SLC12A3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)9.72064309
2drug transmembrane transport (GO:0006855)9.42312385
3phosphate ion transport (GO:0006817)7.82026975
4drug transport (GO:0015893)7.79710432
5lysine metabolic process (GO:0006553)7.53003317
6lysine catabolic process (GO:0006554)7.53003317
7organic cation transport (GO:0015695)7.35771275
8renal absorption (GO:0070293)6.93997368
9excretion (GO:0007588)6.93965668
10drug catabolic process (GO:0042737)6.51861537
11quaternary ammonium group transport (GO:0015697)6.46309488
12phosphate ion transmembrane transport (GO:0035435)6.26889736
13exogenous drug catabolic process (GO:0042738)6.22659949
14response to mercury ion (GO:0046689)6.12924146
15metanephric tubule development (GO:0072170)5.96833501
16metanephric nephron tubule development (GO:0072234)5.96833501
17glyoxylate metabolic process (GO:0046487)5.90771138
18tricarboxylic acid metabolic process (GO:0072350)5.71851412
19metanephric nephron epithelium development (GO:0072243)5.63903578
20vitamin D metabolic process (GO:0042359)5.55070105
21metanephric epithelium development (GO:0072207)5.51643575
22cysteine metabolic process (GO:0006534)5.28409016
23short-chain fatty acid metabolic process (GO:0046459)5.09178131
24aspartate family amino acid catabolic process (GO:0009068)5.01972868
25toxin transport (GO:1901998)4.91907234
26glomerular basement membrane development (GO:0032836)4.89064886
27homocysteine metabolic process (GO:0050667)4.82385705
28carnitine transport (GO:0015879)4.79690096
29amino-acid betaine transport (GO:0015838)4.79690096
30phosphate ion homeostasis (GO:0055062)4.70580793
31trivalent inorganic anion homeostasis (GO:0072506)4.70580793
32nonribosomal peptide biosynthetic process (GO:0019184)4.65723027
33cAMP catabolic process (GO:0006198)4.54395551
34branched-chain amino acid metabolic process (GO:0009081)4.47615341
35valine metabolic process (GO:0006573)4.45508326
36nephron tubule development (GO:0072080)4.44254846
37modified amino acid transport (GO:0072337)4.40392637
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.34917615
39L-phenylalanine metabolic process (GO:0006558)4.34917615
40erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.34047727
41L-phenylalanine catabolic process (GO:0006559)4.34047727
42glycoside metabolic process (GO:0016137)4.23320449
43nephron epithelium morphogenesis (GO:0072088)4.21019323
44nephron tubule morphogenesis (GO:0072078)4.21019323
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.16140777
46S-adenosylmethionine metabolic process (GO:0046500)4.13849255
47glutathione biosynthetic process (GO:0006750)4.11708016
48aromatic amino acid family catabolic process (GO:0009074)4.01762583
49basic amino acid transport (GO:0015802)3.97971062
50cellular modified amino acid catabolic process (GO:0042219)3.96057128
51cornea development in camera-type eye (GO:0061303)3.95333714
52cyclic nucleotide catabolic process (GO:0009214)3.93751027
53renal tubule development (GO:0061326)3.93612760
54fatty acid beta-oxidation (GO:0006635)3.93512061
55glomerular visceral epithelial cell development (GO:0072015)3.93477848
56prenylation (GO:0097354)3.92119990
57protein prenylation (GO:0018342)3.92119990
58amino-acid betaine metabolic process (GO:0006577)3.91331546
59response to parathyroid hormone (GO:0071107)3.88668309
60nephron epithelium development (GO:0072009)3.88575395
612-oxoglutarate metabolic process (GO:0006103)3.87869808
62serine family amino acid catabolic process (GO:0009071)3.86853280
63proline metabolic process (GO:0006560)3.84994293
64water-soluble vitamin biosynthetic process (GO:0042364)3.82500238
65DNA deamination (GO:0045006)3.79475565
66cellular response to vitamin D (GO:0071305)3.79419472
67serine family amino acid metabolic process (GO:0009069)3.75474876
68L-fucose catabolic process (GO:0042355)3.75339804
69fucose catabolic process (GO:0019317)3.75339804
70L-fucose metabolic process (GO:0042354)3.75339804
71surfactant homeostasis (GO:0043129)3.73045831
72fructose metabolic process (GO:0006000)3.72475332
73branched-chain amino acid catabolic process (GO:0009083)3.70005904
74acetyl-CoA metabolic process (GO:0006084)3.69770156
75regulation of hippo signaling (GO:0035330)3.68507280
76behavioral response to nicotine (GO:0035095)3.67575740
77ATP hydrolysis coupled proton transport (GO:0015991)3.66238205
78energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.66238205
79indole-containing compound catabolic process (GO:0042436)3.64664357
80indolalkylamine catabolic process (GO:0046218)3.64664357
81tryptophan catabolic process (GO:0006569)3.64664357
82renal tubule morphogenesis (GO:0061333)3.63130829
83carnitine metabolic process (GO:0009437)3.57777370
84fatty acid oxidation (GO:0019395)3.57467775
85cellular ketone body metabolic process (GO:0046950)3.56189881
86pseudouridine synthesis (GO:0001522)3.55828731
87response to growth hormone (GO:0060416)3.53798984
88sodium-independent organic anion transport (GO:0043252)3.53212586
89NADH metabolic process (GO:0006734)3.52473674
90protein-cofactor linkage (GO:0018065)3.51161588
91tryptophan metabolic process (GO:0006568)3.50683480
92lipid oxidation (GO:0034440)3.50351078
93regulation of mitochondrial translation (GO:0070129)3.49171744
94collecting duct development (GO:0072044)3.48771138
95meiotic chromosome segregation (GO:0045132)3.42234095
96proline transport (GO:0015824)3.41999773
97glomerular epithelial cell development (GO:0072310)3.40987417
98exocrine pancreas development (GO:0031017)3.40252688
99glycine transport (GO:0015816)3.36171481
100peptide biosynthetic process (GO:0043043)3.34571734
101glutamate metabolic process (GO:0006536)3.32664226
102folic acid metabolic process (GO:0046655)3.32480498
103positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.31594937
104regulation of cellular respiration (GO:0043457)3.30483353
105inositol metabolic process (GO:0006020)3.30349373
106alanine transport (GO:0032328)3.30245924
107cardiovascular system development (GO:0072358)3.29470311
