (GO:0010888)2.82534762
72negative regulation of complement activation (GO:0045916)2.81434935
73protein-lipid complex assembly (GO:0065005)2.77033489
74transepithelial transport (GO:0070633)2.74877492
75positive regulation of tissue remodeling (GO:0034105)2.74328270
76adhesion of symbiont to host cell (GO:0044650)2.73058576
77virion attachment to host cell (GO:0019062)2.73058576
78modified amino acid transport (GO:0072337)2.71942091
79plasma lipoprotein particle assembly (GO:0034377)2.70814014
80serine family amino acid catabolic process (GO:0009071)2.70767107
81negative regulation of protein activation cascade (GO:2000258)2.69759235
82regulation of vitamin metabolic process (GO:0030656)2.69174421
83amine catabolic process (GO:0009310)2.66812393
84cellular biogenic amine catabolic process (GO:0042402)2.66812393
85fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.66180037
86ganglioside metabolic process (GO:0001573)2.64796709
87positive regulation of chemokine biosynthetic process (GO:0045080)2.63945481
88keratan sulfate catabolic process (GO:0042340)2.63798463
89establishment of protein localization to vacuole (GO:0072666)2.63728750
90protein targeting to vacuole (GO:0006623)2.63728750
91protein targeting to lysosome (GO:0006622)2.63728750
92cell adhesion mediated by integrin (GO:0033627)2.62378398
93positive regulation of steroid biosynthetic process (GO:0010893)2.61347338
94response to host immune response (GO:0052572)2.61304858
95response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.61304858
96urea cycle (GO:0000050)2.61121063
97urea metabolic process (GO:0019627)2.61121063
98tryptophan metabolic process (GO:0006568)2.60515832
99toxin transport (GO:1901998)2.60109023
100response to peptidoglycan (GO:0032494)2.59392479
101positive regulation of interferon-beta production (GO:0032728)2.59211544
102serine family amino acid metabolic process (GO:0009069)2.59125416
103negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.59096334
104very-low-density lipoprotein particle assembly (GO:0034379)2.58443523
105* iron ion import (GO:0097286)2.58044893
106pH reduction (GO:0045851)2.57693608
107cellular response to interferon-alpha (GO:0035457)2.57662435
108regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.57509231
109reverse cholesterol transport (GO:0043691)2.57422361
110positive regulation of bone remodeling (GO:0046852)2.56939492
111positive regulation of bone resorption (GO:0045780)2.56939492
112heme transport (GO:0015886)2.56677564
113antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.56487139
114cellular copper ion homeostasis (GO:0006878)2.56328066
115protein carboxylation (GO:0018214)2.56249421
116peptidyl-glutamic acid carboxylation (GO:0017187)2.56249421
117erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.56191513
118L-phenylalanine catabolic process (GO:0006559)2.56191513
119regulation of nitric oxide biosynthetic process (GO:0045428)2.56058651
120cholesterol efflux (GO:0033344)2.55933893
121positive regulation of lipid storage (GO:0010884)2.55595648
122glyoxylate metabolic process (GO:0046487)2.54512652
123positive regulation of cholesterol efflux (GO:0010875)2.53948451
124L-phenylalanine metabolic process (GO:0006558)2.53948367
125erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.53948367
126low-density lipoprotein particle remodeling (GO:0034374)2.53776211
127regulation of heat generation (GO:0031650)2.53395961
128cellular glucuronidation (GO:0052695)2.53323278
129I-kappaB phosphorylation (GO:0007252)2.52320754
130cellular modified amino acid catabolic process (GO:0042219)2.50980379
131regulation of early endosome to late endosome transport (GO:2000641)2.50776293
132intracellular pH reduction (GO:0051452)2.49798525
133positive regulation of fatty acid biosynthetic process (GO:0045723)2.48986819
134positive regulation of osteoclast differentiation (GO:0045672)2.48746174
135regulation of triglyceride catabolic process (GO:0010896)2.48733997
136regulation of lymphocyte chemotaxis (GO:1901623)2.48100314
137positive regulation of p38MAPK cascade (GO:1900745)2.47650184
138glucuronate metabolic process (GO:0019585)2.46140221
139uronic acid metabolic process (GO:0006063)2.46140221
140phospholipid homeostasis (GO:0055091)2.44989495
141tyrosine metabolic process (GO:0006570)2.44488234
142regulation of podosome assembly (GO:0071801)2.44050693
143response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.43348116
144response to host (GO:0075136)2.43348116
145response to host defenses (GO:0052200)2.43348116
146regulation of clathrin-mediated endocytosis (GO:2000369)2.40977233
147retina vasculature morphogenesis in camera-type eye (GO:0061299)2.40823512
148positive regulation of nitric oxide biosynthetic process (GO:0045429)2.40640689
149regulation of cholesterol biosynthetic process (GO:0045540)2.40378600
150positive regulation of lipoprotein lipase activity (GO:0051006)2.40345977
151positive regulation of triglyceride lipase activity (GO:0061365)2.40345977
152acute-phase response (GO:0006953)2.40153125
153ER overload response (GO:0006983)2.39879569
154positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.39812165
155amino-acid betaine metabolic process (GO:0006577)2.39504647
