SLC12A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)9.35196598
2response to parathyroid hormone (GO:0071107)9.07754635
3lysine metabolic process (GO:0006553)8.91112331
4lysine catabolic process (GO:0006554)8.91112331
5drug transmembrane transport (GO:0006855)8.90295998
6cardiovascular system development (GO:0072358)8.70043355
7response to mercury ion (GO:0046689)8.46440479
8aminoglycoside antibiotic metabolic process (GO:0030647)8.44306519
9renal absorption (GO:0070293)7.82159575
10* excretion (GO:0007588)7.73213752
11organic cation transport (GO:0015695)7.66698827
12drug transport (GO:0015893)7.64782779
13polyol transport (GO:0015791)7.50811427
14phosphate ion transport (GO:0006817)7.35059327
15metanephric nephron tubule development (GO:0072234)7.22743329
16metanephric tubule development (GO:0072170)7.22743329
17metanephric nephron epithelium development (GO:0072243)6.63810120
18positive regulation of catenin import into nucleus (GO:0035413)6.53320657
19response to lead ion (GO:0010288)6.49315837
20positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc6.37639433
21activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)6.31837106
22phosphate ion transmembrane transport (GO:0035435)6.29977148
23positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)6.29490159
24metanephric epithelium development (GO:0072207)6.11335621
25quaternary ammonium group transport (GO:0015697)6.10665484
26cysteine metabolic process (GO:0006534)6.05567626
27aspartate family amino acid catabolic process (GO:0009068)5.97458968
28glyoxylate metabolic process (GO:0046487)5.83743685
29negative regulation of cholesterol transport (GO:0032375)5.68231269
30negative regulation of sterol transport (GO:0032372)5.68231269
31mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)5.65691422
32tricarboxylic acid metabolic process (GO:0072350)5.64770144
33response to thyroid hormone (GO:0097066)5.59915796
34regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)5.59173944
35negative regulation of metanephros development (GO:0072217)5.35925717
362-oxoglutarate metabolic process (GO:0006103)5.25888448
37nephron tubule development (GO:0072080)5.24301229
38nephron tubule formation (GO:0072079)5.24201703
39short-chain fatty acid metabolic process (GO:0046459)5.22886376
40response to magnesium ion (GO:0032026)5.18441932
41valine metabolic process (GO:0006573)5.17257953
42branched-chain amino acid metabolic process (GO:0009081)5.11986766
43regulation of apoptotic process involved in morphogenesis (GO:1902337)5.05710342
44sodium-independent organic anion transport (GO:0043252)5.05165286
45vitamin D metabolic process (GO:0042359)5.04964351
46homocysteine metabolic process (GO:0050667)5.03449446
47nonribosomal peptide biosynthetic process (GO:0019184)5.03281848
48hyperosmotic response (GO:0006972)4.92660141
49inositol metabolic process (GO:0006020)4.88068749
50regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033394.87530849
51glomerular visceral epithelial cell development (GO:0072015)4.85707375
52response to copper ion (GO:0046688)4.84576506
53toxin transport (GO:1901998)4.84129416
54indole-containing compound catabolic process (GO:0042436)4.81579020
55indolalkylamine catabolic process (GO:0046218)4.81579020
56tryptophan catabolic process (GO:0006569)4.81579020
57drug catabolic process (GO:0042737)4.79212028
58amino-acid betaine transport (GO:0015838)4.79025168
59carnitine transport (GO:0015879)4.79025168
60collecting duct development (GO:0072044)4.70788450
61cellular response to ammonium ion (GO:0071242)4.69597205
62aromatic amino acid family catabolic process (GO:0009074)4.69251979
63renal tubule development (GO:0061326)4.65501625
64bone remodeling (GO:0046849)4.63899612
65response to vitamin A (GO:0033189)4.58184989
66glutathione biosynthetic process (GO:0006750)4.55972836
67tryptophan metabolic process (GO:0006568)4.52699987
68modified amino acid transport (GO:0072337)4.49277442
69actin filament depolymerization (GO:0030042)4.45969201
70branched-chain amino acid catabolic process (GO:0009083)4.43566421
71cellular ketone body metabolic process (GO:0046950)4.41542130
72erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.41310987
73L-phenylalanine metabolic process (GO:0006558)4.41310987
74amino-acid betaine metabolic process (GO:0006577)4.36694385
75L-phenylalanine catabolic process (GO:0006559)4.34280726
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.34280726
77phosphate ion homeostasis (GO:0055062)4.31531424
78trivalent inorganic anion homeostasis (GO:0072506)4.31531424
79negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.31337789
80nephron epithelium development (GO:0072009)4.28898884
81acetyl-CoA metabolic process (GO:0006084)4.28605923
82fatty acid beta-oxidation (GO:0006635)4.28190322
83one-carbon compound transport (GO:0019755)4.26174507
84exogenous drug catabolic process (GO:0042738)4.25725710
85glomerular epithelial cell development (GO:0072310)4.25681581
86renal system process (GO:0003014)4.25615148
87kynurenine metabolic process (GO:0070189)4.25099207
88pattern specification involved in kidney development (GO:0061004)4.23566326
89regulation of protein localization to cell surface (GO:2000008)4.21018253
90cellular modified amino acid catabolic process (GO:0042219)4.16607282
91fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.12203228