108L-methionine salvage (GO:0071267)3.25455269
109L-methionine biosynthetic process (GO:0071265)3.25455269
110amino acid salvage (GO:0043102)3.25455269
111positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.22927461
112fatty acid catabolic process (GO:0009062)3.20510358
113cellular amino acid catabolic process (GO:0009063)3.19089503
114peptide catabolic process (GO:0043171)3.17058070
115positive regulation of catenin import into nucleus (GO:0035413)3.16895837
116negative regulation of complement activation (GO:0045916)3.15577007
117negative regulation of digestive system process (GO:0060457)3.14107587
118respiratory chain complex IV assembly (GO:0008535)3.14017640
119cellular response to vitamin (GO:0071295)3.13850410
120carnitine transmembrane transport (GO:1902603)3.13671939
121regulation of centrosome duplication (GO:0010824)3.13671071
122L-alpha-amino acid transmembrane transport (GO:1902475)3.13635874
123* sodium ion transport (GO:0006814)3.13594020
124alpha-amino acid catabolic process (GO:1901606)3.13287400
125sulfur compound transport (GO:0072348)3.13021215
126vitamin transport (GO:0051180)3.08719078
127drug metabolic process (GO:0017144)3.03589274
128ketone body metabolic process (GO:1902224)3.03078190
129polyol transport (GO:0015791)3.02459484
130regulation of centriole replication (GO:0046599)3.01820759
131monocarboxylic acid catabolic process (GO:0072329)3.01163903
132response to magnesium ion (GO:0032026)3.00202200
133tricarboxylic acid cycle (GO:0006099)2.99667464
134rRNA methylation (GO:0031167)2.98010945
135response to lead ion (GO:0010288)2.97896201
136regulation of apoptotic process involved in morphogenesis (GO:1902337)2.97681466
137indole-containing compound metabolic process (GO:0042430)2.97544773
138glutathione metabolic process (GO:0006749)2.95455071
139methionine biosynthetic process (GO:0009086)2.90881469
140polyol catabolic process (GO:0046174)2.89190850
141kynurenine metabolic process (GO:0070189)2.85714753
142rRNA modification (GO:0000154)2.85273104
143trivalent inorganic cation transport (GO:0072512)2.84623686
144ferric iron transport (GO:0015682)2.84623686
145rRNA catabolic process (GO:0016075)2.84007601
146regulation of centrosome cycle (GO:0046605)2.83044764
147transferrin transport (GO:0033572)2.81482383
148heme transport (GO:0015886)2.81355256
149cytochrome complex assembly (GO:0017004)2.78436966
150negative regulation of protein activation cascade (GO:2000258)2.74207392
151sulfur amino acid biosynthetic process (GO:0000097)2.69964592
152regulation of nuclear cell cycle DNA replication (GO:0033262)2.68890777
153piRNA metabolic process (GO:0034587)2.65393370
154negative regulation of reactive oxygen species metabolic process (GO:2000378)2.65005159
155nephron tubule formation (GO:0072079)2.62721790
156nucleobase biosynthetic process (GO:0046112)2.62703220
157reciprocal DNA recombination (GO:0035825)2.62606312
158reciprocal meiotic recombination (GO:0007131)2.62606312
159detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62142994
160mitochondrial RNA metabolic process (GO:0000959)2.58078978
161cellular carbohydrate catabolic process (GO:0044275)2.57588788
162keratinocyte development (GO:0003334)2.55874351
163polarized epithelial cell differentiation (GO:0030859)2.54671109
164maturation of 5.8S rRNA (GO:0000460)2.54560014
165response to pheromone (GO:0019236)2.54070113
166auditory receptor cell stereocilium organization (GO:0060088)2.53569242
167regulation of triglyceride biosynthetic process (GO:0010866)2.51658635
168response to food (GO:0032094)2.50871501
169folic acid transport (GO:0015884)2.49203848
170hydrogen ion transmembrane transport (GO:1902600)2.46538299
171sulfur amino acid metabolic process (GO:0000096)2.46345468
172regulation of gene expression by genetic imprinting (GO:0006349)2.44445461
173arginine metabolic process (GO:0006525)2.44383852
174establishment of apical/basal cell polarity (GO:0035089)2.42289358
175detection of light stimulus involved in visual perception (GO:0050908)2.40563238
176detection of light stimulus involved in sensory perception (GO:0050962)2.40563238
177aminoglycoside antibiotic metabolic process (GO:0030647)10.1696405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.32860982
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.30164484
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.17178009
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78383363
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.65240131
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.62731620
7ZNF274_21170338_ChIP-Seq_K562_Hela3.54305247
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.46526541
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.36451039
10* LXR_22158963_ChIP-Seq_LIVER_Mouse3.12706859
11CLOCK_20551151_ChIP-Seq_293T_Human2.94583919
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.91845162
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.88260356
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.80026787
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.74585383
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71267929
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70833700
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.59493622
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.54532462
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.51479768
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50145931
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.45470753
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.38881953
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29697233
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22797033
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21223558
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20160416
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.17346730
29CDX2_20551321_ChIP-Seq_CACO-2_Human2.13338282
30FUS_26573619_Chip-Seq_HEK293_Human2.12948899