156modification by symbiont of host morphology or physiology (GO:0044003)2.39060949
157C4-dicarboxylate transport (GO:0015740)2.38715578
158N-acetylneuraminate metabolic process (GO:0006054)2.38665501
159cellular response to ATP (GO:0071318)2.38275099
160intestinal absorption (GO:0050892)2.37675713
161lipoprotein metabolic process (GO:0042157)2.37213905
162regulation of cytokine secretion involved in immune response (GO:0002739)2.36935666
163regulation of macrophage chemotaxis (GO:0010758)2.35492193
164regulation of vascular endothelial growth factor production (GO:0010574)2.32389463
165positive regulation of neurotransmitter secretion (GO:0001956)2.30946802
166UDP-N-acetylglucosamine metabolic process (GO:0006047)2.30800576
167positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.30406311
168pyrimidine-containing compound transmembrane transport (GO:0072531)2.29238001
169prostate gland growth (GO:0060736)2.27972721
170* iron ion transport (GO:0006826)2.27954269
171decidualization (GO:0046697)2.27846396
172phospholipid efflux (GO:0033700)2.27833584
173positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.25575606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.48097563
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.04288712
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.72271719
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.47592598
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.19554268
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90027113
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.66015684
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52596245
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.48460108
10* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.45007495
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.44133943
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.43823593
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.40594294
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.40186643
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38880624
16GATA1_22025678_ChIP-Seq_K562_Human2.27311596
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19787645
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13208812
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.10251629
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.08292534
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.06658152
22AHR_22903824_ChIP-Seq_MCF-7_Human2.05105294
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.02101128
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01451165
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01241154
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99793721
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.95385611
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.93318217
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.92395393
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91292729
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.90156665
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89666160
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87904038
34CLOCK_20551151_ChIP-Seq_293T_Human1.87823876
35* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86591058
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82356475
37* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77534521
38ZNF263_19887448_ChIP-Seq_K562_Human1.75464196
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71840074
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66267644
41FOXM1_26456572_ChIP-Seq_MCF-7_Human1.62153933
42* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.60479200
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.60466232
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59428282
45* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59402165
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.58569737
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.58371152
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57765279
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57444203
50* RACK7_27058665_Chip-Seq_MCF-7_Human1.57197453
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56908122
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56445489
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56095946
54GATA1_19941826_ChIP-Seq_K562_Human1.51441208
55ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49934919
56ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.49933979
57* GATA1_19941827_ChIP-Seq_MEL_Mouse1.49769318
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.49762536
59GATA6_25053715_ChIP-Seq_YYC3_Human1.49088863
60SALL1_21062744_ChIP-ChIP_HESCs_Human1.47607780
61* ATF3_27146783_Chip-Seq_COLON_Human1.46261542
62* GATA4_25053715_ChIP-Seq_YYC3_Human1.46028312
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44279094
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43791859
65CMYC_18555785_Chip-Seq_ESCs_Mouse1.43778808
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.43686758
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.43151606
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42992828
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.41320146