92carnitine metabolic process (GO:0009437)4.10604082
93cell volume homeostasis (GO:0006884)4.10155728
94glutamate metabolic process (GO:0006536)4.06420925
95positive regulation of peptidyl-threonine phosphorylation (GO:0010800)4.05529239
96mammary gland alveolus development (GO:0060749)4.01616057
97fatty acid oxidation (GO:0019395)3.97372120
98serine family amino acid catabolic process (GO:0009071)3.96595256
99proline metabolic process (GO:0006560)3.92558869
100serine family amino acid metabolic process (GO:0009069)3.90263375
101fructose metabolic process (GO:0006000)3.90210604
102glycoside metabolic process (GO:0016137)3.89980608
103lipid oxidation (GO:0034440)3.89972093
104ERK1 and ERK2 cascade (GO:0070371)3.89205465
105response to salt stress (GO:0009651)3.85659296
106response to phenylpropanoid (GO:0080184)3.83586649
107NADH metabolic process (GO:0006734)3.83481548
108ketone body metabolic process (GO:1902224)3.79481757
109regulation of fever generation (GO:0031620)3.76995847
110regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:23.75601925
111protein depolymerization (GO:0051261)3.73387253
112beta-amyloid metabolic process (GO:0050435)3.69658455
113positive regulation of heat generation (GO:0031652)3.65371262
114peptide biosynthetic process (GO:0043043)3.61562101
115cell differentiation involved in metanephros development (GO:0072202)3.61426296
116tricarboxylic acid cycle (GO:0006099)3.58734779
117regulation of potassium ion transmembrane transporter activity (GO:1901016)3.57040972
118S-adenosylmethionine metabolic process (GO:0046500)3.54591283
119fatty acid catabolic process (GO:0009062)3.50933925
120regulation of cholesterol efflux (GO:0010874)3.49997006
121cellular amino acid catabolic process (GO:0009063)3.49096800
122nephron tubule morphogenesis (GO:0072078)3.48316901
123nephron epithelium morphogenesis (GO:0072088)3.48316901
124response to water (GO:0009415)3.45909370
125regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.45685386
126transepithelial transport (GO:0070633)3.45020284
127peptide catabolic process (GO:0043171)3.43716144
128vitamin transport (GO:0051180)3.43094331
129aromatic amino acid family metabolic process (GO:0009072)3.42987979
130biotin metabolic process (GO:0006768)3.41838611
131response to growth hormone (GO:0060416)3.41097965
132L-methionine salvage (GO:0071267)3.40438113
133L-methionine biosynthetic process (GO:0071265)3.40438113
134amino acid salvage (GO:0043102)3.40438113
135alpha-amino acid catabolic process (GO:1901606)3.39647544
136urogenital system development (GO:0001655)3.38154333
137succinate metabolic process (GO:0006105)3.36731867
138positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)3.35608921
139indole-containing compound metabolic process (GO:0042430)3.34859298
140indolalkylamine metabolic process (GO:0006586)3.34554212
141oxaloacetate metabolic process (GO:0006107)3.33902325
142mesonephros development (GO:0001823)3.30119525
143hyperosmotic salinity response (GO:0042538)3.27831611
144monocarboxylic acid catabolic process (GO:0072329)3.25570334
145regulation of mesenchymal cell apoptotic process (GO:2001053)3.24412946
146regulation of anion transport (GO:0044070)3.22062574
147carboxylic acid catabolic process (GO:0046395)3.20620346
148organic acid catabolic process (GO:0016054)3.20620346
149* sodium ion transport (GO:0006814)3.19913504
150positive regulation of ERBB signaling pathway (GO:1901186)3.18943446
151sulfur amino acid catabolic process (GO:0000098)3.18219111
152surfactant homeostasis (GO:0043129)3.16012360
153dicarboxylic acid metabolic process (GO:0043648)3.15960246
154response to lithium ion (GO:0010226)3.10239129
155regulation of catenin import into nucleus (GO:0035412)3.07197332
156regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.06326391
157regulation of stem cell maintenance (GO:2000036)3.03211499
158positive regulation of metanephros development (GO:0072216)3.01955322
159kidney epithelium development (GO:0072073)3.01935251
160regulation of heat generation (GO:0031650)2.98883922
161regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.95807122
162positive regulation of glomerulus development (GO:0090193)2.94453520
163negative regulation of kidney development (GO:0090185)2.92880798
164sodium ion homeostasis (GO:0055078)2.92823573
165glycine metabolic process (GO:0006544)2.86997744
166negative regulation of lipid transport (GO:0032369)2.86012151
167regulation of potassium ion transmembrane transport (GO:1901379)2.84994091
168positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.83501210
169mesenchymal to epithelial transition (GO:0060231)2.83395826
170regulation of calcium ion import (GO:0090279)2.81180664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.77464705
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.72679791
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.35975598
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.91192289
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.61400685
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.60226944
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.82163960
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.78155953
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.61506178
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.59734619