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11663298
32EWS_26573619_Chip-Seq_HEK293_Human2.10331863
33TP53_22573176_ChIP-Seq_HFKS_Human2.07291666
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.06774631
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02473973
36ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.99341744
37VDR_23849224_ChIP-Seq_CD4+_Human1.90738059
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85558013
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.81996212
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.77844197
41VDR_22108803_ChIP-Seq_LS180_Human1.74587630
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72783919
43DCP1A_22483619_ChIP-Seq_HELA_Human1.69914283
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.69532770
45AR_21909140_ChIP-Seq_LNCAP_Human1.68857106
46IRF1_19129219_ChIP-ChIP_H3396_Human1.65793941
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65176478
48AR_21572438_ChIP-Seq_LNCaP_Human1.61894510
49ELK1_19687146_ChIP-ChIP_HELA_Human1.59992272
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.59835925
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.56280270
52HOXB7_26014856_ChIP-Seq_BT474_Human1.55291414
53LXR_22292898_ChIP-Seq_THP-1_Human1.54520892
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.51943293
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.51608151
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48349126
57TAF15_26573619_Chip-Seq_HEK293_Human1.48017070
58* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47921780
59FOXP3_21729870_ChIP-Seq_TREG_Human1.46576442
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.43890326
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.43625103
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42661362
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42210116
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41128653
65MYC_18940864_ChIP-ChIP_HL60_Human1.40237583
66RXR_22108803_ChIP-Seq_LS180_Human1.39653045
67SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39365144
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39354131
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39279783
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38668716
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37858471
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36468071
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.36099318
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34733607
75GATA4_25053715_ChIP-Seq_YYC3_Human1.34690757
76P300_19829295_ChIP-Seq_ESCs_Human1.33567865
77SMAD3_21741376_ChIP-Seq_HESCs_Human1.31948982
78TCF4_22108803_ChIP-Seq_LS180_Human1.31774246
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.30287134
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.30287134
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.28538680
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28261990
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.28060673
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27782618
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27552308
86CBP_20019798_ChIP-Seq_JUKART_Human1.27552308
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27348010
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26837644
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25266958
90MYC_18555785_ChIP-Seq_MESCs_Mouse1.25021787
91ER_23166858_ChIP-Seq_MCF-7_Human1.24192367
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22823860
93MYC_19829295_ChIP-Seq_ESCs_Human1.22020737
94BCAT_22108803_ChIP-Seq_LS180_Human1.21901962
95PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20948696
96* HNF4A_19822575_ChIP-Seq_HepG2_Human1.20871846
97TP63_17297297_ChIP-ChIP_HaCaT_Human1.20857013
98POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20802331
99ERG_21242973_ChIP-ChIP_JURKAT_Human1.20385892
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.19703591
101RACK7_27058665_Chip-Seq_MCF-7_Human1.19564687
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.19268825
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.18471609
104FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18471609
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17469934
106IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17282050
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17221425
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15932519
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15845222
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15135712
111OCT4_20526341_ChIP-Seq_ESCs_Human1.14865206
112EGR1_19032775_ChIP-ChIP_M12_Human1.13002111
113SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12934368
114GATA3_21878914_ChIP-Seq_MCF-7_Human1.12549914
115HTT_18923047_ChIP-ChIP_STHdh_Human1.12065422
116THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11054994
117IGF1R_20145208_ChIP-Seq_DFB_Human1.10711105
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08706186
119TTF2_22483619_ChIP-Seq_HELA_Human1.08222640
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07649130
121AR_20517297_ChIP-Seq_VCAP_Human1.07244402
122BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06404082
123RAC3_21632823_ChIP-Seq_H3396_Human1.05710834
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04863540
125MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04766474
126GATA6_25053715_ChIP-Seq_YYC3_Human1.04723593
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04723139
128ERA_21632823_ChIP-Seq_H3396_Human1.04531005
129ERG_20517297_ChIP-Seq_VCAP_Human1.03093115
130NCOR_22424771_ChIP-Seq_293T_Human1.02410739
131MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02241142
132CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02197414
133SOX2_20726797_ChIP-Seq_SW620_Human1.01933534
134AHR_22903824_ChIP-Seq_MCF-7_Human1.01635168
135VDR_24787735_ChIP-Seq_THP-1_Human1.01562151
136NANOG_19829295_ChIP-Seq_ESCs_Human1.01265267
137SOX2_19829295_ChIP-Seq_ESCs_Human1.01265267