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41313363
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.41205636
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.38587190
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38218763
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37815863
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37318541
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.35268145
77P300_18555785_Chip-Seq_ESCs_Mouse1.34491629
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.34099221
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.33842829
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.32610832
81* STAT3_23295773_ChIP-Seq_U87_Human1.31911253
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31797531
83SOX2_18555785_Chip-Seq_ESCs_Mouse1.31549378
84GBX2_23144817_ChIP-Seq_PC3_Human1.31092611
85EZH2_27294783_Chip-Seq_NPCs_Mouse1.31063662
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30288481
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.28363723
88LXR_22292898_ChIP-Seq_THP-1_Human1.28328551
89OCT4_18555785_Chip-Seq_ESCs_Mouse1.28157105
90TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27906646
91* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27830026
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27608331
93ER_23166858_ChIP-Seq_MCF-7_Human1.27404218
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.26831608
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25926378
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25868244
97SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25830507
98PU1_27457419_Chip-Seq_LIVER_Mouse1.25640990
99CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25353984
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24891132
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24526976
102SMAD1_18555785_Chip-Seq_ESCs_Mouse1.24349202
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24348541
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23353330
105CDX2_22108803_ChIP-Seq_LS180_Human1.23258008
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22983273
107* GATA3_24758297_ChIP-Seq_MCF-7_Human1.22684394
108GATA2_19941826_ChIP-Seq_K562_Human1.22551231
109P300_19829295_ChIP-Seq_ESCs_Human1.21639925
110TP53_16413492_ChIP-PET_HCT116_Human1.21626373
111MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21577775
112P53_22387025_ChIP-Seq_ESCs_Mouse1.20587050
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20036414
114TP63_23658742_ChIP-Seq_EP156T_Human1.19349290
115TAF15_26573619_Chip-Seq_HEK293_Human1.19053603
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.18978076
117FLI1_27457419_Chip-Seq_LIVER_Mouse1.18712618
118SMAD3_21741376_ChIP-Seq_EPCs_Human1.18319449
119* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18247192
120SMAD4_21799915_ChIP-Seq_A2780_Human1.18222630
121TFEB_21752829_ChIP-Seq_HELA_Human1.17710304
122KLF4_18555785_Chip-Seq_ESCs_Mouse1.17106119
123SMAD3_21741376_ChIP-Seq_HESCs_Human1.16355343
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.15441463
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15247674
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.14876377
127PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14803211
128CJUN_26792858_Chip-Seq_BT549_Human1.14750721
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14445134
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14014857
131HNF4A_19822575_ChIP-Seq_HepG2_Human1.13867063
132EP300_21415370_ChIP-Seq_HL-1_Mouse1.13354718
133TCF4_23295773_ChIP-Seq_U87_Human1.12687515
134* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12101646
135ZFX_18555785_Chip-Seq_ESCs_Mouse1.12094731
136KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11842669
137* SOX2_20726797_ChIP-Seq_SW620_Human1.10947319
138KDM2B_26808549_Chip-Seq_DND41_Human1.10596250
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07107230
140KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05067572
141MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04618963
142HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03529281
143SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99592770
144RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99490987
145AR_21909140_ChIP-Seq_LNCAP_Human0.97086134
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97024966
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96986367
148GATA2_21666600_ChIP-Seq_HMVEC_Human0.96798552
149NCOR1_26117541_ChIP-Seq_K562_Human0.95884309
150* CREB1_26743006_Chip-Seq_LNCaP_Human0.94849533
151* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90842891
152* MAF_26560356_Chip-Seq_TH1_Human0.89897550
153CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89480472
154CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88197780
155SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87929413
156* UTX_26944678_Chip-Seq_JUKART_Human0.86972656
157RUNX1_27514584_Chip-Seq_MCF-7_Human0.86447805
158SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86117682
159SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86117682
160P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85607643
161UBF1/2_26484160_Chip-Seq_HMECs_Human0.85557173