11VDR_22108803_ChIP-Seq_LS180_Human2.57475008
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.56149439
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.52580950
14CLOCK_20551151_ChIP-Seq_293T_Human2.49555189
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.49436413
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.48482470
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35953790
18AR_21909140_ChIP-Seq_LNCAP_Human2.18823343
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.09919036
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00767332
21GBX2_23144817_ChIP-Seq_PC3_Human1.94572711
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87821673
23* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.86911900
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.85306291
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.80665244
26P53_22127205_ChIP-Seq_FIBROBLAST_Human1.77168708
27EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.75650633
28RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74050919
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.72320290
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.70660580
31GATA4_25053715_ChIP-Seq_YYC3_Human1.70593862
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.68256884
33SMAD4_21799915_ChIP-Seq_A2780_Human1.64916192
34* KLF4_18555785_Chip-Seq_ESCs_Mouse1.64499371
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61177596
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.55933938
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55368112
38* E2F1_18555785_Chip-Seq_ESCs_Mouse1.55243312
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.54723143
40* NANOG_18555785_Chip-Seq_ESCs_Mouse1.54115750
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53809367
42P53_22387025_ChIP-Seq_ESCs_Mouse1.53068138
43TAF15_26573619_Chip-Seq_HEK293_Human1.48852906
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46828408
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.40375638
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39800069
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.39079611
48LXR_22292898_ChIP-Seq_THP-1_Human1.38752017
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38304705
50EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.37362251
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.36494365
52DROSHA_22980978_ChIP-Seq_HELA_Human1.36142509
53TCF4_22108803_ChIP-Seq_LS180_Human1.36123173
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35519210
55STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35160968
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34410093
57* OCT4_18555785_Chip-Seq_ESCs_Mouse1.34026265
58EGR1_19032775_ChIP-ChIP_M12_Human1.33530286
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33488481
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.33187183
61CBP_21632823_ChIP-Seq_H3396_Human1.31922108
62RACK7_27058665_Chip-Seq_MCF-7_Human1.31664211
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31267551
64* STAT3_18555785_Chip-Seq_ESCs_Mouse1.30993299
65GATA1_22025678_ChIP-Seq_K562_Human1.30469776
66CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29886978
67* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29785045
68GATA6_25053715_ChIP-Seq_YYC3_Human1.29700059
69RXR_22108803_ChIP-Seq_LS180_Human1.29046585
70SMAD3_21741376_ChIP-Seq_HESCs_Human1.28137289
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27279907
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27187207
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.26691681
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23616631
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.23480842
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.23480842
77* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22956807
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22563483
79* P300_18555785_Chip-Seq_ESCs_Mouse1.22548827
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.20781041
81KDM2B_26808549_Chip-Seq_REH_Human1.19862787
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19503973
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19380838
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.18619951
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17613240
86TBL1_22424771_ChIP-Seq_293T_Human1.17543350
87SOX2_20726797_ChIP-Seq_SW620_Human1.17305732
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16899015
89PHF8_20622853_ChIP-Seq_HELA_Human1.14650853
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14464254
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.13266862
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11713167
93SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11289009
94BCAT_22108803_ChIP-Seq_LS180_Human1.10942400
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.10896605
96NFYA_21822215_ChIP-Seq_K562_Human1.10429148
97* ZFX_18555785_Chip-Seq_ESCs_Mouse1.10353832
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10088938
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.09929456
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.08477812
101SMAD1_18555785_Chip-Seq_ESCs_Mouse1.08309646
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.07941896
103CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07675882