138SMAD4_21741376_ChIP-Seq_HESCs_Human1.00942533
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99606892
140PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98949019
141ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98207449
142MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96417066
143ARNT_22903824_ChIP-Seq_MCF-7_Human0.96180283
144PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96078717
145ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95998182
146GATA1_19941826_ChIP-Seq_K562_Human0.95611853
147SOX2_16153702_ChIP-ChIP_HESCs_Human0.95547960
148TAF2_19829295_ChIP-Seq_ESCs_Human0.95342393
149PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93667997
150ZNF263_19887448_ChIP-Seq_K562_Human0.93391449
151RNF2_27304074_Chip-Seq_NSC_Mouse0.92975337
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92434280
153GATA2_19941826_ChIP-Seq_K562_Human0.92332739
154E2F7_22180533_ChIP-Seq_HELA_Human0.91855647
155TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91793601
156KDM5A_27292631_Chip-Seq_BREAST_Human0.91678519
157GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91499817
158* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90940885
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90767827
160SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90738534
161KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90003200
162GATA1_22025678_ChIP-Seq_K562_Human0.89994371
163FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.89731274
164TCF4_23295773_ChIP-Seq_U87_Human0.89548494
165AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89541915
166SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88372029
167CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88226301
168GABP_19822575_ChIP-Seq_HepG2_Human0.88222522
169XRN2_22483619_ChIP-Seq_HELA_Human0.88119911
170FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87248636
171CDX2_22108803_ChIP-Seq_LS180_Human0.86926348
172SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86069835
173EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84540723
174AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84181236
175BP1_19119308_ChIP-ChIP_Hs578T_Human0.83363976
176ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82630417
177HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82474454
178P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82293591
179TP63_23658742_ChIP-Seq_EP156T_Human0.80515304
180NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79879980
181STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79045171
182TCF4_18268006_ChIP-ChIP_LS174T_Human0.77973556
183KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76360805
184CREB1_26743006_Chip-Seq_LNCaP_Human0.76244613
185CJUN_26792858_Chip-Seq_BT549_Human0.75434051
186CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.74892286
187RNF2_18974828_ChIP-Seq_MESCs_Mouse0.74565198
188EZH2_18974828_ChIP-Seq_MESCs_Mouse0.74565198
189GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74280414
190* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.73193192
191SOX9_24532713_ChIP-Seq_HFSC_Mouse0.72466256
192ELK3_25401928_ChIP-Seq_HUVEC_Human0.72355099

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation7.60522719
2MP0005360_urolithiasis6.61537262
3MP0004019_abnormal_vitamin_homeostasis4.66987793
4MP0005332_abnormal_amino_acid4.65802824
5MP0003195_calcinosis4.33374982
6* MP0001765_abnormal_ion_homeostasis4.02461021
7* MP0009643_abnormal_urine_homeostasis4.02369298
8MP0002138_abnormal_hepatobiliary_system3.77835006
9MP0002139_abnormal_hepatobiliary_system3.65507879
10MP0002254_reproductive_system_inflammat3.58241366
11MP0001756_abnormal_urination3.48287183
12MP0005083_abnormal_biliary_tract3.25037662
13* MP0002136_abnormal_kidney_physiology3.21625391
14* MP0005636_abnormal_mineral_homeostasis3.00868162
15MP0008961_abnormal_basal_metabolism2.95998405
16MP0001958_emphysema2.77821624
17MP0003252_abnormal_bile_duct2.64676401
18MP0005377_hearing/vestibular/ear_phenot2.56209351
19MP0003878_abnormal_ear_physiology2.56209351
20MP0001348_abnormal_lacrimal_gland2.33900814
21MP0008875_abnormal_xenobiotic_pharmacok2.28152798
22MP0004885_abnormal_endolymph2.09313293
23MP0005365_abnormal_bile_salt2.03203315
24MP0000427_abnormal_hair_cycle1.90213625
25MP0000383_abnormal_hair_follicle1.81492471
26MP0003300_gastrointestinal_ulcer1.81029765
27MP0001346_abnormal_lacrimal_gland1.76465718
28MP0003567_abnormal_fetal_cardiomyocyte1.70540050
29MP0005551_abnormal_eye_electrophysiolog1.68092286
30MP0005058_abnormal_lysosome_morphology1.63798112
31MP0005646_abnormal_pituitary_gland1.63698354
32MP0005085_abnormal_gallbladder_physiolo1.61840699
33MP0000647_abnormal_sebaceous_gland1.57802319
34MP0001968_abnormal_touch/_nociception1.56510972
35MP0003186_abnormal_redox_activity1.49988775
36MP0002168_other_aberrant_phenotype1.46826333
37* MP0000230_abnormal_systemic_arterial1.42570184
38MP0008058_abnormal_DNA_repair1.42436476
39MP0005584_abnormal_enzyme/coenzyme_acti1.42405320
40MP0002928_abnormal_bile_duct1.39522558
41MP0008877_abnormal_DNA_methylation1.39510126
42* MP0008872_abnormal_physiological_respon1.36740036
43MP0003136_yellow_coat_color1.35071473
44MP0001986_abnormal_taste_sensitivity1.33411408
45* MP0002135_abnormal_kidney_morphology1.32601522
46MP0003786_premature_aging1.30489810
47MP0010678_abnormal_skin_adnexa1.30361787
48MP0005451_abnormal_body_composition1.28986523
49MP0003718_maternal_effect1.27465636
50MP0001873_stomach_inflammation1.26223413
51MP0000538_abnormal_urinary_bladder1.24927137
52MP0010094_abnormal_chromosome_stability1.23160933
53MP0005253_abnormal_eye_physiology1.22752219
54MP0005319_abnormal_enzyme/_coenzyme1.20238894
55MP0004133_heterotaxia1.19506063
56MP0002736_abnormal_nociception_after1.19046623
57MP0001879_abnormal_lymphatic_vessel1.17698434
58MP0003693_abnormal_embryo_hatching1.17343929
59MP0004272_abnormal_basement_membrane1.16005524
60MP0006035_abnormal_mitochondrial_morpho1.13833798