162* MITF_21258399_ChIP-Seq_MELANOMA_Human0.85050672
163JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84389804
164NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84312537
165NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84312537
166CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.84263438
167KDM2B_26808549_Chip-Seq_K562_Human0.84209496
168STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82744416
169GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82409633
170VDR_24787735_ChIP-Seq_THP-1_Human0.82163923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.86668815
2MP0002139_abnormal_hepatobiliary_system3.83126643
3MP0009840_abnormal_foam_cell3.46131049
4MP0005058_abnormal_lysosome_morphology3.43802068
5MP0003195_calcinosis3.03643234
6MP0005167_abnormal_blood-brain_barrier2.81739244
7MP0006054_spinal_hemorrhage2.81593001
8MP0005365_abnormal_bile_salt2.68808792
9* MP0003656_abnormal_erythrocyte_physiolo2.68331112
10MP0010678_abnormal_skin_adnexa2.61243701
11MP0003191_abnormal_cellular_cholesterol2.59824617
12MP0000383_abnormal_hair_follicle2.50128454
13MP0006082_CNS_inflammation2.49673658
14MP0008875_abnormal_xenobiotic_pharmacok2.33886652
15MP0000604_amyloidosis2.28769430
16MP0005085_abnormal_gallbladder_physiolo2.23078078
17MP0003705_abnormal_hypodermis_morpholog2.22533443
18MP0005377_hearing/vestibular/ear_phenot2.19834176
19MP0003878_abnormal_ear_physiology2.19834176
20MP0000920_abnormal_myelination2.19277045
21MP0004947_skin_inflammation2.16549701
22MP0003252_abnormal_bile_duct2.16063596
23MP0005083_abnormal_biliary_tract2.10092903
24MP0005332_abnormal_amino_acid2.09659598
25MP0001666_abnormal_nutrient_absorption2.02571422
26MP0002148_abnormal_hypersensitivity_rea2.01262780
27MP0005257_abnormal_intraocular_pressure1.96079110
28MP0004264_abnormal_extraembryonic_tissu1.95177411
29MP0004233_abnormal_muscle_weight1.91624028
30MP0003300_gastrointestinal_ulcer1.84153737
31MP0003950_abnormal_plasma_membrane1.82255479
32MP0010329_abnormal_lipoprotein_level1.78803268
33MP0003172_abnormal_lysosome_physiology1.75749050
34MP0009278_abnormal_bone_marrow1.75400345
35MP0004019_abnormal_vitamin_homeostasis1.70447040
36* MP0000609_abnormal_liver_physiology1.62784606
37MP0004782_abnormal_surfactant_physiolog1.57387375
38MP0001853_heart_inflammation1.55524959
39MP0003303_peritoneal_inflammation1.54464393
40MP0003632_abnormal_nervous_system1.53672983
41MP0004043_abnormal_pH_regulation1.48318847
42MP0008438_abnormal_cutaneous_collagen1.46442097
43MP0003436_decreased_susceptibility_to1.45617048
44MP0009764_decreased_sensitivity_to1.42751154
45MP0009643_abnormal_urine_homeostasis1.41803520
46MP0001501_abnormal_sleep_pattern1.40478570
47MP0010234_abnormal_vibrissa_follicle1.38883383
48MP0005319_abnormal_enzyme/_coenzyme1.38694495
49MP0003806_abnormal_nucleotide_metabolis1.37797251
50MP0003329_amyloid_beta_deposits1.37123390
51MP0000647_abnormal_sebaceous_gland1.35673640
52MP0002877_abnormal_melanocyte_morpholog1.35336879
53MP0009785_altered_susceptibility_to1.34848863
54MP0001756_abnormal_urination1.33024712
55MP0005076_abnormal_cell_differentiation1.32251376
56MP0003453_abnormal_keratinocyte_physiol1.32131644
57MP0003690_abnormal_glial_cell1.31935395
58MP0005397_hematopoietic_system_phenotyp1.31354841
59MP0001545_abnormal_hematopoietic_system1.31354841
60MP0002098_abnormal_vibrissa_morphology1.31275877
61MP0005408_hypopigmentation1.31204412
62MP0000371_diluted_coat_color1.30783828
63MP0000569_abnormal_digit_pigmentation1.30238408
64MP0008469_abnormal_protein_level1.27479303
65MP0002118_abnormal_lipid_homeostasis1.27476307
66MP0005451_abnormal_body_composition1.22046185
67MP0004858_abnormal_nervous_system1.21699020
68MP0010307_abnormal_tumor_latency1.21445399
69MP0002138_abnormal_hepatobiliary_system1.20171064
70MP0001533_abnormal_skeleton_physiology1.20166837
71MP0003634_abnormal_glial_cell1.19164816
72MP0001958_emphysema1.18782842
73MP0003075_altered_response_to1.18649282
74MP0003045_fibrosis1.17801668
75MP0001984_abnormal_olfaction1.17794852
76MP0005646_abnormal_pituitary_gland1.17423187
77MP0002419_abnormal_innate_immunity1.17310879
78MP0005248_abnormal_Harderian_gland1.16448070
79MP0003941_abnormal_skin_development1.16307748
80MP0001324_abnormal_eye_pigmentation1.14450375
81MP0002998_abnormal_bone_remodeling1.12694863
82MP0009780_abnormal_chondrocyte_physiolo1.11350681
83MP0008004_abnormal_stomach_pH1.10735313
84MP0002653_abnormal_ependyma_morphology1.09318391
85MP0002136_abnormal_kidney_physiology1.08569687
86MP0002229_neurodegeneration1.07238446
87MP0005023_abnormal_wound_healing1.06110374
88MP0003633_abnormal_nervous_system1.05830705
89MP0005166_decreased_susceptibility_to1.03763518
90MP0002168_other_aberrant_phenotype1.02310785
91MP0003186_abnormal_redox_activity1.01927272
92MP0003631_nervous_system_phenotype1.01527703
93MP0005310_abnormal_salivary_gland1.01064872
94MP0003646_muscle_fatigue0.99670960
95MP0008260_abnormal_autophagy0.99382993
96* MP0005636_abnormal_mineral_homeostasis0.98811975
97MP0000598_abnormal_liver_morphology0.95899678
98MP0003890_abnormal_embryonic-extraembry0.94828616
99MP0000427_abnormal_hair_cycle0.94463834
100MP0005464_abnormal_platelet_physiology0.93498598