104HTT_18923047_ChIP-ChIP_STHdh_Human1.06571041
105PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05991367
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05682649
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04845696
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04071758
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02855183
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01945677
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01854030
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00611908
113* SOX2_18555785_Chip-Seq_ESCs_Mouse1.00219718
114ETV1_20927104_ChIP-Seq_GIST48_Human0.99689627
115VDR_24787735_ChIP-Seq_THP-1_Human0.98938520
116* PU1_27457419_Chip-Seq_LIVER_Mouse0.98548697
117* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98312725
118CTCF_18555785_Chip-Seq_ESCs_Mouse0.97684208
119P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.97637722
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.96934754
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96892769
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96756656
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96428623
124EZH2_27294783_Chip-Seq_ESCs_Mouse0.96049614
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95448977
126CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95273282
127FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94878282
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92933543
129SOX11_22085726_ChIP-Seq_ESNs_Mouse0.92813138
130* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90998570
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88735895
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87903204
133FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87048697
134GATA2_19941826_ChIP-Seq_K562_Human0.86423617
135NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85684460
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85439176
137TP63_23658742_ChIP-Seq_EP156T_Human0.83478898
138MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83364618
139* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82784807
140GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82609461
141CDX2_22108803_ChIP-Seq_LS180_Human0.81350049
142TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81178050
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.80973569
144CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79891258
145CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78968101
146CREB1_26743006_Chip-Seq_LNCaP_Human0.78079714
147RAD21_21589869_ChIP-Seq_MESCs_Mouse0.77767808
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76293013
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76293013
150SMC4_20622854_ChIP-Seq_HELA_Human0.75951092
151GATA1_19941826_ChIP-Seq_K562_Human0.75804362
152RAC3_21632823_ChIP-Seq_H3396_Human0.75718879
153WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75613903
154AHR_22903824_ChIP-Seq_MCF-7_Human0.75282689
155ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74326818
156IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.72552160
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.71507976
158EOMES_21245162_ChIP-Seq_HESCs_Human0.71120140
159GATA1_19941827_ChIP-Seq_MEL86_Mouse0.71097983
160EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.70350622
161SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.70192204
162CTCF_27219007_Chip-Seq_Bcells_Human0.69556391
163RUNX1_27514584_Chip-Seq_MCF-7_Human0.69082674

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.55816689
2* MP0004043_abnormal_pH_regulation7.01484841
3* MP0005332_abnormal_amino_acid4.74230538
4MP0004019_abnormal_vitamin_homeostasis4.68417100
5* MP0001756_abnormal_urination4.49760926
6* MP0009643_abnormal_urine_homeostasis4.37284535
7* MP0001765_abnormal_ion_homeostasis3.97187350
8MP0002138_abnormal_hepatobiliary_system3.87834958
9MP0002139_abnormal_hepatobiliary_system3.86735790
10* MP0002136_abnormal_kidney_physiology3.37572098
11* MP0005636_abnormal_mineral_homeostasis3.17203925
12MP0005377_hearing/vestibular/ear_phenot2.85438526
13MP0003878_abnormal_ear_physiology2.85438526
14MP0003252_abnormal_bile_duct2.66087830
15MP0008875_abnormal_xenobiotic_pharmacok2.58048092
16MP0001958_emphysema2.52736014
17MP0008961_abnormal_basal_metabolism2.51078998
18MP0004885_abnormal_endolymph2.34676212
19MP0000538_abnormal_urinary_bladder2.32353277
20MP0005365_abnormal_bile_salt2.10887233
21MP0005085_abnormal_gallbladder_physiolo1.93774509
22MP0005058_abnormal_lysosome_morphology1.76723135
23MP0003045_fibrosis1.72286881
24MP0005451_abnormal_body_composition1.56341970
25MP0003300_gastrointestinal_ulcer1.55616401
26MP0003186_abnormal_redox_activity1.54501896
27MP0003283_abnormal_digestive_organ1.45435026
28MP0002928_abnormal_bile_duct1.34635670
29* MP0005584_abnormal_enzyme/coenzyme_acti1.32305653
30MP0002876_abnormal_thyroid_physiology1.29414253
31MP0006036_abnormal_mitochondrial_physio1.28671409
32* MP0002135_abnormal_kidney_morphology1.27144962
33MP0010234_abnormal_vibrissa_follicle1.26109197
34MP0005535_abnormal_body_temperature1.22668904
35* MP0000230_abnormal_systemic_arterial1.20244142
36MP0009672_abnormal_birth_weight1.18845540
37MP0003183_abnormal_peptide_metabolism1.17054295