61MP0003283_abnormal_digestive_organ1.11204536
62MP0006072_abnormal_retinal_apoptosis1.09865088
63MP0002896_abnormal_bone_mineralization1.08782995
64MP0005084_abnormal_gallbladder_morpholo1.06846127
65MP0005666_abnormal_adipose_tissue1.05963091
66MP0003890_abnormal_embryonic-extraembry1.04536085
67MP0002909_abnormal_adrenal_gland1.02988854
68MP0005535_abnormal_body_temperature1.01162503
69MP0010386_abnormal_urinary_bladder1.00737454
70MP0006036_abnormal_mitochondrial_physio1.00550548
71MP0010368_abnormal_lymphatic_system0.97925547
72MP0005670_abnormal_white_adipose0.95964168
73MP0002009_preneoplasia0.95605619
74MP0005174_abnormal_tail_pigmentation0.94283391
75MP0002638_abnormal_pupillary_reflex0.88837271
76MP0000631_abnormal_neuroendocrine_gland0.88490919
77MP0000372_irregular_coat_pigmentation0.88420375
78MP0002098_abnormal_vibrissa_morphology0.86652669
79MP0005645_abnormal_hypothalamus_physiol0.86013966
80MP0002160_abnormal_reproductive_system0.85797499
81MP0005647_abnormal_sex_gland0.85540746
82MP0005410_abnormal_fertilization0.84074838
83MP0004215_abnormal_myocardial_fiber0.82602073
84MP0002837_dystrophic_cardiac_calcinosis0.81811119
85MP0004084_abnormal_cardiac_muscle0.80751401
86MP0002938_white_spotting0.80540604
87MP0003806_abnormal_nucleotide_metabolis0.79447540
88MP0005167_abnormal_blood-brain_barrier0.78966968
89MP0005165_increased_susceptibility_to0.78030643
90MP0000537_abnormal_urethra_morphology0.77147721
91MP0000747_muscle_weakness0.76966645
92MP0010234_abnormal_vibrissa_follicle0.76554880
93MP0003638_abnormal_response/metabolism_0.76141809
94MP0002876_abnormal_thyroid_physiology0.75740588
95MP0002118_abnormal_lipid_homeostasis0.75650850
96MP0004957_abnormal_blastocyst_morpholog0.75367142
97MP0005423_abnormal_somatic_nervous0.73405053
98MP0002089_abnormal_postnatal_growth/wei0.73249823
99MP0000678_abnormal_parathyroid_gland0.73012312
100MP0002210_abnormal_sex_determination0.72457650
101* MP0009642_abnormal_blood_homeostasis0.69945762
102MP0004147_increased_porphyrin_level0.69450548
103MP0001661_extended_life_span0.69105157
104MP0001929_abnormal_gametogenesis0.68966722
105MP0002102_abnormal_ear_morphology0.68848825
106MP0005220_abnormal_exocrine_pancreas0.68508779
107MP0003950_abnormal_plasma_membrane0.67508567
108MP0009764_decreased_sensitivity_to0.67082184
109MP0001293_anophthalmia0.66550621
110MP0000534_abnormal_ureter_morphology0.66273587
111MP0001944_abnormal_pancreas_morphology0.65812475
112MP0003698_abnormal_male_reproductive0.65307185
113MP0004264_abnormal_extraembryonic_tissu0.65040850
114MP0003943_abnormal_hepatobiliary_system0.65026589
115MP0001905_abnormal_dopamine_level0.64327131
116MP0004484_altered_response_of0.64196343
117MP0003959_abnormal_lean_body0.63980983
118MP0005389_reproductive_system_phenotype0.63726959
119MP0002998_abnormal_bone_remodeling0.62200254
120MP0005395_other_phenotype0.62175948
121MP0000470_abnormal_stomach_morphology0.61957856
122MP0008995_early_reproductive_senescence0.61928799
123MP0002163_abnormal_gland_morphology0.61845703
124MP0004142_abnormal_muscle_tone0.61110654
125MP0001764_abnormal_homeostasis0.59244698
126MP0003566_abnormal_cell_adhesion0.59181857
127MP0003172_abnormal_lysosome_physiology0.57637583
128MP0001145_abnormal_male_reproductive0.57548686
129MP0000358_abnormal_cell_content/0.57532916
130MP0005391_vision/eye_phenotype0.57285251
131MP0008775_abnormal_heart_ventricle0.57151349
132MP0003191_abnormal_cellular_cholesterol0.56783976
133MP0002693_abnormal_pancreas_physiology0.56585656
134MP0002295_abnormal_pulmonary_circulatio0.55872500
135MP0004036_abnormal_muscle_relaxation0.54832624
136MP0001666_abnormal_nutrient_absorption0.53847568
137MP0004858_abnormal_nervous_system0.53585822
138MP0002115_abnormal_skeleton_extremities0.53018256
139MP0005375_adipose_tissue_phenotype0.52974691
140MP0003795_abnormal_bone_structure0.50005899
141MP0010329_abnormal_lipoprotein_level0.49147567
142MP0008469_abnormal_protein_level0.48965396
143MP0001485_abnormal_pinna_reflex0.48953759
144MP0002796_impaired_skin_barrier0.48823987
145MP0003075_altered_response_to0.48699035
146MP0000609_abnormal_liver_physiology0.48569318
147MP0003329_amyloid_beta_deposits0.47026314
148MP0002972_abnormal_cardiac_muscle0.45375464
149MP0003646_muscle_fatigue0.45193497
150MP0000598_abnormal_liver_morphology0.45179761
151MP0005166_decreased_susceptibility_to0.44305541
152MP0005595_abnormal_vascular_smooth0.43885003
153MP0005501_abnormal_skin_physiology0.43394532
154MP0005620_abnormal_muscle_contractility0.43091185
155MP0000163_abnormal_cartilage_morphology0.39786380
156MP0003953_abnormal_hormone_level0.38878780
157MP0002069_abnormal_eating/drinking_beha0.38714120
158MP0001663_abnormal_digestive_system0.38532206
159MP0001270_distended_abdomen0.38146189
160MP0004742_abnormal_vestibular_system0.37974768
161MP0003879_abnormal_hair_cell0.35854973
162MP0003705_abnormal_hypodermis_morpholog0.35582011

Predicted human phenotypes

RankGene SetZ-score
1* Increased circulating renin level (HP:0000848)8.91854430
2Metabolic alkalosis (HP:0200114)8.55438079
3Hyperactive renin-angiotensin system (HP:0000841)8.46005394
4* Hypokalemic alkalosis (HP:0001949)8.10681199
5Abnormality of chloride homeostasis (HP:0011422)7.80511050
6* Hypomagnesemia (HP:0002917)7.22721669
7Gout (HP:0001997)6.87519233
8* Polyuria (HP:0000103)6.76064270
9* Abnormal urine output (HP:0012590)6.26652184
10* Abnormality of magnesium homeostasis (HP:0004921)6.01428893
11* Abnormality of renal excretion (HP:0011036)5.93717656
12Renal salt wasting (HP:0000127)5.72705568
13Hyperaldosteronism (HP:0000859)5.69939969
14* Abnormality of renin-angiotensin system (HP:0000847)5.20754698
15* Alkalosis (HP:0001948)4.94437530
16* Polydipsia (HP:0001959)4.88551660
17* Abnormal drinking behavior (HP:0030082)4.88551660
18Proximal tubulopathy (HP:0000114)4.73904034
19Increased purine levels (HP:0004368)4.68905813
20Hyperuricemia (HP:0002149)4.68905813
21* Tetany (HP:0001281)4.44528398
22Hypercalciuria (HP:0002150)4.14073125
23Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11468965
24Abnormality of purine metabolism (HP:0004352)4.06000266
25Hyperglycinuria (HP:0003108)3.93732236
26* Hypokalemia (HP:0002900)3.92276033
27* Abnormality of potassium homeostasis (HP:0011042)3.56793559
28Generalized aminoaciduria (HP:0002909)3.56299802
29Cerebellar dysplasia (HP:0007033)3.54394120
30Amelogenesis imperfecta (HP:0000705)3.42401281
31Renal tubular acidosis (HP:0001947)3.40452287
32Abnormality of glycine metabolism (HP:0010895)3.22804134
33Abnormality of serine family amino acid metabolism (HP:0010894)3.22804134
34Ketoacidosis (HP:0001993)3.10525635
35Nephrocalcinosis (HP:0000121)3.07811454
36Glycosuria (HP:0003076)3.07527989
37Abnormality of urine glucose concentration (HP:0011016)3.07527989
38Delayed epiphyseal ossification (HP:0002663)3.03375479
39Tubular atrophy (HP:0000092)2.92666751
40Abnormality of nucleobase metabolism (HP:0010932)2.91691333
41Abnormality of proline metabolism (HP:0010907)2.89426613
42Hydroxyprolinuria (HP:0003080)2.89426613
43Hyperphosphaturia (HP:0003109)2.87486194
44Hyponatremia (HP:0002902)2.85342764
45Metaphyseal cupping (HP:0003021)2.78615104
46Abnormality of sodium homeostasis (HP:0010931)2.78391358
47Vascular calcification (HP:0004934)2.75889135
48Abnormal urine phosphate concentration (HP:0012599)2.75253700
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.72774610
50Abnormality of alanine metabolism (HP:0010916)2.72774610
51Hyperalaninemia (HP:0003348)2.72774610
52Adrenal overactivity (HP:0002717)2.68846811
53Ketosis (HP:0001946)2.65681226
54Glomerulosclerosis (HP:0000096)2.64448336
55Nephrolithiasis (HP:0000787)2.57388556
56Hypophosphatemia (HP:0002148)2.56440508
57Dehydration (HP:0001944)2.54741393
58Abnormality of fatty-acid metabolism (HP:0004359)2.54054991
59Abnormality of the renal cortex (HP:0011035)2.52078492
60Pancreatic cysts (HP:0001737)2.51031540
61Abnormality of dental color (HP:0011073)2.50541719
62Fair hair (HP:0002286)2.48903394
63Abnormality of renal resorption (HP:0011038)2.47925400
64Cardiovascular calcification (HP:0011915)2.46874874
65Partial agenesis of the corpus callosum (HP:0001338)2.41096890
66Focal segmental glomerulosclerosis (HP:0000097)2.37930559
67Rickets (HP:0002748)2.35249094
68Facial shape deformation (HP:0011334)2.33994525
69Potter facies (HP:0002009)2.33994525
70Hyperkalemia (HP:0002153)2.33807393
71Tubulointerstitial fibrosis (HP:0005576)2.31705608
72Abnormality of the renal medulla (HP:0100957)2.31084401
73Lymphangioma (HP:0100764)2.29823071
74Congenital stationary night blindness (HP:0007642)2.25954320
75Widely patent fontanelles and sutures (HP:0004492)2.24359655
76Hyperglycinemia (HP:0002154)2.24155580
77Aplasia/Hypoplasia of the spleen (HP:0010451)2.20648730
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20578104
79Asplenia (HP:0001746)2.13844819
80Enlarged kidneys (HP:0000105)2.09964318
81Renal cortical cysts (HP:0000803)2.07735870
82Hypotension (HP:0002615)2.07315741
83Thin bony cortex (HP:0002753)2.06224615
84Bilateral sensorineural hearing impairment (HP:0008619)2.03628115
85Attenuation of retinal blood vessels (HP:0007843)2.02649865
86Metaphyseal dysplasia (HP:0100255)2.02109687
87Hyperammonemia (HP:0001987)2.01864061
88Abnormal tarsal ossification (HP:0008369)2.00898325
89Abnormal enzyme/coenzyme activity (HP:0012379)2.00533599
90Delayed CNS myelination (HP:0002188)1.99217175
91Renal tubular dysfunction (HP:0000124)1.98664738
92Abnormality of midbrain morphology (HP:0002418)1.97619806
93Molar tooth sign on MRI (HP:0002419)1.97619806
94Retinal atrophy (HP:0001105)1.97336202
95Vomiting (HP:0002013)1.97097018
96Abnormality of alkaline phosphatase activity (HP:0004379)1.95428730
97* Chondrocalcinosis (HP:0000934)1.92277065
98Vacuolated lymphocytes (HP:0001922)1.92131601
99Type II lissencephaly (HP:0007260)1.88865295
100Metabolic acidosis (HP:0001942)1.84434868
101Decreased circulating renin level (HP:0003351)1.81848828
102Hypoalbuminemia (HP:0003073)1.81252977
103Abnormal albumin level (HP:0012116)1.81252977
104* Abnormality of Sharpey fibers (HP:0100685)1.78424238
105Abnormality of the costochondral junction (HP:0000919)1.78336794
106Confusion (HP:0001289)1.77691234
107Increased CSF lactate (HP:0002490)1.77094960
108Dicarboxylic aciduria (HP:0003215)1.76199219
109Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76199219
110Bicornuate uterus (HP:0000813)1.75591299
111Visceral angiomatosis (HP:0100761)1.74636451
112Malnutrition (HP:0004395)1.73286258
113Lipid accumulation in hepatocytes (HP:0006561)1.71342112
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70840949
115Generalized hypopigmentation of hair (HP:0011358)1.69957789
116Increased hepatocellular lipid droplets (HP:0006565)1.69474691
117Abnormality of aromatic amino acid family metabolism (HP:0004338)1.68246428
118Abolished electroretinogram (ERG) (HP:0000550)1.67641740
119Chorioretinal atrophy (HP:0000533)1.67219856
120Pancreatic fibrosis (HP:0100732)1.64324740
121* Generalized muscle weakness (HP:0003324)1.61845049
122Abnormality of sulfur amino acid metabolism (HP:0004339)1.61670646
123Axonal loss (HP:0003447)1.60456311
124Abnormality of calcium-phosphate metabolism (HP:0100530)1.60010701
125Hemangiomatosis (HP:0007461)1.59923072
126Elevated alkaline phosphatase (HP:0003155)1.59655211
127Abnormality of the nasal septum (HP:0000419)1.58790725
128Cerebral edema (HP:0002181)1.57068087
129Progressive inability to walk (HP:0002505)1.56729293
130Increased serum lactate (HP:0002151)1.54827507
131Lethargy (HP:0001254)1.54621467
132Pendular nystagmus (HP:0012043)1.53285559
133Cystic liver disease (HP:0006706)1.51926792
134Methylmalonic aciduria (HP:0012120)1.51706674
135Bony spicule pigmentary retinopathy (HP:0007737)1.51173698
136Cavernous hemangioma (HP:0001048)1.50368837
137Oligodactyly (hands) (HP:0001180)1.48110215
138Nephronophthisis (HP:0000090)1.45963744
139Aplasia/Hypoplasia involving the musculature (HP:0001460)1.45455376
140Birth length less than 3rd percentile (HP:0003561)1.42557528