101MP0005025_abnormal_response_to0.92968865
102MP0004510_myositis0.92789180
103MP0002896_abnormal_bone_mineralization0.89549257
104MP0001727_abnormal_embryo_implantation0.88712231
105MP0003879_abnormal_hair_cell0.87907384
106MP0003091_abnormal_cell_migration0.87757175
107MP0001845_abnormal_inflammatory_respons0.87338100
108MP0003566_abnormal_cell_adhesion0.86845227
109MP0001919_abnormal_reproductive_system0.85803207
110MP0000685_abnormal_immune_system0.85512989
111MP0003724_increased_susceptibility_to0.84349273
112MP0010352_gastrointestinal_tract_polyps0.83559000
113MP0003448_altered_tumor_morphology0.81020389
114MP0004185_abnormal_adipocyte_glucose0.80775354
115MP0005584_abnormal_enzyme/coenzyme_acti0.80608335
116MP0001790_abnormal_immune_system0.80250303
117MP0005387_immune_system_phenotype0.80250303
118MP0005253_abnormal_eye_physiology0.80234456
119MP0009046_muscle_twitch0.79445983
120MP0002090_abnormal_vision0.78337396
121MP0001216_abnormal_epidermal_layer0.74928818
122MP0002295_abnormal_pulmonary_circulatio0.74355729
123MP0009333_abnormal_splenocyte_physiolog0.71808969
124MP0005647_abnormal_sex_gland0.71693071
125MP0001191_abnormal_skin_condition0.71284688
126MP0010155_abnormal_intestine_physiology0.70983672
127MP0004130_abnormal_muscle_cell0.70711430
128MP0001765_abnormal_ion_homeostasis0.70612649
129MP0001849_ear_inflammation0.70605648
130MP0003868_abnormal_feces_composition0.70488820
131* MP0005395_other_phenotype0.70053540
132MP0009763_increased_sensitivity_to0.69523607
133MP0005164_abnormal_response_to0.69190629
134MP0002332_abnormal_exercise_endurance0.68974739
135MP0000733_abnormal_muscle_development0.68372176
136MP0000343_altered_response_to0.67260940
137MP0005551_abnormal_eye_electrophysiolog0.66239448
138MP0000858_altered_metastatic_potential0.66230938
139MP0005000_abnormal_immune_tolerance0.65851117
140MP0000377_abnormal_hair_follicle0.65150885
141MP0005171_absent_coat_pigmentation0.64908133
142MP0000627_abnormal_mammary_gland0.63938896
143MP0004885_abnormal_endolymph0.63317505
144MP0002254_reproductive_system_inflammat0.63001792
145MP0002796_impaired_skin_barrier0.62272226
146MP0001881_abnormal_mammary_gland0.62005340
147MP0001243_abnormal_dermal_layer0.61834804

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.01019074
2Glomerulonephritis (HP:0000099)4.28946910
3Disinhibition (HP:0000734)4.08877991
4Abnormality of glutamine family amino acid metabolism (HP:0010902)3.73375489
5Increased cerebral lipofuscin (HP:0011813)3.62139188
6Abnormality of proline metabolism (HP:0010907)3.52474930
7Hydroxyprolinuria (HP:0003080)3.52474930
8Myocardial infarction (HP:0001658)3.21359000
9Cerebral inclusion bodies (HP:0100314)3.14047633
10Deep venous thrombosis (HP:0002625)3.09613163
11Mutism (HP:0002300)3.09105112
12Autoimmune thrombocytopenia (HP:0001973)3.07941443
13Systemic lupus erythematosus (HP:0002725)3.07797994
14Agnosia (HP:0010524)3.06954976
15Gout (HP:0001997)3.05584314
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.01311821
17Hyperglycinuria (HP:0003108)2.99939258
18Pustule (HP:0200039)2.97305590
19Xanthomatosis (HP:0000991)2.95858352
20Dysostosis multiplex (HP:0000943)2.91889965
21Vacuolated lymphocytes (HP:0001922)2.91622978
22Reticulocytosis (HP:0001923)2.90363140
23Osteolytic defects of the hand bones (HP:0009699)2.88195816
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.88195816
25Abnormality of glycine metabolism (HP:0010895)2.84187425
26Abnormality of serine family amino acid metabolism (HP:0010894)2.84187425
27Premature rupture of membranes (HP:0001788)2.80256996
28Hyperglycinemia (HP:0002154)2.79242664
29Nuclear cataract (HP:0100018)2.77559267
30Retinal atrophy (HP:0001105)2.76810671
31Intrahepatic cholestasis (HP:0001406)2.75170874
32Complement deficiency (HP:0004431)2.74895385
33Nausea (HP:0002018)2.74092104
34Inappropriate behavior (HP:0000719)2.70090754
35Abnormality of purine metabolism (HP:0004352)2.68167695
36Global brain atrophy (HP:0002283)2.65902732
37Apathy (HP:0000741)2.65382555
38Neuronal loss in central nervous system (HP:0002529)2.61904676
39Abnormality of sulfur amino acid metabolism (HP:0004339)2.61188955
40Abnormality of monocarboxylic acid metabolism (HP:0010996)2.60202678
41Abnormality of liposaccharide metabolism (HP:0010968)2.59122008
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.59122008
43Abnormality of glycolipid metabolism (HP:0010969)2.59122008
44Acanthocytosis (HP:0001927)2.58465929
45Poikilocytosis (HP:0004447)2.58046788
46Urinary glycosaminoglycan excretion (HP:0003541)2.56225979
47Mucopolysacchariduria (HP:0008155)2.56225979
48Personality changes (HP:0000751)2.55022846
49Abnormality of transition element cation homeostasis (HP:0011030)2.52479300
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51346569
51Abnormality of polysaccharide metabolism (HP:0011012)2.51346569
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51346569
53Diminished motivation (HP:0000745)2.51203348
54Ulnar bowing (HP:0003031)2.49412941
55Ileus (HP:0002595)2.46437539
56Metaphyseal irregularity (HP:0003025)2.45611791
57Vascular calcification (HP:0004934)2.43835949
58Cupped ribs (HP:0000887)2.42492090
59Fat malabsorption (HP:0002630)2.41461703
60Axonal loss (HP:0003447)2.41314791