38MP0005084_abnormal_gallbladder_morpholo1.16794413
39* MP0003195_calcinosis1.14052126
40MP0003806_abnormal_nucleotide_metabolis1.13557715
41MP0001764_abnormal_homeostasis1.09176099
42MP0003191_abnormal_cellular_cholesterol1.07178792
43* MP0005319_abnormal_enzyme/_coenzyme1.04085759
44MP0000534_abnormal_ureter_morphology1.02616186
45MP0003646_muscle_fatigue0.96016437
46MP0005666_abnormal_adipose_tissue0.94188058
47MP0004264_abnormal_extraembryonic_tissu0.93768400
48MP0001666_abnormal_nutrient_absorption0.93096402
49MP0002896_abnormal_bone_mineralization0.92968520
50MP0003638_abnormal_response/metabolism_0.92407489
51MP0003943_abnormal_hepatobiliary_system0.92248380
52MP0003959_abnormal_lean_body0.89412645
53MP0005670_abnormal_white_adipose0.87455845
54MP0002118_abnormal_lipid_homeostasis0.85235044
55MP0001661_extended_life_span0.84044300
56MP0005220_abnormal_exocrine_pancreas0.81699397
57MP0004147_increased_porphyrin_level0.78583281
58* MP0002168_other_aberrant_phenotype0.78161417
59MP0003941_abnormal_skin_development0.76598134
60* MP0009642_abnormal_blood_homeostasis0.76233726
61MP0001270_distended_abdomen0.74806712
62MP0002089_abnormal_postnatal_growth/wei0.73575610
63MP0003938_abnormal_ear_development0.71471662
64MP0004742_abnormal_vestibular_system0.69756888
65MP0004272_abnormal_basement_membrane0.67279042
66MP0002971_abnormal_brown_adipose0.66246508
67MP0010386_abnormal_urinary_bladder0.63952451
68MP0002796_impaired_skin_barrier0.63553367
69MP0010329_abnormal_lipoprotein_level0.60170812
70MP0000609_abnormal_liver_physiology0.57815980
71MP0009764_decreased_sensitivity_to0.57509095
72MP0003315_abnormal_perineum_morphology0.57360677
73MP0000747_muscle_weakness0.57002822
74MP0009703_decreased_birth_body0.56648469
75MP0003172_abnormal_lysosome_physiology0.55891784
76MP0005165_increased_susceptibility_to0.55590565
77MP0003329_amyloid_beta_deposits0.53169104
78MP0008004_abnormal_stomach_pH0.50738571
79MP0004233_abnormal_muscle_weight0.50350334
80* MP0002069_abnormal_eating/drinking_beha0.49838622
81MP0001944_abnormal_pancreas_morphology0.49120749
82MP0000026_abnormal_inner_ear0.47950071
83MP0001485_abnormal_pinna_reflex0.46659397
84MP0006035_abnormal_mitochondrial_morpho0.45555298
85MP0004484_altered_response_of0.45224013
86MP0000371_diluted_coat_color0.44866732
87MP0001177_atelectasis0.44400072
88MP0005375_adipose_tissue_phenotype0.42628441
89MP0004858_abnormal_nervous_system0.42514961
90MP0000598_abnormal_liver_morphology0.42025165
91MP0003879_abnormal_hair_cell0.41969211
92* MP0002078_abnormal_glucose_homeostasis0.41944350
93MP0005501_abnormal_skin_physiology0.41882932
94MP0002108_abnormal_muscle_morphology0.40590487
95MP0003221_abnormal_cardiomyocyte_apopto0.40434479
96MP0002098_abnormal_vibrissa_morphology0.40369732
97MP0000631_abnormal_neuroendocrine_gland0.40089769
98MP0003724_increased_susceptibility_to0.39423305
99MP0002998_abnormal_bone_remodeling0.39400760
100MP0002115_abnormal_skeleton_extremities0.38878786
101* MP0008469_abnormal_protein_level0.38721517
102MP0005167_abnormal_blood-brain_barrier0.37797368
103* MP0005395_other_phenotype0.37740956
104MP0005408_hypopigmentation0.37459345
105* MP0003953_abnormal_hormone_level0.36443682
106MP0001963_abnormal_hearing_physiology0.36361689
107* MP0003795_abnormal_bone_structure0.35759859
108MP0000751_myopathy0.35010516
109MP0003075_altered_response_to0.34996143
110* MP0001191_abnormal_skin_condition0.34608053
111MP0008775_abnormal_heart_ventricle0.34462132
112MP0002972_abnormal_cardiac_muscle0.33693260
113* MP0001731_abnormal_postnatal_growth0.33086534
114MP0001664_abnormal_digestion0.31764773
115MP0010368_abnormal_lymphatic_system0.31627581
116MP0001727_abnormal_embryo_implantation0.31584676
117MP0003942_abnormal_urinary_system0.31425775
118MP0008874_decreased_physiological_sensi0.29733761
119MP0008872_abnormal_physiological_respon0.29704295
120MP0003011_delayed_dark_adaptation0.27119157
121MP0004215_abnormal_myocardial_fiber0.26328333
122MP0000163_abnormal_cartilage_morphology0.20851277
123* MP0010770_preweaning_lethality0.19620372
124* MP0002082_postnatal_lethality0.19620372
125MP0005388_respiratory_system_phenotype0.18911587
126MP0002133_abnormal_respiratory_system0.18911587
127MP0001486_abnormal_startle_reflex0.18564899
128MP0005452_abnormal_adipose_tissue0.18032388
129MP0000681_abnormal_thyroid_gland0.17845847
130MP0005409_darkened_coat_color0.16631447
131MP0003137_abnormal_impulse_conducting0.15045219
132* MP0010769_abnormal_survival0.13947137
133MP0004130_abnormal_muscle_cell0.12874769
134MP0003303_peritoneal_inflammation0.12855873
135MP0000013_abnormal_adipose_tissue0.12074559
136* MP0010768_mortality/aging0.11569108
137MP0000367_abnormal_coat/_hair0.10848946
138* MP0001784_abnormal_fluid_regulation0.10777207

Predicted human phenotypes

RankGene SetZ-score
1* Metabolic alkalosis (HP:0200114)9.22623398
2* Hypokalemic alkalosis (HP:0001949)8.91185070
3* Polyuria (HP:0000103)8.02698091
4* Increased circulating renin level (HP:0000848)7.65314225
5* Abnormality of chloride homeostasis (HP:0011422)7.57222140
6* Hypomagnesemia (HP:0002917)7.51851562
7* Abnormal urine output (HP:0012590)7.48800702
8Polydipsia (HP:0001959)7.08785574
9Abnormal drinking behavior (HP:0030082)7.08785574
10* Abnormality of renal excretion (HP:0011036)6.81517470
11Gout (HP:0001997)6.75564602