141Hypothermia (HP:0002045)1.42466996
142Methylmalonic acidemia (HP:0002912)1.41565652
143Large eyes (HP:0001090)1.41521402
144Inability to walk (HP:0002540)1.40289289
145Hyperventilation (HP:0002883)1.39786774
146Bilateral microphthalmos (HP:0007633)1.38718394
147Abnormality of the phalanges of the 2nd finger (HP:0009541)1.38317508

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* WNK49.84765620
2WNK37.90664687
3* OXSR15.52707278
4WNK13.16747845
5TIE12.77356096
6TGFBR22.40782988
7BCKDK2.22451098
8SGK4942.13314117
9SGK2232.13314117
10TLK12.06803555
11STK38L2.01021763
12PBK2.00690296
13ZAK1.95058164
14PDK31.72029934
15PDK41.72029934
16PDK21.69602880
17NEK11.65630011
18ADRBK21.64570755
19NME11.52777998
20BMPR1B1.51680007
21TNIK1.44145376
22ACVR1B1.43968841
23KDR1.43448521
24SGK21.40924086
25TGFBR11.35124656
26MAP4K21.34276521
27SGK31.33866936
28GRK11.24266071
29DAPK21.20554154
30MAP2K71.18536962
31TXK1.17689489
32MST41.12593632
33LRRK21.10366374
34STK381.09633072
35EPHB11.08324282
36TAOK31.07198909
37AKT31.04861574
38NEK60.98578606
39FGFR40.97423751
40WEE10.95227724
41EPHB20.93693435
42CAMKK20.93559483
43BRSK20.92992376
44MAPKAPK50.91610722
45GSK3A0.91491311
46MYLK0.91151533
47STK30.91131023
48MAP3K40.90936172
49ERN10.90194363
50MAP3K70.88996486
51MAP2K20.88453115
52EIF2AK30.87755569
53PAK40.86958702
54TSSK60.86955676
55PHKG10.84553240
56PHKG20.84553240
57MST1R0.83265424
58SGK10.74979538
59MKNK10.73495327
60PRKG20.68680942
61NUAK10.67580319
62CHEK20.65338799
63MAPKAPK30.64429935
64RIPK10.64317285
65PTK60.61455235
66MAP2K60.61360137
67MAPK130.60762061
68PTK2B0.60634847
69GRK60.58509259
70MKNK20.58300945
71PLK20.57764510
72PTK20.57569396
73DYRK1B0.57556636
74FER0.57029246
75FGFR20.56458440
76MUSK0.56380619
77TRIB30.55693995
78PDPK10.54716786
79MAP3K30.53480153
80NTRK10.53238625
81STK100.52519851
82ATR0.51316526
83PLK10.51279258
84STK160.49678686
85INSRR0.48923523
86NEK20.47855626
87RPS6KB20.47778099
88LATS10.47346759
89ABL20.46850029
90PAK30.46276422
91RPS6KA50.46104158
92PRKD20.46089046
93ADRBK10.45635790
94LATS20.43773580
95PRKAA10.43375488
96NLK0.43037890
97TRIM280.42072204
98PRKCG0.41685155
99MAP2K30.41309556
100EIF2AK10.41124462
101PRKCH0.40451719
102PRKAA20.38651607
103BRD40.38593879
104BUB10.38270644
105PRKCE0.38183490
106PLK40.37876925
107SRPK10.37668792
108IKBKB0.36818058
109PIM10.36622329
110PINK10.36170034
111AURKB0.34473872
112PDK10.32411606
113CSNK1A10.31608291
114FRK0.30479512
115BMPR20.30112301
116MAPK120.29618845
117MAPK110.29132332
118TTK0.28824863
119PDGFRA0.28434159
120STK110.28053976
121ROCK10.27646586
122MET0.27191778
123MAP3K20.25365630
124PRKD10.23393554
125PRKCZ0.23338166
126RPS6KA40.23176834
127ATM0.22834158
128PLK30.22627965
129PRKCQ0.22298408
130AURKA0.22015428
131MAP3K140.21253070
132CASK0.20967083
133MAPK150.20199540
134MAP3K130.19751873
135PRKCI0.19667663
136SCYL20.16677241
137PRKACG0.16484729
138SRC0.15757315
139BMX0.15508142
140PRKCD0.14920834
141AKT20.14523944
142JAK20.13473709
143PRKACA0.11387113
144PRKCA0.10188857
145CAMK1G0.09883039
146MTOR0.09330500
147SIK10.08982862
148IGF1R0.08824816
149MAPK40.08808733
150MAP2K40.08665477
151INSR0.08657962
152PRKD30.08631402
153MAP3K60.08506230
154PKN20.07897376
155PAK20.07411109
156MINK10.07308701
157CSK0.06391159
158MAP2K10.05502666
159CAMK40.05351174
160SIK20.04931111
161EGFR0.04472997
162ROCK20.04028248
163ABL10.03863725
164FYN0.02214152
165NEK90.01577004
166MAP4K10.01534460
167MARK30.01464988

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.89459714
2Butanoate metabolism_Homo sapiens_hsa006503.35038060
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.25245247
4Propanoate metabolism_Homo sapiens_hsa006403.18162495
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.16313276
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.10491048
7Collecting duct acid secretion_Homo sapiens_hsa049663.02772274
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.99167920
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.97320970
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.67216906
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.55334619
12Fatty acid degradation_Homo sapiens_hsa000712.39004106
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.38319560
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.36293470
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35272459
16Pyruvate metabolism_Homo sapiens_hsa006202.29160166
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15333679
18Peroxisome_Homo sapiens_hsa041462.12986553
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11285503
20Basal transcription factors_Homo sapiens_hsa030222.03151610
21Homologous recombination_Homo sapiens_hsa034402.02430827
22Tryptophan metabolism_Homo sapiens_hsa003802.01271859
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.98929146
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95338621
25Vitamin digestion and absorption_Homo sapiens_hsa049771.95099898
26Bile secretion_Homo sapiens_hsa049761.82334635
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75627080
28beta-Alanine metabolism_Homo sapiens_hsa004101.72540844
29Fatty acid metabolism_Homo sapiens_hsa012121.68459898
30One carbon pool by folate_Homo sapiens_hsa006701.66121967
31Fanconi anemia pathway_Homo sapiens_hsa034601.63303345
32Carbon metabolism_Homo sapiens_hsa012001.60826034
33Linoleic acid metabolism_Homo sapiens_hsa005911.59539207
34Mineral absorption_Homo sapiens_hsa049781.57885973
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57353897
36Protein digestion and absorption_Homo sapiens_hsa049741.51551675
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50897660
38Sulfur metabolism_Homo sapiens_hsa009201.44279420
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43572171
40Lysine degradation_Homo sapiens_hsa003101.42210363
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38882741
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38589390
43Glutathione metabolism_Homo sapiens_hsa004801.38502484