61Abnormality of complement system (HP:0005339)2.37254158
62Tetraparesis (HP:0002273)2.35950580
63Cardiovascular calcification (HP:0011915)2.34355299
64Abnormality of the periventricular white matter (HP:0002518)2.31813470
65Alopecia of scalp (HP:0002293)2.31582854
66Vertebral compression fractures (HP:0002953)2.31151419
67Increased serum ferritin (HP:0003281)2.30826162
68Metaphyseal cupping (HP:0003021)2.30787970
69Polycythemia (HP:0001901)2.29818638
70Recurrent gram-negative bacterial infections (HP:0005420)2.28672268
71Abnormality of macrophages (HP:0004311)2.27576069
72Spastic tetraparesis (HP:0001285)2.24186844
73Curly hair (HP:0002212)2.24016585
74Turricephaly (HP:0000262)2.22228399
75Thick nail (HP:0001805)2.20239915
76Hyperammonemia (HP:0001987)2.18055100
77Abnormality of iron homeostasis (HP:0011031)2.15670527
78Hypoalphalipoproteinemia (HP:0003233)2.15581002
79Mitral stenosis (HP:0001718)2.15379279
80Hematochezia (HP:0002573)2.15356365
81Abnormality of the common coagulation pathway (HP:0010990)2.13061162
82Abnormality of nucleobase metabolism (HP:0010932)2.11711894
83Cardiomegaly (HP:0001640)2.10470478
84Esophageal varix (HP:0002040)2.10246017
85Hand muscle atrophy (HP:0009130)2.10210609
86Flat acetabular roof (HP:0003180)2.10041024
87Spastic diplegia (HP:0001264)2.09864803
88Steatorrhea (HP:0002570)2.05670843
89Hepatocellular carcinoma (HP:0001402)2.04916030
90Pathologic fracture (HP:0002756)2.04896504
91Sensorimotor neuropathy (HP:0007141)2.04614134
92Hypolipoproteinemia (HP:0010981)2.03044176
93Hypobetalipoproteinemia (HP:0003563)2.01357463
94Malnutrition (HP:0004395)2.00391841
95Amyloidosis (HP:0011034)2.00313231
96Progressive visual loss (HP:0000529)1.99018703
97Hypothermia (HP:0002045)1.98097589
98Abnormality of the Achilles tendon (HP:0005109)1.95460986
99Hyperventilation (HP:0002883)1.95050567
100Male infertility (HP:0003251)1.93738802
101Papillary thyroid carcinoma (HP:0002895)1.93645788
102Abnormal enzyme/coenzyme activity (HP:0012379)1.93127084
103Protuberant abdomen (HP:0001538)1.93079555
104Increased CSF protein (HP:0002922)1.92941042
105Pheochromocytoma (HP:0002666)1.92483038
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.92390354
107Cerebellar dysplasia (HP:0007033)1.90688690
108Cholelithiasis (HP:0001081)1.90582669
109Ketosis (HP:0001946)1.90173197
110Tubulointerstitial fibrosis (HP:0005576)1.89785898
111Paraparesis (HP:0002385)1.89060281
112Distal upper limb amyotrophy (HP:0007149)1.88948848
113Upper limb amyotrophy (HP:0009129)1.88948848
114Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87730991
115Cholecystitis (HP:0001082)1.87259894
116Abnormal gallbladder physiology (HP:0012438)1.87259894
117Skin nodule (HP:0200036)1.85718379
118Abnormality of alkaline phosphatase activity (HP:0004379)1.84369509
119Increased purine levels (HP:0004368)1.83949316
120Hyperuricemia (HP:0002149)1.83949316
121Nephritis (HP:0000123)1.83256749
122Interstitial pulmonary disease (HP:0006530)1.81625133
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81611558
124Abnormality of the heme biosynthetic pathway (HP:0010472)1.79970385
125Loss of speech (HP:0002371)1.79543002
126Abnormality of the nasal septum (HP:0000419)1.79114279
127Optic neuritis (HP:0100653)1.78249359
128Retrobulbar optic neuritis (HP:0100654)1.78249359
129Abnormal cartilage morphology (HP:0002763)1.76805764
130Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.76495411
131Cortical dysplasia (HP:0002539)1.73785857
132Urinary bladder sphincter dysfunction (HP:0002839)1.73213941
133Hyperlipoproteinemia (HP:0010980)1.72580864
134Peripheral demyelination (HP:0011096)1.72561005
135Albinism (HP:0001022)1.70194921
136Spastic paraplegia (HP:0001258)1.69484610
137Dementia (HP:0000726)1.69160350
138Abnormality of the vasculature of the conjunctiva (HP:0008054)1.68395770
139Lower limb hyperreflexia (HP:0002395)1.67767891
140Urinary incontinence (HP:0000020)1.67127605
141Abnormality of the lumbar spine (HP:0100712)1.62583663
142Epidermoid cyst (HP:0200040)1.61660919
143Prolonged neonatal jaundice (HP:0006579)1.61168072
144Blue irides (HP:0000635)1.56014383
145Symptomatic seizures (HP:0011145)1.53808283
146Supranuclear gaze palsy (HP:0000605)1.52894103
147Abnormality of the axillary hair (HP:0100134)1.51743863
148Abnormality of secondary sexual hair (HP:0009888)1.51743863
149Ascites (HP:0001541)1.51532009
150Pseudobulbar signs (HP:0002200)1.50561925
151Congenital primary aphakia (HP:0007707)1.48814371
152Biliary tract neoplasm (HP:0100574)1.48578040
153Paraplegia (HP:0010550)1.48333686
154Nephrogenic diabetes insipidus (HP:0009806)1.48217655
155Portal hypertension (HP:0001409)1.47991678
156Hyperaldosteronism (HP:0000859)1.47466434
157Thyroid carcinoma (HP:0002890)1.46840624
158Gait imbalance (HP:0002141)1.44850874
159Autoamputation (HP:0001218)1.41299428
160Dysdiadochokinesis (HP:0002075)1.39520332
161Hammertoe (HP:0001765)1.38898280
162Genetic anticipation (HP:0003743)1.36938159
163Action tremor (HP:0002345)1.36856271
164Beaking of vertebral bodies (HP:0004568)1.34826992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.22890737
2TRIB33.30975968
3ACVR1B2.97934325
4TBK12.91370195
5LATS12.77290498
6MST1R2.68477650
7EIF2AK32.65391181
8SIK12.43374168
9MATK2.40395633
10PBK2.30028620