12* Hyperactive renin-angiotensin system (HP:0000841)6.63928441
13* Abnormality of magnesium homeostasis (HP:0004921)6.28651928
14* Renal salt wasting (HP:0000127)5.92002181
15* Hyperaldosteronism (HP:0000859)5.80075401
16* Alkalosis (HP:0001948)5.31484505
17Hyperuricemia (HP:0002149)4.97454618
18Increased purine levels (HP:0004368)4.97454618
19* Abnormality of renin-angiotensin system (HP:0000847)4.84754308
20* Tetany (HP:0001281)4.82346618
21Proximal tubulopathy (HP:0000114)4.52438952
22Hyperglycinuria (HP:0003108)4.27932815
23* Hypokalemia (HP:0002900)4.23337280
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.06547478
25Abnormality of purine metabolism (HP:0004352)4.06238458
26Abnormality of sodium homeostasis (HP:0010931)3.90047414
27Ketoacidosis (HP:0001993)3.57584730
28* Abnormality of potassium homeostasis (HP:0011042)3.52117697
29Abnormality of glycine metabolism (HP:0010895)3.51598922
30Abnormality of serine family amino acid metabolism (HP:0010894)3.51598922
31Hyponatremia (HP:0002902)3.46591628
32* Hypercalciuria (HP:0002150)3.42371568
33Renal tubular acidosis (HP:0001947)3.40712537
34Generalized aminoaciduria (HP:0002909)3.16741313
35Ketosis (HP:0001946)2.96303076
36Abnormality of urine glucose concentration (HP:0011016)2.89988911
37Glycosuria (HP:0003076)2.89988911
38Abnormality of nucleobase metabolism (HP:0010932)2.87701995
39* Adrenal overactivity (HP:0002717)2.65094531
40Abnormality of proline metabolism (HP:0010907)2.58917044
41Hydroxyprolinuria (HP:0003080)2.58917044
42* Abnormality of fatty-acid metabolism (HP:0004359)2.57508755
43* Dehydration (HP:0001944)2.54149569
44* Nephrocalcinosis (HP:0000121)2.53443343
45Hyperphosphaturia (HP:0003109)2.51992805
46Tubulointerstitial fibrosis (HP:0005576)2.42041674
47Hyperglycinemia (HP:0002154)2.40941852
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39860217
49Abnormal urine phosphate concentration (HP:0012599)2.39825944
50Nephrolithiasis (HP:0000787)2.37392853
51Tubular atrophy (HP:0000092)2.37279019
52Decreased circulating renin level (HP:0003351)2.34732109
53Facial shape deformation (HP:0011334)2.32024147
54Potter facies (HP:0002009)2.32024147
55Delayed CNS myelination (HP:0002188)2.31536680
56Delayed epiphyseal ossification (HP:0002663)2.27654407
57* Vomiting (HP:0002013)2.17262640
58Hyperammonemia (HP:0001987)2.13527762
59Hypophosphatemia (HP:0002148)2.10664536
60Neonatal onset (HP:0003623)2.07617308
61Renal tubular dysfunction (HP:0000124)2.05652248
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05502977
63Dicarboxylic aciduria (HP:0003215)2.05502977
64Metabolic acidosis (HP:0001942)2.04189692
65Enlarged kidneys (HP:0000105)2.01412403
66Focal segmental glomerulosclerosis (HP:0000097)1.99618804
67Vascular calcification (HP:0004934)1.98655770
68Rickets (HP:0002748)1.96773226
69Widely patent fontanelles and sutures (HP:0004492)1.96102426
70Vacuolated lymphocytes (HP:0001922)1.92568362
71Glomerulosclerosis (HP:0000096)1.90863732
72Metaphyseal cupping (HP:0003021)1.88338919
73Abnormality of sulfur amino acid metabolism (HP:0004339)1.87052744
74Abnormality of renal resorption (HP:0011038)1.83104842
75Bilateral sensorineural hearing impairment (HP:0008619)1.77802297
76Cardiovascular calcification (HP:0011915)1.77720675
77Abnormality of the renal medulla (HP:0100957)1.77667744
78Lethargy (HP:0001254)1.77405135
79Nephrogenic diabetes insipidus (HP:0009806)1.77259329
80Confusion (HP:0001289)1.76126869
81Irritability (HP:0000737)1.74861345
82Large eyes (HP:0001090)1.73846427
83Malnutrition (HP:0004395)1.70548194
84Abnormality of aromatic amino acid family metabolism (HP:0004338)1.69816802
85Bicornuate uterus (HP:0000813)1.67599865
86* Chondrocalcinosis (HP:0000934)1.66994721
87Methylmalonic aciduria (HP:0012120)1.66777017
88Thin bony cortex (HP:0002753)1.66562122
89Abnormality of the renal cortex (HP:0011035)1.61911233
90Hyperkalemia (HP:0002153)1.61902624
91Tubulointerstitial abnormality (HP:0001969)1.56840162
92Lymphangioma (HP:0100764)1.56760227
93Abnormal enzyme/coenzyme activity (HP:0012379)1.56185241
94* Abnormality of Sharpey fibers (HP:0100685)1.55297141
95Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.53862862
96Hypothermia (HP:0002045)1.53732921
97* Hypotension (HP:0002615)1.53048715
98Tachypnea (HP:0002789)1.52521298
99Abnormality of alkaline phosphatase activity (HP:0004379)1.51221211
100Impaired platelet aggregation (HP:0003540)1.50208270
101Abnormal platelet function (HP:0011869)1.50208270
102Nausea (HP:0002018)1.46862756
103* Generalized muscle weakness (HP:0003324)1.41910667
104Abnormal tarsal ossification (HP:0008369)1.41042186
105Metaphyseal dysplasia (HP:0100255)1.40493801
106Elevated alkaline phosphatase (HP:0003155)1.35405613
107Intellectual disability, moderate (HP:0002342)1.34932841
108Abnormality of calcium-phosphate metabolism (HP:0100530)1.30815882
109* Premature birth (HP:0001622)1.18877603
110Neonatal death (HP:0003811)1.18603129
111Thyroid-stimulating hormone excess (HP:0002925)1.08243594
112Osteomalacia (HP:0002749)1.06403543
113* Osteopenia (HP:0000938)1.05194684
114Persistence of primary teeth (HP:0006335)1.04577417
115* Paresthesia (HP:0003401)0.99550998
116Hypophosphatemic rickets (HP:0004912)0.97017187
117Enlarged epiphyses (HP:0010580)0.96634075
118Abnormality of the fingertips (HP:0001211)0.96064504