44Ether lipid metabolism_Homo sapiens_hsa005651.37124706
45Renin-angiotensin system_Homo sapiens_hsa046141.36019171
46Phototransduction_Homo sapiens_hsa047441.32692379
47RNA degradation_Homo sapiens_hsa030181.30254919
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25358238
49Protein export_Homo sapiens_hsa030601.24644739
50Nitrogen metabolism_Homo sapiens_hsa009101.22672755
51PPAR signaling pathway_Homo sapiens_hsa033201.22416452
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21739495
53Arginine and proline metabolism_Homo sapiens_hsa003301.20993037
54RNA polymerase_Homo sapiens_hsa030201.16359259
55RNA transport_Homo sapiens_hsa030131.16209938
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.15864664
57Other glycan degradation_Homo sapiens_hsa005111.13847140
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12941533
59Arginine biosynthesis_Homo sapiens_hsa002201.07096930
60Hedgehog signaling pathway_Homo sapiens_hsa043401.01470817
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98114651
62Non-homologous end-joining_Homo sapiens_hsa034500.95292043
63Primary immunodeficiency_Homo sapiens_hsa053400.92828755
64Huntingtons disease_Homo sapiens_hsa050160.92824623
65Olfactory transduction_Homo sapiens_hsa047400.92308634
66Purine metabolism_Homo sapiens_hsa002300.92071830
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.91614530
68Starch and sucrose metabolism_Homo sapiens_hsa005000.91178641
69Regulation of autophagy_Homo sapiens_hsa041400.90456522
70Folate biosynthesis_Homo sapiens_hsa007900.90449615
71Gastric acid secretion_Homo sapiens_hsa049710.90165265
72Ribosome_Homo sapiens_hsa030100.89408928
73Phenylalanine metabolism_Homo sapiens_hsa003600.89313048
74Proteasome_Homo sapiens_hsa030500.88973175
75DNA replication_Homo sapiens_hsa030300.87963421
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84450603
77Sulfur relay system_Homo sapiens_hsa041220.83912906
78Biosynthesis of amino acids_Homo sapiens_hsa012300.83500863
79Histidine metabolism_Homo sapiens_hsa003400.83395974
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82933543
81Glycerolipid metabolism_Homo sapiens_hsa005610.82291532
82Thyroid hormone synthesis_Homo sapiens_hsa049180.81330018
83Morphine addiction_Homo sapiens_hsa050320.79001751
84Nucleotide excision repair_Homo sapiens_hsa034200.78245842
85Ovarian steroidogenesis_Homo sapiens_hsa049130.76925385
86Taste transduction_Homo sapiens_hsa047420.76309847
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75979926
88Caffeine metabolism_Homo sapiens_hsa002320.71358873
89Selenocompound metabolism_Homo sapiens_hsa004500.68348103
90Alzheimers disease_Homo sapiens_hsa050100.66992945
91Fatty acid biosynthesis_Homo sapiens_hsa000610.63134523
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59162968
93Fructose and mannose metabolism_Homo sapiens_hsa000510.58900110
94Lysosome_Homo sapiens_hsa041420.58701105
95Nicotine addiction_Homo sapiens_hsa050330.58064724
96Fatty acid elongation_Homo sapiens_hsa000620.55139717
97Pyrimidine metabolism_Homo sapiens_hsa002400.53986013
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53800136
99Pentose phosphate pathway_Homo sapiens_hsa000300.52575608
100Vitamin B6 metabolism_Homo sapiens_hsa007500.51968224
101Vibrio cholerae infection_Homo sapiens_hsa051100.50881925
102Oxidative phosphorylation_Homo sapiens_hsa001900.50388608
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.48308583
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43499123
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.43175438
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42790560
107Mismatch repair_Homo sapiens_hsa034300.42506921
108ABC transporters_Homo sapiens_hsa020100.42399133
109Spliceosome_Homo sapiens_hsa030400.41412928
110Basal cell carcinoma_Homo sapiens_hsa052170.40331465
111Chemical carcinogenesis_Homo sapiens_hsa052040.38486692
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.37690459
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36461731
114ECM-receptor interaction_Homo sapiens_hsa045120.36101451
115Metabolic pathways_Homo sapiens_hsa011000.36087908
116Bladder cancer_Homo sapiens_hsa052190.35878444
117Synaptic vesicle cycle_Homo sapiens_hsa047210.35518485
118Choline metabolism in cancer_Homo sapiens_hsa052310.32513780
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.31748893
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29905198
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23843015
122Focal adhesion_Homo sapiens_hsa045100.22970968
123Insulin resistance_Homo sapiens_hsa049310.22174051
124Rheumatoid arthritis_Homo sapiens_hsa053230.19652200
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.19376919
126Leukocyte transendothelial migration_Homo sapiens_hsa046700.18750546
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.18336006
128Parkinsons disease_Homo sapiens_hsa050120.12421068
129Cardiac muscle contraction_Homo sapiens_hsa042600.11700017
130Steroid biosynthesis_Homo sapiens_hsa001000.11400086
131Inositol phosphate metabolism_Homo sapiens_hsa005620.10618777
132Retinol metabolism_Homo sapiens_hsa008300.10552413
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08322868
134Tyrosine metabolism_Homo sapiens_hsa003500.07256081
135Sphingolipid metabolism_Homo sapiens_hsa006000.07099149
136Rap1 signaling pathway_Homo sapiens_hsa040150.05850653
137Arachidonic acid metabolism_Homo sapiens_hsa005900.05225834
138Pancreatic secretion_Homo sapiens_hsa049720.04733850
139Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04544664
140AMPK signaling pathway_Homo sapiens_hsa041520.03450432
141Glucagon signaling pathway_Homo sapiens_hsa049220.03056440
142Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02895430
143Small cell lung cancer_Homo sapiens_hsa052220.02400669
144FoxO signaling pathway_Homo sapiens_hsa040680.01948618
145Tight junction_Homo sapiens_hsa045300.01666209
146Hepatitis C_Homo sapiens_hsa051600.01661719

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