11TYK22.27795257
12GRK72.21364651
13FGFR42.18077400
14BMX2.10441488
15STK31.94157655
16IRAK31.93225896
17PKN21.92862062
18MAP3K101.86704502
19TAOK31.85392820
20IKBKE1.85208077
21JAK11.82816107
22CASK1.76026410
23DDR21.75255250
24ADRBK21.74110039
25AKT31.73356850
26TGFBR21.69306764
27PTK61.68429485
28EPHB11.68068436
29NEK61.67721849
30ICK1.65599017
31STK38L1.62039015
32MET1.59258942
33FER1.57622601
34TAOK11.56750314
35BMPR21.54362261
36TSSK61.52706299
37EPHA21.47575307
38STK101.44669237
39CDK121.40296590
40RIPK41.35930752
41TTN1.33818816
42CDC42BPA1.31201996
43PDGFRA1.19522305
44MAP3K141.15958746
45JAK21.15623522
46BCKDK1.15532051
47CAMK1D1.14705869
48OXSR11.12405970
49RIPK11.10733219
50JAK31.09968534
51DAPK21.08976894
52BCR1.07720701
53ERBB41.07505210
54CAMKK21.05884225
55FGFR21.04617868
56MAP3K110.99803543
57CDK60.98749336
58MAP3K130.98614122
59MTOR0.98597206
60MAPK110.98467518
61BLK0.97796525
62PIK3CA0.96505513
63BRSK20.96028394
64ZAP700.95114252
65WNK40.94922439
66FGR0.92732215
67NTRK30.91844647
68MARK30.91370551
69PDGFRB0.90838354
70SIK30.90289276
71MAP3K30.89579797
72PDPK10.86790636
73CSK0.80535797
74FGFR10.80097412
75EPHA40.79717487
76IKBKB0.79206265
77STK40.78982894
78TYRO30.78526848
79TNIK0.77155482
80TRIM280.72335683
81ERBB30.72289454
82PLK20.71400450
83YES10.70973675
84NUAK10.70603075
85RPS6KA40.68917496
86BMPR1B0.68454505
87CDK40.67158308
88ABL20.66594134
89LRRK20.66523564
90PRKAA10.65083841
91MKNK10.64805134
92STK380.64712454
93TGFBR10.63770412
94RPS6KB10.62284384
95MAP3K80.61773376
96ERBB20.61755475
97STK390.61206487
98MAP2K30.58971059
99FRK0.57716953
100SGK30.57299842
101EGFR0.57173050
102WNK10.57143633
103SIK20.56785297
104CAMK1G0.56725481
105CSNK1A1L0.56381652
106NEK90.56308032
107TRPM70.55563927
108WNK30.55362741
109PDK20.55167823
110FGFR30.54355096
111PAK40.53928894
112MST40.53463229
113KSR10.51992988
114CHUK0.51963258
115PRKCE0.50540813
116BRD40.50487550
117MAP2K60.49616137
118PTK20.49405883
119ALK0.49294448
120GSK3A0.48083798
121INSRR0.47206472
122MAP3K50.47129967
123NME20.46932864
124ABL10.45557217
125PRKCH0.45465933
126MAP3K90.44349942
127PDK10.44032202
128TTK0.43408600
129SGK20.42949685
130MAP3K20.42731532
131NEK10.42535982
132NEK20.42394086
133SGK10.42376917
134KSR20.41031253
135FYN0.40905615
136MAP3K70.40896303
137MAP4K10.38877023
138PRKAA20.37727479
139EEF2K0.37468381
140MAPK100.36996902
141MELK0.36890380
142INSR0.36829239
143PIM20.35287146
144EIF2AK10.33312589
145LATS20.32512681
146PAK20.32318859
147CSNK1E0.31985077
148CSNK1A10.31831902

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006002.58026630
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28712603
3Staphylococcus aureus infection_Homo sapiens_hsa051502.23996188
4Arginine biosynthesis_Homo sapiens_hsa002202.14959477
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.13544283
6Vitamin B6 metabolism_Homo sapiens_hsa007501.99661029
7Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97266351
8* Lysosome_Homo sapiens_hsa041421.94868832
9Nitrogen metabolism_Homo sapiens_hsa009101.92413799
10Vitamin digestion and absorption_Homo sapiens_hsa049771.82537366
11Complement and coagulation cascades_Homo sapiens_hsa046101.72361251
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71181841
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71023438
14Collecting duct acid secretion_Homo sapiens_hsa049661.70944777
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70926836
16Folate biosynthesis_Homo sapiens_hsa007901.66431254
17Fatty acid degradation_Homo sapiens_hsa000711.64793902
18Fat digestion and absorption_Homo sapiens_hsa049751.62121576
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52810518
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.44530429
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44316594
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42352728
23Bile secretion_Homo sapiens_hsa049761.40663497
24Fatty acid metabolism_Homo sapiens_hsa012121.37743754
25Caffeine metabolism_Homo sapiens_hsa002321.37480989
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35540621
27Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34240217
28* Mineral absorption_Homo sapiens_hsa049781.32966427
29PPAR signaling pathway_Homo sapiens_hsa033201.32261813
30Circadian rhythm_Homo sapiens_hsa047101.27365786
31Ether lipid metabolism_Homo sapiens_hsa005651.25768203
32Selenocompound metabolism_Homo sapiens_hsa004501.24128608
33Malaria_Homo sapiens_hsa051441.17709169
34Butanoate metabolism_Homo sapiens_hsa006501.17494239
35Legionellosis_Homo sapiens_hsa051341.15854200
36Tryptophan metabolism_Homo sapiens_hsa003801.12904474
37Graft-versus-host disease_Homo sapiens_hsa053321.11443470
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.11073224
39ABC transporters_Homo sapiens_hsa020101.09650800
40TNF signaling pathway_Homo sapiens_hsa046681.08279672
41Sulfur relay system_Homo sapiens_hsa041221.08136190
42Peroxisome_Homo sapiens_hsa041461.05814792
43beta-Alanine metabolism_Homo sapiens_hsa004101.05683309
44Leishmaniasis_Homo sapiens_hsa051401.04748056
45Fatty acid biosynthesis_Homo sapiens_hsa000611.04699046
46Steroid biosynthesis_Homo sapiens_hsa001001.04336571
47Glycerolipid metabolism_Homo sapiens_hsa005611.03230050