119Abnormality of macular pigmentation (HP:0008002)0.93875684
120Hyperphosphatemia (HP:0002905)0.89318819
121Esophageal varix (HP:0002040)0.88780907
122* Polyhydramnios (HP:0001561)0.86404297
123Pancreatic cysts (HP:0001737)0.84976430
124Stage 5 chronic kidney disease (HP:0003774)0.82483539
125Abnormal foot bone ossification (HP:0010675)0.80213912
126Amelogenesis imperfecta (HP:0000705)0.79180275
127Choanal stenosis (HP:0000452)0.77159933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.12388685
2* OXSR14.67276131
3BCKDK3.39158184
4SGK2233.02387634
5SGK4943.02387634
6WNK12.75182290
7STK38L2.72943091
8PDK32.52362475
9PDK42.52362475
10SGK22.49361915
11NEK12.14269407
12SGK32.13910953
13WNK411.2899656
14PDK21.97476382
15MST41.45936483
16MST1R1.45723809
17STK381.44270868
18LRRK21.18882199
19TIE11.12296710
20PIK3CG1.00280858
21SGK10.93110482
22FGFR40.91515352
23PINK10.89504493
24EPHB10.87707867
25GSK3A0.81487617
26TGFBR20.74895766
27ERN10.68817772
28MAP3K70.68038607
29GRK60.65708963
30PAK40.64365784
31PTK60.62691630
32PTK20.62226716
33MAP3K30.61979830
34AKT30.58316442
35NLK0.57817266
36MAPK150.53582162
37PDPK10.53102626
38PAK30.52990399
39PRKD20.51774432
40DYRK1B0.51751299
41FER0.49308311
42TRIB30.48735057
43ABL20.48059769
44MET0.45302633
45PRKAA20.43879936
46INSRR0.40952408
47STK100.40784880
48NTRK10.38938688
49PRKCI0.38861583
50MAPK110.38426581
51PDK10.37114087
52EPHA30.36788831
53PRKCH0.36508730
54FGFR30.35999599
55PRKCZ0.35255584
56PRKCD0.35125591
57PTK2B0.34816828
58RIPK10.34753023
59MAP3K20.34085480
60BRSK20.34076736
61YES10.33813522
62PRKACG0.31239234
63MYLK0.30269819
64CSNK1A10.27125854
65RET0.25437986
66MINK10.24771518
67LATS10.24566341
68CAMKK20.23338065
69PRKACA0.23275820
70BMX0.23143408
71JAK20.22224228
72AKT20.21930972
73SCYL20.20609203
74PRKCB0.20205616
75PRKCA0.19416160
76ERBB40.18921643
77GRK10.18169569
78FGFR20.18123006
79STK110.17780506
80MAP3K140.16835395
81MAP3K10.15727317
82FRK0.15188230
83IRAK40.15127501
84TYK20.14922672
85MAP2K30.14408670
86RAF10.14253575
87IRAK20.14239312
88PDGFRA0.14032746
89CSNK1A1L0.13641879
90* PRKAA10.13078573
91ACVR1B0.13025563
92ROCK10.12690031
93STK30.12374278
94MAP3K120.11958129
95SRC0.11893625
96PRKD30.11802808
97BTK0.11650264
98NTRK30.10826386
99DAPK20.10431499
100BCR0.10393448
101MAP3K110.10277001
102JAK10.10214526
103EPHA40.09879317
104EPHB20.09801753
105PKN20.08731443
106PIM10.08626035
107INSR0.07962006
108RPS6KA30.07685792
109MAP2K40.07569490
110MAPK120.06993372
111MARK30.06876229
112HCK0.06856064
113MELK0.06502959
114PRKCG0.06166247
115CSK0.05974816
116PRKCE0.05539341
117MARK20.05254584
118IGF1R0.05102679
119PRKCQ0.04970081
120MTOR0.04458936
121RIPK40.03099322
122KSR20.02798594
123KDR0.02490311
124IRAK10.02475917
125ZAP700.02167022
126ROCK20.02096592
127CDK50.02048446
128FYN0.02010120
129KSR10.01764171
130BLK0.01761438
131DMPK0.01281167
132CSF1R0.01051714
133ABL10.00373753
134PRKD10.00272264
135TGFBR10.00230903
136SIK10.00184199
137MAP3K60.00169233
138ERBB2-0.0051793
139TEC-0.0022578

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049644.01283907
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.59584185
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.52655036
4Butanoate metabolism_Homo sapiens_hsa006503.46052165
5Propanoate metabolism_Homo sapiens_hsa006403.32735944
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.32320385
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.24389777
8Cyanoamino acid metabolism_Homo sapiens_hsa004603.07144526
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.83144161
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.64790673
11Fatty acid degradation_Homo sapiens_hsa000712.39244920
12Collecting duct acid secretion_Homo sapiens_hsa049662.28715679
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28161462
14Peroxisome_Homo sapiens_hsa041462.27509843
15Pyruvate metabolism_Homo sapiens_hsa006202.22206437
16Tryptophan metabolism_Homo sapiens_hsa003802.17319328
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08982443
18Vitamin digestion and absorption_Homo sapiens_hsa049772.04343716
19Bile secretion_Homo sapiens_hsa049761.90328003
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.87338140
21Sulfur metabolism_Homo sapiens_hsa009201.83681992
22Carbon metabolism_Homo sapiens_hsa012001.80451733
23Fatty acid metabolism_Homo sapiens_hsa012121.76117083
24Endometrial cancer_Homo sapiens_hsa052131.75567865
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.74418063
26beta-Alanine metabolism_Homo sapiens_hsa004101.73752299
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65529619
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64319959
29Non-small cell lung cancer_Homo sapiens_hsa052231.63951689
30Glutathione metabolism_Homo sapiens_hsa004801.48206577
31Pancreatic cancer_Homo sapiens_hsa052121.42430789
32Protein digestion and absorption_Homo sapiens_hsa049741.42035574
33Mineral absorption_Homo sapiens_hsa049781.38245641
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36825551
35Lysine degradation_Homo sapiens_hsa003101.31929084
36Arginine biosynthesis_Homo sapiens_hsa002201.27157986
37PPAR signaling pathway_Homo sapiens_hsa033201.25278807
38Nitrogen metabolism_Homo sapiens_hsa009101.23385717
39Glioma_Homo sapiens_hsa052141.19828091
40Arginine and proline metabolism_Homo sapiens_hsa003301.17158523
41Biosynthesis of amino acids_Homo sapiens_hsa012301.16619341
42Other glycan degradation_Homo sapiens_hsa005111.14798669
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12674165
44Melanoma_Homo sapiens_hsa052181.12094501
45Oxidative phosphorylation_Homo sapiens_hsa001901.04114392
46FoxO signaling pathway_Homo sapiens_hsa040681.02519840
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02478829
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97839240
49Selenocompound metabolism_Homo sapiens_hsa004500.94300439
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91332533
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.87583722
52Prostate cancer_Homo sapiens_hsa052150.85738120
53Starch and sucrose metabolism_Homo sapiens_hsa005000.83760422
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83636880
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81682167
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.80726461
57ErbB signaling pathway_Homo sapiens_hsa040120.80068124
58Phenylalanine metabolism_Homo sapiens_hsa003600.78972410
59Fructose and mannose metabolism_Homo sapiens_hsa000510.76939922
60Fatty acid elongation_Homo sapiens_hsa000620.76806285
61Renin-angiotensin system_Homo sapiens_hsa046140.76798401
62Gap junction_Homo sapiens_hsa045400.76190574
63Gastric acid secretion_Homo sapiens_hsa049710.75610055
64Glycerolipid metabolism_Homo sapiens_hsa005610.75207332
65Folate biosynthesis_Homo sapiens_hsa007900.72687348
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71668159
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69498183
68Histidine metabolism_Homo sapiens_hsa003400.69347728
69Thyroid hormone synthesis_Homo sapiens_hsa049180.66288570
70Parkinsons disease_Homo sapiens_hsa050120.65433616
71Lysosome_Homo sapiens_hsa041420.64151672
72HIF-1 signaling pathway_Homo sapiens_hsa040660.58718711
73Pentose phosphate pathway_Homo sapiens_hsa000300.53109330
74Vitamin B6 metabolism_Homo sapiens_hsa007500.53043381
75Thyroid cancer_Homo sapiens_hsa052160.51499023
76Metabolic pathways_Homo sapiens_hsa011000.48971250
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47117256
78Chemical carcinogenesis_Homo sapiens_hsa052040.46792956
79Complement and coagulation cascades_Homo sapiens_hsa046100.43451624
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41024647
81Cardiac muscle contraction_Homo sapiens_hsa042600.40961344
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.40593389
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.38501772
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38381586
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.38242235
86Vibrio cholerae infection_Homo sapiens_hsa051100.38153256
87Focal adhesion_Homo sapiens_hsa045100.37819983
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.36207837
89Dorso-ventral axis formation_Homo sapiens_hsa043200.34911347
90Alzheimers disease_Homo sapiens_hsa050100.33734237
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31249323
92ABC transporters_Homo sapiens_hsa020100.30279577
93Rap1 signaling pathway_Homo sapiens_hsa040150.29509128
94Synaptic vesicle cycle_Homo sapiens_hsa047210.27274764
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26014602
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23310561
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.22122619
98Retinol metabolism_Homo sapiens_hsa008300.21509408
99Tyrosine metabolism_Homo sapiens_hsa003500.21409962
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20739734
101Circadian rhythm_Homo sapiens_hsa047100.19553675
102Choline metabolism in cancer_Homo sapiens_hsa052310.17710078
103Pathways in cancer_Homo sapiens_hsa052000.16886152
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16836062
105Huntingtons disease_Homo sapiens_hsa050160.16596946
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.12881505
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12772198
108Insulin resistance_Homo sapiens_hsa049310.12027548
109Bladder cancer_Homo sapiens_hsa052190.11565465
110Arachidonic acid metabolism_Homo sapiens_hsa005900.10785206
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10656281
112Sulfur relay system_Homo sapiens_hsa041220.09417500
113Sphingolipid metabolism_Homo sapiens_hsa006000.08887803
114Renin secretion_Homo sapiens_hsa049240.08322723
115Endocytosis_Homo sapiens_hsa041440.08151347
116Ras signaling pathway_Homo sapiens_hsa040140.07340485
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.06544046
118Rheumatoid arthritis_Homo sapiens_hsa053230.05744153
119Hepatitis C_Homo sapiens_hsa051600.05517487
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.04932973
121Galactose metabolism_Homo sapiens_hsa000520.04008010
122MAPK signaling pathway_Homo sapiens_hsa040100.03959185
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.03698142
124Inositol phosphate metabolism_Homo sapiens_hsa005620.03513846
125AMPK signaling pathway_Homo sapiens_hsa041520.02863509
126cAMP signaling pathway_Homo sapiens_hsa040240.01585913
127Glucagon signaling pathway_Homo sapiens_hsa049220.00845971
128Tight junction_Homo sapiens_hsa045300.00714455
129Steroid biosynthesis_Homo sapiens_hsa00100-0.0466032
130ECM-receptor interaction_Homo sapiens_hsa04512-0.0428220
131Pancreatic secretion_Homo sapiens_hsa04972-0.0331070

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