48Tuberculosis_Homo sapiens_hsa051521.03042098
49Influenza A_Homo sapiens_hsa051641.02001561
50Vibrio cholerae infection_Homo sapiens_hsa051101.00934671
51Starch and sucrose metabolism_Homo sapiens_hsa005001.00517415
52Rheumatoid arthritis_Homo sapiens_hsa053231.00154216
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00130189
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.95135518
55Arginine and proline metabolism_Homo sapiens_hsa003300.93308321
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92646109
57NF-kappa B signaling pathway_Homo sapiens_hsa040640.92236193
58Cysteine and methionine metabolism_Homo sapiens_hsa002700.91992195
59Hepatitis C_Homo sapiens_hsa051600.91748829
60Prion diseases_Homo sapiens_hsa050200.91443747
61Amoebiasis_Homo sapiens_hsa051460.89480783
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.88743162
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86616226
64Bladder cancer_Homo sapiens_hsa052190.86167369
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85372632
66Measles_Homo sapiens_hsa051620.84393948
67Propanoate metabolism_Homo sapiens_hsa006400.84255679
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82177830
69Lysine degradation_Homo sapiens_hsa003100.82139376
70Chemical carcinogenesis_Homo sapiens_hsa052040.80215475
71Sulfur metabolism_Homo sapiens_hsa009200.79624085
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79338392
73Osteoclast differentiation_Homo sapiens_hsa043800.78941217
74Pertussis_Homo sapiens_hsa051330.78332644
75Protein digestion and absorption_Homo sapiens_hsa049740.74721560
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74407769
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74124174
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74102625
79Biosynthesis of amino acids_Homo sapiens_hsa012300.74077149
80Insulin resistance_Homo sapiens_hsa049310.73002171
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72674594
82Carbon metabolism_Homo sapiens_hsa012000.72150544
83Glutathione metabolism_Homo sapiens_hsa004800.71402336
84Renin-angiotensin system_Homo sapiens_hsa046140.70256170
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68302366
86Dorso-ventral axis formation_Homo sapiens_hsa043200.64770189
87N-Glycan biosynthesis_Homo sapiens_hsa005100.64417745
88Thyroid hormone synthesis_Homo sapiens_hsa049180.64001591
89Pentose phosphate pathway_Homo sapiens_hsa000300.62964016
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.61578782
91Retinol metabolism_Homo sapiens_hsa008300.61523825
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61519592
93Prolactin signaling pathway_Homo sapiens_hsa049170.60913840
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60408123
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59511644
96Other glycan degradation_Homo sapiens_hsa005110.58858446
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.58470038
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.57949139
99Apoptosis_Homo sapiens_hsa042100.56639437
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.56072098
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56000557
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55677285
103African trypanosomiasis_Homo sapiens_hsa051430.55597928
104Salmonella infection_Homo sapiens_hsa051320.55357635
105mTOR signaling pathway_Homo sapiens_hsa041500.54159567
106Fructose and mannose metabolism_Homo sapiens_hsa000510.53312529
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53199551
108Small cell lung cancer_Homo sapiens_hsa052220.53194938
109Toxoplasmosis_Homo sapiens_hsa051450.53060610
110Type II diabetes mellitus_Homo sapiens_hsa049300.52967258
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51610294
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49727400
113Pyruvate metabolism_Homo sapiens_hsa006200.48040445
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47943255
115Estrogen signaling pathway_Homo sapiens_hsa049150.47465180
116Histidine metabolism_Homo sapiens_hsa003400.47301445
117Adherens junction_Homo sapiens_hsa045200.46347614
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45908793
119Hepatitis B_Homo sapiens_hsa051610.45726212
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45570538
121HIF-1 signaling pathway_Homo sapiens_hsa040660.44765901
122Phagosome_Homo sapiens_hsa041450.44595001
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.44590458
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43500296
125Inositol phosphate metabolism_Homo sapiens_hsa005620.41984702
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39300686
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38701621
128Ovarian steroidogenesis_Homo sapiens_hsa049130.34135660
129Synaptic vesicle cycle_Homo sapiens_hsa047210.33717012
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32694865
131Prostate cancer_Homo sapiens_hsa052150.29463129
132Fatty acid elongation_Homo sapiens_hsa000620.29304186
133TGF-beta signaling pathway_Homo sapiens_hsa043500.28680525
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28353171
135FoxO signaling pathway_Homo sapiens_hsa040680.26494384
136Choline metabolism in cancer_Homo sapiens_hsa052310.25056876

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